Disease biomarkers

Section edited by Xiangdong Wang

This section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

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  1. Research

    Placental mitochondrial DNA and CYP1A1 gene methylation as molecular signatures for tobacco smoke exposure in pregnant women and the relevance for birth weight

    Maternal smoking during pregnancy results in an increased risk of low birth weight through perturbations in the utero-placental exchange. Epigenetics and mitochondrial function in fetal tissues might be molecular...

    Bram G. Janssen, Wilfried Gyselaers, Hyang-Min Byun, Harry A. Roels, Ann Cuypers, Andrea A. Baccarelli and Tim S. Nawrot

    Journal of Translational Medicine 2017 15:5

    Published on: 4 January 2017

  2. Commentary

    Association of mitochondrial DNA variants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptoms

    Earlier this year, we described an analysis of mitochondrial DNA (mtDNA) variants in myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) patients and healthy controls. We reported that there was no s...

    Maureen R. Hanson, Zhenglong Gu, Alon Keinan, Kaixiong Ye, Arnaud Germain and Paul Billing-Ross

    Journal of Translational Medicine 2016 14:342

    Published on: 20 December 2016

  3. Research

    Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration

    Study of age related macular degeneration (AMD) has been hampered by lack of human models that represent the complexity of the disease. Here we have developed a human in vitro disease model of AMD to investiga...

    Nady Golestaneh, Yi Chu, Shuk Kei Cheng, Hong Cao, Eugenia Poliakov and Daniel M. Berinstein

    Journal of Translational Medicine 2016 14:344

    Published on: 20 December 2016

  4. Research

    Immunological profiling of patients with ulcerative colitis leads to identification of two inflammatory conditions and CD1a as a disease marker

    Conventional approaches to understand mechanisms underlying the development of pathological manifestations in ulcerative colitis (UC) mostly rely on identification of certain cell types and cytokines followed ...

    M. Föhlinger, P. Palamides, U. Mansmann, F. Beigel, M. Siebeck and R. Gropp

    Journal of Translational Medicine 2016 14:310

    Published on: 3 November 2016

  5. Research

    Integrins β1 and β3 are biomarkers of uterine condition for embryo transfer

    Clinical ovulation induction induces blood estrogen (E2) in excess of physiological levels, which can hinder uterine receptivity. In contrast, progesterone produces the opposite clinical effect, suggesting that i...

    Guowu Chen, Aijie Xin, Yulin Liu, Changgen Shi, Junling Chen, Xiaofeng Tang, Ying Chen, Min Yu, Xiandong Peng, Lu Li and Xiaoxi Sun

    Journal of Translational Medicine 2016 14:303

    Published on: 26 October 2016

  6. Meeting report

    Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway

    The goal of biomarker research is to identify clinically valid markers. Despite decades of research there has been disappointingly few molecules or techniques that are in use today. The “1st International NTNU...

    Ana I. Robles, Karina Standahl Olsen, Dana W.T. Tsui, Vassilis Georgoulias, Jenette Creaney, Katalin Dobra, Mogens Vyberg, Nagahiro Minato, Robert A. Anders, Anne-Lise Børresen-Dale, Jianwei Zhou, Pål Sætrom, Boye Schnack Nielsen, Michaela B. Kirschner, Hans E. Krokan, Vassiliki Papadimitrakopoulou…

    Journal of Translational Medicine 2016 14:295

    Published on: 19 October 2016

  7. Research

    A multiplex urinary immunoassay for bladder cancer detection: analysis of a Japanese cohort

    Bladder cancer (BCa) is among the most commonly diagnosed malignancies worldwide, and due the high rate of post-operative disease recurrence, it is one of the most prevalent in many countries. The development ...

    Steve Goodison, Osamu Ogawa, Yoshiyuki Matsui, Takashi Kobayashi, Makito Miyake, Sayuri Ohnishi, Kiyohide Fujimoto, Yunfeng Dai, Yoshiko Shimizu, Kazue Tsukikawa, Hideki Furuya and Charles J. Rosser

    Journal of Translational Medicine 2016 14:287

    Published on: 7 October 2016

  8. Research

    Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla

    Mutations in the isocitrate dehydrogenase enzyme are present in a majority of lower-grade gliomas and secondary glioblastomas. This mis-sense mutation results in the neomorphic reduction of isocitrate dehydrog...

    Gaurav Verma, Suyash Mohan, MacLean P. Nasrallah, Steven Brem, John Y. K. Lee, Sanjeev Chawla, Sumei Wang, Rajakumar Nagarajan, M. Albert Thomas and Harish Poptani

    Journal of Translational Medicine 2016 14:274

    Published on: 22 September 2016

  9. Research

    Immunogenic FEAT protein circulates in the bloodstream of cancer patients

    FEAT is an intracellular protein that potently drives tumorigenesis in vivo. It is only weakly expressed in normal human tissues, including the testis. In contrast, FEAT is aberrantly upregulated in most human...

    Yan Li, Kyosuke Kobayashi, Marwa M. Mona, Chikako Satomi, Shinji Okano, Hiroyuki Inoue, Kenzaburo Tani and Atsushi Takahashi

    Journal of Translational Medicine 2016 14:275

    Published on: 22 September 2016

  10. Review

    Decoding the usefulness of non-coding RNAs as breast cancer markers

    Although important advances in the management of breast cancer (BC) have been recently accomplished, it still constitutes the leading cause of cancer death in women worldwide. BC is a heterogeneous and complex...

    Maria Amorim, Sofia Salta, Rui Henrique and Carmen Jerónimo

    Journal of Translational Medicine 2016 14:265

    Published on: 15 September 2016

  11. Research

    Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease

    We recently demonstrated a positive effect of berberine on nonalcoholic fatty liver disease patients after 16 weeks of treatment by comparing mere lifestyle intervention in type 2 diabetes patients with berber...

    Xinxia Chang, Zhe Wang, Jinlan Zhang, Hongmei Yan, Hua Bian, Mingfeng Xia, Huandong Lin, Jiandong Jiang and Xin Gao

    Journal of Translational Medicine 2016 14:266

    Published on: 15 September 2016

  12. Research

    Salivary psoriasin (S100A7) correlates with diffusion capacity of carbon monoxide in a large cohort of systemic sclerosis patients

    Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and the internal organs. In a previous work we suggested a correlation between levels of salivary psoriasin (...

    Laura Giusti, Francesca Sernissi, Elena Donadio, Federica Ciregia, Camillo Giacomelli, Gino Giannaccini, Maria Rosa Mazzoni, Antonio Lucacchini and Laura Bazzichi

    Journal of Translational Medicine 2016 14:262

    Published on: 8 September 2016

  13. Research

    Biomarkers of inflammation and innate immunity in atrophic nonunion fracture

    Nonunion is a failure of healing following a bone fracture. Its physiopathology remains partially unclear and the discovery of new mediators could promote the understanding of bone healing.

    Dominique de Seny, Gaël Cobraiville, Pierre Leprince, Marianne Fillet, Charlotte Collin, Myrielle Mathieu, Jean-Philippe Hauzeur, Valérie Gangji and Michel G. Malaise

    Journal of Translational Medicine 2016 14:258

    Published on: 6 September 2016

  14. Review

    Ockham’s razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer

    Idiopathic pulmonary fibrosis (IPF) identifies a specific lung disorder characterized by chronic, progressive fibrosing interstitial pneumonia of unknown etiology, which lacks effective treatment. According to...

    Giulia M. Stella, Alessandra Gentile, Alice Baderacchi, Federica Meloni, Melissa Milan and Silvia Benvenuti

    Journal of Translational Medicine 2016 14:256

    Published on: 2 September 2016

  15. Research

    Methylation pattern analysis in prostate cancer tissue: identification of biomarkers using an MS-MLPA approach

    Epigenetic silencing mediated by CpG island methylation is a common feature of many cancers. Characterizing aberrant DNA methylation changes associated with prostate carcinogenesis could potentially identify a...

    Giorgia Gurioli, Samanta Salvi, Filippo Martignano, Flavia Foca, Roberta Gunelli, Matteo Costantini, Giacomo Cicchetti, Ugo De Giorgi, Persio Dello Sbarba, Daniele Calistri and Valentina Casadio

    Journal of Translational Medicine 2016 14:249

    Published on: 30 August 2016

  16. Research

    Salivary peptidome profiling for diagnosis of severe early childhood caries

    Severe early childhood caries (s-ECC), which has quite high prevalence among children, is a widespread problem with significant impacts among both developing and developed countries. At present, it is widely k...

    Xiangyu Sun, Xin Huang, Xu Tan, Yan Si, Xiaozhe Wang, Feng Chen and Shuguo Zheng

    Journal of Translational Medicine 2016 14:240

    Published on: 15 August 2016

  17. Research

    Role of KIR and CD16A genotypes in colorectal carcinoma genetic risk and clinical stage

    NK cell cytotoxicity is regulated by the types of the interaction between killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) class I ligands on target cells and the different binding...

    Angelica Canossi, Anna Aureli, Tiziana Del Beato, Piero Rossi, Luana Franceschilli, Flavio De Sanctis, Pierpaolo Sileri, Nicola di Lorenzo, Oreste Buonomo, Davide Lauro, Adriano Venditti and Giuseppe Sconocchia

    Journal of Translational Medicine 2016 14:239

    Published on: 12 August 2016

  18. Research

    Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients

    Hemodialysis patients have higher rates of cardiovascular morbidity and mortality compared to the general population. Mannose-binding lectin (MBL) plays an important role in the development of cardiovascular d...

    Felix Poppelaars, Mariana Gaya da Costa, Stefan P. Berger, Solmaz Assa, Anita H. Meter-Arkema, Mohamed R. Daha, Willem J. van Son, Casper F. M. Franssen and Marc A. J. Seelen

    Journal of Translational Medicine 2016 14:236

    Published on: 5 August 2016

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:245

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