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  1. Proprotein convertase subtilisin/kexin 9 (PCSK9) has been proposed as a novel target for coronary artery disease (CAD). Familial hypercholesterolemia (FH) is characterized by high prevalence of CAD and major c...

    Authors: Ye-Xuan Cao, Jing-Lu Jin, Di Sun, Hui-Hui Liu, Yuan-Lin Guo, Na-Qiong Wu, Rui-Xia Xu, Cheng-Gang Zhu, Qian Dong, Jing Sun and Jian-Jun Li

    Citation: Journal of Translational Medicine 2019 17:367

    Content type: Research

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  2. Myelodysplastic syndrome (MDS) can progress to acute myeloid leukemia (AML), and conventional chemotherapy (decitabine) does not effectively inhibit tumor cells. Enhancer of zeste homologue 2 (EZH2) and Heme o...

    Authors: Zhengchang He, Siyu Zhang, Dan Ma, Qin Fang, Liping Yang, Shaoxian Shen, Ying Chen, Lingli Ren and Jishi Wang

    Citation: Journal of Translational Medicine 2019 17:366

    Content type: Research

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  3. There continues to be a great need for better biomarkers and host-directed treatment targets for community-acquired pneumonia (CAP). Alterations in phospholipid metabolism may constitute a source of small mole...

    Authors: Haroon Arshad, Juan Carlos López Alfonso, Raimo Franke, Katina Michaelis, Leonardo Araujo, Aamna Habib, Yuliya Zboromyrska, Eva Lücke, Emilia Strungaru, Manas K. Akmatov, Haralampos Hatzikirou, Michael Meyer-Hermann, Astrid Petersmann, Matthias Nauck, Mark Brönstrup, Ursula Bilitewski…

    Citation: Journal of Translational Medicine 2019 17:365

    Content type: Research

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  4. A wide debate is ongoing regarding the role of cutaneous dysbiosis in the pathogenesis and evolution of difficult-to-treat chronic wounds. Nowadays, probiotic treatment considered as an useful tool to countera...

    Authors: Salvatore Venosi, Giancarlo Ceccarelli, Massimiliano de Angelis, Luca Laghi, Laura Bianchi, Ombretta Martinelli, Debora Maruca, Eugenio Nelson Cavallari, Fabrizia Toscanella, Paolo Vassalini, Vito Trinchieri, Alessandra Oliva and Gabriella d’Ettorre

    Citation: Journal of Translational Medicine 2019 17:364

    Content type: Research

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  5. Growing evidence has demonstrated immune reactivity as a confirmed important carcinogenesis and therapy efficacy for clear cell renal cell carcinoma (ccRCC). Aquaporin 9 (AQP9) is involved in many immune-relat...

    Authors: Wen-Hao Xu, Shen-Nan Shi, Yue Xu, Jun Wang, Hong-Kai Wang, Da-Long Cao, Guo-Hai Shi, Yuan-Yuan Qu, Hai-Liang Zhang and Ding-Wei Ye

    Citation: Journal of Translational Medicine 2019 17:363

    Content type: Research

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  6. Middle East Respiratory Syndrome Coronavirus (MERS-COV) is the main cause of lung and kidney infections in developing countries such as Saudi Arabia and South Korea. This infectious single-stranded, positive (...

    Authors: Muhammad Tahir ul Qamar, Saman Saleem, Usman Ali Ashfaq, Amna Bari, Farooq Anwar and Safar Alqahtani

    Citation: Journal of Translational Medicine 2019 17:362

    Content type: Research

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  7. Developmental processes in the placenta and the fetal brain are shaped by the similar biological signals. Evidence accumulates that adaptive responses of the placenta may influence central nervous system devel...

    Authors: Esmée M. Bijnens, Catherine Derom, Steven Weyers, Bram G. Janssen, Evert Thiery and Tim S. Nawrot

    Citation: Journal of Translational Medicine 2019 17:361

    Content type: Research

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  8. Acute kidney injury (AKI) has high morbidity and mortality in intensive care units (ICU). It can also lead to chronic kidney disease (CKD), more costs and longer hospital stay. Early identification of AKI is i...

    Authors: Qi Wang, Yi Tang, Jiaojiao Zhou and Wei Qin

    Citation: Journal of Translational Medicine 2019 17:359

    Content type: Research

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  9. Following publication of the original article [1], the authors reported errors in Figures 2, 3 and Figure 3 ‘continued’

    Authors: Longwen Xu, Zhiyuan Cheng, Chuanliang Cui, Xiaowen Wu, Huan Yu, Jun Guo and Yan Kong

    Citation: Journal of Translational Medicine 2019 17:358

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2019 17:245

  10. The 18-gene tumor inflammation signature (TIS) is a clinical research assay that enriches for clinical benefit to immune checkpoint blockade. We evaluated its ability to predict clinical benefit of immunothera...

    Authors: Diane Damotte, Sarah Warren, Jennifer Arrondeau, Pascaline Boudou-Rouquette, Audrey Mansuet-Lupo, Jérôme Biton, Hanane Ouakrim, Marco Alifano, Claire Gervais, Audrey Bellesoeur, Nora Kramkimel, Camille Tlemsani, Barbara Burroni, Angéline Duche, Franck Letourneur, Han Si…

    Citation: Journal of Translational Medicine 2019 17:357

    Content type: Research

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  11. The epidemic of obesity is growing steadily across the whole world. Obesity is not only a merely aesthetic disease but is the “mother” of most chronic diseases such as associated with a range of type 2 diabete...

    Authors: Giovanna Muscogiuri, Luigi Barrea, Daniela Laudisio, Gabriella Pugliese, Ciro Salzano, Silvia Savastano and Annamaria Colao

    Citation: Journal of Translational Medicine 2019 17:356

    Content type: Review

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  12. Exosomes are 50–150 nm endocytic vesicles secreted by almost all type of cells that carry bioactive molecules from host. These small vesicles are considered to be novel cross-talk circuits established by tumor...

    Authors: Chuling Li, Chuwei Li, Chunchun Zhi, Wenjun Liang, Xuan Wang, Xi Chen, Tangfeng Lv, Qin Shen, Yong Song, Dang Lin and Hongbing Liu

    Citation: Journal of Translational Medicine 2019 17:355

    Content type: Research

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  13. Pituitary adenoma and meningioma are the most common benign tumors in the central nervous system. Pituitary adenoma associated with meningioma (PAM) is a rare disease and the clinical features and mechanisms o...

    Authors: Haibo Zhu, Yazhou Miao, Yutao Shen, Jing Guo, Weiyan Xie, Sida Zhao, Wei Dong, Yazhuo Zhang and Chuzhong Li

    Citation: Journal of Translational Medicine 2019 17:354

    Content type: Research

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  14. The colorectum includes ascending colon, transverse colon, descending colon, sigmoid colon, and rectum. Different sites of colorectal cancer (CRC) are different in many aspects, including clinical symptoms, bi...

    Authors: Yang Xi, Pan Yuefen, Wu Wei, Qi Quan, Zhuang Jing, Xu Jiamin and Han Shuwen

    Citation: Journal of Translational Medicine 2019 17:353

    Content type: Research

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  15. Accumulating evidence indicates that CD36 initiates metastasis and correlates with an unfavorable prognosis in cancers. However, there are few reports regarding the roles of CD36 in initiation and metastasis o...

    Authors: Min Deng, Xiaodong Cai, Ling Long, Linying Xie, Hongmei Ma, Youjian Zhou, Shuguang Liu and Chao Zeng

    Citation: Journal of Translational Medicine 2019 17:352

    Content type: Research

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  16. Biallelic PTPRQ pathogenic variants have been previously reported as causative for autosomal recessive non-syndromic hearing loss. In 2018 the first heterozygous PTPRQ variant has been implicated in the developme...

    Authors: Dominika Oziębło, Anna Sarosiak, Marcin L. Leja, Birgit S. Budde, Grażyna Tacikowska, Nataliya Di Donato, Hanno J. Bolz, Peter Nürnberg, Henryk Skarżyński and Monika Ołdak

    Citation: Journal of Translational Medicine 2019 17:351

    Content type: Research

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  17. Magnetic resonance guided focused ultrasound was suggested for the induction of deep localized hyperthermia adjuvant to radiation- or chemotherapy. In this study we are aiming to validate an experimental model...

    Authors: Pauline C. Guillemin, Laura Gui, Orane Lorton, Thomas Zilli, Lindsey A. Crowe, Stéphane Desgranges, Xavier Montet, Sylvain Terraz, Raymond Miralbell, Rares Salomir and Sana Boudabbous

    Citation: Journal of Translational Medicine 2019 17:350

    Content type: Research

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  18. Subarachnoid hemorrhage (SAH) accounts for 4.4% of cerebral vascular disease, which is one of the leading causes of death in China. Rupture of intracranial aneurysms (IAs) is the most common cause of SAH. The ...

    Authors: Haixiao Liu, Wei Guo, Sishi Xiang, Peng Hu, Feifei Sun, Junmei Gao, Xiaoyang Zhang, Ping Wang, Wenting Jing, Lei Zhang, Xinjian Yang, Chuanzhi Duan, Min He, Hongqi Zhang and Yan Qu

    Citation: Journal of Translational Medicine 2019 17:349

    Content type: Protocol

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  19. Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated...

    Authors: Haya Al-Sulaiti, Ilhame Diboun, Maha V. Agha, Fatima F. S. Mohamed, Stephen Atkin, Alex S. Dömling, Mohamed A. Elrayess and Nayef A. Mazloum

    Citation: Journal of Translational Medicine 2019 17:348

    Content type: Research

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  20. Emerging evidence shows that microRNA-130 (miRNA-130) family may be useful as prognostic biomarkers in cancer. However, there is no confirmation in an independent validation study. The aim of this study was to...

    Authors: Zhen Peng, Fujiao Duan, Jingjing Yin, Yajing Feng, Zhongyu Yang and Jia Shang

    Citation: Journal of Translational Medicine 2019 17:347

    Content type: Research

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  21. Tibial fracture is associated with inflammatory reaction leading to severe pain syndrome. Bradykinin receptor activation is involved in inflammatory reactions, but has never been investigated in fracture pain.

    Authors: Vincent Minville, Lionel Mouledous, Acil Jaafar, Réjean Couture, Anne Brouchet, Bernard Frances, Ivan Tack and Jean-Pierre Girolami

    Citation: Journal of Translational Medicine 2019 17:346

    Content type: Research

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  22. Despite advances in clinical management, there are currently no novel therapeutic targets for acute respiratory distress syndrome (ARDS). DNA methylation, as a reversible process involved in the development an...

    Authors: Shi Zhang, Zongsheng Wu, Jianfeng Xie, Yi Yang, Lei Wang and Haibo Qiu

    Citation: Journal of Translational Medicine 2019 17:345

    Content type: Research

    Published on:

  23. Noninvasive prognostic biomarkers are needed for advanced non-small cell lung cancer (NSCLC) patients with different histological types to identify cases with poor survival. Here, we investigated the prognosti...

    Authors: Chao Liu, Wang Jing, Ning An, Aijie Li, Weiwei Yan, Hui Zhu and Jinming Yu

    Citation: Journal of Translational Medicine 2019 17:344

    Content type: Research

    Published on:

  24. Liver cancer is the second leading causes of cancer-related death globally. Pyrroline-5-carboxylate reductase 1 (PYCR1) plays a critical role in metabolic profiles of tumors. Therefore, it is necessary to expl...

    Authors: Juhua Zhuang, Yanan Song, Ying Ye, Saifei He, Xing Ma, Miao Zhang, Jing Ni, Jiening Wang and Wei Xia

    Citation: Journal of Translational Medicine 2019 17:343

    Content type: Research

    Published on:

  25. World Trade Center (WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. New York University (NYU) and Mount Sinai have recreated WTC exposure in rodents to observe the resulting ...

    Authors: Wil Lieberman-Cribbin, Stephanie Tuminello, Christina Gillezeau, Maaike van Gerwen, Rachel Brody, David J. Mulholland, Lori Horton, Maureen Sisco, Colette Prophete, Judith Zelikoff, Hyun-Wook Lee, Sung-Hyun Park, Lung-Chi Chen, Mitchell D. Cohen and Emanuela Taioli

    Citation: Journal of Translational Medicine 2019 17:342

    Content type: Research

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  26. The role of body fat distribution in uric acid metabolism is still ambiguity. We aimed to investigate the independent contribution of visceral adipose measured by visceral adiposity index and lipid accumulatio...

    Authors: Xiaolin Huang, Xiaohong Jiang, Long Wang, Lu Chen, Yang Wu, Pei Gao and Fei Hua

    Citation: Journal of Translational Medicine 2019 17:341

    Content type: Research

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  28. Pemetrexed combined with platinum complexes can be used as first-line treatment for advanced non-squamous non-small cell lung cancer (NSCLC), however, the efficacy and safety is varying from individuals. There...

    Authors: Xiaohong Han, Ying Han, Qiaoyun Tan, Yu Huang, Jianliang Yang, Sheng Yang, Xiaohui He, Shengyu Zhou, Yan Song, Jinping Pi, Lijie Zuo, Jiarui Yao, Di Wu, Zhishang Zhang and Yuankai Shi

    Citation: Journal of Translational Medicine 2019 17:339

    Content type: Research

    Published on:

  29. At present, immune checkpoint inhibitors, such as pembrolizumab, are widely used in the therapy of advanced non-resectable melanoma, as they induce more durable responses than other available treatments. Howev...

    Authors: Neta Tsur, Yuri Kogan, Evgenia Avizov-Khodak, Désirée Vaeth, Nils Vogler, Jochen Utikal, Michal Lotem and Zvia Agur

    Citation: Journal of Translational Medicine 2019 17:338

    Content type: Research

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  30. Genomic and radiomic data integration, namely radiogenomics, can provide meaningful knowledge in cancer diagnosis, prognosis and treatment. Despite several data structures based on multi-layer architecture pro...

    Authors: Mario Zanfardino, Monica Franzese, Katia Pane, Carlo Cavaliere, Serena Monti, Giuseppina Esposito, Marco Salvatore and Marco Aiello

    Citation: Journal of Translational Medicine 2019 17:337

    Content type: Review

    Published on:

  32. The P38 mitogen-activated protein kinase (MAPK) pathway plays an essential role in CVB3-induced diseases. We previously demonstrated microRNA-21 has potential inhibitory effect on the MAP2K3 which locates upst...

    Authors: Feng He, Zonghui Xiao, Hailan Yao, Sen Li, Miao Feng, Wei Wang, Zhewei Liu, Zhuo Liu and Jianxin Wu

    Citation: Journal of Translational Medicine 2019 17:335

    Content type: Research

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  33. MicroRNAs (miRNAs) are promising biomarkers due to their structural stability and distinct expression profile in various cancers. We wanted to explore the miRNA expression in benign breast tissue and breast ca...

    Authors: Line Moi, Tonje Braaten, Khalid Al-Shibli, Eiliv Lund and Lill-Tove Rasmussen Busund

    Citation: Journal of Translational Medicine 2019 17:334

    Content type: Research

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  34. In colorectal cancer surgery there is a delicate balance between complete removal of the tumor and sparing as much healthy tissue as possible. Especially in rectal cancer, intraoperative tissue recognition cou...

    Authors: E. J. M. Baltussen, S. G. Brouwer de Koning, J. Sanders, A. G. J. Aalbers, N. F. M. Kok, G. L. Beets, B. H. W. Hendriks, H. J. C. M. Sterenborg, K. F. D. Kuhlmann and T. J. M. Ruers

    Citation: Journal of Translational Medicine 2019 17:333

    Content type: Research

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  35. It has been established that children with Autism Spectrum Disorders (ASD) are affected by oxidative stress, the origin of which is still under investigation. In the present work, we evaluated inflammatory and...

    Authors: P. M. Abruzzo, A. Matté, A. Bolotta, E. Federti, A. Ghezzo, T. Guarnieri, M. Marini, A. Posar, A. Siciliano, L. De Franceschi and P. Visconti

    Citation: Journal of Translational Medicine 2019 17:332

    Content type: Research

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  36. Brain metastases (BM) are the most common intracranial tumors. 2–14% of BM patients present with unknown primary site despite intensive evaluations. This study aims to evaluate the performance of a 90-gene exp...

    Authors: Yulong Zheng, Yongfeng Ding, Qifeng Wang, Yifeng Sun, Xiaodong Teng, Qiqi Gao, Weixiang Zhong, Xiaofeng Lou, Cheng Xiao, Chengshu Chen, Qinghua Xu and Nong Xu

    Citation: Journal of Translational Medicine 2019 17:331

    Content type: Research

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  37. Best vitelliform macular dystrophy (BVMD) is an autosomal dominant macular degeneration. The typical central yellowish yolk-like lesion usually appears in childhood and gradually worsens. Most cases are caused...

    Authors: Vladimir Frecer, Giancarlo Iarossi, Anna Paola Salvetti, Paolo Enrico Maltese, Giulia Delledonne, Marta Oldani, Giovanni Staurenghi, Benedetto Falsini, Angelo Maria Minnella, Lucia Ziccardi, Adriano Magli, Leonardo Colombo, Fabiana D’Esposito, Jan Miertus, Francesco Viola, Marcella Attanasio…

    Citation: Journal of Translational Medicine 2019 17:330

    Content type: Research

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  38. Acute traumatic cervical spinal cord injury (SCI) is a leading cause of disability in adolescents and young adults worldwide. Evidence from previous studies suggests that circulating cell-free DNA is associate...

    Authors: Hung-Chen Wang, Yu-Tsai Lin, Shih-Yuan Hsu, Nai-Wen Tsai, Yun-Ru Lai, Ben Yu-Jih Su, Chia-Te Kung and Cheng-Hsien Lu

    Citation: Journal of Translational Medicine 2019 17:329

    Content type: Research

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  39. Liquid biopsy based on cell-free DNA circulating in plasma has shown solid results as a non-invasive biomarker. In the present study we evaluated the utility of circulating free DNA (cfDNA) and the sub-type tu...

    Authors: Marianna Alunni-Fabbroni, Kerstin Rönsch, Thomas Huber, Clemens C. Cyran, Max Seidensticker, Julia Mayerle, Maciej Pech, Bristi Basu, Chris Verslype, Julia Benckert, Peter Malfertheiner and Jens Ricke

    Citation: Journal of Translational Medicine 2019 17:328

    Content type: Research

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  40. Oxidative stress has a determinantal effect on human dental pulp stromal cells (hDPSCs), including affecting their longevity and functionality. Circular RNAs (circRNAs) play an essential role in stromal cell b...

    Authors: Jingying Zhang, Dan Li, Dan Wang, Kenny Man and Xuebin Yang

    Citation: Journal of Translational Medicine 2019 17:327

    Content type: Research

    Published on:

  41. To develop a machine learning model for predicting acute respiratory distress syndrome (ARDS) events through commonly available parameters, including baseline characteristics and clinical and laboratory parame...

    Authors: Xian-Fei Ding, Jin-Bo Li, Huo-Yan Liang, Zong-Yu Wang, Ting-Ting Jiao, Zhuang Liu, Liang Yi, Wei-Shuai Bian, Shu-Peng Wang, Xi Zhu and Tong-Wen Sun

    Citation: Journal of Translational Medicine 2019 17:326

    Content type: Research

    Published on:

  42. Breastfeeding is the ideal source of infant nutrition. Human milk consists not only of nutrients but also biologically active components. Among these latter compounds, exosomes contain proteins, lipids, mRNAs ...

    Authors: Shimon Reif, Yaffa Elbaum Shiff and Regina Golan-Gerstl

    Citation: Journal of Translational Medicine 2019 17:325

    Content type: Research

    Published on:

  43. DNA methylation can regulate the role of long noncoding RNAs (lncRNAs) in the development of lung adenocarcinoma (LUAD). The present study aimed to identify methylation-driven lncRNAs and mRNAs as biomarkers i...

    Authors: Rui Li, Yi-E Yang, Yun-Hong Yin, Meng-Yu Zhang, Hao Li and Yi-Qing Qu

    Citation: Journal of Translational Medicine 2019 17:324

    Content type: Research

    Published on:

  44. To investigate the association of serum levels of 25(OH)D and 1,25(OH)2D3 in healthy and non-healthy controls with Crohn’s disease (CD) and ulcerative colitis (UC).

    Authors: Xi-Xi Li, Yang Liu, Jie Luo, Zhen-Dong Huang, Chao Zhang and Yan Fu

    Citation: Journal of Translational Medicine 2019 17:323

    Content type: Research

    Published on:

  45. Recently, numerous biological experiments have indicated that microRNAs (miRNAs) play critical roles in exploring the pathogenesis of various human diseases. Since traditional experimental methods for miRNA-di...

    Authors: Guobo Xie, Zhiliang Fan, Yuping Sun, Cuiming Wu and Lei Ma

    Citation: Journal of Translational Medicine 2019 17:322

    Content type: Research

    Published on:

  46. Immunoglobulin A nephropathy (IgAN) is the leading cause of end-stage kidney disease. Previous mRNA microarray profiling studies of IgAN revealed inconsistent data. We sought to identify the aberrantly express...

    Authors: Youxia Liu, Xiangchun Liu, Junya Jia, Jie Zheng and Tiekun Yan

    Citation: Journal of Translational Medicine 2019 17:320

    Content type: Research

    Published on:

  47. Post-transcriptional modifications have been recently expanded with the addition of RNA editing, which is predominantly mediated by adenosine and cytidine deaminases acting on DNA and RNA. Here, we review the ...

    Authors: Theodoulakis Christofi and Apostolos Zaravinos

    Citation: Journal of Translational Medicine 2019 17:319

    Content type: Review

    Published on:

  48. Only few studies, with small patient cohorts, have evaluated the effect of radiotherapy (RT) for metaplastic breast cancer (MBC). Hence, it is important to investigate the role of RT in MBC survival using a la...

    Authors: Yongfeng Li, Meng Chen, Barbara Pardini, Mihnea P. Dragomir, Anthony Lucci and George A. Calin

    Citation: Journal of Translational Medicine 2019 17:318

    Content type: Research

    Published on:

  49. Infertility has become a global health issue with the number of couples seeking in vitro fertilization (IVF) worldwide continuing to rise. Some couples remain childless after several IVF cycles. Women undergoi...

    Authors: Jiahui Qiu, Pingping Li, Meng Dong, Xing Xin and Jichun Tan

    Citation: Journal of Translational Medicine 2019 17:317

    Content type: Research

    Published on:

  50. Advances in microRNAs (miRNAs) biomarkers have generated disease markers with potential clinical values. However, none of these published results have been applied in clinic until today. The main reason could ...

    Authors: Yanqin Niu, Sijian Xia, Mingyang Su, Quanjin Dang, Kang Kang, Li Li and Deming Gou

    Citation: Journal of Translational Medicine 2019 17:316

    Content type: Research

    Published on:

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