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  1. Because of limitations of transportation imposed by the COVID-19 pandemic, current recommendation calls for cryopreservation of allogeneic stem cell transplants before patient conditioning. A single cell thera...

    Authors: Eliza Wiercinska, Vera Schlipfenbacher, Gesine Bug, Peter Bader, Mareike Verbeek, Erhard Seifried and Halvard Bonig

    Citation: Journal of Translational Medicine 2021 19:145

    Content type: Research

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  2. As part of the 2020 Immunotherapy Bridge virtual congress (December 2nd–3rd, Italy), the Great Debate session featured counterpoint views from leading experts on three clinical questions in immunotherapy today...

    Authors: Paolo A. Ascierto, Joshua Brody, Lisa H. Butterfield, Olivera J. Finn, John Goldberg, Francesco Perrone, Ryan J. Sullivan, Bernard A. Fox, Patrick Hwu and Igor Puzanov

    Citation: Journal of Translational Medicine 2021 19:144

    Content type: Meeting report

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  3. Glioma is a complex cancer with a high morbidity and high mortality. Bone marrow mesenchymal stem cells (BMSCs) have shown promise as an excellent cell/drug delivery vehicle for gene-targeted therapy; however,...

    Authors: Jianjun Wu, Shoupin Xie, Hailong Li, Yanxia Zhang, Jia Yue, Chunlu Yan, Kai Liu, Yongqi Liu, Rui Xu and Guisen Zheng

    Citation: Journal of Translational Medicine 2021 19:143

    Content type: Research

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  4. The Great Debate session at the 2020 Melanoma Bridge virtual congress (December 3rd–5th, Italy) featured counterpoint views from experts on five specific controversial issues in melanoma. The debates considere...

    Authors: Paolo A. Ascierto, Michael B. Atkins, Alexander M. Eggermont, Jeffrey E. Gershenwald, Jean-Jacques Grob, Omid Hamid, Vernon K. Sondak, Jeffrey A. Sosman, Hussein A. Tawbi, Jeffrey S. Weber, Corrado Caracò, Iman Osman and Igor Puzanov

    Citation: Journal of Translational Medicine 2021 19:142

    Content type: Meeting report

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  5. Due to insufficient accuracy, urine-based assays currently have a limited role in the management of patients with bladder cancer. The identification of multiplex molecular signatures associated with disease ha...

    Authors: Yosuke Hirasawa, Ian Pagano, Runpu Chen, Yijun Sun, Yunfeng Dai, Amit Gupta, Sergei Tikhonenkov, Steve Goodison, Charles J. Rosser and Hideki Furuya

    Citation: Journal of Translational Medicine 2021 19:141

    Content type: Research

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  6. Low T3 syndrome is frequent in patients admitted to intensive care units for critical illness and pneumonia. It has been reported also in patients with COVID-19, Hodgkin disease and chronic lymphocytic leukemi...

    Authors: Salvatore Sciacchitano, Claudia De Vitis, Michela D’Ascanio, Simonetta Giovagnoli, Chiara De Dominicis, Andrea Laghi, Paolo Anibaldi, Andrea Petrucca, Gerardo Salerno, Iolanda Santino, Rachele Amodeo, Maurizio Simmaco, Christian Napoli, Agostino Tafuri, Arianna Di Napoli, Andrea Sacconi…

    Citation: Journal of Translational Medicine 2021 19:139

    Content type: Research

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  7. Type 1 diabetes affects millions of people globally and requires careful management to avoid serious long-term complications, including heart and kidney disease, stroke, and loss of sight. The type 1 diabetes ...

    Authors: Ammira Al-Shabeeb Akil, Esraa Yassin, Aljazi Al-Maraghi, Elbay Aliyev, Khulod Al-Malki and Khalid A. Fakhro

    Citation: Journal of Translational Medicine 2021 19:137

    Content type: Review

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  8. Long noncoding RNAs (lncRNAs) can regulate gene expression in a cis-regulatory fashion or as “microRNA sponges”. However, the expression and functions of lncRNAs during early human immunodeficiency virus (HIV) in...

    Authors: Lianwei Ma, Hui Zhang, Yue Zhang, Hailong Li, Minghui An, Bin Zhao, Haibo Ding, Junjie Xu, Hong Shang and Xiaoxu Han

    Citation: Journal of Translational Medicine 2021 19:135

    Content type: Research

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  9. Migraine and depression are highly prevalent and partly overlapping disorders that cause strong limitations in daily life. Patients tend to respond poorly to the therapies available for these diseases. Onabotu...

    Authors: Oreste Affatato, Thiago C. Moulin, Claudia Pisanu, Victoria S. Babasieva, Marco Russo, Elif I. Aydinlar, Paola Torelli, Vladimir N. Chubarev, Vadim V. Tarasov, Helgi B. Schiöth and Jessica Mwinyi

    Citation: Journal of Translational Medicine 2021 19:133

    Content type: Review

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  10. Coronavirus disease 2019 (COVID-19) global pandemic has created unique challenges to healthcare systems throughout the world. Ensuring subjects’ safety is mandatory especially in oncology, in consideration of ...

    Authors: Maria Antonietta Isgrò, Maria Grazia Vitale, Egidio Celentano, Flavia Nocerino, Giuseppe Porciello, Marcello Curvietto, Domenico Mallardo, Concetta Montagnese, Luigi Russo, Nicoletta Zanaletti, Antonio Avallone, Matilde Pensabene, Michelino De Laurentiis, Sara Centonze, Sandro Pignata, Lucia Cannella…

    Citation: Journal of Translational Medicine 2021 19:132

    Content type: Research

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  11. Steroid resistant (SR) nephrotic syndrome (NS) affects up to 30% of children and is responsible for fast progression to end stage renal disease. Currently there is no early prognostic marker of SR and studied ...

    Authors: Katarzyna Zaorska, Piotr Zawierucha, Monika Świerczewska, Danuta Ostalska-Nowicka, Jacek Zachwieja and Michał Nowicki

    Citation: Journal of Translational Medicine 2021 19:130

    Content type: Research

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  12. Coronavirus disease (COVID-19) pandemic has affected health and lifestyle behaviors of people globally. This project aims to identify the impact of COVID-19 on lifestyle behavior of individuals in the Middle E...

    Authors: Mohamed Abouzid, Dina M. El-Sherif, Nael Kamel Eltewacy, Nesrine Ben Hadj Dahman, Salah A. Okasha, Sherief Ghozy and Sheikh Mohammed Shariful Islam

    Citation: Journal of Translational Medicine 2021 19:129

    Content type: Research

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  13. Omega-3 polyunsaturated fatty acids (n3-PUFAs) may exert beneficial effects on the immune system of patients with viral infections. This paper aimed to examine the effect of n3-PUFA supplementation on inflamma...

    Authors: Saeid Doaei, Somayeh Gholami, Samira Rastgoo, Maryam Gholamalizadeh, Fatemeh Bourbour, Seyedeh Elaheh Bagheri, Forough Samipoor, Mohammad Esmail Akbari, Mahdi Shadnoush, Fereshteh Ghorat, Seyed Alireza Mosavi Jarrahi, Narjes Ashouri Mirsadeghi, Azadeh Hajipour, Parvin Joola, Alireza Moslem and Mark O. Goodarzi

    Citation: Journal of Translational Medicine 2021 19:128

    Content type: Research

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  14. Lung cancer is the most common cancer and cause of cancer‐related mortality worldwide, increasing evidence indicated that there was a significant correlation between tumors and the long non‐coding RNAs (lncRNA...

    Authors: Lan Mu, Ke Ding, Ranran Tu and Wei Yang

    Citation: Journal of Translational Medicine 2021 19:127

    Content type: Research

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  15. As the fourth leading cause of cancer-related death in the world, the therapeutic effect and 5-year overall survival of hepatocellular carcinoma (HCC) are not optimistic. Previous researches indicated that the...

    Authors: Mingxing Xu, Jianliang Xu, Dun Zhu, Rishun Su, Baoding Zhuang, Ruiyun Xu, Lingli Li, Shuxian Chen and Yunbiao Ling

    Citation: Journal of Translational Medicine 2021 19:126

    Content type: Research

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  16. Tumor invasiveness reflects many biological changes associated with tumorigenesis, progression, metastasis, and drug resistance. Therefore, we performed a systematic assessment of invasiveness-related molecula...

    Authors: Guoshu Bi, Jiaqi Liang, Yuansheng Zheng, Runmei Li, Mengnan Zhao, Yiwei Huang, Cheng Zhan, Songtao Xu and Hong Fan

    Citation: Journal of Translational Medicine 2021 19:124

    Content type: Research

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  17. As a common haematological malignancy, acute myeloid leukaemia (AML), particularly with extramedullary infiltration (EMI), often results in a high mortality rate and poor prognosis. Circular RNAs (circRNAs) re...

    Authors: Leilei Lin, Yu Wang, Sicheng Bian, Lili Sun, Zhibo Guo, Desheng Kong, Linlin Zhao, Dan Guo, Qi Li, Min Wu, Yuhuang Wang, Yuying Wang and Yinghua Li

    Citation: Journal of Translational Medicine 2021 19:123

    Content type: Research

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  18. Discovering potential predictive risks in the super precarcinomatous phase of hepatocellular carcinoma (HCC) without any clinical manifestations is impossible under normal paradigm but critical to control this...

    Authors: Yinying Chen, Wei Yang, Qilong Chen, Qiong Liu, Jun Liu, Yingying Zhang, Bing Li, Dongfeng Li, Jingyi Nan, Xiaodong Li, Huikun Wu, Xinghua Xiang, Yehui Peng, Jie Wang, Shibing Su and Zhong Wang

    Citation: Journal of Translational Medicine 2021 19:122

    Content type: Research

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  19. Chronic obstructive pulmonary disease (COPD) is a progressive, life-threatening lung disease with increasing prevalence and incidence worldwide. Increasing evidence suggests that lung microbiomes might play a ...

    Authors: Chia-Yu Yang, Shiao-Wen Li, Chia-Yin Chin, Chia-Wei Hsu, Chi-Ching Lee, Yuan-Ming Yeh and Kuo-An Wu

    Citation: Journal of Translational Medicine 2021 19:121

    Content type: Research

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  20. CKLF like MARVEL transmembrane domain containing 6 (CMTM6) has been associated with the development in many kinds of cancers. However, the roles of CMTM6 in hepatocellular carcinoma (HCC) are largely unknown. ...

    Authors: Xiaoting Huang, Leyang Xiang, Baiyao Wang, Jijie Hu, Chunshan Liu, Anbang Ren, Kunpeng Du, Gengtai Ye, Yingying Liang, Yunqiang Tang, Dinghua Yang and Yawei Yuan

    Citation: Journal of Translational Medicine 2021 19:120

    Content type: Research

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  21. The response to immunotherapy can be impaired by several factors including external intervention such as drug interactions with immune system. We aimed to examine the immunomodulatory action of opioids, since ...

    Authors: Andrea Botticelli, Alessio Cirillo, Giulia Pomati, Bruna Cerbelli, Simone Scagnoli, Michela Roberto, Alain Gelibter, Giulia Mammone, Maria Letizia Calandrella, Edoardo Cerbelli, Francesca Romana Di Pietro, Federica De Galitiis, Gaetano Lanzetta, Enrico Cortesi, Silvia Mezi and Paolo Marchetti

    Citation: Journal of Translational Medicine 2021 19:119

    Content type: Research

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  22. Glucose-regulating protein 78 (GRP78) is a molecular chaperone in the endoplasmic reticulum (ER) that promotes folding and assembly of proteins, controls the quality of proteins, and regulates ER stress signal...

    Authors: Shengkai Xia, Wenzhe Duan, Wenwen Liu, Xinri Zhang and Qi Wang

    Citation: Journal of Translational Medicine 2021 19:118

    Content type: Review

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  23. Epigenetic dysregulation plays important roles in leukemogenesis and the progression of acute myeloid leukemia (AML). Histone acetyltransferases (HATs) and histone deacetylases (HDACs) reciprocally regulate th...

    Authors: Xuejie Jiang, Ling Jiang, Jiaying Cheng, Fang Chen, Jinle Ni, Changxin Yin, Qiang Wang, Zhixiang Wang, Dan Fang, Zhengshan Yi, Guopan Yu, Qingxiu Zhong, Bing Z. Carter and Fanyi Meng

    Citation: Journal of Translational Medicine 2021 19:117

    Content type: Research

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  24. The ability to approximate intra-operative hemoglobin loss with reasonable precision and linearity is prerequisite for determination of a relevant surgical outcome parameter: This information enables compariso...

    Authors: Max Hahn-Klimroth, Philipp Loick, Soo-Zin Kim-Wanner, Erhard Seifried and Halvard Bonig

    Citation: Journal of Translational Medicine 2021 19:116

    Content type: Research

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  25. Muscle wasting, low protein intake, hypoalbuminemia, low body mass, and chronic fatigue are prevalent in hemodialysis patients. Impaired creatine status may be an often overlooked, potential contributor to the...

    Authors: Adrian Post, Joëlle C. Schutten, Daan Kremer, Yvonne van der Veen, Dion Groothof, Camilo G. Sotomayor, Christa A. Koops, Pim de Blaauw, Ido P. Kema, Ralf Westerhuis, Theo Wallimann, M. Rebecca Heiner-Fokkema, Stephan J. L. Bakker and Casper F. M. Franssen

    Citation: Journal of Translational Medicine 2021 19:115

    Content type: Research

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  26. The MBTPS2 gene on the X-chromosome encodes the membrane-bound transcription factor protease, site-2 (MBTPS2) or site-2 protease (S2P) which cleaves and activates several signaling and regulatory proteins from th...

    Authors: Natarin Caengprasath, Thanakorn Theerapanon, Thantrira Porntaveetus and Vorasuk Shotelersuk

    Citation: Journal of Translational Medicine 2021 19:114

    Content type: Review

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  27. Bladder cancer (BCa) is a common malignancy characterized by high heterogeneity, yet the current treatment modalities are limited. The aim of the present investigation was to unravel the functional role of Kar...

    Authors: Fanchang Zeng, Liumei Luo, Daoyuan Li, Juncheng Guo and Min Guo

    Citation: Journal of Translational Medicine 2021 19:112

    Content type: Research

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  28. Ovarian cancer (OV) is the deadliest gynecological cancer. Transmembrane protein 119 (TMEM119) has been reported as oncogene in several human cancers. However, the function of TMEM119 in OV is still poorly known.

    Authors: Tianshui Sun, Fangfang Bi, Zhuonan Liu and Qing Yang

    Citation: Journal of Translational Medicine 2021 19:111

    Content type: Research

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  29. The incidence of breast cancer (BC) and/or ovarian cancer (OC) is increasing in Tunisia especially in young women and mostly those with family history. However, the spectrum of BRCA mutations remains little explo...

    Authors: Dorra Ben Ayed-Guerfali, Wala Ben Kridis-Rejab, Nihel Ammous-Boukhris, Wajdi Ayadi, Slim Charfi, Afef Khanfir, Tahia Sellami-Boudawara, Mounir Frikha, Jamel Daoud and Raja Mokdad-Gargouri

    Citation: Journal of Translational Medicine 2021 19:108

    Content type: Research

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  30. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Lin Yuan, Leyuan Wang, Xizi Du, Ling Qin, Ming Yang, Kai Zhou, Mengping Wu, Yu Yang, Zhiyuan Zheng, Yang Xiang, Xiangping Qu, Huijun Liu, Xiaoqun Qin and Chi Liu

    Citation: Journal of Translational Medicine 2021 19:107

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2020 18:467

  31. The aim of the study was to systematically review relevant studies to evaluate the diagnostic value of urinary kidney injury molecule 1 (uKIM-1) for acute kidney injury (AKI) in adults.

    Authors: Jiwen Geng, Yuxuan Qiu, Zheng Qin and Baihai Su

    Citation: Journal of Translational Medicine 2021 19:105

    Content type: Review

    Published on:

  32. Extracellular vesicles (EVs), known as cell-derived membranous structures harboring a variety of biomolecules, have been widely used in liquid biopsy. Due to the complex biological composition of plasma, plasm...

    Authors: Yang Yang, Yaojie Wang, Sisi Wei, Chaoxi Zhou, Jiarui Yu, Guiying Wang, Wenxi Wang and Lianmei Zhao

    Citation: Journal of Translational Medicine 2021 19:104

    Content type: Research

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  33. Exosomes are nanoparticle sized (100 ± 50 nm) extracellular vesicles (ECVs) that play important roles in cell-to-cell communication. They do this by utilizing their natural ability to shuttle signaling molecul...

    Authors: Michael J. Gonzalez, Mercedes F. Kweh, Pier Mario Biava, Jose Olalde, Alondra P. Toro, Pascal J. Goldschmidt-Clermont and Ian A. White

    Citation: Journal of Translational Medicine 2021 19:103

    Content type: Review

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  34. Non-alcoholic steatohepatitis (NASH) is a key stage in leading development of non-alcoholic simple fatty liver (NAFL) into cirrhosis and even liver cancer. This study aimed at exploring the lncRNAs expression ...

    Authors: Liangying Ye, Dan Zhao, Yangzhi Xu, Jiaen Lin, Jiahui Xu, Kunyuan Wang, Zhanhui Ye, Yufeng Luo, Shiming Liu and Hui Yang

    Citation: Journal of Translational Medicine 2021 19:101

    Content type: Research

    Published on:

  35. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Mathieu Blot, Jean-Baptiste Bour, Jean Pierre Quenot, Abderrahmane Bourredjem, Maxime Nguyen, Julien Guy, Serge Monier, Marjolaine Georges, Audrey Large, Auguste Dargent, Alexandre Guilhem, Suzanne Mouries-Martin, Jeremy Barben, Belaid Bouhemad, Pierre‑Emmanuel Charles, Pascal Chavanet…

    Citation: Journal of Translational Medicine 2021 19:100

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2020 18:457

  36. Glioma, the most common primary brain tumor, account Preparing figures for 30 to 40% of all intracranial tumors. Herein, we aimed to study the effects of M2 macrophage-derived exosomal microRNAs (miRNAs) on gl...

    Authors: Jie Yao, Zefen Wang, Yong Cheng, Chao Ma, Yahua Zhong, Yilei Xiao, Xu Gao and Zhiqiang Li

    Citation: Journal of Translational Medicine 2021 19:99

    Content type: Research

    Published on:

  37. The epigenetic abnormality of tumor-associated genes contributes to the pathogenesis of colorectal carcinoma (CRC). However, methylation in colorectal cancer is still poorly characterized.

    Authors: Hui Zhang, Chenxin Xu, Chen Shi, Junying Zhang, Ting Qian, Zhuo Wang, Rong Ma, Jianzhong Wu, Feng Jiang and Jifeng Feng

    Citation: Journal of Translational Medicine 2021 19:98

    Content type: Research

    Published on:

  38. Lipoprotein glomerulopathy (LPG) is a rare autosomal dominant kidney disease that is most commonly caused by mutations in ApoE Kyoto (p.R43C) and ApoE Sendai (p.R163P). Differences in phenotype among the vario...

    Authors: Hongyan Wu, Jing Yang, Yun-Qiang Liu, Song Lei, Mei Yang, Zhi Yang, Yuan Yang and Zhangxue Hu

    Citation: Journal of Translational Medicine 2021 19:97

    Content type: Research

    Published on:

  39. This study investigated whether maternal serum D-dimer (DD) alone or DD combined with alpha-fetoprotein (AFP) and free β-subunit of human chorionic gonadotropin (free β-hCG) in the second trimester could be us...

    Authors: Yiming Chen, Yijie Chen, Xue Wang, Xuelian Chu, Wenwen Ning, Linyuan Gu, Liyao Li, Zhen Xie and Caihe Wen

    Citation: Journal of Translational Medicine 2021 19:94

    Content type: Research

    Published on:

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