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  1. Biologic TNF-α inhibitors (bTNFIs) can block cerebral TNF-α in Alzheimer’s disease (AD) if these macromolecules can cross the blood–brain barrier (BBB). Thus, a model bTNFI, the extracellular domain of type II...

    Authors: Nataraj Jagadeesan, G. Chuli Roules, Devaraj V. Chandrashekar, Joshua Yang, Sanjana Kolluru and Rachita K. Sumbria
    Citation: Journal of Translational Medicine 2024 22:291
  2. Lipid metabolism is widely reprogrammed in tumor cells. Lipid droplet is a common organelle existing in most mammal cells, and its complex and dynamic functions in maintaining redox and metabolic balance, regu...

    Authors: Boer Deng, Weimin Kong, Xiaochang Shen, Chao Han, Ziyi Zhao, Shuning Chen, Chunxiao Zhou and Victoria Bae-Jump
    Citation: Journal of Translational Medicine 2024 22:290
  3. Global myopia prevalence poses a substantial public health burden with vision-threatening complications, necessitating effective prevention and control strategies. Precise prediction of spherical equivalent (S...

    Authors: Jing Zhao, Yanze Yu, Yiming Li, Feng Li, Zhe Zhang, Weijun Jian, Zhi Chen, Yang Shen, Xiaoying Wang, Zhengqiang Ye, Chencui Huang and Xingtao Zhou
    Citation: Journal of Translational Medicine 2024 22:289
  4. Non-small cell lung cancer (NSCLC) often exhibits resistance to radiotherapy, posing significant treatment challenges. This study investigates the role of SMAD3 in NSCLC, focusing on its potential in influenci...

    Authors: Fushi Han, Shuzhen Chen, Kangwei Zhang, Kunming Zhang, Meng Wang and Peijun Wang
    Citation: Journal of Translational Medicine 2024 22:288
  5. Protein cysteine oxidation is substantially involved in various biological and pathogenic processes, but its implications in pancreatic cancer development remains poorly understood.

    Authors: Chaochao Tan, Lichun Chen, Xiaoyu Guan, Wenyi Huang, Yinhong Feng, Ziyi Li, Ling Wu, Xiangping Huang, Qianhui Ouyang, Sixiang Liu, Ying Huang and Jiliang Hu
    Citation: Journal of Translational Medicine 2024 22:287
  6. Osteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of the joint. As the disease progresses, patients will gradually develop symptoms such as pain, physical limitations and even...

    Authors: Chunran Pan, Fan Lu, Xiaoxia Hao, Xiaofeng Deng, Jiawei Liu, Kai Sun, Wenjie Hou, Xingru Shang, Ruimin Chi, Fengjing Guo and Tao Xu
    Citation: Journal of Translational Medicine 2024 22:286
  7. Lactate is traditionally recognized as a by-product of anaerobic metabolism. However, lactate is a preferred oxidative substrate for stressed myocardium. Exogenous lactate infusion increases cardiac output (CO...

    Authors: Oskar Kjærgaard Hørsdal, Niels Moeslund, Kristoffer Berg-Hansen, Roni Nielsen, Niels Møller, Hans Eiskjær, Henrik Wiggers and Nigopan Gopalasingam
    Citation: Journal of Translational Medicine 2024 22:285
  8. Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition characterized by severe gut inflammation, commonly presenting as Crohn’s disease, ulcerative colitis or categorized as IBD- unclassified...

    Authors: Manoj Kumar, Selvasankar Murugesan, Nazira Ibrahim, Mamoun Elawad and Souhaila Al Khodor
    Citation: Journal of Translational Medicine 2024 22:284
  9. The activation of glycolysis, particularly in the context of reprogrammed energy metabolism, is increasingly recognized as a significant characteristic of cancer. However, the precise mechanisms by which glyco...

    Authors: Wei Zhou, Mengyuan Tang, Dan He, Yi Shen, Ziwei Huang, Wenxin Xia, Zhiyun Wu, Wenxiang Wei, Hui Zheng, Qi Wang, Weifeng Shi and Jingting Jiang
    Citation: Journal of Translational Medicine 2024 22:283
  10. Oral inflammatory diseases are localized infectious diseases primarily caused by oral pathogens with the potential for serious systemic complications. However, publicly available datasets for these diseases ar...

    Authors: Weiyin Lin, Hong Yang, Jiayu Lin, Xia Yang, Zhihao Liao, Yifan Zheng, Peng Luo and Chufeng Liu
    Citation: Journal of Translational Medicine 2024 22:282
  11. Osteoarthritis (OA) is a multifactorial, hypertrophic, and degenerative condition involving the whole joint and affecting a high percentage of middle-aged people. It is due to a combination of factors, althoug...

    Authors: Maria Claudia Costa, Claudia Angelini, Monica Franzese, Concetta Iside, Marco Salvatore, Luigi Laezza, Francesco Napolitano and Michele Ceccarelli
    Citation: Journal of Translational Medicine 2024 22:281
  12. Ovarian cancer (OC) is distinguished by its aggressive nature and the limited efficacy of current treatment strategies. Recent studies have emphasized the significant role of cancer-associated fibroblasts (CAF...

    Authors: Songwei Feng, Bo Ding, Zhu Dai, Han Yin, Yue Ding, Sicong Liu, Ke Zhang, Hao Lin, Zhongdang Xiao and Yang Shen
    Citation: Journal of Translational Medicine 2024 22:280
  13. LILRB3, a member of the leukocyte immunoglobulin-like receptor B (LILRB) family, has immunosuppressive functions and directly regulates cancer development, which indicates that LILRB3 is an attractive target f...

    Authors: Qingyan Cen, Jianyu Chen, Jiaxin Guo, Mu Chen, Hao Wang, Suwan Wu, Honghao Zhang, Xiaoling Xie and Yuhua Li
    Citation: Journal of Translational Medicine 2024 22:278
  14. Authors: Kai Horny, Christoph Sproll, Lukas Peiffer, Frauke Furtmann, Patricia Gerhardt, Jan Gravemeyer, Nikolas H. Stoecklein, Ivelina Spassova and Jürgen C. Becker
    Citation: Journal of Translational Medicine 2024 22:277

    The original article was published in Journal of Translational Medicine 2023 21:267

  15. CLAD (Chronic Lung Allograft Dysfunction) remains a serious complication following lung transplantation. Some evidence shows that portions of Extracorporeal Photopheresis (ECP)-treated patients improve/stabili...

    Authors: Sara Bozzini, Eleonora Bozza, Cecilia Bagnera, Claudia Del Fante, Eugenio Barone, Simona De Vitis, Mara De Amici, Giorgia Testa, Stefania Croce, Chiara Valsecchi, Maria A Avanzini, Rosalia Cacciatore, Cristina Mortellaro, Gianluca Viarengo, Cesare Perotti and Federica Meloni
    Citation: Journal of Translational Medicine 2024 22:276
  16. The prognostic significance of myelofibrosis (MF) grade in patients with myelodysplastic syndrome (MDS) following an allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains elusive.

    Authors: Panpan Zhu, Xiaoyu Lai, Lizhen Liu, Jimin Shi, Jian Yu, Yanmin Zhao, Luxin Yang, Tingting Yang, Weiyan Zheng, Jie Sun, Wenjun Wu, Yi Zhao, Zhen Cai, He Huang and Yi Luo
    Citation: Journal of Translational Medicine 2024 22:275
  17. Chimeric antigen receptor natural killer (CAR-NK) cells represent a promising advancement in CAR cell therapy, addressing limitations observed in CAR-T cell therapy. However, our prior study revealed challenge...

    Authors: Na Yang, Caili Zhang, Yingchun Zhang, Yuting Fan, Jing Zhang, Xiaojin Lin, Ting Guo, Yangzuo Gu, Jieheng Wu, Jianmei Gao, Xing Zhao and Zhixu He
    Citation: Journal of Translational Medicine 2024 22:274
  18. Chimeric antigen receptor (CAR) T cell therapy is associated with high risk of adverse events. Glucocorticoids (GCs) are cornerstone in the management of high-grade cytokine release syndrome (CRS) and immune e...

    Authors: Thomas Poiret, Sara Vikberg, Esther Schoutrop, Jonas Mattsson and Isabelle Magalhaes
    Citation: Journal of Translational Medicine 2024 22:273
  19. In HBV-associated HCC, T cells often exhibit a state of functional exhaustion, which prevents the immune response from rejecting the tumor and allows HCC to progress. Moreover, polymerase-specific T cells exhi...

    Authors: Yan Jia, Jianing Zhao, Chunqing Wang, Jing Meng, Liqing Zhao, Hongwei Yang and Xiaoqing Zhao
    Citation: Journal of Translational Medicine 2024 22:272
  20. Patients with spondyloarthritis (SpA)/HLA-B27-associated acute anterior uveitis (AAU) experience recurring acute flares, which pose significant visual and financial challenges. Despite established links betwee...

    Authors: Shuming Chen, Weidi Huang, Qiaoqian Wan, Zichun Tang, Xie Li, Fang Zeng, Shuyan Zheng, Zhuo Li and Xiao Liu
    Citation: Journal of Translational Medicine 2024 22:271
  21. Most anti-cancer modalities are designed to directly kill cancer cells deploying mechanisms of action (MOAs) centered on the presence of a precise target on cancer cells. The efficacy of these approaches is li...

    Authors: Joyce Hu, Paolo Ascierto, Alessandra Cesano, Volker Herrmann and Francesco M. Marincola
    Citation: Journal of Translational Medicine 2024 22:270
  22. Chemotherapy is a primary treatment for cancer, but its efficacy is often limited by cancer-associated bacteria (CAB) that impair tumor suppressor functions. Our previous research found that Mycoplasma fermentans

    Authors: Francesca Benedetti, Emmanuel F. Mongodin, Jonathan H. Badger, Arshi Munawwar, Ashley Cellini, Weirong Yuan, Giovannino Silvestri, Carl N. Kraus, Simone Marini, Chozha V. Rathinam, Marco Salemi, Hervé Tettelin, Robert C. Gallo and Davide Zella
    Citation: Journal of Translational Medicine 2024 22:269
  23. MicroRNAs (miRNAs) play a crucial role in gene expression and regulation, with dysregulation of miRNA function linked to various diseases, including hepatitis C virus (HCV)-related hepatocellular carcinoma (HC...

    Authors: Ciniso Sylvester Shabangu, Wen-Hsiu Su, Chia-Yang Li, Ming-Lung Yu, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang and Shu-Chi Wang
    Citation: Journal of Translational Medicine 2024 22:268
  24. Mitophagy, a prominent cellular homeostasis process, has been implicated in modulating endothelial cell function. Emerging evidence suggests that extracellular vesicles (EVs) participate in intercellular commu...

    Authors: Xiang Ying, Xiaocui Zheng, Xiaoqian Zhang, Yujia Yin and Xipeng Wang
    Citation: Journal of Translational Medicine 2024 22:267
  25. The clinical routine test of HBV-specific T cell reactivity is still limited due to the high polymorphisms of human leukocyte antigens (HLA) in patient cohort and the lack of universal detection kit, thus the ...

    Authors: Yandan Wu, Xiaotao Liu, Yuan Mao, Ruixue Ji, Lingzhi Xia, Zining Zhou, Yan Ding, Pinqing Li, Yu Zhao, Min Peng, Jie Qiu and Chuanlai Shen
    Citation: Journal of Translational Medicine 2024 22:266
  26. Identifying individuals with mild cognitive impairment (MCI) at risk of progressing to Alzheimer’s disease (AD) provides a unique opportunity for early interventions. Therefore, accurate and long-term predicti...

    Authors: Yifan Wang, Ruitian Gao, Ting Wei, Luke Johnston, Xin Yuan, Yue Zhang and Zhangsheng Yu
    Citation: Journal of Translational Medicine 2024 22:265
  27. Idiopathic Pulmonary Fibrosis (IPF) is a type of chronic interstitial pneumonia, often fatal, with elusive causes and a bleak prognosis. Its treatment options are limited and largely ineffective. Early detecti...

    Authors: Wenhua Gan, Wenwen Song, Yujuan Gao, Xuexue Zheng, Fengjuan Wang, Zirui Zhang, Ke Zen, Hongwei Liang and Xin Yan
    Citation: Journal of Translational Medicine 2024 22:264
  28. Angiopoietin-like protein 3 (ANGPTL3) is secreted by hepatocytes and inhibits lipoprotein lipase and endothelial lipase activity. Previous studies reported the correlation between plasma ANGPTL3 levels and hig...

    Authors: Longyan Yang, Yan Wang, Yongsong Xu, Kun Li, Ruili Yin, Lijie Zhang, Di Wang, Lingling Wei, Jianan Lang, Yanan Cheng, Lu Wang, Jing Ke and Dong Zhao
    Citation: Journal of Translational Medicine 2024 22:263
  29. The mitochondria and endoplasmic reticulum (ER) communicate via contact sites known as mitochondria associated membranes (MAMs). Many important cellular functions such as bioenergetics, mitophagy, apoptosis, a...

    Authors: Yi Li, Hua-bin Wang, Jin-long Cao, Wen-jun Zhang, Hai-long Wang, Chang-hong Xu, Kun-peng Li, Yi Liu, Ji-rong Wang, Hua-lan Ha, Sheng-jun Fu and Li Yang
    Citation: Journal of Translational Medicine 2024 22:261
  30. Amino acids (AAs) are one of the primary metabolic substrates for cardiac work. The correlation between AAs and both atrial fibrillation (AF) and aging has been documented. However, the relationship between AA...

    Authors: Yunying Huang, Qiuzhen Lin, Yong Zhou, Jiayi Zhu, Yingxu Ma, Keke Wu, Zuodong Ning, Zixi Zhang, Na Liu, Mohan Li, Yaozhong Liu, Tao Tu and Qiming Liu
    Citation: Journal of Translational Medicine 2024 22:259
  31. The term eGene has been applied to define a gene whose expression level is affected by at least one independent expression quantitative trait locus (eQTL). It is both theoretically and empirically important to...

    Authors: Shuo Zhang, Zhou Jiang and Ping Zeng
    Citation: Journal of Translational Medicine 2024 22:258
  32. Neural Tube Defects (NTDs) are congenital malformations of the central nervous system resulting from the incomplete closure of the neural tube during early embryonic development. Neuroinflammation refers to th...

    Authors: Wenshuang Wang, Yanhong Ji, Zhexu Dong, Zheran Liu, Shuang Chen, Lei Dai, Xiaolan Su, Qingyuan Jiang and Hongxin Deng
    Citation: Journal of Translational Medicine 2024 22:257
  33. Children with cancer receiving chemotherapy commonly report a cluster of psychoneurological symptoms (PNS), including pain, fatigue, anxiety, depression, and cognitive dysfunction. The role of the gut microbio...

    Authors: Jinbing Bai, Ronald Eldridge, Madelyn Houser, Melissa Martin, Christie Powell, Kathryn S. Sutton, Hye In Noh, Yuhua Wu, Thomas Olson, Konstantinos T. Konstantinidis and Deborah W. Bruner
    Citation: Journal of Translational Medicine 2024 22:256
  34. Benign prostatic hyperplasia (BPH) is common in elder men. The current study aims to identify differentially expressed genes (DEGs) in hyperplastic prostate and to explore the role of Nik related kinase (NRK) ...

    Authors: Weixiang He, Zelin Tian, Bingchen Dong, Yitong Cao, Wei Hu, Peng Wu, Lei Yu, Xinhua Zhang and Shanshan Guo
    Citation: Journal of Translational Medicine 2024 22:255
  35. Although hepatitis B virus (HBV) infection is a major risk factor for hepatic cancer, the majority of HBV carriers do not develop this lethal disease. Additional molecular alterations are thus implicated in th...

    Authors: Fuqiang Huang, Jing Guo, Na Zhao, Mengjie Hou, Xiaochen Gai, Shuhui Yang, Pei Cai, Yanan Wang, Qian Ma, Qi Zhao, Li Li, Huayu Yang, Yanling Jing, Di Jin, Zhongdong Hu, Xiaojun Zha…
    Citation: Journal of Translational Medicine 2024 22:254
  36. Tobacco pollutants are prevalent in the environment, leading to inadvertent exposure of pregnant females. Studies of these pollutants' toxic effects on embryonic development have not fully elucidated the poten...

    Authors: Jiasheng Chen, Yuxin Lin, Deyi Gen, Wanxian Chen, Rui Han, Hao Li, Shijie Tang, Shukai Zheng and Xiaoping Zhong
    Citation: Journal of Translational Medicine 2024 22:253
  37. Albuminuria, the presence of excess of protein in urine, is a well-known risk factor for early kidney damage among diabetic/prediabetic patients. There is a complex interaction between physical activity (PA) a...

    Authors: Bingquan Xiong, Yufan Wang, Juan He, Lisha Wang, Rui He, Min Zhu, Jiaxing Wang, Yingrui Li, Bin Liu, Kaihu Xiao and Qiang She
    Citation: Journal of Translational Medicine 2024 22:252
  38. Circular RNAs (circRNAs) have been proved to play crucial roles in the development of various cancers. However, the molecular mechanism of circGLIS3 involved in gastric cancer (GC) tumorigenesis has not been e...

    Authors: Yongxin Zhang, Xiaofeng Wang, Wenwei Liu, Tianxiang Lei, Tang Qiao, Wei Feng and Wu Song
    Citation: Journal of Translational Medicine 2024 22:251
  39. Intratumoral injection of oncolytic viruses (OVs) shows promise in immunotherapy: ONCOS-102, a genetically engineered OV that encodes Granulocyte–Macrophage Colony-Stimulating Factor (GM-CSF) demonstrated effi...

    Authors: Neshat Saffarzadeh, Emelie Foord, Eoghan O’Leary, Rand Mahmoun, Thomas Birkballe Hansen, Victor Levitsky, Thomas Poiret and Michael Uhlin
    Citation: Journal of Translational Medicine 2024 22:250
  40. Bioactive lipids involved in the progression of various diseases. Nevertheless, there is still a lack of biomarkers and relative regulatory targets. The lipidomic analysis of the samples from platinum-resistan...

    Authors: Menglin Chen, Cancan Zhang, Huaizhi Li, Shanshan Zheng, Yaqi Li, Mengyun Yuan, Yuxuan Chen, Jian Wu and Qingmin Sun
    Citation: Journal of Translational Medicine 2024 22:249
  41. Acute ischemic stroke is a common neurological disease with a significant financial burden but lacks effective drugs. Hypoxia-inducible factor (HIF) and prolyl hydroxylases (PHDs) participate in the pathophysi...

    Authors: Jian Xie, Yuan Zhang, Bin Li, Wen Xi, Yu Wang, Lu Li, Chenchen Liu, Ling Shen, Bing Han, Yan Kong, HongHong Yao and Zhijun Zhang
    Citation: Journal of Translational Medicine 2024 22:248
  42. Currently, noninvasive imaging techniques and circulating biomarkers are still insufficient to accurately assess carotid plaque stability, and an in-depth understanding of the molecular mechanisms that contrib...

    Authors: Zhichao Lai, Chaonan Wang, Xiaoyan Liu, Haidan Sun, Zhengguang Guo, Jiang Shao, Kang Li, Junye Chen, Jiaxian Wang, Xiangling Lei, Keqiang Shu, Yuyao Feng, Deqiang Kong, Wei Sun and Bao Liu
    Citation: Journal of Translational Medicine 2024 22:247
  43. Thrombo-inflammation and neutrophil extracellular traps (NETs) are exacerbated in severe cases of COVID-19, potentially contributing to disease exacerbation. However, the mechanisms underpinning this dysregula...

    Authors: Geoffrey Garcia, Sylvie Labrouche-Colomer, Alexandre Duvignaud, Etienne Clequin, Charles Dussiau, David-Alexandre Trégouët, Denis Malvy, Renaud Prevel, Atika Zouine, Isabelle Pellegrin, Julien Goret, Maria Mamani-Matsuda, Antoine Dewitte and Chloe James
    Citation: Journal of Translational Medicine 2024 22:246
  44. In diabetic retinopathy (DR), hypoxia-inducible factor (HIF-1α) induces oxidative stress by upregulating glycolysis. This process leads to neurodegeneration, particularly photoreceptor cell damage, which furth...

    Authors: Bolin Chen, Jing Zou, Lihui Xie, Yinjun Cai, Bowen Li, Wei Tan, Jinhaohao Huang, Fangling Li and Huizhuo Xu
    Citation: Journal of Translational Medicine 2024 22:245
  45. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for hematological malignancies. However, viral infections, particularly EBV infection, frequently occur following allo-H...

    Authors: Xun-Hong Cao, Ze-Ying Fan, Ying-Jun Chang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang and Xiang-Yu Zhao
    Citation: Journal of Translational Medicine 2024 22:244
  46. Tumor regression following immune checkpoint blockade (ICB) is often associated with immune-related adverse events (irAEs), marked by inflammation in non-cancerous tissues. This study was undertaken to investi...

    Authors: Shuming Chen, Tracee L. McMiller, Abha Soni, Farah Succaria, John-William Sidhom, Laura C. Cappelli, Livia A. Casciola-Rosen, Isaac R. Morales, Preethi Sankaran, Alan E. Berger, Julie Stein Deutsch, Qingfeng C. Zhu, Robert A. Anders, Jody E. Hooper, Drew M. Pardoll, Evan J. Lipson…
    Citation: Journal of Translational Medicine 2024 22:241
  47. Mitochondria produce adenosine triphosphate through respiratory activities to power sperm differentiation and motility, and decreased mitochondrial respiratory activity can result in poor sperm motility and as...

    Authors: Yining Liu, Tongtong Li, Mingze Shi, Yanling Wan, Hanzhen Li, Mingyu Zhang, Ziqi Wang, Shiyu Wang, Yue Lv, Gang Lu, Hongbin Liu, Haobo Zhang and Tao Huang
    Citation: Journal of Translational Medicine 2024 22:240

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