Articles

Chimeric antigen receptor T-cell therapy in glioblastoma: charging the T cells to fight

Glioblastoma multiforme (GBM) is the most common malignant brain cancer that invades normal brain tissue and impedes surgical eradication, resulting in early local recurrence and high mortality. In addition, m...

Authors: Craig A. Land, Phillip R. Musich, Dalia Haydar, Giedre Krenciute and Qian Xie

Bronchoalveolar Tregs are associated with duration of mechanical ventilation in acute respiratory distress syndrome

Foxp3⁺ regulatory T cells (Tregs) play essential roles in immune homeostasis and repair of damaged lung tissue. We hypothesized that patients whose lung injury resolves quickly, as measured by time to liberation ...

Authors: Dustin L. Norton, Agathe Ceppe, Miriya K. Tune, Matthew McCravy, Thomas Devlin, M. Bradley Drummond, Shannon S. Carson, Benjamin G. Vincent, Robert S. Hagan, Hong Dang, Claire M. Doerschuk and Jason R. Mock

Determinants of placental iodine concentrations in a mild-to-moderate iodine-deficient population: an ENVIRONAGE cohort study

Iodine is an essential trace element for the production of thyroid hormones, and plays a key role during the gestational period for optimal foetal growth and (neuro-)development. To this day, iodine deficiency...

Authors: Kristof Y. Neven, Bianca Cox, Karen Vrijens, Michelle Plusquin, Harry A. Roels, Ann Ruttens and Tim S. Nawrot

A brief guide to the science and art of writing manuscripts in biomedicine

Publishing articles in international scientific journals is the primary method for the communication of validated research findings and ideas. Journal articles are commonly used as a major input for evaluation...

Authors: Diego A. Forero, Sandra Lopez-Leon and George Perry

OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma

Diffuse intrinsic pontine glioma (DIPG) is the most common brainstem cancer in childhood. This rapidly progressing brainstem glioma holds a very dismal prognosis with median survival of less than 1 year. Despi...

Authors: Lincy Thomas, Nataliya Smith, Debra Saunders, Michelle Zalles, Rafal Gulej, Megan Lerner, Kar-Ming Fung, Angel M. Carcaboso and Rheal A. Towner

Accurate and objective determination of myalgic encephalomyelitis/chronic fatigue syndrome disease severity with a wearable sensor

Approximately 2.5 million people in the U.S. suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This disease negatively impacts patients’ ability to function, often resulting in difficult...

Authors: Turner Palombo, Andrea Campos, Suzanne D. Vernon and Shad Roundy

Investigation of circulating lncRNAs as potential biomarkers in chronic respiratory diseases

In the present study the blood expression level of inflammatory response and autoimmunity associated long non-coding RNAs (lncRNAs) were compared in patients with different chronic respiratory diseases and inv...

Authors: Zsófia Gál, András Gézsi, Ágnes F. Semsei, Adrienne Nagy, Monika Sultész, Zsuzsanna Csoma, Lilla Tamási, Gabriella Gálffy and Csaba Szalai

Revealing oral microbiota composition and functionality associated with heavy cigarette smoking

Heavy tobacco smoking, a hallmark feature of lung cancer, is drastically predominant in Middle Eastern populations. The precise links between nicotine dependence and the functional contribution of the oral mic...

Authors: Mohammad Tahseen Al Bataineh, Nihar Ranjan Dash, Mohammed Elkhazendar, Dua’a Mohammad Hasan Alnusairat, Islam Mohammad Ismail Darwish, Mohamed Saleh Al-Hajjaj and Qutayba Hamid

Transcriptome analysis identifies putative multi-gene signature distinguishing benign and malignant pancreatic head mass

Most often, the patients with pancreatic diseases are presented with a mass in pancreatic head region and existing methods of diagnosis fail to confirm whether the head mass is malignant or benign. As subseque...

Authors: Bishnupriya Chhatriya, Moumita Mukherjee, Sukanta Ray, Barsha Saha, Somdatta Lahiri, Sandip Halder, Indranil Ghosh, Sujan Khamrui, Kshaunish Das, Samsiddhi Bhattacharjee, Saroj Kant Mohapatra and Srikanta Goswami

Low-volume high-intensity interval training improves cardiometabolic health, work ability and well-being in severely obese individuals: a randomized-controlled trial sub-study

Obesity is associated with impaired health and lower work ability. Increased physical activity is a cornerstone in the treatment of obesity and related risk factors. Recently, high-intensity interval training ...

Authors: Dejan Reljic, Fabienne Frenk, Hans J. Herrmann, Markus F. Neurath and Yurdagül Zopf

Identification of cancer stem cell-related biomarkers in intestinal-type and diffuse-type gastric cancer by stemness index and weighted correlation network analysis

Cancer stem cells (CSCs) play an important role in drug resistance, recurrence, and metastasis of tumors. Considering the heterogeneity of tumors, this study aimed to explore the key genes regulating stem cell...

Authors: Rui Guo, Aining Chu and Yuehua Gong

Expanded circulating follicular dendritic cells facilitate immune responses in chronic HBV infection

The restoration of host hepatitis B virus (HBV)-specific antiviral immunity is an effective strategy for hepatitis B recovery. Follicular dendritic cells (FDCs) play a crucial role in immune regulation. The go...

Authors: Xiaoyi Li, Qifan Zhang, Wanyue Zhang, Guofu Ye, Yanchen Ma, Chunhua Wen, Shuqin Gu, Libo Tang and Yongyin Li

Molecular characterization of breast cancer: a potential novel immune-related lncRNAs signature

Accumulating evidence has demonstrated that immune-related lncRNAs (IRLs) are commonly aberrantly expressed in breast cancer (BC). Thus, we aimed to establish an IRL-based tool to improve prognosis prediction ...

Authors: Jianguo Lai, Bo Chen, Guochun Zhang, Xuerui Li, Hsiaopei Mok and Ning Liao

COVID-19: Is there a role for immunonutrition in obese patient?

On December 12, 2019 a new coronavirus (SARS-CoV-2) emerged in Wuhan, China, triggering a pandemic of severe acute respiratory syndrome in humans (COVID-19). Today, the scientific community is investing all th...

Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Claudia Leggeri, Giulia Cinelli, Maria Grazia Tarsitano, Giovanna Caparello, Elena Carrano, Giuseppe Merra, Alberto Maria Pujia, Roberta Danieli and Antonino De Lorenzo

Glycemic variability: prognostic impact on acute ischemic stroke and the impact of corrective treatment for hyperglycemia. The GLIAS-III translational study

Glycemic variability (GV) represents the amplitude of oscillations in glucose levels over time and is associated with higher mortality in critically ill patients. Our aim is to evaluate the impact of GV on acu...

Authors: Blanca Fuentes, Silvia Pastor-Yborra, Raquel Gutiérrez-Zúñiga, Noemí González-Pérez de Villar, Elena de Celis, Jorge Rodríguez-Pardo, Mari Carmen Gómez-de Frutos, Fernando Laso-García, María Gutiérrez-Fernández, MÁngeles Ortega-Casarrubios, Alfonso Soto, María López-Fernández, María Santamaría, Noemí Díez-González, Mar M. Freijo, Beatriz Zandio…

Cancer associated macrophage-like cells and prognosis of esophageal cancer after chemoradiation therapy

Cancer Associated Macrophage-Like cells (CAMLs) are polynucleated circulating stromal cells found in the bloodstream of numerous solid-tumor malignancies. Variations within CAML size have been associated with ...

Authors: Daniel J. Gironda, Daniel L. Adams, Jianzhong He, Ting Xu, Hui Gao, Yawei Qiao, Ritsuko Komaki, James M. Reuben, Zhongxing Liao, Mariela Blum-Murphy, Wayne L. Hofstetter, Cha-Mei Tang and Steven H. Lin

Detection of novel coronavirus (SARS-CoV-2) RNA in peripheral blood specimens

The latest outbreak of pneumonia caused by SARS-CoV-2 presents a significant challenge to global public health and has a major impact on clinical microbiology laboratories. In some situations, such as patients...

Authors: Marjan Azghandi and Mohammad Amin Kerachian

Necessity for detection of SARS-CoV-2 RNA in multiple types of specimens for the discharge of the patients with COVID-19

The SARS-CoV-2 RNA was detected positive again after discharged from hospital in some COVID-19 patients, with or without clinical symptoms such as fever or dry cough.

Authors: Yongqing Tong, Anyu Bao, Hongbing Chen, Jingtao Huang, Zhihua Lv, Lina Feng, Yun Cheng, Youna Wang, Li Bai, Wenlong Rao, Hongyun Zheng, Zegang Wu, Bin Qiao, Zhijun Zhao, Huiming Wang and Yan Li

Alteration of physical activity during COVID-19 pandemic lockdown in young adults

Authors: Bruno C. Huber, Julius Steffen, Jenny Schlichtiger, Tanja Graupe, Eileen Deuster, Victoria P. Strouvelle, Martin R. Fischer, Steffen Massberg and Stefan Brunner

Association of hypertension and hypertriglyceridemia on incident hyperuricemia: an 8-year prospective cohort study

Hypertension and high triglyceride are two of the most important risk factors for hyperuricemia. Epidemiological records show that hypertension and dyslipidemia often coexist and may significantly increase the...

Authors: Yuan Zhang, Miaomiao Zhang, Xiawen Yu, Fengjiang Wei, Chen Chen, Kai Zhang, Shuzhi Feng, Yaogang Wang and Wei-Dong Li

Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era

COronaVIrus Disease 19 (COVID-19) is caused by the infection of the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Although the main clinical manifestations of COVID-19 are respiratory, many pat...

Authors: S. Greco, A. Madè, C. Gaetano, Y. Devaux, C. Emanueli and F. Martelli

Serum interleukin-6 is an indicator for severity in 901 patients with SARS-CoV-2 infection: a cohort study

Interleukin-6 (IL-6) was proposed to be associated with the severity of coronavirus disease 2019 (COVID-19). The present study aimed to explore the kinetics of IL-6 levels, validate this association in COVID-1...

Authors: Jing Zhang, Yiqun Hao, Wuling Ou, Fei Ming, Gai Liang, Yu Qian, Qian Cai, Shuang Dong, Sheng Hu, Weida Wang and Shaozhong Wei

Correction to: A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease

An amendment to this paper has been published and can be accessed via the original article.

Authors: Sean Holden, Rebekah Maksoud, Natalie Eaton-Fitch, Hélène Cabanas, Donald Staines and Sonya Marshall-Gradisnik

Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial

Tocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients.

Authors: Francesco Perrone, Maria Carmela Piccirillo, Paolo Antonio Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M. Marrocco-Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, Maria Lorenza Muiesan, Miriam Lichtner…

Hypoxia directed migration of human naïve monocytes is associated with an attenuation of cytokine release: indications for a key role of CCL26

Numerous tissue-derived factors have been postulated to be involved in tissue migration of circulating monocytes. The aim of this study was to evaluate whether a defined hypoxic gradient can induce directed mi...

Authors: Lars Hummitzsch, Rouven Berndt, Matthias Kott, Rene Rusch, Fred Faendrich, Matthias Gruenewald, Markus Steinfath, Martin Albrecht and Karina Zitta

Quantitative sensory phenotyping in chronic neuropathic pain patients treated with unilateral L4-dorsal root ganglion stimulation

In a previous study, we reported that selective dorsal root ganglion stimulation (DRG_STIM) at DRG level L4 promoted a favorable outcome for complex regional pain syndrome (CRPS) patients along with DRG_STIM-relate...

Authors: Thomas Kinfe, Nico von Willebrand, Andreas Stadlbauer, Michael Buchfelder, Thomas L. Yearwood, Sajjad Muhammad, Shafqat R. Chaudhry, Sascha Gravius, Thomas Randau, Klemens Winder, Christian Maihöfner, Nadine Gravius and Walter Magerl

In vivo vaccination with cell line-derived whole tumor lysates: neoantigen quality, not quantity matters

Cancer vaccines provide a complex source of neoantigens. Still, increasing evidence reveals that the neoantigen quality rather than the quantity is predictive for treatment outcome.

Authors: Inken Salewski, Yvonne Saara Gladbach, Steffen Kuntoff, Nina Irmscher, Olga Hahn, Christian Junghanss and Claudia Maletzki

Early evidence of efficacy for orally administered SPM-enriched marine lipid fraction on quality of life and pain in a sample of adults with chronic pain

Marine lipids contain omega-3 fatty acids that can be metabolized into anti-inflammatory and pro-resolving mediators—namely 17-HDHA and 18-HEPE—which can serve as modulators of the pain experience. The purpose...

Authors: Nini Callan, Doug Hanes and Ryan Bradley

Contrast-induced nephropathy and oxidative stress: mechanistic insights for better interventional approaches

Contrast-induced nephropathy (CIN) or contrast-induced acute kidney injury (CI-AKI) is an iatrogenic acute kidney injury observed after intravascular administration of contrast media for intravascular diagnost...

Authors: Prit Kusirisin, Siriporn C. Chattipakorn and Nipon Chattipakorn

Mesenchymal stromal cells for osteonecrosis

Osteonecrosis (ON) is an acquired debilitating skeletal disorder, which is caused by a multitude of traumatic and non-traumatic etiological factors. Vascular damage, mechanical stress and increased intraosseou...

Authors: S. Elgaz, H. Bonig and P. Bader

Allogeneic administration of human umbilical cord-derived mesenchymal stem/stromal cells for bronchopulmonary dysplasia: preliminary outcomes in four Vietnamese infants

Bronchopulmonary dysplasia (BPD) is a severe condition in premature infants that compromises lung function and necessitates oxygen support. Despite major improvements in perinatal care minimizing the devastati...

Authors: Liem Thanh Nguyen, Thai T. H. Trieu, Hue T. H. Bui, Van T. Hoang, Anh T. T. Nguyen, Nhung T. H. Trinh, Kien T. Nguyen and Duc M. Hoang

Effect of early prophylactic low-dose recombinant human erythropoietin on retinopathy of prematurity in very preterm infants

Very preterm infants are at risk of developing retinopathy of prematurity (ROP). Recombinant human erythropoietin (rhEPO) is routinely used to prevent anemia in preterm infants; however, the effect of rhEPO on...

Authors: Huiqing Sun, Juan Song, Wenqing Kang, Yong Wang, Xiantao Sun, Chongchen Zhou, Hong Xiong, Falin Xu, Mingchao Li, Xiaoli Zhang, Zengyuan Yu, Xirui Peng, Bingbing Li, Yiran Xu, Shan Xing, Xiaoyang Wang…

Leptin mediate central obesity on the severity of cardiovascular autonomic neuropathy in well-controlled type 2 diabetes and prediabetes

Evidences support the view that central obesity is an independently cardiovascular risk. It is thought that leptin contributes to autonomic dysfunction and cardiovascular risks in type 1 and type 2 diabetes me...

Authors: Yun-Ru Lai, Meng Hsiang Chen, Wei Che Lin, Wen-Chan Chiu, Ben-Chung Cheng, Jung-Fu Chen, Nai-Wen Tsai, Chih-Cheng Huang and Cheng-Hsien Lu

High Smad7 in the early post-operative recurrence of Crohn’s disease

In Crohn’s disease (CD), one of the major inflammatory bowel disease (IBD) in human beings, there is over-expression of Smad7, an intracellular inhibitor of the suppressive cytokine TGF-β1. The aim of this stu...

Authors: Francesca Zorzi, Emma Calabrese, Davide Di Fusco, Elena De Cristofaro, Livia Biancone, Sara Casella, Giampiero Palmieri and Giovanni Monteleone

Designing and piloting a generic research architecture and workflows to unlock German primary care data for secondary use

Medical data from family doctors are of great importance to health care researchers but seem to be locked in German practices and, thus, are underused in research. The RADAR project (Routine Anonymized Data fo...

Authors: Thomas Bahls, Johannes Pung, Stephanie Heinemann, Johannes Hauswaldt, Iris Demmer, Arne Blumentritt, Henriette Rau, Johannes Drepper, Philipp Wieder, Roland Groh, Eva Hummers and Falk Schlegelmilch

Connecting METTL3 and intratumoural CD33⁺ MDSCs in predicting clinical outcome in cervical cancer

Methyltransferase-like 3 (METTL3) is a member of the m⁶A methyltransferase family and acts as an oncogene in cancers. Recent studies suggest that host innate immunity is regulated by the enzymes controlling m⁶A e...

Authors: Huan-he Ni, Lin Zhang, He Huang, Shu-qin Dai and Jiang Li

Classification models using circulating neutrophil transcripts can detect unruptured intracranial aneurysm

Intracranial aneurysms (IAs) are dangerous because of their potential to rupture. We previously found significant RNA expression differences in circulating neutrophils between patients with and without unruptu...

Authors: Kerry E. Poppenberg, Vincent M. Tutino, Lu Li, Muhammad Waqas, Armond June, Lee Chaves, Kaiyu Jiang, James N. Jarvis, Yijun Sun, Kenneth V. Snyder, Elad I. Levy, Adnan H. Siddiqui, John Kolega and Hui Meng

LTBP1 plays a potential bridge between depressive disorder and glioblastoma

Glioblastoma multiforme (GBM) is the most malignant tumor in human brain. Diagnosis and treatment of GBM may lead to psychological disorders such as depressive and anxiety disorders. There was no research focu...

Authors: Xiaojun Fu, Pei Zhang, Hongwang Song, Chenxing Wu, Shengzhen Li, Shouwei Li and Changxiang Yan

A painful lesson from the COVID-19 pandemic: the need for broad-spectrum, host-directed antivirals

While the COVID-19 pandemic has spurred intense research and collaborative discovery worldwide, the development of a safe, effective, and targeted antiviral from the ground up is time intensive. Therefore, mos...

Authors: Vipul C. Chitalia and Ali H. Munawar

rs2476601 in PTPN22 gene in rheumatoid arthritis and periodontitis—a possible interface?

Rheumatoid arthritis (RA) and periodontitis (PD) are proven to share common risk markers, including genetic factors. In the present study we focused on genetic variants in PTPN22 (rs2476601), PADI4 (rs2240340), C...

Authors: Susanne Schulz, Pauline Zimmer, Natalie Pütz, Elisa Jurianz, Hans-Günter Schaller and Stefan Reichert

Bioinformatic gene analysis for potential therapeutic targets of Huntington’s disease in pre-symptomatic and symptomatic stage

Huntington’s disease (HD) is a neurodegenerative disorder characterized by psychiatric symptoms, serious motor and cognitive deficits. Certain pathological changes can already be observed in pre-symptomatic HD...

Authors: Chunchen Xiang, Shengri Cong, Bin Liang and Shuyan Cong

Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: a pilot study

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease of unknown etiology lasting for a minimum of 6 months but usually for many years, with features including fatigue, cognitiv...

Authors: Ludovic Giloteaux, Adam O’Neal, Jesús Castro-Marrero, Susan M. Levine and Maureen R. Hanson

Endometrial cancer: mapping the global landscape of research

From a global viewpoint, endometrial cancer belongs to the most common female cancers. Despite the heavy burden of diseases and numerous unanswered questions, no detailed pictures of the global structure of en...

Authors: Dörthe Brüggmann, Katja Ouassou, Doris Klingelhöfer, Michael K. Bohlmann, Jenny Jaque and David A. Groneberg

Association between telomere length in peripheral blood leukocytes and risk of ischemic stroke in a Han Chinese population: a linear and non-linear Mendelian randomization analysis

Many contradictory conclusions pertaining to the telomere length in peripheral leukocyte chromosomes as a potential biomarker for ischemic stroke (IS) risk have been reported by the various observational studi...

Authors: Weijie Cao, Deqiang Zheng, Jie Zhang, Anxin Wang, Di Liu, Jinxia Zhang, Manjot Singh, Isinta Elijah Maranga, Mingyang Cao, Lijuan Wu, Manshu Song, Wei Wang and Youxin Wang

Assessment of EN-RAGE, sRAGE and EN-RAGE/sRAGE as potential biomarkers in patients with autoimmune hepatitis

Autoimmune hepatitis (AIH) is a liver disease characterized by the autoimmune-induced injury of hepatocytes which can lead to cirrhosis and hepatic failure. The diagnosis and disease management of AIH patients...

Authors: Rui Wu, Yan Liu, Ruyu Yan, Xiaoyu Liu and Liang Duan

Closing the system: production of viral antigen-presenting dendritic cells eliciting specific CD8⁺ T cell activation in fluorinated ethylene propylene cell culture bags

A major obstacle to anti-viral and -tumor cell vaccination and T cell immunotherapy is the ability to produce dendritic cells (DCs) in a suitable clinical setting. It is imperative to develop closed cell cultu...

Authors: Jean-Philippe Bastien, Natalie Fekete, Ariane V. Beland, Marie-Paule Lachambre, Veronique Laforte, David Juncker, Vibhuti Dave, Denis-Claude Roy and Corinne A. Hoesli

Gut microbiota from coronary artery disease patients contributes to vascular dysfunction in mice by regulating bile acid metabolism and immune activation

The gut microbiota was shown to play a crucial role in the development of vascular dysfunction, and the bacterial composition differed between healthy controls and coronary artery disease patients. The goal of...

Authors: Honghong Liu, Ran Tian, Hui Wang, Siqin Feng, Hanyu Li, Ying Xiao, Xiaodong Luan, Zhiyu Zhang, Na Shi, Haitao Niu and Shuyang Zhang

Gene correlation network analysis to identify regulatory factors in sepsis

Sepsis is a leading cause of mortality and morbidity in the intensive care unit. Regulatory mechanisms underlying the disease progression and prognosis are largely unknown. The study aimed to identify master r...

Authors: Zhongheng Zhang, Lin Chen, Ping Xu, Lifeng Xing, Yucai Hong and Pengpeng Chen

Changes in lipid composition associated with electronic cigarette use

Electronic cigarette use is on the rise despite a number of reports linking electronic cigarettes with adverse health outcomes. Recent studies have suggested that alterations in lipid signaling may be one mech...

Authors: Holly R. Middlekauff, Kevin J. William, Baolong Su, Kacey Haptonstall, Jesus A. Araujo, Xiaohui Wu, Jason Kim and Tamer Sallam

A possible link to uracil DNA glycosylase in the synergistic action of HDAC inhibitors and thymidylate synthase inhibitors

It is well established that thymidylate synthase inhibitors can cause cellular toxicity through uracil DNA glycosylase (UNG2)-dependent pathways. Additionally, thymidylate synthase inhibitors and HDAC inhibito...

Authors: Meredith S. Showler and Brian P. Weiser