Immunobiology and immunotherapy

Section edited by Adrian Bot

This section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Edited by Pedro Romero.

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  1. Research

    Inhibitory effect of a novel peptide, H-RN, on keratitis induced by LPS or poly(I:C) in vitro and in vivo via suppressing NF-κB and MAPK activation

    Keratitis is a common cause of blindness. Current anti-inflammatory drugs used in keratitis have profound side effects. Small peptides derived from endogenous proteins potentially display both desired efficien...

    Shaopin Zhu, Xun Xu, Lili Wang, Li Su, Qing Gu, Fang Wei and Kun Liu

    Journal of Translational Medicine 2017 15:20

    Published on: 26 January 2017

  2. Research

    Study of the microRNA expression profile of foreskin derived mesenchymal stromal cells following inflammation priming

    Due to their self-renewal capacity, multi-lineage potential, and immunomodulatory properties, mesenchymal stromal cells (MSCs) are an attractive tool for different therapeutic strategies. Foreskin (FSK), consi...

    Hussein Fayyad-Kazan, Mohammad Fayyad-Kazan, Bassam Badran, Dominique Bron, Laurence Lagneaux and Mehdi Najar

    Journal of Translational Medicine 2017 15:10

    Published on: 13 January 2017

  3. Research

    Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response

    Prophylactic and therapeutic vaccines often depend upon a strong activation of the innate immune system to drive a potent adaptive immune response, often mediated by a strong adjuvant. For a number of adjuvant...

    Darin K. Edwards, Edith Jasny, Heesik Yoon, Nigel Horscroft, Brian Schanen, Tanya Geter, Mariola Fotin-Mleczek, Benjamin Petsch and Vaughan Wittman

    Journal of Translational Medicine 2017 15:1

    Published on: 3 January 2017

  4. Research

    Colonization of xenograft tumors by oncolytic vaccinia virus (VACV) results in enhanced tumor killing due to the involvement of myeloid cells

    The mechanisms by which vaccinia virus (VACV) interacts with the innate immune components are complex and involve different mechanisms. iNOS-mediated NO production by myeloid cells is one of the central antivi...

    Mehmet Okyay Kilinc, Klaas Ehrig, Maysam Pessian, Boris R. Minev and Aladar A. Szalay

    Journal of Translational Medicine 2016 14:340

    Published on: 20 December 2016

  5. Research

    Effects by periodontitis on pristane-induced arthritis in rats

    An infection-immune association of periodontal disease with rheumatoid arthritis has been suggested. This study aimed to investigate the effect of pre-existing periodontitis on the development and the immune/i...

    Kaja Eriksson, Erik Lönnblom, Gregory Tour, Anna Kats, Piotr Mydel, Pierre Georgsson, Catharina Hultgren, Nastya Kharlamova, Ulrika Norin, Jörgen Jönsson, Anna Lundmark, Annelie Hellvard, Karin Lundberg, Leif Jansson, Rikard Holmdahl and Tülay Yucel-Lindberg

    Journal of Translational Medicine 2016 14:311

    Published on: 3 November 2016

  6. Research

    Pulsed high-dose dexamethasone modulates Th1-/Th2-chemokine imbalance in immune thrombocytopenia

    Chemokines and chemokine receptors play important roles in autoimmune diseases; however, their role in immune thrombocytopenia (ITP) is unclear. High-dose dexamethasone (HD-DXM) may become a first-line therapy...

    Zongtang Liu, Meiying Wang, Shufen Zhou, Ji Ma, Yan Shi, Jun Peng, Ming Hou and Chengshan Guo

    Journal of Translational Medicine 2016 14:301

    Published on: 24 October 2016

  7. Research

    Discovery of immunodominant T-cell epitopes reveals penton protein as a second immunodominant target in human adenovirus infection

    Human adenovirus (HAdV) infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Efficient antiviral T-cell responses are necessary to clear infect...

    Sabine Tischer, René Geyeregger, Julian Kwoczek, Albert Heim, Constanca Figueiredo, Rainer Blasczyk, Britta Maecker-Kolhoff and Britta Eiz-Vesper

    Journal of Translational Medicine 2016 14:286

    Published on: 7 October 2016

  8. Research

    IL-27 attenuates airway inflammation in a mouse asthma model via the STAT1 and GADD45γ/p38 MAPK pathways

    Asthma is prone to Th2-mediated chronic airway inflammation. Interleukin-27 (IL-27) is a member of the IL-12 family that promotes the differentiation of Th1 cells and inhibits Th2 cells. We use human/mouse CD4+ T...

    Xiaoqiong Su, Jue Pan, Fengxi Bai, Honglei Yuan, Nian Dong, Dandan Li, Xiangdong Wang and Zhihong Chen

    Journal of Translational Medicine 2016 14:283

    Published on: 29 September 2016

  9. Research

    Gemcitabine reduces MDSCs, tregs and TGFβ-1 while restoring the teff/treg ratio in patients with pancreatic cancer

    Cancer immunotherapy can be potentiated by conditioning regimens such as cyclophosphamide, which reduces the level of regulatory T cells (tregs). However, myeloid suppressive cells are still remaining. Accordi...

    Emma Eriksson, Jessica Wenthe, Sandra Irenaeus, Angelica Loskog and Gustav Ullenhag

    Journal of Translational Medicine 2016 14:282

    Published on: 29 September 2016

  10. Research

    In-vitro influence of mycophenolate mofetil (MMF) and Ciclosporin A (CsA) on cytokine induced killer (CIK) cell immunotherapy

    Cytokine-induced-killer (CIK) cells are a promising immunotherapeutic approach for impending relapse following hematopoietic stem cell transplantation (HSCT). However, there is a high risk for treatment failur...

    Melanie Bremm, Sabine Huenecke, Olga Zimmermann, Verena Pfirrmann, Andrea Quaiser, Halvard Bonig, Jan Soerensen, Thomas Klingebiel, Eva Rettinger, Peter Bader and Claudia Cappel

    Journal of Translational Medicine 2016 14:264

    Published on: 13 September 2016

  11. Research

    Spontaneous onset and transplant models of the Vk*MYC mouse show immunological sequelae comparable to human multiple myeloma

    The Vk*MYC transgenic and transplant mouse models of multiple myeloma (MM) are well established as a research tool for anti-myeloma drug discovery. However, little is known of the immune response in these mode...

    Rachel E. Cooke, Nicholas A. Gherardin, Simon J. Harrison, Hang Quach, Dale I. Godfrey, Miles Prince, Rachel Koldej and David S. Ritchie

    Journal of Translational Medicine 2016 14:259

    Published on: 6 September 2016

  12. Research

    Oncolytic virus efficiency inhibited growth of tumour cells with multiple drug resistant phenotype in vivo and in vitro

    Tumour resistance to a wide range of drugs (multiple drug resistant, MDR) acquired after intensive chemotherapy is considered to be the main obstacle of the curative treatment of cancer patients. Recent work h...

    Elena P. Goncharova, Julia S. Ruzhenkova, Ivan S. Petrov, Sergey N. Shchelkunov and Marina A. Zenkova

    Journal of Translational Medicine 2016 14:241

    Published on: 18 August 2016

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:280

  13. Review

    Microbiota and chronic inflammatory arthritis: an interwoven link

    Only recently, the scientific community gained insights on the importance of the intestinal resident flora for the host’s health and disease. Gut microbiota in fact plays a crucial role in modulating innate an...

    Andrea Picchianti Diamanti, M. Manuela Rosado, Bruno Laganà and Raffaele D’Amelio

    Journal of Translational Medicine 2016 14:233

    Published on: 4 August 2016

  14. Research

    Rapid reconstitution of CD4 T cells and NK cells protects against CMV-reactivation after allogeneic stem cell transplantation

    Epstein-Barr virus and Cytomegalovirus reactivations frequently occur after allogeneic stem cell transplantation (SCT).

    Julia Drylewicz, Ingrid M. M. Schellens, Rogier Gaiser, Nening M. Nanlohy, Esther D. Quakkelaar, Henny Otten, Suzanne van Dorp, Ronald Jacobi, Leonie Ran, Sanne Spijkers, Dan Koning, Rob Schuurman, Ellen Meijer, Floortje L. Pietersma, Jurgen Kuball and Debbie van Baarle

    Journal of Translational Medicine 2016 14:230

    Published on: 2 August 2016

  15. Research

    Production of functional, stable, unmutated recombinant human papillomavirus E6 oncoprotein: implications for HPV-tumor diagnosis and therapy

    High-risk human papillomaviruses (HR-HPVs) types 16 and 18 are the main etiological agents of cervical cancer, with more than 550,000 new cases each year worldwide. HPVs are also associated with other ano-geni...

    Elena Illiano, Olivia Costantina Demurtas, Silvia Massa, Paola Di Bonito, Valerio Consalvi, Roberta Chiaraluce, Carlo Zanotto, Carlo De Giuli Morghen, Antonia Radaelli, Aldo Venuti and Rosella Franconi

    Journal of Translational Medicine 2016 14:224

    Published on: 28 July 2016

  16. Research

    A short CD3/CD28 costimulation combined with IL-21 enhance the generation of human memory stem T cells for adoptive immunotherapy

    Immunotherapy based on the adoptive transfer of gene modified T cells is an emerging approach for the induction of tumor-specific immune responses. Memory stem T cells, due to their enhanced antitumor and self...

    C. Alvarez-Fernández, L. Escribà-Garcia, S. Vidal, J. Sierra and J. Briones

    Journal of Translational Medicine 2016 14:214

    Published on: 19 July 2016

  17. Research

    GRIM19 ameliorates acute graft-versus-host disease (GVHD) by modulating Th17 and Treg cell balance through down-regulation of STAT3 and NF-AT activation

    T helper (Th) 17 cells are a subset of T helper cells that express interleukin (IL)-17 and initiate the inflammatory response in autoimmune diseases. Regulatory T cells (Tregs) are a subpopulation of T cells t...

    Min-Jung Park, Seung Hoon Lee, Sung-Hee Lee, Eun-Kyung Kim, Eun Jung Lee, Young-Mee Moon and Mi- La Cho

    Journal of Translational Medicine 2016 14:206

    Published on: 8 July 2016

  18. Research

    Amelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance

    Foxp3 is a key regulator of the development and function of regulatory T cells (Tregs), and its expression is thought to be T cell-restricted. We found that B cells in mice can express Foxp3 and B cells expres...

    Mi Kyung Park, Young Ok Jung, Seon-Yeong Lee, Seung Hoon Lee, Yu Jung Heo, Eun Kyung Kim, Hye Jwa Oh, Young Mee Moon, Hye-Jin Son, Min Jung Park, Sung Hwan Park, Ho Youn Kim, Mi La Cho and Jun Ki Min

    Journal of Translational Medicine 2016 14:191

    Published on: 28 June 2016

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:221

  19. Research

    Rebamipide prevents peripheral arthritis and intestinal inflammation by reciprocally regulating Th17/Treg cell imbalance in mice with curdlan-induced spondyloarthritis

    Spondyloarthritis (SpA) usually manifests as arthritis of the axial and peripheral joints but can also result in extra-articular manifestations such as inflammatory bowel disease. Proinflammatory cytokine inte...

    Hong-Ki Min, Jae-Kyung Kim, Seon-Yeong Lee, Eun-Kyung Kim, Seung Hoon Lee, Jennifer Lee, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park

    Journal of Translational Medicine 2016 14:190

    Published on: 27 June 2016

  20. Research

    TWEAK-binding autoantibodies are generated during psoriatic arthritis and are not influenced by anti-TNF therapy

    TNF weakly inducer of apoptosis (TWEAK) is member of the TNF ligand superfamily. Various data support that TWEAK produced by synovial macrophages may contribute to synovitis observed in psoriatic arthritis (P...

    Sandrine Guis, Philippe Berbis, Delphine Stephan, Daniel Bertin, Florent Amatore, Nathalie Balandraud, Nathalie Lesavre and Sophie Desplat-Jégo

    Journal of Translational Medicine 2016 14:185

    Published on: 23 June 2016

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