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  1. Pharmacogenomics (PGx) aims to utilize a patient’s genetic data to enable safer and more effective prescribing of medications. The Clinical Pharmacogenetics Implementation Consortium (CPIC) provides guidelines...

    Authors: Shefali S. Verma, Karl Keat, Binglan Li, Glenda Hoffecker, Marjorie Risman, Katrin Sangkuhl, Michelle Whirl-Carrillo, Scott Dudek, Anurag Verma, Teri E. Klein, Marylyn D. Ritchie and Sony Tuteja
    Citation: Journal of Translational Medicine 2022 20:550
  2. The COVID-19 pandemic has become a huge threat to human health, infecting millions of people worldwide and causing enormous economic losses. Many novel small molecule drugs have been developed to treat patient...

    Authors: Keyu Kong, Yongyun Chang, Hua Qiao, Chen Zhao, Xuzhuo Chen, Kewei Rong, Pu Zhang, Minghao Jin, Jingwei Zhang, Huiwu Li and Zanjing Zhai
    Citation: Journal of Translational Medicine 2022 20:549
  3. Acute lung injury (ALI) occurs in 23% unilateral. Models of unilateral ALI were developed and used previously without clearly demonstrating the strictly unilateral nature and severity of lung injury by the key...

    Authors: Johannes Geilen, Matthias Kainz, Bernhard Zapletal, Silvana Geleff, Wilfried Wisser, Barbara Bohle, Thomas Schweiger, Marcus J. Schultz and Edda Tschernko
    Citation: Journal of Translational Medicine 2022 20:548
  4. Accumulating evidence supports the implication of circular RNAs (circRNAs) in systemic lupus erythematosus (SLE). However, little is known about the detailed mechanisms and roles of circRNAs in the pathogenesi...

    Authors: Xingwang Zhao, Rui Dong, Zhongwei Tang, Juan Wang, Chunyou Wang, Zhiqiang Song, Bing Ni, Longlong Zhang, Xiaochong He and Yi You
    Citation: Journal of Translational Medicine 2022 20:547
  5. Sepsis-associated encephalopathy (SAE) is one of the most common types of sepsis-related organ dysfunction without overt central nervous system (CNS) infection. It is associated with higher mortality, low qual...

    Authors: John Sieh Dumbuya, Siqi Li, Lili Liang, Yanchen Chen, Jiang Du and Qiyi Zeng
    Citation: Journal of Translational Medicine 2022 20:546
  6. This study aimed to analyze the clinical outcomes of blastocyst which undergo the preimplantation genetic testing (PGT) transplantation from frozen-thawed D5 and D6. In addition, the effect of blastocyst grade...

    Authors: Guanling Yu, Shuiying Ma, Hui Liu, Yujin Liu, Haozhen Zhang, Wenjia Zhang and Keliang Wu
    Citation: Journal of Translational Medicine 2022 20:545
  7. Arteriovenous fistula (AVF) maturation is a process involving remodeling of venous arm of the AVFs. It is a challenge to balance adaptive AVF remodeling and neointima formation. In this study we temporally con...

    Authors: Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang and Jizhong Cheng
    Citation: Journal of Translational Medicine 2022 20:543
  8. Despite the recent progress in the treatment and outcome of Non Small Cell Lung Cancer (NSCLC), immunotherapy has still significant limitations reporting a significant proportion of patients not benefiting fro...

    Authors: Carminia Maria Della Corte, Vincenza Ciaramella, Kavya Ramkumar, Giovanni Vicidomini, Alfonso Fiorelli, Valerio Nardone, Salvatore Cappabianca, Immacolata Cozzolino, Federica Zito Marino, Gaetano Di Guida, Qi Wang, Robert Cardnell, Carl Michael Gay, Davide Ciardiello, Erika Martinelli, Teresa Troiani…
    Citation: Journal of Translational Medicine 2022 20:541
  9. In recent years, the biological role of changes in physical factors in carcinogenesis and progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is a critical physical fact...

    Authors: Boer Deng, Ziyi Zhao, Weimin Kong, Chao Han, Xiaochang Shen and Chunxiao Zhou
    Citation: Journal of Translational Medicine 2022 20:540
  10. Posttranslational protein modifications regulate essential cellular processes, including the immune cell activation. Despite known age-related alterations of the phenotype, composition and cytokine profiles of...

    Authors: Georgiana Toma, Eliza Karapetian, Chiara Massa, Dagmar Quandt and Barbara Seliger
    Citation: Journal of Translational Medicine 2022 20:539
  11. Extracorporeal blood purification therapies targeting removal of the downstream products of the inflammatory cascade in sepsis have failed to improve mortality. As an upstream process of the inflammatory casca...

    Authors: Lei Zhou, Dong Zhang, Ling Kong, Xiaodong Xu and Dehua Gong
    Citation: Journal of Translational Medicine 2022 20:538
  12. Multiple myeloma (MM) is a malignancy of plasma cells that remains incurable. Toll-like receptor 4 (TLR4) acts as a stress-responsive signal, protecting mitochondria during proteasome inhibitor (PI) exposure, ...

    Authors: Lina Quan, Chuiming Jia, Yiwei Guo, Yao Chen, Xinya Wang, Qiuting Xu and Yu Zhang
    Citation: Journal of Translational Medicine 2022 20:537
  13. Chromosomal aneuploidy is the most common birth defect. However, the developmental mechanism and gene expression profile of fetuses with chromosomal aneuploidy are relatively unknown, and the maternal immune c...

    Authors: Min Zhang, Kun Li, Shoufang Qu, Zhiwei Guo, Yuanli Wang, Xu Yang, Junhua Zhou, Guojun Ouyang, Rongtao Weng, Fenxia Li, Yingsong Wu and Xuexi Yang
    Citation: Journal of Translational Medicine 2022 20:536
  14. Abnormal gene expression level or expression of genes containing deleterious mutations are two of the main determinants which lead to genetic disease. To obtain a therapeutic effect and thus to cure genetic di...

    Authors: Hsing-Chuan Tsai, Violena Pietrobon, Maoyu Peng, Suning Wang, Lihong Zhao, Francesco M. Marincola and Qi Cai
    Citation: Journal of Translational Medicine 2022 20:535
  15. Gene editing has great potential in treating diseases caused by well-characterized molecular alterations. The introduction of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associate...

    Authors: Ajaz A. Bhat, Sabah Nisar, Soumi Mukherjee, Nirmalya Saha, Nageswari Yarravarapu, Saife N. Lone, Tariq Masoodi, Ravi Chauhan, Selma Maacha, Puneet Bagga, Punita Dhawan, Ammira Al-Shabeeb Akil, Wael El-Rifai, Shahab Uddin, Ravinder Reddy, Mayank Singh…
    Citation: Journal of Translational Medicine 2022 20:534
  16. Circular ribonucleic acids (circRNAs) are a class of long non-coding RNA that were once regarded as non-functional transcription byproducts. However, recent studies suggested that circRNAs may exhibit importan...

    Authors: Ryan Wong, Yiwen Zhang, Hailin Zhao and Daqing Ma
    Citation: Journal of Translational Medicine 2022 20:533
  17. The crosstalk of purine biosynthesis and metabolism exists to balance the cell energy production, proliferation, survival and cytoplasmic environment stability, but disorganized mechanics of with respect to de...

    Authors: Ge Wang, Rongjun Zou, Libao Liu, Zongtao Wang, Zengxiao Zou, Songtao Tan, Wenliu Xu and Xiaoping Fan
    Citation: Journal of Translational Medicine 2022 20:532
  18. Non-small cell lung cancer (NSCLC) is the most widely distributed tumor in the world, and its immunotherapy is not practical. Neutrophil is one of a tumor’s most abundant immune cell groups. This research aime...

    Authors: Jianyu Pang, Qian Yu, Yongzhi Chen, Hongjun Yuan, Miaomiao Sheng and Wenru Tang
    Citation: Journal of Translational Medicine 2022 20:531
  19. Liver cancer is the fifth leading cause of cancer death worldwide, but early diagnosis and treatment of liver cancer remains a clinical challenge. How to screen and diagnose liver cancer early and prolong the ...

    Authors: Lihua Wang, Zheng Zhu, Qi Liang, Yecheng Tao, Gaowei Jin, Yaoyao Zhong, Jichen Dai, Ruixia Dai, Zhixiang Wang, Junbo Chen, Lingjie Zhou, Shouyu Ke, Bin Zheng, Linhua Lan, Xiaokun Lin and Tongke Chen
    Citation: Journal of Translational Medicine 2022 20:530
  20. Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder with abnormal lipid metabolism. The present study was to identify regulatory genes related to lipid droplets (LDs) abnormal accumulation in NAFLD.

    Authors: Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan and Jiequn Li
    Citation: Journal of Translational Medicine 2022 20:529
  21. MICAL1 is involved in the malignant processes of several types of cancer; however, the role of MICAL1 in pancreatic cancer (PC) has not been well-characterized. This study aimed to investigate the expression a...

    Authors: Kun Cai, Lu Deng, Dijie Zheng, Lin Li, Zhiwei He and Chao Yu
    Citation: Journal of Translational Medicine 2022 20:528
  22. The role of the inflammatory milieu in prostate cancer progression is not well understood. Differences in inflammatory signaling between localized and metastatic disease may point to opportunities for early in...

    Authors: Ida Deichaite, Timothy J. Sears, Leisa Sutton, Daniel Rebibo, Kylie Morgan, Tyler Nelson, Brent Rose, Pablo Tamayo, Napoleone Ferrara, Fotis Asimakopoulos and Hannah Carter
    Citation: Journal of Translational Medicine 2022 20:527
  23. COVID-19 infections could be complicated by acute respiratory distress syndrome (ARDS), increasing mortality risk. We sought to assess the methylome of peripheral blood mononuclear cells in COVID-19 with ARDS.

    Authors: Martina Bradic, Sarah Taleb, Binitha Thomas, Omar Chidiac, Amal Robay, Nessiya Hassan, Joel Malek, Ali Ait Hssain and Charbel Abi Khalil
    Citation: Journal of Translational Medicine 2022 20:526
  24. Non-small cell lung cancer (NSCLC) is the most common lung cancer with high mortality across the world, but it is challenging to develop an effective therapy for NSCLC. Celastrol is a natural bioactive compoun...

    Authors: Zhucheng Zhao, Yanmao Wang, Yuyan Gong, Xian Wang, Luyao Zhang, Haiyang Zhao, Jifa Li, Jiandong Zhu, Xiaoying Huang, Chengguang Zhao, Lehe Yang and Liangxing Wang
    Citation: Journal of Translational Medicine 2022 20:525
  25. This paper intends to propose a method of using TransResSEUnet2.5D network for accurate automatic segmentation of the Gross Target Volume (GTV) in Radiotherapy for lung cancer.

    Authors: Hui Xie, Zijie Chen, Jincheng Deng, Jianfang Zhang, Hanping Duan and Qing Li
    Citation: Journal of Translational Medicine 2022 20:524
  26. Pulmonary fibrosis is a chronic progressive fibrotic interstitial lung disease characterized by excessive extracellular matrix (ECM) deposition caused by activated fibroblasts. Increasing evidence shows that m...

    Authors: Demin Cheng, Ziwei Li, Yue Wang, Haojie Xiong, Wenqing Sun, Siyun Zhou, Yi Liu and Chunhui Ni
    Citation: Journal of Translational Medicine 2022 20:523
  27. Cardiac mesenchymal stromal cells (C-MSC) were recently shown to differentiate into adipocytes and myofibroblasts to promote the aberrant remodeling of cardiac tissue that characterizes arrhythmogenic cardiomy...

    Authors: Angela S. Maione, Pawan Faris, Lara Iengo, Valentina Catto, Luca Bisonni, Francesco Lodola, Sharon Negri, Michela Casella, Anna Guarino, Gianluca Polvani, Marina Cerrone, Claudio Tondo, Giulio Pompilio, Elena Sommariva and Francesco Moccia
    Citation: Journal of Translational Medicine 2022 20:522
  28. We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism. We wished to decipher the PARP-1/STAT...

    Authors: Jeffrey Wang, Mohamed A. Ghonim, Salome V. Ibba, Hanh H. Luu, Yucel Aydin, Peter A. Greer and A. Hamid Boulares
    Citation: Journal of Translational Medicine 2022 20:521
  29. The tumour microenvironment and cirrhotic liver are excellent sources of cancer-associated fibroblasts (CAFs), which participate in carcinogenesis. Thus, it is important to clarify the crosstalk between CAFs a...

    Authors: Jungang Zhao, Rizhao Li, Jiacheng Li, Ziyan Chen, Zixia Lin, Baofu Zhang, Liming Deng, Gang Chen and Yi Wang
    Citation: Journal of Translational Medicine 2022 20:520
  30. Chronic graft-versus-host disease (GVHD) is a major cause of late morbidity and non-relapse mortality in recipients of allogeneic hematopoietic cell transplantation (HCT). Its biology, however, remains poorly ...

    Authors: Alain Mina, Lauren Curtis, Kamille West, Yu Ying Yau, Edward W. Cowen, Frances Hakim and Steven Z. Pavletic
    Citation: Journal of Translational Medicine 2022 20:519
  31. Identifying patterns of variation in obesity indices and other cardiometabolic risk factors before the diagnosis of type 2 diabetes could provide insight into the critical period when drastic changes occurred ...

    Authors: Fatemeh Koohi, Nooshin Ahmadi, Fereidoun Azizi, Davood Khalili and Majid Valizadeh
    Citation: Journal of Translational Medicine 2022 20:518
  32. Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscular disorder characterized by asymmetric muscle wasting and weakness. FSHD can be subdivided into two types: FSHD1, caused by contrac...

    Authors: Yosuke Hiramuki, Yuriko Kure, Yoshihiko Saito, Megumu Ogawa, Keiko Ishikawa, Madoka Mori-Yoshimura, Yasushi Oya, Yuji Takahashi, Dae-Seong Kim, Noriko Arai, Chiaki Mori, Tsuyoshi Matsumura, Tadanori Hamano, Kenichiro Nakamura, Koji Ikezoe, Shinichiro Hayashi…
    Citation: Journal of Translational Medicine 2022 20:517
  33. Cellular compositions of solid tumor microenvironments are heterogeneous, varying across patients and tumor types. High-resolution profiling of the tumor microenvironment cell composition is crucial to underst...

    Authors: Ze Zhang, John K. Wiencke, Karl T. Kelsey, Devin C. Koestler, Brock C. Christensen and Lucas A. Salas
    Citation: Journal of Translational Medicine 2022 20:516
  34. Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the destruction of the articular cartilage, sclerosis of the subchondral bone, and joint dysfunction. Its pathogenesis is attributed...

    Authors: Jianghong Huang, Qisong Liu, Jiang Xia, Xi Chen, Jianyi Xiong, Lei Yang and Yujie Liang
    Citation: Journal of Translational Medicine 2022 20:515
  35. Clinical CAR T-cell therapy using integrating vector systems represents a promising approach for the treatment of hematological malignancies. Lentiviral and γ-retroviral vectors are the most commonly used vect...

    Authors: Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch…
    Citation: Journal of Translational Medicine 2022 20:514
  36. Despite a recent increase in the number of RNA-seq datasets investigating heart failure (HF), accessibility and usability remain critical issues for medical researchers. We address the need for an intuitive an...

    Authors: Thiago Britto-Borges, Annekathrin Ludt, Etienne Boileau, Enio Gjerga, Federico Marini and Christoph Dieterich
    Citation: Journal of Translational Medicine 2022 20:513
  37. Pancreatic cancer (PC) is a highly malignant tumor which threatens human’s health. Long non-coding RNAs (lncRNAs) are implicated in many cancers, including PC, but their mechanisms in PC have not yet been enti...

    Authors: Dandan Yu, Zhigang Zhao, Li Wang, Shishi Qiao, Zhen Yang, Qiang Wen and Guanghui Zhu
    Citation: Journal of Translational Medicine 2022 20:511
  38. Diabetic kidney disease (DKD) is among the most important causes for chronic kidney disease. Anthocyanins (ANT) are polyphenolic compounds present in various food and play an important role in ameliorating hyp...

    Authors: Yi-Xi Li, Yong-Ping Lu, Donge Tang, Bo Hu, Ze-Yu Zhang, Hong-Wei Wu, Li-Jing Fan, Kai-Wen Cai, Chun Tang, Yi-Qing Zhang, Ling Hong, Jing-jing Dong, Bao-zhang Guan, Liang-Hong Yin, Yong Dai, Wei-bin Bai…
    Citation: Journal of Translational Medicine 2022 20:510
  39. Angiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin-angiotensin system and a well-known functional receptor for the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into ho...

    Authors: Xiaoyan Zuo, Sixin Ren, He Zhang, Jianfei Tian, Ruinan Tian, Baoai Han, Hui Liu, Qian Dong, Zhiyong Wang, Yanfen Cui, Ruifang Niu and Fei Zhang
    Citation: Journal of Translational Medicine 2022 20:509
  40. The metastatic mechanisms of axillary lymph nodes (ALNs) in triple-negative breast cancer (TNBC) remain unclear. We aimed to identify the potential circRNA regulatory network in ALN metastasis.

    Authors: Jiayue Luo, Dong Cao, Chuwen Hu, Zhen Liang, Yuanping Zhang and Jianguo Lai
    Citation: Journal of Translational Medicine 2022 20:508
  41. Radioresistance is a major cause of treatment failure in esophageal squamous cell carcinoma (ESCC) radiotherapy, and the underlying mechanisms of radioresistance are still unclear. Irradiation (IR) stimulates ...

    Authors: Xingyu Du, Xueyuan Zhang, Jing Dong, Naiyi Zou, Dong Guo, Weinan Yao, Xiaobin Wang, Shuguang Li, Chunyang Song, Ke Yan, Wenbin Shen and Shuchai Zhu
    Citation: Journal of Translational Medicine 2022 20:507
  42. Immune checkpoint inhibitors are promising tools in combating several cancers, including head and neck squamous cell carcinoma (HNSCC). However, a substantial portion of HNSCC patients do not respond to PD-L1 ...

    Authors: Shuang Li, Ding Wang, Jinzhang Cheng, Jicheng Sun, Dhan V. Kalvakolanu, Xue Zhao, Di Wang, Yunhan You, Ling Zhang and Dan Yu
    Citation: Journal of Translational Medicine 2022 20:505
  43. Periodontitis is a major inflammatory disease of the oral mucosa that is not limited to the oral cavity but also has systemic consequences. Although the importance of chronic periodontitis has been emphasized,...

    Authors: Hansong Lee, Ji-Young Joo, Dong Hyun Sohn, Junho Kang, Yeuni Yu, Hae Ryoun Park and Yun Hak Kim
    Citation: Journal of Translational Medicine 2022 20:504
  44. Autologous hematopoietic progenitor cell (HPC) transplantation is currently the standard of care for a fraction of patients with newly diagnosed myelomas and relapsed or refractory lymphomas. After high-dose c...

    Authors: Bechara Mfarrej, Olivier Vicari, Sarah Ouffai, Carine Malenfant, Angela Granata, Sophie Thevenet, Christian Chabannon, Claude Lemarié and Boris Calmels
    Citation: Journal of Translational Medicine 2022 20:503
  45. The genetic architecture underlying Familial Hypercholesterolemia (FH) in Middle Eastern Arabs is yet to be fully described, and approaches to assess this from population-wide biobanks are important for public...

    Authors: Geethanjali Devadoss Gandhi, Waleed Aamer, Navaneethakrishnan Krishnamoorthy, Najeeb Syed, Elbay Aliyev, Aljazi Al-Maraghi, Muhammad Kohailan, Jamil Alenbawi, Mohammed Elanbari, Borbala Mifsud, Younes Mokrab, Charbel Abi Khalil and Khalid A. Fakhro
    Citation: Journal of Translational Medicine 2022 20:502
  46. Previous studies on European (EUR) samples have obtained inconsistent results regarding the genetic correlation between type 2 diabetes mellitus (T2DM) and Schizophrenia (SCZ). A large-scale trans-ethnic genet...

    Authors: Lei Cai, Yanlan Sun, Yonglin Liu, Wenzhong Chen, Lin He and Dong-Qing Wei
    Citation: Journal of Translational Medicine 2022 20:501

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