Articles

Effects of physiological aging factor on bone tissue engineering repair based on fetal BMSCs

At present, many laboratories and hospitals all over the world are attempting and exploring the clinical transformation of this tissue engineered bone graft (TEBG) strategy. Many successful cases of bone tissu...

Authors: Dingyu Wu, Zhenxing Wang, Zhiwei Zheng, Yingnan Geng, Zhanzhao Zhang, Qiannan Li, Quan Zhou, Yilin Cao and Zhi-Yong Zhang

N-glycosylation patterns of plasma proteins and immunoglobulin G in chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a complex condition, whose diagnosis requires spirometric assessment. However, considering its heterogeneity, subjects with similar spirometric parameters do not...

Authors: Tamara Pavić, Dario Dilber, Domagoj Kifer, Najda Selak, Toma Keser, Đivo Ljubičić, Andrea Vukić Dugac, Gordan Lauc, Lada Rumora and Olga Gornik

Evaluation of four clinical laboratory parameters for the diagnosis of myalgic encephalomyelitis

Myalgic encephalomyelitis (ME) is a complex and debilitating disease that often initially presents with flu-like symptoms, accompanied by incapacitating fatigue. Currently, there are no objective biomarkers or...

Authors: Kenny L. De Meirleir, Tatjana Mijatovic, Krishnamurthy Subramanian, Karen A. Schlauch and Vincent C. Lombardi

Optimizing bone wound healing using BMP2 with absorbable collagen sponge and Talymed nanofiber scaffold

Bone is a highly vascularized and resilient organ with innate healing abilities, however some bone injuries overwhelm these attributes and require intervention, such as bone tissue engineering strategies. Comb...

Authors: Emily L. Durham, R. Nicole Howie, SarahRose Hall, Nicholas Larson, Brayden Oakes, Reed Houck, Zachary Grey, Martin Steed, Amanda C. LaRue, Robin Muise-Helmericks and James Cray

Clinicopathologic implication of PD-L1 and phosphorylated STAT3 expression in diffuse large B cell lymphoma

Antitumor immune response of programmed cell death ligand (PD-L1) has shown clinical value not only in Hodgkin lymphoma and EBV-associated lymphomas but also in EBV-negative diffuse large B cell lymphoma (DLBC...

Authors: Hyun Jung Kwon, Jeong Mi Yang, Jeong-Ok Lee, Jong Seok Lee and Jin Ho Paik

Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway

Endoplasmic reticulum (ER) stress, which can promote lipid metabolism disorders and steatohepatitis, contributes significantly to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Calcium (Ca²⁺) homeo...

Authors: Xiaobo Gao, Shun Guo, Song Zhang, An Liu, Lei Shi and Yan Zhang

Proceedings of the 6th Annual United States Army Institute of Surgical Research Summer Undergraduate Research Internship Program 2018

Authors:

Possibility of avoiding axillary lymph node dissection by immune microenvironment monitoring in preoperative chemotherapy for breast cancer

The diagnosis of metastasis by sentinel lymph node biopsy (SLNB) in early breast cancer surgery provides an accurate view of the state of metastases to the axillary lymph nodes, and it has now become the stand...

Authors: Koji Takada, Shinichiro Kashiwagi, Wataru Goto, Yuka Asano, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

NLRC5: potential novel non-invasive biomarker for predicting and reflecting the progression of IgA nephritis

The nucleotide oligomerization domain-like receptor subfamily C5 (NLRC5) is primarily expressed in the adaptive and innate immune systems. NLRC5 was recently discovered to regulate immunity and inflammatory re...

Authors: Yusa Chen, Huihui Li, Chenggen Xiao, Xiangli Zeng, Xiangcheng Xiao, Qiaoling Zhou and Ping Xiao

Serum uromodulin and progression of kidney disease in patients with chronic kidney disease

Uromodulin is specifically synthesized and secreted by kidney tubular epithelial cells. Studies on the association of serum uromodulin and outcomes of chronic kidney disease (CKD) are lacking. This study aimed...

Authors: Li Lv, Jinwei Wang, Bixia Gao, Liang Wu, Fang Wang, Zhao Cui, Kevin He, Luxia Zhang, Min Chen and Ming-Hui Zhao

Associations of immunological factors with metabolic syndrome and its characteristic elements in Chinese centenarians

Metabolic syndrome (MetS) has an increased prevalence (approximately 20–25% of the adult population) all over the world. Immunological function is significantly associated with the development of MetS, and Met...

Authors: Shihui Fu, Yao Yao, Faqin Lv, Fu Zhang, Yali Zhao and Fuxin Luan

Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia

The cytokine, interleukin-18 (IL-18), was originally identified as an interferon-γ-inducing proinflammatory factor; however, there is increasing evidence suggesting that it has non-immunological effects on phy...

Authors: Kyosuke Yamanishi, Seishi Maeda, Sachi Kuwahara-Otani, Takuya Hashimoto, Kaoru Ikubo, Keiichiro Mukai, Keiji Nakasho, Naomi Gamachi, Yosif El-Darawish, Wen Li, Daisuke Okuzaki, Yuko Watanabe, Hiromichi Yamanishi, Haruki Okamura and Hisato Matsunaga

Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury

Sirtuin 3 (Sirt3) is a key regulator of energy metabolism and oxidative stress. To investigate the role of Sirt3 in contrast-induced acute kidney injury (CIAKI), we established the model both in vivo and in vi...

Authors: Qinghai Zhang, Xun Liu, Na li, Jihong Zhang, Jianmin Yang and Peili Bu

Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study

To examine serum angiopoietin-2 (Angpt-2) in relation to malnutrition, inflammation, atherosclerosis and cardiac valvular calcification, so-called MIAC syndrome and its predictive role in outcomes of peritonea...

Authors: Xiaoxiao Yang, He Zhang, Yuanyuan Shi, Zanzhe Yu, Hao Yan, Zhaohui Ni, Jiaqi Qian and Wei Fang

Platycodin D inhibits platelet function and thrombus formation through inducing internalization of platelet glycoprotein receptors

Platycodin D (PD) is one of the major bioactive components of the roots of Platycodon grandiflorum and possesses multiple biological and pharmacological properties, such as antiviral, anti-inflammatory, and anti-...

Authors: Qi Luo, Guangyu Wei, Xiaoqing Wu, Kai Tang, Mengdi Xu, Yulu Wu, Yun Liu, Xiaoqian Li, Zengtian Sun, Wen Ju, Kunming Qi, Chong Chen, Zhiling Yan, Hai Cheng, Feng Zhu, Zhenyu Li…

GAP43, a novel metastasis promoter in non-small cell lung cancer

Brain metastasis is an extremely serious sequela with a dismal prognosis in non-small cell lung cancer (NSCLC). The present study aimed to identify novel biomarkers and potential therapeutic targets for brain ...

Authors: Fanrong Zhang, Lisha Ying, Jiaoyue Jin, Jianguo Feng, Kaiyan Chen, Minran Huang, Yingxue Wu, Herbert Yu and Dan Su

High density lipoprotein cholesterol and proteome in SR-B1 KO mice: lost in precipitation

Scavenger receptor class B type 1 (SR-B1) plays an essential role in high density lipoprotein (HDL) metabolism. SR-B1 deficient (SR-B1 KO) mice are prone to atherosclerosis and exhibit abnormally large, choles...

Authors: Susana Contreras-Duarte, Nicolás Santander, Ruth Birner-Gruenberger, Christian Wadsack, Attilio Rigotti and Dolores Busso

Influence of FTO rs9939609 and Mediterranean diet on body composition and weight loss: a randomized clinical trial

The Mediterranean diet (MeD) plays a key role in the prevention of obesity. Among the genes involved in obesity, the Fat mass and obesity-associated gene (FTO) is one of the most known, but its interaction wit...

Authors: Laura Di Renzo, Giorgia Cioccoloni, Simone Falco, Ludovico Abenavoli, Alessandra Moia, Paola Sinibaldi Salimei and Antonino De Lorenzo

Significance of intrinsic breast cancer subtypes on the long-term prognosis after neoadjuvant chemotherapy

The prognosis of breast cancer and the treatment response to neoadjuvant chemotherapy (NAC) differ depending on the intrinsic molecular subtypes. We evaluated the prognostic significance of immunohistological ...

Authors: Wataru Goto, Shinichiro Kashiwagi, Koji Takada, Yuka Asano, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

Simvastatin attenuates tibial bone loss in rats with type 1 diabetes and periodontitis

Diabetes induces long bone loss and aggravation of periodontitis-induced alveolar bone loss. Simvastatin (SIM), which is a lipid-lowering agent is known to have an anabolic effect on bone. Therefore, we invest...

Authors: Ae Ri Kim, Ji-Hye Kim, Aeryun Kim, Yongsung Sohn, Jeong-Heon Cha, Eun-Jung Bak and Yun-Jung Yoo

Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail

The pharmaceutical industry is in the midst of a productivity crisis and rates of translation from bench to bedside are dismal. Patients are being let down by the current system of drug discovery; of the sever...

Authors: Pandora Pound and Merel Ritskes-Hoitinga

Status of programmed death-ligand 1 expression in sarcomas

Sarcomas are challenging to study because of their rarity and histomorphological complexity. PD1 and PD-L1 inhibitors showed a promising anti-tumor effect in solid tumors, where a relationship between PD-L1 ex...

Authors: Hyung Kyu Park, Mingi Kim, Minjung Sung, Seung Eun Lee, Yu Jin Kim and Yoon-La Choi

Periostin involved in the activated hepatic stellate cells-induced progression of residual hepatocellular carcinoma after sublethal heat treatment: its role and potential for therapeutic inhibition

Incomplete thermal ablation may induce invasiveness of hepatocellular carcinoma (HCC). Here, we investigated whether activated hepatic stellate cells (HSCs) would accelerate the progression of residual HCC aft...

Authors: Rui Zhang, Xia-Hui Lin, Min Ma, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui and Rong-Xin Chen

Analysis of longitudinal semicontinuous data using marginalized two-part model

Connective tissue growth factor (CTGF), is a secreted matricellular factor that has been linked to increased risk of cardiovascular disease in diabetic subjects. Despite the biological role of CTGF in diabetes...

Authors: Miran A. Jaffa, Mulugeta Gebregziabher, Sara M. Garrett, Deirdre K. Luttrell, Kenneth E. Lipson, Louis M. Luttrell and Ayad A. Jaffa

Fragment size and level of cell-free DNA provide prognostic information in patients with advanced pancreatic cancer

It was recently demonstrated that the size of cell-free DNA (cfDNA) fragments that originates from tumor cells are shorter than cfDNA fragments that originates from non-malignant cells. We investigated whether...

Authors: Morten Lapin, Satu Oltedal, Kjersti Tjensvoll, Tove Buhl, Rune Smaaland, Herish Garresori, Milind Javle, Nils Idar Glenjen, Bente Kristin Abelseth, Bjørnar Gilje and Oddmund Nordgård

Galectin-3 predicts response and outcomes after cardiac resynchronization therapy

Cardiac resynchronization therapy (CRT) reduces symptoms, morbidity and mortality in chronic heart failure patients with wide QRS complexes. However, approximately one third of CRT patients are non-responders....

Authors: Clémentine Andre, Eric Piver, Romain Perault, Arnaud Bisson, Julien Pucheux, Emmanuelle Vermes, Bertrand Pierre, Laurent Fauchier, Dominique Babuty and Nicolas Clementy

Peptide vaccine against chikungunya virus: immuno-informatics combined with molecular docking approach

Chikungunya virus (CHIKV), causes massive outbreaks of chikungunya infection in several regions of Asia, Africa and Central/South America. Being positive sense RNA virus, CHIKV replication within the host resu...

Authors: Muhammad Tahir ul Qamar, Amna Bari, Muhammad Muzammal Adeel, Arooma Maryam, Usman Ali Ashfaq, Xiaoyong Du, Iqra Muneer, Hafiz Ishfaq Ahmad and Jia Wang

Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance

Neurogenin3 (Ngn3) and neurogenic differentiation 1 (NeuroD1), two crucial transcriptional factors involved in human diabetes (OMIM: 601724) and islet development, have been previously found to directly target...

Authors: Lin Wang, Zhong Sheng Sun, Bingwu Xiang, Chi-ju Wei, Yan Wang, Kevin Sun, Guanjie Chen, Michael S. Lan, Gilberto N. Carmona, Abner L. Notkins and Tao Cai

The immune response to sub-clinical mastitis is impaired in HIV-infected women

Subclinical mastitis (SCM) is relatively common in lactating women and may be associated with HIV shedding in breast milk. The potential association between HIV infection and breast milk immunologic factors an...

Authors: Roxane Schaub, Stéphanie Badiou, Johannes Viljoen, Pierre Dujols, Karine Bolloré, Philippe Van de Perre, Marie-Louise Newell, Ruth Bland, Nicolas Nagot and Edouard Tuaillon

An increase in myocardial 18-fluorodeoxyglucose uptake is associated with left ventricular ejection fraction decline in Hodgkin lymphoma patients treated with anthracycline

Doxorubicin (DOX)-based chemotherapy for Hodgkin lymphoma (HL) yields excellent disease-free survival, but poses a substantial risk of subsequent left ventricular (LV) dysfunction and heart failure, typically ...

Authors: Matteo Sarocchi, Matteo Bauckneht, Eleonora Arboscello, Selene Capitanio, Cecilia Marini, Silvia Morbelli, Maurizio Miglino, Angela Giovanna Congiu, Giorgio Ghigliotti, Manrico Balbi, Claudio Brunelli, Gianmario Sambuceti, Pietro Ameri and Paolo Spallarossa

CD25 and TGF-β blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains poor due to the difficulty of disease diagnosis and therapy. Immunotherapy has had robust performance against several malignancies, including PD...

Authors: Ning Pu, Guochao Zhao, Hanlin Yin, Jian-ang Li, Abulimiti Nuerxiati, Dansong Wang, Xuefeng Xu, Tiantao Kuang, Dayong Jin, Wenhui Lou and Wenchuan Wu

iTRAQ-based quantitative analysis of age-specific variations in salivary proteome of caries-susceptible individuals

Human saliva is a protein-rich, easily accessible source of potential biomarkers for the diagnosis of oral and systemic diseases. However, little is known about the changes in salivary proteome associated with...

Authors: Kun Wang, Xiuqing Wang, Sainan Zheng, Yumei Niu, Wenyue Zheng, Xi Qin, Zhongcheng Li, Junyuan Luo, Wentao Jiang, Xuedong Zhou, Wei Li and Linglin Zhang

Genomic approaches in the search for molecular biomarkers in chronic kidney disease

Chronic kidney disease (CKD) is recognised as a global public health problem, more prevalent in older persons and associated with multiple co-morbidities. Diabetes mellitus and hypertension are common aetiolog...

Authors: M. Cañadas-Garre, K. Anderson, J. McGoldrick, A. P. Maxwell and A. J. McKnight

Stability enhancement of clinical grade multipotent mesenchymal stromal cell-based products

Successful delivery of cell-based therapeutics into patients is compromised by their short shelf-life upon release from production facilities due to the living nature of the active component that rapidly loses...

Authors: Clémentine Mirabel, Eduard Puente-Massaguer, Anna del Mazo-Barbara, Blanca Reyes, Philip Morton, Francesc Gòdia and Joaquim Vives

Podocalyxin-like protein as a predictive biomarker for benefit of neoadjuvant chemotherapy in resectable gastric and esophageal adenocarcinoma

We have previously shown that podocalyxin-like protein (PODXL) is a prognostic biomarker for poor survival in gastric and esophageal adenocarcinoma treated with surgery up-front. The aim of the present study w...

Authors: David Borg, Anna H. Larsson, Charlotta Hedner, Björn Nodin, Anders Johnsson and Karin Jirström

Heterogeneity of insulin resistance and beta cell dysfunction in gestational diabetes mellitus: a prospective cohort study of perinatal outcomes

Insulin resistance and beta cell dysfunction were reported to be responsible for gestational diabetes mellitus (GDM). However, little is known about the heterogeneity of these factors and its influences on per...

Authors: Yingfeng Liu, Wolin Hou, Xiyan Meng, Weijing Zhao, Jiemin Pan, Junling Tang, Yajuan Huang, Minfang Tao and Fang Liu

A modified method for isolation of human cardiomyocytes to model cardiac diseases

Cardiomyocytes derived from animals and induced pluripotent stem cells (iPSCs) are two main cellular models to study cardiovascular diseases, however, neither provides precise modeling of the response of matur...

Authors: Guang-ran Guo, Liang Chen, Man Rao, Kai Chen, Jiang-ping Song and Sheng-shou Hu

Analysis of circulating tumour cell and the epithelial mesenchymal transition (EMT) status during eribulin-based treatment in 22 patients with metastatic breast cancer: a pilot study

Liquid biopsy approaches, such as measuring circulating tumour cells (CTCs), have recently been introduced in several clinical studies. However, the development of CTCs as a predictive marker for treatment eff...

Authors: Yoshiya Horimoto, Emi Tokuda, Fumi Murakami, Toshitaka Uomori, Takanori Himuro, Katsuya Nakai, Gotaro Orihata, Kotaro Iijima, Shinsaku Togo, Hideo Shimizu and Mitsue Saito

Unique true predicted neoantigens (TPNAs) correlates with anti-tumor immune control in HCC patients

A novel prediction algorithm is needed for the identification of effective tumor associated mutated neoantigens. Only those with no homology to self wild type antigens are true predicted neoantigens (TPNAs) an...

Authors: Annacarmen Petrizzo, Maria Tagliamonte, Angela Mauriello, Valerio Costa, Marianna Aprile, Roberta Esposito, Andrea Caporale, Antonio Luciano, Claudio Arra, Maria Lina Tornesello, Franco M. Buonaguro and Luigi Buonaguro

Joint associations of serum uric acid and ALT with NAFLD in elderly men and women: a Chinese cross-sectional study

Epidemiological evidence suggests sex difference in serum uric acid (SUA) and alanine aminotransferase (ALT) might be a potential explanation for the gender difference in prevalence of non-alcoholic fatty live...

Authors: Huanhuan Yang, Deming Li, Xiaochao Song, Fang Liu, Xinjing Wang, Qinghua Ma, Xi Zhang and Xinli Li

Upregulation of miR-196b-5p attenuates BCG uptake via targeting SOCS3 and activating STAT3 in macrophages from patients with long-term cigarette smoking-related active pulmonary tuberculosis

Cigarette smoking (CS) triggers an intense and harmful inflammatory response in lungs mediated by alveolar and blood macrophages, monocytes, and neutrophils and is closely associated with prevalence of tubercu...

Authors: Yaoqin Yuan, Dongzi Lin, Long Feng, Mingyuan Huang, Huimin Yan, Yumei Li, Yinwen Chen, Bihua Lin, Yan Ma, Ziyu Ye, Yuezhi Mei, Xiaolin Yu, Keyuan Zhou, Qunzhou Zhang, Tao Chen and Jincheng Zeng

Correction to: Harnessing Qatar Biobank to understand type 2 diabetes and obesity in adult Qataris from the First Qatar Biobank Project

Following publication of the original article [1], the authors reported that one of the authors’ names was processed incorrectly. In this Correction the incorrect and correct author name are shown. The origina...

Authors: Ehsan Ullah, Raghvendra Mall, Reda Rawi, Naima Moustaid-Moussa, Adeel A. Butt and Halima Bensmail

p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification

Malignant pleural mesothelioma (MPM) is an orphan disease that is difficult to treat using traditional chemotherapy, an approach which has been effective in other types of cancer. Most chemotherapeutics cause ...

Authors: Kun Tian, Emyr Bakker, Michelle Hussain, Alice Guazzelli, Hasen Alhebshi, Parisa Meysami, Constantinos Demonacos, Jean-Marc Schwartz, Luciano Mutti and Marija Krstic-Demonacos

Boswellia frereana suppresses HGF-mediated breast cancer cell invasion and migration through inhibition of c-Met signalling

Hepatocyte growth factor (HGF) plays a pivotal role in breast cancer cell motility, invasion and angiogenesis. These pro-metastatic events are triggered through HGF coupling and activation of the c-Met recepto...

Authors: Christian Parr and Ahmed Y. Ali

The development of a Biobank of cancer tissue samples from World Trade Center responders

World Trade Center (WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. Studies of cancer incidence in this population have reported elevated risks of cancer compared to the gene...

Authors: Wil Lieberman-Cribbin, Stephanie Tuminello, Christina Gillezeau, Maaike van Gerwen, Rachel Brody, Michael Donovan and Emanuela Taioli

A lipidated bi-epitope vaccine comprising of MHC-I and MHC-II binder peptides elicits protective CD4 T cell and CD8 T cell immunity against Mycobacterium tuberculosis

The clinical trials conducted at Chingleput India suggest that BCG fails to protect against tuberculosis (TB) in TB-endemic population. Recent studies advocate that non-tuberculous mycobacteria and latent Mycobac...

Authors: Pradeep K. Rai, Sathi Babu Chodisetti, Sudeep K. Maurya, Sajid Nadeem, Weiguang Zeng, Ashok K. Janmeja, David C. Jackson and Javed N. Agrewala

Establishment of urinary exosome-like vesicles isolation protocol for FHHNC patients and evaluation of different exosomal RNA extraction methods

Molecular and cellular pathophysiological events occurring in the majority of rare kidney diseases remain to be elucidated. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare au...

Authors: M. Vall-Palomar, J. Arévalo, G. Ariceta and A. Meseguer

Plasma interleukin-37 is increased and inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells in systemic juvenile idiopathic arthritis patients

Interleukin (IL)-37 has emerged as a novel anti-inflammatory cytokine that play an immunosuppressive role in regulating inflammatory response. This study aimed to measure IL-37 levels in the plasma and periphe...

Authors: Miao Feng, Min Kang, Feng He, Zonghui Xiao, Zhewei Liu, Hailan Yao and Jianxin Wu

Tailoring cells for clinical needs: Meeting report from the Advanced Therapy in Healthcare symposium (October 28–29 2017, Doha, Qatar)

New technologies and therapies designed to facilitate development of personalized treatments are rapidly emerging in the field of biomedicine. Strikingly, the goal of personalized medicine refined the concept ...

Authors: Sara Deola, Bella S. Guerrouahen, Heba Sidahmed, Anjud Al-Mohannadi, Muhammad Elnaggar, Ramaz Elsadig, Essam M. Abdelalim, Goran Petrovski, Massimo Gadina, Adrian Thrasher, Winfried S. Wels, Stephen P. Hunger, Ena Wang, Francesco M. Marincola, Cristina Maccalli and Chiara Cugno

Correction to: Cytokines induced killer cells produced in good manufacturing practices conditions: identification of the most advantageous and safest expansion method in terms of viability, cellular growth and identity

Following publication of the original article [1], the authors reported that all of the authors’ names were processed incorrectly so that their given and family names were interchanged. In this Correction the ...

Authors: Sara Castiglia, Aloe Adamini, Deborah Rustichelli, Laura Castello, Katia Mareschi, Giuseppe Pinnetta, Marco Leone, Alessandra Mandese, Ivana Ferrero, Giulia Mesiano and Franca Fagioli