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  1. Recently, mesenchymal stem/stromal cells (MSCs) due to their pro-angiogenic, anti-apoptotic, and immunoregulatory competencies along with fewer ethical issues are presented as a rational strategy for regenerat...

    Authors: Soudeh Moghadasi, Marischa Elveny, Heshu Sulaiman Rahman, Wanich Suksatan, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Alexei Valerievich Yumashev, Siavash Shariatzadeh, Roza Motavalli, Farahnaz Behzad, Faroogh Marofi, Ali Hassanzadeh, Yashwant Pathak and Mostafa Jarahian

    Citation: Journal of Translational Medicine 2021 19:302

    Content type: Review

    Published on:

  2. Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with molecular heterogeneity, inducing differences in biological behavior, and therapeutic strategy. NGS profiles of pathogenic alterations in the Chi...

    Authors: Lin Shui, Xiaofen Li, Yang Peng, Jiangfang Tian, Shuangshuang Li, Du He, Ang Li, Bole Tian, Mao Li, Heli Gao, Ning An, Cheng Yi and Dan Cao

    Citation: Journal of Translational Medicine 2021 19:301

    Content type: Research

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    The Correction to this article has been published in Journal of Translational Medicine 2021 19:345

  3. The coronavirus disease 2019 (COVID-19) pandemic has struck globally and is exerting a devastating toll on humans. The pandemic has led to calls for widespread vitamin D supplementation in public. However, evi...

    Authors: Zhiyong Cui and Yun Tian

    Citation: Journal of Translational Medicine 2021 19:300

    Content type: Research

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  4. Diabetic nephropathy (DN) has an increasing global prevalence with excessive health expenditure and burden. Exosomal mRNAs regulate intercellular communications and participate in the pathogenesis of various d...

    Authors: Ehsan Hashemi, Hojat Dehghanbanadaki, Alireza Abbasi Baharanchi, Katayoon Forouzanfar, Ardeshir Kakaei, Seyed Mohammad Mohammadi, Saba Zeidi and Farideh Razi

    Citation: Journal of Translational Medicine 2021 19:299

    Content type: Research

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  5. Nonradiographic axial spondyloarthropathies (nr-axSpA) are diagnosed by the absence of radiographic sacroiliitis and the presence of bone marrow edema (BME) on magnetic resonance imaging (MRI). According to th...

    Authors: Chun-Chi Lu, Guo-Shu Huang, Tony Szu-Hsien Lee, En Chao, Hsiang-Cheng Chen, Yong-Si Guo, Shi-Jye Chu, Feng-Cheng Liu, San-Yuan Kao, Tsung-Yun Hou, Chen-Hung Chen, Deh-Ming Chang and Sin-Yi Lyu

    Citation: Journal of Translational Medicine 2021 19:298

    Content type: Research

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  6. The glutathione S-transferase P1(GSTP1) is an isoenzyme in the glutathione-S transferases (GSTs) enzyme system, which is the most abundant GSTs expressed in adult lungs. Recent research shows that GSTP1 is clo...

    Authors: Xiao Lei, Lehui Du, Wei Yu, Yao Wang, Na Ma and Baolin Qu

    Citation: Journal of Translational Medicine 2021 19:297

    Content type: Review

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  7. Immunotherapy is a revolutionary strategy in cancer therapy, but the resistance of which is one of the important challenges. Detecting the regulation of immune cells and biomarkers concerning immune checkpoint...

    Authors: Jingwen Wang, Feng Li, Yanjun Xu, Xuan Zheng, Chunlong Zhang, Congxue Hu, Yingqi Xu, Wanqi Mi, Xia Li and Yunpeng Zhang

    Citation: Journal of Translational Medicine 2021 19:296

    Content type: Research

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  8. Metastasis and invasion are crucial in determining the mortality of cervical carcinoma (CC) patients. The epithelial–mesenchymal transition (EMT) is now a universal explanation for the mechanisms of tumor meta...

    Authors: Haoqi Zhao, Lan Wang, Shufang Wang, Xihua Chen, Min Liang, Xin Zhang, Jiedong Wang and Xiangbo Xu

    Citation: Journal of Translational Medicine 2021 19:295

    Content type: Research

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  9. This is the first study to build and evaluate a predictive model for early relapse after R0 resection in hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI).

    Authors: Kai Zhang, Changcheng Tao, Tana Siqin, Jianxiong Wu and Weiqi Rong

    Citation: Journal of Translational Medicine 2021 19:293

    Content type: Research

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  10. Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiol...

    Authors: Knut Sindre Mølmen, Daniel Hammarström, Gunnar Slettaløkken Falch, Morten Grundtvig, Lise Koll, Marita Hanestadhaugen, Yusuf Khan, Rafi Ahmad, Bente Malerbakken, Tore Jørgen Rødølen, Roger Lien, Bent R. Rønnestad, Truls Raastad and Stian Ellefsen

    Citation: Journal of Translational Medicine 2021 19:292

    Content type: Research

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  11. Heart failure (HF) with preserved ejection fraction (HFpEF) is a leading cause of hospitalizations and mortality when diagnosed at the age of ≥ 65 years. HFpEF represents multifactorial and multisystemic syndr...

    Authors: Ying Lin, Shihui Fu, Yao Yao, Yulong Li, Yali Zhao and Leiming Luo

    Citation: Journal of Translational Medicine 2021 19:291

    Content type: Review

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  12. We performed a prospective multicentre diagnostic study to evaluate the combined interferon-γ (IFN-γ) and interleukin-2 (IL-2) release assay for detect active pulmonary tuberculosis (TB) in China.

    Authors: Yaoju Tan, Yunhong Tan, Junlian Li, Pengnan Hu, Ping Guan, Haobin Kuang, Qide Liang, Yanyan Yu, Zhongnan Chen, Quan Wang, Zhenping Yang, DiLiNaZi AiKeReMu, Yu Pang and Jianxiong Liu

    Citation: Journal of Translational Medicine 2021 19:289

    Content type: Research

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  13. This study aimed to establish and validate an easy-to-operate novel scoring system based on simple and readily available clinical indices for predicting the progression of chronic kidney disease (CKD).

    Authors: Qian Xu, Yunyun Wang, Yiqun Fang, Shanshan Feng, Cuiyun Chen and Yanxia Jiang

    Citation: Journal of Translational Medicine 2021 19:288

    Content type: Research

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  14. Reversible enzymatic methylation of mammalian mRNA is widespread and serves crucial regulatory functions, but little is known to what degree chemical alkylators mediate overlapping modifications and whether ce...

    Authors: Kristian Lied Wollen, Lars Hagen, Cathrine B. Vågbø, Renana Rabe, Tobias S. Iveland, Per Arne Aas, Animesh Sharma, Bjørnar Sporsheim, Hilde O. Erlandsen, Vuk Palibrk, Magnar Bjørås, Davi M. Fonseca, Nima Mosammaparast and Geir Slupphaug

    Citation: Journal of Translational Medicine 2021 19:287

    Content type: Research

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  15. Understanding the distinct patterns (trajectories) of variation in blood lipid levels before diagnosing cardiovascular disease (CVD) might carry important implications for improving disease prevention or treat...

    Authors: Fatemeh Koohi, Davood Khalili, Mohammad Ali Mansournia, Farzad Hadaegh and Hamid Soori

    Citation: Journal of Translational Medicine 2021 19:286

    Content type: Research

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  16. An accurate prediction for prognosis can help in guiding the therapeutic options and optimizing the trial design for generalized myasthenia gravis (gMG). We aimed to develop and validate a predictive nomogram ...

    Authors: Rui Zhao, Ying Wang, Xiao Huan, Huahua Zhong, Zhirui Zhou, Jianying Xi, Yuwei Da, Lin Lei, Ting Chang, Zhe Ruan, Lijun Luo, Shengnan Li, Huan Yang, Yi Li, Sushan Luo and Chongbo Zhao

    Citation: Journal of Translational Medicine 2021 19:285

    Content type: Research

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  17. The association between serum advanced oxidation protein products (AOPP) and mortality risk remains equivocal. We aimed to assess the correlation of serum AOPP levels with the risk of all-cause mortality in he...

    Authors: Chun Zhou, Yuanyuan Zhang, Jianghua Chen, Changlin Mei, Fei Xiong, Wei Shi, Wei Zhou, Xusheng Liu, Shiren Sun, Jianwei Tian, Ziliang Ye, Qimeng Wu, Xianhui Qin, Jianping Jiang and Fan Fan Hou

    Citation: Journal of Translational Medicine 2021 19:284

    Content type: Research

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  18. Epithelial-mesenchymal transition (EMT) of mesothelial cells is a key step in the peritoneal fibrosis (PF). Recent evidence indicates that signal transducer and activator of transcription 3 (STAT3) might media...

    Authors: Xiaoxiao Yang, Manchen Bao, Yi Fang, Xiaofang Yu, Jun Ji and Xiaoqiang Ding

    Citation: Journal of Translational Medicine 2021 19:283

    Content type: Research

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  19. Surgical resection is the only potentially curative treatment for pancreatic ductal adenocarcinoma (PDAC) and the survival of patients after radical resection is closely related to relapse. We aimed to develop...

    Authors: Xiawei Li, Litao Yang, Zheping Yuan, Jianyao Lou, Yiqun Fan, Aiguang Shi, Junjie Huang, Mingchen Zhao and Yulian Wu

    Citation: Journal of Translational Medicine 2021 19:281

    Content type: Research

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  20. Colorectal cancer is the third most common diagnosis. Oxaliplatin is used as first-line treatment of colon cancer. However, oxaliplatin resistance greatly reduces its therapeutic effect. SRPK1 involves in pre-...

    Authors: Jing-Qiang Huang, He-Feng Li, Jing Zhu, Jun-Wei Song, Xian-Bin Zhang, Peng Gong, Qiu-Yu Liu, Chun-Hui Zhou, Liang Wang and Li-Yun Gong

    Citation: Journal of Translational Medicine 2021 19:280

    Content type: Research

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  21. Metabolic reprograming have been associated with cancer occurrence and progression within the tumor immune microenvironment. However, the prognostic potential of metabolism-related genes in colorectal cancer (...

    Authors: Dagui Lin, Wenhua Fan, Rongxin Zhang, Enen Zhao, Pansong Li, Wenhao Zhou, Jianhong Peng and Liren Li

    Citation: Journal of Translational Medicine 2021 19:279

    Content type: Research

    Published on:

  22. Advances in immune checkpoint therapy and targeted therapy have led to improvement in overall survival for patients with advanced melanoma. Single agent checkpoint PD-1 blockade and combination with BRAF/MEK t...

    Authors: Paolo A. Ascierto, Christian Blank, Reinhard Dummer, Marc S. Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Patrick Hwu, Pawel Kalinski, Michelle Krogsgaard, Roger S. Lo, Jason J. Luke, Bart Neyns, Michael A. Postow, Sergio A. Quezada…

    Citation: Journal of Translational Medicine 2021 19:278

    Content type: Meeting report

    Published on:

  23. Fasting plasma glucose (FPG) and 2-h post challenge plasma glucose (2 h-PCPG), whether as continuous or categorical variables, are associated with incident cardiovascular disease (CVD) and diabetes; however, t...

    Authors: Maryam Kabootari, Samaneh Asgari, Seyedeh Maryam Ghavam, Hengameh Abdi, Fereidoun Azizi and Farzad Hadaegh

    Citation: Journal of Translational Medicine 2021 19:277

    Content type: Research

    Published on:

  24. Dental implants are considered the gold standard replacement for missing natural teeth. The successful clinical performance of dental implants is due to their ability to osseointegrate with the surrounding bon...

    Authors: Noura M. AlOtaibi, Michael Dunne, Ashraf F. Ayoub and Kurt B. Naudi

    Citation: Journal of Translational Medicine 2021 19:276

    Content type: Research

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  25. There is a huge body of scientific literature describing the relation between tumor types and anti-cancer drugs. The vast amount of scientific literature makes it impossible for researchers and physicians to e...

    Authors: Chris Bauer, Ralf Herwig, Matthias Lienhard, Paul Prasse, Tobias Scheffer and Johannes Schuchhardt

    Citation: Journal of Translational Medicine 2021 19:274

    Content type: Research

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  26. The identification of novel functional biomarkers is essential for recognizing high-risk patients, predicting recurrence, and searching for appropriate treatment. However, no prognostic biomarker has been appl...

    Authors: Wei Zhang, Liewen Lin, Ligang Xia, Wanxia Cai, Weier Dai, Chang Zou, Lianghong Yin, Donge Tang, Yong Xu and Yong Dai

    Citation: Journal of Translational Medicine 2021 19:273

    Content type: Research

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  27. Recent studies proposed the whole-blood based IFN-γ-release assay to study the antigen-specific SARS-CoV-2 response. Since the early prediction of disease progression could help to assess the optimal treatment...

    Authors: Elisa Petruccioli, Saeid Najafi Fard, Assunta Navarra, Linda Petrone, Valentina Vanini, Gilda Cuzzi, Gina Gualano, Luca Pierelli, Antonio Bertoletti, Emanuele Nicastri, Fabrizio Palmieri, Giuseppe Ippolito and Delia Goletti

    Citation: Journal of Translational Medicine 2021 19:272

    Content type: Research

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  28. The favourable safety profile and the increasing confidence with immune checkpoint inhibitors (ICIs) might have boosted their prescription in frail patients with short life expectancies, who usually are not tr...

    Authors: Daniele Santini, Tea Zeppola, Marco Russano, Fabrizio Citarella, Cecilia Anesi, Sebastiano Buti, Marco Tucci, Alessandro Russo, Maria Chiara Sergi, Vincenzo Adamo, Luigia S. Stucci, Melissa Bersanelli, Giulia Mazzaschi, Francesco Spagnolo, Francesca Rastelli, Francesca Chiara Giorgi…

    Citation: Journal of Translational Medicine 2021 19:270

    Content type: Research

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  29. In order to correctly decode phenotypic information from RNA-sequencing (RNA-seq) data, careful selection of the RNA-seq quantification measure is critical for inter-sample comparisons and for downstream analy...

    Authors: Yingdong Zhao, Ming-Chung Li, Mariam M. Konaté, Li Chen, Biswajit Das, Chris Karlovich, P. Mickey Williams, Yvonne A. Evrard, James H. Doroshow and Lisa M. McShane

    Citation: Journal of Translational Medicine 2021 19:269

    Content type: Research

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  30. Obstructive sleep apnea (OSA), a sleep disorder frequently observed in individuals living with obesity, consists of repeated involuntary breathing obstructions during sleep, leading to intermittent hypoxia (IH...

    Authors: Renée Morin, Jean-François Mauger, Ruwan Amaratunga and Pascal Imbeault

    Citation: Journal of Translational Medicine 2021 19:268

    Content type: Research

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  31. Biobanking is an area of scientific activity that is growing in strength and importance. The variety of collections combining biological samples and medical scientific information makes biobanking an indispens...

    Authors: Anna Chróścicka, Angelika Paluch, Łukasz Kozera and Małgorzata Lewandowska-Szumieł

    Citation: Journal of Translational Medicine 2021 19:267

    Content type: Research

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  32. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jeonghyeon Moon, Seon-yeong Lee, Jeong Won Choi, A. Ram Lee, Jin Hee Yoo, Su-Jin Moon, Sung-Hwan Park and Mi-La Cho

    Citation: Journal of Translational Medicine 2021 19:266

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2021 19:192

  33. Genetically engineered chimeric antigen receptor (CAR) T lymphocytes are promising therapeutic tools for cancer. Four CAR T cell drugs, including tisagenlecleucel (tisa-cel) and axicabtagene-ciloleucel (axi-ce...

    Authors: Rafik Haderbache, Walid Warda, Eric Hervouet, Mathieu Neto da Rocha, Rim Trad, Vincent Allain, Clementine Nicod, Catherine Thieblemeont, Nicolas Boissel, Pauline Varlet, Ibrahim Yakoub Agha, Lucie Bouquet, Melanie Guiot, Fabienne Venet, Pierre Sujobert, Xavier Roussel…

    Citation: Journal of Translational Medicine 2021 19:265

    Content type: Methodology

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  34. Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been implicated in the progression of esophageal cancer (EC). However, the specific mechanism of the involvement of MEG3 in EC development in...

    Authors: Qi-Rong Xu, Jian Tang, Hong-Ying Liao, Ben-Tong Yu, Xiang-Yuan He, Yu-Zhen Zheng and Sheng Liu

    Citation: Journal of Translational Medicine 2021 19:264

    Content type: Research

    Published on:

  35. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jie Yao, Zefen Wang, Yong Cheng, Chao Ma, Yahua Zhong, Yilei Xiao, Xu Gao and Zhiqiang Li

    Citation: Journal of Translational Medicine 2021 19:263

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2021 19:99

  36. Sickle cell disease (SCD) is commonly encountered in Africa and Middle Eastern countries. The causative mutation in the gene encoding the hemoglobin subunit β (HBB) leads to various genotypic variants of the d...

    Authors: Ibrahim Khamees, Fateen Ata, Hassan Choudry, Ashraf T. Soliman, Vincenzo De Sanctis and Mohamed A. Yassin

    Citation: Journal of Translational Medicine 2021 19:262

    Content type: Review

    Published on:

  37. Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has been implicated in immunoglobulin (Ig)E activation of mast cells (MCs) via high-affinity I...

    Authors: Hui-Na Wang, Kunmei Ji, Li-Na Zhang, Chu-Chu Xie, Wei-Yong Li, Zhen-Fu Zhao and Jia-Jie Chen

    Citation: Journal of Translational Medicine 2021 19:261

    Content type: Research

    Published on:

  38. Asthma is a frequently occurring respiratory disease with an increasing incidence around the world. Airway inflammation and remodeling are important contributors to the occurrence of asthma. We conducted this ...

    Authors: Wendi Wei, Weida Chen and Naifeng He

    Citation: Journal of Translational Medicine 2021 19:258

    Content type: Research

    Published on:

  39. We aimed to develop a radiomic model based on pre-treatment computed tomography (CT) to predict the pathological complete response (pCR) in patients with rectal cancer after neoadjuvant treatment and tried to ...

    Authors: Zhuokai Zhuang, Zongchao Liu, Juan Li, Xiaolin Wang, Peiyi Xie, Fei Xiong, Jiancong Hu, Xiaochun Meng, Meijin Huang, Yanhong Deng, Ping Lan, Huichuan Yu and Yanxin Luo

    Citation: Journal of Translational Medicine 2021 19:256

    Content type: Research

    Published on:

  40. Recent studies reporting the intricate crosstalk between cellular and molecular mediators and the lymphatic endothelium in the development of inflammatory bowel diseases (IBD) suggest altered inflammatory cell...

    Authors: Dickson Kofi Wiredu Ocansey, Bing Pei, Xinwei Xu, Lu Zhang, Chinasa Valerie Olovo and Fei Mao

    Citation: Journal of Translational Medicine 2021 19:254

    Content type: Review

    Published on:

  41. Polycystic kidney disease (PKD) is a common renal disorder affecting approximately 1 in 1000 live births. Tuberculosis (TB) is an infectious disease worldwide. This study investigated the risk of TB infection ...

    Authors: Ting-Fang Chiu, Tung-Min Yu, Chih-Wei Chiu, Brian K. Lee, Tsuo-Hung Lan, Chi-Yuan Li, Mei-Chen Lin and Chia-Hung Kao

    Citation: Journal of Translational Medicine 2021 19:253

    Content type: Research

    Published on:

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