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  1. Research

    Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics

    Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor protein that functions as a potential tumor suppressor, and SPOP mutations have been identified in ~10% of human prostate cancers. However, it ...

    Hui Wang, Christopher E. Barbieri, Jintang He, Yuqian Gao, Tujin Shi, Chaochao Wu, Athena A. Schepmoes, Thomas L. Fillmore, Sung-Suk Chae, Dennis Huang, Juan Miguel Mosquera, Wei-Jun Qian, Richard D. Smith, Sudhir Srivastava, Jacob Kagan, David G. Camp II…

    Journal of Translational Medicine 2017 15:175

    Published on: 15 August 2017

  2. Research

    Role of IQGAP3 in metastasis and epithelial–mesenchymal transition in human hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide owing to its high rates of metastasis and recurrence. The oncogene IQ motif-containing GTPase activating protein 3 (IQGAP3) is ubiquitous...

    Yongjie Shi, Nan Qin, Qiang Zhou, Yanqiu Chen, Sicong Huang, Bo Chen, Gang Shen and Hongyun Jia

    Journal of Translational Medicine 2017 15:176

    Published on: 15 August 2017

  3. Research

    Erythrocyte depletion from bone marrow: performance evaluation after 50 clinical-scale depletions with Spectra Optia BMC

    Red blood cell (RBC) depletion is a standard graft manipulation technique for ABO-incompatible bone marrow (BM) transplants. The BM processing module for Spectra Optia, “BMC”, was previously introduced. We her...

    Soo-Zin Kim-Wanner, Gesine Bug, Juliane Steinmann, Salem Ajib, Nadine Sorg, Carolin Poppe, Milica Bunos, Eva Wingenfeld, Christiane Hümmer, Beate Luxembourg, Erhard Seifried and Halvard Bonig

    Journal of Translational Medicine 2017 15:174

    Published on: 11 August 2017

  4. Research

    Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma

    It is now recognized that asthma can present in different forms. Typically, asthma present with symptoms of wheeze, breathlessness and cough. Atypical forms of asthma such as cough variant asthma (CVA) or che...

    Chao Cao, Wen Li, Wen Hua, Fugui Yan, Hao Zhang, Huaqiong Huang, Yinghua Ying, Na Li, Fen Lan, Shaobin Wang, Xiao Chen, Jing Li, Jinkai Liu, Tianwen Lai, Zhengqiang Bao, Yuan Cao…

    Journal of Translational Medicine 2017 15:171

    Published on: 4 August 2017

  5. Research

    Tough decoy targeting of predominant let-7 miRNA species in adult human hematopoietic cells

    In humans, the heterochronic cascade composed of the RNA-binding protein LIN28 and its major target, the let-7 family of microRNAs (miRNAs), is highly regulated during human erythroid ontogeny. Additionally, down...

    Jaira F. de Vasconcellos, Colleen Byrnes, Y. Terry Lee, Joshua M. Allwardt, Megha Kaushal, Antoinette Rabel and Jeffery L. Miller

    Journal of Translational Medicine 2017 15:169

    Published on: 2 August 2017

  6. Research

    Survival impact of pre-treatment neutrophils on oropharyngeal and laryngeal cancer patients undergoing definitive radiotherapy

    Squamous cell carcinoma of the head and neck (HNSCC) represents an array of disease processes with a generally unfavorable prognosis. Inflammation plays an important role in tumor development and response to t...

    Whitney A. Sumner, William A. Stokes, Ayman Oweida, Kiersten L. Berggren, Jessica D. McDermott, David Raben, Diana Abbott, Bernard Jones, Gregory Gan and Sana D. Karam

    Journal of Translational Medicine 2017 15:168

    Published on: 2 August 2017

  7. Research

    Comparative analysis of the EGFR, HER2, c-MYC, and MET variations in colorectal cancer determined by three different measures: gene copy number gain, amplification status and the 2013 ASCO/CAP guideline criterion for HER2 testing of breast cancer

    The purpose of this study was to explore gene copy number (GCN) variation of EGFR, HER2, c-MYC, and MET in patients with primary colorectal cancer (CRC).

    Yoonjin Kwak, Sumi Yun, Soo Kyung Nam, An Na Seo, Kyu Sang Lee, Eun Shin, Heung-Kwon Oh, Duck Woo Kim, Sung Bum Kang, Woo Ho Kim and Hye Seung Lee

    Journal of Translational Medicine 2017 15:167

    Published on: 1 August 2017

  8. Research

    Coiled-coil domain containing 109B is a HIF1α-regulated gene critical for progression of human gliomas

    The coiled-coil domain is a structural motif found in proteins that participate in a variety of biological processes. Aberrant expression of such proteins has been shown to be associated with the malignant beh...

    Ran Xu, Mingzhi Han, Yangyang Xu, Xin Zhang, Chao Zhang, Di Zhang, Jianxiong Ji, Yuzhen Wei, Shuai Wang, Bin Huang, Anjing Chen, Qing Zhang, Wenjie Li, Tao Sun, Feng Wang, Xingang Li…

    Journal of Translational Medicine 2017 15:165

    Published on: 28 July 2017

  9. Review

    The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE

    Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a common and severe disease with a considerable social and economic impact. So far, the etiology is not known, and neither a diagnostic marker ...

    Carmen Scheibenbogen, Helma Freitag, Julià Blanco, Enrica Capelli, Eliana Lacerda, Jerome Authier, Mira Meeus, Jesus Castro Marrero, Zaiga Nora-Krukle, Elisa Oltra, Elin Bolle Strand, Evelina Shikova, Slobodan Sekulic and Modra Murovska

    Journal of Translational Medicine 2017 15:162

    Published on: 26 July 2017

  10. Research

    Mesenchymal stem cells from sternum: the type of heart disease, ischemic or valvular, does not influence the cell culture establishment and growth kinetics

    In an attempt to increase the therapeutic potential for myocardial regeneration, there is a quest for new cell sources and types for cell therapy protocols. The pathophysiology of heart diseases may affect cel...

    Lucinara Dadda Dias, Karina Rabello Casali, Carine Ghem, Melissa Kristocheck da Silva, Grasiele Sausen, Patrícia Bonini Palma, Dimas Tadeu Covas, Renato A. K. Kalil, Beatriz D. Schaan, Nance Beyer Nardi and Melissa Medeiros Markoski

    Journal of Translational Medicine 2017 15:161

    Published on: 25 July 2017

  11. Research

    Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability

    Changes in glucose and energy metabolism contribute to the altered phenotype of cancer cells and are the basis for positron emission tomography with 18F-fluoro-2-deoxy-d-glucose (FDG) to visualize tumors in vivo....

    Martina Broecker-Preuss, Nina Becher-Boveleth, Andreas Bockisch, Ulrich Dührsen and Stefan Müller

    Journal of Translational Medicine 2017 15:158

    Published on: 19 July 2017

  12. Research

    High expression of ETS2 predicts poor prognosis in acute myeloid leukemia and may guide treatment decisions

    ETS2 is a downstream effector of the RAS/RAF/ERK pathway, which plays a critical role in the development of malignant tumor. However, the clinical impact of ETS2 expression in AML rema...

    Lin Fu, Huaping Fu, Qingyun Wu, Yifan Pang, Keman Xu, Lei Zhou, Jianlin Qiao, Xiaoyan Ke, Kailin Xu and Jinlong Shi

    Journal of Translational Medicine 2017 15:159

    Published on: 19 July 2017

  13. Research

    Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure

    MicroRNAs (miRNAs) are a class of regulatory RNAs that regulate gene expression post-transcriptionally. Little, however, is known on the expression profile of circulating miRNAs in Tetralogy of Fallot (TOF) pa...

    Masood Abu-Halima, Eckart Meese, Andreas Keller, Hashim Abdul-Khaliq and Tanja Rädle-Hurst

    Journal of Translational Medicine 2017 15:156

    Published on: 10 July 2017

  14. Research

    Impaired B cell immunity in acute myeloid leukemia patients after chemotherapy

    Changes in adaptive immune cells after chemotherapy in adult acute myeloid leukemia (AML) may have implications for the success of immunotherapy. This study was designed to determine the functional capacity of...

    Meghali Goswami, Gabrielle Prince, Angelique Biancotto, Susan Moir, Lela Kardava, Brian H. Santich, Foo Cheung, Yuri Kotliarov, Jinguo Chen, Rongye Shi, Huizhi Zhou, Hana Golding, Jody Manischewitz, Lisa King, Lauren M. Kunz, Kimberly Noonan…

    Journal of Translational Medicine 2017 15:155

    Published on: 10 July 2017

  15. Research

    The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype

    Dendritic cells (DC) and tumour-associated macrophages (TAM) are essential in linking the innate and adaptive immune response against tumour cells and tumour progression. These cells are also potential target ...

    Sebastian Lundgren, Emelie Karnevi, Jacob Elebro, Björn Nodin, Mikael C. I. Karlsson, Jakob Eberhard, Karin Leandersson and Karin Jirström

    Journal of Translational Medicine 2017 15:152

    Published on: 3 July 2017

  16. Protocol

    Effect of a 6-month pedometer-based walking intervention on functional capacity in patients with chronic heart failure with reduced (HFrEF) and with preserved (HFpEF) ejection fraction: study protocol for two multicenter randomized controlled trials

    Regular physical activity is recommended for patients with chronic heart failure to improve their functional capacity, and walking is a popular, effective, and safe form of physical activity. Pedometers have s...

    Tomas Vetrovsky, Michal Siranec, Jiri Parenica, Martin Griva, Jiri Stastny, Jan Precek, Radek Pelouch, Vaclav Bunc, Ales Linhart and Jan Belohlavek

    Journal of Translational Medicine 2017 15:153

    Published on: 3 July 2017

  17. Review

    CSPG4: a prototype oncoantigen for translational immunotherapy studies

    Thanks to striking progress in both the understanding of anti-tumor immune response and the characterization of several tumor associated antigens (TAA), a more rational design and more sophisticated strategies...

    Valeria Rolih, Giuseppina Barutello, Selina Iussich, Raffaella De Maria, Elena Quaglino, Paolo Buracco, Federica Cavallo and Federica Riccardo

    Journal of Translational Medicine 2017 15:151

    Published on: 1 July 2017

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