Articles

Presence of a 34-gene signature is a favorable prognostic marker in squamous non-small cell lung carcinoma

The tumor immune microenvironment is a heterogeneous entity. Gene expression analysis allows us to perform comprehensive immunoprofiling and may assist in dissecting the different components of the immune infi...

Authors: W. S. M. E. Theelen, O. Krijgsman, K. Monkhorst, T. Kuilman, D. D. G. C. Peters, S. Cornelissen, M. A. Ligtenberg, S. M. Willems, J. L. G. Blaauwgeers, C. J. M. van Noesel, D. S. Peeper, M. M. van den Heuvel and K. Schulze

The timeline and risk factors of clinical progression of COVID-19 in Shenzhen, China

The novel coronavirus disease 2019 (COVID-19) broke out globally. Early prediction of the clinical progression was essential but still unclear. We aimed to evaluate the timeline of COVID-19 development and ana...

Authors: Fang Wang, Mengyuan Qu, Xuan Zhou, Kai Zhao, Changxiang Lai, Qiyuan Tang, Wenjie Xian, Ruikun Chen, Xuan Li, Zhiyu Li, Qing He and Lei Liu

ICON: a randomized phase IIb study evaluating immunogenic chemotherapy combined with ipilimumab and nivolumab in patients with metastatic hormone receptor positive breast cancer

Immunotherapy with checkpoint inhibitors (CPI) targeting PD-1 or CTLA-4 has emerged as an important treatment modality for several cancer forms. In hormone receptor positive breast cancer (HR + BC), this thera...

Authors: J. A. Kyte, N. K. Andresen, H. G. Russnes, S. Ø. Fretland, R. S. Falk, O. C. Lingjærde and B. Naume

Intensive care unit-acquired hyponatremia in critically ill medical patients

Previous research has focused on intensive care unit (ICU)-acquired hypernatremia; however, ICU-acquired hyponatremia has frequently been overlooked and has rarely been studied in surgical or mixed ICUs. The a...

Authors: Jae Kyeom Sim, Ryoung-Eun Ko, Soo Jin Na, Gee Young Suh and Kyeongman Jeon

External validation of the European risk assessment tool for chronic cardio-metabolic disorders in a Middle Eastern population

High burden of chronic cardio-metabolic disorders including type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD), and cardiovascular disease (CVD) have been reported in the Middle East and North Afric...

Authors: Samaneh Asgari, Fatemeh Moosaie, Davood Khalili, Fereidoun Azizi and Farzad Hadaegh

Comparable prevalence of distant metastasis and survival of different primary site for LN + pancreatic tumor

Few studies have delved into the prevalence of distant metastasis (DM +) and survival for patients with lymph node metastases (LN +) by primary site. We aimed to detect differences in distant metastasis and pr...

Authors: Xin Lou, Jun Li, Ya-Qing Wei, Zhi-Jia Jiang, Ming Chen and Jin-Jin Sun

Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT

NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity that results in therapeutic failure in pediatric acute lymphoblastic leukemia (ALL). However, many patients wi...

Authors: Yoomi Park, Hyery Kim, Heewon Seo, Jung Yoon Choi, Youngeun Ma, Sunmin Yun, Byung-Joo Min, Myung-Eui Seo, Keon Hee Yoo, Hyoung Jin Kang, Ho Joon Im and Ju Han Kim

The establishment of a rheumatoid arthritis primate model in Macaca fascicularis

Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their cl...

Authors: Hyun Sik Na, Seon-yeong Lee, Hong Ki Min, Wan-je Park, Jung-hwan Lee, Ka-hee Cho, Shin-hee Hong, Dae-hoon Kim, Jooyeon Jhun, Jeong-Won Choi, Sung-Min Kim, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park

Changes in heart morphometric parameters over the course of a monocrotaline-induced pulmonary arterial hypertension rat model

Aim of this study was to assess changes in cardiac morphometric parameters at different stages of pulmonary arterial hypertension (PAH) using a monocrotaline-induced rat model.

Authors: Mateusz K. Hołda, Elżbieta Szczepanek, Joanna Bielawska, Natalia Palka, Dorota Wojtysiak, Paulina Frączek, Michał Nowakowski, Natalia Sowińska, Zbigniew Arent, Piotr Podolec and Grzegorz Kopeć

Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection

Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansio...

Authors: Adam Brufsky, Juan Luis Gomez Marti, Azadeh Nasrazadani and Michael T. Lotze

Nutritional management of lactose intolerance: the importance of diet and food labelling

Worldwide, 70% of the adult population has limited expression of lactase enzyme with a wide variation among different regions and countries. Lactase deficiency may lead to lactose intolerance (LI). Depending b...

Authors: Maria Sole Facioni, Benedetta Raspini, Francesca Pivari, Elena Dogliotti and Hellas Cena

Comments on: Huang et al. (2019) Emerging trends and research foci in gastrointestinal microbiome’, J. Transl. Med., 17: 67

Authors: Yuh-Shan Ho

Correction to: Accumulation of blood-circulating PD-L1-expressing M-MDSCs and monocytes/macrophages in pretreatment ovarian cancer patients is associated with soluble PD-L1

An amendment to this paper has been published and can be accessed via the original article.

Authors: Karolina Okła, Alicja Rajtak, Arkadiusz Czerwonka, Marcin Bobiński, Anna Wawruszak, Rafał Tarkowski, Wiesława Bednarek, Justyna Szumiło and Jan Kotarski

Advanced bioinformatics rapidly identifies existing therapeutics for patients with coronavirus disease-2019 (COVID-19)

The recent global pandemic has placed a high priority on identifying drugs to prevent or lessen clinical infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused by Coronavirus disease...

Authors: Jason Kim, Jenny Zhang, Yoonjeong Cha, Sarah Kolitz, Jason Funt, Renan Escalante Chong, Scott Barrett, Rebecca Kusko, Ben Zeskind and Howard Kaufman

Evaluating blood–brain barrier permeability in a rat model of type 2 diabetes

This is an exploratory study using a novel imaging modality, quantitative ultrashort time-to-echo, contrast enhanced (QUTE-CE) magnetic resonance imaging to evaluate the permeability of the blood–brain barrier...

Authors: Ju Qiao, Christopher M. Lawson, Kilian F. G. Rentrup, Praveen Kulkarni and Craig F. Ferris

A fast, simple, and cost-effective method of expanding patient-derived xenograft mouse models of pancreatic ductal adenocarcinoma

Patient-derived xenograft (PDX) mouse models of cancer have been recognized as better mouse models that recapitulate the characteristics of original malignancies including preserved tumor heterogeneity, lineag...

Authors: Zhenyang Liu, Michael Ho-Young Ahn, Tomohiro Kurokawa, Amy Ly, Gong Zhang, Fuyou Wang, Teppei Yamada, Ananthan Sadagopan, Jane Cheng, Cristina R. Ferrone, Andrew S. Liss, Kim C. Honselmann, Gregory R. Wojtkiewicz, Soldano Ferrone and Xinhui Wang

WT1 facilitates the self-renewal of leukemia-initiating cells through the upregulation of BCL2L2: WT1-BCL2L2 axis as a new acute myeloid leukemia therapy target

Overexpression of Wilms’ tumor-1 (WT1) transcription factor facilitates proliferation in acute myeloid leukemia (AML). However, whether WT1 is enriched in the leukemia-initiating cells (LICs) and leukemia stem ce...

Authors: Bin Zhou, Xianghong Jin, Weiwei Jin, Xingzhou Huang, Yanfei Wu, Haiying Li, Weijian Zhu, Xiaoyi Qin, Haige Ye and Shenmeng Gao

“Right-to-Try” experimental drugs: an overview

The “Right-to-Try” experimental drugs act passed by Donald Trump in 2018 provides an opportunity of early access to experimental drugs for the treatment of life-threatening diseases and a potential boon to man...

Authors: Vijay Mahant

ALICE: a randomized placebo-controlled phase II study evaluating atezolizumab combined with immunogenic chemotherapy in patients with metastatic triple-negative breast cancer

Immunotherapy with checkpoint inhibitors (CI) represents an important novel development in cancer treatment. Metastatic triple-negative breast cancer (mTNBC) is incurable, with a median survival of only ~ 13 m...

Authors: J. A. Kyte, A. Røssevold, R. S. Falk and B. Naume

Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas

With the aim of providing a dynamic evaluation of the effects of basic environmental parameters on COVID-19-related death rate, we assessed the correlation between average monthly high temperatures and populat...

Authors: Francesca Benedetti, Maria Pachetti, Bruna Marini, Rudy Ippodrino, Robert C. Gallo, Massimo Ciccozzi and Davide Zella

MicroRNA-181a as novel liquid biopsy marker of central nervous system involvement in pediatric acute lymphoblastic leukemia

Refractory central nervous system (CNS) involvement is among the major causes of therapy failure in childhood acute leukemia. Applying contemporary diagnostic methods, CNS disease is often underdiagnosed. To e...

Authors: Bálint Egyed, Nóra Kutszegi, Judit C. Sági, András Gézsi, Andrea Rzepiel, Tamás Visnovitz, Péter Lőrincz, Judit Müller, Marianna Zombori, Csaba Szalai, Dániel J. Erdélyi, Gábor T. Kovács and Ágnes F. Semsei

Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications

Angiogenesis is a multistep process and various molecules are involved in regulating it. Extracellular vesicles are cell-derived particles, secreted from several types of cells and are known to mediate cell-to...

Authors: Mahdi Ahmadi and Jafar Rezaie

The unique association between the level of peripheral blood monocytes and the prevalence of diabetic retinopathy: a cross-sectional study

The attraction and influx of monocytes into the retina has been considered a critical step in the development of diabetic retinopathy (DR). However, large population studies about the association between perip...

Authors: Heng Wan, Yan Cai, Yuying Wang, Sijie Fang, Chi Chen, Yi Chen, Fangzhen Xia, Ningjian Wang, Minghao Guo and Yingli Lu

Involvement of glutathione peroxidases in the occurrence and development of breast cancers

Glutathione peroxidases (GPxs) belong to a family of enzymes that is important in organisms; these enzymes promote hydrogen peroxide metabolism and protect cell membrane structure and function from oxidative d...

Authors: Man-Li Zhang, Hua-Tao Wu, Wen-Jia Chen, Ya Xu, Qian-Qian Ye, Jia-Xin Shen and Jing Liu

Epidemiological and clinical factors associated with post-exertional malaise severity in patients with myalgic encephalomyelitis/chronic fatigue syndrome

Post-exertional malaise (PEM), the cardinal feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), occurs generally after exposure to a stressor. It is characterized by the worsening of ME/CFS...

Authors: Alaa Ghali, Paul Richa, Carole Lacout, Aline Gury, Anne-Berengere Beucher, Chadi Homedan, Christian Lavigne and Geoffrey Urbanski

Overview of distinct 5-methylcytosine profiles of messenger RNA in human hepatocellular carcinoma and paired adjacent non-tumor tissues

Post-transcriptional methylation modifications, including 5-methylcytosine (m5C) modification, are closely related to the tumorigenesis of cancers. However, the mRNA profile of m5C modification in hepatocellul...

Authors: Qiyao Zhang, Qingyuan Zheng, Xiao Yu, Yuting He and Wenzhi Guo

Duplications involving the long range HMX1 enhancer are associated with human isolated bilateral concha-type microtia

Microtia is a congenital anomaly of ear that ranges in severity from mild structural abnormalities to complete absence of the outer ears. Concha-type microtia is considered to be a mild form. The H6 family hom...

Authors: Nuo Si, Xiaolu Meng, Xiaosheng Lu, Zhe Liu, Zhan Qi, Lianqing Wang, Chuan Li, Meirong Yang, Ye Zhang, Changchen Wang, Peipei Guo, Lingdong Zhu, Lei Liu, Zhengyong Li, Zhenyu Zhang, Zhen Cai…

Clinical significance of circulating tumor cells and metabolic signatures in lung cancer after surgical removal

Lung cancer (LC) remains the deadliest form of cancer globally. While surgery remains the optimal treatment strategy for individuals with early-stage LC, what the metabolic consequences are of such surgical in...

Authors: Dawei Yang, Xiaofang Yang, Yang Li, Peige Zhao, Rao Fu, Tianying Ren, Ping Hu, Yaping Wu, Hongjun Yang and Na Guo

Evaluation of T-activated proteins as recall antigens to monitor Epstein–Barr virus and human cytomegalovirus-specific T cells in a clinical trial setting

Pools of overlapping synthetic peptides are routinely used for ex vivo monitoring of antigen-specific T-cell responses. However, it is rather unlikely that these peptides match those resulting from naturally p...

Authors: Nina Körber, Uta Behrends, Ulrike Protzer and Tanja Bauer

Mesenchymal stem cells activate Notch signaling to induce regulatory dendritic cells in LPS-induced acute lung injury

Mesenchymal stem cells (MSCs) have been shown to alleviate acute lung injury (ALI) and induce the production of regulatory dendritic cells (DCregs), but the potential link between these two cell types remains ...

Authors: Zhonghua Lu, Shanshan Meng, Wei Chang, Shanwen Fan, Jianfeng Xie, Fengmei Guo, Yi Yang, Haibo Qiu and Ling Liu

Estrogen receptor α as a predictive biomarker for survival in human papillomavirus-positive oropharyngeal squamous cell carcinoma

Although oropharyngeal squamous cell carcinoma (OPSCC) with human papillomavirus (HPV) infection has a good prognosis, the accurate prediction of survival and risk of treatment failure is essential to design d...

Authors: Soohyeon Kwon, Soon-Hyun Ahn, Woo-Jin Jeong, Young Ho Jung, Yun Jung Bae, Jin Ho Paik, Jin-Haeng Chung and Hyojin Kim

Comparable endocrine and neuromuscular adaptations to variable vs. constant gravity-dependent resistance training among young women

Variable resistance has been shown to induce greater total work and muscle activation when compared to constant resistance. However, little is known regarding the effects of chronic exposure to variable resist...

Authors: Hamid Arazi, Lida Salek, Elham Nikfal, Mani Izadi, James J. Tufano, Bradley T. Elliott and Matt Brughelli

White-coat hypertension and incident end-stage renal disease in patients with non-dialysis chronic kidney disease: results from the C-STRIDE Study

Controversy remains whether white coat hypertension (WCH) is associated with renal prognosis in patients with chronic kidney disease (CKD).

Authors: Qin Wang, Yu Wang, Jinwei Wang, Luxia Zhang and Ming-hui Zhao

Development and validation of a prognostic model of resectable small-cell lung cancer: a large population-based cohort study and external validation

Survival outcomes of patients with resected SCLC differ widely. The aim of our study was to build a model for individualized risk assessment and accurate prediction of overall survival (OS) in resectable SCLC ...

Authors: Yu Wang, Zhaofei Pang, Xiaowei Chen, Tao Yan, Jichang Liu and Jiajun Du

Human induced pluripotent stem cell line banking for the production of rare blood type erythrocytes

The in vitro production of mature human red blood cells (RBCs) from induced pluripotent stem cells (iPSCs) has been the focus of research to meet the high demand for blood transfusions. However, limitations li...

Authors: Yu Jin Park, Su-Hee Jeon, Hyun-Kyung Kim, Eun Jung Suh, Seung Jun Choi, Sinyoung Kim and Hyun Ok Kim

Association between body mass index and survival outcomes for cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis

Immune checkpoint inhibitors (ICIs) have been increasingly applied in the treatment of several kinds of malignancies. Some clinical demographic characteristics were reported to be associated with the ICIs effi...

Authors: Yue An, Zhonghua Wu, Ningning Wang, Zhidong Yang, Yue Li, Boyang Xu and Mingjun Sun

A novel patient-derived organoids-based xenografts model for preclinical drug response testing in patients with colorectal liver metastases

Cancer-related mortality in patients with colorectal cancer (CRC) is predominantly caused by development of colorectal liver metastases (CLMs). How to screen the sensitive chemotherapy and targeted therapy is ...

Authors: Mi Jian, Li Ren, Guodong He, Qi Lin, Wentao Tang, Yijiao Chen, Jingwen Chen, Tianyu Liu, Meiling Ji, Ye Wei, Wenju Chang and Jianmin Xu

COVID-19: viral–host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection

Epidemiological, virological and pathogenetic characteristics of SARS-CoV-2 infection are under evaluation. A better understanding of the pathophysiology associated with COVID-19 is crucial to improve treatmen...

Authors: Francesco Messina, Emanuela Giombini, Chiara Agrati, Francesco Vairo, Tommaso Ascoli Bartoli, Samir Al Moghazi, Mauro Piacentini, Franco Locatelli, Gary Kobinger, Markus Maeurer, Alimuddin Zumla, Maria R. Capobianchi, Francesco Nicola Lauria and Giuseppe Ippolito

A comprehensive custom panel evaluation for routine hereditary cancer testing: improving the yield of germline mutation detection

In the context of our Regional Program of Hereditary Cancer, individuals fulfilling the criteria are tested for germline mutations to subsequently establish the clinical management. Our standard diagnostic app...

Authors: Carolina Velázquez, Enrique Lastra, Francisco Avila Cobos, Luis Abella, Virginia de la Cruz, Blanca Ascensión Hernando, Lara Hernández, Noemí Martínez, Mar Infante and Mercedes Durán

Collapsing the list of myocardial infarction-related differentially expressed genes into a diagnostic signature

Myocardial infarction (MI) is one of the most severe manifestations of coronary artery disease (CAD) and the leading cause of death from non-infectious diseases worldwide. It is known that the central componen...

Authors: German Osmak, Natalia Baulina, Philipp Koshkin and Olga Favorova

Extracellular vesicles in diabetes mellitus induce alterations in endothelial cell morphology and migration

Inflammation-related atherosclerotic peripheral vascular disease is a major end organ complication of diabetes mellitus that results in devastating morbidity and mortality. Extracellular vesicles (EVs) are nan...

Authors: Sharon F. Wu, Nicole Noren Hooten, David W. Freeman, Nicolle A. Mode, Alan B. Zonderman and Michele K. Evans

Eating habits and lifestyle changes during COVID-19 lockdown: an Italian survey

On December 12th 2019, a new coronavirus (SARS-Cov2) emerged in Wuhan, China, sparking a pandemic of acute respiratory syndrome in humans (COVID-19). On the 24th of April 2020, the number of COVID-19 deaths in...

Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Giulia Cinelli, Claudia Leggeri, Giovanna Caparello, Luigi Barrea, Francesco Scerbo, Ernesto Esposito and Antonino De Lorenzo

Physical activity measures in patients with myalgic encephalomyelitis/chronic fatigue syndrome: correlations between peak oxygen consumption, the physical functioning scale of the SF-36 questionnaire, and the number of steps from an activity meter

Most studies to assess effort intolerance in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have used questionnaires. Few studies have compared questionnaires with objective measures...

Authors: C. M. C. van Campen, Peter C. Rowe, Freek W. A. Verheugt and Frans C. Visser

The clinical application of electrical impedance technology in the detection of malignant neoplasms: a systematic review

Electrical impedance technology has been well established for the last 20 years. Recently research has begun to emerge into its potential uses in the detection and diagnosis of pre-malignant and malignant cond...

Authors: Angela A. Pathiraja, Ruwan A. Weerakkody, Alexander C. von Roon, Paul Ziprin and Richard Bayford

Clinical application of the AUC-guided dosage adjustment of docetaxel-based chemotherapy for patients with solid tumours: a single centre, prospective and randomised control study

Docetaxel (DTX) is a widely used anti-tumour drug, and its dosage is solely determined by body surface area (BSA). Adverse events, such as neutropenia or unsatisfied efficacy, likely occur because of differenc...

Authors: Ning Sun, Bo Shen, Jiali Zhu, Xiaomei Zhang, Huayun Zhu, Geyu Liang, Deliang Yang, Jianwei Lu and Yan Zhang

FTY720 ameliorates GvHD by blocking T lymphocyte migration to target organs and by skin fibrosis inhibition

Fibrosis is the formation of excess connective tissue in an organ or tissue during a reparative or reactive process. Graft-versus-host disease (GvHD) is a medical complication of allogeneic tissue transplantat...

Authors: Jaeyoon Ryu, Jooyeon Jhun, Min-Jung Park, Jin-ah Baek, Se-Young Kim, Keun-Hyung Cho, Jeong-Won Choi, Sung-Hwan Park, Jong Young Choi and Mi-La Cho

Genome-wide association study identifies genetic susceptibility loci and pathways of radiation-induced acute oral mucositis

Radiation-induced oral mucositis (OM) is one of the most common acute complications for head and neck cancer. Severe OM is associated with radiation treatment breaks, which harms successful tumor management. R...

Authors: Da-Wei Yang, Tong-Min Wang, Jiang-Bo Zhang, Xi-Zhao Li, Yong-Qiao He, Ruowen Xiao, Wen-Qiong Xue, Xiao-Hui Zheng, Pei-Fen Zhang, Shao-Dan Zhang, Ye-Zhu Hu, Guo-Ping Shen, Mingyuan Chen, Ying Sun and Wei-Hua Jia

A prognostic nomogram integrating novel biomarkers identified by machine learning for cervical squamous cell carcinoma

Cervical cancer (CC) represents the fourth most frequently diagnosed malignancy affecting women all over the world. However, effective prognostic biomarkers are still limited for accurately identifying high-ri...

Authors: Yimin Li, Shun Lu, Mei Lan, Xinhao Peng, Zijian Zhang and Jinyi Lang

SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines

COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effe...

Authors: Giovanni Salvatori, Laura Luberto, Mariano Maffei, Luigi Aurisicchio, Giuseppe Roscilli, Fabio Palombo and Emanuele Marra

The urgency of utilizing COVID-19 biospecimens for research in the heart of the global pandemic

The outbreak of the novel coronavirus disease 2019 (COVID-19) and consequent social distancing practices have disrupted essential clinical research functions worldwide. Ironically, this coincides with an immed...

Authors: Iman Osman, Paolo Cotzia, Una Moran, Douglas Donnelly, Carolina Arguelles-Grande, Sandra Mendoza and Andre Moreira