Cardiovascular, metabolic and Lipoprotein translation

Section edited by Nehal N. Mehta

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

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  1. Research

    Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction

    We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk ...

    Ze-Bang Lin, Hong-Bo Ci, Yan Li, Tian-Pu Cheng, Dong-Hong Liu, Yan-Sheng Wang, Jun Xu, Hao-Xiang Yuan, Hua-Ming Li, Jing Chen, Li Zhou, Zhi-Ping Wang, Xi Zhang, Zhi-Jun Ou and Jing-Song Ou

    Journal of Translational Medicine 2017 15:4

    Published on: 4 January 2017

  2. Research

    Thyroid hormones associate with risk of incident chronic kidney disease and rapid decline in renal function: a prospective investigation

    Thyroid hormones have been associated with renal dysfunction in cross-sectional studies. However, prospective studies exploring the effect of thyroid hormones on renal function decline were sparse and got cont...

    Xiaolin Huang, Lin Ding, Kui Peng, Lin Lin, Tiange Wang, Zhiyun Zhao, Yu Xu, Jieli Lu, Yuhong Chen, Weiqing Wang, Yufang Bi, Guang Ning and Min Xu

    Journal of Translational Medicine 2016 14:336

    Published on: 3 December 2016

  3. Research

    CDKN2B methylation is associated with carotid artery calcification in ischemic stroke patients

    Cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) near chromosome 9p21 have been associated with both atherosclerosis and artery calcification, but the underlying mechanisms remained largely unknown. Considerin...

    Shuyu Zhou, Yumeng Zhang, Li Wang, Zhizhong Zhang, Biyang Cai, Keting Liu, Hao Zhang, Minhui Dai, Lingli Sun, Xiaomeng Xu, Huan Cai, Xinfeng Liu, Guangming Lu and Gelin Xu

    Journal of Translational Medicine 2016 14:333

    Published on: 1 December 2016

  4. Research

    The magnitude of nephron number reduction mediates intrauterine growth-restriction-induced long term chronic renal disease in the rat. A comparative study in two experimental models

    Intrauterine growth restriction (IUGR) is a risk factor for hypertension (HT) and chronic renal disease (CRD). A reduction in the nephron number is proposed to be the underlying mechanism; however, the mechani...

    Farid Boubred, Laurent Daniel, Christophe Buffat, Michel Tsimaratos, Charles Oliver, Martine Lelièvre-Pégorier and Umberto Simeoni

    Journal of Translational Medicine 2016 14:331

    Published on: 30 November 2016

  5. Review

    Action mechanism and cardiovascular effect of anthocyanins: a systematic review of animal and human studies

    Cardiovascular diseases (CVD) are an important cause of death worldwide. Anthocyanins are a subgroup of flavonoids found in berries, flowers, fruits and leaves. In epidemiological and clinical studies, these p...

    Jordano Ferreira Reis, Valter Vinicius Silva Monteiro, Rafaelli de Souza Gomes, Matheus Moraes do Carmo, Glauber Vilhena da Costa, Paula Cardoso Ribera and Marta Chagas Monteiro

    Journal of Translational Medicine 2016 14:315

    Published on: 15 November 2016

  6. Research

    Angiopoietin-2 impairs collateral artery growth associated with the suppression of the infiltration of macrophages in mouse hindlimb ischaemia

    Angiopoietin-2 (Ang-2), a ligand of the Tie-2 receptor, plays an important role in maintaining endothelial cells and in destabilizing blood vessels. Collateral artery growth (arteriogenesis) is a key adaptive ...

    Xiaoyong Tan, Kai Yan, Meiping Ren, Ni Chen, Yongjie Li, Xin Deng, Liqun Wang, Rong Li, Mao Luo, Yong Liu, Yan Liu and Jianbo Wu

    Journal of Translational Medicine 2016 14:306

    Published on: 26 October 2016

  7. Research

    Leptin decreases the expression of low-density lipoprotein receptor via PCSK9 pathway: linking dyslipidemia with obesity

    Previous studies have suggested that people with obesity showed elevated serum levels of leptin as well as lipid dysfunction and proprotein convertase subtilisin/kexin type 9 (PCSK9) played an important role i...

    Ying Du, Sha Li, Chuan-Jue Cui, Yan Zhang, Sheng-Hua Yang and Jian-Jun Li

    Journal of Translational Medicine 2016 14:276

    Published on: 23 September 2016

  8. Review

    Repurposing of approved cardiovascular drugs

    Research and development of new drugs requires both long time and high costs, whereas safety and tolerability profiles make the success rate of approval very low. Drug repurposing, applying known drugs and com...

    Junichi Ishida, Masaaki Konishi, Nicole Ebner and Jochen Springer

    Journal of Translational Medicine 2016 14:269

    Published on: 20 September 2016

  9. Research

    Mechanisms underlying the antihypertensive properties of Urtica dioica

    Urtica dioica has traditionally been used in the management of cardiovascular disorders especially hypertension. The aim of this study was to explore pharmacological base of its use in...

    Rahila Qayyum, Hafiz Misbah-ud-Din Qamar, Shamim Khan, Umme Salma, Taous Khan and Abdul Jabbar Shah

    Journal of Translational Medicine 2016 14:254

    Published on: 1 September 2016

  10. Research

    Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study

    Understanding the underlying mechanism of thrombus formation and its components is critical for effective prevention and treatment of ischemic stroke. The generation of thrombotic clots requires conversion of ...

    Slaven Pikija, Vladimir Trkulja, Johannes Sebastian Mutzenbach, Mark R. McCoy, Patricia Ganger and Johann Sellner

    Journal of Translational Medicine 2016 14:250

    Published on: 30 August 2016

  11. Research

    Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease

    Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary ar...

    Inmaculada Moreno-Santos, Luis Miguel Pérez-Belmonte, Manuel Macías-González, María José Mataró, Daniel Castellano, Miguel López-Garrido, Carlos Porras-Martín, Pedro L. Sánchez-Fernández, Juan José Gómez-Doblas, Fernando Cardona, Eduardo de Teresa-Galván and Manuel Jiménez-Navarro

    Journal of Translational Medicine 2016 14:243

    Published on: 19 August 2016

  12. Research

    Could patents interfere with the development of a cardiovascular polypill?

    The Wellcome Trust, the World Health Organization, and cardiologists have advocated for the idea of a “polypill” containing multiple cardiovascular drugs to be co-formulated into a single pill for over a decad...

    Reed F. Beall, Jon-David R. Schwalm, Mark D. Huffman, Tara McCready, Salim Yusuf and Amir Attaran

    Journal of Translational Medicine 2016 14:242

    Published on: 18 August 2016

  13. Research

    Integrative analysis of metabolome and gut microbiota in diet-induced hyperlipidemic rats treated with berberine compounds

    Hyperlipidemia is a major component of metabolic syndrome, and often predicts cardiovascular diseases. We developed a new therapeutic agent berberine compounds (BC), consisting of berberine, oryzanol and vitam...

    Meng Li, Xiangbing Shu, Hanchen Xu, Chunlei Zhang, Lili Yang, Li Zhang and Guang Ji

    Journal of Translational Medicine 2016 14:237

    Published on: 5 August 2016

  14. Research

    Impact of intra-operative cell salvage on blood coagulation in high-bleeding-risk patients undergoing cardiac surgery with cardiopulmonary bypass: a prospective randomized and controlled trial

    Intra-operative cell salvage (CS) was reported to have no impairment on blood coagulation in low-bleeding-risk cardiac surgery with cardiopulmonary bypass (CPB), but studies in high-bleeding-risk cardiac surge...

    Sheliang Shen, Jun Zhang, Wenyuan Wang, Jiayin Zheng and Yihong Xie

    Journal of Translational Medicine 2016 14:228

    Published on: 29 July 2016

  15. Research

    Visualization of atherosclerosis as detected by coronary artery calcium and carotid intima-media thickness reveals significant atherosclerosis in a cross-sectional study of psoriasis patients in a tertiary care center

    Psoriasis is a chronic inflammatory disease of the skin and joints that may also have systemic inflammatory effects, including the development of cardiovascular disease (CVD). Multiple epidemiologic studies ha...

    S. Santilli, D. R. Kast, I. Grozdev, L. Cao, R. L. Feig, J. B. Golden, S. M. Debanne, R. C. Gilkeson, C. E. Orringer, T. S. McCormick, N. L. Ward, K. D. Cooper and N. J. Korman

    Journal of Translational Medicine 2016 14:217

    Published on: 22 July 2016

  16. Research

    Aerobic exercise training protects against endothelial dysfunction by increasing nitric oxide and hydrogen peroxide production in LDL receptor-deficient mice

    Endothelial dysfunction associated with hypercholesterolemia is an early event in atherosclerosis characterized by redox imbalance associated with high superoxide production and reduced nitric oxide (NO) and h...

    Daniele M. Guizoni, Gabriel G. Dorighello, Helena C. F. Oliveira, Maria A. Delbin, Marta H. Krieger and Ana P. Davel

    Journal of Translational Medicine 2016 14:213

    Published on: 19 July 2016

  17. Research

    Characterisation and comparison of adipose tissue macrophages from human subcutaneous, visceral and perivascular adipose tissue

    Macrophages play important roles in adipose tissue inflammation and its consequences. Unfortunately, a detailed description of the macrophage phenotypes in different human adipose tissues is not available.

    Ivana Kralova Lesna, Anna Kralova, Sona Cejkova, Jiri Fronek, Marek Petras, Alena Sekerkova, Filip Thieme, Libor Janousek and Rudolf Poledne

    Journal of Translational Medicine 2016 14:208

    Published on: 11 July 2016

  18. Research

    Long noncoding RNA dysregulation in ischemic heart failure

    Long noncoding RNAs (lncRNAs) are non-protein coding transcripts regulating a variety of physiological and pathological functions. However, their implication in heart failure is still largely unknown. The aim ...

    Simona Greco, Germana Zaccagnini, Alessandra Perfetti, Paola Fuschi, Rea Valaperta, Christine Voellenkle, Serenella Castelvecchio, Carlo Gaetano, Nicoletta Finato, Antonio Paolo Beltrami, Lorenzo Menicanti and Fabio Martelli

    Journal of Translational Medicine 2016 14:183

    Published on: 18 June 2016

  19. Research

    Deciphering the gene expression profile of peroxisome proliferator-activated receptor signaling pathway in the left atria of patients with mitral regurgitation

    Differentially expressed genes in the left atria of mitral regurgitation (MR) pigs have been linked to peroxisome proliferator-activated receptor (PPAR) signaling pathway in the KEGG pathway. However, specific...

    Mien-Cheng Chen, Jen-Ping Chang, Yu-Sheng Lin, Kuo-Li Pan, Wan-Chun Ho, Wen-Hao Liu, Tzu-Hao Chang, Yao-Kuang Huang, Chih-Yuan Fang and Chien-Jen Chen

    Journal of Translational Medicine 2016 14:157

    Published on: 2 June 2016

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