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  1. The tumor immune microenvironment is a heterogeneous entity. Gene expression analysis allows us to perform comprehensive immunoprofiling and may assist in dissecting the different components of the immune infi...

    Authors: W. S. M. E. Theelen, O. Krijgsman, K. Monkhorst, T. Kuilman, D. D. G. C. Peters, S. Cornelissen, M. A. Ligtenberg, S. M. Willems, J. L. G. Blaauwgeers, C. J. M. van Noesel, D. S. Peeper, M. M. van den Heuvel and K. Schulze

    Citation: Journal of Translational Medicine 2020 18:271

    Content type: Research

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  2. Previous research has focused on intensive care unit (ICU)-acquired hypernatremia; however, ICU-acquired hyponatremia has frequently been overlooked and has rarely been studied in surgical or mixed ICUs. The a...

    Authors: Jae Kyeom Sim, Ryoung-Eun Ko, Soo Jin Na, Gee Young Suh and Kyeongman Jeon

    Citation: Journal of Translational Medicine 2020 18:268

    Content type: Research

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  3. High burden of chronic cardio-metabolic disorders including type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD), and cardiovascular disease (CVD) have been reported in the Middle East and North Afric...

    Authors: Samaneh Asgari, Fatemeh Moosaie, Davood Khalili, Fereidoun Azizi and Farzad Hadaegh

    Citation: Journal of Translational Medicine 2020 18:267

    Content type: Research

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  4. Few studies have delved into the prevalence of distant metastasis (DM +) and survival for patients with lymph node metastases (LN +) by primary site. We aimed to detect differences in distant metastasis and pr...

    Authors: Xin Lou, Jun Li, Ya-Qing Wei, Zhi-Jia Jiang, Ming Chen and Jin-Jin Sun

    Citation: Journal of Translational Medicine 2020 18:266

    Content type: Research

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  5. NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity that results in therapeutic failure in pediatric acute lymphoblastic leukemia (ALL). However, many patients wi...

    Authors: Yoomi Park, Hyery Kim, Heewon Seo, Jung Yoon Choi, Youngeun Ma, Sunmin Yun, Byung-Joo Min, Myung-Eui Seo, Keon Hee Yoo, Hyoung Jin Kang, Ho Joon Im and Ju Han Kim

    Citation: Journal of Translational Medicine 2020 18:265

    Content type: Research

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  6. Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their cl...

    Authors: Hyun Sik Na, Seon-yeong Lee, Hong Ki Min, Wan-je Park, Jung-hwan Lee, Ka-hee Cho, Shin-hee Hong, Dae-hoon Kim, Jooyeon Jhun, Jeong-Won Choi, Sung-Min Kim, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park

    Citation: Journal of Translational Medicine 2020 18:264

    Content type: Research

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  7. Aim of this study was to assess changes in cardiac morphometric parameters at different stages of pulmonary arterial hypertension (PAH) using a monocrotaline-induced rat model.

    Authors: Mateusz K. Hołda, Elżbieta Szczepanek, Joanna Bielawska, Natalia Palka, Dorota Wojtysiak, Paulina Frączek, Michał Nowakowski, Natalia Sowińska, Zbigniew Arent, Piotr Podolec and Grzegorz Kopeć

    Citation: Journal of Translational Medicine 2020 18:262

    Content type: Research

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  8. Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansio...

    Authors: Adam Brufsky, Juan Luis Gomez Marti, Azadeh Nasrazadani and Michael T. Lotze

    Citation: Journal of Translational Medicine 2020 18:261

    Content type: Review

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  9. Worldwide, 70% of the adult population has limited expression of lactase enzyme with a wide variation among different regions and countries. Lactase deficiency may lead to lactose intolerance (LI). Depending b...

    Authors: Maria Sole Facioni, Benedetta Raspini, Francesca Pivari, Elena Dogliotti and Hellas Cena

    Citation: Journal of Translational Medicine 2020 18:260

    Content type: Review

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  10. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Karolina Okła, Alicja Rajtak, Arkadiusz Czerwonka, Marcin Bobiński, Anna Wawruszak, Rafał Tarkowski, Wiesława Bednarek, Justyna Szumiło and Jan Kotarski

    Citation: Journal of Translational Medicine 2020 18:258

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2020 18:220

  11. The recent global pandemic has placed a high priority on identifying drugs to prevent or lessen clinical infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused by Coronavirus disease...

    Authors: Jason Kim, Jenny Zhang, Yoonjeong Cha, Sarah Kolitz, Jason Funt, Renan Escalante Chong, Scott Barrett, Rebecca Kusko, Ben Zeskind and Howard Kaufman

    Citation: Journal of Translational Medicine 2020 18:257

    Content type: Research

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  12. This is an exploratory study using a novel imaging modality, quantitative ultrashort time-to-echo, contrast enhanced (QUTE-CE) magnetic resonance imaging to evaluate the permeability of the blood–brain barrier...

    Authors: Ju Qiao, Christopher M. Lawson, Kilian F. G. Rentrup, Praveen Kulkarni and Craig F. Ferris

    Citation: Journal of Translational Medicine 2020 18:256

    Content type: Methodology

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  13. Patient-derived xenograft (PDX) mouse models of cancer have been recognized as better mouse models that recapitulate the characteristics of original malignancies including preserved tumor heterogeneity, lineag...

    Authors: Zhenyang Liu, Michael Ho-Young Ahn, Tomohiro Kurokawa, Amy Ly, Gong Zhang, Fuyou Wang, Teppei Yamada, Ananthan Sadagopan, Jane Cheng, Cristina R. Ferrone, Andrew S. Liss, Kim C. Honselmann, Gregory R. Wojtkiewicz, Soldano Ferrone and Xinhui Wang

    Citation: Journal of Translational Medicine 2020 18:255

    Content type: Research

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  14. Overexpression of Wilms’ tumor-1 (WT1) transcription factor facilitates proliferation in acute myeloid leukemia (AML). However, whether WT1 is enriched in the leukemia-initiating cells (LICs) and leukemia stem ce...

    Authors: Bin Zhou, Xianghong Jin, Weiwei Jin, Xingzhou Huang, Yanfei Wu, Haiying Li, Weijian Zhu, Xiaoyi Qin, Haige Ye and Shenmeng Gao

    Citation: Journal of Translational Medicine 2020 18:254

    Content type: Research

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  15. The “Right-to-Try” experimental drugs act passed by Donald Trump in 2018 provides an opportunity of early access to experimental drugs for the treatment of life-threatening diseases and a potential boon to man...

    Authors: Vijay Mahant

    Citation: Journal of Translational Medicine 2020 18:253

    Content type: Review

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  16. Immunotherapy with checkpoint inhibitors (CI) represents an important novel development in cancer treatment. Metastatic triple-negative breast cancer (mTNBC) is incurable, with a median survival of only ~ 13 m...

    Authors: J. A. Kyte, A. Røssevold, R. S. Falk and B. Naume

    Citation: Journal of Translational Medicine 2020 18:252

    Content type: Protocol

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  17. With the aim of providing a dynamic evaluation of the effects of basic environmental parameters on COVID-19-related death rate, we assessed the correlation between average monthly high temperatures and populat...

    Authors: Francesca Benedetti, Maria Pachetti, Bruna Marini, Rudy Ippodrino, Robert C. Gallo, Massimo Ciccozzi and Davide Zella

    Citation: Journal of Translational Medicine 2020 18:251

    Content type: Research

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  18. Refractory central nervous system (CNS) involvement is among the major causes of therapy failure in childhood acute leukemia. Applying contemporary diagnostic methods, CNS disease is often underdiagnosed. To e...

    Authors: Bálint Egyed, Nóra Kutszegi, Judit C. Sági, András Gézsi, Andrea Rzepiel, Tamás Visnovitz, Péter Lőrincz, Judit Müller, Marianna Zombori, Csaba Szalai, Dániel J. Erdélyi, Gábor T. Kovács and Ágnes F. Semsei

    Citation: Journal of Translational Medicine 2020 18:250

    Content type: Research

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  19. The attraction and influx of monocytes into the retina has been considered a critical step in the development of diabetic retinopathy (DR). However, large population studies about the association between perip...

    Authors: Heng Wan, Yan Cai, Yuying Wang, Sijie Fang, Chi Chen, Yi Chen, Fangzhen Xia, Ningjian Wang, Minghao Guo and Yingli Lu

    Citation: Journal of Translational Medicine 2020 18:248

    Content type: Research

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  20. Glutathione peroxidases (GPxs) belong to a family of enzymes that is important in organisms; these enzymes promote hydrogen peroxide metabolism and protect cell membrane structure and function from oxidative d...

    Authors: Man-Li Zhang, Hua-Tao Wu, Wen-Jia Chen, Ya Xu, Qian-Qian Ye, Jia-Xin Shen and Jing Liu

    Citation: Journal of Translational Medicine 2020 18:247

    Content type: Review

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  21. Post-exertional malaise (PEM), the cardinal feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), occurs generally after exposure to a stressor. It is characterized by the worsening of ME/CFS...

    Authors: Alaa Ghali, Paul Richa, Carole Lacout, Aline Gury, Anne-Berengere Beucher, Chadi Homedan, Christian Lavigne and Geoffrey Urbanski

    Citation: Journal of Translational Medicine 2020 18:246

    Content type: Research

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  22. Post-transcriptional methylation modifications, including 5-methylcytosine (m5C) modification, are closely related to the tumorigenesis of cancers. However, the mRNA profile of m5C modification in hepatocellul...

    Authors: Qiyao Zhang, Qingyuan Zheng, Xiao Yu, Yuting He and Wenzhi Guo

    Citation: Journal of Translational Medicine 2020 18:245

    Content type: Research

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  23. Microtia is a congenital anomaly of ear that ranges in severity from mild structural abnormalities to complete absence of the outer ears. Concha-type microtia is considered to be a mild form. The H6 family hom...

    Authors: Nuo Si, Xiaolu Meng, Xiaosheng Lu, Zhe Liu, Zhan Qi, Lianqing Wang, Chuan Li, Meirong Yang, Ye Zhang, Changchen Wang, Peipei Guo, Lingdong Zhu, Lei Liu, Zhengyong Li, Zhenyu Zhang, Zhen Cai…

    Citation: Journal of Translational Medicine 2020 18:244

    Content type: Research

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  24. Lung cancer (LC) remains the deadliest form of cancer globally. While surgery remains the optimal treatment strategy for individuals with early-stage LC, what the metabolic consequences are of such surgical in...

    Authors: Dawei Yang, Xiaofang Yang, Yang Li, Peige Zhao, Rao Fu, Tianying Ren, Ping Hu, Yaping Wu, Hongjun Yang and Na Guo

    Citation: Journal of Translational Medicine 2020 18:243

    Content type: Research

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  25. Pools of overlapping synthetic peptides are routinely used for ex vivo monitoring of antigen-specific T-cell responses. However, it is rather unlikely that these peptides match those resulting from naturally p...

    Authors: Nina Körber, Uta Behrends, Ulrike Protzer and Tanja Bauer

    Citation: Journal of Translational Medicine 2020 18:242

    Content type: Methodology

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  26. Mesenchymal stem cells (MSCs) have been shown to alleviate acute lung injury (ALI) and induce the production of regulatory dendritic cells (DCregs), but the potential link between these two cell types remains ...

    Authors: Zhonghua Lu, Shanshan Meng, Wei Chang, Shanwen Fan, Jianfeng Xie, Fengmei Guo, Yi Yang, Haibo Qiu and Ling Liu

    Citation: Journal of Translational Medicine 2020 18:241

    Content type: Research

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  27. Although oropharyngeal squamous cell carcinoma (OPSCC) with human papillomavirus (HPV) infection has a good prognosis, the accurate prediction of survival and risk of treatment failure is essential to design d...

    Authors: Soohyeon Kwon, Soon-Hyun Ahn, Woo-Jin Jeong, Young Ho Jung, Yun Jung Bae, Jin Ho Paik, Jin-Haeng Chung and Hyojin Kim

    Citation: Journal of Translational Medicine 2020 18:240

    Content type: Research

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  28. Variable resistance has been shown to induce greater total work and muscle activation when compared to constant resistance. However, little is known regarding the effects of chronic exposure to variable resist...

    Authors: Hamid Arazi, Lida Salek, Elham Nikfal, Mani Izadi, James J. Tufano, Bradley T. Elliott and Matt Brughelli

    Citation: Journal of Translational Medicine 2020 18:239

    Content type: Research

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  29. Controversy remains whether white coat hypertension (WCH) is associated with renal prognosis in patients with chronic kidney disease (CKD).

    Authors: Qin Wang, Yu Wang, Jinwei Wang, Luxia Zhang and Ming-hui Zhao

    Citation: Journal of Translational Medicine 2020 18:238

    Content type: Research

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    The Correction to this article has been published in Journal of Translational Medicine 2020 18:282

  30. Survival outcomes of patients with resected SCLC differ widely. The aim of our study was to build a model for individualized risk assessment and accurate prediction of overall survival (OS) in resectable SCLC ...

    Authors: Yu Wang, Zhaofei Pang, Xiaowei Chen, Tao Yan, Jichang Liu and Jiajun Du

    Citation: Journal of Translational Medicine 2020 18:237

    Content type: Research

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  31. The in vitro production of mature human red blood cells (RBCs) from induced pluripotent stem cells (iPSCs) has been the focus of research to meet the high demand for blood transfusions. However, limitations li...

    Authors: Yu Jin Park, Su-Hee Jeon, Hyun-Kyung Kim, Eun Jung Suh, Seung Jun Choi, Sinyoung Kim and Hyun Ok Kim

    Citation: Journal of Translational Medicine 2020 18:236

    Content type: Research

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  32. Immune checkpoint inhibitors (ICIs) have been increasingly applied in the treatment of several kinds of malignancies. Some clinical demographic characteristics were reported to be associated with the ICIs effi...

    Authors: Yue An, Zhonghua Wu, Ningning Wang, Zhidong Yang, Yue Li, Boyang Xu and Mingjun Sun

    Citation: Journal of Translational Medicine 2020 18:235

    Content type: Research

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  33. Cancer-related mortality in patients with colorectal cancer (CRC) is predominantly caused by development of colorectal liver metastases (CLMs). How to screen the sensitive chemotherapy and targeted therapy is ...

    Authors: Mi Jian, Li Ren, Guodong He, Qi Lin, Wentao Tang, Yijiao Chen, Jingwen Chen, Tianyu Liu, Meiling Ji, Ye Wei, Wenju Chang and Jianmin Xu

    Citation: Journal of Translational Medicine 2020 18:234

    Content type: Research

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  34. Epidemiological, virological and pathogenetic characteristics of SARS-CoV-2 infection are under evaluation. A better understanding of the pathophysiology associated with COVID-19 is crucial to improve treatmen...

    Authors: Francesco Messina, Emanuela Giombini, Chiara Agrati, Francesco Vairo, Tommaso Ascoli Bartoli, Samir Al Moghazi, Mauro Piacentini, Franco Locatelli, Gary Kobinger, Markus Maeurer, Alimuddin Zumla, Maria R. Capobianchi, Francesco Nicola Lauria and Giuseppe Ippolito

    Citation: Journal of Translational Medicine 2020 18:233

    Content type: Research

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  35. In the context of our Regional Program of Hereditary Cancer, individuals fulfilling the criteria are tested for germline mutations to subsequently establish the clinical management. Our standard diagnostic app...

    Authors: Carolina Velázquez, Enrique Lastra, Francisco Avila Cobos, Luis Abella, Virginia de la Cruz, Blanca Ascensión Hernando, Lara Hernández, Noemí Martínez, Mar Infante and Mercedes Durán

    Citation: Journal of Translational Medicine 2020 18:232

    Content type: Research

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  36. Myocardial infarction (MI) is one of the most severe manifestations of coronary artery disease (CAD) and the leading cause of death from non-infectious diseases worldwide. It is known that the central componen...

    Authors: German Osmak, Natalia Baulina, Philipp Koshkin and Olga Favorova

    Citation: Journal of Translational Medicine 2020 18:231

    Content type: Research

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  37. Inflammation-related atherosclerotic peripheral vascular disease is a major end organ complication of diabetes mellitus that results in devastating morbidity and mortality. Extracellular vesicles (EVs) are nan...

    Authors: Sharon F. Wu, Nicole Noren Hooten, David W. Freeman, Nicolle A. Mode, Alan B. Zonderman and Michele K. Evans

    Citation: Journal of Translational Medicine 2020 18:230

    Content type: Research

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  38. On December 12th 2019, a new coronavirus (SARS-Cov2) emerged in Wuhan, China, sparking a pandemic of acute respiratory syndrome in humans (COVID-19). On the 24th of April 2020, the number of COVID-19 deaths in...

    Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Giulia Cinelli, Claudia Leggeri, Giovanna Caparello, Luigi Barrea, Francesco Scerbo, Ernesto Esposito and Antonino De Lorenzo

    Citation: Journal of Translational Medicine 2020 18:229

    Content type: Research

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  39. Most studies to assess effort intolerance in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have used questionnaires. Few studies have compared questionnaires with objective measures...

    Authors: C. M. C. van Campen, Peter C. Rowe, Freek W. A. Verheugt and Frans C. Visser

    Citation: Journal of Translational Medicine 2020 18:228

    Content type: Research

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  40. Electrical impedance technology has been well established for the last 20 years. Recently research has begun to emerge into its potential uses in the detection and diagnosis of pre-malignant and malignant cond...

    Authors: Angela A. Pathiraja, Ruwan A. Weerakkody, Alexander C. von Roon, Paul Ziprin and Richard Bayford

    Citation: Journal of Translational Medicine 2020 18:227

    Content type: Review

    Published on:

  41. Docetaxel (DTX) is a widely used anti-tumour drug, and its dosage is solely determined by body surface area (BSA). Adverse events, such as neutropenia or unsatisfied efficacy, likely occur because of differenc...

    Authors: Ning Sun, Bo Shen, Jiali Zhu, Xiaomei Zhang, Huayun Zhu, Geyu Liang, Deliang Yang, Jianwei Lu and Yan Zhang

    Citation: Journal of Translational Medicine 2020 18:226

    Content type: Research

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  42. Fibrosis is the formation of excess connective tissue in an organ or tissue during a reparative or reactive process. Graft-versus-host disease (GvHD) is a medical complication of allogeneic tissue transplantat...

    Authors: Jaeyoon Ryu, Jooyeon Jhun, Min-Jung Park, Jin-ah Baek, Se-Young Kim, Keun-Hyung Cho, Jeong-Won Choi, Sung-Hwan Park, Jong Young Choi and Mi-La Cho

    Citation: Journal of Translational Medicine 2020 18:225

    Content type: Research

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  43. Radiation-induced oral mucositis (OM) is one of the most common acute complications for head and neck cancer. Severe OM is associated with radiation treatment breaks, which harms successful tumor management. R...

    Authors: Da-Wei Yang, Tong-Min Wang, Jiang-Bo Zhang, Xi-Zhao Li, Yong-Qiao He, Ruowen Xiao, Wen-Qiong Xue, Xiao-Hui Zheng, Pei-Fen Zhang, Shao-Dan Zhang, Ye-Zhu Hu, Guo-Ping Shen, Mingyuan Chen, Ying Sun and Wei-Hua Jia

    Citation: Journal of Translational Medicine 2020 18:224

    Content type: Research

    Published on:

  44. Cervical cancer (CC) represents the fourth most frequently diagnosed malignancy affecting women all over the world. However, effective prognostic biomarkers are still limited for accurately identifying high-ri...

    Authors: Yimin Li, Shun Lu, Mei Lan, Xinhao Peng, Zijian Zhang and Jinyi Lang

    Citation: Journal of Translational Medicine 2020 18:223

    Content type: Research

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  45. COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effe...

    Authors: Giovanni Salvatori, Laura Luberto, Mariano Maffei, Luigi Aurisicchio, Giuseppe Roscilli, Fabio Palombo and Emanuele Marra

    Citation: Journal of Translational Medicine 2020 18:222

    Content type: Commentary

    Published on:

  46. During early pregnancy, tolerance of the semi-allogeneic fetus necessitates comprehensive modifications of the maternal immune system. How decidual CD8+T (CD8+dT) cells balance maternal tolerance of the fetus wit...

    Authors: Lu Liu, Xixi Huang, Chunfang Xu, Chunqin Chen, Weijie Zhao, Dajin Li, Liping Li, Li Wang and Meirong Du

    Citation: Journal of Translational Medicine 2020 18:221

    Content type: Research

    Published on:

  47. Previous studies have shown clinical relevance of programmed death-ligand 1 (PD-L1) and soluble PD-L1 (sPD-L1) in human cancers. However, still contradictory results exist. Our aim was evaluation of PD-L1-expr...

    Authors: Karolina Okła, Alicja Rajtak, Arkadiusz Czerwonka, Marcin Bobiński, Anna Wawruszak, Rafał Tarkowski, Wiesława Bednarek, Justyna Szumiło and Jan Kotarski

    Citation: Journal of Translational Medicine 2020 18:220

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2020 18:258

  48. The outbreak of the novel coronavirus disease 2019 (COVID-19) and consequent social distancing practices have disrupted essential clinical research functions worldwide. Ironically, this coincides with an immed...

    Authors: Iman Osman, Paolo Cotzia, Una Moran, Douglas Donnelly, Carolina Arguelles-Grande, Sandra Mendoza and Andre Moreira

    Citation: Journal of Translational Medicine 2020 18:219

    Content type: Commentary

    Published on:

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