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  1. Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, emerging as a significant health issue on a global scale. Berberine exhibits potential for treating NAFLD, but clinical e...

    Authors: Qilong Nie, Mingyang Li, Caiyang Huang, Yongwei Yuan, Qiuyan Liang, Xiaojun Ma, Tengyu Qiu and Jianhong Li
    Citation: Journal of Translational Medicine 2024 22:225
  2. In recent years, natural bone extracellular matrix (ECM)-inspired materials have found widespread application as scaffolds for bone tissue engineering. However, the challenge of creating scaffolds that mimic n...

    Authors: Yanqing Yang, Huan He, Fang Miao, Mingwei Yu, Xixi Wu, Yuanhang Liu, Jie Fu, Junwei Chen, Liya Ma, Xiangru Chen, Ximing Peng, Zhen You and Chuchao Zhou
    Citation: Journal of Translational Medicine 2024 22:224
  3. Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor, that is refractory to standard treatment and to immunotherapy with immune-checkpoint inhibitors (ICI). Noteworthy, melanoma brain metas...

    Authors: Maria Fortunata Lofiego, Francesca Piazzini, Francesca Pia Caruso, Francesco Marzani, Laura Solmonese, Emma Bello, Fabrizio Celesti, Maria Claudia Costa, Teresa Noviello, Roberta Mortarini, Andrea Anichini, Michele Ceccarelli, Sandra Coral, Anna Maria Di Giacomo, Michele Maio and Alessia Covre
    Citation: Journal of Translational Medicine 2024 22:223
  4. Colonoscopy is a classic diagnostic method with possible complications including abdominal pain and diarrhoea. In this study, gut microbiota dynamics and related metabolic products during and after colonoscopy...

    Authors: Zhenhui Chen, Lu Yu, Jiaxin Liu, Jingjing Kong, Xiaoshi Deng, Xiaotong Guo, Jiamin Shan, Daixuan Zhou, Wendan Li, Yangfan Lin, Wanwen Huang, Weisen Zeng, Xinlong Shi, Yang Bai and Hongying Fan
    Citation: Journal of Translational Medicine 2024 22:222
  5. Cellular stress associated with static-cold storage (SCS) and warm reperfusion of donor lungs can contribute to ischemia–reperfusion (IR) injury during transplantation. Adding cytoprotective agents to the pres...

    Authors: Dejan Bojic, Tanroop Aujla, Junichi Sugihara, Aaron Wong, Shaf Keshavjee and Mingyao Liu
    Citation: Journal of Translational Medicine 2024 22:221
  6. Targeting CD47/SIRPα axis has emerged as a promising strategy in cancer immunotherapy. Despite the encouraging clinical efficacy observed in hematologic malignancies through CD47-SIRPα blockade, there are safe...

    Authors: Tao Wang, Si-Qin Wang, Yin-Xiao Du, Dan-Dan Sun, Chang Liu, Shuang Liu, Ying-Ying Sun, Hai-Long Wang, Chun-Sheng Zhang, Hai-Long Liu, Lei Jin and Xiao-Ping Chen
    Citation: Journal of Translational Medicine 2024 22:220
  7. The rapid emergence and global dissemination of the Omicron variant of SARS-CoV-2 have posed formidable challenges in public health. This scenario underscores the urgent need for an enhanced understanding of O...

    Authors: Qianyue Yang, Zhiwei Lin, Mingshan Xue, Yueting Jiang, Libing Chen, Jiahong Chen, Yuhong Liao, Jiali Lv, Baojun Guo, Peiyan Zheng, Huimin Huang and Baoqing Sun
    Citation: Journal of Translational Medicine 2024 22:219
  8. Infectious pancreatic necrosis (IPN) is a serious complication of acute pancreatitis, and early recognition and timely intervention are the keys to improving clinical outcomes. The purpose of this study was to...

    Authors: Xiangping Huang, Ling Wu, Qianhui Ouyang, Ying Huang, Lanhui Hong, Sixiang Liu, Kongzhi Yang, Ding Ning and Chao Chao Tan
    Citation: Journal of Translational Medicine 2024 22:218
  9. Lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer, but the early diagnosis rate is low. The RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in several cancers but its mec...

    Authors: Zelai He, Huijun Zhang, Haibo Xiao, Xiangyu Zhang, Hongbo Xu, Ruifen Sun and Siwen Li
    Citation: Journal of Translational Medicine 2024 22:216
  10. Cardiovascular diseases (CVDs) are the leading cause of death around the world. Most CVDs-related death can be prevented by the optimal management of risk factors such as unhealthy diet and physical inactivity...

    Authors: Yun Qian, Jing-Yu (Benjamin) Tan, Tao Wang, Daniel Bressington, Hong-Juan Zhou, Meng-Yuan Li and Xian-Liang Liu
    Citation: Journal of Translational Medicine 2024 22:215
  11. Primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) variant syndrome (VS) exhibit a complex overlap of AIH features with PBC, leading to poorer prognoses than those with PBC or AIH alone. The biom...

    Authors: Fan Yang, Leyu Zhou, Yi Shen, Xianglin Wang, Xiaoli Fan and Li Yang
    Citation: Journal of Translational Medicine 2024 22:214
  12. First identified in Drosophila melanogaster, the Hippo pathway is considered a major regulatory cascade controlling tissue homeostasis and organ development. Hippo signaling components include kinases whose activ...

    Authors: Giulia Schiavoni, Beatrice Messina, Stefano Scalera, Lorenzo Memeo, Cristina Colarossi, Marzia Mare, Giovanni Blandino, Gennaro Ciliberto, Giulia Bon and Marcello Maugeri-Saccà
    Citation: Journal of Translational Medicine 2024 22:213
  13. Clear cell renal cell carcinoma (ccRCC) is known for abnormal lipid metabolism and widespread activation of HIF-2α. Recently, the importance of autophagy in ccRCC has been focused, and it has potential connect...

    Authors: Yu Huang, Zhiyong Xiong, Jianjun Wang, Yafen Gao, Qi Cao, Decai Wang, Jian Shi, Zhixian Chen and Xiong Yang
    Citation: Journal of Translational Medicine 2024 22:212
  14. Lactylation, a novel contributor to post-translational protein modifications, exhibits dysregulation across various tumors. Nevertheless, its intricate involvement in colorectal carcinoma, particularly for non...

    Authors: Huixia Huang, Keji Chen, Yifei Zhu, Zijuan Hu, Yaxian Wang, Jiayu Chen, Yuxue Li, Dawei Li and Ping Wei
    Citation: Journal of Translational Medicine 2024 22:211
  15. Clear cell renal cell carcinoma is a prototypical tumor characterized by metabolic reprogramming, which extends beyond tumor cells to encompass diverse cell types within the tumor microenvironment. Nonetheless...

    Authors: Guanwen Yang, Jiangting Cheng, Jiayi Xu, Chenyang Shen, Xuwei Lu, Chang He, Jiaqi Huang, Minke He, Jie Cheng and Hang Wang
    Citation: Journal of Translational Medicine 2024 22:210
  16. Human discs large-associated protein 5 (DLGAP5) is reported to play a pivotal role in regulating the cell cycle and implicate in tumorigenesis and progression of various cancers. Our current research endeavore...

    Authors: Maojian Chen, Shaoping Zhang, Fan Wang, Junyi He, Wei Jiang and Li Zhang
    Citation: Journal of Translational Medicine 2024 22:209
  17. Mitochondrial alterations, often dependent on unbalanced mitochondrial dynamics, feature in the pathobiology of human cancers, including multiple myeloma (MM). Flavanones are natural flavonoids endowed with mi...

    Authors: Roberta Torcasio, Maria Eugenia Gallo Cantafio, Claudia Veneziano, Carmela De Marco, Ludovica Ganino, Ilenia Valentino, Maria Antonietta Occhiuzzi, Ida Daniela Perrotta, Teresa Mancuso, Filomena Conforti, Bruno Rizzuti, Enrica Antonia Martino, Massimo Gentile, Antonino Neri, Giuseppe Viglietto, Fedora Grande…
    Citation: Journal of Translational Medicine 2024 22:208
  18. The global cellular landscape of the tumor microenvironment (TME) combining primary and metastatic liver tumors has not been comprehensively characterized.

    Authors: Menghui Gui, Shilin Huang, Shizhou Li, Yuying Chen, Furong Cheng, Yulin Liu, Ji-ao Wang, Yuting Wang, Rui Guo, Yiming Lu, Pengbo Cao and Gangqiao Zhou
    Citation: Journal of Translational Medicine 2024 22:206
  19. Flavonoids are a class of secondary plant metabolites that have been shown to have multiple health benefits, including antioxidant and anti-inflammatory. This study was to explore the association between dieta...

    Authors: Runmiao Wu, Xu Zhu, Gongchang Guan, Qianwei Cui, Ling Zhu, Yujie Xing and Jingsha Zhao
    Citation: Journal of Translational Medicine 2024 22:205
  20. Prior evidence demonstrated that Regulator of G protein Signaling 6 (RGS6) translocates to the nucleolus in response to cytotoxic stress though the functional significance of this phenomenon remains unknown.

    Authors: Abhishek Singh Sengar, Manish Kumar, Chetna Rai, Sreemoyee Chakraborti, Dinesh Kumar, Pranesh Kumar, Sukhes Mukherjee, Kausik Mondal, Adele Stewart and Biswanath Maity
    Citation: Journal of Translational Medicine 2024 22:204
  21. Resident memory T (Trm) cells which are specifically located in non-lymphoid tissues showed distinct phenotypes and functions compared to circulating memory T cells and were vital for the initiation of robust ...

    Authors: Jialing Fang, Jun Lei, Boxiao He, Yankang Wu, Peng Chen, Zaiqiao Sun, Ning Wu, Yafei Huang, Pengcheng Wei, Lei Yin and Yongshun Chen
    Citation: Journal of Translational Medicine 2024 22:203
  22. Although the long-term prognosis of papillary thyroid cancer (PTC) is favorable, distant metastasis significantly compromises the prognosis and quality of life for patients with PTC. The Cadherin family plays ...

    Authors: Luyao Wu, Jian Xiao, Dandan Yi, Haoran Ding, Ru Wang, Zehua Duan, Zhijian Liu, Xianbiao Shi, Meiping Shen and Jianfeng Sang
    Citation: Journal of Translational Medicine 2024 22:201
  23. Venous thromboembolism (VTE) is a leading cause of cardiovascular mortality. The diagnosis of acute VTE is based on complex imaging exams due to the lack of biomarkers. Recent multi-omics based research has co...

    Authors: Cláudia Febra, Joana Saraiva, Fátima Vaz, João Macedo, Hamza Mohammad Al-Hroub, Mohammad Harb Semreen, Rui Maio, Vitor Gil, Nelson Soares and Deborah Penque
    Citation: Journal of Translational Medicine 2024 22:200
  24. Heart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of heart failure cases. The molecular mechanisms by which HFpEF leads to impaired diastolic function of the heart have not ...

    Authors: Yixiao Xiong, Xin Liu, Ling Jiang, Tao Hao, Yanyan Wang and Tao Li
    Citation: Journal of Translational Medicine 2024 22:199
  25. Angiogenesis inhibitors have been identified to improve the efficacy of immunotherapy in recent studies. However, the delayed therapeutic effect of immunotherapy poses challenges in treatment planning. Therefo...

    Authors: Xi Xu, Mengjie Ma, Kunlin Ye, Dong Zhang, Xinhui Chen, Jiayang Wu, Xukai Mo, Zeyu Xiao, Changzheng Shi and Liangping Luo
    Citation: Journal of Translational Medicine 2024 22:198
  26. Metabolic and bariatric surgery (MBS) is safe and efficacious in treating adolescents with severe obesity. Behavioral/lifestyle programs can support successful preparation for surgery and post-MBS weight loss,...

    Authors: Maral Misserian, Alicia Wheelington, Rashon King, Jackson Francis, M. Sunil Mathew, Marlyn A. Allicock, Bethany R. Cartwright, Adejumoke Adewunmi, Aparajita Chandrasekhar, Dhatri Polavarapu, Faisal G. Qureshi, Sarah E. Barlow and Sarah E. Messiah
    Citation: Journal of Translational Medicine 2024 22:197
  27. Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose global prevalence is rapidly increasing. Acetyl CoA carboxylases 1 (ACACA) is the key enzyme that controls the rate of fatt...

    Authors: Jian Dong, Muzi Li, Runsheng Peng, Yuchuan Zhang, Zilin Qiao and Na Sun
    Citation: Journal of Translational Medicine 2024 22:196
  28. Immunotherapy has significantly improved survival of esophageal squamous cell cancer (ESCC) patients, however the clinical benefit was limited to only a small portion of patients. This study aimed to perform a...

    Authors: Butuo Li, Wenru Qin, Linlin Yang, Haoqian Li, Chao Jiang, Yueyuan Yao, Shuping Cheng, Bing Zou, Bingjie Fan, Taotao Dong and Linlin Wang
    Citation: Journal of Translational Medicine 2024 22:195
  29. Peripheral nerve injury (PNI) is commonly observed in clinical practice, yet the underlying mechanisms remain unclear. This study investigated the correlation between the expression of a Ras-related protein Ra...

    Authors: Jiayi Wang, Pin Chen, Guanjie Han, Yongjie Zhou, Xingdong Xiang, Mengxuan Bian, Lei Huang, Xiang Wang, Binfeng He and Shunyi Lu
    Citation: Journal of Translational Medicine 2024 22:194
  30. Aberrant upregulation of the ubiquitin-specific protease 14 (USP14) has been found in some malignant tumors, including oral squamous cell carcinoma (OSCC). In this study, we further demonstrated that aberrantl...

    Authors: Xingming Zhang, Lou Geng, Yi Tang, Yingying Wang, Youping Zhang, Chujiao Zhu, Hu Lei, Hanzhang Xu, Qi Zhu, Yingli Wu and Wenli Gu
    Citation: Journal of Translational Medicine 2024 22:193
  31. Zinc finger SWIM-type containing 4 (ZSWIM4) induces drug resistance in breast cancer cells. However, its role in epithelial ovarian cancer (EOC) remains unknown. In this study, we aimed to investigate the clin...

    Authors: Kunxiang Gong, Yinger Huang, Yanqin Zheng, Wenbo Hao and Kun Shi
    Citation: Journal of Translational Medicine 2024 22:192
  32. In the Netherlands, the prevalence of post COVID-19 condition is estimated at 12.7% at 90–150 days after SARS-CoV-2 infection. This study aimed to determine the occurrence of fatigue and other symptoms, to ass...

    Authors: Merel E. B. Cornelissen, Lizan D. Bloemsma, Anouk W. Vaes, Nadia Baalbaki, Qichen Deng, Rosanne J. H. C. G. Beijers, Lieke C. E. Noij, Laura Houweling, Somayeh Bazdar, Martijn A. Spruit and Anke H. Maitland-van der Zee
    Citation: Journal of Translational Medicine 2024 22:191
  33. Predictive biomarkers of immune checkpoint inhibitor (ICI) efficacy are currently lacking for non-small cell lung cancer (NSCLC). Here, we describe the results from the Anti–PD-1 Response Prediction DREAM Chal...

    Authors: Mike Mason, Óscar Lapuente-Santana, Anni S. Halkola, Wenyu Wang, Raghvendra Mall, Xu Xiao, Jacob Kaufman, Jingxin Fu, Jacob Pfeil, Jineta Banerjee, Verena Chung, Han Chang, Scott D. Chasalow, Hung Ying Lin, Rongrong Chai, Thomas Yu…
    Citation: Journal of Translational Medicine 2024 22:190
  34. Combined small-cell lung carcinoma (cSCLC) represents a rare subtype of SCLC, the mechanisms governing the evolution of cancer genomes and their impact on the tumor immune microenvironment (TIME) within distin...

    Authors: Wenjuan Ma, Ting Zhou, Mengmeng Song, Jiaqing Liu, Gang Chen, Jianhua Zhan, Liyan Ji, Fan Luo, Xuan Gao, Pansong Li, Xuefeng Xia, Yan Huang and Li Zhang
    Citation: Journal of Translational Medicine 2024 22:189
  35. Diagnosis of colorectal cancer (CRC) during early stages can greatly improve patient outcome. Although technical advances in the field of genomics and proteomics have identified a number of candidate biomarker...

    Authors: Hanju Hua, Tingting Wang, Liangxuan Pan, Xiaoyao Du, Tianxue Xia, Zhenzhong Fa, Lei Gu, Fei Gao, Chaohui Yu, Feng Gao, Lujian Liao and Zhe Shen
    Citation: Journal of Translational Medicine 2024 22:188
  36. The initial idea of functional tissue replacement has shifted to the concept that injected cells positively modulate myocardial healing by a non-specific immune response of the transplanted cells within the ta...

    Authors: Moritz Schweins, Ralf Gäbel, Matti Raitza, Praveen Vasudevan, Heiko Lemcke, Markus Joksch, Anna Schildt, Jens Kurth, Tobias Lindner, Felix G. Meinel, Alper Öner, Hüseyin Ince, Brigitte Vollmar, Bernd Joachim Krause, Robert David and Cajetan Immanuel Lang
    Citation: Journal of Translational Medicine 2024 22:187
  37. Kidney transplantation stands out as the most effective renal replacement therapy for patients grappling with end-stage renal disease. However, post-transplant renal fibrosis is a prevalent and irreversible co...

    Authors: Xinhao Niu, Cuidi Xu, Yin Celeste Cheuk, Xiaoqing Xu, Lifei Liang, Pingbao Zhang and Ruiming Rong
    Citation: Journal of Translational Medicine 2024 22:186
  38. Clinical data mining of predictive models offers significant advantages for re-evaluating and leveraging large amounts of complex clinical real-world data and experimental comparison data for tasks such as ris...

    Authors: Huimin Qiao, Yijing Chen, Changshun Qian and You Guo
    Citation: Journal of Translational Medicine 2024 22:185
  39. We previously showed that the nab-paclitaxel plus S-1 (NPS) regimen had promising effects against metastatic pancreatic ducal adenocarcinoma (mPDAC), whose efficacy however could not be precisely predicted by ...

    Authors: Lei Huang, Yao Lv, Shasha Guan, Huan Yan, Lu Han, Zhikuan Wang, Quanli Han, Guanghai Dai and Yan Shi
    Citation: Journal of Translational Medicine 2024 22:184
  40. Myasthenia gravis (MG) and the experimental autoimmune MG (EAMG) animal model are characterized by T-cell-induced and B-cell-dominated autoimmune diseases that affect the neuromuscular junction. Several subtyp...

    Authors: Yong Peng, Huan Yang, Quan Chen, Hong Jin, Ya-hui Xue, Miao-qiao Du, Shu Liu and Shun-yu Yao
    Citation: Journal of Translational Medicine 2024 22:183
  41. Digital histopathology provides valuable information for clinical decision-making. We hypothesized that a deep risk network (DeepRisk) based on digital pathology signature (DPS) derived from whole-slide images...

    Authors: Mengxin Tian, Zhao Yao, Yufu Zhou, Qiangjun Gan, Leihao Wang, Hongwei Lu, Siyuan Wang, Peng Zhou, Zhiqiang Dai, Sijia Zhang, Yihong Sun, Zhaoqing Tang, Jinhua Yu and Xuefei Wang
    Citation: Journal of Translational Medicine 2024 22:182
  42. The clinical application of cell therapies is becoming increasingly important for the treatment of cancer, congenital immune deficiencies, and hemoglobinopathies. These therapies have been primarily manufactur...

    Authors: David F. Stroncek, Nan Zhang, Jiaqiang Ren, Rob Somerville and Anh Dinh
    Citation: Journal of Translational Medicine 2024 22:181
  43. The morbidity of gestational diabetes mellitus (GDM) is increasing and is associated with adverse perinatal outcomes and long-term maternal and infant health. The exact mechanism underlying changes in plasma f...

    Authors: Haoyi Du, Danyang Li, Laura Monjowa Molive and Na Wu
    Citation: Journal of Translational Medicine 2024 22:180
  44. Acute pancreatitis and non-alcoholic fatty liver disease are both serious diseases in the digestive system. The pathogenesis of both diseases is extremely complex closely and it related to gut microbiota, infl...

    Authors: Congzhi Yan, Jingxia Bao and Jinji Jin
    Citation: Journal of Translational Medicine 2024 22:179
  45. Overexpression of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is related to the exhaustion of CD8+ tumor-infiltrating lymphocytes (TILs) in diffuse large B-cell lymphoma (DLBCL). However, t...

    Authors: Qiqi Zhu, Yiming Yang, Kexin Chen, Qiaoyu Zhang, Yifan Huang and Shunhai Jian
    Citation: Journal of Translational Medicine 2024 22:174
  46. Lung cancer, a prevalent and aggressive disease, is characterized by recurrence and drug resistance. It is essential to comprehend the fundamental processes and discover novel therapeutic objectives for augmen...

    Authors: Ailing Wang, Wei-sha Zheng, Zhen Luo, Lian Bai and Shi Zhang
    Citation: Journal of Translational Medicine 2024 22:173
  47. Hepatocellular carcinoma (HCC) is characterized by aggressive progression and elevated mortality rates. This study aimed to investigate the regulatory effects of RBBP7 on HCC pathogenesis and the underlying me...

    Authors: Yuan Fang, WeiQiang Tang, Siming Qu, ZhiTao Li, XiaoLi Zhang, YingLei Miao, Zhong Zeng and HanFei Huang
    Citation: Journal of Translational Medicine 2024 22:170

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