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  1. Research

    Dynamic and specific immune responses against multiple tumor antigens were elicited in patients with hepatocellular carcinoma after cell-based immunotherapy

    Hepatocellular carcinoma (HCC) is one of the most common cancers in China and frequently occurs with chronic hepatitis B virus infection. To investigate whether cell-based cancer immunotherapy induces tumor sp...

    Yanyan Han, Yeting Wu, Chou Yang, Jing Huang, Yabing Guo, Li Liu, Ping Chen, Dongyun Wu, Junyun Liu, Jin Li, Xiangjun Zhou and Jinlin Hou

    Journal of Translational Medicine 2017 15:64

    Published on: 22 March 2017

  2. Research

    Urinary collagen degradation products as early markers of progressive renal fibrosis

    Renal fibrogenesis is associated with increased ECM remodeling and release of collagen fragments in urine in progressive renal disease. We investigated the diagnostic value of urinary collagen degradation prod...

    Ryanne S. Hijmans, Daniel Guldager Kring Rasmussen, Saleh Yazdani, Gerjan Navis, Harry van Goor, Morten Asser Karsdal, Federica Genovese and Jacob van den Born

    Journal of Translational Medicine 2017 15:63

    Published on: 20 March 2017

  3. Research

    Epidermal growth factor receptor and epididymis invasion as prognostic biomarkers in clinical stage I testicular germ cell tumours

    Inguinal orchiectomy is curative in 70–80% of clinical stage I testicular germ cell tumours (CS I TGCT). The identification of patients who are at low risk of relapse is critical to avoid unnecessary treatment...

    Miguel F. Sanmamed, E. Esteban, E. Uriol, R. Zarate, M. Capelan, C. Muriel, G. Crespo, J. P. Berros, P. Pardo-Coto, Q. Perez, C. Alvarez-Fernández, P. Jiménez Fonseca, M. Luque and A. Astudillo

    Journal of Translational Medicine 2017 15:62

    Published on: 20 March 2017

  4. Research

    Veliparib in combination with radiotherapy for the treatment of MGMT unmethylated glioblastoma

    The O 6 -methylguanine methyltransferase (MGMT) gene is frequently unmethylated in patients with glioblastoma (GBM), rendering them non-responsive...

    Toni Rose Jue, Kyoko Nozue, Ashleigh J. Lester, Swapna Joshi, Lisette B. W. Schroder, Shane P. Whittaker, Sheri Nixdorf, Robert W. Rapkins, Mustafa Khasraw and Kerrie L. McDonald

    Journal of Translational Medicine 2017 15:61

    Published on: 17 March 2017

  5. Research

    Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells

    Clinical trials of Chimeric Antigen Receptor (CAR) T cells manufactured from autologous peripheral blood mononuclear cell (PBMC) concentrates for the treatment of hematologic malignancies have been promising, ...

    David F. Stroncek, Daniel W. Lee, Jiaqiang Ren, Marianna Sabatino, Steven Highfill, Hanh Khuu, Nirali N. Shah, Rosandra N. Kaplan, Terry J. Fry and Crystal L. Mackall

    Journal of Translational Medicine 2017 15:59

    Published on: 16 March 2017

  6. Research

    Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study

    Investigations of activin family proteins as serum biomarkers for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). CFS/ME is a disease with complex, wide-ranging symptoms, featuring persistent fati...

    Brett A. Lidbury, Badia Kita, Donald P. Lewis, Susan Hayward, Helen Ludlow, Mark P. Hedger and David M. de Kretser

    Journal of Translational Medicine 2017 15:60

    Published on: 16 March 2017

  7. Research

    FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model

    Malignant mesothelioma (MM) is a very aggressive type of cancer, with a dismal prognosis and inherent resistance to chemotherapeutics. Development and evaluation of new therapeutic approaches is highly needed....

    Agata Szymiczek, Sandra Pastorino, David Larson, Mika Tanji, Laura Pellegrini, Jiaming Xue, Shuangjing Li, Carlotta Giorgi, Paolo Pinton, Yasutaka Takinishi, Harvey I. Pass, Hideki Furuya, Giovanni Gaudino, Andrea Napolitano, Michele Carbone and Haining Yang

    Journal of Translational Medicine 2017 15:58

    Published on: 15 March 2017

  8. Research

    Aberrant T cell responses in the bone marrow microenvironment of patients with poor graft function after allogeneic hematopoietic stem cell transplantation

    Poor graft function (PGF) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Nevertheless, whether abnormalities of T cell subsets in the bone marrow (BM)...

    Yuan Kong, Yu-Tong Wang, Xie-Na Cao, Yang Song, Yu-Hong Chen, Yu-Qian Sun, Yu Wang, Xiao-Hui Zhang, Lan-Ping Xu and Xiao-Jun Huang

    Journal of Translational Medicine 2017 15:57

    Published on: 14 March 2017

  9. Research

    Non-invasive in vivo imaging of cardiac stem/progenitor cell biodistribution and retention after intracoronary and intramyocardial delivery in a swine model of chronic ischemia reperfusion injury

    The safety and efficacy of cardiac stem/progenitor cells (CSC) have been demonstrated in previous preclinical and clinical assays for heart failure. However, their optimal delivery route to the ischemic heart ...

    María Collantes, Beatriz Pelacho, María José García-Velloso, Juán José Gavira, Gloria Abizanda, Itziar Palacios, Luis Rodriguez-Borlado, Virginia Álvarez, Elena Prieto, Margarita Ecay, Eduardo Larequi, Iván Peñuelas and Felipe Prósper

    Journal of Translational Medicine 2017 15:56

    Published on: 13 March 2017

  10. Research

    Hyperglycemia enhances arsenic-induced platelet and megakaryocyte activation

    Low to moderate inorganic arsenic (iAs) exposure is independently associated with cardiovascular disease (CVD), particularly for patients with diabetes mellitus (DM). The mechanism of increased CVD risk from i...

    Jonathan D. Newman, Christina T. Echagarruga, Yoscar M. Ogando, Emilie Montenont, Yu Chen, Edward A. Fisher and Jeffrey S. Berger

    Journal of Translational Medicine 2017 15:55

    Published on: 6 March 2017

  11. Research

    Endothelial and smooth muscle cells derived from human cardiac explants demonstrate angiogenic potential and suitable for design of cell-containing vascular grafts

    Endothelial and smooth muscle cells are considered promising resources for regenerative medicine and cell replacement therapy. It has been shown that both types of cells are heterogeneous depending on the type...

    I. S. Zakharova, M. K. Zhiven’, Sh. B. Saaya, A. I. Shevchenko, A. M. Smirnova, A. Strunov, A. A. Karpenko, E. A. Pokushalov, L. N. Ivanova, P. I. Makarevich, Y. V. Parfyonova, E. Aboian and S. M. Zakian

    Journal of Translational Medicine 2017 15:54

    Published on: 3 March 2017

  12. Research

    Stability of pro- and anti-inflammatory immune biomarkers for human cohort studies

    Although discovery research has identified the importance of dozens of pro- and anti-inflammatory immune mediators in the pathogenesis, maintenance, exacerbation and resolution of inflammatory diseases, most h...

    C. Graham, R. Chooniedass, W. P. Stefura, L. Lotoski, P. Lopez, A. D. Befus, A. B. Becker and K. T. HayGlass

    Journal of Translational Medicine 2017 15:53

    Published on: 2 March 2017

  13. Erratum

    Erratum to: Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study

    Sarah H. White, Mary M. McDermott, Robert L. Sufit, Kate Kosmac, Alex W. Bugg, Marta Gonzalez-Freire, Luigi Ferrucci, Lu Tian, Lihui Zhao, Ying Gao, Melina R. Kibbe, Michael H. Criqui, Christiaan Leeuwenburgh and Charlotte A. Peterson

    Journal of Translational Medicine 2017 15:45

    Published on: 28 February 2017

    The original article was published in Journal of Translational Medicine 2016 14:284

  14. Research

    Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway

    Gastric cancer (GC) is one of the most malignant tumors and the second leading cause of cancer-related deaths in the world. Luteolin, a flavonoid present in many fruits and green plants, suppresses cancer prog...

    Ming-de Zang, Lei Hu, Zhi-yuan Fan, He-xiao Wang, Zheng-lun Zhu, Shu Cao, Xiong-yan Wu, Jian-fang Li, Li-ping Su, Chen Li, Zheng-gang Zhu, Min Yan and Bing-ya Liu

    Journal of Translational Medicine 2017 15:52

    Published on: 27 February 2017

  15. Review

    Heterogeneity of Toll-like receptor 9 signaling in B cell malignancies and its potential therapeutic application

    Toll-like receptor 9 (TLR9) is expressed in a variety of B-cell malignancies and works as a bridge between innate and adaptive immunity. CpG oligodeoxynucleotides (CpG ODNs), TLR9 agonists, are able to induce ...

    Ling Bai, Wei Chen, Jingtao Chen, Wei Li, Lei Zhou, Chao Niu, Wei Han and Jiuwei Cui

    Journal of Translational Medicine 2017 15:51

    Published on: 27 February 2017

  16. Research

    A rabbit model for experimental alveolar cleft grafting

    The purpose of the present study was to develop an animal model for creating alveolar cleft defects with properly simulated clinical defect environment for tissue-engineered bone-substitute materials testing w...

    Mohammad Kamal, Lars Andersson, Rene Tolba, Alexander Bartella, Felix Gremse, Frank Hölzle, Peter Kessler and Bernd Lethaus

    Journal of Translational Medicine 2017 15:50

    Published on: 24 February 2017

  17. Review

    Therapeutic strategies for cell-based neovascularization in critical limb ischemia

    Critical limb ischemia (CLI) causes severe ischemic rest pain, ulcer, and gangrene in the lower limbs. In spite of angioplasty and surgery, CLI patients without suitable artery inflow or enough vascular bed in...

    Makoto Samura, Tohru Hosoyama, Yuriko Takeuchi, Koji Ueno, Noriyasu Morikage and Kimikazu Hamano

    Journal of Translational Medicine 2017 15:49

    Published on: 24 February 2017

  18. Research

    Comparative analysis of curative effect of bone marrow mesenchymal stem cell and bone marrow mononuclear cell transplantation for spastic cerebral palsy

    Bone marrow mesenchymal stem cells (BMMSCs) and bone marrow mononuclear cells (BMMNCs) are both used to treat spastic cerebral palsy. However, the differences in therapeutic effect remain unknown.

    Xuebin Liu, Xiaojun Fu, Guanghui Dai, Xiaodong Wang, Zan Zhang, Hongbin Cheng, Pei Zheng and Yihua An

    Journal of Translational Medicine 2017 15:48

    Published on: 24 February 2017

  19. Research

    Circulating tumor cells capture disease evolution in advanced prostate cancer

    Genetic analysis of advanced cancer is limited by availability of representative tissue. Biopsies of prostate cancer metastasized to bone are invasive with low quantity of tumor tissue. The prostate cancer gen...

    Justin Lack, Marc Gillard, Maggie Cam, Gladell P. Paner and David J. VanderWeele

    Journal of Translational Medicine 2017 15:44

    Published on: 23 February 2017

  20. Research

    Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma

    Imatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4...

    Mikhail Burmakin, Tijs van Wieringen, P. Olof Olsson, Linda Stuhr, Aive Åhgren, Carl-Henrik Heldin, Rolf K. Reed, Kristofer Rubin and Carina Hellberg

    Journal of Translational Medicine 2017 15:47

    Published on: 23 February 2017

  21. Research

    COX-2 expression positively correlates with PD-L1 expression in human melanoma cells

    The resistance to PD-1/PD-L1 inhibitors for the treatment of melanoma have prompted investigators to implement novel clinical trials which combine immunotherapy with different treatment modalities. Moreover is...

    Gerardo Botti, Federica Fratangelo, Margherita Cerrone, Giuseppina Liguori, Monica Cantile, Anna Maria Anniciello, Stefania Scala, Crescenzo D’Alterio, Chiara Trimarco, Angela Ianaro, Giuseppe Cirino, Corrado Caracò, Maria Colombino, Giuseppe Palmieri, Stefano Pepe, Paolo Antonio Ascierto…

    Journal of Translational Medicine 2017 15:46

    Published on: 23 February 2017

  22. Meeting abstracts

    Proceedings of the 4th Annual United States Army Institute of Surgical Research Summer Undergraduate Research Internship Program 2016

    Lauren E. Cornell, Whitney Greene, Rachel O. Haich, Lee C. Mangum, Gerardo R. Garcia, Charles H. Guymon, Kevin S. Akers, Jennifer Landry, Jennifer McDaniel, Gina Griffith, Elaine Por, David Rios, David Zamora, Brian Lund, Alexandra M. Forbes, Joel D. Newton…

    Journal of Translational Medicine 2017 15(Suppl 2):19

    Published on: 22 February 2017

    This article is part of a Supplement: Volume 15 Supplement 2

  23. Research

    TCD4pos lymphocytosis in rheumatoid and psoriatic arthritis patients following TNFα blocking agents

    Lymphocyte expansion and true lymphocytosis are commonly observed in the everyday clinical practice. The meaning of such phenomenon is often poorly understood so that discrimination between benign and malignan...

    Andrea Picchianti Diamanti, Bruno Laganà, Maria Christina Cox, Emanuela Pilozzi, Rachele Amodeo, Maurizio Bove, Milica Markovic, Roberta Di Rosa, Simonetta Salemi, Maria Laura Sorgi, Maria Manuela Rosado and Raffaele D’Amelio

    Journal of Translational Medicine 2017 15:38

    Published on: 21 February 2017

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