Immunobiology and immunotherapy

Section edited by Adrian Bot

This section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Edited by Pedro Romero.

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  1. Review

    The spleen in liver cirrhosis: revisiting an old enemy with novel targets

    The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the ...

    Liang Li, Mubing Duan, Weisan Chen, An Jiang, Xiaoming Li, Jun Yang and Zongfang Li

    Journal of Translational Medicine 2017 15:111

    Published on: 23 May 2017

  2. Research

    A phase II trial of autologous dendritic cell vaccination and radiochemotherapy following fluorescence-guided surgery in newly diagnosed glioblastoma patients

    Prognosis of patients with glioblastoma multiforme (GBM) remains dismal, with median overall survival (OS) of about 15 months. It is therefore crucial to search alternative strategies that improve these result...

    Susana Inogés, Sonia Tejada, Ascensión López-Díaz de Cerio, Jaime Gállego Pérez-Larraya, Jaime Espinós, Miguel Angel Idoate, Pablo Daniel Domínguez, Reyes García de Eulate, Javier Aristu, Maurizio Bendandi, Fernando Pastor, Marta Alonso, Enrique Andreu, Felipe Prósper Cardoso and Ricardo Díez Valle

    Journal of Translational Medicine 2017 15:104

    Published on: 12 May 2017

  3. Research

    Whole blood gene expression in adolescent chronic fatigue syndrome: an exploratory cross-sectional study suggesting altered B cell differentiation and survival

    Chronic fatigue syndrome (CFS) is a prevalent and disabling condition affecting adolescents. The pathophysiology is poorly understood, but immune alterations might be an important component. This study compare...

    Chinh Bkrong Nguyen, Lene Alsøe, Jessica M. Lindvall, Dag Sulheim, Even Fagermoen, Anette Winger, Mari Kaarbø, Hilde Nilsen and Vegard Bruun Wyller

    Journal of Translational Medicine 2017 15:102

    Published on: 11 May 2017

  4. Review

    Anti-inflammatory effects of H2S during acute bacterial infection: a review

    Hydrogen sulfide (H2S), previously only considered a toxic environmental air pollutant, is now increasingly recognized as an important signaling molecule able to modulate several cellular pathways in many human t...

    Francesca Benedetti, Sabrina Curreli, Selvi Krishnan, Sergio Davinelli, Fiorenza Cocchi, Giovanni Scapagnini, Robert C. Gallo and Davide Zella

    Journal of Translational Medicine 2017 15:100

    Published on: 10 May 2017

  5. Research

    Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

    Malignant melanoma is an aggressive tumor sensitive for immunotherapy such as checkpoint blockade antibodies. Still, most patients with late stage disease do not respond, and the side effects can be severe. St...

    A. Schiza, J. Wenthe, S. Mangsbo, E. Eriksson, Anders Nilsson, T. H. Tötterman, A. Loskog and G. Ullenhag

    Journal of Translational Medicine 2017 15:79

    Published on: 20 April 2017

  6. Research

    Levels of hepatic Th17 cells and regulatory T cells upregulated by hepatic stellate cells in advanced HBV-related liver fibrosis

    Liver fibrosis which mainly occurs upon chronic hepatitis virus infection potentially leads to portal hypertension, hepatic failure and hepatocellular carcinoma. However, the immune status of Th17 and Treg cel...

    Xiaoyan Li, Yujie Su, Xuefeng Hua, Chan Xie, Jing Liu, Yuehua Huang, Liang Zhou, Min Zhang, Xu Li and Zhiliang Gao

    Journal of Translational Medicine 2017 15:75

    Published on: 11 April 2017

  7. Research

    Proteomic analysis of protein purified derivative of Mycobacterium bovis

    Tuberculin skin test based on in vivo intradermal inoculation of purified protein derivative from Mycobacterium bovis (bPPD) is the diagnostic test for the control and surveillance of bovine tuberculosis (bTB).

    Sante Roperto, Mariaconcetta Varano, Valeria Russo, Roberta Lucà, Monica Cagiola, Marco Gaspari, Dora Maria Ceccarelli, Giovanni Cuda and Franco Roperto

    Journal of Translational Medicine 2017 15:68

    Published on: 3 April 2017

  8. Research

    TCD4pos lymphocytosis in rheumatoid and psoriatic arthritis patients following TNFα blocking agents

    Lymphocyte expansion and true lymphocytosis are commonly observed in the everyday clinical practice. The meaning of such phenomenon is often poorly understood so that discrimination between benign and malignan...

    Andrea Picchianti Diamanti, Bruno Laganà, Maria Christina Cox, Emanuela Pilozzi, Rachele Amodeo, Maurizio Bove, Milica Markovic, Roberta Di Rosa, Simonetta Salemi, Maria Laura Sorgi, Maria Manuela Rosado and Raffaele D’Amelio

    Journal of Translational Medicine 2017 15:38

    Published on: 21 February 2017

  9. Review

    Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

    Macrophages and neutrophils are key components involved in the regulation of numerous chronic inflammatory diseases, infectious disorders, and especially certain autoimmune disease. However, little is known re...

    Kely Campos Navegantes, Rafaelli de Souza Gomes, Priscilla Aparecida Tártari Pereira, Paula Giselle Czaikoski, Carolina Heitmann Mares Azevedo and Marta Chagas Monteiro

    Journal of Translational Medicine 2017 15:36

    Published on: 15 February 2017

  10. Research

    The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1

    Leflunomide is a low-molecular-weight compound that is widely used in the treatment of rheumatoid arthritis. Although leflunomide is thought to act through the inhibition of the de novo pyrimidine synthesis, t...

    Su-Jin Moon, Eun-Kyung Kim, Joo Yeon Jhun, Hee Jin Lee, Weon Sun Lee, Sang-Hi Park, Mi-La Cho and Jun-Ki Min

    Journal of Translational Medicine 2017 15:31

    Published on: 13 February 2017

  11. Research

    Inhibitory effect of a novel peptide, H-RN, on keratitis induced by LPS or poly(I:C) in vitro and in vivo via suppressing NF-κB and MAPK activation

    Keratitis is a common cause of blindness. Current anti-inflammatory drugs used in keratitis have profound side effects. Small peptides derived from endogenous proteins potentially display both desired efficien...

    Shaopin Zhu, Xun Xu, Lili Wang, Li Su, Qing Gu, Fang Wei and Kun Liu

    Journal of Translational Medicine 2017 15:20

    Published on: 26 January 2017

  12. Research

    Study of the microRNA expression profile of foreskin derived mesenchymal stromal cells following inflammation priming

    Due to their self-renewal capacity, multi-lineage potential, and immunomodulatory properties, mesenchymal stromal cells (MSCs) are an attractive tool for different therapeutic strategies. Foreskin (FSK), consi...

    Hussein Fayyad-Kazan, Mohammad Fayyad-Kazan, Bassam Badran, Dominique Bron, Laurence Lagneaux and Mehdi Najar

    Journal of Translational Medicine 2017 15:10

    Published on: 13 January 2017

  13. Research

    Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response

    Prophylactic and therapeutic vaccines often depend upon a strong activation of the innate immune system to drive a potent adaptive immune response, often mediated by a strong adjuvant. For a number of adjuvant...

    Darin K. Edwards, Edith Jasny, Heesik Yoon, Nigel Horscroft, Brian Schanen, Tanya Geter, Mariola Fotin-Mleczek, Benjamin Petsch and Vaughan Wittman

    Journal of Translational Medicine 2017 15:1

    Published on: 3 January 2017

  14. Research

    Colonization of xenograft tumors by oncolytic vaccinia virus (VACV) results in enhanced tumor killing due to the involvement of myeloid cells

    The mechanisms by which vaccinia virus (VACV) interacts with the innate immune components are complex and involve different mechanisms. iNOS-mediated NO production by myeloid cells is one of the central antivi...

    Mehmet Okyay Kilinc, Klaas Ehrig, Maysam Pessian, Boris R. Minev and Aladar A. Szalay

    Journal of Translational Medicine 2016 14:340

    Published on: 20 December 2016

  15. Research

    Effects by periodontitis on pristane-induced arthritis in rats

    An infection-immune association of periodontal disease with rheumatoid arthritis has been suggested. This study aimed to investigate the effect of pre-existing periodontitis on the development and the immune/i...

    Kaja Eriksson, Erik Lönnblom, Gregory Tour, Anna Kats, Piotr Mydel, Pierre Georgsson, Catharina Hultgren, Nastya Kharlamova, Ulrika Norin, Jörgen Jönsson, Anna Lundmark, Annelie Hellvard, Karin Lundberg, Leif Jansson, Rikard Holmdahl and Tülay Yucel-Lindberg

    Journal of Translational Medicine 2016 14:311

    Published on: 3 November 2016

  16. Research

    Pulsed high-dose dexamethasone modulates Th1-/Th2-chemokine imbalance in immune thrombocytopenia

    Chemokines and chemokine receptors play important roles in autoimmune diseases; however, their role in immune thrombocytopenia (ITP) is unclear. High-dose dexamethasone (HD-DXM) may become a first-line therapy...

    Zongtang Liu, Meiying Wang, Shufen Zhou, Ji Ma, Yan Shi, Jun Peng, Ming Hou and Chengshan Guo

    Journal of Translational Medicine 2016 14:301

    Published on: 24 October 2016

  17. Research

    Discovery of immunodominant T-cell epitopes reveals penton protein as a second immunodominant target in human adenovirus infection

    Human adenovirus (HAdV) infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Efficient antiviral T-cell responses are necessary to clear infect...

    Sabine Tischer, René Geyeregger, Julian Kwoczek, Albert Heim, Constanca Figueiredo, Rainer Blasczyk, Britta Maecker-Kolhoff and Britta Eiz-Vesper

    Journal of Translational Medicine 2016 14:286

    Published on: 7 October 2016

  18. Research

    IL-27 attenuates airway inflammation in a mouse asthma model via the STAT1 and GADD45γ/p38 MAPK pathways

    Asthma is prone to Th2-mediated chronic airway inflammation. Interleukin-27 (IL-27) is a member of the IL-12 family that promotes the differentiation of Th1 cells and inhibits Th2 cells. We use human/mouse CD4+ T...

    Xiaoqiong Su, Jue Pan, Fengxi Bai, Honglei Yuan, Nian Dong, Dandan Li, Xiangdong Wang and Zhihong Chen

    Journal of Translational Medicine 2016 14:283

    Published on: 29 September 2016

  19. Research

    Gemcitabine reduces MDSCs, tregs and TGFβ-1 while restoring the teff/treg ratio in patients with pancreatic cancer

    Cancer immunotherapy can be potentiated by conditioning regimens such as cyclophosphamide, which reduces the level of regulatory T cells (tregs). However, myeloid suppressive cells are still remaining. Accordi...

    Emma Eriksson, Jessica Wenthe, Sandra Irenaeus, Angelica Loskog and Gustav Ullenhag

    Journal of Translational Medicine 2016 14:282

    Published on: 29 September 2016

  20. Research

    In-vitro influence of mycophenolate mofetil (MMF) and Ciclosporin A (CsA) on cytokine induced killer (CIK) cell immunotherapy

    Cytokine-induced-killer (CIK) cells are a promising immunotherapeutic approach for impending relapse following hematopoietic stem cell transplantation (HSCT). However, there is a high risk for treatment failur...

    Melanie Bremm, Sabine Huenecke, Olga Zimmermann, Verena Pfirrmann, Andrea Quaiser, Halvard Bonig, Jan Soerensen, Thomas Klingebiel, Eva Rettinger, Peter Bader and Claudia Cappel

    Journal of Translational Medicine 2016 14:264

    Published on: 13 September 2016

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