Articles

Good performance of the criteria of American College of Medical Genetics and Genomics/Association for Molecular Pathology in prediction of pathogenicity of genetic variants causing thoracic aortic aneurysms and dissections

The identification of pathogenic variant in patients with thoracic aortic aneurysms and dissections (TAAD) was previously found to be a significant indicator pointing to earlier need for surgical intervention....

Authors: Joanna Kinga Ponińska, Zofia Teresa Bilińska, Grażyna Truszkowska, Ewa Michalak, Anna Podgórska, Małgorzata Stępień-Wojno, Przemysław Chmielewski, Anna Lutyńska and Rafał Płoski

Autoantigen microarrays reveal myelin basic protein autoantibodies in morphea

Morphea is an autoimmune, sclerosing skin disorder. Despite the recent emphasis on immune dysregulation in morphea, the role of autoantibodies in morphea pathogenesis or utility as biomarkers are poorly defined.

Authors: Jane L. Zhu, Ricardo T. Paniagua, Henry W. Chen, Stephanie Florez-Pollack, Elaine Kunzler, Noelle Teske, Yevgeniya Byekova Rainwater, Quan-Zhen Li, Gregory A. Hosler, Wenhao Li, Denise M. O. Ramirez, Nancy L. Monson and Heidi T. Jacobe

Letter: Could endothelial dysfunction and vascular damage contribute to pain, inflammation and post-exertional malaise in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

Authors: Jeffrey Lubell

Identifying CCR5 coreceptor populations permissive for HIV-1 entry and productive infection: implications for in vivo studies

The chemokine receptor CCR5 is the major coreceptor for HIV-1 cell entry. We previously observed that not all CCR5 mAbs reduce HIV-1 infection, suggesting that only some CCR5 populations are permissive for HIV...

Authors: Matthew Weichseldorfer, Yutaka Tagaya, Marvin Reitz, Anthony L. DeVico and Olga S. Latinovic

CT-based radiomics nomograms for preoperative prediction of diffuse-type and signet ring cell gastric cancer: a multicenter development and validation cohort

The prevalence of diffuse-type gastric cancer (GC), especially signet ring cell carcinoma (SRCC), has shown an upward trend in the past decades. This study aimed to develop computed tomography (CT) based radio...

Authors: Tao Chen, Jing Wu, Chunhui Cui, Qinglie He, Xunjun Li, Weiqi Liang, Xiaoyue Liu, Tianbao Liu, Xuanhui Zhou, Xifan Zhang, Xiaotian Lei, Wei Xiong, Jiang Yu and Guoxin Li

RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment

Ovarian cancer (OC), an important cause of cancer-related death in women worldwide, is one of the most malignant cancers and is characterized by a poor prognosis. RNA-binding proteins (RBPs), a class of endoge...

Authors: Jiangchun Wu, Yong Wu, Qinhao Guo, Simin Wang and Xiaohua Wu

Heart-specific DNA methylation analysis in plasma for the investigation of myocardial damage

Circulating cell-free DNA (cfDNA) can be released when myocardial damage occurs.

Authors: Jie Ren, Lin Jiang, Xiaomeng Liu, Yuhan Liao, Xueyan Zhao, Fuchou Tang, Huimin Yu, Yibing Shao, Jizheng Wang, Lu Wen and Lei Song

Correction to: Identification and functional analysis of a three-miRNA ceRNA network in hypertrophic scars

Authors: Zewei Zhang, Xin Huang, Jiahao Yang, Shuchen Gu, Yixuan Zhao, Yunhan Liu, Yimin Khoong, Shuqi Wang, Shenying Luo, Tao Zan and Guangshuai Li

Point-of-care cell therapy manufacturing; it’s not for everyone

The use of cellular therapies to treat cancer, inherited immune deficiencies, hemoglobinopathies and viral infections is growing rapidly. The increased interest in cellular therapies has led to the development...

Authors: David F. Stroncek, Robert P. T. Somerville and Steven L. Highfill

Pediococcus pentosaceus CECT 8330 protects DSS-induced colitis and regulates the intestinal microbiota and immune responses in mice

Compelling evidences demonstrated that gut microbiota dysbiosis plays a critical role in the pathogenesis of inflammatory bowel diseases (IBD). Therapies for targeting the microbiota may provide alternative op...

Authors: Fang Dong, Fangfei Xiao, Xiaolu Li, Youran Li, Xufei Wang, Guangjun Yu, Ting Zhang and Yizhong Wang

The effect of omega‑3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID‑19: a randomized clinical trial

Authors: Seyedeh Zoha Safaei Ardestani and Seyedeh Tayebeh Rahideh

Development of a radiomics model to diagnose pheochromocytoma preoperatively: a multicenter study with prospective validation

Preoperative diagnosis of pheochromocytoma (PHEO) accurately impacts preoperative preparation and surgical outcome in PHEO patients. Highly reliable model to diagnose PHEO is lacking. We aimed to develop a mag...

Authors: Jianqiu Kong, Junjiong Zheng, Jieying Wu, Shaoxu Wu, Jinhua Cai, Xiayao Diao, Weibin Xie, Xiong Chen, Hao Yu, Lifang Huang, Hongpeng Fang, Xinxiang Fan, Haide Qin, Yong Li, Zhuo Wu, Jian Huang…

Evaluation of exosomal non-coding RNAs in cancer using high-throughput sequencing

Clinical oncologists need more reliable and non-invasive diagnostic and prognostic biomarkers to follow-up cancer patients. However, the existing biomarkers are often invasive and costly, emphasizing the need ...

Authors: Kamran Hosseini, Maryam Ranjbar, Abbas Pirpour Tazehkand, Parina Asgharian, Soheila Montazersaheb, Vahideh Tarhriz and Tohid Ghasemnejad

Incidental germline findings during molecular profiling of tumor tissues for precision oncology: molecular survey and methodological obstacles

A fraction of patients referred for complex molecular profiling of biopsied tumors may harbor germline variants in genes associated with the development of hereditary cancer syndromes (HCS). Neither the bioinf...

Authors: Alexandra Lebedeva, Yulia Shaykhutdinova, Daria Seriak, Ekaterina Ignatova, Ekaterina Rozhavskaya, Divyasphoorthi Vardhan, Sofia Manicka, Margarita Sharova, Tatiana Grigoreva, Ancha Baranova, Vladislav Mileyko and Maxim Ivanov

GDF11 alleviates neointimal hyperplasia in a rat model of artery injury by regulating endothelial NLRP3 inflammasome activation and rapid re-endothelialization

Neointimal hyperplasia induced by interventional surgery can lead to progressive obliteration of the vascular lumen, which has become a major factor affecting prognosis. The rate of re-endothelialization is kn...

Authors: Lei Li, Yan Gao, Zhenchuan Liu, Chenglai Dong, Wenli Wang, Kaiqin Wu, Shaorui Gu and Yongxin Zhou

Ground truth labels challenge the validity of sepsis consensus definitions in critical illness

Sepsis is the leading cause of death in the intensive care unit (ICU). Expediting its diagnosis, largely determined by clinical assessment, improves survival. Predictive and explanatory modelling of sepsis in ...

Authors: Holger A. Lindner, Shigehiko Schamoni, Thomas Kirschning, Corinna Worm, Bianka Hahn, Franz-Simon Centner, Jochen J. Schoettler, Michael Hagmann, Jörg Krebs, Dennis Mangold, Stephanie Nitsch, Stefan Riezler, Manfred Thiel and Verena Schneider-Lindner

First evidence of long-term effects of transcranial pulse stimulation (TPS) on the human brain

With the high spatial resolution and the potential to reach deep brain structures, ultrasound-based brain stimulation techniques offer new opportunities to non-invasively treat neurological and psychiatric dis...

Authors: Eva Matt, Lisa Kaindl, Saskia Tenk, Anicca Egger, Teodora Kolarova, Nejla Karahasanović, Ahmad Amini, Andreas Arslan, Kardelen Sariçiçek, Alexandra Weber and Roland Beisteiner

Correction to: An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Authors: Klaus J. Wirth, Carmen Scheibenbogen and Friedemann Paul

Correction to: Metabolic analysis of early nonalcoholic fatty liver disease in humans using liquid chromatography–mass spectrometry

Authors: Cheng Hu, Tao Wang, Xiaoyu Zhuang, Qiaoli Sun, Xiaochun Wang, Hui Lin, Mingli Feng, Jiaqi Zhang, Qin Cao and Yuanye Jiang

VLCKD: a real time safety study in obesity

Very Low-Calorie Ketogenic Diet (VLCKD) is currently a promising approach for the treatment of obesity. However, little is known about the side effects since most of the studies reporting them were carried out...

Authors: Luigi Barrea, Ludovica Verde, Claudia Vetrani, Francesca Marino, Sara Aprano, Silvia Savastano, Annamaria Colao and Giovanna Muscogiuri

Different decay of antibody response and VOC sensitivity in naïve and previously infected subjects at 15 weeks following vaccination with BNT162b2

COVID-19 vaccines have demonstrated effectiveness in reducing SARS-CoV-2 mild and severe outcomes. In vaccinated subjects with SARS-CoV-2 history, RBD-specific IgG and pseudovirus neutralization titers were ra...

Authors: Gabriel Siracusano, Alessandra Ruggiero, Zeno Bisoffi, Chiara Piubelli, Luca Dalle Carbonare, Maria Teresa Valenti, Martin Mayora-Neto, Nigel Temperton, Lucia Lopalco and Donato Zipeto

VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy

Pathogenic gain of function variants in Valosin-containing protein (VCP) cause a unique disease characterized by inclusion body myopathy with early-onset Paget disease of bone and frontotemporal dementia (also kn...

Authors: Cheng Cheng, Lan Weiss, Henri Leinonen, Alyaa Shmara, Hong Z. Yin, Timothy Ton, Annie Do, Jonathan Lee, Lac Ta, Eshanee Mohanty, Jesse Vargas, John Weiss, Krzysztof Palczewski and Virginia Kimonis

MiR-30c-5p loss-induced PELI1 accumulation regulates cell proliferation and migration via activating PI3K/AKT pathway in papillary thyroid carcinoma

The aberrant expression of E3 ubiquitin ligase Pellino-1 (PELI1) contributes to several human cancer development and progression. However, its expression patterns and functional importance in papillary thyroid...

Authors: Tingting Zheng, Youxing Zhou, Xiaowei Xu, Xin Qi, Jiameng Liu, Yanan Pu, Shan Zhang, Xuerong Gao, Xinkai Luo, Mei Li, Xuefeng Wang, Liyang Dong, Ying Wang and Chaoming Mao

FOXA1 can be modulated by HDAC3 in the progression of epithelial ovarian carcinoma

FOXA1 is associated with malignant tumors, but the function of FOXA1 in EOC is unclear. HDAC3 can influence the proliferation, migration and invasion ability of EOC. In this study, we wanted to explore the fun...

Authors: Tong Lou, Chongdong Liu, Hong Qu, Zhiqiang Zhang, Shuzhen Wang and Huiyu Zhuang

Identification of COPA as a potential prognostic biomarker and pharmacological intervention target of cervical cancer by quantitative proteomics and experimental verification

Cervical cancer is the most fatal gynecological carcinoma in the world. It is urgent to explore novel prognostic biomarkers and intervention targets for cervical cancer.

Authors: Huiqiong Bao, Xiaobin Li, Zhixing Cao, Zhihong Huang, Li Chen, Mingbing Wang, Jiali Hu, Wenting Li, Hongwei Sun, Xue Jiang, Ping Mei, Huawen Li, Ligong Lu and Meixiao Zhan

CTPS1 promotes malignant progression of triple-negative breast cancer with transcriptional activation by YBX1

Cytidine nucleotide triphosphate synthase 1 (CTPS1) is a CTP synthase which play critical roles in DNA synthesis. However, its biological regulation and mechanism in triple-negative breast cancer (TNBC) has no...

Authors: Yuxiang Lin, Jie Zhang, Yan Li, Wenhui Guo, Lili Chen, Minyan Chen, Xiaobin Chen, Wenzhe Zhang, Xuan Jin, Meichen Jiang, Han Xiao, Chuan Wang, Chuangui Song and Fangmeng Fu

Bacterial infections exacerbate myeloma bone disease

Multiple myeloma is characterized by osteolytic lesions caused by reduced bone formation and activated bone resorption. An important feature of myeloma is a failure of bone healing after successful treatment. ...

Authors: Rui Liu, Yuping Zhong, Rui Chen, Shiyi Chen, Yazhu Huang and Huan Liu

Integrated weighted gene coexpression network analysis identifies Frizzled 2 (FZD2) as a key gene in invasive malignant pleomorphic adenoma

Invasive malignant pleomorphic adenoma (IMPA) is a highly malignant neoplasm of the oral salivary glands with a poor prognosis and a considerable risk of recurrence. Many disease-causing genes of IMPA have bee...

Authors: Zhenyuan Han, Huiping Ren, Jingjing Sun, Lihui Jin, Qin Wang, Chuanbin Guo and Zhen Tian

Process development and validation of expanded regulatory T cells for prospective applications: an example of manufacturing a personalized advanced therapy medicinal product

A growing number of clinical trials have shown that regulatory T (T_reg) cell transfer may have a favorable effect on the maintenance of self-tolerance and immune homeostasis in different conditions such as graft-...

Authors: Cristiana Lavazza, Silvia Budelli, Elisa Montelatici, Mariele Viganò, Francesca Ulbar, Lucia Catani, Marta Giulia Cannone, Sara Savelli, Elisa Groppelli, Lorenza Lazzari, Roberto M. Lemoli, Matteo Cescon, Gaetano La Manna, Rosaria Giordano and Tiziana Montemurro

microRNA-155-3p delivered by M2 macrophages-derived exosomes enhances the progression of medulloblastoma through regulation of WDR82

Exosomes, membranous nanovesicles, naturally bringing proteins, mRNAs, and microRNAs (miRNAs), play crucial roles in tumor pathogenesis. This study was to investigate the role of miR-155-3p from M2 macrophages...

Authors: Li Song, Bin Luan, Qingrong Xu, Ruihe Shi and Xiufang Wang

Dysbiosis of vaginal microbiota associated with persistent high-risk human papilloma virus infection

The status of vaginal microbiota in persistent high-risk human papilloma virus (HR-HPV) infection is unclear. The present work aimed to identify the vaginal microbiota of persistent HPV infection and explore t...

Authors: Ling Mei, Tao Wang, Yueyue Chen, Dongmei Wei, Yueting Zhang, Tao Cui, Jian Meng, Xiaoli Zhang, Yuqing Liu, Lisha Ding and Xiaoyu Niu

GM-CSF impairs erythropoiesis by disrupting erythroblastic island formation via macrophages

Anemia is a significant complication of chronic inflammation and may be related to dysregulated activities among erythroblastic island (EBI) macrophages. GM-CSF was reported to be upregulated and attracted as ...

Authors: Weijie Cao, Wenjuan Fan, Fang Wang, Yinyin Zhang, Guanghua Wu, Xiaojing Shi, Jian xiang Shi, Fengcai Gao, Meimei Yan, Rong Guo, Yingmei Li, Wei Li, Chunyan Du and Zhongxing Jiang

Clinical efficiency of simultaneous CNV-seq and whole-exome sequencing for testing fetal structural anomalies

Birth defects are responsible for approximately 7% of neonatal deaths worldwide by World Health Organization in 2004. Many methods have been utilized for examining the congenital anomalies in fetuses. This stu...

Authors: Xinlin Chen, Yulin Jiang, Ruiguo Chen, Qingwei Qi, Xiujuan Zhang, Sheng Zhao, Chaoshi Liu, Weiyun Wang, Yuezhen Li, Guoqiang Sun, Jieping Song, Hui Huang, Chen Cheng, Jianguang Zhang, Longxian Cheng and Juntao Liu

Diabetes, hypertension, and cardiovascular disease development

We aimed to compare cardiovascular risks among participants with T2DM with and without subsequent HTN and participants with HTN with and without subsequent T2DM.

Authors: Fu-Shun Yen, James Cheng-Chung Wei, Lu-Ting Chiu, Chih-Cheng Hsu and Chii-Min Hwu

Comparison of assessment scores for fatigue between multidimensional fatigue inventory (MFI-K) and modified chalder fatigue scale (mKCFQ)

Because of the absence of biological parameters for fatigue, appropriate instruments for assessing the degree of fatigue are important in the diagnosis and management of people complaining of fatigue-like symp...

Authors: Eun-Jin Lim and Chang-Gue Son

Long noncoding RNA NEAT1 promotes cardiac fibrosis in heart failure through increased recruitment of EZH2 to the Smad7 promoter region

Cardiac fibrosis, a well-known major pathological process that ultimately leads to heart failure, has attracted increasing attention and focus in recent years. A large amount of research indicates that long no...

Authors: Zhuowang Ge, Chengye Yin, Yingze Li, Ding Tian, Yin Xiang, Qianhui Li, Yong Tang and Yachen Zhang

The role of Exosomal miRNAs in cancer

Exosomal miRNAs have attracted much attention due to their critical role in regulating genes and the altered expression of miRNAs in virtually all cancers affecting humans (Sun et al. in Mol Cancer 17(1):14, 2...

Authors: Chuanyun Li, Tong Zhou, Jing Chen, Rong Li, Huan Chen, Shumin Luo, Dexi Chen, Cao Cai and Weihua Li

Circulating exosomal hsa_circRNA_0039480 is highly expressed in gestational diabetes mellitus and may be served as a biomarker for early diagnosis of GDM

Gestational diabetes mellitus (GDM) seriously affects the health of mothers and babies, and there are still no effective early diagnostic markers. Therefore, it is necessary to find diagnostic biomarkers for s...

Authors: Bao Jiang, Junfeng Zhang, Xiubin Sun, Chunyan Yang, Guanghui Cheng, Mengru Xu, Siyuan Li and Lina Wang

Increased expression of six-large extracellular vesicle-derived miRNAs signature for nonvalvular atrial fibrillation

Non-valvular atrial fibrillation (AF) is the most common type of cardiac arrhythmia. AF is caused by electrophysiological abnormalities and alteration of atrial tissues, which leads to the generation of abnorm...

Authors: Panjaree Siwaponanan, Pontawee Kaewkumdee, Wilasinee Phromawan, Suthipol Udompunturak, Nusara Chomanee, Kamol Udol, Kovit Pattanapanyasat and Rungroj Krittayaphong

Mendelian randomization study updates the effect of 25-hydroxyvitamin D levels on the risk of multiple sclerosis

Observational studies and previous Mendelian randomization (MR) studies have shown that genetically low 25-hydroxyvitamin D (25OHD) levels are associated with a high susceptibility to multiple sclerosis (MS). ...

Authors: Renxi Wang

Increased burden of cardiovascular disease in people with liver disease: unequal geographical variations, risk factors and excess years of life lost

People with liver disease are at increased risk of developing cardiovascular disease (CVD), however, there has yet been an investigation of incidence burden, risk, and premature mortality across a wide range o...

Authors: Wai Hoong Chang, Stefanie H. Mueller, Sheng-Chia Chung, Graham R. Foster and Alvina G. Lai

Bilirubin ameliorates murine atherosclerosis through inhibiting cholesterol synthesis and reshaping the immune system

Atherosclerosis is a chronic inflammatory disease caused mainly by lipid accumulation and excessive inflammatory immune response. Although the lipid-lowering and cardioprotective properties of bilirubin, as we...

Authors: Guanmei Wen, Leyi Yao, Yali Hao, Jinheng Wang and Jinbao Liu

Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infection

Pronounced sex differences in the susceptibility and response to SARS-CoV-2 infection remain poorly understood. Emerging evidence has highlighted the potential importance of autoimmune activation in modulating...

Authors: Yunxian Liu, Joseph E. Ebinger, Rowann Mostafa, Petra Budde, Jana Gajewski, Brian Walker, Sandy Joung, Min Wu, Manuel Bräutigam, Franziska Hesping, Elena Rupieper, Ann-Sophie Schubert, Hans-Dieter Zucht, Jonathan Braun, Gil Y. Melmed, Kimia Sobhani…

“Forever young at the table”: metabolic effects of eating speed in obesity

Cardiometabolic diseases (CMD) are recognized as the main causes of morbidity and mortality in developed countries. In recent years eating speed (ES) has been of particular interest since some studies have ass...

Authors: Luigi Barrea, Claudia Vetrani, Ludovica Verde, Bruno Napolitano, Silvia Savastano, Annamaria Colao and Giovanna Muscogiuri

Prognostic significance of natural killer cell-associated markers in gastric cancer: quantitative analysis using multiplex immunohistochemistry

Natural killer (NK) cells mediate the anti-tumoral immune response as an important component of innate immunity. The aim of this study was to investigate the prognostic significance and functional implication ...

Authors: Hee Young Na, Yujun Park, Soo Kyung Nam, Jiwon Koh, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Kyu Sang Lee and Hye Seung Lee

Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study

Emerging evidence shows that periodontal disease (PD) may increase the risk of Coronavirus disease 2019 (COVID-19) complications. Here, we undertook a two-sample Mendelian randomization (MR) study, and investi...

Authors: Yi Wang, Hui Deng, Yihuai Pan, Lijian Jin, Rongdang Hu, Yongyong Lu, Wenhai Deng, Weijian Sun, Chengshui Chen, Xian Shen and Xiu-Feng Huang

Analysis and validation of m6A regulatory network: a novel circBACH2/has-miR-944/HNRNPC axis in breast cancer progression

N6-methyladenosine (m6A), the most abundant and reversible modification of mRNAs in eukaryotes, plays pivotal role in breast cancer (BC) tumorigenesis and progression. Circular RNAs (circRNAs) can act as tumor...

Authors: Wenchang Lv, Yufang Tan, Mingchen Xiong, Chongru Zhao, Yichen Wang, Min Wu, Yiping Wu and Qi Zhang

Long-term memory T cells as preventive anticancer immunity elicited by TuA-derived heteroclitic peptides

The host’s immune system may be primed against antigens during the lifetime (e.g. microorganisms antigens—MoAs), and swiftly recalled upon growth of a tumor expressing antigens similar in sequence and structur...

Authors: Angela Mauriello, Beatrice Cavalluzzo, Carmen Manolio, Concetta Ragone, Antonio Luciano, Antonio Barbieri, Maria Lina Tornesello, Franco M. Buonaguro, Maria Tagliamonte and Luigi Buonaguro

A novel staging system and clinical predictive nomogram for more accurate staging and prognosis of malignant pancreatic intraductal papillary mucinous neoplasms: a population-based study

The current guidelines of the American Joint Committee on Cancer (AJCC) for the staging of exocrine pancreatic tumors seem inapplicable to malignant pancreatic intraductal papillary mucinous neoplasms (IPMN). ...

Authors: Haoxiang Zhang, Chenggang Gao, Jiaoshun Chen, Shihong Wu, Jianwei Bai and Tao Yin

Establishment and validation of in-house cryopreserved CAR/TCR-T cell flow cytometry quality control

Chimeric antigen receptor (CAR) or T-cell receptor (TCR) engineered T-cell therapy has recently emerged as a promising adoptive immunotherapy approach for the treatment of hematologic malignancies and solid tu...

Authors: Yihua Cai, Michaela Prochazkova, Chunjie Jiang, Hannah W. Song, Jianjian Jin, Larry Moses, Nikolaos Gkitsas, Robert P. Somerville, Steven L. Highfill, Sandhya Panch, David F. Stroncek and Ping Jin