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  1. Research

    Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes

    Adipocytes derived from human mesenchymal stem cells (MSCs) are widely used to investigate adipogenesis. Taking into account both the novelty of these MSCs and the scarcity of studies focused on the effects of...

    Saioa Gómez-Zorita, Arrate Lasa, Naiara Abendaño, Alfredo Fernández-Quintela, Andrea Mosqueda-Solís, Maria Pilar Garcia-Sobreviela, Jose M. Arbonés-Mainar and Maria P. Portillo

    Journal of Translational Medicine 2017 15:237

    Published on: 21 November 2017

  2. Meeting report

    Future perspectives in melanoma research “Melanoma Bridge”, Napoli, November 30th–3rd December 2016

    Major advances have been made in the treatment of cancer with targeted therapy and immunotherapy; several FDA-approved agents with associated improvement of 1-year survival rates became available for stage IV ...

    Paolo A. Ascierto, Sanjiv S. Agarwala, Gennaro Ciliberto, Sandra Demaria, Reinhard Dummer, Connie P. M. Duong, Soldano Ferrone, Silvia C. Formenti, Claus Garbe, Ruth Halaban, Samir Khleif, Jason J. Luke, Lluis M. Mir, Willem W. Overwijk, Michael Postow, Igor Puzanov…

    Journal of Translational Medicine 2017 15:236

    Published on: 16 November 2017

  3. Research

    Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients

    Gene polymorphisms at microRNA-binding sites (poly-miRTS) may affect gene transcription and expression through miRNA regulation, which is associated with cancer susceptibility, sensitivity to chemotherapy and ...

    Hai-xia Cao, Chao-feng Miao, Liang Yan, Ping Tang, Li-rong Zhang and Ling Sun

    Journal of Translational Medicine 2017 15:235

    Published on: 15 November 2017

  4. Research

    The macrophage C-type lectin receptor CLEC5A (MDL-1) expression is associated with early plaque progression and promotes macrophage survival

    Biomarkers of early plaque progression are still elusive. Myeloid DAP12-associating lectin-1 (MDL-1), also called CLEC5A, is a C-type lectin receptor implicated in the progression of multiple acute and chronic...

    Weixin Xiong, Haibo Wang, Lin Lu, Rui Xi, Fang Wang, Gang Gu and Rong Tao

    Journal of Translational Medicine 2017 15:234

    Published on: 10 November 2017

  5. Research

    A murine model for developmental dysplasia of the hip: ablation of CX3CR1 affects acetabular morphology and gait

    Developmental dysplasia of the hip (DDH) is a debilitating condition whose distinguishing signs include incomplete formation of the acetabulum leading to dislocation of the femur, accelerated wear of the artic...

    George Feldman, Arlene Offemaria, Hind Sawan, Javad Parvizi and Theresa A. Freeman

    Journal of Translational Medicine 2017 15:233

    Published on: 10 November 2017

  6. Review

    Radioprotective agents to prevent cellular damage due to ionizing radiation

    Medical imaging has become a central component of patient care to ensure early and accurate diagnosis. Unfortunately, many imaging modalities use ionizing radiation to generate images. Ionizing radiation even ...

    Tyler A. Smith, Daniel R. Kirkpatrick, Sean Smith, Trevor K. Smith, Tate Pearson, Aparna Kailasam, Kortney Z. Herrmann, Johanna Schubert and Devendra K. Agrawal

    Journal of Translational Medicine 2017 15:232

    Published on: 9 November 2017

  7. Methodology

    GMP-production of purified human B lymphocytes for the adoptive transfer in patients after allogeneic hematopoietic stem cell transplantation

    We have recently shown that memory B cells from murine CMV immune donor animals adoptively transferred into immunodeficient mice were highly effective in protecting from a viral infection indicating a therapeu...

    Hannes Tittlbach, Andrea Schneider, Julian Strobel, Robert Zimmermann, Stefanie Maas, Bernd Gebhardt, Georg Rauser, Michael Mach, Andreas Mackensen, Thomas H. Winkler and Julia Winkler

    Journal of Translational Medicine 2017 15:228

    Published on: 7 November 2017

  8. Review

    Management and potentialities of primary cancer cultures in preclinical and translational studies

    The use of patient-derived primary cell cultures in cancer preclinical assays has increased in recent years. The management of resected tumor tissue remains complex and a number of parameters must be respected...

    Giacomo Miserocchi, Laura Mercatali, Chiara Liverani, Alessandro De Vita, Chiara Spadazzi, Federica Pieri, Alberto Bongiovanni, Federica Recine, Dino Amadori and Toni Ibrahim

    Journal of Translational Medicine 2017 15:229

    Published on: 7 November 2017

  9. Research

    Comparison of 68Ga-PSMA-11 PET-CT with mpMRI for preoperative lymph node staging in patients with intermediate to high-risk prostate cancer

    To evaluate the diagnostic value of 68Ga-PSMA-11 PET-CT with multiparametric magnetic resonance imaging (mpMRI) for lymph node (LN) staging in patients with intermediate- to high-risk prostate cancer (PCa) underg...

    Qing Zhang, Shiming Zang, Chengwei Zhang, Yao Fu, Xiaoyu Lv, Qinglei Zhang, Yongming Deng, Chuan Zhang, Rui Luo, Xiaozhi Zhao, Wei Wang, Feng Wang and Hongqian Guo

    Journal of Translational Medicine 2017 15:230

    Published on: 7 November 2017

  10. Research

    Clinicopathological predictors of recurrence in nodular and superficial spreading cutaneous melanoma: a multivariate analysis of 214 cases

    Nodular melanoma (NM) accounts for most thick melanomas and because of their frequent association with ulceration, fast growth rate and high mitotic rate, contribute substantially to melanoma-related mortality...

    Maria A. Pizzichetta, Daniela Massi, Mario Mandalà, Paola Queirolo, Ignazio Stanganelli, Vincenzo De Giorgi, Giovanni Ghigliotti, Stefano Cavicchini, Pietro Quaglino, Maria T. Corradin, Pietro Rubegni, Mauro Alaibac, Stefano Astorino, Fabrizio Ayala, Serena Magi, Laura Mazzoni…

    Journal of Translational Medicine 2017 15:227

    Published on: 7 November 2017

  11. Commentary

    The need for a network to establish and validate predictive biomarkers in cancer immunotherapy

    Immunotherapies have emerged as one of the most promising approaches to treat patients with cancer. Recently, the entire medical oncology field has been revolutionized by the introduction of immune checkpoints...

    Giuseppe V. Masucci, Alessandra Cesano, Alexander Eggermont, Bernard A. Fox, Ena Wang, Francesco M. Marincola, Gennaro Ciliberto, Kevin Dobbin, Igor Puzanov, Janis Taube, Jennifer Wargo, Lisa H. Butterfield, Lisa Villabona, Magdalena Thurin, Michael A. Postow, Paul M. Sondel…

    Journal of Translational Medicine 2017 15:223

    Published on: 3 November 2017

  12. Research

    Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer

    Pigs have many features that make them attractive as biomedical models for various diseases, including cancer. P53 is an important tumor suppressor gene that exerts a central role in protecting cells from onco...

    Youfeng Shen, Kaixiang Xu, Zaimei Yuan, Jianxiong Guo, Heng Zhao, Xuezeng Zhang, Lu Zhao, Yubo Qing, Honghui Li, Weirong Pan, Baoyu Jia, Hong-Ye Zhao and Hong-Jiang Wei

    Journal of Translational Medicine 2017 15:224

    Published on: 3 November 2017

  13. Research

    DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment

    Abnormalities in the tumor microenvironment are associated with resistance to treatment, aggressive growth, and poor clinical outcome in patients with advanced cervical cancer. The potential of dynamic contras...

    Anette Hauge, Catherine S. Wegner, Jon-Vidar Gaustad, Trude G. Simonsen, Lise Mari K. Andersen and Einar K. Rofstad

    Journal of Translational Medicine 2017 15:225

    Published on: 3 November 2017

  14. Research

    Veritable antiviral capacity of natural killer cells in chronic HBV infection: an argument for an earlier anti-virus treatment

    There is limited information on innate immunity, especially natural killer (NK) cell function, in different chronic hepatitis B (CHB) stages. Therefore, we examined whether the clinical staging strategy accura...

    Xiaoyan Li, Liang Zhou, Lin Gu, Yurong Gu, Lubiao Chen, Yifan Lian and Yuehua Huang

    Journal of Translational Medicine 2017 15:220

    Published on: 31 October 2017

  15. Research

    Systemic immune-inflammation index predicting chemoradiation resistance and poor outcome in patients with stage III non-small cell lung cancer

    There is increasing evidence that the existence of systemic inflammation response is correlated with poor prognosis in several solid tumors. The aim of this retrospective study was to investigate the associati...

    Yu-Suo Tong, Juan Tan, Xi-Lei Zhou, Ya-Qi Song and Ying-Jian Song

    Journal of Translational Medicine 2017 15:221

    Published on: 31 October 2017

  16. Review

    GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk

    GlycA is a novel spectroscopic marker of systemic inflammation with low intra-individual variability and other attributes favoring its clinical use in patients with chronic inflammatory and autoimmune diseases...

    Margery A. Connelly, James D. Otvos, Irina Shalaurova, Martin P. Playford and Nehal N. Mehta

    Journal of Translational Medicine 2017 15:219

    Published on: 27 October 2017

  17. Research

    Haemoadsorption reduces the inflammatory response and improves blood flow during ex vivo renal perfusion in an experimental model

    Ex-vivo normothermic perfusion strategies are a promising new instrument in organ transplantation. The perfusion conditions are designed to be protective however the artificial environment can induce a local i...

    Sarah A. Hosgood, Tom Moore, Theresa Kleverlaan, Tom Adams and Michael L. Nicholson

    Journal of Translational Medicine 2017 15:216

    Published on: 25 October 2017

  18. Research

    The effect of renal denervation in an experimental model of chronic renal insufficiency, The REmnant kidney Denervation In Pigs study (REDIP study)

    Renal denervation (RDN) is a promising therapeutic method in cardiology. Its currently most investigated indication is resistant hypertension. Other potential indications are atrial fibrillation, type 2 diabet...

    Jean-Claude Lubanda, Miroslav Chochola, Mikuláš Mlček, Petr Neužil, Josef Marek, Štěpán Havránek, Sylvie Kuchynková, Zdeňka Fingrová, Kao-Hsuan Aimee Huang and Aleš Linhart

    Journal of Translational Medicine 2017 15:215

    Published on: 25 October 2017

  19. Research

    Flow cytometric immunobead assay for quantitative detection of platelet autoantibodies in immune thrombocytopenia patients

    Platelet autoantibody detection is critical for immune thrombocytopenia (ITP) diagnosis and prognosis. Therefore, we aimed to establish a quantitative flow cytometric immunobead assay (FCIA) for ITP platelet a...

    Juping Zhai, Mengyuan Ding, Tianjie Yang, Bin Zuo, Zhen Weng, Yunxiao Zhao, Jun He, Qingyu Wu, Changgeng Ruan and Yang He

    Journal of Translational Medicine 2017 15:214

    Published on: 23 October 2017

  20. Meeting report

    World-Wide Immunoscore Task Force: meeting report from the “Melanoma Bridge”, Napoli, November 30th–December 3rd, 2016

    The predictive accuracy of the traditional staging system is based on disease progression as a tumour cell-autonomous process, but it fails to incorporate the effects of the host immune response. A precise ana...

    Jerome Galon, Alessandro Lugli, Carlo Bifulco, Franck Pages, Giuseppe Masucci, Francesco M. Marincola and Paolo A. Ascierto

    Journal of Translational Medicine 2017 15:212

    Published on: 20 October 2017

  21. Research

    Effect of Infla-Kine supplementation on the gene expression of inflammatory markers in peripheral mononuclear cells and on C-reactive protein in blood

    Chronic inflammation is a predisposing factor to numerous degenerative diseases including cancer, heart failure and Alzheimer’s disease. Infla-Kine is a natural supplement comprised of a proprietary blend of Lact...

    Nina A. Mikirova, Santosh Kesari, Thomas E. Ichim and Neil H. Riordan

    Journal of Translational Medicine 2017 15:213

    Published on: 20 October 2017

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