Articles

Low serum vitamin D concentration is correlated with anemia, microinflammation, and oxidative stress in patients with peritoneal dialysis

Peritoneal dialysis (PD) is a form of dialysis to replace the function of kidney, that uses the peritoneum as a dialysis membrane to remove metabolites and water retained in the body. Vitamin D deficiency is p...

Authors: Chi Zhang, Junsheng Wang, Xiaohui Xie and Dong Sun

Circadian rhythms affect bone reconstruction by regulating bone energy metabolism

Metabolism is one of the most complex cellular biochemical reactions, providing energy and substances for basic activities such as cell growth and proliferation. Early studies have shown that glucose is an imp...

Authors: Beibei Luo, Xin Zhou, Qingming Tang, Ying Yin, Guangxia Feng, Shue Li and Lili Chen

Wnt pathway-related three-mRNA clinical outcome signature in bladder urothelial carcinoma: computational biology and experimental analyses

The Wnt signaling pathway is core to the growth of bladder tumors. Epithelial-to-mesenchymal transition (EMT) is significant for bladder tumor metastasis. Nevertheless, the relationship between the Wnt signali...

Authors: Siqing Sun, Yutao Wang, Jianfeng Wang and Jianbin Bi

Nuclear HER3 expression improves the prognostic stratification of patients with HER1 positive advanced laryngeal squamous cell carcinoma

Compared to the other members of human epidermal growth factor family receptors (HER), the role of HER3 has not been well defined in laryngeal cancer. The predictive and prognostic role of HER3 has been the fo...

Authors: Giovanni Almadori, Antonella Coli, Eugenio De Corso, Dario Antonio Mele, Stefano Settimi, Giovanni Di Cintio, Francesca Brigato, Domenico Scannone, Thomas E. Carey, Gaetano Paludetti, Libero Lauriola and Franco Oreste Ranelletti

Correction to: YM155 decreases radiation-induced invasion and reverses epithelial–mesenchymal transition by targeting STAT3 in glioblastoma

Authors: Xin Zhang, Xuehai Wang, Ran Xu, Jianxiong Ji, Yangyang Xu, Mingzhi Han, Yuzhen Wei, Bin Huang, Anjing Chen, Qing Zhang, Wenjie Li, Jian Wang, Xingang Li and Chen Qiu

Feasibility and utility of MRI and dynamic ¹⁸F-FDG-PET in an orthotopic organoid-based patient-derived mouse model of endometrial cancer

Pelvic magnetic resonance imaging (MRI) and whole-body positron emission tomography-computed tomography (PET-CT) play an important role at primary diagnostic work-up and in detecting recurrent disease in endom...

Authors: Heidi Espedal, Hege F. Berg, Tina Fonnes, Kristine E. Fasmer, Camilla Krakstad and Ingfrid S. Haldorsen

Role of galectin 3 binding protein in cancer progression: a potential novel therapeutic target

The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted, hyperglycosylated protein expressed by the majority of human cells. It was first identified as cancer and metastasis associate...

Authors: Emily Capone, Stefano Iacobelli and Gianluca Sala

Gene clusters based on OLIG2 and CD276 could distinguish molecular profiling in glioblastoma

The molecular profiling of glioblastoma (GBM) based on transcriptomic analysis could provide precise treatment and prognosis. However, current subtyping (classic, mesenchymal, neural, proneural) is time-consum...

Authors: Minjie Fu, Jinsen Zhang, Weifeng Li, Shan He, Jingwen Zhang, Daniel Tennant, Wei Hua and Ying Mao

Cytometric analysis of patients with COVID-19: what is changed in the second wave?

Coronavirus disease 2019 (COVID-19) pandemic had a 1st wave in Europe from March to May 2020 and a 2nd wave since September 2020. We previously studied 35 hospitalized COVID-19 patients of the 1st wave demonst...

Authors: Giulia Scalia, Maddalena Raia, Monica Gelzo, Sara Cacciapuoti, Annunziata De Rosa, Biagio Pinchera, Riccardo Scotto, Agnese Giaccone, Mauro Mormile, Gabriella Fabbrocini, Ivan Gentile, Roberto Parrella and Giuseppe Castaldo

Correction to: Serum IFN-γ levels predict the therapeutic effect of mesenchymal stem cell transplantation in active rheumatoid arthritis

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yi Yang, Xiao He, Rongseng Zhao, Wei Guo, Ming Zhu, Wei Xing, Dongpo Jiang, Chongyang Liu and Xiang Xu

FGFR2 alteration as a potential therapeutic target in poorly cohesive gastric carcinoma

Poorly cohesive (PC) is a unique histologic subtype of gastric cancer (GC), with an increasing incidence in recent years. However, the molecular characteristics and therapeutic targets of PC GC are not yet wel...

Authors: Yue Wang, Tao Shi, Xuan Wang, Jinwei Hu, Lixia Yu, Qin Liu, Nandie Wu, Baorui Liu and Jia Wei

Long non-coding RNA NORAD promotes pancreatic cancer stem cell proliferation and self-renewal by blocking microRNA-202-5p-mediated ANP32E inhibition

Cancer stem cells (CSCs) are key regulators in the processes of tumor initiation, progression, and recurrence. The mechanism that maintains their stemness remains enigmatic, although the role of several long n...

Authors: Yu-Shui Ma, Xiao-Li Yang, Yu-Shan Liu, Hua Ding, Jian-Jun Wu, Yi Shi, Cheng-You Jia, Gai-Xia Lu, Dan-Dan Zhang, Hui-Min Wang, Pei-Yao Wang, Fei Yu, Zhong-Wei Lv, Gao-Ren Wang, Ji-Bin Liu and Da Fu

Low CCL19 expression is associated with adverse clinical outcomes for follicular lymphoma patients treated with chemoimmunotherapy

This study aimed to recognize the hub genes associated with prognosis in follicular lymphoma (FL) treated with first-line rituximab combined with chemotherapy.

Authors: Yu Zhou, Shasha Wang, Yunxia Tao, Haizhu Chen, Yan Qin, Xiaohui He, Shengyu Zhou, Peng Liu, Jianliang Yang, Sheng Yang, Lin Gui, Ning Lou, Zhishang Zhang, Jiarui Yao, Xiaohong Han and Yuankai Shi

A novel immune subtype classification of ER-positive, PR-negative and HER2-negative breast cancer based on the genomic and transcriptomic landscape

The diversity and plasticity behind ER+/PR−/HER2− breast cancer have not been widely explored. It is essential to identify heterogeneous microenvironment phenotypes and investigate specific genomic events driv...

Authors: Peiling Xie, Rui An, Shibo Yu, Jianjun He and Huimin Zhang

Vaso-occlusive crisis in sickle cell disease: a vicious cycle of secondary events

Painful vaso-occlusive crisis (VOC) remains the most common reason for presenting to the Emergency Department and hospitalization in patients with sickle cell disease (SCD). Although two new agents have been a...

Authors: Tim Jang, Maria Poplawska, Emanuela Cimpeanu, George Mo, Dibyendu Dutta and Seah H. Lim

CYT387, a potent IKBKE inhibitor, suppresses human glioblastoma progression by activating the Hippo pathway

Recent studies have showed that IKBKE is overexpressed in several kinds of cancers and that IKBKE-knockdown inhibits tumor progression. In this article, we first verified that two glioblastoma cell lines, U87-...

Authors: Xin Wang, Jie Lu, Jing Li, Yang Liu, Gaochao Guo and Qiang Huang

A new Mfn-2 related synthetic peptide promotes vascular smooth muscle cell apoptosis via regulating the mitochondrial apoptotic pathway by inhibiting Akt signaling

Restenosis after angioplasty is a major challenge for the treatment of coronary artery diseases. Facilitation of vascular smooth muscle cell (VSMC) apoptosis may be an attractive approach to decrease the incid...

Authors: Xinxin Zhang, Xiangyu Xu, Li Lu, Xiaoning Wan, Yating Qin, Weibin Ruan, Chao Lv, Lin He and Xiaomei Guo

Longitudinal analysis of symptom-based clustering in patients with primary Sjogren’s syndrome: a prospective cohort study with a 5-year follow-up period

Sjogren’s syndrome (SS) is a heterogenous disease with various phenotypes. We aimed to provide a relevant subclassification based on symptom-based clustering for patients with primary (p) SS.

Authors: Jennifer Jooha Lee, Young Jae Park, Misun Park, Hyeon Woo Yim, Sung Hwan Park and Seung-Ki Kwok

Identification of circulating sphingosine kinase-related metabolites for prediction of type 2 diabetes

Sphingosine Kinase (SphK) that catalyzes sphingosine (Sph) to sphingosine 1-phosphate (S1P), plays a key role in both sphingolipid metabolism and cellular signaling. While SphK has been implicated in type 2 di...

Authors: Qi Chen, Wei Wang, Ming-Feng Xia, You-li Lu, Hua Bian, Chen Yu, Xiao-Ying Li, Mathew A. Vadas, Xin Gao, Huan-Dong Lin and Pu Xia

IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis

Patients with rheumatoid arthritis (RA) have increased levels of interleukin-18 (IL-18) and decreased levels of IL-18 binding protein (IL-18BP) in the serum and synovial fluid (SF) compared to those in patient...

Authors: Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee and Hae-Rim Kim

Comprehensive analysis of EMT-related genes and lncRNAs in the prognosis, immunity, and drug treatment of colorectal cancer

EMT is an important biological process in the mechanism of tumor invasion and metastasis. However, there are still many unknowns about the specific mechanism of EMT in tumor. At present, a comprehensive analys...

Authors: Yang Yang, Mingyang Feng, LiangLiang Bai, Weiting Liao, Kexun Zhou, Mengxi Zhang, Qiuji Wu, Feng Wen, Wanting Lei, Pengfei Zhang, Nan Zhang, Jiaxing Huang and Qiu Li

Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis

Lung adenocarcinoma (LUAD) is a common subtype of lung cancer with high recurrence rate and fatality. Circ_0001361 has been recognized as key regulators in various malignancies, but its roles in LUAD remain am...

Authors: Hong-Yu Shen, Liu-Xi Shi, Lin Wang, Le-Ping Fang, Wei Xu, Ju-Qing Xu, Bo-Qiang Fan and Wei-Fei Fan

Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients

Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with a median age of 68 in clinical diagnosis. About 60% patients are over 60 years old. There are various treatment options for AML pa...

Authors: Jizhang Bao, Xinhua Zhao, Jiahui Lu, Zhaoyang Hu, Minghui Hu, Xiaoxia Hu, Libing Wang, Qi Hu, Weiling Sun, Jie Wang, Hailin Chen, Hao Lu, Changgui Li, Jing Xu, Yongming Zhou and Wenwei Zhu

A direct negative feedback loop of miR-4721/FOXA1/Nanog promotes nasopharyngeal cell stem cell enrichment and metastasis

The recurrence and metastasis of nasopharyngeal cancer (NPC) may be mainly attributed to the persistence of cancer stem cells (CSCs); however, the linkage mechanism has yet to be fully elucidated.

Authors: Mengyang Zhao, Zibo Tang, Yijun Wang, Jiaojiao Ding, Ying Guo and Tianhui Gao

microRNA-193-3p attenuates myocardial injury of mice with sepsis via STAT3/HMGB1 axis

Little is known regarding the functional role of microRNA-193-3p (miR-193-3p) in sepsis. Hence, the aim of the present study was to investigate the effect of miR-193-3p on myocardial injury in mice with sepsis...

Authors: Jianyuan Pan, Buse Alexan, Dorn Dennis, Chiristine Bettina, Laeuf Ilona Mariya Christoph and Yongqin Tang

Loss of heterozygosity related to TMB and TNB may predict PFS for patients with SCLC received the first line setting

Authors: Chenyue Zhang, Kai Wang and Haiyong Wang

Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases

Tumor heterogeneity is a primary cause of treatment failure. However, changes in drug sensitivity over time are not well mapped in cancer. Patient-derived organoids (PDOs) may predict clinical drug responses e...

Authors: Kushtrim Kryeziu, Seyed H. Moosavi, Christian H. Bergsland, Marianne G. Guren, Peter W. Eide, Max Z. Totland, Kristoffer Lassen, Andreas Abildgaard, Arild Nesbakken, Anita Sveen and Ragnhild A. Lothe

Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway

Antiangiogenic therapy has increasingly become an important strategy for the treatment of colorectal cancer. Recent studies have shown that the tumour microenvironment (TME) promotes tumour angiogenesis. Bufal...

Authors: Kai Fang, Yueping Zhan, Ruiqiu Zhu, Yuqian Wang, Chengqi Wu, Min Sun, Yanyan Qiu, Zeting Yuan, Xin Liang, Peihao Yin and Ke Xu

Establishment of a novel glycolysis-related prognostic gene signature for ovarian cancer and its relationships with immune infiltration of the tumor microenvironment

Glycolysis affects tumor growth, invasion, chemotherapy resistance, and the tumor microenvironment. In this study, we aimed to construct a glycolysis-related prognostic model for ovarian cancer and analyze its...

Authors: Jianlei Bi, Fangfang Bi, Xue Pan and Qing Yang

Single-cell analysis of a tumor-derived exosome signature correlates with prognosis and immunotherapy response

Tumor-derived exosomes (TEXs) are involved in tumor progression and the immune modulation process and mediate intercellular communication in the tumor microenvironment. Although exosomes are considered promisi...

Authors: Jiani Wu, Dongqiang Zeng, Shimeng Zhi, Zilan Ye, Wenjun Qiu, Na Huang, Li Sun, Chunlin Wang, Zhenzhen Wu, Jianping Bin, Yulin Liao, Min Shi and Wangjun Liao

Evaluating predictive factors for toxicities experienced by head & neck cancer patients undergoing radiotherapy

The purpose of this study was to evaluate if HPV status serves as an independent predictor of early and late dysphagia outcomes when considered alongside standard patient characteristics and dose metrics for h...

Authors: Xenia Ray, Whitney Sumner, Leisa Sutton, Parag Sanghvi, Ida Deichaite and Vitali Moiseenko

Interferon regulatory factor family influences tumor immunity and prognosis of patients with colorectal cancer

Since interferon regulatory factor (IRF) family functions in immune response to viral infection, its role in colorectal cancer (CRC) has not been inspected before. This study tries to investigate members of IR...

Authors: Yan-Jie Chen, Shu-Neng Luo, Ling Dong, Tao-Tao Liu, Xi-Zhong Shen, Ning-Ping Zhang and Li Liang

Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study

Neuroinflammation has been proved to play a role in dopaminergic neuronal death in Parkinson’s disease (PD). This link highlights the relevance of the immune response in the progression of the disease. However...

Authors: Diana D. Álvarez-Luquín, Adrián Guevara-Salinas, Asiel Arce-Sillas, Raquel Espinosa-Cárdenas, Jaquelín Leyva-Hernández, Esteban U. Montes-Moratilla and Laura Adalid-Peralta

Multi-parametric MRI phenotype with trustworthy machine learning for differentiating CNS demyelinating diseases

Misdiagnosis of multiple sclerosis (MS) and neuromyelitis optica (NMO) may delay the treatment, resulting in poor prognosis. However, the precise identification of these two diseases is still challenging in cl...

Authors: Jing Huang, Bowen Xin, Xiuying Wang, Zhigang Qi, Huiqing Dong, Kuncheng Li, Yun Zhou and Jie Lu

Role of rehabilitation amidst the COVID-19 pandemic: a review

COVID-19 remains globally a highly infectious disease targeting multiple organs. Rehabilitation is increasingly valued among the supportive care fields to combat COVID-19 as currently definitive curative treat...

Authors: Chaoran Yu and Ernest Johann Helwig

TFH cells in systemic sclerosis

Systemic sclerosis is an autoimmune disease characterized by excessive dermal fibrosis with progression to internal organs, vascular impairment and immune dysregulation evidenced by the infiltration of inflamm...

Authors: Pauline Beurier, Laure Ricard, Deborah Eshagh, Florent Malard, Lama Siblany, Olivier Fain, Mohamad Mohty, Béatrice Gaugler and Arsène Mekinian

UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma

Ubiquitin-conjugating enzyme E2T (UBE2T) acts as an oncogene in various types of cancer. However, the mechanisms behind its oncogenic role remain unclear in lung cancer. This study aims to explore the function...

Authors: Jinhong Zhu, Haijiao Ao, Mingdong Liu, Kui Cao and Jianqun Ma

GSK2126458 has the potential to inhibit the proliferation of pancreatic cancer uncovered by bioinformatics analysis and pharmacological experiments

Pancreatic cancer is one of the most serious digestive malignancies. At present, there is an extreme lack of effective strategies in clinical treatment. The purpose of this study is to identify key genes and p...

Authors: Yueqin Feng, Yuguan Jiang and Fengjin Hao

Identification of prognostic values defined by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients

Epidermal growth factor receptor (EGFR) and lanthionine synthetase C-like 2 (LanCL2) genes locate in the same amplicon, and co-amplification of EGFR and LANCL2 is frequent in glioblastoma. However, the prognostic...

Authors: Hua-fu Zhao, Xiu-ming Zhou, Jing Wang, Fan-fan Chen, Chang-peng Wu, Peng-yu Diao, Lin-rong Cai, Lei Chen, Yan-wen Xu, Jing Liu, Zong-yang Li, Wen-lan Liu, Zhong-ping Chen, Guo-dong Huang and Wei-ping Li

Associations of immune cell homing gene signatures and infiltrates of lymphocyte subsets in human melanomas: discordance with CD163⁺ myeloid cell infiltrates

Immune cells in the tumor microenvironment have prognostic value. In preclinical models, recruitment and infiltration of these cells depends on immune cell homing (ICH) genes such as chemokines, cell adhesion ...

Authors: Minyoung Kwak, Gulsun Erdag, Katie M. Leick, Stefan Bekiranov, Victor H. Engelhard and Craig L. Slingluff

Sex-specific plasma lipid profiles of ME/CFS patients and their association with pain, fatigue, and cognitive symptoms

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex illness which disproportionally affects females. This illness is associated with immune and metabolic perturbations that may be influenc...

Authors: Aurore Nkiliza, Megan Parks, Adam Cseresznye, Sarah Oberlin, James E. Evans, Teresa Darcey, Kristina Aenlle, Daniel Niedospial, Michael Mullan, Fiona Crawford, Nancy Klimas and Laila Abdullah

Applying low coverage whole genome sequencing to detect malignant ovarian mass

To evaluate whether low coverage whole genome sequencing is suitable for the detection of malignant pelvic mass and compare its diagnostic value with traditional tumor markers. We enrolled 63 patients with a p...

Authors: Ming Chen, Pengqiang Zhong, Mengzhi Hong, Jinfeng Tan, Xuegao Yu, Hao Huang, Juan Ouyang, Xiaoping Lin and Peisong Chen

Transcriptomic analysis of tumor tissues and organoids reveals the crucial genes regulating the proliferation of lung adenocarcinoma

Accumulative evidence shows that an organoid is a more practical and reliable tool in cancer biology research. This study aimed to identify and validate crucial genes involved in non-small cell lung cancer car...

Authors: Xiao Ma, Su Yang, Hesheng Jiang, Yujie Wang and Zhen Xiang

SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

Solute carrier family 7 member 11(SLC7A11) is a component of cysteine/glutamate transporter, which plays a key role in tumor growth; however, its underlying effect on radiosensitivity in esophageal squamous ce...

Authors: Lei Feng, Kaikai Zhao, Liangchao Sun, Xiaoyang Yin, Junpeng Zhang, Conghe Liu and Baosheng Li

Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population

The causes of gestational diabetes mellitus (GDM) are still unclear. Recent studies have found that the imbalance of the gut microbiome could lead to disorders of human metabolism and immune system, resulting ...

Authors: Yao Su, Hong-Kun Wang, Xu-Pei Gan, Li Chen, Yan-Nan Cao, De-Cui Cheng, Dong-Yao Zhang, Wen-Yu Liu, Fei-Fei Li and Xian-Ming Xu

Convalescent plasma is of limited clinical benefit in critically ill patients with coronavirus disease-2019: a cohort study

Recently, convalescent plasma (CP) transfusion was employed for severe or critically ill patients with coronavirus disease-2019. However, the benefits of CP for patients with different conditions are still in ...

Authors: Li Huang, Che Zhang, Xihui Zhou, Zhou Zhao, Weiping Wang, Weidong Leng, Xiao Su and Qizhou Lian

Expression profiles and functional prediction of long non-coding RNAs LINC01133, ZEB1-AS1 and ABHD11-AS1 in the luminal subtype of breast cancer

Luminal breast cancer (BC) is the most frequent subtype accounting for more than 70% of BC. LncRNAs, a class of non-coding RNAs with more than 200 nucleotides, are involved in a variety of cellular processes a...

Authors: Sepideh Mehrpour Layeghi, Maedeh Arabpour, Abbas Shakoori, Mohammad Mehdi Naghizadeh, Yaser Mansoori, Javad Tavakkoly Bazzaz and Rezvan Esmaeili

What can the neurological manifestations of COVID-19 tell us: a meta-analysis

Covid-19 became a global pandemic in 2019. Studies have shown that coronavirus can cause neurological symptoms, but clinical studies on its neurological symptoms are limited. In this meta-analysis, we aimed to...

Authors: Yuanyuan He, Xiaojie Bai, Tiantian Zhu, Jialin Huang and Hong Zhang

Integrated analysis of competing endogenous RNA networks in peripheral blood mononuclear cells of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease with a complicated pathogenesis, and its aetiology has not been clearly unveiled. The lack of effective diagnosis and treatment methods makes it nece...

Authors: Wencong Song, Jie Qiu, Lianghong Yin, Xiaoping Hong, Weier Dai, Donge Tang, Dongzhou Liu and Yong Dai

Integrative analysis and experiments to explore angiogenesis regulators correlated with poor prognosis, immune infiltration and cancer progression in lung adenocarcinoma

Angiogenesis is the process of capillary sprouting from pre-existing vessels and it plays a critical role in the carcinogenic process of lung adenocarcinoma (LUAD). However, the association of angiogenesis reg...

Authors: Songhua Cai, Xiaotong Guo, Chujian Huang, Youjun Deng, Longde Du, Wenyi Liu, Chenglin Yang, Hongbo Zhao, Kai Ma, Lixu Wang, Jie He and Zhentao Yu