Articles

Ibrutinib protects T cells in patients with CLL from proliferation-induced senescence

The development of Bruton’s tyrosine kinase inhibitors (BTKi) for the treatment of chronic lymphocytic leukaemia (CLL) has provided a highly effective and relatively non-toxic alternative to conventional chemo...

Authors: Joanne E. Davis, Chia Sharpe, Kylie Mason, Constantine S. Tam, Rachel M. Koldej and David S. Ritchie

The health risks of dysphagia for patients with head and neck cancer: a multicentre prospective observational study

It is well known that malnutrition is a frequent co-morbidity in cancer patients, especially in those with head and neck neoplasms. This may be due both to the presence of dysphagia symptoms and to the appeara...

Authors: Maria Giulia Cristofaro, Ida Barca, Francesco Ferragina, Daniela Novembre, Yvelise Ferro, Roberta Pujia and Tiziana Montalcini

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

There is accumulating evidence of endothelial dysfunction, muscle and cerebral hypoperfusion in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In this paper we deduce the pathomechanisms resultin...

Authors: Klaus J. Wirth, Carmen Scheibenbogen and Friedemann Paul

Overexpression of E3 ubiquitin ligase Cbl attenuates endothelial dysfunction in diabetes mellitus by inhibiting the JAK2/STAT4 signaling and Runx3-mediated H3K4me3

Diabetes mellitus (DM), a most common chronic disease, is featured with impaired endothelial function and bioavailability of nitric oxide (NO), while E3 ubiquitin ligase appears to alleviate endothelial dysfun...

Authors: Qingsong Jin, Liangyan Lin, Tiantian Zhao, Xiaoyan Yao, Yaqin Teng, Dongdong Zhang, Yongjun Jin and Meizi Yang

Identification of the regulatory role of lncRNA HCG18 in myasthenia gravis by integrated bioinformatics and experimental analyses

Long non-coding RNAs (lncRNAs), functioning as competing endogenous RNAs (ceRNAs), have been reported to play important roles in the pathogenesis of autoimmune diseases. However, little is known about the regu...

Authors: Shuang Li, Xu Wang, Tianfeng Wang, Huixue Zhang, Xiaoyu Lu, Li Liu, Lifang Li, Chunrui Bo, Xiaotong Kong, Si Xu, Shangwei Ning, Jianjian Wang and Lihua Wang

The inhibition of circular RNA circNOLC1 by propofol/STAT3 attenuates breast cancer stem cells function via miR-365a-3p/STAT3 signaling

Breast cancer remains one of the most dreadful female malignancies globally, in which cancer stem cells (CSCs) play crucial functions. Circular RNAs have drawn great attention in cancer research area and propo...

Authors: Yi-Ping Liu, Jin-Yu Heng, Xin-Yu Zhao and En-You Li

Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats

Despite the benefits of extracorporeal cardiopulmonary resuscitation (ECPR) in cohorts of selected patients with cardiac arrest (CA), extracorporeal membrane oxygenation (ECMO) includes an artificial oxygenati...

Authors: Tai Yin, Lance B. Becker, Rishabh C. Choudhary, Ryosuke Takegawa, Muhammad Shoaib, Koichiro Shinozaki, Yusuke Endo, Koichiro Homma, Daniel M. Rolston, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Tomoaki Aoki, Santiago J. Miyara…

Knockdown of long noncoding RNA GAS5 reduces vascular smooth muscle cell apoptosis by inactivating EZH2-mediated RIG-I signaling pathway in abdominal aortic aneurysm

Abdominal aortic aneurysm (AAA), an irreversible cardiovascular disease prevalent in the artery, causes the increase of the aneurysm diameter over time, and is a fatal phenomenon inducing sidewall rupture. Lon...

Authors: Tianming Le, Xin He, Jianhua Huang, Shuai Liu, Yang Bai and Kemin Wu

Monitoring the tissue perfusion during hemorrhagic shock and resuscitation: tissue-to-arterial carbon dioxide partial pressure gradient in a pig model

Despite much evidence supporting the monitoring of the divergence of transcutaneous partial pressure of carbon dioxide (tcPCO₂) from arterial partial pressure carbon dioxide (artPCO₂) as an indicator of the shock...

Authors: Yusuke Endo, Taku Hirokawa, Taku Miyasho, Ryosuke Takegawa, Koichiro Shinozaki, Daniel M. Rolston, Lance B. Becker and Kei Hayashida

Gene profiling of Toll-like receptor signalling pathways in neutrophils of patients with acute-on-chronic liver failure

Toll-like receptors (TLRs) on neutrophils play a crucial role in detecting pathogens and organ/tissue injury in acute-on-chronic liver failure (ACLF). However, little is known about the exact mechanisms and po...

Authors: Yi Zhang, Wei Wu, Yijie Wang, Lingjia Tong, Meng Hong, Qi Xia and Zhi Chen

Circular RNA circPIP5K1A contributes to cancer stemness of osteosarcoma by miR-515-5p/YAP axis

Osteosarcoma is a common type of bone tumors and frequently occurs in children and adolescents. Cancer stem cells (CSCs) are a unique sub-type of self-renewal cancer cells and the stemness of cancer cells are ...

Authors: Pengxu Shi, Yueting Li and Qingsheng Guo

Dexmedetomidine inhibits mitochondria damage and apoptosis of enteric glial cells in experimental intestinal ischemia/reperfusion injury via SIRT3-dependent PINK1/HDAC3/p53 pathway

Intestinal ischemia/reperfusion (I/R) injury commonly occurs during perioperative periods, resulting in high morbidity and mortality on a global scale. Dexmedetomidine (Dex) is a selective α2-agonist that is f...

Authors: Qin Zhang, Xiao-Ming Liu, Qian Hu, Zheng-Ren Liu, Zhi-Yi Liu, Huai-Gen Zhang, Yuan-Lu Huang, Qiu-Hong Chen, Wen-Xiang Wang and Xue-Kang Zhang

mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease which involves multiple body systems (e.g., immune, nervous, digestive, circulatory) and research domains (e.g., immunology...

Authors: Ravi Mathur, Megan U. Carnes, Alexander Harding, Amy Moore, Ian Thomas, Alex Giarrocco, Michael Long, Marcia Underwood, Christopher Townsend, Roman Ruiz-Esparza, Quinn Barnette, Linda Morris Brown and Matthew Schu

Interleukin-1 blockade in cardiac sarcoidosis: study design of the multimodality assessment of granulomas in cardiac sarcoidosis: Anakinra Randomized Trial (MAGiC-ART)

Sarcoidosis is an inflammatory disease characterized by the formation of granulomas, which involve the heart in up to 25% of patients. Cardiac sarcoidosis can lead to life threatening arrhythmias and heart fai...

Authors: Jordana Kron, Thomas Crawford, Virginia Mihalick, Frank Bogun, Jennifer H. Jordan, Todd Koelling, Huzaefah Syed, Aamer Syed, Thomas Iden, Kelly Polly, Emily Federmann, Kirsta Bray, Sangeeta Lathkar-Pradhan, Shilpa Jasti, Lynda Rosenfeld, David Birnie…

Contextual reprogramming of CAR-T cells for treatment of HER2⁺ cancers

Adoptive transfer of chimeric antigen receptor (CAR)-engineered T cells combined with checkpoint inhibition may prevent T cell exhaustion and improve clinical outcomes. However, the approach is limited by cumu...

Authors: Zhifen Yang, Lingyu Li, Ahu Turkoz, Pohan Chen, Rona Harari-Steinfeld, Maggie Bobbin, Ofir Stefanson, Hana Choi, Violena Pietrobon, Bennett Alphson, Angshumala Goswami, Vitaly Balan, Alper Kearney, Dharmesh Patel, Jin Yang, Damla Inel…

Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial

Induction of long-term synaptic depression (LTD) is proposed as a treatment mechanism for chronic pain but remains untested in clinical populations. Two interlinked studies; (1) A patient-assessor blinded, ran...

Authors: Selina Johnson, Anne Marshall, Dyfrig Hughes, Emily Holmes, Florian Henrich, Turo Nurmikko, Manohar Sharma, Bernhard Frank, Paul Bassett, Andrew Marshall, Walter Magerl and Andreas Goebel

Enjoy your journey: the bergamot polyphenols from the tree to the cell metabolism

Authors: Salvatore Nesci, Ernesto Palma, Vincenzo Mollace, Giovanni Romeo and Francesca Oppedisano

Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration

Periodontitis is a chronic inflammatory disease that leads to the destruction of both soft and hard periodontal tissues. Complete periodontal regeneration in clinics using the currently available treatment app...

Authors: Hongbing Lin, Huishan Chen, Xuetao Zhao, Zhen Chen, Peipei Zhang, Yue Tian, Yawei Wang, Tong Ding, Lijing Wang and Yuqin Shen

Circular RNA circ-ERBB2 promotes HER2-positive breast cancer progression and metastasis via sponging miR-136-5p and miR-198

Circular RNAs (circRNAs) are pivotal regulators of various human cancers and circ-ERBB2 is abnormally expressed in breast cancer cells. However, the role and mechanism of circ-ERBB2 in HER2-positive breast can...

Authors: Jin-xiu Zhong, Yun-yuan Kong, Rong-guang Luo, Guo-jin Xia, Wen-xing He, Xue-zhong Chen, Wei-wei Tan, Qing-jie Chen, Yu-yin Huang and Yan-xing Guan

Single-cell analysis revealed that IL4I1 promoted ovarian cancer progression

Ovarian cancer was one of the leading causes of female deaths. Patients with OC were essentially incurable and portends a poor prognosis, presumably because of profound genetic heterogeneity limiting reproduci...

Authors: Hongyu Zhao, Yu Teng, Wende Hao, Jie Li, Zhefeng Li, Qi Chen, Chenghong Yin and Wentao Yue

Combined cART including Tenofovir Disoproxil, Emtricitabine, and Dolutegravir has potent therapeutic effects in HIV-1 infected humanized mice

HIV-1 reservoirs persist in the presence of combined antiretroviral therapy (cART). However, cART has transformed HIV-1 infection into a chronic disease marked by control of HIV-1 viral load and mortality redu...

Authors: Matthew Weichseldorfer, Yvonne Affram, Alonso Heredia, Zahra Rikhtegaran-Tehrani, Mohammad M. Sajadi, Sumiko P. Williams, Yutaka Tagaya, Francesca Benedetti, Habib O. Ramadhani, Frank Denaro, Arshi Munawwar, Joseph Bryant, Davide Zella, Marvin Reitz, Fabio Romerio and Olga S. Latinovic

Gene therapy for cystic fibrosis: new tools for precision medicine

The discovery of the Cystic fibrosis (CF) gene in 1989 has paved the way for incredible progress in treating the disease such that the mean survival age of individuals living with CF is now ~58 years in Canada...

Authors: Jin-A Lee, Alex Cho, Elena N. Huang, Yiming Xu, Henry Quach, Jim Hu and Amy P. Wong

Identification and functional analysis of a three-miRNA ceRNA network in hypertrophic scars

Hypertrophic scar (HTS) is a fibrotic disorder of skins and may have repercussions on the appearance as well as functions of patients. Recent studies related have shown that competitive endogenous RNA (ceRNA) ...

Authors: Zewei Zhang, Xin Huang, Jiahao Yang, Shuchen Gu, Yixuan Zhao, Yunhan Liu, Yimin Khoong, Shuqi Wang, Shenying Luo, Tao Zan and Guangshuai Li

Avenues of research in dietary interventions to target tumor metabolism in osteosarcoma

Osteosarcoma (OS) is the most frequent primary bone cancer, affecting mostly children and adolescents. Although much progress has been made throughout the years towards treating primary OS, the 5-year survival...

Authors: Taiana Campos Leite, Rebecca Jean Watters, Kurt Richard Weiss and Giuseppe Intini

iTTCA-RF: a random forest predictor for tumor T cell antigens

Cancer is one of the most serious diseases threatening human health. Cancer immunotherapy represents the most promising treatment strategy due to its high efficacy and selectivity and lower side effects compar...

Authors: Shihu Jiao, Quan Zou, Huannan Guo and Lei Shi

Development and validation of new screening tool for predicting dementia risk in community-dwelling older Japanese adults

Established clinical assessments for detecting dementia risk often require time, cost, and face-to-face meetings. We aimed to develop a Simplified Telephone Assessment for Dementia risk (STAD) (a new screening...

Authors: Keitaro Makino, Sangyoon Lee, Seongryu Bae, Ippei Chiba, Kenji Harada, Osamu Katayama, Yohei Shinkai and Hiroyuki Shimada

Cytotoxic lymphocytes-related gene ITK from a systematic CRISPR screen could predict prognosis of ovarian cancer patients with distant metastasis

Ovarian cancer, a highly metastatic malignancy, has benefited tremendously from advances in modern human genomics. However, the genomic variations related to the metastasis remains unclear.

Authors: Mengyao Xu, Shan Huang, Jiahui Chen, Wanxue Xu, Rong Xiang, Yongjun Piao and Shuangtao Zhao

The role of PDGFRA as a therapeutic target in young colorectal cancer patients

Young patients with colorectal cancer (CRC) exhibit poor prognoses compared to older patients due to the difficulty in early diagnosis and treatment. However, the underlying molecular characteristics are still...

Authors: Tae Won Kim, Hye Kyung Hong, Chung Lee, Sunmin Kim, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Jung Wook Huh, Yoon Ah Park, Je-Gun Joung, Woong-Yang Park and Yong Beom Cho

Correction to: Nerve growth factor improves functional recovery by inhibiting endoplasmic reticulum stress-induced neuronal apoptosis in rats with spinal cord injury

An amendment to this paper has been published and can be accessed via the original article.

Authors: Hongyu Zhang, Fenzan Wu, Xiaoxia Kong, Jie Yang, Huijun Chen, Liancheng Deng, Yi Cheng, Libing Ye, Sipin Zhu, Xie Zhang, Zhouguang Wang, Hongxue Shi, Xiaobing Fu, Xiaokun Li, Huazi Xu, Li Lin…

Bioinformatics analysis reveals a stem cell-expressed circ-Serpine2-mediated miRNA-mRNA regulatory subnetwork in the malignant progression of glioma

High-grade glioma has a poor prognosis, and GSCs can have pivotal roles in glioma pathology. This study investigated GSC exosome-containing circRNA mechanisms affecting the malignant progression of glioma.

Authors: Guowei Li and Qing Lan

Radiomics-based machine learning analysis and characterization of breast lesions with multiparametric diffusion-weighted MR

This study aimed to evaluate the utility of radiomics-based machine learning analysis with multiparametric DWI and to compare the diagnostic performance of radiomics features and mean diffusion metrics in the ...

Authors: Kun Sun, Zhicheng Jiao, Hong Zhu, Weimin Chai, Xu Yan, Caixia Fu, Jie-Zhi Cheng, Fuhua Yan and Dinggang Shen

Correction to: Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial

Authors: Francesco Perrone, Maria Carmela Piccirillo, Paolo Antonio Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M. Marrocco-Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, Maria Lorenza Muiesan, Miriam Lichtner…

The recruitment mechanisms and potential therapeutic targets of podocytes from parietal epithelial cells

Podocytes are differentiated postmitotic cells which cannot be replaced after podocyte injury. The mechanism of podocyte repopulation after injury has aroused wide concern. Parietal epithelial cells (PECs) are...

Authors: Lihua Ni, Cheng Yuan and Xiaoyan Wu

An update on extra-oral bitter taste receptors

Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of bitterness. Although in the fir...

Authors: Kamila Tuzim and Agnieszka Korolczuk

DEL in China: the D antigen among serologic RhD-negative individuals

Providing RhD-negative red cell transfusions is a challenge in East Asia, represented by China, Korea, and Japan, where the frequency of RhD-negative is the lowest in the world.

Authors: Qinan Yin and Willy Albert Flegel

Correction to: Long noncoding RNA lncARSR promotes nonalcoholic fatty liver disease and hepatocellular carcinoma by promoting YAP1 and activating the IRS2/AKT pathway

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yuan Chi, Zheng Gong, He Xin, Ziwen Wang and Zhaoyu Liu

Immunobiology of cancer-associated fibroblasts in the context of radiotherapy

Radiotherapy (RT) still represents a mainstay of treatment in clinical oncology. Traditionally, the effectiveness of radiotherapy has been attributed to the killing potential of ionizing radiation (IR) over ma...

Authors: Turid Hellevik, Rodrigo Berzaghi, Kristin Lode, Ashraful Islam and Inigo Martinez-Zubiaurre

Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females

The number of older people is estimated to increase from 524 million in 2010 to 1.5 billion in 2050. The factors and models of human longevity and successful aging are questions that have intrigued individuals...

Authors: Shihui Fu, Ping Ping, Yulong Li, Bo Li, Yali Zhao, Yao Yao and Pei Zhang

Correction to: Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal cancer

Authors: Dan Wang, Weitang Yuan, Yaping Wang, Qian Wu, Li Yang, Feng Li, Xinfeng Chen, Zhen Zhang, Weina Yu, Nomathamsanqa Resegofetse Maimela, Ling Cao, Dong Wang, Junxia Wang, Zhenqiang Sun, Jinbo Liu and Yi Zhang

Correction to: Pirfenidone attenuates synovial fibrosis and postpones the progression of osteoarthritis by anti-fibrotic and anti-inflammatory properties in vivo and in vitro

Authors: Qilu Wei, Ning Kong, Xiaohui Liu, Run Tian, Ming Jiao, Yiyang Li, Huanshuai Guan, Kunzheng Wang and Pei Yang

Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing

Colorectal carcinoma (CRC) harboring oncogenic fusions has been reported to be highly enriched in mismatch repair deficient (dMMR) tumors with MLH1 hypermethylation (MLH1^me+) and wild-type BRAF and RAS. In this s...

Authors: Jing Wang, Ruiyu Li, Junjie Li, Yuting Yi, Xiaoding Liu, Jingci Chen, Hui Zhang, Junliang Lu, Cami Li, Huanwen Wu and Zhiyong Liang

MiR-144-3p inhibits gastric cancer progression and stemness via directly targeting GLI2 involved in hedgehog pathway

Gastric cancer (GC) is the fifth most commonly diagnosed cancer worldwide. Due to the dismal prognosis, identifying novel therapeutic targets in GC is urgently needed. Evidences have shown that miRNAs played c...

Authors: Yixun Lu, Benlong Zhang, Baohua Wang, Di Wu, Chuang Wang, Yunhe Gao, Wenquan Liang, Hongqing Xi, Xinxin Wang and Lin Chen

Clinical outcomes and safety of polymyxin B in the treatment of carbapenem-resistant Gram-negative bacterial infections: a real-world multicenter study

High morbidity and mortality due to carbapenem-resistant Gram-negative bacilli (CR-GNB) has led to the resurgence of polymyxin B (PMB) use in the last decade. The aim of our multicenter, real-world study was t...

Authors: Xiaojuan Zhang, Shaoyan Qi, Xiaoguang Duan, Bing Han, Shuguang Zhang, Shaohua Liu, Haixu Wang, Haibo Zhang and Tongwen Sun

Chronic itch induced by thalamic deep brain stimulation: a case for a central itch centre

Central itch syndrome has been previously described in conditions such as stroke. The neurophysiology of central itch syndrome has been investigated in non-human primates but remains incompletely understood.

Authors: Luciano Furlanetti, Harutomo Hasegawa, Natasha Hulse, Rachael Morris-Jones and Keyoumars Ashkan

miR-3065-3p promotes stemness and metastasis by targeting CRLF1 in colorectal cancer

Colorectal cancer is one of the most common malignancy in the world. It has been reported that cancer stem cells (CSCs) serve as the primary drivers of tumorigenesis and tumor progression. There is an urgent n...

Authors: Yifan Li, Jing Xun, Botao Wang, Yuan Ma, Lanqiu Zhang, Lei Yang, Ruifang Gao, Jun Guan, Tianyu Liu, Hejun Gao, Ximo Wang and Qi Zhang

Effect of the spatial–temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse

In the ovarian follicle, the Theca Cells (TCs) have two main functions: preserving morphological integrity and, importantly, secreting steroid androgen hormones. TCs express the essential enzyme 17α-hydroxylas...

Authors: Christian Secchi, Martina Belli, Tracy N. H. Harrison, Joseph Swift, CheMyong Ko, Antoni J. Duleba, Dwayne Stupack, R. Jeffrey Chang and Shunichi Shimasaki

Angiopoietin-1: an early biomarker of diabetic nephropathy?

Authors: Alexandra E. Butler, Ahmed Al-Qaissi, Thozhukat Sathyapalan and Stephen L. Atkin

Is human platelet lysate (hPL) the ideal candidate to substitute the foetal bovine serum for cell-therapy translational research?

Authors: M. Guiotto, M. O. Riehle, W. Raffoul, A. Hart and P. G. di Summa

Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA

The function and regulatory mechanism of FBXO43 in breast cancer (BC) are still unclear. Here, we intended to determine the role and mechanism of FBXO43 in BC.

Authors: Rulan Ma, Kun Zhu, Dawei Yuan, Meijun Gong, Yijun Li, Kang Li and Lei Meng

Long-term exposure to air pollution and the risk of developing sudden sensorineural hearing loss

The association between exposure to air pollution and sudden sensorineural hearing loss (SSNHL) has not been extensively discussed in the literature. Therefore, we conducted this nationwide study to evaluate t...

Authors: Stella Chin-Shaw Tsai, Yi-Chao Hsu, Jung-Nien Lai, Ruey-Hwang Chou, Hueng-Chuen Fan, Frank Cheau-Feng Lin, Ruihong Zhang, Cheng-Li Lin and Kuang-Hsi Chang