Articles

Sort by
Previous Page Page 1 of 117 Next Page
  1. Methodology

    Lymph node pooling: a feasible and efficient method of lymph node molecular staging in colorectal carcinoma

    Pathologic lymph node staging is becoming a deficient method in the demanding molecular era. Nevertheless, the use of more sensitive molecular analysis for nodal staging is hampered by its high costs and exte...

    Natalia Rakislova, Carla Montironi, Iban Aldecoa, Eva Fernandez, Josep Antoni Bombi, Mireya Jimeno, Francesc Balaguer, Maria Pellise, Antoni Castells and Miriam Cuatrecasas

    Journal of Translational Medicine 2017 15:14

    Published on: 14 January 2017

  2. Research

    Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility

    The gastrointestinal motility is affected by gut microbiota and the relationship between them has become a hot topic. However, mechanisms of microbiota in regulating motility have not been well defined. We thu...

    Xiaolong Ge, Chao Ding, Wei Zhao, Lizhi Xu, Hongliang Tian, Jianfeng Gong, Minsheng Zhu, Jieshou Li and Ning Li

    Journal of Translational Medicine 2017 15:13

    Published on: 13 January 2017

  3. Research

    Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease

    Stromal vascular fraction (SVF) can easily be obtained from a mini-lipoaspirate procedure of fat tissue and platelet rich plasma (PRP) can be obtained from peripheral blood. The SVF contains a mixture of cells...

    Comella Kristin, Silbert Robert and Parlo Michelle

    Journal of Translational Medicine 2017 15:12

    Published on: 13 January 2017

  4. Research

    B cell repertoires in HLA-sensitized kidney transplant candidates undergoing desensitization therapy

    Kidney transplantation is the most effective treatment for end-stage renal disease. Sensitization refers to pre-existing antibodies against human leukocyte antigen (HLA) protein and remains a major barrier to ...

    John F. Beausang, H. Christina Fan, Rene Sit, Maria U. Hutchins, Kshama Jirage, Rachael Curtis, Edward Hutchins, Stephen R. Quake and Julie M. Yabu

    Journal of Translational Medicine 2017 15:9

    Published on: 13 January 2017

  5. Research

    Inhibitory effects of serum from sepsis patients on epithelial cell migration in vitro: a case control study

    Sepsis delays wound re-epithelialization. In this study we explored the effect of human sepsis sera as well as the effects of cytokines, growth factors and exosomes of sepsis sera treated normal fibroblasts (N...

    Henna Jaurila, Vesa Koivukangas, Marjo Koskela, Fiia Gäddnäs, Sirpa Salo, Johanna Korvala, Maija Risteli, Toni Karhu, Karl-Heinz Herzig, Tuula Salo and Tero I. Ala-Kokko

    Journal of Translational Medicine 2017 15:11

    Published on: 13 January 2017

  6. Research

    Study of the microRNA expression profile of foreskin derived mesenchymal stromal cells following inflammation priming

    Due to their self-renewal capacity, multi-lineage potential, and immunomodulatory properties, mesenchymal stromal cells (MSCs) are an attractive tool for different therapeutic strategies. Foreskin (FSK), consi...

    Hussein Fayyad-Kazan, Mohammad Fayyad-Kazan, Bassam Badran, Dominique Bron, Laurence Lagneaux and Mehdi Najar

    Journal of Translational Medicine 2017 15:10

    Published on: 13 January 2017

  7. Research

    Prediction of anti-inflammatory proteins/peptides: an insilico approach

    The current therapy for inflammatory and autoimmune disorders involves the use of nonspecific anti-inflammatory drugs and other immunosuppressant, which are often accompanied with potential side effects. As an...

    Sudheer Gupta, Ashok K. Sharma, Vibhuti Shastri, Midhun K. Madhu and Vineet K. Sharma

    Journal of Translational Medicine 2017 15:7

    Published on: 6 January 2017

  8. Methodology

    Advances in rare cell isolation: an optimization and evaluation study

    Rare nucleated CD45 negative cells in peripheral blood may be malignant such as circulating tumor cells. Untouched isolation thereof by depletion of normal is favored yet still technological challenging. We op...

    Stefan Schreier, Piamsiri Sawaisorn, Rachanee Udomsangpetch and Wannapong Triampo

    Journal of Translational Medicine 2017 15:6

    Published on: 5 January 2017

  9. Research

    Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction

    We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk ...

    Ze-Bang Lin, Hong-Bo Ci, Yan Li, Tian-Pu Cheng, Dong-Hong Liu, Yan-Sheng Wang, Jun Xu, Hao-Xiang Yuan, Hua-Ming Li, Jing Chen, Li Zhou, Zhi-Ping Wang, Xi Zhang, Zhi-Jun Ou and Jing-Song Ou

    Journal of Translational Medicine 2017 15:4

    Published on: 4 January 2017

  10. Research

    Two differentially structured collagen scaffolds for potential urinary bladder augmentation: proof of concept study in a Göttingen minipig model

    The repair of urinary bladder tissue is a necessity for tissue loss due to cancer, trauma, or congenital abnormalities. Use of intestinal tissue is still the gold standard in the urological clinic, which leads...

    Dorothea Leonhäuser, Katja Stollenwerk, Volker Seifarth, Isabella M. Zraik, Michael Vogt, Pramod K. Srinivasan, Rene H. Tolba and Joachim O. Grosse

    Journal of Translational Medicine 2017 15:3

    Published on: 4 January 2017

  11. Research

    Placental mitochondrial DNA and CYP1A1 gene methylation as molecular signatures for tobacco smoke exposure in pregnant women and the relevance for birth weight

    Maternal smoking during pregnancy results in an increased risk of low birth weight through perturbations in the utero-placental exchange. Epigenetics and mitochondrial function in fetal tissues might be molecular...

    Bram G. Janssen, Wilfried Gyselaers, Hyang-Min Byun, Harry A. Roels, Ann Cuypers, Andrea A. Baccarelli and Tim S. Nawrot

    Journal of Translational Medicine 2017 15:5

    Published on: 4 January 2017

  12. Research

    Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response

    Prophylactic and therapeutic vaccines often depend upon a strong activation of the innate immune system to drive a potent adaptive immune response, often mediated by a strong adjuvant. For a number of adjuvant...

    Darin K. Edwards, Edith Jasny, Heesik Yoon, Nigel Horscroft, Brian Schanen, Tanya Geter, Mariola Fotin-Mleczek, Benjamin Petsch and Vaughan Wittman

    Journal of Translational Medicine 2017 15:1

    Published on: 3 January 2017

  13. Research

    Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers—results of a dose escalation trial

    Certain disadvantages of the standard hematopoietic stem and progenitor cell (HSPC) mobilizing agent G-CSF fuel the quest for alternatives. We herein report results of a Phase I dose escalation trial comparing...

    Darja Karpova, Susanne Bräuninger, Eliza Wiercinska, Ariane Krämer, Belinda Stock, Jochen Graff, Hans Martin, Achim Wach, Christophe Escot, Garry Douglas, Barbara Romagnoli, Eric Chevalier, Klaus Dembowski, Leon Hooftman and Halvard Bonig

    Journal of Translational Medicine 2017 15:2

    Published on: 3 January 2017

  14. Commentary

    Association of mitochondrial DNA variants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptoms

    Earlier this year, we described an analysis of mitochondrial DNA (mtDNA) variants in myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) patients and healthy controls. We reported that there was no s...

    Maureen R. Hanson, Zhenglong Gu, Alon Keinan, Kaixiong Ye, Arnaud Germain and Paul Billing-Ross

    Journal of Translational Medicine 2016 14:342

    Published on: 20 December 2016

  15. Research

    Does therapeutic hypothermia during extracorporeal cardiopulmonary resuscitation preserve cardiac function?

    Extracorporeal cardiopulmonary resuscitation (E-CPR) is increasingly used as a rescue method in the management of cardiac arrest and provides the opportunity to rapidly induce therapeutic hypothermia. The surv...

    Harald A. Bergan, Per S. Halvorsen, Helge Skulstad, Erik Fosse and Jan F. Bugge

    Journal of Translational Medicine 2016 14:345

    Published on: 20 December 2016

  16. Research

    Increased T cell breadth and antibody response elicited in prime-boost regimen by viral vector encoded homologous SIV Gag/Env in outbred CD1 mice

    A major obstacle for the development of HIV vaccines is the virus’ worldwide sequence diversity. Nevertheless, the presence of T cell epitopes within conserved regions of the virus’ structural Gag protein and ...

    Anne-Marie Carola Andersson and Peter Johannes Holst

    Journal of Translational Medicine 2016 14:343

    Published on: 20 December 2016

  17. Research

    Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors

    Induced pluripotent stem cells (iPSC) possess an enormous potential as both, scientific and therapeutic tools. Their application in the regenerative medicine provides new treatment opportunities for numerous d...

    Maciej P. Walczak, Anna M. Drozd, Ewelina Stoczynska-Fidelus, Piotr Rieske and Dawid P. Grzela

    Journal of Translational Medicine 2016 14:341

    Published on: 20 December 2016

  18. Research

    LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2

    Mantle cell lymphoma (MCL) is considered an aggressive subtype of non-Hodgkin’s lymphoma with variable treatment responses. There is an urgent need to identify novel markers with prognostic and therapeutic val...

    Xin Wang, Lalit Sehgal, Neeraj Jain, Tamer Khashab, Rohit Mathur and Felipe Samaniego

    Journal of Translational Medicine 2016 14:346

    Published on: 20 December 2016

  19. Research

    Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration

    Study of age related macular degeneration (AMD) has been hampered by lack of human models that represent the complexity of the disease. Here we have developed a human in vitro disease model of AMD to investiga...

    Nady Golestaneh, Yi Chu, Shuk Kei Cheng, Hong Cao, Eugenia Poliakov and Daniel M. Berinstein

    Journal of Translational Medicine 2016 14:344

    Published on: 20 December 2016

  20. Research

    Colonization of xenograft tumors by oncolytic vaccinia virus (VACV) results in enhanced tumor killing due to the involvement of myeloid cells

    The mechanisms by which vaccinia virus (VACV) interacts with the innate immune components are complex and involve different mechanisms. iNOS-mediated NO production by myeloid cells is one of the central antivi...

    Mehmet Okyay Kilinc, Klaas Ehrig, Maysam Pessian, Boris R. Minev and Aladar A. Szalay

    Journal of Translational Medicine 2016 14:340

    Published on: 20 December 2016

  21. Research

    FGFR1 and NTRK3 actionable alterations in “Wild-Type” gastrointestinal stromal tumors

    About 10–15% of adult, and most pediatric, gastrointestinal stromal tumors (GIST) lack mutations in KIT, PDGFRA, SDHx, or RAS pathway components (KRAS, BRAF, NF1). The identification of additional mutated gene...

    Eileen Shi, Juliann Chmielecki, Chih-Min Tang, Kai Wang, Michael C. Heinrich, Guhyun Kang, Christopher L. Corless, David Hong, Katherine E. Fero, James D. Murphy, Paul T. Fanta, Siraj M. Ali, Martina De Siena, Adam M. Burgoyne, Sujana Movva, Lisa Madlensky…

    Journal of Translational Medicine 2016 14:339

    Published on: 14 December 2016

  22. Research

    Hyperbranched polyglycerol is superior to glucose for long-term preservation of peritoneal membrane in a rat model of chronic peritoneal dialysis

    Replacing glucose with a better biocompatible osmotic agent in peritoneal dialysis (PD) solutions is needed in PD clinic. We previously demonstrated the potential of hyperbranched polyglycerol (HPG) as a repla...

    Caigan Du, Asher A. Mendelson, Qiunong Guan, Ghida Dairi, Irina Chafeeva, Gerald da Roza and Jayachandran N. Kizhakkedathu

    Journal of Translational Medicine 2016 14:338

    Published on: 13 December 2016

  23. Research

    PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment

    The robust desmoplasia associated with head and neck squamous cell carcinoma (HNSCC) suggests that the tumor microenvironment may be an important component in the pathophysiology of this cancer. Moreover, the ...

    Tammara L. Watts, Ruwen Cui, Peter Szaniszlo, Vicente A. Resto, Don W. Powell and Irina V. Pinchuk

    Journal of Translational Medicine 2016 14:337

    Published on: 8 December 2016

  24. Research

    Thyroid hormones associate with risk of incident chronic kidney disease and rapid decline in renal function: a prospective investigation

    Thyroid hormones have been associated with renal dysfunction in cross-sectional studies. However, prospective studies exploring the effect of thyroid hormones on renal function decline were sparse and got cont...

    Xiaolin Huang, Lin Ding, Kui Peng, Lin Lin, Tiange Wang, Zhiyun Zhao, Yu Xu, Jieli Lu, Yuhong Chen, Weiqing Wang, Yufang Bi, Guang Ning and Min Xu

    Journal of Translational Medicine 2016 14:336

    Published on: 3 December 2016

Previous Page Page 1 of 117 Next Page