Nutrition & metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

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  1. Research

    Hyperbranched polyglycerol is superior to glucose for long-term preservation of peritoneal membrane in a rat model of chronic peritoneal dialysis

    Replacing glucose with a better biocompatible osmotic agent in peritoneal dialysis (PD) solutions is needed in PD clinic. We previously demonstrated the potential of hyperbranched polyglycerol (HPG) as a repla...

    Caigan Du, Asher A. Mendelson, Qiunong Guan, Ghida Dairi, Irina Chafeeva, Gerald da Roza and Jayachandran N. Kizhakkedathu

    Journal of Translational Medicine 2016 14:338

    Published on: 13 December 2016

  2. Review

    Microbiota and neurologic diseases: potential effects of probiotics

    The microbiota colonizing the gastrointestinal tract have been associated with both gastrointestinal and extra-gastrointestinal diseases. In recent years, considerable interest has been devoted to their role i...

    Giulia Umbrello and Susanna Esposito

    Journal of Translational Medicine 2016 14:298

    Published on: 19 October 2016

  3. Research

    Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males

    Intermittent fasting (IF) is an increasingly popular dietary approach used for weight loss and overall health. While there is an increasing body of evidence demonstrating beneficial effects of IF on blood lipi...

    Tatiana Moro, Grant Tinsley, Antonino Bianco, Giuseppe Marcolin, Quirico Francesco Pacelli, Giuseppe Battaglia, Antonio Palma, Paulo Gentil, Marco Neri and Antonio Paoli

    Journal of Translational Medicine 2016 14:290

    Published on: 13 October 2016

  4. Research

    The fibrolytic potentials of vitamin D and thymoquinone remedial therapies: insights from liver fibrosis established by CCl4 in rats

    Vitamin D (VitD) and thymoquinone (TQ) are nutraceutical agents with well-known immunomodulatory and hepatoprotective properties. This study measured whether VitD and TQ, individually or combined, could have d...

    Abdelghany Hassan Abdelghany, Mohammad A. BaSalamah, Shakir Idris, Jawwad Ahmad and Bassem Refaat

    Journal of Translational Medicine 2016 14:281

    Published on: 29 September 2016

  5. Research

    Moniliformediquinone as a potential therapeutic agent, inactivation of hepatic stellate cell and inhibition of liver fibrosis in vivo

    Moniliformediquinone (MFD), a phenanthradiquinone in Dendrobium moniliforme, was synthesized in our laboratory. Beyond its in vitro inhibitory effects on cancer cells, other biological activity of MFD is unknown....

    Tsui-Hwa Tseng, Wea-Lung Lin, Zi-Hui Chen, Yean-Jang Lee, Ming-Shiun Shie, Kam-Fai Lee, Chien-Heng Shen and Hsing-Chun Kuo

    Journal of Translational Medicine 2016 14:263

    Published on: 9 September 2016

  6. Research

    Triglyceride glucose-waist circumference, a novel and effective predictor of diabetes in first-degree relatives of type 2 diabetes patients: cross-sectional and prospective cohort study

    Body mass index (BMI), waist circumference (WC), visceral adiposity index (VAI), triglyceride glucose index (TyG), TyG-BMI, and TyG-WC have been reported as markers of insulin resistance or type 2 diabetes mel...

    Shuang Zheng, Sheng Shi, Xingxing Ren, Tingting Han, Yangxue Li, Yawen Chen, Wei Liu, Peter C. Hou and Yaomin Hu

    Journal of Translational Medicine 2016 14:260

    Published on: 7 September 2016

  7. Protocol

    Modulation of endogenous antioxidant defense and the progression of kidney disease in multi-heritage groups of patients with type 2 diabetes: PRospective EValuation of Early Nephropathy and its Treatment (PREVENT)

    Diabetes is the western world’s leading cause of end-stage renal disease. Glucose-dependent, oxidative stress is linked to the development of renal inflammation and sclerosis, which, in animal models of diabet...

    Kenneth A. Earle, Karima Zitouni, John Pepe, Maria Karaflou and James Godbold

    Journal of Translational Medicine 2016 14:234

    Published on: 4 August 2016

  8. Research

    The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism

    Potentiation of glucose-induced insulin secretion is the main mechanism of exenatide (EXE) antidiabetic action, however, increased glucose utilization by peripheral tissues has been also reported. We here stud...

    Francesco Andreozzi, Gregory Alexander Raciti, Cecilia Nigro, Gaia Chiara Mannino, Teresa Procopio, Alberto M. Davalli, Francesco Beguinot, Giorgio Sesti, Claudia Miele and Franco Folli

    Journal of Translational Medicine 2016 14:229

    Published on: 30 July 2016

  9. Research

    Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study

    Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the intera...

    Federica Rizzi, Costanza Conti, Elena Dogliotti, Annalisa Terranegra, Erika Salvi, Daniele Braga, Flavia Ricca, Sara Lupoli, Alessandra Mingione, Francesca Pivari, Caterina Brasacchio, Matteo Barcella, Martina Chittani, Francesca D’Avila, Maurizio Turiel, Monica Lazzaroni…

    Journal of Translational Medicine 2016 14:186

    Published on: 23 June 2016

  10. Research

    Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome

    Obesity, metabolic syndrome (MetS), and psoriasis, largely driven by environmental factors, show multiple bidirectional associations, with important metabolic implications in psoriatic patients. Besides body m...

    Luigi Barrea, Paolo Emidio Macchia, Carolina Di Somma, Maddalena Napolitano, Anna Balato, Andrea Falco, Maria Cristina Savanelli, Nicola Balato, Annamaria Colao and Silvia Savastano

    Journal of Translational Medicine 2016 14:130

    Published on: 10 May 2016

  11. Research

    Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade

    Hericium erinaceus is an edible mushroom; its various pharmacological effects which have been investigated. This study aimed to demonstrate whether efficacy of oral administration of H...

    Hsing-Chun Kuo, Chien-Chang Lu, Chien-Heng Shen, Shui-Yi Tung, Meng Chiao Hsieh, Ko-Chao Lee, Li-Ya Lee, Chin-Chu Chen, Chih-Chuan Teng, Wen-Shih Huang, Te-Chuan Chen and Kam-Fai Lee

    Journal of Translational Medicine 2016 14:78

    Published on: 18 March 2016

  12. Review

    Obesity and colorectal cancer: molecular features of adipose tissue

    The huge part of population in developed countries is overweight or obese. Obesity is often determined by body mass index (BMI) but new accurate methods and ratios have recently appeared to measure body fat or...

    Javier Martinez-Useros and Jesus Garcia-Foncillas

    Journal of Translational Medicine 2016 14:21

    Published on: 22 January 2016

  13. Research

    Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation

    Naturally occurring polyphenolic compounds from fruits, particularly from blueberries, have been reported to be significantly involved in cancer chemoprevention and chemotherapy. Biotransformation of blueberry...

    Tri Vuong, Jean-François Mallet, Maria Ouzounova, Sam Rahbar, Hector Hernandez-Vargas, Zdenko Herceg and Chantal Matar

    Journal of Translational Medicine 2016 14:13

    Published on: 14 January 2016

  14. Review

    Insulin-like growth factor-1 deficiency and metabolic syndrome

    Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impai...

    G. A. Aguirre, J. Rodríguez De Ita, R. G. de la Garza and I. Castilla-Cortazar

    Journal of Translational Medicine 2016 14:3

    Published on: 6 January 2016

  15. Research

    Chronic administration of the probiotic kefir improves the endothelial function in spontaneously hypertensive rats

    The beverage obtained by fermentation of milk with kefir grains, a complex matrix containing acid bacteria and yeasts, has been shown to have beneficial effects in various diseases. However, its effects on hyp...

    Andreia G. F. Friques, Clarisse M. Arpini, Ieda C. Kalil, Agata L. Gava, Marcos A. Leal, Marcella L. Porto, Breno V. Nogueira, Ananda T. Dias, Tadeu U. Andrade, Thiago Melo C. Pereira, Silvana S. Meyrelles, Bianca P. Campagnaro and Elisardo C. Vasquez

    Journal of Translational Medicine 2015 13:390

    Published on: 30 December 2015

  16. Research

    Low 25(OH) D serum levels are related with hip fracture in postmenopausal women: a matched case–control study

    There is limited information on the prevalence of vitamin D deficiency among patients diagnosed with hip fracture in the Chinese Han population. Therefore, the aim of this study was to assess the effects of ch...

    Xing-Mao Fu, Shao-Guang Fan, Shu-Liang Li, Yi-Sheng Chen, Hai Wu and Yan-Long Guo

    Journal of Translational Medicine 2015 13:388

    Published on: 23 December 2015

  17. Research

    Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue

    A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue.

    Eduardo García-Fuentes, Concepción Santiago-Fernández, Carolina Gutiérrez-Repiso, María D. Mayas, Wilfredo Oliva-Olivera, Leticia Coín-Aragüez, Juan Alcaide, Luis Ocaña-Wilhelmi, Joan Vendrell, Francisco J. Tinahones and Lourdes Garrido-Sánchez

    Journal of Translational Medicine 2015 13:373

    Published on: 30 November 2015

  18. Research

    Understanding the molecular aspects of oriental obesity pattern differentiation using DNA microarray

    Human constitution, the fundamental basis of oriental medicine, is categorized into different patterns for a particular disease according to the physical, physiological, and clinical characteristics of the ind...

    Sun Woo Hong, Jae-Wook Yoo, Shambhunath Bose, Jung-Hyun Park, Kyungsun Han, Soyoun Kim, Chi-Yeon Lim, Hojun Kim and Dong-ki Lee

    Journal of Translational Medicine 2015 13:331

    Published on: 19 October 2015

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