Articles

A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine

Recently, mesenchymal stem/stromal cells (MSCs) due to their pro-angiogenic, anti-apoptotic, and immunoregulatory competencies along with fewer ethical issues are presented as a rational strategy for regenerat...

Authors: Soudeh Moghadasi, Marischa Elveny, Heshu Sulaiman Rahman, Wanich Suksatan, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Alexei Valerievich Yumashev, Siavash Shariatzadeh, Roza Motavalli, Farahnaz Behzad, Faroogh Marofi, Ali Hassanzadeh, Yashwant Pathak and Mostafa Jarahian

The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with molecular heterogeneity, inducing differences in biological behavior, and therapeutic strategy. NGS profiles of pathogenic alterations in the Chi...

Authors: Lin Shui, Xiaofen Li, Yang Peng, Jiangfang Tian, Shuangshuang Li, Du He, Ang Li, Bole Tian, Mao Li, Heli Gao, Ning An, Cheng Yi and Dan Cao

Using genetic variants to evaluate the causal effect of serum vitamin D concentration on COVID-19 susceptibility, severity and hospitalization traits: a Mendelian randomization study

The coronavirus disease 2019 (COVID-19) pandemic has struck globally and is exerting a devastating toll on humans. The pandemic has led to calls for widespread vitamin D supplementation in public. However, evi...

Authors: Zhiyong Cui and Yun Tian

WT1 and ACE mRNAs of blood extracellular vesicle as biomarkers of diabetic nephropathy

Diabetic nephropathy (DN) has an increasing global prevalence with excessive health expenditure and burden. Exosomal mRNAs regulate intercellular communications and participate in the pathogenesis of various d...

Authors: Ehsan Hashemi, Hojat Dehghanbanadaki, Alireza Abbasi Baharanchi, Katayoon Forouzanfar, Ardeshir Kakaei, Seyed Mohammad Mohammadi, Saba Zeidi and Farideh Razi

MRI contributes to accurate and early diagnosis of non-radiographic HLA-B27 negative axial spondyloarthritis

Nonradiographic axial spondyloarthropathies (nr-axSpA) are diagnosed by the absence of radiographic sacroiliitis and the presence of bone marrow edema (BME) on magnetic resonance imaging (MRI). According to th...

Authors: Chun-Chi Lu, Guo-Shu Huang, Tony Szu-Hsien Lee, En Chao, Hsiang-Cheng Chen, Yong-Si Guo, Shi-Jye Chu, Feng-Cheng Liu, San-Yuan Kao, Tsung-Yun Hou, Chen-Hung Chen, Deh-Ming Chang and Sin-Yi Lyu

GSTP1 as a novel target in radiation induced lung injury

The glutathione S-transferase P1(GSTP1) is an isoenzyme in the glutathione-S transferases (GSTs) enzyme system, which is the most abundant GSTs expressed in adult lungs. Recent research shows that GSTP1 is clo...

Authors: Xiao Lei, Lehui Du, Wei Yu, Yao Wang, Na Ma and Baolin Qu

Dissecting immune cell stat regulation network reveals biomarkers to predict ICB therapy responders in melanoma

Immunotherapy is a revolutionary strategy in cancer therapy, but the resistance of which is one of the important challenges. Detecting the regulation of immune cells and biomarkers concerning immune checkpoint...

Authors: Jingwen Wang, Feng Li, Yanjun Xu, Xuan Zheng, Chunlong Zhang, Congxue Hu, Yingqi Xu, Wanqi Mi, Xia Li and Yunpeng Zhang

CHN1 promotes epithelial–mesenchymal transition via the Akt/GSK-3β/Snail pathway in cervical carcinoma

Metastasis and invasion are crucial in determining the mortality of cervical carcinoma (CC) patients. The epithelial–mesenchymal transition (EMT) is now a universal explanation for the mechanisms of tumor meta...

Authors: Haoqi Zhao, Lan Wang, Shufang Wang, Xihua Chen, Min Liang, Xin Zhang, Jiedong Wang and Xiangbo Xu

Circ_001209 aggravates diabetic retinal vascular dysfunction through regulating miR-15b-5p/COL12A1

Diabetic retinopathy, a common complication of diabetes mellitus and a major cause of blindness. circRNAs spongs target miRNA and thus influencing mRNA expression in DR. We investigated the mechanism of circ_0...

Authors: Fang Wang and Meixia Zhang

Establishment, validation and evaluation of predictive model for early relapse after R0 resection in hepatocellular carcinoma patients with microvascular invasion

This is the first study to build and evaluate a predictive model for early relapse after R0 resection in hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI).

Authors: Kai Zhang, Changcheng Tao, Tana Siqin, Jianxiong Wu and Weiqi Rong

Chronic obstructive pulmonary disease does not impair responses to resistance training

Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiol...

Authors: Knut Sindre Mølmen, Daniel Hammarström, Gunnar Slettaløkken Falch, Morten Grundtvig, Lise Koll, Marita Hanestadhaugen, Yusuf Khan, Rafi Ahmad, Bente Malerbakken, Tore Jørgen Rødølen, Roger Lien, Bent R. Rønnestad, Truls Raastad and Stian Ellefsen

Heart failure with preserved ejection fraction based on aging and comorbidities

Heart failure (HF) with preserved ejection fraction (HFpEF) is a leading cause of hospitalizations and mortality when diagnosed at the age of ≥ 65 years. HFpEF represents multifactorial and multisystemic syndr...

Authors: Ying Lin, Shihui Fu, Yao Yao, Yulong Li, Yali Zhao and Leiming Luo

HLA-dependent heterogeneity and macrophage immunoproteasome activation during lung COVID-19 disease

The worldwide pandemic caused by the SARS-CoV-2 virus is characterized by significant and unpredictable heterogeneity in symptoms that remains poorly understood.

Authors: Christophe Desterke, Ali G. Turhan, Annelise Bennaceur-Griscelli and Frank Griscelli

Combined IFN-γ and IL-2 release assay for detect active pulmonary tuberculosis: a prospective multicentre diagnostic study in China

We performed a prospective multicentre diagnostic study to evaluate the combined interferon-γ (IFN-γ) and interleukin-2 (IL-2) release assay for detect active pulmonary tuberculosis (TB) in China.

Authors: Yaoju Tan, Yunhong Tan, Junlian Li, Pengnan Hu, Ping Guan, Haobin Kuang, Qide Liang, Yanyan Yu, Zhongnan Chen, Quan Wang, Zhenping Yang, DiLiNaZi AiKeReMu, Yu Pang and Jianxiong Liu

An easy-to-operate web-based calculator for predicting the progression of chronic kidney disease

This study aimed to establish and validate an easy-to-operate novel scoring system based on simple and readily available clinical indices for predicting the progression of chronic kidney disease (CKD).

Authors: Qian Xu, Yunyun Wang, Yiqun Fang, Shanshan Feng, Cuiyun Chen and Yanxia Jiang

ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA

Reversible enzymatic methylation of mammalian mRNA is widespread and serves crucial regulatory functions, but little is known to what degree chemical alkylators mediate overlapping modifications and whether ce...

Authors: Kristian Lied Wollen, Lars Hagen, Cathrine B. Vågbø, Renana Rabe, Tobias S. Iveland, Per Arne Aas, Animesh Sharma, Bjørnar Sporsheim, Hilde O. Erlandsen, Vuk Palibrk, Magnar Bjørås, Davi M. Fonseca, Nima Mosammaparast and Geir Slupphaug

Multi-trajectories of lipid indices with incident cardiovascular disease, heart failure, and all-cause mortality: 23 years follow-up of two US cohort studies

Understanding the distinct patterns (trajectories) of variation in blood lipid levels before diagnosing cardiovascular disease (CVD) might carry important implications for improving disease prevention or treat...

Authors: Fatemeh Koohi, Davood Khalili, Mohammad Ali Mansournia, Farzad Hadaegh and Hamid Soori

Nomogram for short-term outcome assessment in AChR subtype generalized myasthenia gravis

An accurate prediction for prognosis can help in guiding the therapeutic options and optimizing the trial design for generalized myasthenia gravis (gMG). We aimed to develop and validate a predictive nomogram ...

Authors: Rui Zhao, Ying Wang, Xiao Huan, Huahua Zhong, Zhirui Zhou, Jianying Xi, Yuwei Da, Lin Lei, Ting Chang, Zhe Ruan, Lijun Luo, Shengnan Li, Huan Yang, Yi Li, Sushan Luo and Chongbo Zhao

Association between serum advanced oxidation protein products and mortality risk in maintenance hemodialysis patients

The association between serum advanced oxidation protein products (AOPP) and mortality risk remains equivocal. We aimed to assess the correlation of serum AOPP levels with the risk of all-cause mortality in he...

Authors: Chun Zhou, Yuanyuan Zhang, Jianghua Chen, Changlin Mei, Fei Xiong, Wei Shi, Wei Zhou, Xusheng Liu, Shiren Sun, Jianwei Tian, Ziliang Ye, Qimeng Wu, Xianhui Qin, Jianping Jiang and Fan Fan Hou

STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose

Epithelial-mesenchymal transition (EMT) of mesothelial cells is a key step in the peritoneal fibrosis (PF). Recent evidence indicates that signal transducer and activator of transcription 3 (STAT3) might media...

Authors: Xiaoxiao Yang, Manchen Bao, Yi Fang, Xiaofang Yu, Jun Ji and Xiaoqiang Ding

Regarding: “The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: a randomized clinical trial”

Authors: Takeshi Nakata, Takashi Ariie and Shunsuke Taito

Multi-institutional development and external validation of machine learning-based models to predict relapse risk of pancreatic ductal adenocarcinoma after radical resection

Surgical resection is the only potentially curative treatment for pancreatic ductal adenocarcinoma (PDAC) and the survival of patients after radical resection is closely related to relapse. We aimed to develop...

Authors: Xiawei Li, Litao Yang, Zheping Yuan, Jianyao Lou, Yiqun Fan, Aiguang Shi, Junjie Huang, Mingchen Zhao and Yulian Wu

SRPK1/AKT axis promotes oxaliplatin-induced anti-apoptosis via NF-κB activation in colon cancer

Colorectal cancer is the third most common diagnosis. Oxaliplatin is used as first-line treatment of colon cancer. However, oxaliplatin resistance greatly reduces its therapeutic effect. SRPK1 involves in pre-...

Authors: Jing-Qiang Huang, He-Feng Li, Jing Zhu, Jun-Wei Song, Xian-Bin Zhang, Peng Gong, Qiu-Yu Liu, Chun-Hui Zhou, Liang Wang and Li-Yun Gong

Molecular subtype identification and prognosis stratification by a metabolism-related gene expression signature in colorectal cancer

Metabolic reprograming have been associated with cancer occurrence and progression within the tumor immune microenvironment. However, the prognostic potential of metabolism-related genes in colorectal cancer (...

Authors: Dagui Lin, Wenhua Fan, Rongxin Zhang, Enen Zhao, Pansong Li, Wenhao Zhou, Jianhong Peng and Liren Li

Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 3rd–5th, 2020, Italy)

Advances in immune checkpoint therapy and targeted therapy have led to improvement in overall survival for patients with advanced melanoma. Single agent checkpoint PD-1 blockade and combination with BRAF/MEK t...

Authors: Paolo A. Ascierto, Christian Blank, Reinhard Dummer, Marc S. Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Patrick Hwu, Pawel Kalinski, Michelle Krogsgaard, Roger S. Lo, Jason J. Luke, Bart Neyns, Michael A. Postow, Sergio A. Quezada…

Long term prognostic implication of newly detected abnormal glucose tolerance among patients with stable cardiovascular disease: a population-based cohort study

Fasting plasma glucose (FPG) and 2-h post challenge plasma glucose (2 h-PCPG), whether as continuous or categorical variables, are associated with incident cardiovascular disease (CVD) and diabetes; however, t...

Authors: Maryam Kabootari, Samaneh Asgari, Seyedeh Maryam Ghavam, Hengameh Abdi, Fereidoun Azizi and Farzad Hadaegh

A novel surgical model for the preclinical assessment of the osseointegration of dental implants: a surgical protocol and pilot study results

Dental implants are considered the gold standard replacement for missing natural teeth. The successful clinical performance of dental implants is due to their ability to osseointegrate with the surrounding bon...

Authors: Noura M. AlOtaibi, Michael Dunne, Ashraf F. Ayoub and Kurt B. Naudi

The appropriate division of data in training of computers to predict physicians’ decision on blood transfusions: a reply to Dr. Sander de Bruyne

Authors: Yuanyuan Yao, Jenny Cifuentes, Bin Zheng and Min Yan

Large-scale literature mining to assess the relation between anti-cancer drugs and cancer types

There is a huge body of scientific literature describing the relation between tumor types and anti-cancer drugs. The vast amount of scientific literature makes it impossible for researchers and physicians to e...

Authors: Chris Bauer, Ralf Herwig, Matthias Lienhard, Paul Prasse, Tobias Scheffer and Johannes Schuchhardt

Multi-omics analyses of human colorectal cancer revealed three mitochondrial genes potentially associated with poor outcomes of patients

The identification of novel functional biomarkers is essential for recognizing high-risk patients, predicting recurrence, and searching for appropriate treatment. However, no prognostic biomarker has been appl...

Authors: Wei Zhang, Liewen Lin, Ligang Xia, Wanxia Cai, Weier Dai, Chang Zou, Lianghong Yin, Donge Tang, Yong Xu and Yong Dai

Exploratory analysis to identify the best antigen and the best immune biomarkers to study SARS-CoV-2 infection

Recent studies proposed the whole-blood based IFN-γ-release assay to study the antigen-specific SARS-CoV-2 response. Since the early prediction of disease progression could help to assess the optimal treatment...

Authors: Elisa Petruccioli, Saeid Najafi Fard, Assunta Navarra, Linda Petrone, Valentina Vanini, Gilda Cuzzi, Gina Gualano, Luca Pierelli, Antonio Bertoletti, Emanuele Nicastri, Fabrizio Palmieri, Giuseppe Ippolito and Delia Goletti

Dipstick proteinuria and risk of type 2 diabetes mellitus: a nationwide population-based cohort study

Proteinuria has been recognized as a marker of systemic inflammation and endothelial dysfunction associated with insulin resistance and β-cell impairment, which can contribute to the development of type 2 diab...

Authors: Jimin Jeon and Jinkwon Kim

PD-1/PD-L1 checkpoint inhibitors during late stages of life: an ad-hoc analysis from a large multicenter cohort

The favourable safety profile and the increasing confidence with immune checkpoint inhibitors (ICIs) might have boosted their prescription in frail patients with short life expectancies, who usually are not tr...

Authors: Daniele Santini, Tea Zeppola, Marco Russano, Fabrizio Citarella, Cecilia Anesi, Sebastiano Buti, Marco Tucci, Alessandro Russo, Maria Chiara Sergi, Vincenzo Adamo, Luigia S. Stucci, Melissa Bersanelli, Giulia Mazzaschi, Francesco Spagnolo, Francesca Rastelli, Francesca Chiara Giorgi…

TPM, FPKM, or Normalized Counts? A Comparative Study of Quantification Measures for the Analysis of RNA-seq Data from the NCI Patient-Derived Models Repository

In order to correctly decode phenotypic information from RNA-sequencing (RNA-seq) data, careful selection of the RNA-seq quantification measure is critical for inter-sample comparisons and for downstream analy...

Authors: Yingdong Zhao, Ming-Chung Li, Mariam M. Konaté, Li Chen, Biswajit Das, Chris Karlovich, P. Mickey Williams, Yvonne A. Evrard, James H. Doroshow and Lisa M. McShane

The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial

Obstructive sleep apnea (OSA), a sleep disorder frequently observed in individuals living with obesity, consists of repeated involuntary breathing obstructions during sleep, leading to intermittent hypoxia (IH...

Authors: Renée Morin, Jean-François Mauger, Ruwan Amaratunga and Pascal Imbeault

The landscape of biobanks in Poland—characteristics of Polish biobanking units at the beginning of BBMRI.pl organization

Biobanking is an area of scientific activity that is growing in strength and importance. The variety of collections combining biological samples and medical scientific information makes biobanking an indispens...

Authors: Anna Chróścicka, Angelika Paluch, Łukasz Kozera and Małgorzata Lewandowska-Szumieł

Correction to: Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts

An amendment to this paper has been published and can be accessed via the original article.

Authors: Jeonghyeon Moon, Seon-yeong Lee, Jeong Won Choi, A. Ram Lee, Jin Hee Yoo, Su-Jin Moon, Sung-Hwan Park and Mi-La Cho

Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients

Genetically engineered chimeric antigen receptor (CAR) T lymphocytes are promising therapeutic tools for cancer. Four CAR T cell drugs, including tisagenlecleucel (tisa-cel) and axicabtagene-ciloleucel (axi-ce...

Authors: Rafik Haderbache, Walid Warda, Eric Hervouet, Mathieu Neto da Rocha, Rim Trad, Vincent Allain, Clementine Nicod, Catherine Thieblemeont, Nicolas Boissel, Pauline Varlet, Ibrahim Yakoub Agha, Lucie Bouquet, Melanie Guiot, Fabienne Venet, Pierre Sujobert, Xavier Roussel…

Long non-coding RNA MEG3 mediates the miR-149-3p/FOXP3 axis by reducing p53 ubiquitination to exert a suppressive effect on regulatory T cell differentiation and immune escape in esophageal cancer

Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been implicated in the progression of esophageal cancer (EC). However, the specific mechanism of the involvement of MEG3 in EC development in...

Authors: Qi-Rong Xu, Jian Tang, Hong-Ying Liao, Ben-Tong Yu, Xiang-Yuan He, Yu-Zhen Zheng and Sheng Liu

Correction to: M2 macrophage-derived exosomal microRNAs inhibit cell migration and invasion in gliomas through PI3K/AKT/mTOR signaling pathway

An amendment to this paper has been published and can be accessed via the original article.

Authors: Jie Yao, Zefen Wang, Yong Cheng, Chao Ma, Yahua Zhong, Yilei Xiao, Xu Gao and Zhiqiang Li

Manifestations of HbSE sickle cell disease: a systematic review

Sickle cell disease (SCD) is commonly encountered in Africa and Middle Eastern countries. The causative mutation in the gene encoding the hemoglobin subunit β (HBB) leads to various genotypic variants of the d...

Authors: Ibrahim Khamees, Fateen Ata, Hassan Choudry, Ashraf T. Soliman, Vincenzo De Sanctis and Mohamed A. Yassin

Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis

Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has been implicated in immunoglobulin (Ig)E activation of mast cells (MCs) via high-affinity I...

Authors: Hui-Na Wang, Kunmei Ji, Li-Na Zhang, Chu-Chu Xie, Wei-Yong Li, Zhen-Fu Zhao and Jia-Jie Chen

Childbearing vs. clinical trial participation: is it one or the other?

Recent advances have shed light on the importance of early therapeutic intervention for neurodegenerative diseases. Primary prevention trials present a potential disease-modifying strategy for pre-symptomatic ...

Authors: Sarah J. Hernandez and Lindsay A. Hohsfield

The negative relationship between patients with NSCLC harbored STK11/KEAP1 copy number variation and immune microenvironment infiltration

Authors: Chenyue Zhang

HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation

Asthma is a frequently occurring respiratory disease with an increasing incidence around the world. Airway inflammation and remodeling are important contributors to the occurrence of asthma. We conducted this ...

Authors: Wendi Wei, Weida Chen and Naifeng He

Extrachromosomal circular DNA: a new potential role in cancer progression

Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular...

Authors: Tianyi Wang, Haijian Zhang, Youlang Zhou and Jiahai Shi

Radiomic signature of the FOWARC trial predicts pathological response to neoadjuvant treatment in rectal cancer

We aimed to develop a radiomic model based on pre-treatment computed tomography (CT) to predict the pathological complete response (pCR) in patients with rectal cancer after neoadjuvant treatment and tried to ...

Authors: Zhuokai Zhuang, Zongchao Liu, Juan Li, Xiaolin Wang, Peiyi Xie, Fei Xiong, Jiancong Hu, Xiaochun Meng, Meijin Huang, Yanhong Deng, Ping Lan, Huichuan Yu and Yanxin Luo

Immune radiobiology

Authors: Claire Vanpouille-Box

Cellular and molecular mediators of lymphangiogenesis in inflammatory bowel disease

Recent studies reporting the intricate crosstalk between cellular and molecular mediators and the lymphatic endothelium in the development of inflammatory bowel diseases (IBD) suggest altered inflammatory cell...

Authors: Dickson Kofi Wiredu Ocansey, Bing Pei, Xinwei Xu, Lu Zhang, Chinasa Valerie Olovo and Fei Mao

Increased risk of pulmonary and extrapulmonary tuberculosis infection in patients with polycystic kidney disease: a nationwide population-based study with propensity score-matching analysis

Polycystic kidney disease (PKD) is a common renal disorder affecting approximately 1 in 1000 live births. Tuberculosis (TB) is an infectious disease worldwide. This study investigated the risk of TB infection ...

Authors: Ting-Fang Chiu, Tung-Min Yu, Chih-Wei Chiu, Brian K. Lee, Tsuo-Hung Lan, Chi-Yuan Li, Mei-Chen Lin and Chia-Hung Kao