Personalized medicine

Section edited by Lotfi Chouchane

This section aims to provide a platform for research that will revolutionize patient care through the use of novel molecular predisposing screening, diagnostic, prognostic and pharmacogenomics. Advances in human genome research are opening the door to a new paradigm for practicing medicine that promises to transform healthcare. Personalized medicine will impact the way that medicine is practiced.

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  1. Research

    Circulating tumor cells capture disease evolution in advanced prostate cancer

    Genetic analysis of advanced cancer is limited by availability of representative tissue. Biopsies of prostate cancer metastasized to bone are invasive with low quantity of tumor tissue. The prostate cancer gen...

    Justin Lack, Marc Gillard, Maggie Cam, Gladell P. Paner and David J. VanderWeele

    Journal of Translational Medicine 2017 15:44

    Published on: 23 February 2017

  2. Research

    Optimized creation of glioblastoma patient derived xenografts for use in preclinical studies

    Glioblastoma multiforme (GBM) is the most common and lethal brain tumor in adults, highlighting the need for novel treatment strategies. Patient derived xenografts (PDX) represent a valuable tool to accomplish...

    Doreen William, Christina Susanne Mullins, Björn Schneider, Andrea Orthmann, Nora Lamp, Mathias Krohn, Annika Hoffmann, Carl-Friedrich Classen and Michael Linnebacher

    Journal of Translational Medicine 2017 15:27

    Published on: 9 February 2017

  3. Research

    GNAS mutations as prognostic biomarker in patients with relapsed peritoneal pseudomyxoma receiving metronomic capecitabine and bevacizumab: a clinical and translational study

    There is lack of evidence about systemic treatment of pseudomyxoma peritonei (PMP) relapsing after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. There is also lack of biomarkers able to ...

    Filippo Pietrantonio, Rosa Berenato, Claudia Maggi, Marta Caporale, Massimo Milione, Federica Perrone, Elena Tamborini, Dario Baratti, Shigeki Kusamura, Luigi Mariani, Monica Niger, Alessia Mennitto, Annunziata Gloghini, Ilaria Bossi, Giulio Settanni, Adele Busico…

    Journal of Translational Medicine 2016 14:125

    Published on: 6 May 2016

  4. Research

    Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples

    Colorectal cancer (CRC) is a heterogeneous disease with different molecular characteristics associated with many variables such as the sites from which the tumors originate or the presence or absence of chromo...

    Ashraf Dallol, Abdelbaset Buhmeida, Mahmoud Shaheen Al-Ahwal, Jaudah Al-Maghrabi, Osama Bajouh, Shadi Al-Khayyat, Rania Alam, Atlal Abusanad, Rola Turki, Aisha Elaimi, Hani A. Alhadrami, Mohammed Abuzenadah, Huda Banni, Mohammed H. Al-Qahtani and Adel M. Abuzenadah

    Journal of Translational Medicine 2016 14:118

    Published on: 4 May 2016

  5. Research

    Testing chemotherapy efficacy in HER2 negative breast cancer using patient-derived spheroids

    Targeted anti-HER2 therapy has greatly improved the prognosis for many breast cancer patients. However, treatment for HER2 negative disease is currently still selected from a multitude of untargeted chemothera...

    Kathrin Halfter, Oliver Hoffmann, Nina Ditsch, Mareike Ahne, Frank Arnold, Stefan Paepke, Dieter Grab, Ingo Bauerfeind and Barbara Mayer

    Journal of Translational Medicine 2016 14:112

    Published on: 3 May 2016

  6. Research

    Pharmacogenetics driving personalized medicine: analysis of genetic polymorphisms related to breast cancer medications in Italian isolated populations

    Breast cancer is the most common cancer in women characterized by a high variable clinical outcome among individuals treated with equivalent regimens and novel targeted therapies. In this study, we performed a...

    Massimiliano Cocca, Davide Bedognetti, Martina La Bianca, Paolo Gasparini and Giorgia Girotto

    Journal of Translational Medicine 2016 14:22

    Published on: 22 January 2016

  7. Research

    Anti-cytokine autoantibodies in postherpetic neuralgia

    The mechanisms by which varicella zoster virus (VZV) reactivation causes postherpetic neuralgia (PHN), a debilitating chronic pain condition, have not been fully elucidated. Based on previous studies identifyi...

    Ahmad Bayat, Peter D. Burbelo, Sarah K. Browne, Mark Quinlivan, Bianca Martinez, Steven M. Holland, Asokumar Buvanendran, Jeffrey S. Kroin, Andrew J. Mannes, Judith Breuer, Jeffrey I. Cohen and Michael J. Iadarola

    Journal of Translational Medicine 2015 13:333

    Published on: 20 October 2015

  8. Research

    In vitro response pattern of monocytes after tmTNF reverse signaling predicts response to anti-TNF therapy in rheumatoid arthritis

    Treatment with TNF inhibitors is very efficient in the majority of the patients with rheumatoid arthritis (RA), but it does not achieve a sufficient treatment response in 40–50% of the cases. Goal of the study...

    Undine Meusch, Marco Krasselt, Manuela Rossol, Christoph Baerwald, Maria Klingner and Ulf Wagner

    Journal of Translational Medicine 2015 13:256

    Published on: 7 August 2015

  9. Research

    Plasma mRNA expression levels of BRCA1 and TS as potential predictive biomarkers for chemotherapy in gastric cancer

    Personalized chemotherapy based on predictive biomarkers can maximize efficacy. However, tumor tissue obtained at the time of initial diagnosis will not reflect genetic alterations observed at the time of dise...

    Jie Shen, Jia Wei, Wenxian Guan, Hao Wang, Yitao Ding, Xiaoping Qian, Lixia Yu, Zhengyun Zou, Li Xie, Carlota Costa, Trever Bivona, Rafael Rosell and Baorui Liu

    Journal of Translational Medicine 2014 12:355

    Published on: 14 December 2014

  10. Research

    Molecular epidemiology and genotype distribution of Human Papillomavirus (HPV) among Arab women in the state of Qatar

    Human Papilloma Virus (HPV) infection is the major cause of cervical cancer worldwide. With limited data available on HPV prevalence in the Arab countries, this study aimed to identify the prevalence and genot...

    Devendra Bansal, Asha A Elmi, Sini Skariah, Pascale Haddad, Laith J Abu-Raddad, Aysha H Al Hamadi, Nady Mohamed-Nady, Nahla M Affifi, Randa Ghedira, Elham Hassen, Asma AJ Al-Thani, Afaf AHM Al-Ansari and Ali A Sultan

    Journal of Translational Medicine 2014 12:300

    Published on: 26 November 2014

  11. Research

    High-throughput profiling identifies clinically actionable mutations in salivary duct carcinoma

    Salivary duct carcinoma (SDC) is a highly aggressive subtype of salivary gland cancers and there is no established standard therapy for this disease. Thus, development of molecular markers for SDC will be impo...

    Bo Mi Ku, Hyun Ae Jung, Jong-Mu Sun, Young Hyeh Ko, Han-Sin Jeong, Young-Ik Son, Chung-Hwan Baek, Keunchil Park and Myung-Ju Ahn

    Journal of Translational Medicine 2014 12:299

    Published on: 25 October 2014

  12. Commentary

    Genetics and primary care: where are we headed?

    Since first sequencing the human genome in 2003, emerging genetic/genomic technologies have ushered in a revolutionary era of medicine that purports to bridge molecular biology and clinical care. The field of ...

    Vasiliki Rahimzadeh and Gillian Bartlett

    Journal of Translational Medicine 2014 12:238

    Published on: 28 August 2014

  13. Protocol

    Cohort profile: Greifswald approach to individualized medicine (GANI_MED)

    Individualized Medicine aims at providing optimal treatment for an individual patient at a given time based on his specific genetic and molecular characteristics. This requires excellent clinical stratificatio...

    Hans J Grabe, Heinrich Assel, Thomas Bahls, Marcus Dörr, Karlhans Endlich, Nicole Endlich, Pia Erdmann, Ralf Ewert, Stephan B Felix, Beate Fiene, Tobias Fischer, Steffen Flessa, Nele Friedrich, Mariacarla Gadebusch-Bondio, Manuela Gesell Salazar, Elke Hammer…

    Journal of Translational Medicine 2014 12:144

    Published on: 23 May 2014

  14. Research

    In silico modeling predicts drug sensitivity of patient-derived cancer cells

    Glioblastoma (GBM) is an aggressive disease associated with poor survival. It is essential to account for the complexity of GBM biology to improve diagnostic and therapeutic strategies. This complexity is best...

    Sandeep C Pingle, Zeba Sultana, Sandra Pastorino, Pengfei Jiang, Rajesh Mukthavaram, Ying Chao, Ila Sri Bharati, Natsuko Nomura, Milan Makale, Taher Abbasi, Shweta Kapoor, Ansu Kumar, Shahabuddin Usmani, Ashish Agrawal, Shireen Vali and Santosh Kesari

    Journal of Translational Medicine 2014 12:128

    Published on: 21 May 2014

  15. Research

    Intratumoral distribution of EGFR mutations and copy number in metastatic lung cancer, what impact on the initial molecular diagnosis?

    Activating epidermal growth factor receptor (EGFR) mutations characterize a subgroup of non-small-cell lung cancer that benefit from first line EGFR tyrosine kinase inhibitors (EGFR-TKI). However, the existence o...

    Audrey Mansuet-Lupo, Fouzia Zouiti, Marco Alifano, Anne Tallet, Marie-Christine Charpentier, Véronique Ducruit, Fabrice Devez, Fanny Lemaitre, Pierre Laurent-Puig, Diane Damotte and Hélène Blons

    Journal of Translational Medicine 2014 12:131

    Published on: 16 May 2014

  16. Research

    Genetic variability of the core protein in hepatitis C virus genotype 4 in Saudi Arabian patients and its implication on pegylated interferon and ribavirin therapy

    Hepatitis C virus (HCV) shows a remarkable genetic diversity, contributing to its high persistence and varied susceptibilities to antiviral treatment. Previous studies have reported that the substitution of am...

    Fatimah S Alhamlan, Mohammed N Al-Ahdal, Nisreen Z Khalaf, Ayman A Abdo, Faisal M Sanai, Hamad I Al-Ashgar, Mahmoud ElHefnawi, Amina Zaid and Ahmed A Al-Qahtani

    Journal of Translational Medicine 2014 12:91

    Published on: 6 April 2014

  17. Research

    PTPRO promoter methylation is predictive of poorer outcome for HER2-positive breast cancer: indication for personalized therapy

    Protein Tyrosine Phosphatase Receptor-type O (PTPRO) has recently been in the spotlight as a tumor suppressor, whose encoding gene is frequently methylated in cancers. We examined the methylation status of the...

    Yi-Teng Huang, Fei-Fei Li, Chen Ke, Zhou Li, Zong-Tai Li, Xiao-Fang Zou, Xiao-Xuan Zheng, Yu-Ping Chen and Hao Zhang

    Journal of Translational Medicine 2013 11:245

    Published on: 3 October 2013

  18. Research

    The AKT inhibitor AZD5363 is selectively active in PI3KCA mutant gastric cancer, and sensitizes a patient-derived gastric cancer xenograft model with PTEN loss to Taxotere

    Activation of the PI3K/AKT pathway is a common phenomenon in cancer due to multiple mechanisms, including mutation of PI3KCA, loss or mutation of PTEN, or over-expression of receptor tyrosine kinases. We recen...

    Jing Li, Barry R Davies, Sufang Han, Minhua Zhou, Yu Bai, Jingchuan Zhang, Yan Xu, Lily Tang, Huiying Wang, Yuan Jie Liu, Xiaolu Yin, Qunsheng Ji and De-Hua Yu

    Journal of Translational Medicine 2013 11:241

    Published on: 2 October 2013

  19. Research

    Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors

    Malignant peripheral nerve sheath tumors (MPNST) are rare highly aggressive sarcomas that affect 8-13% of people with neurofibromatosis type 1. The prognosis for patients with MPNST is very poor. Despite TOP2A...

    Jacqueline D Peacock, David Cherba, Kevin Kampfschulte, Mallory K Smith, Noel R Monks, Craig P Webb and Matthew Steensma

    Journal of Translational Medicine 2013 11:213

    Published on: 17 September 2013

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