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  1. Content type: Research

    SWATH-MS has emerged as the strategy of choice for biomarker discovery due to the proteome coverage achieved in acquisition and provision to re-interrogate the data. However, in quantitative analysis using SWA...

    Authors: Mythreyi Narasimhan, Sadhana Kannan, Aakash Chawade, Atanu Bhattacharjee and Rukmini Govekar

    Citation: Journal of Translational Medicine 2019 17:184

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  2. Content type: Research

    Due to recurrent hypoxia-reperfusion injury induced by vaso-occlusive crises (VOC), patients with sickle cell disease (SCD) may have intestinal injury and increased permeability. These may explain the qualitat...

    Authors: Dibyendu Dutta, Barbara Methe, Salomon Amar, Alison Morris and Seah H. Lim

    Citation: Journal of Translational Medicine 2019 17:183

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  3. Content type: Research

    Melanoma is an aggressive type of skin cancer whose aetiology remains elusive as both environmental and genetic factors can contribute to its development. Recent studies have demonstrated the existence of mult...

    Authors: Maria Santa Rocca, Clara Benna, Simone Mocellin, Carlo Riccardo Rossi, Aichi Msaki, Andrea Di Nisio, Giuseppe Opocher and Carlo Foresta

    Citation: Journal of Translational Medicine 2019 17:181

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  4. Content type: Research

    ST-segment elevation myocardial infarction (STEMI) displays circadian variability with the highest incidence in the morning hours. Data on whether the time-of-day at symptom onset affects infarct size or patie...

    Authors: Hendrik B. Sager, Oliver Husser, Sabine Steffens, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati, Gjin Ndrepepa and Thorsten Kessler

    Citation: Journal of Translational Medicine 2019 17:180

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  5. Content type: Research

    Glioblastomas have a high degree of malignancy, high recurrence rate, high mortality rate, and low cure rate. Searching for new markers of glioblastomas is of great significance for improving the diagnosis, pr...

    Authors: Siqi Wang, Fang Liu, Yuhui Wang, Wenliang Fan, Hongyang Zhao, Liying Liu, Chunyuan Cen, Xiaobin Jiang, Min Sun and Ping Han

    Citation: Journal of Translational Medicine 2019 17:179

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  7. Content type: Research

    Kidney renal clear cell carcinoma (KIRC) is the most common type of kidney cancer in adults, and it is responsible for approximately 90–95% of cases. Although extensive evidence has suggested that many immune-...

    Authors: Enyang Zhao, Lihong Li, Wenfu Zhang, Wanhui Wang, Yunhui Chan, Bosen You and Xuedong Li

    Citation: Journal of Translational Medicine 2019 17:177

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  8. Content type: Research

    Lifestyle intervention may have a critical effect on the association between genetics and obesity. This study aimed to investigate changes in FTO and IRX3 gene expression in obese and overweight male adolescents ...

    Authors: Saeid Doaei, Naser Kalantari, Pantea Izadi, Tuire Salonurmi, Alireza Mosavi Jarrahi, Shahram Rafieifar, Ghasem Azizi Tabesh, Ghazaleh Rahimzadeh, Maryam Gholamalizadeh and Mark O. Goodarzi

    Citation: Journal of Translational Medicine 2019 17:176

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  9. Content type: Research

    In non-human primates (NHPs) and humans, partial protection from HIV/SIV infection or suppression of replication is achievable by Env-binding antibodies and Gag-specific CD8+ T-cells targeting protective epito...

    Authors: Melanie Schwerdtfeger, Anne-Marie Carola Andersson, Lasse Neukirch and Peter Johannes Holst

    Citation: Journal of Translational Medicine 2019 17:175

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  10. Content type: Research

    Patients with X-linked agammaglobulinemia (XLA) are protected against invasive bacterial infections due to IgG replacement therapy, but are still at higher risk for mucosal infections of the gut and respirator...

    Authors: Jeroen D. Langereis, Joannes F. M. Jacobs, Marien I. de Jonge and Marcel van Deuren

    Citation: Journal of Translational Medicine 2019 17:174

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  11. Content type: Research

    Prostate cancer is an extremely heterogeneous disease. Despite being clinically similar, some tumours are more likely to recur after surgery compared to others. Distinguishing those that need adjuvant or salva...

    Authors: C. Hoey, M. Ahmed, A. Fotouhi Ghiam, D. Vesprini, X. Huang, K. Commisso, A. Commisso, J. Ray, E. Fokas, D. A. Loblaw, H. H. He and S. K. Liu

    Citation: Journal of Translational Medicine 2019 17:173

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  12. Content type: Review

    The aim of the present review is to discuss how the promising field of biobanking can support health care research strategies. As the concept has evolved over time, biobanks have grown from simple biological s...

    Authors: Luigi Coppola, Alessandra Cianflone, Anna Maria Grimaldi, Mariarosaria Incoronato, Paolo Bevilacqua, Francesco Messina, Simona Baselice, Andrea Soricelli, Peppino Mirabelli and Marco Salvatore

    Citation: Journal of Translational Medicine 2019 17:172

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  13. Content type: Research

    Predicting adverse drug reactions (ADRs) has become very important owing to the huge global health burden and failure of drugs. This indicates a need for prior prediction of probable ADRs in preclinical stages...

    Authors: Salma Jamal, Waseem Ali, Priya Nagpal, Sonam Grover and Abhinav Grover

    Citation: Journal of Translational Medicine 2019 17:171

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  14. Content type: Research

    Amyotrophic lateral sclerosis (ALS) is a debilitating disease with few treatment options. Progress towards new therapies requires validated disease biomarkers, but there is no consensus on which fluid-based me...

    Authors: William R. Swindell, Colin P. S. Kruse, Edward O. List, Darlene E. Berryman and John J. Kopchick

    Citation: Journal of Translational Medicine 2019 17:170

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  15. Content type: Review

    Obesity must be considered a real pathology. In the world wide, obesity represent one of the major public health issue associated with increased morbidity and mortality. Overweight or obesity, in fact, signifi...

    Authors: Antonino De Lorenzo, Santo Gratteri, Paola Gualtieri, Andrea Cammarano, Pierfrancesco Bertucci and Laura Di Renzo

    Citation: Journal of Translational Medicine 2019 17:169

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  16. Content type: Research

    Helios is important for functional and phenotype stability of regulatory T cells (Tregs). However, the role of Helios in autoimmune diseases and its regulation remains unclear. This study aimed to investigate ...

    Authors: Yi Li, Shumei Yang, Zhibin Li, Huanyu Meng, Wanling Jin, Huan Yang and Weifan Yin

    Citation: Journal of Translational Medicine 2019 17:168

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  17. Content type: Research

    In human immunodeficiency virus (HIV) infection, 10–15% of individuals exhibit a rapid decline in CD4+ T cells and become rapid progressors (RPs). Overall, understanding the factors affecting rapid disease pro...

    Authors: Ying Pan, Zi-Ning Zhang, Lin-Bo Yin, Ya-Jing Fu, Yong-Jun Jiang and Hong Shang

    Citation: Journal of Translational Medicine 2019 17:167

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  18. Content type: Research

    Acute myeloid leukemia (AML) is a heterogeneous disease in terms of genetic basis, clinical, biological and prognostic, and is a malignant clonal disease of leukemia stem cells (LSCs). Nearly half of adult AML...

    Authors: Ying Song, Weilong Zhang, Xue He, Xiaoni Liu, Ping Yang, Jing Wang, Kai Hu, Weiyou Liu, Xiuru Zhang, Hongmei Jing and Xiaoliang Yuan

    Citation: Journal of Translational Medicine 2019 17:166

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  19. Content type: Research

    Impairment of natural killer (NK) cell activity is an important mechanism of tumor immunoevasion. T cell immunoglobulin domain and mucin domain-3 (Tim-3) is an activation-induced inhibitory molecule, inducing ...

    Authors: Yujia Zheng, Yu Li, Jingyao Lian, Huiyun Yang, Feng Li, Song Zhao, Yu Qi, Yi Zhang and Lan Huang

    Citation: Journal of Translational Medicine 2019 17:165

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  20. Content type: Research

    Compared with clinically functioning pituitary adenoma (FPA), clinically non-functioning pituitary adenoma (NFPA) lacks of detectable hypersecreting serum hormones and related symptoms which make it difficult ...

    Authors: Sen Cheng, Jiaqi Wu, Chuzhong Li, Yangfang Li, Chunhui Liu, Guilin Li, Wuju Li, Shuofeng Hu, Xiaomin Ying and Yazhuo Zhang

    Citation: Journal of Translational Medicine 2019 17:164

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  21. Content type: Research

    There is an urgent need for novel and effective treatment options for acute myeloid leukemia (AML). Triptolide, a diterpenoid tri-epoxide compound isolated from the herb Tripterygium wilfordii and its water-solub...

    Authors: Bhuwan Giri, Vineet K. Gupta, Brianna Yaffe, Shrey Modi, Pooja Roy, Vrishketan Sethi, Shweta P. Lavania, Selwyn M. Vickers, Vikas Dudeja, Sulagna Banerjee, Justin Watts and Ashok Saluja

    Citation: Journal of Translational Medicine 2019 17:163

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  22. Content type: Research

    The morbidity and mortality of patients with critical illnesses remain high in pulmonary critical care units and a poorly understood correlation between alterations of lipid elements and clinical phenomes rema...

    Authors: Danyan Gao, Linlin Zhang, Dongli Song, Jiapei Lv, Linyan Wang, Shuang Zhou, Yanjun Li, Tao Zeng, Yiming Zeng, Jiaqiang Zhang and Xiangdong Wang

    Citation: Journal of Translational Medicine 2019 17:162

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  23. Content type: Research

    The roles played by cholesterol in cancer development and progression represent a popular field in the cancer community. High cholesterol levels are positively correlated with the risk of various types of canc...

    Authors: Tao Zhang, Qilong Wang, Yeqi Wang, Junping Wang, Yongping Su, Fengchao Wang and Guixue Wang

    Citation: Journal of Translational Medicine 2019 17:161

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  24. Content type: Research

    Flow diverter devices are increasingly used for endovascular treatment of internal carotid artery aneurysms. Treatment of ophthalmic segment aneurysms with flow diverter devices also includes coverage of the o...

    Authors: Xinzhi Wu, Zhongbin Tian, Jian Liu, Wenqiang Li, Junfan Chen, Yangyang Zhou, Xinjian Yang and Shiqing Mu

    Citation: Journal of Translational Medicine 2019 17:160

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  25. Content type: Research

    The tumor-associated microenvironment plays important roles in tumor progression and drug resistance. However, systematic investigations of macrophage–tumor cell interactions to identify novel macrophage-relat...

    Authors: Xiaoqiang Sun, Xiaoping Liu, Mengxue Xia, Yongzhao Shao and Xiaohua Douglas Zhang

    Citation: Journal of Translational Medicine 2019 17:159

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  26. Content type: Research

    Telocytes play key roles in maintenance of organ/tissue function and prevention of organ injury. However, there are great challenges to investigate telocytes functions using primary telocytes, due to the diffi...

    Authors: Dongli Song, Menglin Xu, Ruixue Qi, Ruihua Ma, Yile Zhou, Duojiao Wu, Hao Fang and Xiangdong Wang

    Citation: Journal of Translational Medicine 2019 17:158

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  27. Content type: Research

    Q fever fatigue syndrome (QFS) is a well-documented state of prolonged fatigue following around 20% of acute Q fever infections. It has been hypothesized that low grade inflammation plays a role in its aetiolo...

    Authors: Ruud P. H. Raijmakers, Anne F. M. Jansen, Stephan P. Keijmel, Rob ter Horst, Megan E. Roerink, Boris Novakovic, Leo A. B. Joosten, Jos W. M. van der Meer, Mihai G. Netea and Chantal P. Bleeker-Rovers

    Citation: Journal of Translational Medicine 2019 17:157

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  28. Content type: Research

    New and emerging transfusion–transmitted infections remain a threat to the blood supply. Blood donors are currently screened for less than half of known agents, primarily by individual tests. A screening platf...

    Authors: Valeria De Giorgi, Huizhi Zhou, Harvey J. Alter and Robert D. Allison

    Citation: Journal of Translational Medicine 2019 17:156

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  29. Content type: Research

    Translational medicine (TM) is an emerging domain that aims to facilitate medical or biological advances efficiently from the scientist to the clinician. Central to the TM vision is to narrow the gap between b...

    Authors: Laura Bravo-Merodio, John A. Williams, Georgios V. Gkoutos and Animesh Acharjee

    Citation: Journal of Translational Medicine 2019 17:155

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  30. Content type: Research

    The onset of chronic fatigue syndrome (CFS) has been shown to be associated with several immunological conditions such as infections or atopy. The aim of this study was to clarify the risk of chronic fatigue s...

    Authors: Shin-Yi Tsai, Hsuan-Ju Chen, Chi Chen, Chon-Fu Lio, Chien-Feng Kuo, Kam-Hang Leong, Yu-Ting Tina Wang, Tse-Yen Yang, Ching-Hui You and Wei-Sheng Wang

    Citation: Journal of Translational Medicine 2019 17:154

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  31. Content type: Research

    MicroRNA (miRNA) mediate post-transcriptional gene repression and are involved in a variety of human diseases, including cancer. Soft tissue sarcomas are rare malignancies with a variety of histological subtyp...

    Authors: Clara Benna, Senthilkumar Rajendran, Marco Rastrelli and Simone Mocellin

    Citation: Journal of Translational Medicine 2019 17:153

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  32. Content type: Research

    The high mortality of patients with non-small cell lung cancer (NSCLC) emphasizes the necessity of identifying a robust and reliable prognostic signature for NSCLC patients. This study aimed to identify and va...

    Authors: Shuguang Zuo, Min Wei, Hailin Zhang, Anxian Chen, Junhua Wu, Jiwu Wei and Jie Dong

    Citation: Journal of Translational Medicine 2019 17:152

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  33. Content type: Research

    Fulminant liver failure (FHF) is a serious clinical problem and liver transplantation is the major intervention. But the overall survival rate of FHF is low owing to the donated organ shortage. Apolipoprotein ...

    Authors: Ya-Chao Tao, Meng-Lan Wang, Dong-Bo Wu, Chen Luo, Hong Tang and En-Qiang Chen

    Citation: Journal of Translational Medicine 2019 17:151

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  34. Content type: Research

    Esophageal cancer (EC) is one of the deadliest cancers worldwide. The contemporary strong increase of the adenocarcinomas in Western countries and the high mortality rates require the intensification of prospe...

    Authors: Doris Klingelhöfer, Yun Zhu, Markus Braun, Dörthe Brüggmann, Norman Schöffel and David A. Groneberg

    Citation: Journal of Translational Medicine 2019 17:150

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  35. Content type: Research

    Aberrant metabolism is a hallmark of cancer cells. Recently, ATP citrate-lyase (ACLY) expression was demonstrated as an independent predictor of clinical outcome in solid tumors. However, no systematic study was ...

    Authors: Jinghan Wang, Wenle Ye, Xiao Yan, Qi Guo, Qiuling Ma, Fang Lin, Jiansong Huang and Jie Jin

    Citation: Journal of Translational Medicine 2019 17:149

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  36. Content type: Meeting report

    The great debate session at the 2018 Melanoma Bridge congress (November 29–December 1, Naples, Italy) featured counterpoint views from experts on three topical issues in melanoma. These were whether overall su...

    Authors: Paolo A. Ascierto, Paolo Bruzzi, Alexander Eggermont, Omid Hamid, Hussein A. Tawbi, Alexander van Akkooi, Alessandro Testori, Corrado Caracò, Igor Puzanov and Francesco Perrone

    Citation: Journal of Translational Medicine 2019 17:148

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  37. Content type: Research

    Interferon gamma (IFNγ) plays an important role in the development of chronic lung diseases via the production of inflammatory mediators, although the exact mechanism remains unclear. The present study aimed a...

    Authors: Yichun Zhu, Dongli Song, Yuanlin Song and Xiangdong Wang

    Citation: Journal of Translational Medicine 2019 17:147

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  38. Content type: Research

    The available prognostic scoring systems for severe acute pancreatitis (SAP) have limitations that restrict their clinical value. The aim of this study was to develop a simple model (score) that could rapidly ...

    Authors: Wandong Hong, Keith D. Lillemoe, Shuang Pan, Vincent Zimmer, Evangelos Kontopantelis, Simon Stock, Maddalena Zippi, Chao Wang and Mengtao Zhou

    Citation: Journal of Translational Medicine 2019 17:146

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  39. Content type: Research

    Nutrition of the newborn during the early postnatal period seems to be of capital importance and there is clinical evidence showing the protective effect of breastfeeding compared with formula feeding on child...

    Authors: Julio Alvarez-Pitti, Maria Amparo Ros-Forés, Ana Bayo-Pérez, Mariona Palou, Empar Lurbe, Andreu Palou and Catalina Picó

    Citation: Journal of Translational Medicine 2019 17:145

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  40. Content type: Research

    The role of γδ T cells, innate-like lymphocytes with unrestrained MHC, in various malignancies has recently been extensively studied. However, there is limited research regarding γδ T cells in ovarian cancer (...

    Authors: Xian Chen, Wenwen Shang, Rui Xu, Ming Wu, Xiaojie Zhang, Peijun Huang, Fang Wang and Shiyang Pan

    Citation: Journal of Translational Medicine 2019 17:144

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  41. Content type: Research

    The distant metastasis of cancer cells is a risk factor for tumor lethality and poor prognosis in non-small-cell lung carcinoma (NSCLC). Increased SOX9 expression has been associated with clinical stage and po...

    Authors: Jing-Qiang Huang, Fa-Kai Wei, Xiu-Li Xu, Shi-Xing Ye, Jun-Wei Song, Pei-Kun Ding, Jing Zhu, He-Feng Li, Xin-Ping Luo, Hui Gong, Li Su, Lin Yang and Li-Yun Gong

    Citation: Journal of Translational Medicine 2019 17:143

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  42. Content type: Review

    Mitochondria take part in a network of cellular processes that regulate cell homeostasis. Defects in mitochondrial function are key pathophysiological changes during acute kidney injury (AKI). Mesenchymal stem...

    Authors: Lingfei Zhao, Chenxia Hu, Ping Zhang, Hua Jiang and Jianghua Chen

    Citation: Journal of Translational Medicine 2019 17:142

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  43. Content type: Research

    Rupture of an intracranial aneurysm (IA) causes a systemic response that involves an immune/inflammatory reaction. Our previous study revealed a downregulation of genes related to T lymphocytes and an upregula...

    Authors: Michal Korostynski, Marcin Piechota, Rafal Morga, Dzesika Hoinkis, Slawomir Golda, Magdalena Zygmunt, Tomasz Dziedzic, Marek Moskala, Agnieszka Slowik and Joanna Pera

    Citation: Journal of Translational Medicine 2019 17:141

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  44. Content type: Research

    Serum GP73 is a useful biomarker in assessing hepatic fibrosis degree. The aim of this study was to evaluate the predictive value of serum GP73 level for posthepatectomy short-term outcomes in hepatocellular c...

    Authors: Meng-yun Ke, Xiao-ning Wu, Yao Zhang, Saisai Wang, Yi Lv and Jian Dong

    Citation: Journal of Translational Medicine 2019 17:140

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  45. Content type: Research

    Acute kidney injury (AKI) is a common complication of acute myocardial infarction (AMI), and is associated with adverse outcomes. The study aimed to identify a miRNA signature for the early diagnosis of post-A...

    Authors: Pei-Chun Fan, Chia-Chun Chen, Chen-Ching Peng, Chih-Hsiang Chang, Chia-Hung Yang, Chi Yang, Lichieh Julie Chu, Yung-Chang Chen, Chih-Wei Yang, Yu-Sun Chang and Pao-Hsien Chu

    Citation: Journal of Translational Medicine 2019 17:139

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  46. Content type: Research

    Genomic disorders present a wide spectrum of unrelated clinical entities that result from genomic rearrangements. Interstitial insertions requiring three points of breakage are rare genomic rearrangement event...

    Authors: Nuo Si, Xiaolu Meng, Zhen Zhao, Weibo Xia and Xue Zhang

    Citation: Journal of Translational Medicine 2019 17:138

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  47. Content type: Research

    Over the past few years, next-generation sequencing (NGS) has become reliable and cost-effective, and its use in clinical practice has become a reality. A relevant role for NGS is the prediction of response to...

    Authors: Edoardo Isnaldi, Anna Garuti, Gabriella Cirmena, Stefano Scabini, Edoardo Rimini, Lorenzo Ferrando, Michela Lia, Roberto Murialdo, Lucia Tixi, Enrico Carminati, Andrea Panaro, Maurizio Gallo, Federica Grillo, Luca Mastracci, Lazzaro Repetto, Roberto Fiocca…

    Citation: Journal of Translational Medicine 2019 17:137

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  48. Content type: Research

    Remote ischemic preconditioning (RIPC) is a phenomenon, whereby repeated, non-lethal episodes of ischemia to an organ or limb exert protection against ischemia–reperfusion (I/R) injury in distant organs. Despi...

    Authors: Lars Hummitzsch, Karina Zitta, Rouven Berndt, Yuk Lung Wong, Rene Rusch, Katharina Hess, Thilo Wedel, Matthias Gruenewald, Jochen Cremer, Markus Steinfath and Martin Albrecht

    Citation: Journal of Translational Medicine 2019 17:136

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  49. Content type: Research

    Low back pain has become a serious social and economic burden and the leading cause of disability worldwide. Among a variety of pathophysiological triggers, intervertebral disc (IVD) degeneration plays a prima...

    Authors: Xubin Qiu, Ming Zhuang, Ziwen Lu, Zhiwei Liu, Dong Cheng, Chenlei Zhu and Jinbo Liu

    Citation: Journal of Translational Medicine 2019 17:135

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Journal of Translational Medicine

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