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  1. Aberrant epigenetic changes, like DNA methylation, histone modifications, or ubiquitination, could trigger metabolic disorders in human cancer cells. This study planed to uncover the biological roles of epigen...

    Authors: Wei Yan, Xue Shi, Huihan Wang, Aijun Liao and Wei Yang
    Citation: Journal of Translational Medicine 2022 20:296
  2. There is no approved pharmaceutical intervention for Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS). Fatigue in these patients can last for decades. Long COVID may continue to ME/CFS, and current...

    Authors: Alan Cash and David Lyons Kaufman
    Citation: Journal of Translational Medicine 2022 20:295
  3. Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and has become a huge public health issue worldwide. Inhibition of nucleotide oligomerization domain-like receptors con...

    Authors: Chao Wu, Yanqin Bian, Bingjie Lu, Dan Wang, Nisma Lena Bahaji Azami, Gang Wei, Feng Ma and Mingyu Sun
    Citation: Journal of Translational Medicine 2022 20:294
  4. The current study aimed to construct a novel cancer artificial intelligence survival analysis system for predicting the individual mortality risk curves for cervical carcinoma patients receiving different trea...

    Authors: Jieyi Liang, Tingshan He, Hong Li, Xueqing Guo and Zhiqiao Zhang
    Citation: Journal of Translational Medicine 2022 20:293
  5. Triple negative breast cancer (TNBC) is an aggressive disease characterized by high risk of relapse and development of resistance to different chemotherapy agents. Several targeted therapies have been investig...

    Authors: Stefania Cocco, Alessandra Leone, Maria Serena Roca, Rita Lombardi, Michela Piezzo, Roberta Caputo, Chiara Ciardiello, Susan Costantini, Francesca Bruzzese, Maria José Sisalli, Alfredo Budillon and Michelino De Laurentiis
    Citation: Journal of Translational Medicine 2022 20:290
  6. Ulcerative colitis (UC) is a heterogeneous disorder with complex pathogenesis. Therefore, in the present study, we aimed to assess genome-wide DNA methylation changes associated explicitly with the pathogenesi...

    Authors: Hao-ming Xu, Jing Xu, Mei-feng Yang, Yu-jie Liang, Quan-zhou Peng, Yuan Zhang, Cheng-mei Tian, Yu-qiang Nie, Li-sheng Wang, Jun Yao and De-feng Li
    Citation: Journal of Translational Medicine 2022 20:289
  7. Chemoresistance serves as a huge obstacle for acute myeloid leukemia (AML) patients. To counteract the chemoresistance in AML cells, we discussed the role of maternally expressed gene 3 (MEG3) in arabinocytosi...

    Authors: Airong Wang, Yufei Chen, Luyao Shi, Mengya Li, Lingling Li, Shujuan Wang and Chong Wang
    Citation: Journal of Translational Medicine 2022 20:288
  8. Colorectal cancer (CRC) is a common malignant tumor with a high risk of metastasis. Long non-coding RNAs (lncRNAs) have been reported to be implicated in cancer progression via regulating its nearby gene. Here...

    Authors: Yuliang Pan, Yuxing Zhu, Jun Zhang, Long Jin and Peiguo Cao
    Citation: Journal of Translational Medicine 2022 20:287
  9. Malignant mesothelioma (MM) is a rare orphan aggressive neoplasia with low survival rates. Among the other signaling pathways, ErbB receptors and Hh signaling are deregulated in MM. Thus, molecules involved in...

    Authors: Roberto Bei, Monica Benvenuto, Chiara Focaccetti, Sara Fazi, Marta Moretti, Daniela Nardozi, Valentina Angiolini, Sara Ciuffa, Loredana Cifaldi, Raffaele Carrano, Camilla Palumbo, Martino Tony Miele, Riccardo Bei, Giovanni Barillari, Vittorio Manzari, Enrico De Smaele…
    Citation: Journal of Translational Medicine 2022 20:286
  10. Aberrant glycosylation has been recognized as a hallmark of cancer and N-glycosylation is one of the main types of glycosylation in eukaryotes. Although N-glycoproteomics has made contributions to the discover...

    Authors: Yingzhen Gao, Liuyi Shen, Tianyue Dong, Xin Yang, Heyang Cui, Yanlin Guo, Yanchun Ma, Pengzhou Kong, Xiaolong Cheng, Ling Zhang and Yongping Cui
    Citation: Journal of Translational Medicine 2022 20:285
  11. Gastric cancer (GC), as one of the most common malignancies across the globe, is the fourth leading cause of cancer-related deaths. Though a large body of research has been conducted to develop the therapeutic...

    Authors: Guohua Jin, Jianguang Zhang, Tingting Cao, Bang Chen, Yu Tian and Yang Shi
    Citation: Journal of Translational Medicine 2022 20:284
  12. Bariatric surgery is an effective therapy for individuals with severe obesity to achieve sustainable weight loss and to reduce comorbidities. Examining the molecular signature of subcutaneous adipose tissue (S...

    Authors: Annie Bouchard-Mercier, Juan de Toro-Martín, Mélanie Nadeau, Odette Lescelleur, Stéfane Lebel, Denis Richard, Laurent Biertho, André Tchernof and Marie-Claude Vohl
    Citation: Journal of Translational Medicine 2022 20:283
  13. Authors: G. C. Mayne, C. M. Woods, N. Dharmawardana, T. Wang, S. Krishnan, J. C. Hodge, A. Foreman, S. Boase, A. S. Carney, E. A. W. Sigston, D. I. Watson, E. H. Ooi and D. J. Hussey
    Citation: Journal of Translational Medicine 2022 20:282

    The original article was published in Journal of Translational Medicine 2020 18:280

  14. Chronic obstructive pulmonary disease (COPD), a prevalent, progressive respiratory disease, has become the third leading cause of death globally. Increasing evidence suggests that intestinal and pulmonary micr...

    Authors: Yu Jia, Tiantian He, Di Wu, Jiabing Tong, Jie Zhu, Zegeng Li and Jingcheng Dong
    Citation: Journal of Translational Medicine 2022 20:281
  15. TIGIT/CD155 has attracted widespread attention as a new immune checkpoint and a potential target for cancer immunotherapy. In our study, we evaluated the role of TIGIT/CD155 checkpoints in the progression of c...

    Authors: Lu Liu, Aihong Wang, Xiaoli Liu, Sai Han, Yu Sun, Junhua Zhang, Lingyu Guo and Youzhong Zhang
    Citation: Journal of Translational Medicine 2022 20:280
  16. Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune ...

    Authors: Hongbing Lin, Huishan Chen, Xuetao Zhao, Tong Ding, Yawei Wang, Zhen Chen, Yue Tian, Peipei Zhang and Yuqin Shen
    Citation: Journal of Translational Medicine 2022 20:279
  17. Adipose tissue homeostasis is at the heart of many metabolic syndromes such as diabetes. Previously it has been demonstrated that adipose tissues from diabetic patients are senescent but whether this contribut...

    Authors: Hao Lin, Xiaonan Chen, Jianan Pan, Jiahan Ke, Alian Zhang, Yangyang Liu, Changqian Wang, Alex Chia Yu Chang and Jun Gu
    Citation: Journal of Translational Medicine 2022 20:278
  18. Glioma is the most common malignant tumors in the brain. Previous studies have revealed that, as the innate immune cells in nervous system, microglia cells were involved in glioma pathology. And, the resident ...

    Authors: Chunlong Zhang, Jiaxin Zhao, Wanqi Mi, Yuxi Zhang, Xiaoling Zhong, Guiyuan Tan, Feng Li, Xia Li, Yanjun Xu and Yunpeng Zhang
    Citation: Journal of Translational Medicine 2022 20:277
  19. Patients with triple-negative breast cancer (TNBC) are better responders to neoadjuvant chemotherapy; however, they are poor in the durability of response with decreased overall and progression-free survival.

    Authors: Zhao-ying Yang, Cheng-wei Jiang, Wen-long Zhang and Guang Sun
    Citation: Journal of Translational Medicine 2022 20:276
  20. Prostate cancer (PCa) is the second most prevalent cancer in males worldwide, yet detecting PCa and its metastases remains a major challenging task in clinical research setups. The present study aimed to chara...

    Authors: Xi Zhang, Binbin Xia, Hong Zheng, Jie Ning, Yinjie Zhu, Xiaoguang Shao, Binrui Liu, Baijun Dong and Hongchang Gao
    Citation: Journal of Translational Medicine 2022 20:275
  21. Radiation-induced skin injury is a well-known risk factor for impaired wound healing. Over time, the deleterious effects of radiation on skin produce a fibrotic, hypovascular dermis poorly suited to wound heal...

    Authors: Hendrik Lintel, Darren B. Abbas, Christopher V. Lavin, Michelle Griffin, Jason L. Guo, Nicholas Guardino, Andrew Churukian, Geoffrey C. Gurtner, Arash Momeni, Michael T. Longaker and Derrick C. Wan
    Citation: Journal of Translational Medicine 2022 20:274
  22. The aim of this study was to explore the tolerability and effect of static stretching (SS) and whole body cryotherapy (WBC) upon fatigue, daytime sleepiness, cognitive functioning and objective and subjective ...

    Authors: Sławomir Kujawski, Joanna Słomko, Beata R. Godlewska, Agnieszka Cudnoch-Jędrzejewska, Modra Murovska, Julia L. Newton, Łukasz Sokołowski and Paweł Zalewski
    Citation: Journal of Translational Medicine 2022 20:273
  23. Ampullary adenocarcinoma (AAC) arises from the ampulla of Vater where the pancreatic duct and bile duct join and empty into the duodenum. It can be classified into intestinal and pancreatobiliary types based o...

    Authors: Jun Cheng, Yize Mao, Wenhui Hong, Wanming Hu, Peng Shu, Kun Huang, Jingjing Yu, Maofen Jiang, Liqin Li, Wei Wang, Dong Ni and Shengping Li
    Citation: Journal of Translational Medicine 2022 20:272
  24. After the success of immunotherapy in the treatment of advanced metastatic cancer, further evaluation in earlier settings, including high-risk, surgically-resectable disease is underway. Potential benefits of ...

    Authors: Elizabeth M. Burton, Rodabe N. Amaria, Tina Cascone, Myriam Chalabi, Neil D. Gross, Elizabeth A. Mittendorf, Richard A. Scolyer, Padmanee Sharma and Paolo A. Ascierto
    Citation: Journal of Translational Medicine 2022 20:271
  25. Heart failure (HF) is a global leading cause of mortality despite implementation of guideline directed therapy which warrants a need for novel treatment strategies. Proof-of-concept clinical trials of anakinra...

    Authors: Benjamin Van Tassell, Virginia Mihalick, Georgia Thomas, Amr Marawan, Azita H. Talasaz, Juan Lu, Le Kang, Amy Ladd, Juan Ignacio Damonte, Dave L. Dixon, Roshanak Markley, Jeremy Turlington, Emily Federmann, Marco Giuseppe Del Buono, Giuseppe Biondi-Zoccai, Justin M. Canada…
    Citation: Journal of Translational Medicine 2022 20:270
  26. The next generation sequencing (NGS) based non-invasive prenatal test (NIPT) has outplayed the traditional serum biochemical tests (SBT) in screen of fetal aneuploidies with a high sensitivity and specificity....

    Authors: Peng Dai, Yanfeng Yang, Ganye Zhao, Zhiqiang Gu, Huanan Ren, Shuang Hu, Ning Liu, Weimeng Jiao, Jinfang Li and Xiangdong Kong
    Citation: Journal of Translational Medicine 2022 20:269
  27. This study aims to provide 12-year nationwide epidemiology data to investigate the epidemiology and comorbidities of and therapeutic options for chronic fatigue syndrome (CFS) by analyzing the National Health ...

    Authors: Kam-Hang Leong, Hei-Tung Yip, Chien-Feng Kuo and Shin-Yi Tsai
    Citation: Journal of Translational Medicine 2022 20:268
  28. Heart failure (HF), as the leading cause of death, is continuing to increase along with the aging of the general population all over the world. Identification of diagnostic biomarkers for early detection of HF...

    Authors: Lu Qian, Qian Zhao, Ping Yu, Jinhui Lü, Yuefan Guo, Xin Gong, Yuanyuan Ding, Shanshan Yu, Lieying Fan, Huimin Fan, Yuzhen Zhang, Zhongmin Liu, Hongzhuan Sheng and Zuoren Yu
    Citation: Journal of Translational Medicine 2022 20:267
  29. Conventional and unconventional lipid parameters are associated with diabetes risk, the comparative studies on lipid parameters for predicting future diabetes risk, however, are still extremely limited, and th...

    Authors: Guotai Sheng, Maobin Kuang, Ruijuan Yang, Yanjia Zhong, Shuhua Zhang and Yang Zou
    Citation: Journal of Translational Medicine 2022 20:266
  30. Sepsis is a life-threatening syndrome eliciting highly heterogeneous host responses. Current prognostic evaluation methods used in clinical practice are characterized by an inadequate effectiveness in predicti...

    Authors: Fei Guo, Xishun Zhu, Zhiheng Wu, Li Zhu, Jianhua Wu and Fan Zhang
    Citation: Journal of Translational Medicine 2022 20:265
  31. Nasopharyngeal carcinoma (NPC) is a malignant tumor of epithelial origin in head and neck with high incidence rate in Southern China. C2orf40 has been identified as a tumor suppressor gene in many cancers. How...

    Authors: Zuozhong Xie, Wei Li, Jingang Ai, Jun Xie and Xiaowei Zhang
    Citation: Journal of Translational Medicine 2022 20:264
  32. Metabolic disorders are associated with increased incidence, aggressive phenotype and poor outcome of breast cancer (BC) patients. For instance, hyperinsulinemia is an independent risk factor for BC and the in...

    Authors: Domenica Scordamaglia, Francesca Cirillo, Marianna Talia, Maria Francesca Santolla, Damiano Cosimo Rigiracciolo, Lucia Muglia, Azzurra Zicarelli, Salvatore De Rosis, Francesca Giordano, Anna Maria Miglietta, Ernestina Marianna De Francesco, Veronica Vella, Antonino Belfiore, Rosamaria Lappano and Marcello Maggiolini
    Citation: Journal of Translational Medicine 2022 20:263
  33. Previous studies have indicated that chronic emotional stressors likely participate in the occurrence of cancers. However, direct evidence connecting stress and colorectal cancer development remains almost com...

    Authors: Zili Zhou, Yan Shu, Haijun Bao, Shengbo Han, Zhengyi Liu, Ning Zhao, Wenzheng Yuan, Chenxing Jian and Xiaogang Shu
    Citation: Journal of Translational Medicine 2022 20:262
  34. High immune infiltration is associated with favourable prognosis in patients with non-small-cell lung cancer (NSCLC), but an automated workflow for characterizing immune infiltration, with high validity and re...

    Authors: Huan Lin, Xipeng Pan, Zhengyun Feng, Lixu Yan, Junjie Hua, Yanting Liang, Chu Han, Zeyan Xu, Yumeng Wang, Lin Wu, Yanfen Cui, Xiaomei Huang, Zhenwei Shi, Xin Chen, Xiaobo Chen, Qingling Zhang…
    Citation: Journal of Translational Medicine 2022 20:261
  35. Lung adenocarcinoma (LUAD) is a heavy social burden worldwide. Because the mechanisms involved in LUAD remain unclear, the prognosis of LUAD remains poor. Consequently, it is urgent to investigate the potentia...

    Authors: Qian Wu, Rui Li, Qing-Xiang Wang, Meng-Yu Zhang, Ting-Ting Liu and Yi-Qing Qu
    Citation: Journal of Translational Medicine 2022 20:260
  36. The aim of this study was to compare Dynamic Susceptibility Contrast Enhanced MRI (DSC-MRI) and PET with [18F]flurodeoxyglucose (FDG-PET) in the diagnosis of Alzheimer’s Disease (AD) and amnestic Mild Cognitiv...

    Authors: Aleksandra Wabik, Elżbieta Trypka, Joanna Bladowska, Mikołaj Statkiewicz, Marek Sąsiadek and Anna Zimny
    Citation: Journal of Translational Medicine 2022 20:259
  37. Ovarian cancer (OC) is a major threat to women’s health. Mesenchymal stem cells (MSCs) are key regulators in cellular communication by secreting extracellular vesicles (EVs) that are involved in OC. This study...

    Authors: Xiaoying Wang, Lili Jiang and Qifang Liu
    Citation: Journal of Translational Medicine 2022 20:258
  38. Over the past decade, immunotherapy has become an increasingly fundamental modality in the treatment of cancer. The positive impact of immune checkpoint inhibition, especially anti-programmed death (PD)-1/PD-l...

    Authors: Paolo A. Ascierto, Antonio Avallone, Nina Bhardwaj, Carlo Bifulco, Sergio Bracarda, Joshua D. Brody, Luigi Buonaguro, Sandra Demaria, Leisha A. Emens, Robert L. Ferris, Jérôme Galon, Samir N. Khleif, Christopher A. Klebanoff, Tamara Laskowski, Ignacio Melero, Chrystal M. Paulos…
    Citation: Journal of Translational Medicine 2022 20:257
  39. We established a radiogenomic model to predict pathological complete response (pCR) in triple-negative breast cancer (TNBC) and explored the association between high-frequency mutations and drug resistance.

    Authors: Ying Zhang, Chao You, Yuchen Pei, Fan Yang, Daqiang Li, Yi-zhou Jiang and Zhimin Shao
    Citation: Journal of Translational Medicine 2022 20:256
  40. Lymphatic metastasis was an independent prognostic risk factor for hypopharyngeal carcinoma and was the main cause of treatment failure. The purpose of this study was to screen the differential genes and inves...

    Authors: Yanshi Li, Min Pan, Tao Lu, Dan Yu, Chuan Liu, Zhihai Wang and Guohua Hu
    Citation: Journal of Translational Medicine 2022 20:255
  41. There are sudden deterioration phenomena during the progression of many complex diseases, including most cancers; that is, the biological system may go through a critical transition from one stable state (the ...

    Authors: Juntan Liu, Dandan Ding, Jiayuan Zhong and Rui Liu
    Citation: Journal of Translational Medicine 2022 20:254
  42. We hypothesized that a gender difference in clinical response may exist to adjuvant CTLA4 blockade with ipilimumab versus high-dose IFNα (HDI). We investigated differences in candidate immune biomarkers in the...

    Authors: Mariam Saad, Sandra J. Lee, Aik Choon Tan, Issam M. El Naqa, F. Stephen Hodi, Lisa H. Butterfield, William A. LaFramboise, Walter Storkus, Arivarasan D. Karunamurthy, Jose Conejo-Garcia, Patrick Hwu, Howard Streicher, Vernon K. Sondak, John M. Kirkwood and Ahmad A. Tarhini
    Citation: Journal of Translational Medicine 2022 20:253
  43. Senescent cells have been identified in the aging prostate, and the senescence-associated secretory phenotype might be linked to prostate cancer (PCa). Thus, we established a cellular senescence-related gene p...

    Authors: Dechao Feng, Dengxiong Li, Xu Shi, Qiao Xiong, Facai Zhang, Qiang Wei and Lu Yang
    Citation: Journal of Translational Medicine 2022 20:252
  44. Nicotinamide (NAM, a variant of vitamin B3) has recently been shown to accelerate the activation of human CD4+ and CD8+ T cells exposed to repeated CD3/CD28 agonism in vitro. Here, we demonstrate that T cells inf...

    Authors: Yang Hu, Norma Bloy, Olivier Elemento and Aitziber Buqué
    Citation: Journal of Translational Medicine 2022 20:251
  45. Gastric cancer is a common type of gastrointestinal malignant tumor in China. The mechanism of the development and progression of gastric cancer remains the continuing research focus. The tumor microenvironmen...

    Authors: Weihua Yu, Guojun Chen, Jiafei Yan, Xianfa Wang, Yiping Zhu and Linghua Zhu
    Citation: Journal of Translational Medicine 2022 20:250
  46. mTOR pathway is known to promote cancer malignancy and influence cancer immunity but is unknown for its role in immune checkpoint inhibitors (ICI) therapy.

    Authors: Lei Cheng, Yanan Wang, Lixin Qiu, Yuanyuan Chang, Haijiao Lu, Chenchen Liu, Bo Zhang, Yan Zhou, Hao Bai, Liwen Xiong, Hua Zhong, Wei Nie and Baohui Han
    Citation: Journal of Translational Medicine 2022 20:247
  47. Platinum based agents—cisplatin and carboplatin in combination with taxanes are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC patients develop recurrent, platinum resistan...

    Authors: Shruthi Sriramkumar, Riddhi Sood, Thomas D. Huntington, Ahmed H. Ghobashi, Truc T. Vuong, Tara X. Metcalfe, Weini Wang, Kenneth P. Nephew and Heather M. O’Hagan
    Citation: Journal of Translational Medicine 2022 20:246

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