Articles

The association of priori and posteriori dietary patterns with the risk of incident hypertension: Tehran Lipid and Glucose Study

The aim of this study was to investigate the association of dietary patterns with incident hypertension.

Authors: Azra Ramezankhani, Firoozeh Hosseini-Esfahani, Parvin Mirmiran, Fereidoun Azizi and Farzad Hadaegh

Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response

Epidermal growth factor receptor (EGFR) is frequently amplified or overexpressed in head and neck squamous cell carcinoma (HNSCC) and is a clinically validated target for the therapeutic antibody, cetuximab, i...

Authors: Sean P. Korpela, Trista K. Hinz, Ayman Oweida, Jihye Kim, Jacob Calhoun, Robert Ferris, Raphael A. Nemenoff, Sana D. Karam, Eric T. Clambey and Lynn E. Heasley

HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia

IGHV mutation status is a crucial prognostic biomarker for CLL. In the present study, we investigated the transcriptomic signatures associating with IGHV mutation status and CLL prognosis.

Authors: Chao Guo, Ya-yue Gao, Qian-qian Ju, Chun-xia Zhang, Ming Gong and Zhen-ling Li

Assessing the clinical utility of genetic risk scores for targeted cancer screening

Genome-wide association studies have identified thousands of disease-associated single nucleotide polymorphisms (SNPs). A subset of these SNPs may be additively combined to generate genetic risk scores (GRSs) ...

Authors: Carly A. Conran, Zhuqing Shi, William Kyle Resurreccion, Rong Na, Brian T. Helfand, Elena Genova, Siqun Lilly Zheng, Charles B. Brendler and Jianfeng Xu

Patient-derived organoid (PDO) platforms to facilitate clinical decision making

Based on recent advances in organoid research as well as the need to find more accurate models for drug screening in cancer research, patient-derived organoids have emerged as an effective in vitro model syste...

Authors: Lisa Liu, Lei Yu, Zhichao Li, Wujiao Li and WeiRen Huang

Blood-based extracellular matrix biomarkers as predictors of survival in patients with metastatic pancreatic ductal adenocarcinoma receiving pegvorhyaluronidase alfa

Extensive extracellular matrix (ECM) remodeling is a hallmark of metastatic pancreatic ductal adenocarcinoma (mPDA). We investigated fragments of collagen types III (C3M, PRO-C3), VI (PRO-C6), and VIII (C8-C),...

Authors: Song Wang, Cecilie L. Bager, Morten A. Karsdal, Dimitrios Chondros, Darin Taverna and Nicholas Willumsen

Distinct osmoregulatory responses to sodium loading in patients with altered glycosaminoglycan structure: a randomized cross-over trial

By binding to negatively charged polysaccharides called glycosaminoglycans, sodium can be stored in the body—particularly in the skin—without concurrent water retention. Concordantly, individuals with changed ...

Authors: Eliane F. E. Wenstedt, Jetta J. Oppelaar, Stijn Besseling, Nienke M. G. Rorije, Rik H. G. Olde Engberink, Arie Oosterhof, Toin H. van Kuppevelt, Bert-Jan H. van den Born, Jan Aten and Liffert Vogt

Reduction of miR-744 delivered by NSCLC cell-derived extracellular vesicles upregulates SUV39H1 to promote NSCLC progression via activation of the Smad9/BMP9 axis

Non-small cell lung cancer (NSCLC) is a common type of lung cancer. Extracellular vehicles (EVs) are nano-sized particles containing proteins, lipids, and miRNAs secreted by various cells, which play important...

Authors: Liming Gao, Qi Tian, Tong Wu, Shanshan Shi, Xiaobo Yin, Lijie Liu, Lei Zheng, Ping Wang, Yaling Tian and Shufeng Xu

Accuracy of the end-expiratory lung volume measured by the modified nitrogen washout/washin technique: a bench study

The functional residual capacity (FRC) determines the oxygenating capacity of the lung and is heavily affected in the clinical context of the acute respiratory distress syndrome. Nitrogen-wash-in/wash-out meth...

Authors: Joana Berger-Estilita, Matthias Haenggi, Daniel Ott and David Berger

Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis

Systemic lupus erythematosus (SLE) is a multisystemic, chronic inflammatory disease characterized by destructive systemic organ involvement, which could cause the decreased functional capacity, increased morbi...

Authors: Xingwang Zhao, Longlong Zhang, Juan Wang, Min Zhang, Zhiqiang Song, Bing Ni and Yi You

Alteration of transthyretin and thyroxine-binding globulin in major depressive disorder: multiple reaction monitoring-based proteomic analysis

Major depressive disorder (MDD), common mental disorder, lacks objective diagnostic and prognosis biomarkers. The objective of this study was to perform proteomic analysis to identify proteins with changed exp...

Authors: Hye In Woo, Jisook Park, Shinn-Won Lim, Doh Kwan Kim and Soo-Youn Lee

Optimization of the Mainzelliste software for fast privacy-preserving record linkage

Data analysis for biomedical research often requires a record linkage step to identify records from multiple data sources referring to the same person. Due to the lack of unique personal identifiers across the...

Authors: Florens Rohde, Martin Franke, Ziad Sehili, Martin Lablans and Erhard Rahm

Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2

Although it is becoming evident that individual’s immune system has a decisive influence on SARS-CoV-2 disease progression, pathogenesis is largely unknown. In this study, we aimed to profile the host transcri...

Authors: Abul Bashar Mir Md. Khademul Islam, Md. Abdullah-Al-Kamran Khan, Rasel Ahmed, Md. Sabbir Hossain, Shah Md. Tamim Kabir, Md. Shahidul Islam and A. M. A. M. Zonaed Siddiki

Transcriptomic analysis identifies organ-specific metastasis genes and pathways across different primary sites

Metastasis is the most devastating stage of cancer progression and often shows a preference for specific organs.

Authors: Lin Zhang, Ming Fan, Francesco Napolitano, Xin Gao, Ying Xu and Lihua Li

Analysis of viral load in different specimen types and serum antibody levels of COVID-19 patients

COVID-19 has caused a global pandemic and the death toll is increasing. However, there is no definitive information regarding the type of clinical specimens that is the best for SARS-CoV-2 detection, the antib...

Authors: Ling Li, Chianru Tan, Jia Zeng, Chen Luo, Shi Hu, Yanke Peng, Wenjuan Li, Zhixiong Xie, Yueming Ling, Xuejun Zhang, E. Deng, Haixia Xu, Jue Wang, Yudi Xie, Yaling Zhou, Wei Zhang…

CT radiomics facilitates more accurate diagnosis of COVID-19 pneumonia: compared with CO-RADS

Limited data was available for rapid and accurate detection of COVID-19 using CT-based machine learning model. This study aimed to investigate the value of chest CT radiomics for diagnosing COVID-19 pneumonia ...

Authors: Huanhuan Liu, Hua Ren, Zengbin Wu, He Xu, Shuhai Zhang, Jinning Li, Liang Hou, Runmin Chi, Hui Zheng, Yanhong Chen, Shaofeng Duan, Huimin Li, Zongyu Xie and Dengbin Wang

Systematic review and meta-analysis of the prognostic significance of microRNAs related to metastatic and EMT process among prostate cancer patients

The ability of tumor cells to spread from their origin place and form secondary tumor foci is determined by the epithelial–mesenchymal transition process. In epithelial tumors such as prostate cancer (PCa), th...

Authors: Martyna Parol, Arkadiusz Gzil, Magdalena Bodnar and Dariusz Grzanka

Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients

KRAS gene is the most common type of mutation reported in colorectal cancer (CRC). KRAS mutation-mediated regulation of immunophenotype and immune pathways in CRC remains to be elucidated.

Authors: Jungang Liu, Xiaoliang Huang, Haizhou Liu, Chunyin Wei, Haiming Ru, Haiquan Qin, Hao Lai, Yongsheng Meng, Guo Wu, Weishun Xie, Xianwei Mo, Caroline H. Johnson, Yawei Zhang and Weizhong Tang

Model based on five tumour immune microenvironment-related genes for predicting hepatocellular carcinoma immunotherapy outcomes

Although the tumour immune microenvironment is known to significantly influence immunotherapy outcomes, its association with changes in gene expression patterns in hepatocellular carcinoma (HCC) during immunot...

Authors: Xinyu Gu, Jun Guan, Jia Xu, Qiuxian Zheng, Chao Chen, Qin Yang, Chunhong Huang, Gang Wang, Haibo Zhou, Zhi Chen and Haihong Zhu

The risk and added values of the atherosclerotic cardiovascular risk enhancers on prediction of cardiovascular events: Tehran lipid and glucose study

In 2013 American College of Cardiology and the American Heart Association released a guideline on the management of atherosclerotic cardiovascular disease (ASCVD) including a composite of death from CVD, non-f...

Authors: Farzad Hadaegh, Samaneh Asgari, Fatemeh Moosaie, Meysam Orangi, Farzaneh Sarvghadi, Davood Khalili and Fereidoun Azizi

Improvement of urinary tract symptoms and quality of life in benign prostate hyperplasia patients associated with consumption of a newly developed whole tomato-based food supplement: a phase II prospective, randomized double-blinded, placebo-controlled study

Benign prostatic hyperplasia (BPH) is the most common urologic disease among elderly men. The diagnosis of BPH is usually driven by lower urinary tract symptoms (LUTS) that can significantly affect patients’ q...

Authors: Luigi Cormio, Beppe Calò, Ugo Falagario, Manuela Iezzi, Alessia Lamolinara, Paola Vitaglione, Giovanni Silecchia, Giuseppe Carrieri, Vincenzo Fogliano, Stefano Iacobelli, Pier Giorgio Natali and Mauro Piantelli

Anti-migraine agents from an immunological point of view

The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs. CGRP, whil...

Authors: Bakri M. Assas

Development of nomogram based on immune-related gene FGFR4 for advanced non-small cell lung cancer patients with sensitivity to immune checkpoint inhibitors

Immune checkpoint inhibitors (ICIs) have become a frontier in the field of clinical technology for advanced non-small cell lung cancer (NSCLC). Currently, the predictive biomarker of ICIs mainly including the ...

Authors: Li Wang, Zhixuan Ren, Bentong Yu and Jian Tang

Validation of a method evaluating T cell metabolic potential in compliance with ICH Q2 (R1)

Metabolic cell features are able to give reliable information on cell functional state. Thus, metabolic potential assessment of T cells in malignancy setting represents a promising area, especially in adoptive...

Authors: Patricia Mercier-Letondal, Chrystel Marton, Yann Godet and Jeanne Galaine

An analytical method for the identification of cell type-specific disease gene modules

Genome-wide association studies have identified genetic variants associated with the risk of brain-related diseases, such as neurological and psychiatric disorders, while the causal variants and the specific v...

Authors: Jinting Guan, Yiping Lin, Yang Wang, Junchao Gao and Guoli Ji

Effect of a novel functional tomato sauce (OsteoCol) from vine-ripened tomatoes on serum lipids in individuals with common hypercholesterolemia: tomato sauce and hypercholesterolemia

Most studies focused on the benefits of lycopene on serum lipids but no studies have been specifically designed to assess the role of a tomato sauce from vine-ripened tomatoes on patients affected by polygenic...

Authors: Yvelise Ferro, Elisa Mazza, Elvira Angotti, Roberta Pujia, Angela Mirarchi, Maria Antonietta Salvati, Rosa Terracciano, Rocco Savino, Stefano Romeo, Antonio Scuteri, Rosario Mare, Francesco Saverio Costanzo, Arturo Pujia and Tiziana Montalcini

Three hematologic/immune system-specific expressed genes are considered as the potential biomarkers for the diagnosis of early rheumatoid arthritis through bioinformatics analysis

Rheumatoid arthritis (RA) is the most common chronic autoimmune connective tissue disease. However, early RA is difficult to diagnose due to the lack of effective biomarkers. This study aimed to identify new b...

Authors: Qi Cheng, Xin Chen, Huaxiang Wu and Yan Du

A monocentric phase I study of vemurafenib plus cobimetinib plus PEG-interferon (VEMUPLINT) in advanced melanoma patients harboring the V600BRAF mutation

Studies carried out in vitro and in a mouse model have shown that BRAF inhibitors enhance the effects of IFN-α on BRAFV600E melanoma cells through the inhibition of ERK. Therefore, the combination of vemurafenib ...

Authors: Ester Simeone, Giosuè Scognamiglio, Mariaelena Capone, Diana Giannarelli, Antonio M. Grimaldi, Domenico Mallardo, Gabriele Madonna, Marcello Curvietto, Assunta Esposito, Fabio Sandomenico, Francesco Sabbatino, Nicholas L. Bayless, Sarah Warren, SuFey Ong, Gerardo Botti, Keith T. Flaherty…

Amniotic fluid-derived multipotent stromal cells drive diabetic wound healing through modulation of macrophages

Cutaneous wounds in patients with diabetes exhibit impaired healing due to physiological impediments and conventional care options are severely limited. Multipotent stromal cells (MSCs) have been touted as a p...

Authors: Bibi S. Subhan, Jennifer Kwong, Joseph F. Kuhn, Arie Monas, Sonali Sharma and Piul S. Rabbani

Qualitative and quantitative comparison of cell-free DNA and cell-free fetal DNA isolation by four (semi-)automated extraction methods: impact in two clinical applications: chimerism quantification and noninvasive prenatal diagnosis

Non-invasive molecular analysis of cell-free DNA (cfDNA) became a sensitive biomarker for monitoring organ transplantation or for detection of fetal DNA (cffDNA) in noninvasive prenatal test. In this study, we...

Authors: Pascal Pedini, Hajer Graiet, Laurine Laget, Lugdivine Filosa, Jade Chatron, Nicem Cherouat, Jacques Chiaroni, Lucas Hubert, Coralie Frassati and Christophe Picard

Titanium-interlayer mediated hydroxyapatite coating on polyetheretherketone: a prospective study in patients with single-level cervical degenerative disc disease

Currently, there are limited reports regarding investigation of the biological properties of polyetheretherketone (PEEK) coated with titanium (Ti) and hydroxyapatite (HA) in human. The objective of this study ...

Authors: Ce Zhu, Miaomiao He, Lili Mao, Tao Li, Li Zhang, Limin Liu, Ganjun Feng and Yueming Song

Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge” (December 4th–5th, 2019, Naples, Italy)

Over the last few years, numerous clinical trials and real-world experience have provided a large amount of evidence demonstrating the potential for long-term survival with immunotherapy agents across various ...

Authors: Paolo A. Ascierto, Lisa H. Butterfield, Katie Campbell, Bruno Daniele, Michael Dougan, Leisha A. Emens, Silvia Formenti, Filip Janku, Samir N. Khleif, Tomas Kirchhoff, Alessandro Morabito, Yana Najjar, Paul Nathan, Kunle Odunsi, Akash Patnaik, Chrystal M. Paulos…

PGM5-AS1 impairs miR-587-mediated GDF10 inhibition and abrogates progression of prostate cancer

Prostate cancer (PCa) is a leading cause of cancer-related death in males. Aberrant expression of long non-coding RNAs (lncRNAs) has been implicated in various human malignancies, including PCa. This study aim...

Authors: Lei Du and Yongli Gao

Immune responses to azacytidine in animal models of inflammatory disorders: a systematic review

Inflammatory disorders like diabetes, systemic lupus erythematodes, inflammatory lung diseases, rheumatoid arthritis and multiple sclerosis, but also rejection of transplanted organs and GvHD, form a major bur...

Authors: Sija Landman, Chiel van der Horst, Piet E. J. van Erp, Irma Joosten, Rob de Vries and Hans J. P. M. Koenen

Deep learning model for classifying endometrial lesions

Hysteroscopy is a commonly used technique for diagnosing endometrial lesions. It is essential to develop an objective model to aid clinicians in lesion diagnosis, as each type of lesion has a distinct treatmen...

Authors: YunZheng Zhang, ZiHao Wang, Jin Zhang, CuiCui Wang, YuShan Wang, Hao Chen, LuHe Shan, JiaNing Huo, JiaHui Gu and Xiaoxin Ma

Hypoxia and the phenomenon of immune exclusion

Over the last few years, cancer immunotherapy experienced tremendous developments and it is nowadays considered a promising strategy against many types of cancer. However, the exclusion of lymphocytes from the...

Authors: Violena Pietrobon and Francesco M. Marincola

Exosomal LncRNA LINC00659 transferred from cancer-associated fibroblasts promotes colorectal cancer cell progression via miR-342-3p/ANXA2 axis

Cancer-associated fibroblasts (CAFs) play a pivotal role in regulating tumor progression by transferring exosomes to adjacent cells. Our aim was to clarify the role of LINC00659 encapsulated in CAFs-derived ex...

Authors: Lin Zhou, Jian Li, Yaping Tang and Mei Yang

Genomic profile of metastatic breast cancer patient-derived xenografts established using percutaneous biopsy

Metastatic breast cancer (mBC) is a complex and life-threatening disease and although it is difficult to cure, patients can benefit from sequential anticancer treatment, including endocrine therapy, targeted t...

Authors: Seongyeong Kim, Dongjin Shin, Ahrum Min, Minjung Kim, Deukchae Na, Han-Byeol Lee, Han Suk Ryu, Yaewon Yang, Go-Un Woo, Kyung-Hun Lee, Dae-Won Lee, Tae-Yong Kim, Charles Lee, Seock-Ah Im and Jong-Il Kim

Multi-omic signatures of atherogenic dyslipidaemia: pre-clinical target identification and validation in humans

Dyslipidaemia is a major risk factor for atherosclerosis and cardiovascular diseases. The molecular mechanisms that translate dyslipidaemia into atherogenesis and reliable markers of its progression are yet to...

Authors: Mariola Olkowicz, Izabela Czyzynska-Cichon, Natalia Szupryczynska, Renata B. Kostogrys, Zdzislaw Kochan, Janusz Debski, Michal Dadlez, Stefan Chlopicki and Ryszard T. Smolenski

A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma

The tumor immunological microenvironment (TIME) has a prominent impact on prognosis and immunotherapy. However, the heterogeneous TIME and the mechanisms by which TIME affects immunotherapy have not been eluci...

Authors: Zaoqu Liu, Yuyuan Zhang, Chengcheng Shi, Xueliang Zhou, Kaihao Xu, Dechao Jiao, Zhenqiang Sun and Xinwei Han

Extracellular vesicle-encapsulated microRNA-424 exerts inhibitory function in ovarian cancer by targeting MYB

Recent studies have suggested a crucial role of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) in ovarian cancer treatment. We, therefore, set out to explore the mechanism through which MSC-d...

Authors: Ping Li, Hongyan Xin and Lili Lu

Effects of time-restricted feeding in weight loss, metabolic syndrome and cardiovascular risk in obese women

The increasing prevalence of overweight and obesity among the worldwide population has been associated with a range of adverse health consequences such as Type 2 diabetes and cardiovascular diseases. The metab...

Authors: Jéssica D. Schroder, Hugo Falqueto, Aline Mânica, Daniela Zanini, Tácio de Oliveira, Clodoaldo A. de Sá, Andréia Machado Cardoso and Leandro Henrique Manfredi

Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump

Treating severe forms of the acute respiratory distress syndrome and cardiac failure, extracorporeal membrane oxygenation (ECMO) has become an established therapeutic option. Neonatal or pediatric patients rec...

Authors: Malte Schöps, Sascha H. Groß-Hardt, Thomas Schmitz-Rode, Ulrich Steinseifer, Daniel Brodie, Johanna C. Clauser and Christian Karagiannidis

The evidence base for physiotherapy in myalgic encephalomyelitis/chronic fatigue syndrome when considering post-exertional malaise: a systematic review and narrative synthesis

Due to the inconsistent use of diagnostic criteria in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), it is unsure whether physiotherapeutic management regarded effective in ME/CFS is appropriate ...

Authors: Marjon E. A. Wormgoor and Sanne C. Rodenburg

Design of a companion bioinformatic tool to detect the emergence and geographical distribution of SARS-CoV-2 Spike protein genetic variants

Tracking the genetic variability of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) is a crucial challenge. Mainly to identify target sequences in order to generate robust vaccines and neutralizin...

Authors: Alice Massacci, Eleonora Sperandio, Lorenzo D’Ambrosio, Mariano Maffei, Fabio Palombo, Luigi Aurisicchio, Gennaro Ciliberto and Matteo Pallocca

Parkinson’s disease following COVID-19: causal link or chance occurrence?

Authors: Wei-Shan Li, Ling-Ling Chan, Yin-Xia Chao and Eng-King Tan

Correction to: Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)

An amendment to this paper has been published and can be accessed via the original article.

Authors: Do-Young Kim, Jin-Seok Lee, Samuel-Young Park, Soo-Jin Kim and Chang-Gue Son

Correction to: The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition

An amendment to this paper has been published and can be accessed via the original article.

Authors: Junfeng Sun, Chaohui Ding, Zhen Yang, Tao Liu, Xiefu Zhang, Chunlin Zhao and Jiaxiang Wang

COVID-19 biomarkers for severity mapped to polycystic ovary syndrome

Authors: Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin and Alexandra E. Butler

May the analysis of 1918 influenza pandemic give hints to imagine the possible magnitude of Corona Virus Disease-2019 (COVID-19)?

In 1918 an unknown infectious agent spread around the world infecting over one-third of the general population and killing almost 50 million people. Many countries were at war, the First World War. Since Spain...

Authors: Raffaele Scarpa, Francesco Caso, Luisa Costa, Saverio Passavanti, Maria Grazia Vitale, Claudia Trojaniello, Antonio Del Puente and Paolo A. Ascierto