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  1. Lower-grade glioma (LGG) is a highly heterogeneous disease that presents challenges in accurately predicting patient prognosis. Mitochondria play a central role in the energy metabolism of eukaryotic cells and...

    Authors: Hu Qin, Aimitaji Abulaiti, Aierpati Maimaiti, Zulihuma Abulaiti, Guofeng Fan, Yirizhati Aili, Wenyu Ji, Zengliang Wang and Yongxin Wang
    Citation: Journal of Translational Medicine 2023 21:588
  2. Chronic obstructive pulmonary disease (COPD) patients often exhibit gastrointestinal symptoms, A potential association between COPD and Colorectal Cancer (CRC) has been indicated, warranting further examination.

    Authors: Youtao Zhou, Zikai Lin, Shuojia Xie, Yuan Gao, Haobin Zhou, Fengzhen Chen, Yuewu Fu, Cuiyan Yang and Chuanfeng Ke
    Citation: Journal of Translational Medicine 2023 21:587
  3. As the most lethal gynecologic cancer, ovarian cancer (OV) holds the potential of being immunotherapy-responsive. However, only modest therapeutic effects have been achieved by immunotherapies such as immune c...

    Authors: Dong Yang, Mei-Han Duan, Qiu-Er Yuan, Zhi-Ling Li, Chuang-Hua Luo, Lan-Yue Cui, Li-Chao Li, Ying Xiao, Xian-Ying Zhu, Hai-Liang Zhang, Gong-Kan Feng, Guo-Chen Liu, Rong Deng, Jun-Dong Li and Xiao-Feng Zhu
    Citation: Journal of Translational Medicine 2023 21:586
  4. Lung cancer is the leading cause of cancer deaths worldwide. Despite never smokers comprising between 10 and 25% of all cases, lung cancer in never smokers (LCNS) is relatively under characterized from an etio...

    Authors: Peiyao Wang, Sophie Sun, Stephen Lam and William W. Lockwood
    Citation: Journal of Translational Medicine 2023 21:585
  5. Disasters and accidents have occurred with increasing frequency in recent years. Primary disasters have the potential to result in mass casualty events involving crush syndrome (CS) and other serious injuries....

    Authors: Daisuke Usuda, Shintaro Shimozawa, Hiroki Takami, Yoshinobu Kako, Taigo Sakamoto, Junya Shimazaki, Junichi Inoue, Shinichi Nakayama, Yuichi Koido and Jiro Oba
    Citation: Journal of Translational Medicine 2023 21:584
  6. Currently, women around the world are still suffering from various female common diseases with the high incidence, such as ovarian cancer, uterine fibroids and preeclampsia (PE), and some diseases are even wit...

    Authors: Qiang Xu, Mukun Yao and Chao Tang
    Citation: Journal of Translational Medicine 2023 21:583
  7. Over the last five decades, breast density has been associated with increased risk of developing breast cancer. Mammographically dense breasts are considered those belonging to the heterogeneously dense breast...

    Authors: Sofia M. Tarchi, Monica Pernia Marin, Md. Murad Hossain and Mary Salvatore
    Citation: Journal of Translational Medicine 2023 21:582
  8. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are seed cells that can be used for alternative treatment of myocardial damage. However, their immaturity limits their clinical applicatio...

    Authors: Huiwen Liu, Li Wang, Hao Xu, Bin Tan, Qin Yi, Hongrong Deng, Yunxia Chen, Bolin He, Jie Tian and Jing Zhu
    Citation: Journal of Translational Medicine 2023 21:581
  9. To gain deeper insights into the microenvironment of breast cancer, we utilized GeoMx Digital Spatial Profiling (DSP) technology to analyze transcripts from 107 regions of interest in 65 untreated breast cance...

    Authors: Guohong Liu, Liping Wang, Lili Ji, Dan He, Lihua Zeng, Guangzheng Zhuo, Qian Zhang, Dujuan Wang and Yunbao Pan
    Citation: Journal of Translational Medicine 2023 21:580
  10. Janus kinase 1 (JAK1) plays a critical role in most cytokine-mediated inflammatory, autoimmune responses and various cancers via the JAK/STAT signaling pathway. Inhibition of JAK1 is therefore an attractive th...

    Authors: Zixiao Wang, Lili Sun, Yu Xu, Peida Liang, Kaiyan Xu and Jing Huang
    Citation: Journal of Translational Medicine 2023 21:579
  11. Pancreatic ductal adenocarcinoma (PDAC) is expected to soon surpass colorectal cancer as a leading cause of cancer mortality in both males and females in the US, only lagging behind lung cancer. The lethality ...

    Authors: Nuno Bastos, Stéphanie A. Castaldo, Bárbara Adem, José C. Machado, Carlos A. Melo and Sonia A. Melo
    Citation: Journal of Translational Medicine 2023 21:578
  12. With metabolic alterations of the tumor microenvironment (TME) contributing to cancer progression, metastatic spread and response to targeted therapies, non-invasive and repetitive imaging of tumor metabolism ...

    Authors: Emily Hoffmann, Daniel Schache, Carsten Höltke, Jens Soltwisch, Stephan Niland, Tobias Krähling, Klaus Bergander, Martin Grewer, Christiane Geyer, Linda Groeneweg, Johannes A. Eble, Thomas Vogl, Johannes Roth, Walter Heindel, Bastian Maus, Anne Helfen…
    Citation: Journal of Translational Medicine 2023 21:577
  13. Tumor hypoxia is associated with resistance to radiotherapy and chemotherapy. In head and neck squamous cell carcinoma (HNSCC), nimorazole, an oxygen mimic, combined with radiotherapy (RT) enabled to improve l...

    Authors: Lydia Koi, Verena Bitto, Corina Weise, Lisa Möbius, Annett Linge, Steffen Löck, Ala Yaromina, María José Besso, Chiara Valentini, Manuel Pfeifer, Jens Overgaard, Daniel Zips, Ina Kurth, Mechthild Krause and Michael Baumann
    Citation: Journal of Translational Medicine 2023 21:576
  14. Benign prostatic hyperplasia (BPH) is a common disease in elderly men, mainly resulted from an imbalance between cell proliferation and death. Glutathione peroxidase 3 (GPX3) was one of the differentially expr...

    Authors: Yan Li, Yongying Zhou, Daoquan Liu, Zhen Wang, Jizhang Qiu, Junchao Zhang, Ping Chen, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E. DiSanto and Xinhua Zhang
    Citation: Journal of Translational Medicine 2023 21:575
  15. This study investigated the correlation between the expression of DARS2 and metabolic parameters of 18F-FDG PET/CT, and explored the potential mechanisms of DARS2 affecting the proliferation and glycolysis of lun...

    Authors: Xu-Sheng Liu, Ling-Ling Yuan, Yan Gao, Xing Ming, Yao-Hua Zhang, Yu Zhang, Zi-Yue Liu, Yi Yang and Zhi-Jun Pei
    Citation: Journal of Translational Medicine 2023 21:574
  16. Ankylosing spondylitis (AS) is an autoimmune disease with a genetic correlation and is characterized by inflammation in the axial skeleton and sacroiliac joints. Many AS patients also have inflammatory bowel d...

    Authors: Xinzhe Feng, Shanbang Zhu, Junjie Qiao, Zhou Ji, Bole Zhou and Weidong Xu
    Citation: Journal of Translational Medicine 2023 21:573
  17. Immunotoxins are antibody-toxin conjugates that bind to surface antigens and exert effective cytotoxic activity after internalization into tumor cells. Immunotoxins exhibit effective cytotoxicity and have been...

    Authors: Xiaoyu Liu, Qingqing Tan, Jiaqi Wen, Xufei Wang, Gang Yang, Yuxiao Li, Ming Lu, Wei Ye, Anfeng Si, Sujuan Ma, Tong Ding, Luan Sun, Fang Liu, Mei Zhang, Tao Jiang and Wei Gao
    Citation: Journal of Translational Medicine 2023 21:572
  18. Authors: Gunjan Dagar, Ashna Gupta, Tariq Masoodi, Sabah Nisar, Maysaloun Merhi, Sheema Hashem, Ravi Chauhan, Manisha Dagar, Sameer Mirza, Puneet Bagga, Rakesh Kumar, Ammira S. Al-Shabeeb Akil, Muzafar A. Macha, Mohammad Haris, Shahab Uddin, Mayank Singh…
    Citation: Journal of Translational Medicine 2023 21:571

    The original article was published in Journal of Translational Medicine 2023 21:449

  19. Breast cancer is the most common cancer affecting women across the world. Tumor endothelial cells (TECs) and malignant cells are the major constituents of the tumor microenvironment (TME), but their origin and...

    Authors: Youxue Zhang, Fang Zhen, Yue Sun, Bing Han, Hongyi Wang, Yuhang Zhang, Huaixi Zhang and Jing Hu
    Citation: Journal of Translational Medicine 2023 21:570
  20. Photoreceptor degeneration underpinned by oxidative stress-mediated mitochondrial dysfunction and cell death leads to progressive and irreversible vision impairment. Drug treatments that protect against photor...

    Authors: Daijin Li, Jing Xu, Jie Chang, Yujue Wang, Xiaoye Du, Hanhan Wu, Jingang Cui, Peiwei Wang, Teng Zhang and Yu Chen
    Citation: Journal of Translational Medicine 2023 21:569
  21. Non-alcoholic Fatty Liver Disease (NAFLD), now better known as Metabolic (Dysfunction)-Associated Fatty Liver Disease (MAFLD) and its progression to Nonalcoholic Steatohepatitis (NASH), more recently referred ...

    Authors: Paolo Convertini, Anna Santarsiero, Simona Todisco, Michele Gilio, Donatella Palazzo, Ilaria Pappalardo, Dominga Iacobazzi, Maria Frontuto and Vittoria Infantino
    Citation: Journal of Translational Medicine 2023 21:568
  22. The nucleotide-binding oligomeric domain (NOD)-like receptor protein 3 (NLRP3) inflammasome is believed to be a key mediator of neuroinflammation and subsequent secondary brain injury induced by ischemic strok...

    Authors: Yuxin Chen, Xiaohuan Li, Qian Xiong, Yehong Du, Man Luo, Lilin Yi, Yayan Pang, Xiuyu Shi, Yu Tian Wang and Zhifang Dong
    Citation: Journal of Translational Medicine 2023 21:567
  23. Long-chain acyl-carnitines (ACs) are potential arrhythmogenic metabolites. Their role in atrial fibrillation (AF) remains incompletely understood. Using a systems medicine approach, we assessed the contributio...

    Authors: Julia Krause, Alexander Nickel, Alexandra Madsen, Hamish M. Aitken-Buck, A. M. Stella Stoter, Jessica Schrapers, Francisco Ojeda, Kira Geiger, Melanie Kern, Michael Kohlhaas, Edoardo Bertero, Patrick Hofmockel, Florian Hübner, Ines Assum, Matthias Heinig, Christian Müller…
    Citation: Journal of Translational Medicine 2023 21:566
  24. Intracerebral hemorrhage (ICH) is a condition associated with high morbidity and mortality, and glia-mediated inflammation is a major contributor to neurological deficits. However, there is currently no proven...

    Authors: Wei-Shen Su, Chun-Hu Wu, Wen-Shin Song, Szu-Fu Chen and Feng-Yi Yang
    Citation: Journal of Translational Medicine 2023 21:565
  25. Myasthenia gravis (MG) is the most prevalent autoimmune disorder affecting the neuromuscular junction. A rapid deterioration in respiratory muscle can lead to a myasthenic crisis (MC), which represents a life-...

    Authors: Huahua Zhong, Xiao Huan, Rui Zhao, Manqiqige Su, Chong Yan, Jie Song, Jianying Xi, Chongbo Zhao, Feifei Luo and Sushan Luo
    Citation: Journal of Translational Medicine 2023 21:564
  26. Brachial plexus root avulsion (BPRA), a disabling peripheral nerve injury, induces substantial motoneuron death, motor axon degeneration and denervation of biceps muscles, leading to the loss of upper limb mot...

    Authors: Lin Wu, Shuangxi Chen, Bing He, Guijuan Zhou, Yan Xu, Guanghua Zhu, Juan Xie, Limin Deng, Xuanwei Wen, Sijing Li and Zijian Xiao
    Citation: Journal of Translational Medicine 2023 21:563
  27. Alpha-melanocyte stimulating hormone (α-MSH) and its receptor, melanocortin 1 receptor (MC1R), have been proposed as potential target for anti-cancer strategies in melanoma research, due to their tissue specif...

    Authors: Luigi Dall’Olmo, Nicole Papa, Nicoletta Concetta Surdo, Ilaria Marigo and Simone Mocellin
    Citation: Journal of Translational Medicine 2023 21:562
  28. Rheumatoid arthritis (RA) is an autoimmune disease that exhibits a high degree of heterogeneity, marked by unpredictable disease flares and significant variations in the response to available treatments. The l...

    Authors: Qi Wang, Qi-Chao Gao, Qi-Chuan Wang, Li Wu, Qi Yu and Pei-Feng He
    Citation: Journal of Translational Medicine 2023 21:561
  29. Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other. There is currently no sp...

    Authors: Álvaro González-Domínguez, Thalía Belmonte, Jesús Domínguez-Riscart, Pablo Ruiz-Ocaña, Inés Muela-Zarzuela, Ana Saez-Benito, Raúl Montañez-Martínez, Rosa M. Mateos and Alfonso M. Lechuga-Sancho
    Citation: Journal of Translational Medicine 2023 21:559
  30. Tumor invasiveness reflects numerous biological changes, including tumorigenesis, progression, and metastasis. To decipher the role of transcriptional regulators (TR) involved in tumor invasiveness, we perform...

    Authors: Mahesh Jethalia, Siddhi P. Jani, Michele Ceccarelli and Raghvendra Mall
    Citation: Journal of Translational Medicine 2023 21:558
  31. Limited published data suggests that absence of uplifts (minor pleasant events) is associated with clinical worsening in patients with chronic fatigue syndrome (CFS). The current study aimed to assess the rela...

    Authors: Fred Friedberg, Jenna L. Adamowicz, Patricia Bruckenthal, Maria Milazzo, Sameera Ramjan, Xiaoyue Zhang and Jie Yang
    Citation: Journal of Translational Medicine 2023 21:557
  32. Breast cancer (BC) as one of the most common causes of human deaths among women, is always considered one of the global health challenges. Despite various advances in diagnostic and therapeutic methods, a sign...

    Authors: Amirhosein Maharati and Meysam Moghbeli
    Citation: Journal of Translational Medicine 2023 21:556
  33. Ocular neovascularization is a leading cause of blindness and visual impairment. While intravitreal anti-VEGF agents can be effective, they do have several drawbacks, such as endophthalmitis and drug resistanc...

    Authors: Wen Bai, Jun-Song Ren, Min Xia, Ya Zhao, Jing-Juan Ding, Xi Chen and Qin Jiang
    Citation: Journal of Translational Medicine 2023 21:555
  34. Intestinal fibrosis is a common and severe complication of inflammatory bowel disease without clear pathogenesis. Abnormal expression of host genes and metabolic perturbations might associate with the onset of...

    Authors: Jinzhen Wu, Zhenyi Tian, Xiaoduan Zhuang, Yiru Chen, Tingting Fan, Jiayun Li and Xinying Wang
    Citation: Journal of Translational Medicine 2023 21:554
  35. Triple-negative breast cancer (TNBC) is one of the most aggressive human cancers and has poor prognosis. Approximately 80% of TNBC cases belong to the molecular basal-like subtype, which can be exploited thera...

    Authors: Jie Lei, Yujia Pan, Rui Gao, Bin He, Zifeng Wang, Xinxing Lei, Zijian Zhang, Na Yang and Min Yan
    Citation: Journal of Translational Medicine 2023 21:553
  36. The prognosis of esophageal adenocarcinoma (EAC) and gastric adenocarcinoma (GAC) remains poor, and new therapeutic approaches are urgently needed. Claudin 6 (CLDN6) is an oncofetal antigen that is largely abs...

    Authors: Adrian Georg Simon, Su Ir Lyu, Mark Laible, Stefan Wöll, Özlem Türeci, Uğur Şahin, Hakan Alakus, Luca Fahrig, Thomas Zander, Reinhard Buettner, Christiane Josephine Bruns, Wolfgang Schroeder, Florian Gebauer and Alexander Quaas
    Citation: Journal of Translational Medicine 2023 21:552
  37. Bladder cancer is a urological carcinoma with high incidence, among which muscle invasive bladder cancer (MIBC) is a malignant carcinoma with high mortality. There is an urgent need to develop new drugs with l...

    Authors: Ruijiao Chen, Xiaopeng Hao, Jingyuan Chen, Changyue Zhang, Huixia Fan, Fuming Lian, Xiaochuan Chen, Chao Wang and Yong Xia
    Citation: Journal of Translational Medicine 2023 21:549
  38. Neuroendocrine tumors (NETs) early diagnosis is a clinical challenge that require a deep understanding of molecular and genetic features of this heterogeneous group of neoplasms. However, few biomarkers exist ...

    Authors: Federica Campolo, Franz Sesti, Tiziana Feola, Giulia Puliani, Antongiulio Faggiano, Maria Grazia Tarsitano, Marta Tenuta, Valeria Hasenmajer, Elisabetta Ferretti, Monica Verrico, Daniele Gianfrilli, Mary Anna Venneri, Andrea M. Isidori and Elisa Giannetta
    Citation: Journal of Translational Medicine 2023 21:548
  39. Resistance to pemetrexed (PEM), a rare chemotherapeutic agent that can efficiently cross the blood-brain barrier, limits the therapeutic efficacy for patients with lung cancer brain metastasis (BM). Aldo-keto ...

    Authors: Wenzhe Duan, Wenwen Liu, Shengkai Xia, Yang Zhou, Mengyi Tang, Mingxin Xu, Manqing Lin, Xinyu Li and Qi Wang
    Citation: Journal of Translational Medicine 2023 21:547
  40. ABCA4, the gene implicated in Stargardt disease (STGD1), contains 50 exons, of which 17 contain multiples of three nucleotides. The impact of in-frame exon skipping is yet to be determined. Antisense oligonucleot...

    Authors: Melita Kaltak, Rocio Blanco-Garavito, Laurie L. Molday, Claire-Marie Dhaenens, Eric E. Souied, Gerard Platenburg, Jim Swildens, Robert S. Molday and Frans P. M. Cremers
    Citation: Journal of Translational Medicine 2023 21:546
  41. Peripheral nerve injury can cause neuroinflammation and neuromodulation that lead to mitochondrial dysfunction and neuronal apoptosis in the dorsal root ganglion (DRG) and spinal cord, contributing to neuropat...

    Authors: Yaseen Awad-Igbaria, Nadine Ferreira, Ali Keadan, Reem Sakas, Doron Edelman, Alon Shamir, Jean Francous-Soustiel and Eilam Palzur
    Citation: Journal of Translational Medicine 2023 21:545
  42. Tumour necrosis factor superfamily protein 14 (TNFSF14), also called LIGHT, is an important regulator of immunological and fibrosis diseases. However, its specific involvement in cardiac fibrosis and atrial fi...

    Authors: Yirong Wu, Siyao Zhan, Lian Chen, Mingrui Sun, Miaofu Li, Xuanting Mou, Zhen Zhang, Linhao Xu and Yizhou Xu
    Citation: Journal of Translational Medicine 2023 21:544
  43. The ventral tegmental area (VTA) contains heterogeneous cell populations. The dopaminergic neurons in VTA play a central role in reward and cognition, while CamKIIα-positive neurons, composed mainly of glutama...

    Authors: Ning Zheng, Zhu Gui, Xiaodong Liu, Yang Wu, Huadong Wang, Aoling Cai, Jinfeng Wu, Xihai Li, Challika Kaewborisuth, Zhijian Zhang, Qitian Wang, Anne Manyande, Fuqiang Xu and Jie Wang
    Citation: Journal of Translational Medicine 2023 21:543
  44. Renal artery Doppler sonography with resistive index (RI) determination is a noninvasive, fast, and reliable diagnostic tool increasingly used in the intensive care unit (ICU) to predict and assess the reversi...

    Authors: Stéphanie Ruiz, Fanny Vardon-Bounes, Marie Virtos, Thierry Seguin, Laure Crognier, Antoine Rouget, Bernard Georges, Jean-Marie Conil and Vincent Minville
    Citation: Journal of Translational Medicine 2023 21:541
  45. Cyclooxygenase (COX)-2 is a rate-limiting enzyme in the biosynthesis of prostanoids, which is mostly inducible by inflammatory cytokines. The participation of COX-2 in the maturation of megakaryocytes has been...

    Authors: Xibing Zhuang, Pengcheng Xu, Yang Ou, Xia Shao, Ying Li, Yanna Ma, Shanshan Qin, Fanli Hua, Yanxia Zhan, Lili Ji, Tiankui Qiao, Hao Chen and Yunfeng Cheng
    Citation: Journal of Translational Medicine 2023 21:540
  46. Limited research has been conducted on the potential relationship between the dietary inflammation index (DII) and mortality, particularly in individuals with Helicobacter pylori (H. pylori) infection. This st...

    Authors: Yu-Jun Xiong, Lei-Lei Du, Yun-Lian Diao, Jun Wen, Xiang-Bin Meng, Jun Gao, Chun-Li Shao, Wen-Yao Wang, Xing-yun Zhu and Yi-Da Tang
    Citation: Journal of Translational Medicine 2023 21:538

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