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  1. Duchenne muscular dystrophy (DMD) is an X-linked inherited disease caused by mutations in the gene encoding dystrophin that leads to a severe and ultimately life limiting muscle-wasting condition. Recombinant ...

    Authors: Anna Creisméas, Claire Gazaille, Audrey Bourdon, Marc-Antoine Lallemand, Virginie François, Marine Allais, Mireille Ledevin, Thibaut Larcher, Gilles Toumaniantz, Aude Lafoux, Corinne Huchet, Ignacio Anegon, Oumeya Adjali, Caroline Le Guiner and Bodvaël Fraysse
    Citation: Journal of Translational Medicine 2021 19:519
  2. Over the past decade, human Interleukin 33 (hIL-33) has emerged as a key contributor to the pathogenesis of numerous inflammatory diseases. Despite the existence of several commercial hIL-33 assays spanning mu...

    Authors: Elaine Mai, Joyce Chan, Levina Goon, Braeden K. Ego, Jack Bevers, Tiffany Wong, Manda Wong, Racquel Corpuz, Hongkang Xi, Jia Wu, Kellen Schneider, Dhaya Seshasayee, Michele Grimbaldeston, Gerald Nakamura, Vahan B. Indjeian, Menno van Lookeren Campagne…
    Citation: Journal of Translational Medicine 2021 19:517
  3. Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment, have prominent roles in the development of solid tumors as stromal targets. However, the underlying mechanism of CAF...

    Authors: Jia-Yi Zhang, Wei-Wen Zhu, Meng-Yao Wang, Run-Dong Zhai, Qiong Wang, Wei-Li Shen and Lai-Kui Liu
    Citation: Journal of Translational Medicine 2021 19:513
  4. Association between blood pressure (BP) and kidney function among the middle and old aged general population without hypertension remains unclear.

    Authors: Huai-yu Wang, Qinqin Meng, Chao Yang, Yafeng Wang, Guilan Kong, Yaohui Zhao, Fang Wang and Luxia Zhang
    Citation: Journal of Translational Medicine 2021 19:512
  5. Necrotizing enterocolitis (NEC) remains a life-threatening disease in neonates. Numerous studies have shown a correlation between the intestinal microbiota and NEC, but the causal link remains unclear. This study...

    Authors: Yu He, Weixia Du, Sa Xiao, Benhua Zeng, Xiang She, Dong Liu, Hua Du, Luquan Li, Fang Li, Qing Ai, Junli He, Chao Song, Hong Wei, Xiaodong Zhao and Jialin Yu
    Citation: Journal of Translational Medicine 2021 19:510
  6. Emerging evidence has revealed that some long intergenic non-coding RNAs (lincRNAs) are likely to form clusters on the same chromosome, and lincRNA genomic clusters might play critical roles in the pathophysio...

    Authors: Hanxiao Zhou, Yue Gao, Xin Li, Shipeng Shang, Peng Wang, Hui Zhi, Shuang Guo, Dailin Sun, Hongjia Liu, Xia Li, Yunpeng Zhang and Shangwei Ning
    Citation: Journal of Translational Medicine 2021 19:509
  7. Loss-of-function mutations or abnormal expressions of E ubiquitin ligases contributes to tumorigenesis. TRIM38 was reported to regulate immunity, inflammatory responses or apoptosis, but its roles in tumor pro...

    Authors: Xiaojing Wang, Hongchao He, Wenbin Rui, Ning Zhang, Yu Zhu and Xin Xie
    Citation: Journal of Translational Medicine 2021 19:508
  8. Reduced cardiovascular risk in premenopausal women has been the focus of research in recent decades. Previous hypothesis-driven experiments have highlighted the role of sex hormones on distinct inflammatory re...

    Authors: Bálint András Barta, Mihály Ruppert, Klemens Erwin Fröhlich, Miguel Cosenza-Contreras, Attila Oláh, Alex Ali Sayour, Krisztián Kovács, Gellért Balázs Karvaly, Martin Biniossek, Béla Merkely, Oliver Schilling and Tamás Radovits
    Citation: Journal of Translational Medicine 2021 19:507
  9. Knee osteoarthritis is the most prevalent joint disease and a frequent cause of pain, functional loss and disability. Conventional treatments have demonstrated only modest clinical benefits whereas cell-based ...

    Authors: José María Lamo-Espinosa, Felipe Prósper, Juan F. Blanco, Fermín Sánchez-Guijo, Mercedes Alberca, Verónica García, Margarita González-Vallinas and Javier García-Sancho
    Citation: Journal of Translational Medicine 2021 19:506
  10. LINC00491 was involved in some tumors development, but its function in liver cancer has not been reported. This study aimed to investigate LINC00491 expression and function in liver cancer progression.

    Authors: Wei Wang, Tao Yang, Dongsheng Li, Yinpeng Huang, Guang Bai and Qing Li
    Citation: Journal of Translational Medicine 2021 19:504
  11. Chronic fatigue syndrome (CFS) is a long-term disabling illness accompanied by medically unexplained fatigue. This study aimed to explore the epidemiological characteristics of CFS in South Korea.

    Authors: Eun-Jin Lim, Jin-Seok Lee, Eun-Jung Lee, Seok-Ju Jeong, Ho-Young Park, Yo-Chan Ahn and Chang-Gue Son
    Citation: Journal of Translational Medicine 2021 19:502
  12. Omics data, driven by rapid advances in laboratory techniques, have been generated very quickly during the COVID-19 pandemic. Our aim is to use omics data to highlight the involvement of specific pathways, as ...

    Authors: Chiara Montaldo, Francesco Messina, Isabella Abbate, Manuela Antonioli, Veronica Bordoni, Alessandra Aiello, Fabiola Ciccosanti, Francesca Colavita, Chiara Farroni, Saeid Najafi Fard, Emanuela Giombini, Delia Goletti, Giulia Matusali, Gabriella Rozera, Martina Rueca, Alessandra Sacchi…
    Citation: Journal of Translational Medicine 2021 19:501
  13. Diagnosing seronegative rheumatoid arthritis (RA) can be challenging due to complex diagnostic criteria. We sought to discover diagnostic biomarkers for seronegative RA cases by studying metabolomic and lipido...

    Authors: Hemi Luan, Wanjian Gu, Hua Li, Zi Wang, Lu Lu, Mengying Ke, Jiawei Lu, Wenjun Chen, Zhangzhang Lan, Yanlin Xiao, Jinyue Xu, Yi Zhang, Zongwei Cai, Shijia Liu and Wenyong Zhang
    Citation: Journal of Translational Medicine 2021 19:500
  14. Chimeric antigen receptor T cell (CAR-T cell) therapy is a relatively new, effective, and rapidly evolving therapeutic for adoptive immunotherapies. Although it has achieved remarkable effect in hematological ...

    Authors: Meng Zhang, Xin Jin, Rui Sun, Xia Xiong, Jiaxi Wang, Danni Xie and MingFeng Zhao
    Citation: Journal of Translational Medicine 2021 19:499
  15. Although the presence of physical signs [tendon xanthomas and/or corneal arcus (TX/CA)], are associated with the risk of coronary artery disease in patients with heterozygous familial hypercholesterolemia (HeF...

    Authors: Ming-Ming Liu, Jia Peng, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Qian Dong and Jian-Jun Li
    Citation: Journal of Translational Medicine 2021 19:498
  16. Immunotherapies targeting ligand-receptor interactions (LRIs) are advancing rapidly in the treatment of colorectal cancer (CRC), and LRIs also affect many aspects of CRC development. However, the pattern of LR...

    Authors: Hexin Lin, Lu Xia, Jiabian Lian, Yinan Chen, Yiyi Zhang, Zhicheng Zhuang, HuaJun Cai, Jun You and Guoxian Guan
    Citation: Journal of Translational Medicine 2021 19:497
  17. Pulmonary fibrosis is the end stage of a broad range of heterogeneous interstitial lung diseases and more than 200 factors contribute to it. In recent years, the relationship between virus infection and pulmon...

    Authors: Wei Jie Huang and Xiao Xiao Tang
    Citation: Journal of Translational Medicine 2021 19:496
  18. Comitant strabismus (CS) is a heterogeneous disorder that is a major contributing factor to unilateral childhood-onset visual impairment. Studies have confirmed that genetic factors play an important role in t...

    Authors: Yue Wang, Xuejuan Chen, Tao Jiang, Yayun Gu, Xiaohan Zhang, Wenwen Yuan, Andi Zhao, Rui Li, Zijin Wang, Zhibin Hu and Hu Liu
    Citation: Journal of Translational Medicine 2021 19:495
  19. The maintained attention is the cause of great functional limitations in CFS/ME, a disease that mainly affects women in the central period of life. Cognitive function is explored using the Montreal Cognitive A...

    Authors: Iñigo Murga, Larraitz Aranburu, Pascual A. Gargiulo, Juan-Carlos Gómez-Esteban and José-Vicente Lafuente
    Citation: Journal of Translational Medicine 2021 19:494
  20. To drive translational medicine, modern day biobanks need to integrate with other sources of data (clinical, genomics) to support novel data-intensive research. Currently, vast amounts of research and clinical...

    Authors: Rebecca Asiimwe, Stephanie Lam, Samuel Leung, Shanzhao Wang, Rachel Wan, Anna Tinker, Jessica N. McAlpine, Michelle M. M. Woo, David G. Huntsman and Aline Talhouk
    Citation: Journal of Translational Medicine 2021 19:493
  21. Prostate cancer (PCa) belongs to an epithelial malignancy that occurs in the prostate gland and is the most common malignancy of the male genitourinary system. Referring to related literature, circSERPINA3 has...

    Authors: Zengshu Xing, Sailian Li, Zhenxiang Liu, Chong Zhang and Zhiming Bai
    Citation: Journal of Translational Medicine 2021 19:492
  22. Nonthyroidal Illness Syndrome (NTIS) can be detected in many critical illnesses. Recently, we demonstrated that this condition is frequently observed in COVID-19 patients too and it is correlated with the seve...

    Authors: Salvatore Sciacchitano, Carlo Capalbo, Christian Napoli, Andrea Negro, Luciano De Biase, Adriano Marcolongo, Paolo Anibaldi, Valentina Salvati, Lea Petrella, Luca Merlo, Daniela Alampi, Elisa Alessandri, Chiara Loffredo, Alessandra Ulivieri, Luca Lavra, Fiorenza Magi…
    Citation: Journal of Translational Medicine 2021 19:491
  23. Fecal microbiota transplantation (FMT) is considered an effective treatment for slow transit constipation (STC); nevertheless, the mechanism remains unclear.

    Authors: Lulu Xie, Chen Xu, Yadong Fan, Yuwei Li, Ying Wang, Xiaoyu Zhang, Shuang Yu, Jida Wang, Rundong Chai, Zeyu Zhao, Yutong Jin, Zhe Xu, Shuwu Zhao and Yuhong Bian
    Citation: Journal of Translational Medicine 2021 19:490
  24. Overweight and obese patients with solid tumors receiving anti-programmed cell death-1 (PD-1)/PD-ligand-1(PD-L1) immune checkpoint inhibitors exhibit improved survival and higher risk of immune-related adverse ev...

    Authors: Rosaria De Filippi, Fortunato Morabito, Armando Santoro, Giovanni Tripepi, Francesco D’Alò, Luigi Rigacci, Francesca Ricci, Emanuela Morelli, Pier Luigi Zinzani and Antonio Pinto
    Citation: Journal of Translational Medicine 2021 19:489
  25. In recent years, the incidence rate of Thyroid carcinoma (TC) has been increasing worldwide. Thus, research on factors of TC carcinogenesis may promote TC prevention and decrease the incidence rate. There are ...

    Authors: Daofeng Dai, Yan Yang, Yong Yang, Tianfeng Dang, Jiansheng Xiao, Weibin Wang, Lisong Teng, Juan Xu, Jing Ye and Hongqun Jiang
    Citation: Journal of Translational Medicine 2021 19:488
  26. Epidermal growth factor receptor (EGFR)-mutant lung cancers have a high risk of developing brain metastases (BM). Whole brain radiotherapy (WBRT), local radiotherapy, and WBRT + Boost are frequently used for trea...

    Authors: Guangchuan Deng, Yingyun Zhang, Jiaojiao Ke, Qi Wang, Hongyue Qin, Jianbin Li and Zhenxiang Li
    Citation: Journal of Translational Medicine 2021 19:486

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:503

  27. Comparing the microbiome compositions obtained under different physiological conditions has frequently been attempted in recent years to understand the functional influence of microbiomes in the occurrence of ...

    Authors: Sukjung Choi, Jongsuk Chung, Mi-La Cho, Donghyun Park and Sun Shim Choi
    Citation: Journal of Translational Medicine 2021 19:485
  28. Secretory phospholipase A2 group IIA (sPLA2-IIA) is an independent risk factor for cardiovascular disease, but its role on high-density lipoprotein cholesterol (HDL-C) level has not been clarified. The aim of ...

    Authors: Ling Liang, Qiang Xie, Changqing Sun, Yuanhui Wu, Wei Zhang and Weihua Li
    Citation: Journal of Translational Medicine 2021 19:484
  29. The evaluation of translational health research is important for various reasons such as the research impact assessment, research funding allocation, accountability, and strategic research policy formulation. ...

    Authors: Vasiliki Kiparoglou, Laurence A. Brown, Helen McShane, Keith M. Channon and Syed Ghulam Sarwar Shah
    Citation: Journal of Translational Medicine 2021 19:483
  30. CAR T-cell therapy has been recently unveiled as one of the most promising cancer therapies in hematological malignancies. However, solid tumors mount a profound line of defense to escape immunosurveillance by...

    Authors: Khadijeh Alishah, Matthias Birtel, Elham Masoumi, Leila Jafarzadeh, Hamid Reza Mirzaee, Jamshid Hadjati, Ralf-Holger Voss, Mustafa Diken and Sedighe Asad
    Citation: Journal of Translational Medicine 2021 19:482
  31. Most head and neck cancer (HNC) patients receive radiotherapy (RT) and develop toxicities. This genome-wide association study (GWAS) was designed to identify single nucleotide polymorphisms (SNPs) associated w...

    Authors: Elnaz Naderi, Anne Petra Gerarda Crijns, Roel Johannes Henricus Marinus Steenbakkers, Johanna Geertruida Maria van den Hoek, Hendrika Marike Boezen, Behrooz Ziad Alizadeh and Johannes Albertus Langendijk
    Citation: Journal of Translational Medicine 2021 19:481
  32. The characterization of the immune component of the tumor microenvironment (TME) of human epidermal growth factor receptor 2 positive (HER2+) breast cancer has been limited. Molecular and spatial characterizat...

    Authors: Ilana Schlam, Sarah E. Church, Tyler D. Hether, Krysta Chaldekas, Briana M. Hudson, Andrew M. White, Emily Maisonet, Brent T. Harris and Sandra M. Swain
    Citation: Journal of Translational Medicine 2021 19:480
  33. Translational research is an ideology focussed on streamlining the transition of novel research into clinical practice to ultimately benefit populations. Central to this approach is overcoming barriers to rese...

    Authors: Justin B. Senecal, Karen Metcalfe, Kaila Wilson, Indryas Woldie and Lisa A. Porter
    Citation: Journal of Translational Medicine 2021 19:479
  34. Obesity is associated with chronic low-grade inflammation, contributing to an increasing prevalence of chronic metabolic diseases, such as insulin resistance, non-alcoholic fatty liver disease (NALFD), and ste...

    Authors: Jingchang Ma, Wei Hu, Dongliang Zhang, Jiangang Xie, Chujun Duan, Yitian Liu, Yuling Wang, Xuexue Xu, Kun Cheng, Boquan Jin, Yuan Zhang and Ran Zhuang
    Citation: Journal of Translational Medicine 2021 19:477
  35. MicroRNA-146a-5p (miR-146a-5p) is a key regulator of inflammatory processes. Expression of miR-146a-5p is altered in target organs of diabetic complications and deficiency of miR-146a-5p has been implicated in...

    Authors: Federica Barutta, Beatrice Corbetta, Stefania Bellini, Simonetta Guarrera, Giuseppe Matullo, Michela Scandella, Casper Schalkwijk, Coen D. Stehouwer, Nish Chaturvedi, Sabita S. Soedamah-Muthu, Marilena Durazzo and Gabriella Gruden
    Citation: Journal of Translational Medicine 2021 19:475
  36. Gene transfer is an important tool for cellular therapies. Lentiviral vectors are most effectively transferred into lymphocytes or hematopoietic progenitor cells using spinoculation. To enable cGMP (current Go...

    Authors: Victoria Ann Remley, Jianjian Jin, Sarmila Sarkar, Larry Moses, Michaela Prochazkova, Yihua Cai, Lipei Shao, Hui Liu, Tatyana Fuksenko, Ping Jin, David F. Stroncek and Steven L. Highfill
    Citation: Journal of Translational Medicine 2021 19:474
  37. The development of Bruton’s tyrosine kinase inhibitors (BTKi) for the treatment of chronic lymphocytic leukaemia (CLL) has provided a highly effective and relatively non-toxic alternative to conventional chemo...

    Authors: Joanne E. Davis, Chia Sharpe, Kylie Mason, Constantine S. Tam, Rachel M. Koldej and David S. Ritchie
    Citation: Journal of Translational Medicine 2021 19:473
  38. It is well known that malnutrition is a frequent co-morbidity in cancer patients, especially in those with head and neck neoplasms. This may be due both to the presence of dysphagia symptoms and to the appeara...

    Authors: Maria Giulia Cristofaro, Ida Barca, Francesco Ferragina, Daniela Novembre, Yvelise Ferro, Roberta Pujia and Tiziana Montalcini
    Citation: Journal of Translational Medicine 2021 19:472
  39. There is accumulating evidence of endothelial dysfunction, muscle and cerebral hypoperfusion in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In this paper we deduce the pathomechanisms resultin...

    Authors: Klaus J. Wirth, Carmen Scheibenbogen and Friedemann Paul
    Citation: Journal of Translational Medicine 2021 19:471

    The Correction to this article has been published in Journal of Translational Medicine 2022 20:25

    The Letter to the Editor to this article has been published in Journal of Translational Medicine 2022 20:40

  40. Nucleotide mutations in the ABO gene may reduce the activity of glycosyltransferase, resulting in lower levels of A or B antigen expression in red blood cells. Six known splice sites have been identified accordin...

    Authors: Xiaozhen Hong, Yanling Ying, Jingjing Zhang, Shu Chen, Xianguo Xu, Ji He and Faming Zhu
    Citation: Journal of Translational Medicine 2021 19:470
  41. Diabetes mellitus (DM), a most common chronic disease, is featured with impaired endothelial function and bioavailability of nitric oxide (NO), while E3 ubiquitin ligase appears to alleviate endothelial dysfun...

    Authors: Qingsong Jin, Liangyan Lin, Tiantian Zhao, Xiaoyan Yao, Yaqin Teng, Dongdong Zhang, Yongjun Jin and Meizi Yang
    Citation: Journal of Translational Medicine 2021 19:469
  42. Long non-coding RNAs (lncRNAs), functioning as competing endogenous RNAs (ceRNAs), have been reported to play important roles in the pathogenesis of autoimmune diseases. However, little is known about the regu...

    Authors: Shuang Li, Xu Wang, Tianfeng Wang, Huixue Zhang, Xiaoyu Lu, Li Liu, Lifang Li, Chunrui Bo, Xiaotong Kong, Si Xu, Shangwei Ning, Jianjian Wang and Lihua Wang
    Citation: Journal of Translational Medicine 2021 19:468
  43. Breast cancer remains one of the most dreadful female malignancies globally, in which cancer stem cells (CSCs) play crucial functions. Circular RNAs have drawn great attention in cancer research area and propo...

    Authors: Yi-Ping Liu, Jin-Yu Heng, Xin-Yu Zhao and En-You Li
    Citation: Journal of Translational Medicine 2021 19:467
  44. Despite the benefits of extracorporeal cardiopulmonary resuscitation (ECPR) in cohorts of selected patients with cardiac arrest (CA), extracorporeal membrane oxygenation (ECMO) includes an artificial oxygenati...

    Authors: Tai Yin, Lance B. Becker, Rishabh C. Choudhary, Ryosuke Takegawa, Muhammad Shoaib, Koichiro Shinozaki, Yusuke Endo, Koichiro Homma, Daniel M. Rolston, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Tomoaki Aoki, Santiago J. Miyara…
    Citation: Journal of Translational Medicine 2021 19:462

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