Articles

Three-dimensional nanostructured substrates enable dynamic detection of ALK-rearrangement in circulating tumor cells from treatment-naive patients with stage III/IV lung adenocarcinoma

Circulating tumor cells (CTC) shows great prospect to realize precision medicine in cancer patients.

Authors: Weiling He, Di Xu, Zhuo Wang, Hui Wu, Xianhong Xiang, Bing Tang, Wenting Jiang, Yongmei Cui, Han Wang, Neng Jiang, Yu Sun, Yangshan Chen, Shuhua Li, Minzhi Hou, Yang Zhang, Liantang Wang…

Systemic immune-inflammation index predicts prognosis of patients with advanced pancreatic cancer

Systemic inflammation and immune dysfunction have been proved to be associated with cancer progression and metastasis in various malignancies. The aim of this retrospective study was to evaluate the prognostic...

Authors: Ke Zhang, Yong-Qiang Hua, Dan Wang, Lian-Yu Chen, Cai-Jun Wu, Zhen Chen, Lu-Ming Liu and Hao Chen

Effectiveness of two different dose administration regimens of an IL-15 superagonist complex (ALT-803) in an orthotopic bladder cancer mouse model

We set out to determine if the administration of subcutaneous (SQ) ALT-803 was non-inferior to standard intravesical BCG treatment in a carcinogen induced mouse (C57BL/6J) bladder cancer model.

Authors: Hideki Furuya, Owen T. M. Chan, Ian Pagano, Chengjun Zhu, Nari Kim, Rafael Peres, Kanani Hokutan, Sarah Alter, Peter Rhode and Charles J. Rosser

The emerging role of WISP proteins in tumorigenesis and cancer therapy

Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression o...

Authors: Yi Liu, Yizuo Song, Miaomiao Ye, Xiaoli Hu, Z. Peter Wang and Xueqiong Zhu

Immunotherapy Bridge 2018 and Melanoma Bridge 2018: meeting abstracts

Authors:

Clinical and genetic risk factors for Fulvestrant treatment in post-menopause ER-positive advanced breast cancer patients

Among breast cancer (BC) patients, near 40% are post-menopause, and 70%–80% are hormone receptor (HR)-positive. About 30%–40% BC patients who are diagnosed as invasive carcinoma HR-positive BC would eventually...

Authors: Jingyu Liu, Jing Li, Hui Wang, Yikai Wang, Qiongzhi He, Xuefeng Xia, Zhe-Yu Hu and Quchang Ouyang

Hypercholesterolemia-induced increase in plasma oxidized LDL abrogated pro angiogenic response in kidney grafts

Renal transplantation is increasingly associated with the presence of comorbidity factors such as dyslipidemia which could influence the graft outcome. We hypothesized that hypercholesterolemia could affect va...

Authors: Thomas Kerforne, Frédéric Favreau, Tackwa Khalifeh, Souleymane Maiga, Geraldine Allain, Antoine Thierry, Manuel Dierick, Edouard Baulier, Clara Steichen and Thierry Hauet

Circulating miR-3659 may be a potential biomarker of dyslipidemia in patients with obesity

The present study attempted to identify potential key genes and miRNAs of dyslipidemia in obese, and to investigate the possible mechanisms associated with them.

Authors: Liu Miao, Rui-Xing Yin, Shang-Ling Pan, Shuo Yang, De-Zhai Yang and Wei-Xiong Lin

Regeneration of a neoartery through a completely autologous acellular conduit in a minipig model: a pilot study

Vascular grafts are widely used as a treatment in coronary artery bypass surgery, hemodialysis, peripheral arterial bypass and congenital heart disease. Various types of synthetic and natural materials were ex...

Authors: Tao Wang, Nianguo Dong, Huimin Yan, Sze Yue Wong, Wen Zhao, Kang Xu, Dong Wang, Song Li and Xuefeng Qiu

Single cell sequencing reveals gene expression signatures associated with bone marrow stromal cell subpopulations and time in culture

Bone marrow stromal cells (BMSCs) are a heterogeneous population that participates in wound healing, immune modulation and tissue regeneration. Next generation sequencing was used to analyze transcripts from s...

Authors: Shutong Liu, David F. Stroncek, Yingdong Zhao, Victoria Chen, Rongye Shi, Jinguo Chen, Jiaqiang Ren, Hui Liu, Hee Joon Bae, Steven L. Highfill and Ping Jin

MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo

Vascular shear stress promotes endothelial cell sprouting in vitro. The impact of hemodynamic forces on microRNA (miRNA) and gene expression within growing vascular networks in vivo, however, remain poorly inv...

Authors: Dominic Henn, Masood Abu-Halima, Dominik Wermke, Florian Falkner, Benjamin Thomas, Christoph Köpple, Nicole Ludwig, Matthias Schulte, Marc A. Brockmann, Yoo-Jin Kim, Justin M. Sacks, Ulrich Kneser, Andreas Keller, Eckart Meese and Volker J. Schmidt

Characteristics of T cell receptor repertoires of patients with acute myocardial infarction through high-throughput sequencing

T cells are key regulators of immunity and one of the cells recruited in atherosclerosis and participated in various stages of the development of atherosclerosis. Characterizing T-cell receptor (TCR) repertoir...

Authors: Zhixiong Zhong, Heming Wu, Qifeng Zhang, Wei Zhong and Pingsen Zhao

Translational control mechanisms in cutaneous malignant melanoma: the role of eIF2α

Melanoma cells develop adaptive responses in order to cope with particular conditions of tumor microenvironment, characterized by stress conditions and deregulated proliferation. Recently, the interplay betwee...

Authors: Immacolata Maida, Paola Zanna, Stefania Guida, Anna Ferretta, Tiziana Cocco, Luigi Leonardo Palese, Paola Londei, Dario Benelli, Amalia Azzariti, Stefania Tommasi, Michele Guida, Giovanni Pellacani and Gabriella Guida

Microbubble-mediated delivery of human adenoviruses does not elicit innate and adaptive immunity response in an immunocompetent mouse model of prostate cancer

Gene transfer to malignant sites using human adenoviruses (hAds) has been limited because of their immunogenic nature and host specificity. Murine cells often lack some of the receptors needed for hAds attachm...

Authors: Flavia De Carlo, Litty Thomas, Bell Brooke, Elliot T. Varney, Rounak Nande, Olivia Boskovic, Gailen D. Marshall, Pier Paolo Claudio and Candace M. Howard

Protein inhibitor of activated STAT3 reduces peripheral arthritis and gut inflammation and regulates the Th17/Treg cell imbalance via STAT3 signaling in a mouse model of spondyloarthritis

Spondyloarthritis (SpA) is chronic inflammatory arthritis, and interleukin (IL)-17 is crucial in SpA pathogenesis. Type 17 helper T (Th17) cells are one of major IL-17-secreting cells. Signal transducer and ac...

Authors: Hong-Ki Min, JeongWon Choi, Seon-Yeong Lee, Hyeon-Beom Seo, KyungAh Jung, Hyun Sik Na, Jun-Geol Ryu, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park

Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes

Early life is a period of drastic epigenetic remodeling in which the epigenome is especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide dynamics of the DNA methylation changes ...

Authors: Raúl F. Pérez, Pablo Santamarina, Juan Ramón Tejedor, Rocío G. Urdinguio, Julio Álvarez-Pitti, Pau Redon, Agustín F. Fernández, Mario F. Fraga and Empar Lurbe

A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers

Despite much progress in cancer research, its incidence and mortality continue to rise. A robust biomarker that would predict tumor behavior is highly desirable and could improve patient treatment and prognosis.

Authors: Wai Hoong Chang, Donall Forde and Alvina G. Lai

Clinical verification of the relationship between smoking and the immune microenvironment of breast cancer

The immune tumor microenvironment (iTME) is thought to affect the response to chemotherapy, and tumor-infiltrating lymphocytes (TILs) are often used as an indicator to evaluate the iTME. Smoking is involved in...

Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

In vitro effects of interleukin (IL)-1 beta inhibition on the epithelial-to-mesenchymal transition (EMT) of renal tubular and hepatic stellate cells

The epithelial to mesenchymal transition (EMT) is a multi-factorial biological mechanism involved in renal and hepatic fibrosis and the IL-1 beta has been assumed as a mediator of this process although data ar...

Authors: Valentina Masola, Amedeo Carraro, Simona Granata, Lorenzo Signorini, Gloria Bellin, Paola Violi, Antonio Lupo, Umberto Tedeschi, Maurizio Onisto, Giovanni Gambaro and Gianluigi Zaza

Establishment of clinical diagnosis model of Graves’ disease and Hashimoto’s thyroiditis

A clinical diagnosis model include thyroid functions, thyroid antibodies and radioactive iodine uptake (RAIU) of patients with hyperthyroidism were established and as new evaluation indicators for the differen...

Authors: Zhaohui Cui, Zhixiao Wang, Xiaoyun Liu, Yun Cai, Xinyu Xu and Tao Yang

Isolation of clinically relevant concentrations of bone marrow mesenchymal stem cells without centrifugation

This study examined the quality of bone marrow aspirates extracted using a novel, FDA cleared method to optimally target cells from the inner cortical iliac bone surface without the need for centrifugation. Th...

Authors: Michael Scarpone, Daniel Kuebler, Andrew Chambers, Carlo Maria De Filippo, Mariangela Amatuzio, Thomas E. Ichim, Amit N. Patel and Eugenio Caradonna

PRAME promotes epithelial-to-mesenchymal transition in triple negative breast cancer

The triple negative breast cancer (TNBC) paradox marks a major challenge in the treatment-decision making process. TNBC patients generally respond better to neoadjuvant chemotherapy compared to other breast ca...

Authors: Ghaneya Al-Khadairi, Adviti Naik, Remy Thomas, Boshra Al-Sulaiti, Shaheen Rizly and Julie Decock

Interferon-alpha 2 but not Interferon-gamma serum levels are associated with intramuscular fat in obese patients with nonalcoholic fatty liver disease

Intramuscular triglycerides (IMTGs) represent an important energy supply and a dynamic fat-storage depot that can expand during periods of elevated lipid availability and a fatty acid source. Ultrasonography (...

Authors: Giovanni Tarantino, Susan Costantini, Vincenzo Citro, Paolo Conforti, Francesca Capone, Angela Sorice and Domenico Capone

Identification of potential miRNA–mRNA regulatory network contributing to pathogenesis of HBV-related HCC

Hepatitis B virus (HBV) is one of the major risk factors of hepatocellular carcinoma (HCC). Increasing evidence indicates that microRNA (miRNA)–mRNA axis is involved in HCC. However, a comprehensive miRNA–mRNA...

Authors: Weiyang Lou, Jingxing Liu, Bisha Ding, Danni Chen, Liang Xu, Jun Ding, Donghai Jiang, Lin Zhou, Shusen Zheng and Weimin Fan

Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity

Hepatitis B virus (HBV) infections represent a global health problem and chronic hepatitis B (CHB) leads to liver cirrhosis and hepatocellular carcinoma. Thus, timely diagnosis of hepatitis B is crucial to ens...

Authors: Katharina Bröker, Robin Terzenbach, Frank Bentzien, Stefan Lüth and Werner Dammermann

Microbiome–metabolome reveals the contribution of gut–kidney axis on kidney disease

Dysbiosis represents changes in composition and structure of the gut microbiome community (microbiome), which may dictate the physiological phenotype (health or disease). Recent technological advances and effo...

Authors: Yuan-Yuan Chen, Dan-Qian Chen, Lin Chen, Jing-Ru Liu, Nosratola D. Vaziri, Yan Guo and Ying-Yong Zhao

An innovative total temporomandibular joint prosthesis with customized design and 3D printing additive fabrication: a prospective clinical study

Total temporomandibular joint (TMJ) prosthesis is an effective and reliable method of joint reconstruction. However, there is still an urgent need to design a new TMJ prosthesis because of no commercially avai...

Authors: JiSi Zheng, XuZhuo Chen, WenBo Jiang, ShanYong Zhang, MinJie Chen and Chi Yang

Exosomes of pasteurized milk: potential pathogens of Western diseases

Milk consumption is a hallmark of western diet. According to common believes, milk consumption has beneficial effects for human health. Pasteurization of cow’s milk protects thermolabile vitamins and other org...

Authors: Bodo C. Melnik and Gerd Schmitz

Prediction of postoperative complications of pediatric cataract patients using data mining

The common treatment for pediatric cataracts is to replace the cloudy lens with an artificial one. However, patients may suffer complications (severe lens proliferation into the visual axis and abnormal high i...

Authors: Kai Zhang, Xiyang Liu, Jiewei Jiang, Wangting Li, Shuai Wang, Lin Liu, Xiaojing Zhou and Liming Wang

Identification of a serum-based miRNA signature for response of esophageal squamous cell carcinoma to neoadjuvant chemotherapy

Neoadjuvant chemotherapy (NAC) has become the standard of care for resectable esophageal squamous cell carcinoma (ESCC) which is one of the most lethal cancers, to improve resectability and prognosis. On this ...

Authors: Yukiko Niwa, Suguru Yamada, Fuminori Sonohara, Keisuke Kurimoto, Masamichi Hayashi, Mitsuru Tashiro, Naoki Iwata, Mitsuro Kanda, Chie Tanaka, Daisuke Kobayashi, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara and Yasuhiro Kodera

FGFR1 expression defines clinically distinct subtypes in pancreatic cancer

The clinical significance of fibroblast growth factor receptor 1 (FGFR1) protein expression in pancreatic cancer is largely unknown. In this study, we aimed investigate the clinical significance of FGFR1 expre...

Authors: Farhan Haq, You-Na Sung, Inkeun Park, Mahmood Akhtar Kayani, Faizah Yousuf, Seung-Mo Hong and Sung-Min Ahn

Biomarkers from circulating neutrophil transcriptomes have potential to detect unruptured intracranial aneurysms

Intracranial aneurysms (IAs) are dangerous because of their potential to rupture and cause deadly subarachnoid hemorrhages. Previously, we found significant RNA expression differences in circulating neutrophil...

Authors: Vincent M. Tutino, Kerry E. Poppenberg, Lu Li, Hussain Shallwani, Kaiyu Jiang, James N. Jarvis, Yijun Sun, Kenneth V. Snyder, Elad I. Levy, Adnan H. Siddiqui, John Kolega and Hui Meng

Integrated analysis of dysregulated long non-coding RNAs/microRNAs/mRNAs in metastasis of lung adenocarcinoma

Lung adenocarcinoma (LUAD), largely remains a primary cause of cancer-related death worldwide. The molecular mechanisms in LUAD metastasis have not been completely uncovered.

Authors: Lifeng Li, Mengle Peng, Wenhua Xue, Zhirui Fan, Tian Wang, Jingyao Lian, Yunkai Zhai, Wenping Lian, Dongchun Qin and Jie Zhao

Intermittent versus continuous energy restriction on weight loss and cardiometabolic outcomes: a systematic review and meta-analysis of randomized controlled trials

This systematic review and meta-analysis summarized the most recent evidence on the efficacy of intermittent energy restriction (IER) versus continuous energy restriction on weight-loss, body composition, bloo...

Authors: Iolanda Cioffi, Andrea Evangelista, Valentina Ponzo, Giovannino Ciccone, Laura Soldati, Lidia Santarpia, Franco Contaldo, Fabrizio Pasanisi, Ezio Ghigo and Simona Bo

NovelmiRNA-25 inhibits AMPD2 in peripheral blood mononuclear cells of patients with systemic lupus erythematosus and represents a promising novel biomarker

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with various clinical manifestations. MicroRNAs (miRNAs) and immunometabolism are recognized as key elements in SLE pathogenesis; howeve...

Authors: Gangqiang Guo, Huijing Wang, Xinyu Shi, Lele Ye, Kai Wu, Kangmin Lin, Sisi Ye, Baoqing Li, Huidi Zhang, Qiaoai Lin, Shuang Ye, Xiangyang Xue and Chaosheng Chen

Identification of a novel role of IL-13Rα2 in human Glioblastoma multiforme: interleukin-13 mediates signal transduction through AP-1 pathway

Previously, we have demonstrated that Interleukin 13 receptor alpha 2 (IL-13Rα2) is overexpressed in approximate 78% Glioblastoma multiforme (GBM) samples. We have also demonstrated that IL-13Rα2 can serve as ...

Authors: Rukmini Bhardwaj, Akiko Suzuki, Pamela Leland, Bharat H. Joshi and Raj K. Puri

Identification of a multidimensional transcriptome signature for survival prediction of postoperative glioblastoma multiforme patients

Glioblastoma multiform (GBM) is a devastating brain tumor with maximum surgical resection, radiotherapy plus concomitant and adjuvant temozolomide (TMZ) as the standard treatment. Diverse clinicopathological a...

Authors: Wei-Zhen Gao, Lie-Mei Guo, Tian-Qi Xu, Yu-Hua Yin and Feng Jia

Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery

Breast cancer surgeons struggle with differentiating healthy tissue from cancer at the resection margin during surgery. We report on the feasibility of using diffuse reflectance spectroscopy (DRS) for real-tim...

Authors: Lisanne L. de Boer, Torre M. Bydlon, Frederieke van Duijnhoven, Marie-Jeanne T. F. D. Vranken Peeters, Claudette E. Loo, Gonneke A. O. Winter-Warnars, Joyce Sanders, Henricus J. C. M. Sterenborg, Benno H. W. Hendriks and Theo J. M. Ruers

Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer

Adenosine-to-inosine (A-to-I) RNA editing is catalyzed by adenosine deaminases acting on RNA (ADAR) enzymes. Recent evidence suggests that RNA editing of antizyme inhibitor 1 (AZIN1) RNA is emerging as a key epig...

Authors: Yoshinaga Okugawa, Yuji Toiyama, Kunitoshi Shigeyasu, Akira Yamamoto, Tsunehiko Shigemori, Chengzeng Yin, Takashi Ichikawa, Hiromi Yasuda, Hiroyuki Fujikawa, Shigeyuki Yoshiyama, Junichiro Hiro, Masaki Ohi, Toshimitsu Araki, Masato Kusunoki and Ajay Goel

Preoperative systemic immune-inflammation index predicts prognosis of patients with oral squamous cell carcinoma after curative resection

Deregulated inflammation and immune deficit both intricately associate with cancer initiation and progression, which have been increasingly exploited as prognostic biomarkers and therapeutic targets. Recently,...

Authors: Pengfei Diao, Yaping Wu, Jin Li, Wei Zhang, Rong Huang, Chen Zhou, Yanling Wang and Jie Cheng

Pro-atherosclerotic disturbed flow disrupts caveolin-1 expression, localization, and function via glycocalyx degradation

Endothelial-dependent atherosclerosis develops in a non-random pattern in regions of vessel bending and bifurcations, where blood flow exhibits disturbed flow (DF) patterns. In contrast, uniform flow (UF), nor...

Authors: Ian C. Harding, Ronodeep Mitra, Solomon A. Mensah, Ira M. Herman and Eno E. Ebong

Prediction and prognostic significance of BCAR3 expression in patients with multiple myeloma

Multiple myeloma (MM) is the plasma cell tumor, which is characterized by clonal proliferation of tumor cells, with high risk of progression to renal impairment, bone damage and amyloidosis. Although the survi...

Authors: Weilong Zhang, Yuansheng Lin, Xiaoni Liu, Xue He, Ye Zhang, Wei Fu, Zuozhen Yang, Ping Yang, Jing Wang, Kai Hu, Xiuru Zhang, Weiyou Liu, Xiaoliang Yuan and Hongmei Jing

The roles of HLA-DQB1 gene polymorphisms in hepatitis B virus infection

Infection with the hepatitis B virus (HBV) is an independent risk factor for liver cirrhosis and hepatocellular carcinoma, polymorphisms in HLA-DQB1 play an important role in HBV infections.

Authors: Guojin Ou, Haixia Xu, Hao Yu, Xiao Liu, Liu Yang, Xin Ji, Jue Wang and Zhong Liu

Circular RNA regulatory network reveals cell–cell crosstalk in acute myeloid leukemia extramedullary infiltration

Acute myeloid leukemia can develop as myoblasts infiltrate into organs and tissues anywhere other than the bone marrow, which called extramedullary infiltration (EMI), indicating a poor prognosis. Circular RNA...

Authors: Chengfang Lv, Lili Sun, Zhibo Guo, Huibo Li, Desheng Kong, Bingqi Xu, Leilei Lin, Tianjiao Liu, Dan Guo, Jin Zhou and Yinghua Li

The ruxolitinib effect: understanding how molecular pathogenesis and epigenetic dysregulation impact therapeutic efficacy in myeloproliferative neoplasms

The myeloproliferative neoplasms (MPN), polycythaemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) are linked by a propensity to thrombosis formation and a risk of leukaemic transf...

Authors: Graeme Greenfield, Suzanne McPherson, Ken Mills and Mary Frances McMullin

Clinical significance of soluble immunoglobulins A and G and their coated bacteria in feces of patients with inflammatory bowel disease

Immunoglobulin A (IgA) and IgG are major components in human intestinal mucosal surface and sera, and IgA- or IgG-coated bacteria play a vital role in the intestinal homeostasis. However, the correlation of Ig...

Authors: Ritian Lin, Hongwei Chen, Weigang Shu, Mingming Sun, Leilei Fang, Yanhong Shi, Zhi Pang, Wei Wu and Zhanju Liu

Implementing a comprehensive translational oncology platform: from molecular testing to actionability

In order to establish the workflows required to implement a real-time process involving multi-omic analysis of patient samples to support precision-guided therapeutic intervention, a tissue acquisition and ana...

Authors: Zahi I. Mitri, Swapnil Parmar, Brett Johnson, Annette Kolodzie, Jamie M. Keck, Max Morris, Alexander R. Guimaraes, Brooke R. Beckett, Uma Borate, Charles D. Lopez, Kathleen A. Kemmer, Joshi J. Alumkal, Tomasz M. Beer, Christopher L. Corless, Gordon B. Mills, Joe W. Gray…

A novel semi-supervised model for miRNA-disease association prediction based on \(\ell_{1}\)-norm graph

Identification of miRNA-disease associations has attracted much attention recently due to the functional roles of miRNAs implicated in various biological and pathological processes. Great efforts have been mad...

Authors: Cheng Liang, Shengpeng Yu, Ka-Chun Wong and Jiawei Luo

Influence of endocrine therapy on the ratio of androgen receptor (AR) to estrogen receptor (ER) positive circulating epithelial tumor cells (CETCs) in breast cancer

The androgen receptor (AR) is expressed in the majority of breast cancers and across the main breast cancer subtypes. Despite the high frequency of AR expression in breast cancer its appraisal remains controve...

Authors: Monika Pizon, Daniel Lux, Ulrich Pachmann, Katharina Pachmann and Dorothea Schott

Diverse roles of macrophage polarization in aortic aneurysm: destruction and repair

Aortic aneurysm (AA) is defined as an enlargement of the aorta greater than 1.5 times its normal size. Early diagnosis of AA is challenging and mortality of AA is high. Curative pharmacological treatments for ...

Authors: Zhao Cheng, Yang-zhao Zhou, Yin Wu, Qi-ying Wu, Xiao-bo Liao, Xian-ming Fu and Xin-min Zhou