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  1. The progression of diabetic cardiomyopathy (DCM) is noticeably influenced by mitochondrial dysfunction. Variants of caveolin 3 (CAV3) play important roles in cardiovascular diseases. However, the potential rol...

    Authors: Ping Guo, Shuiqing Hu, Xiaohui Liu, Miaomiao He, Jie Li, Tingqiong Ma, Man Huang, Qin Fang and Yan Wang
    Citation: Journal of Translational Medicine 2024 22:390
  2. Myxoid liposarcoma (MLS) displays a distinctive tumor microenvironment and is characterized by the FUS::DDIT3 fusion oncogene, however, the precise functional contributions of these two elements remain enigmatic ...

    Authors: Parmida Ranji, Emma Jonasson, Lisa Andersson, Stefan Filges, Manuel Luna Santamaría, Christoffer Vannas, Soheila Dolatabadi, Anna Gustafsson, Ola Myklebost, Joakim Håkansson, Henrik Fagman, Göran Landberg, Pierre Åman and Anders Ståhlberg
    Citation: Journal of Translational Medicine 2024 22:389
  3. The kallikrein-kinin system is a key regulatory cascade involved in blood pressure maintenance, hemostasis, inflammation and renal function. Currently, approved drugs remain limited to the rare disease heredit...

    Authors: Petra Wisniewski, Tanja Gangnus and Bjoern B. Burckhardt
    Citation: Journal of Translational Medicine 2024 22:388
  4. Integrating quantitative trait loci (QTL) data related to molecular phenotypes with genome-wide association study (GWAS) data is an important post-GWAS strategic approach employed to identify disease-associate...

    Authors: Lingxue Luo, Tao Pang, Haohao Zheng, Chao Liufu and Suhua Chang
    Citation: Journal of Translational Medicine 2024 22:387
  5. Sequencing the mitochondrial genome has been increasingly important for the investigation of primary mitochondrial diseases (PMD) and mitochondrial genetics. To overcome the limitations originating from PCR-ba...

    Authors: Dong Liang, Lin Zhu, Yuqing Zhu, Mingtao Huang, Ying Lin, Hang Li, Ping Hu, Jun Zhang, Bin Shen and Zhengfeng Xu
    Citation: Journal of Translational Medicine 2024 22:386
  6. Chimeric antigen receptor (CAR) T-cells have demonstrated significant efficacy in targeting hematological malignancies, and their use continues to expand. Despite substantial efforts spent on the optimization ...

    Authors: Michaela Prochazkova, Alexandra Dreyzin, Lipei Shao, Pam Garces, Yihua Cai, Rongye Shi, Alejandra Pelayo, Yong Soo Kim, Victoria Pham, Sue Ellen Frodigh, Shannon Fenton, Catherine Karangwa, Yan Su, Kathryn Martin, Nan Zhang, Steven L. Highfill…
    Citation: Journal of Translational Medicine 2024 22:384
  7. Loss of AZGP1 expression is a biomarker associated with progression to castration resistance, development of metastasis, and poor disease-specific survival in prostate cancer. However, high expression of AZGP1...

    Authors: Ru M. Wen, Zhengyuan Qiu, G. Edward W. Marti, Eric E. Peterson, Fernando Jose Garcia Marques, Abel Bermudez, Yi Wei, Rosalie Nolley, Nathan Lam, Alex LaPat Polasko, Chun-Lung Chiu, Dalin Zhang, Sanghee Cho, Grigorios Marios Karageorgos, Elizabeth McDonough, Chrystal Chadwick…
    Citation: Journal of Translational Medicine 2024 22:383
  8. Tumors are highly complex and heterogenous ecosystems where malignant cells interact with healthy cells and the surrounding extracellular matrix (ECM). Solid tumors contain large ECM deposits that can constitu...

    Authors: Rowie Borst, Linde Meyaard and M. Ines Pascoal Ramos
    Citation: Journal of Translational Medicine 2024 22:382
  9. Gastric cancer (GC) is a common and aggressive type of cancer worldwide. Despite recent advancements in its treatment, the prognosis for patients with GC remains poor. Understanding the mechanisms of cell deat...

    Authors: Yimeng Ma, Jingjing Jin, Zixuan Xue, Jungang Zhao, Weiyang Cai and Wanli Zhang
    Citation: Journal of Translational Medicine 2024 22:381
  10. Proliferative nodular formation represents a characteristic pathological feature of benign prostatic hyperplasia (BPH) and serves as the primary cause for prostate volume enlargement and consequent lower urina...

    Authors: Xiawei Fei, Jican Liu, Junyan Xu, Hongyan Jing, Zhonglin Cai, Jiasheng Yan, Zhenqi Wu, Huifeng Li, Zhong Wang and Yanting Shen
    Citation: Journal of Translational Medicine 2024 22:380
  11. TAS-102 (Lonsurf®) is an oral fluoropyrimidine consisting of a combination of trifluridine (a thymidine analog) and tipiracil (a thymidine phosphorylation inhibitor). The drug is effective in metastatic colorecta...

    Authors: Alessandro Ottaiano, Mariachiara Santorsola, Monica Ianniello, Anna Ceccarelli, Marika Casillo, Francesco Sabbatino, Nadia Petrillo, Marco Cascella, Francesco Caraglia, Carmine Picone, Francesco Perri, Roberto Sirica, Silvia Zappavigna, Guglielmo Nasti, Giovanni Savarese and Michele Caraglia
    Citation: Journal of Translational Medicine 2024 22:379
  12. Bacteria-based cancer therapy have demonstrated innovative strategies to combat tumors. Recent studies have focused on gram-negative bacterial outer membrane vesicles (OMVs) as a novel cancer immunotherapy str...

    Authors: Suyang Wang, Chao-Cheng Chen, Ming-Hung Hu, Michelle Cheng, Hsin-Fang Tu, Ya-Chea Tsai, Jr-Ming Yang, T. C. Wu, Chuan-Hsiang Huang and Chien-Fu Hung
    Citation: Journal of Translational Medicine 2024 22:378
  13. In individuals diagnosed with obstructive sleep apnea syndrome (OSAS), variations in craniofacial structure have been inconsistently documented, showing differing degrees of alteration between obese and nonobe...

    Authors: Eugenio Garofalo, Giuseppe Neri, Lucilla Maria Perri, Nicola Lombardo, Giovanna Piazzetta, Alessandro Antonelli, Eugenio Biamonte, Vincenzo Bosco, Caterina Battaglia, Corrado Pelaia, Francesco Manti, Annalisa Pitino, Giovanni Tripepi, Andrea Bruni, Michele Morelli, Amerigo Giudice…
    Citation: Journal of Translational Medicine 2024 22:377
  14. Maladaptive cardiac hypertrophy contributes to the development of heart failure (HF). The oxidoreductase Selenoprotein T (SELENOT) emerged as a key regulator during rat cardiogenesis and acute cardiac protecti...

    Authors: Anna De Bartolo, Teresa Pasqua, Naomi Romeo, Vittoria Rago, Ida Perrotta, Francesca Giordano, Maria Concetta Granieri, Alessandro Marrone, Rosa Mazza, Maria Carmela Cerra, Benjamin Lefranc, Jérôme Leprince, Youssef Anouar, Tommaso Angelone and Carmine Rocca
    Citation: Journal of Translational Medicine 2024 22:375
  15. Inflammatory breast cancer (IBC) is the most pro-metastatic form of BC. Better understanding of its enigmatic pathophysiology is crucial. We report here the largest whole-exome sequencing (WES) study of clinic...

    Authors: François Bertucci, Florence Lerebours, Michele Ceccarelli, Arnaud Guille, Najeeb Syed, Pascal Finetti, José Adélaïde, Steven Van Laere, Anthony Goncalves, Patrice Viens, Daniel Birnbaum, Emilie Mamessier, Céline Callens and Davide Bedognetti
    Citation: Journal of Translational Medicine 2024 22:374
  16. Platelets not only participate in thrombosis and hemostasis but also interact with tumor cells and protect them from mechanical damage caused by hemodynamic shear stress and natural killer cell lysis, thereby ...

    Authors: Jie Xue, Jianzhao Deng, Hongwei Qin, Songxia Yan, Zhen Zhao, Lifeng Qin, Jiao Liu and Haiyan Wang
    Citation: Journal of Translational Medicine 2024 22:371
  17. JAK-STAT signalling pathway inhibitors have emerged as promising therapeutic agents for the treatment of hair loss. Among different JAK isoforms, JAK3 has become an ideal target for drug discovery because it o...

    Authors: Md Mehedi Hossain, Arfan Khalid, Zaheen Akhter, Sabra Parveen, Mir Owais Ayaz, Aadil Qadir Bhat, Neetu Badesra, Farheen Showket, Mohmmad Saleem Dar, Farhan Ahmed, Sumit Dhiman, Mukesh Kumar, Umed Singh, Razak Hussain, Pankaj Keshari, Ghulam Mustafa…
    Citation: Journal of Translational Medicine 2024 22:370
  18. Patients with inflammatory bowel disease (IBD), dysbiosis, and immunosuppression who receive fecal microbiota transplantation (FMT) from healthy donors are at an increased risk of developing bacteremia. This s...

    Authors: Hailan Zhao, Youlian Zhou, Jing Xu, Yong Zhang, Hong Wang, Chong Zhao, Hongli Huang, Jing Yang, Chen Huang, Yingfei Li, Lisheng Wang and Yuqiang Nie
    Citation: Journal of Translational Medicine 2024 22:369
  19. In this study, we investigated CD70 as a promising target for renal cell carcinoma (RCC) therapy and developed a potent chimeric antigen receptor T (CAR-T) cells for potential clinical testing. CD70, found to ...

    Authors: Qinghui Xiong, Haiying Wang, Qiushuang Shen, Yan Wang, Xiujie Yuan, Guangyao Lin and Pengfei Jiang
    Citation: Journal of Translational Medicine 2024 22:368
  20. Ovarian cancer (OC) is characterized by its rapid growth and spread which, accompanied by a low 5-year survival rate, necessitates the development of improved treatments. In ovarian cancer, the selective overe...

    Authors: Jing Guo, Xiaozhu Zeng, Yongjie Zhu, Dong Yang and Xudong Zhao
    Citation: Journal of Translational Medicine 2024 22:367
  21. Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic risk, but the majority of EOPC patients still substantial opportunity to be early-detected thus suffering an u...

    Authors: Yifei Cheng, Lang Wu, Junyi Xin, Shuai Ben, Silu Chen, Huiqin Li, Lingyan Zhao, Meilin Wang, Gong Cheng and Mulong Du
    Citation: Journal of Translational Medicine 2024 22:366
  22. Molecular subtyping is expected to enable precise treatment. However, reliable subtyping strategies for clinical application remains defective and controversial. Given the significance of tumor immune dysfunct...

    Authors: Kun Zheng, Youlong Hai, Hongqi Chen, Yukun Zhang, Xiaoyong Hu and Kai Ni
    Citation: Journal of Translational Medicine 2024 22:365
  23. Polycystic ovary syndrome (PCOS) is an endocrinological and metabolic disorder that can lead to female infertility. Lipid metabolomics and proteomics are the new disciplines in systems biology aimed to discove...

    Authors: Yu Qian, Yun Tong, Yaqiong Zeng, Jingyu Huang, Kailu Liu, Ying Xie, Juan Chen, Mengya Gao, Li Liu, Juan Zhao, Yanli Hong and Xiaowei Nie
    Citation: Journal of Translational Medicine 2024 22:364
  24. Interleukin-33 (IL-33), an emerging cytokine within the IL-1 family, assumes a pivotal function in the control of obesity. However, the specific mechanism of its regulation of obesity formation remains unclear...

    Authors: Danning Xu, Siqi Zhuang, Hongzhi Chen, Mengjie Jiang, Ping Jiang, Qian Wang, Xuemei Wang, Ruohong Chen, Haoneng Tang and Lingli Tang
    Citation: Journal of Translational Medicine 2024 22:363
  25. HER3 (ErbB3), a member of the human epidermal growth factor receptor family, is frequently overexpressed in various cancers. Multiple HER3-targeting antibodies and antibody–drug conjugates (ADCs) were develope...

    Authors: Xi Li, Jun Yao, Chen Qu, Lan Luo, Bing Li, Yu Zhang, Zhongyuan Zhu, Yang Qiu and Haiqing Hua
    Citation: Journal of Translational Medicine 2024 22:362
  26. Most colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse pathological morphologies and to explore the risk factors for colorect...

    Authors: Xiaojuan Li, Mengting Hu, Zhangjun Wang, Mei Liu and Ying Chen
    Citation: Journal of Translational Medicine 2024 22:361
  27. Preeclampsia is a pregnancy-specific disease leading to maternal and perinatal morbidity. Hypertension and inflammation are the main characteristics of preeclampsia. Many factors can lead to hypertension and i...

    Authors: Xianxian Liu, Xiaoming Zeng, Xing Li, Siming Xin, Feng Zhang, Faying Liu, Yang Zeng, Jilin Wu, Yang Zou and Xinwei Xiong
    Citation: Journal of Translational Medicine 2024 22:360
  28. Myelodysplastic neoplasms (MDS) are myeloid neoplasms characterized by disordered differentiation of hematopoietic stem cells and a predisposition to acute myeloid leukemia (AML). The underline pathogenesis re...

    Authors: Xiangzong Zeng, Yichen Wang, Min Dai, Wei Li, Qingtian Huang, Lingsha Qin, Yuquan Li, Yanwen Yan, Xiangjun Xue, Fang Yi, Wenhao Li, Langyu He, Qifa Liu and Ling Qi
    Citation: Journal of Translational Medicine 2024 22:359
  29. Diabetic macular edema (DME) is a leading cause of vision loss in patients with diabetes. This study aimed to develop and evaluate an OCT-omics prediction model for assessing anti-vascular endothelial growth f...

    Authors: Zhishang Meng, Yanzhu Chen, Haoyu Li, Yue Zhang, Xiaoxi Yao, Yongan Meng, Wen Shi, Youling Liang, Yuqian Hu, Dan Liu, Manyun Xie, Bin Yan and Jing Luo
    Citation: Journal of Translational Medicine 2024 22:358
  30. Authors: Giuseppina Caiazzo, Rosa Redenta De Simone, Emanuele Monda, Ferdinando Barretta, Fabiana Uomo, Cristina Mazzaccara, Matteo Megna, Limongelli Giuseppe and Giulia Frisso
    Citation: Journal of Translational Medicine 2024 22:357
  31. Machine learning (ML) methods are increasingly becoming crucial in genome-wide association studies for identifying key genetic variants or SNPs that statistical methods might overlook. Statistical methods pred...

    Authors: Z. Alireza, M. Maleeha, M. Kaikkonen and V. Fortino
    Citation: Journal of Translational Medicine 2024 22:356
  32. Glaucoma is a leading cause of worldwide irreversible blindness. Considerable uncertainty remains regarding the association between a variety of phenotypes and the genetic risk of glaucoma, as well as the impa...

    Authors: Jae-Seung Yun, Sang-Hyuk Jung, Su-Nam Lee, Seung Min Jung, Hong-Hee Won, Dokyoon Kim and Jin A. Choi
    Citation: Journal of Translational Medicine 2024 22:355
  33. Recent studies have increasingly revealed the connection between metabolic reprogramming and tumor progression. However, the specific impact of metabolic reprogramming on inter-patient heterogeneity and progno...

    Authors: Xinti Sun, Minyu Nong, Fei Meng, Xiaojuan Sun, Lihe Jiang, Zihao Li and Peng Zhang
    Citation: Journal of Translational Medicine 2024 22:353
  34. Quinic acid (QA) and its derivatives have good lipid-lowering and hepatoprotective functions, but their role in atherosclerosis remains unknown. This study attempted to investigate the mechanism of QA on ather...

    Authors: Qiao Jin, Chiyuan Zhang, Ran Chen, Luping Jiang, Hongli Li, Pengcui Wu and Liang Li
    Citation: Journal of Translational Medicine 2024 22:352
  35. Cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein, is vital in preserving cartilage integrity. Further, its overexpression is associated with the aggressiveness of several types ...

    Authors: Gilar Gorji-Bahri, B. Madhu Krishna, Catharina Hagerling, Akira Orimo, Karin Jirström, Konstantinos S. Papadakos and Anna M. Blom
    Citation: Journal of Translational Medicine 2024 22:351
  36. Olfactory dysfunction occurs frequently in Parkinson’s disease (PD). In this study, we aimed to explore the potential biomarkers and underlying molecular pathways of nicotine for the treatment of olfactory dys...

    Authors: Qinglong Guo, Yi Wang, Liangchen Yu, Liao Guan, Xuefei Ji, Xiaohui Li, Gang Pang, Zhenhua Ren, Lei Ye and Hongwei Cheng
    Citation: Journal of Translational Medicine 2024 22:350
  37. Chimeric antigen receptor T (CAR-T) cell therapy, as an emerging anti-tumor treatment, has garnered extensive attention in the study of targeted therapy of multiple tumor-associated antigens in hepatocellular ...

    Authors: Keming Lin, Baijin Xia, Xuemei Wang, Xin He, Mo Zhou, Yingtong Lin, Yidan Qiao, Rong Li, Qier Chen, Yuzhuang Li, Jinzhu Feng, Tao Chen, Cancan Chen, Xinyu Li, Hui Zhang, Lijuan Lu…
    Citation: Journal of Translational Medicine 2024 22:349
  38. THOC7-AS1 and FSTL1 expression are frequently upregulated in cutaneous squamous cell carcinoma (cSCC). However, their molecular biological mechanisms remain elusive and their potential as therapeutic targets n...

    Authors: Site Yu, Xu Cui, Situo Zhou, Yun Li, Wenjie Feng, Xiangjun Zhang, Yuhui Zhong and Pihong Zhang
    Citation: Journal of Translational Medicine 2024 22:347
  39. Acute pancreatitis (AP) is a clinically common acute abdominal disease, whose pathogenesis remains unclear. The severe patients usually have multiple complications and lack specific drugs, leading to a high mo...

    Authors: Kaige Yang, Rongli Xie, Guohui Xiao, Zhifeng Zhao, Min Ding, Tingyu Lin, Yiu Sing Tsang, Ying Chen, Dan Xu and Jian Fei
    Citation: Journal of Translational Medicine 2024 22:346
  40. Hearing loss has been shown to be a risk factor for psychiatric disorders. In addition, long-term hearing loss is associated with increased hospitalization and mortality rates; however, the increased risk and ...

    Authors: Qun-Yi Nian, Chun-An Cheng, Li-Hsiang Cheng, Yuan-Yung Lin, Chin-Hung Wang, Wu-Chien Chien, Yueng-Hsiang Chu, Cheng-Ping Shih, Chao-Yin Kuo, Hsin-Chien Chen, Jih-Chin Lee, Chi-Hsiang Chung, Wei-Chuan Shangkuan and Hung-Che Lin
    Citation: Journal of Translational Medicine 2024 22:345
  41. Tumors are mostly characterized by genetic instability, as result of mutations in surveillance mechanisms, such as DNA damage checkpoint, DNA repair machinery and mitotic checkpoint. Defect in one or more of t...

    Authors: Concetta Ragone, Beatrice Cavalluzzo, Angela Mauriello, Maria Tagliamonte and Luigi Buonaguro
    Citation: Journal of Translational Medicine 2024 22:344
  42. Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID. Howeve...

    Authors: Joan Carles Domingo, Federica Battistini, Begoña Cordobilla, Maria Cleofé Zaragozá, Ramón Sanmartin-Sentañes, Jose Alegre-Martin, Trinitat Cambras and Jesus Castro-Marrero
    Citation: Journal of Translational Medicine 2024 22:343
  43. The COVID-19 pandemic caused societal disruption in the United States and most of the world, affecting many aspects of life, including healthcare and health-related behaviors such as diet, food security, and p...

    Authors: Giovanna Muscogiuri, Lindsay Kohler, Oscar Parra, Lisa Soltani, Douglas Spegman, Dawn Coletta and Lawrence J. Mandarino
    Citation: Journal of Translational Medicine 2024 22:342
  44. One of the most effective strategies to fight viruses and handle health diseases is vaccination. Recent studies and current applications are moving on antigen, DNA and RNA-based vaccines to overcome the limita...

    Authors: Domenico Riccardi, Lucia Baldino and Ernesto Reverchon
    Citation: Journal of Translational Medicine 2024 22:339

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