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  1. The term eGene has been applied to define a gene whose expression level is affected by at least one independent expression quantitative trait locus (eQTL). It is both theoretically and empirically important to...

    Authors: Shuo Zhang, Zhou Jiang and Ping Zeng
    Citation: Journal of Translational Medicine 2024 22:258
  2. Although hepatitis B virus (HBV) infection is a major risk factor for hepatic cancer, the majority of HBV carriers do not develop this lethal disease. Additional molecular alterations are thus implicated in th...

    Authors: Fuqiang Huang, Jing Guo, Na Zhao, Mengjie Hou, Xiaochen Gai, Shuhui Yang, Pei Cai, Yanan Wang, Qian Ma, Qi Zhao, Li Li, Huayu Yang, Yanling Jing, Di Jin, Zhongdong Hu, Xiaojun Zha…
    Citation: Journal of Translational Medicine 2024 22:254
  3. Tobacco pollutants are prevalent in the environment, leading to inadvertent exposure of pregnant females. Studies of these pollutants' toxic effects on embryonic development have not fully elucidated the poten...

    Authors: Jiasheng Chen, Yuxin Lin, Deyi Gen, Wanxian Chen, Rui Han, Hao Li, Shijie Tang, Shukai Zheng and Xiaoping Zhong
    Citation: Journal of Translational Medicine 2024 22:253
  4. Albuminuria, the presence of excess of protein in urine, is a well-known risk factor for early kidney damage among diabetic/prediabetic patients. There is a complex interaction between physical activity (PA) a...

    Authors: Bingquan Xiong, Yufan Wang, Juan He, Lisha Wang, Rui He, Min Zhu, Jiaxing Wang, Yingrui Li, Bin Liu, Kaihu Xiao and Qiang She
    Citation: Journal of Translational Medicine 2024 22:252
  5. Circular RNAs (circRNAs) have been proved to play crucial roles in the development of various cancers. However, the molecular mechanism of circGLIS3 involved in gastric cancer (GC) tumorigenesis has not been e...

    Authors: Yongxin Zhang, Xiaofeng Wang, Wenwei Liu, Tianxiang Lei, Tang Qiao, Wei Feng and Wu Song
    Citation: Journal of Translational Medicine 2024 22:251
  6. Intratumoral injection of oncolytic viruses (OVs) shows promise in immunotherapy: ONCOS-102, a genetically engineered OV that encodes Granulocyte–Macrophage Colony-Stimulating Factor (GM-CSF) demonstrated effi...

    Authors: Neshat Saffarzadeh, Emelie Foord, Eoghan O’Leary, Rand Mahmoun, Thomas Birkballe Hansen, Victor Levitsky, Thomas Poiret and Michael Uhlin
    Citation: Journal of Translational Medicine 2024 22:250
  7. Bioactive lipids involved in the progression of various diseases. Nevertheless, there is still a lack of biomarkers and relative regulatory targets. The lipidomic analysis of the samples from platinum-resistan...

    Authors: Menglin Chen, Cancan Zhang, Huaizhi Li, Shanshan Zheng, Yaqi Li, Mengyun Yuan, Yuxuan Chen, Jian Wu and Qingmin Sun
    Citation: Journal of Translational Medicine 2024 22:249
  8. Acute ischemic stroke is a common neurological disease with a significant financial burden but lacks effective drugs. Hypoxia-inducible factor (HIF) and prolyl hydroxylases (PHDs) participate in the pathophysi...

    Authors: Jian Xie, Yuan Zhang, Bin Li, Wen Xi, Yu Wang, Lu Li, Chenchen Liu, Ling Shen, Bing Han, Yan Kong, HongHong Yao and Zhijun Zhang
    Citation: Journal of Translational Medicine 2024 22:248
  9. Currently, noninvasive imaging techniques and circulating biomarkers are still insufficient to accurately assess carotid plaque stability, and an in-depth understanding of the molecular mechanisms that contrib...

    Authors: Zhichao Lai, Chaonan Wang, Xiaoyan Liu, Haidan Sun, Zhengguang Guo, Jiang Shao, Kang Li, Junye Chen, Jiaxian Wang, Xiangling Lei, Keqiang Shu, Yuyao Feng, Deqiang Kong, Wei Sun and Bao Liu
    Citation: Journal of Translational Medicine 2024 22:247
  10. Thrombo-inflammation and neutrophil extracellular traps (NETs) are exacerbated in severe cases of COVID-19, potentially contributing to disease exacerbation. However, the mechanisms underpinning this dysregula...

    Authors: Geoffrey Garcia, Sylvie Labrouche-Colomer, Alexandre Duvignaud, Etienne Clequin, Charles Dussiau, David-Alexandre Trégouët, Denis Malvy, Renaud Prevel, Atika Zouine, Isabelle Pellegrin, Julien Goret, Maria Mamani-Matsuda, Antoine Dewitte and Chloe James
    Citation: Journal of Translational Medicine 2024 22:246
  11. In diabetic retinopathy (DR), hypoxia-inducible factor (HIF-1α) induces oxidative stress by upregulating glycolysis. This process leads to neurodegeneration, particularly photoreceptor cell damage, which furth...

    Authors: Bolin Chen, Jing Zou, Lihui Xie, Yinjun Cai, Bowen Li, Wei Tan, Jinhaohao Huang, Fangling Li and Huizhuo Xu
    Citation: Journal of Translational Medicine 2024 22:245
  12. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for hematological malignancies. However, viral infections, particularly EBV infection, frequently occur following allo-H...

    Authors: Xun-Hong Cao, Ze-Ying Fan, Ying-Jun Chang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang and Xiang-Yu Zhao
    Citation: Journal of Translational Medicine 2024 22:244
  13. Peritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis.

    Authors: Qiong Song, Pengbo Wang, Huan Wang, Meijing Pan, Xiujuan Li, Zhuan’e Yao, Wei Wang, Guangbo Tang and Sen Zhou
    Citation: Journal of Translational Medicine 2024 22:243
  14. Immune Checkpoint Inhibitors (ICIs) lead to durable response and a significant increase in long-term survival in patients with advanced malignant melanoma (MM) and Non-Small Cell Lung Cancer (NSCLC). The ident...

    Authors: Giulia Pasello, Aline S. C. Fabricio, Paola Del Bianco, Valentina Salizzato, Adolfo Favaretto, Luisa Piccin, Fable Zustovich, Alessio Fabozzi, Costanza De Rossi, Jacopo Pigozzo, Mattia De Nuzzo, Elia Cappelletto, Laura Bonanno, Dario Palleschi, Gian Luca De Salvo, Valentina Guarneri…
    Citation: Journal of Translational Medicine 2024 22:242
  15. Tumor regression following immune checkpoint blockade (ICB) is often associated with immune-related adverse events (irAEs), marked by inflammation in non-cancerous tissues. This study was undertaken to investi...

    Authors: Shuming Chen, Tracee L. McMiller, Abha Soni, Farah Succaria, John-William Sidhom, Laura C. Cappelli, Livia A. Casciola-Rosen, Isaac R. Morales, Preethi Sankaran, Alan E. Berger, Julie Stein Deutsch, Qingfeng C. Zhu, Robert A. Anders, Jody E. Hooper, Drew M. Pardoll, Evan J. Lipson…
    Citation: Journal of Translational Medicine 2024 22:241
  16. Mitochondria produce adenosine triphosphate through respiratory activities to power sperm differentiation and motility, and decreased mitochondrial respiratory activity can result in poor sperm motility and as...

    Authors: Yining Liu, Tongtong Li, Mingze Shi, Yanling Wan, Hanzhen Li, Mingyu Zhang, Ziqi Wang, Shiyu Wang, Yue Lv, Gang Lu, Hongbin Liu, Haobo Zhang and Tao Huang
    Citation: Journal of Translational Medicine 2024 22:240
  17. The spatial localisation of immune cells within tumours are key to understand the intercellular communications that can dictate clinical outcomes. Here, we demonstrate an analysis pipeline for highly multiplex...

    Authors: James Monkman, Afshin Moradi, Joseph Yunis, Geoff Ivison, Aaron Mayer, Rahul Ladwa, Ken O’Byrne and Arutha Kulasinghe
    Citation: Journal of Translational Medicine 2024 22:239
  18. Intratumoral bacteria might play essential roles in tumorigenesis in different cancer types. However, its features and potential roles in hepatocellular carcinoma (HCC) are largely unknown.

    Authors: Chen Xue, Xinyu Gu, Qingmiao Shi, Xiao Ma, Junjun Jia, Yuanshuai Su, Zhengyi Bao, Juan Lu and Lanjuan Li
    Citation: Journal of Translational Medicine 2024 22:237
  19. Spontaneous intracerebral hemorrhage (sICH) is associated with significant mortality and morbidity. Predicting the prognosis of patients with sICH remains an important issue, which significantly affects treatm...

    Authors: Zhi Geng, Chaoyi Yang, Ziye Zhao, Yibing Yan, Tao Guo, Chaofan Liu, Aimei Wu, Xingqi Wu, Ling Wei, Yanghua Tian, Panpan Hu and Kai Wang
    Citation: Journal of Translational Medicine 2024 22:236
  20. Psoriasis is a chronic inflammatory disorder characterized by pathogenic hyperproliferation of keratinocytes and immune dysregulation. Currently, objective evaluation tools reflecting the severity of psoriasis...

    Authors: Young Joon Park, Dong Chan Kim, Soo-Jin Lee, Han Seul Kim, Ji Young Pak, Junho Kim, Jae Youn Cheong and Eun-So Lee
    Citation: Journal of Translational Medicine 2024 22:235
  21. The study of resistance-causing mutations in oncogene-driven tumors is fundamental to guide clinical decisions. Several point mutations affecting the ROS1 kinase domain have been identified in the clinical set...

    Authors: Marc Terrones, Christophe Deben, Felicia Rodrigues-Fortes, Anne Schepers, Ken Op de Beeck, Guy Van Camp and Geert Vandeweyer
    Citation: Journal of Translational Medicine 2024 22:234
  22. Accurate and efficient cell grouping is essential for analyzing single-cell transcriptome sequencing (scRNA-seq) data. However, the existing clustering techniques often struggle to provide timely and accurate ...

    Authors: Jun Ren, Xuejing Lyu, Jintao Guo, Xiaodong Shi, Ying Zhou and Qiyuan Li
    Citation: Journal of Translational Medicine 2024 22:233
  23. Mitochondrial transplantation (MTx) has emerged as a novel therapeutic strategy, particularly effective in diseases characterized by mitochondrial dysfunction. This review synthesizes current knowledge on MTx,...

    Authors: Tomoaki Aoki, Yusuke Endo, Eriko Nakamura, Cyrus E. Kuschner, Jacob Kazmi, Parmeshar Singh, Tai Yin, Lance B. Becker and Kei Hayashida
    Citation: Journal of Translational Medicine 2024 22:230
  24. Natural killer (NK) cells are unique from other immune cells in that they can rapidly kill multiple neighboring cells without the need for antigenic pre-sensitization once the cells display surface markers ass...

    Authors: Linxuan Miao, Chenglin Lu, Bin Zhang, Huili Li, Xu Zhao, Haoran Chen, Ying Liu and Xiaonan Cui
    Citation: Journal of Translational Medicine 2024 22:229
  25. Retinal degenerative disorders (RDDs) cause vision loss by damaging retinal neurons and photoreceptors, affecting individuals of all ages. Cell-based therapy has emerged as an effective approach for the treatm...

    Authors: Alireza Soltani Khaboushan, Negar Ebadpour, Mohammad Mehdi Johari Moghadam, Zahra Rezaee, Abdol-Mohammad Kajbafzadeh and Masoumeh Majidi Zolbin
    Citation: Journal of Translational Medicine 2024 22:227
  26. Breast Cancer (BC) is a highly heterogeneous and complex disease. Personalized treatment options require the integration of multi-omic data and consideration of phenotypic variability. Radiogenomics aims to me...

    Authors: Zi Huai Huang, Lianghong Chen, Yan Sun, Qian Liu and Pingzhao Hu
    Citation: Journal of Translational Medicine 2024 22:226
  27. Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, emerging as a significant health issue on a global scale. Berberine exhibits potential for treating NAFLD, but clinical e...

    Authors: Qilong Nie, Mingyang Li, Caiyang Huang, Yongwei Yuan, Qiuyan Liang, Xiaojun Ma, Tengyu Qiu and Jianhong Li
    Citation: Journal of Translational Medicine 2024 22:225
  28. In recent years, natural bone extracellular matrix (ECM)-inspired materials have found widespread application as scaffolds for bone tissue engineering. However, the challenge of creating scaffolds that mimic n...

    Authors: Yanqing Yang, Huan He, Fang Miao, Mingwei Yu, Xixi Wu, Yuanhang Liu, Jie Fu, Junwei Chen, Liya Ma, Xiangru Chen, Ximing Peng, Zhen You and Chuchao Zhou
    Citation: Journal of Translational Medicine 2024 22:224
  29. Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor, that is refractory to standard treatment and to immunotherapy with immune-checkpoint inhibitors (ICI). Noteworthy, melanoma brain metas...

    Authors: Maria Fortunata Lofiego, Francesca Piazzini, Francesca Pia Caruso, Francesco Marzani, Laura Solmonese, Emma Bello, Fabrizio Celesti, Maria Claudia Costa, Teresa Noviello, Roberta Mortarini, Andrea Anichini, Michele Ceccarelli, Sandra Coral, Anna Maria Di Giacomo, Michele Maio and Alessia Covre
    Citation: Journal of Translational Medicine 2024 22:223
  30. Colonoscopy is a classic diagnostic method with possible complications including abdominal pain and diarrhoea. In this study, gut microbiota dynamics and related metabolic products during and after colonoscopy...

    Authors: Zhenhui Chen, Lu Yu, Jiaxin Liu, Jingjing Kong, Xiaoshi Deng, Xiaotong Guo, Jiamin Shan, Daixuan Zhou, Wendan Li, Yangfan Lin, Wanwen Huang, Weisen Zeng, Xinlong Shi, Yang Bai and Hongying Fan
    Citation: Journal of Translational Medicine 2024 22:222
  31. Cellular stress associated with static-cold storage (SCS) and warm reperfusion of donor lungs can contribute to ischemia–reperfusion (IR) injury during transplantation. Adding cytoprotective agents to the pres...

    Authors: Dejan Bojic, Tanroop Aujla, Junichi Sugihara, Aaron Wong, Shaf Keshavjee and Mingyao Liu
    Citation: Journal of Translational Medicine 2024 22:221
  32. Targeting CD47/SIRPα axis has emerged as a promising strategy in cancer immunotherapy. Despite the encouraging clinical efficacy observed in hematologic malignancies through CD47-SIRPα blockade, there are safe...

    Authors: Tao Wang, Si-Qin Wang, Yin-Xiao Du, Dan-Dan Sun, Chang Liu, Shuang Liu, Ying-Ying Sun, Hai-Long Wang, Chun-Sheng Zhang, Hai-Long Liu, Lei Jin and Xiao-Ping Chen
    Citation: Journal of Translational Medicine 2024 22:220
  33. The rapid emergence and global dissemination of the Omicron variant of SARS-CoV-2 have posed formidable challenges in public health. This scenario underscores the urgent need for an enhanced understanding of O...

    Authors: Qianyue Yang, Zhiwei Lin, Mingshan Xue, Yueting Jiang, Libing Chen, Jiahong Chen, Yuhong Liao, Jiali Lv, Baojun Guo, Peiyan Zheng, Huimin Huang and Baoqing Sun
    Citation: Journal of Translational Medicine 2024 22:219
  34. Infectious pancreatic necrosis (IPN) is a serious complication of acute pancreatitis, and early recognition and timely intervention are the keys to improving clinical outcomes. The purpose of this study was to...

    Authors: Xiangping Huang, Ling Wu, Qianhui Ouyang, Ying Huang, Lanhui Hong, Sixiang Liu, Kongzhi Yang, Ding Ning and Chao Chao Tan
    Citation: Journal of Translational Medicine 2024 22:218
  35. Lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer, but the early diagnosis rate is low. The RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in several cancers but its mec...

    Authors: Zelai He, Huijun Zhang, Haibo Xiao, Xiangyu Zhang, Hongbo Xu, Ruifen Sun and Siwen Li
    Citation: Journal of Translational Medicine 2024 22:216
  36. Cardiovascular diseases (CVDs) are the leading cause of death around the world. Most CVDs-related death can be prevented by the optimal management of risk factors such as unhealthy diet and physical inactivity...

    Authors: Yun Qian, Jing-Yu (Benjamin) Tan, Tao Wang, Daniel Bressington, Hong-Juan Zhou, Meng-Yuan Li and Xian-Liang Liu
    Citation: Journal of Translational Medicine 2024 22:215
  37. Primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) variant syndrome (VS) exhibit a complex overlap of AIH features with PBC, leading to poorer prognoses than those with PBC or AIH alone. The biom...

    Authors: Fan Yang, Leyu Zhou, Yi Shen, Xianglin Wang, Xiaoli Fan and Li Yang
    Citation: Journal of Translational Medicine 2024 22:214
  38. First identified in Drosophila melanogaster, the Hippo pathway is considered a major regulatory cascade controlling tissue homeostasis and organ development. Hippo signaling components include kinases whose activ...

    Authors: Giulia Schiavoni, Beatrice Messina, Stefano Scalera, Lorenzo Memeo, Cristina Colarossi, Marzia Mare, Giovanni Blandino, Gennaro Ciliberto, Giulia Bon and Marcello Maugeri-Saccà
    Citation: Journal of Translational Medicine 2024 22:213
  39. Clear cell renal cell carcinoma (ccRCC) is known for abnormal lipid metabolism and widespread activation of HIF-2α. Recently, the importance of autophagy in ccRCC has been focused, and it has potential connect...

    Authors: Yu Huang, Zhiyong Xiong, Jianjun Wang, Yafen Gao, Qi Cao, Decai Wang, Jian Shi, Zhixian Chen and Xiong Yang
    Citation: Journal of Translational Medicine 2024 22:212
  40. Lactylation, a novel contributor to post-translational protein modifications, exhibits dysregulation across various tumors. Nevertheless, its intricate involvement in colorectal carcinoma, particularly for non...

    Authors: Huixia Huang, Keji Chen, Yifei Zhu, Zijuan Hu, Yaxian Wang, Jiayu Chen, Yuxue Li, Dawei Li and Ping Wei
    Citation: Journal of Translational Medicine 2024 22:211
  41. Clear cell renal cell carcinoma is a prototypical tumor characterized by metabolic reprogramming, which extends beyond tumor cells to encompass diverse cell types within the tumor microenvironment. Nonetheless...

    Authors: Guanwen Yang, Jiangting Cheng, Jiayi Xu, Chenyang Shen, Xuwei Lu, Chang He, Jiaqi Huang, Minke He, Jie Cheng and Hang Wang
    Citation: Journal of Translational Medicine 2024 22:210
  42. Human discs large-associated protein 5 (DLGAP5) is reported to play a pivotal role in regulating the cell cycle and implicate in tumorigenesis and progression of various cancers. Our current research endeavore...

    Authors: Maojian Chen, Shaoping Zhang, Fan Wang, Junyi He, Wei Jiang and Li Zhang
    Citation: Journal of Translational Medicine 2024 22:209
  43. Mitochondrial alterations, often dependent on unbalanced mitochondrial dynamics, feature in the pathobiology of human cancers, including multiple myeloma (MM). Flavanones are natural flavonoids endowed with mi...

    Authors: Roberta Torcasio, Maria Eugenia Gallo Cantafio, Claudia Veneziano, Carmela De Marco, Ludovica Ganino, Ilenia Valentino, Maria Antonietta Occhiuzzi, Ida Daniela Perrotta, Teresa Mancuso, Filomena Conforti, Bruno Rizzuti, Enrica Antonia Martino, Massimo Gentile, Antonino Neri, Giuseppe Viglietto, Fedora Grande…
    Citation: Journal of Translational Medicine 2024 22:208
  44. The global cellular landscape of the tumor microenvironment (TME) combining primary and metastatic liver tumors has not been comprehensively characterized.

    Authors: Menghui Gui, Shilin Huang, Shizhou Li, Yuying Chen, Furong Cheng, Yulin Liu, Ji-ao Wang, Yuting Wang, Rui Guo, Yiming Lu, Pengbo Cao and Gangqiao Zhou
    Citation: Journal of Translational Medicine 2024 22:206

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