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  1. Recently, involvement of IL-19, IL-20 and IL-24 has been reported in inflammatory diseases associated with tissue remodeling. However, their impact on the pathomechanism of coeliac disease (CD) is still comple...

    Authors: Réka Rokonay, Apor Veres-Székely, Beáta Szebeni, Domonkos Pap, Rita Lippai, Nóra J. Béres, Gábor Veres, Attila J. Szabó and Ádám Vannay

    Citation: Journal of Translational Medicine 2020 18:36

    Content type: Research

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  2. We have previously shown that HCC patients and healthy subjects are equally responsive to a RNAdjuvant®, a novel TLR-7/8/RIG-I agonist based on noncoding RNA developed by CureVac, by an ex vivo evaluation. Howeve...

    Authors: Angela Mauriello, Carmen Manolio, Beatrice Cavalluzzo, Antonio Avallone, Marco Borrelli, Alessandro Morabito, Emanuele Iovine, Angela Chambery, Rosita Russo, Maria Lina Tornesello, Franco M. Buonaguro, Maria Tagliamonte and Luigi Buonaguro

    Citation: Journal of Translational Medicine 2020 18:34

    Content type: Research

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  3. During pregnancy in humans, the physiology of the mother and foetus are finely regulated by many factors. Inappropriate regulation can result in pregnancy disorders, such as complications and foetal abnormalit...

    Authors: Haiou Yang, Qianqian Ma, Yu Wang and Zhenhua Tang

    Citation: Journal of Translational Medicine 2020 18:32

    Content type: Review

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  4. Chronic inflammation is a risk factor for head and neck squamous cell carcinoma (HNSCC) and other diseases. Prostanoid receptors are clearly involved in the development of many types of cancer. However, their ...

    Authors: Kiyoshi Misawa, Masato Mima, Yamada Satoshi, Atsushi Imai, Daiki Mochizuki, Ryuji Ishikawa, Junya Kita, Yuki Yamaguchi, Shiori Endo, Yuki Misawa and Hiroyuki Mineta

    Citation: Journal of Translational Medicine 2020 18:31

    Content type: Research

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  6. Cardiovascular disease (CVD) is the leading cause of death in the world. Given the role of immune cells in atherosclerosis development and progression, effective methods for characterizing immune cell populati...

    Authors: Yvonne Baumer, Cristhian A. Gutierrez-Huerta, Ankit Saxena, Pradeep K. Dagur, Steven D. Langerman, Kosuke Tamura, Joniqua N. Ceasar, Marcus R. Andrews, Valerie Mitchell, Billy S. Collins, Quan Yu, Heather L. Teague, Martin P. Playford, Christopher K. E. Bleck, Nehal N. Mehta, J. Philip McCoy…

    Citation: Journal of Translational Medicine 2020 18:29

    Content type: Research

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  7. Pain is the vital sense preventing tissue damage by harmful noxious stimuli. The capsaicin receptor TRPV1 is activated by noxious temperatures, however, acute heat pain is only marginally affected in mice afte...

    Authors: Daniela C. Rosenberger, Uta Binzen, Rolf-Detlef Treede and Wolfgang Greffrath

    Citation: Journal of Translational Medicine 2020 18:28

    Content type: Research

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  8. After publication of abstract S 2‑06 in supplement [1], it was brought to our attention that the second author’s name is spelled incorrectly. Originally the author name has been published as Rajesh Sarma. The ...

    Authors: Choel Kim, Rajesh Sharma and Darren E. Casteel

    Citation: Journal of Translational Medicine 2020 18:27

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2019 17:254

  9. Upon publication of the original article [1], it was noticed that Jun Tao’s affiliation information is not complete. The full affiliation information for Jun Tao can be found below and in the complete affiliat...

    Authors: Jianwen Liang, Yan Li, Long Chen, Wenhao Xia, Guifu Wu, Xinzhu Tong, Chen Su, Jiang He, Xiufang Lin and Jun Tao

    Citation: Journal of Translational Medicine 2020 18:26

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2019 17:368

  10. Immune checkpoint inhibitors are effective in some cases of lung adenocarcinoma (LUAD). Whole-exome sequencing has revealed that the tumour mutation burden (TMB) is associated with clinical benefits among pati...

    Authors: Ying Li, Wenbin Jiang, Tianhao Li, Mengyue Li, Xin Li, Zheyang Zhang, Sainan Zhang, Yixin Liu, Wenyuan Zhao, Yunyan Gu, Lishuang Qi, Lu Ao and Zheng Guo

    Citation: Journal of Translational Medicine 2020 18:25

    Content type: Research

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  11. Bone marrow mononuclear cells have been successfully utilized for numerous regenerative purposes. In the current study, patients suffering from erectile dysfunction (ED) unresponsive to phosphodiesterase 5 inh...

    Authors: Mark Bieri, Elias Said, Gabrielle Antonini, Donald Dickerson, Jorge Tuma, Courtney E. Bartlett, Amit N. Patel and Alexander Gershman

    Citation: Journal of Translational Medicine 2020 18:24

    Content type: Research

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  12. Prostate cancer is one of the most common adult malignancies in men, and nearly all patients with metastatic prostate cancer can develop and receive resistance to primary androgen deprivation therapy (ADT), a ...

    Authors: Dawei Wang, Yuan Shao, Xiang Zhang, Guoliang Lu and Boke Liu

    Citation: Journal of Translational Medicine 2020 18:23

    Content type: Research

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  13. A correct perception of the body image, as defined by comparison with actual anthropometric analyses, is crucial to ensure the best possible nutritional status of each individual. Bioimpedance analysis (BIA) r...

    Authors: Luciana Zaccagni, Natascia Rinaldo, Barbara Bramanti, Jessica Mongillo and Emanuela Gualdi-Russo

    Citation: Journal of Translational Medicine 2020 18:20

    Content type: Research

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  14. The temporomandibular joint (TMJ) is well innervated by braches of the trigeminal nerve. The temporomandibular joint disorders (TMD) can cause neural-inflammation in the peripheral nervous system (PNS) at the ...

    Authors: Andre Barkhordarian, Gary Demerjian and Francesco Chiappelli

    Citation: Journal of Translational Medicine 2020 18:22

    Content type: Research

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  15. Tetralogy of Fallot (ToF) and Atrial Septal Defects (ASD) are the most common types of congenital heart diseases and a major cause of childhood morbidity and mortality. Cardiopulmonary bypass (CPB) is used dur...

    Authors: Federica Raggi, Davide Cangelosi, Pamela Becherini, Fabiola Blengio, Martina Morini, Massimo Acquaviva, Maria Luisa Belli, Giuseppe Panizzon, Giuseppe Cervo, Luigi Varesio, Alessandra Eva and Maria Carla Bosco

    Citation: Journal of Translational Medicine 2020 18:21

    Content type: Research

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  16. The manipulation of gut microbiota as a target has been suggested to reduce the risks for a number of diseases such as type 2 diabetes mellitus (T2DM). Conversely, T2DM is associated with complications such as...

    Authors: Mohammad Morshedi, Maryam Saghafi-Asl and Elaheh-Sadat Hosseinifard

    Citation: Journal of Translational Medicine 2020 18:18

    Content type: Research

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  17. Recent studies have shown that selenium-binding protein 1 (SELENBP1) is significantly down-regulated in a variety of solid tumors. Nevertheless, the clinical relevance of SELENBP1 in human bladder cancer has n...

    Authors: Yulei Wang, Wenzhen Zhu, Xiaoqing Chen, Guangnan Wei, Guosong Jiang and Guochun Zhang

    Citation: Journal of Translational Medicine 2020 18:17

    Content type: Research

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  18. Epidemiologic studies show that cocaine- and amphetamine-regulated transcript prepropeptide (CARTPT) gene polymorphism modifies diet-obesity relationships. However, the interaction between CARTPT gene polymorp...

    Authors: Mahsa Mahmoudi-Nezhad, Mahdieh Abbasalizad Farhangi and Houman Kahroba

    Citation: Journal of Translational Medicine 2020 18:16

    Content type: Research

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  20. Artificial intelligence (AI), with its seemingly limitless power, holds the promise to truly revolutionize patient healthcare. However, the discourse carried out in public does not always correlate with the ac...

    Authors: M.-C. Laï, M. Brian and M.-F. Mamzer

    Citation: Journal of Translational Medicine 2020 18:14

    Content type: Research

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  21. Melanoma patients with metastatic growth in the meninges have poor prognosis and few treatment options. Although treatment with BRAF inhibitors or immune checkpoint inhibitors has provided promising results, m...

    Authors: Trude G. Simonsen, Jon-Vidar Gaustad and Einar K. Rofstad

    Citation: Journal of Translational Medicine 2020 18:13

    Content type: Research

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  22. Malignant behavior and radioresistance, which severely limits the efficacy of radiation therapy (RT) in nasopharyngeal carcinoma (NPC), are associated with tumor progression and poor prognosis. Mesenchymal ste...

    Authors: Fang-Zhu Wan, Kai-Hua Chen, Yong-Chu Sun, Xi-Chan Chen, Ren-Ba Liang, Li Chen and Xiao-Dong Zhu

    Citation: Journal of Translational Medicine 2020 18:12

    Content type: Research

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  23. Most oral squamous cell carcinomas (OSCC) occur on the basis of oral leukoplakias (OLP). The histologic degree of dysplasia is insufficient for the prediction of OLP malignant transformation. Immunologic param...

    Authors: Manuel Weber, Falk Wehrhan, Christoph Baran, Abbas Agaimy, Maike Büttner-Herold, Hatice Öztürk, Kristina Neubauer, Claudia Wickenhauser, Marco Kesting and Jutta Ries

    Citation: Journal of Translational Medicine 2020 18:11

    Content type: Research

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  24. Predicting the clinical course of prostate cancer is challenging due to the wide biological spectrum of the disease. The objective of our study was to identify prostate cancer prognostic markers in patients ‘s...

    Authors: Michael A. Kiebish, Jennifer Cullen, Prachi Mishra, Amina Ali, Eric Milliman, Leonardo O. Rodrigues, Emily Y. Chen, Vladimir Tolstikov, Lixia Zhang, Kiki Panagopoulos, Punit Shah, Yongmei Chen, Gyorgy Petrovics, Inger L. Rosner, Isabell A. Sesterhenn, David G. McLeod…

    Citation: Journal of Translational Medicine 2020 18:10

    Content type: Research

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  25. The timely diagnosis of bacterial meningitis is of utmost importance due to the need to institute antibiotic treatment as early as possible. Moreover, the differentiation from other causes of meningitis/enceph...

    Authors: Leonardo Silva de Araujo, Kevin Pessler, Kurt-Wolfram Sühs, Natalia Novoselova, Frank Klawonn, Maike Kuhn, Volkhard Kaever, Kirsten Müller-Vahl, Corinna Trebst, Thomas Skripuletz, Martin Stangel and Frank Pessler

    Citation: Journal of Translational Medicine 2020 18:9

    Content type: Research

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  26. Serum protein glycosylation is an area of investigation in inflammatory arthritic disorders such as rheumatoid arthritis (RA). Indeed, some studies highlighted abnormalities of protein glycosylation in RA. Con...

    Authors: Federica Ciregia, Dominique Baiwir, Gaël Cobraiville, Thibaut Dewael, Gabriel Mazzucchelli, Valérie Badot, Silvana Di Romana, Paschalis Sidiras, Tatiana Sokolova, Patrick Durez, Michel G. Malaise and Dominique de Seny

    Citation: Journal of Translational Medicine 2020 18:8

    Content type: Research

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  27. Although medical requirements are urgent, no effective intervention has been proven for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). To facilitate the development of new therapeutics, we system...

    Authors: Do-Young Kim, Jin-Seok Lee, Samuel-Young Park, Soo-Jin Kim and Chang-Gue Son

    Citation: Journal of Translational Medicine 2020 18:7

    Content type: Review

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  28. The Spanish HIV HGM BioBank is of great relevance for basic and clinical investigation, and for those groups trying to establish large networks focused on investigation on specific clinical problems. The colle...

    Authors: Irene Consuegra Fernández, Isabel García Merino and María Ángeles Muñoz-Fernández

    Citation: Journal of Translational Medicine 2020 18:6

    Content type: Research

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  29. Sepsis remains a major challenge in intensive care units, causing unacceptably high mortality rates due to the lack of rapid diagnostic tools with sufficient sensitivity. Therefore, there is an urgent need to ...

    Authors: Pei Chen, Shuo Li, Wenyuan Li, Jie Ren, Fengzhu Sun, Rui Liu and Xianghong Jasmine Zhou

    Citation: Journal of Translational Medicine 2020 18:5

    Content type: Research

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  30. Heart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend to have lower HRV; how...

    Authors: Rosa María Escorihuela, Lluís Capdevila, Juan Ramos Castro, María Cleofé Zaragozà, Sara Maurel, José Alegre and Jesús Castro-Marrero

    Citation: Journal of Translational Medicine 2020 18:4

    Content type: Research

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  31. The prevalence of autoimmune hepatitis (AIH) is increasing, and its early clinical diagnosis is difficult. The pathogenesis of AIH remains unclear, and AIH-related studies are largely limited because of lack o...

    Authors: Han Wang, Wei Yan, Zuohua Feng, Yuan Gao, Liu Zhang, Xinxia Feng and Dean Tian

    Citation: Journal of Translational Medicine 2020 18:3

    Content type: Research

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  32. Tumor cells have evolved complex strategies to escape immune surveillance, a process which involves NK cells and T lymphocytes, and various immunological factors. Indeed, tumor cells recruit immunosuppressive ...

    Authors: Raquel Alves, Stephanie E. B. McArdle, Jayakumar Vadakekolathu, Ana Cristina Gonçalves, Paulo Freitas-Tavares, Amélia Pereira, Antonio M. Almeida, Ana Bela Sarmento-Ribeiro and Sergio Rutella

    Citation: Journal of Translational Medicine 2020 18:2

    Content type: Research

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  33. The present review aimed to discuss contemporary scientific literature involving differences between the tumor microenvironment (TME) in melanoma, lung cancer, and breast cancer in their primary site and TME i...

    Authors: Bernardo Cacho-Díaz, Donovan R. García-Botello, Talia Wegman-Ostrosky, Gervith Reyes-Soto, Elizabeth Ortiz-Sánchez and Luis Alonso Herrera-Montalvo

    Citation: Journal of Translational Medicine 2020 18:1

    Content type: Review

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  34. Breast cancer (BrC) remains the leading cause of cancer-related death in women, mainly due to recurrent and/or metastatic events, entailing the need for biomarkers predictive of progression to advanced disease...

    Authors: Helena Estevão-Pereira, João Lobo, Sofia Salta, Maria Amorim, Paula Lopes, Mariana Cantante, Berta Reis, Luís Antunes, Fernando Castro, Susana Palma de Sousa, Céline S. Gonçalves, Bruno M. Costa, Rui Henrique and Carmen Jerónimo

    Citation: Journal of Translational Medicine 2019 17:435

    Content type: Research

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  35. A worldwide lack of donor corneas demands the bioengineered corneas be developed as an alternative. The primary objective of the current study was to evaluate the efficacy of acellular porcine corneal stroma (...

    Authors: Saiqun Li, Meng Li, Li Gu, Lulu Peng, Yuqing Deng, Jing Zhong, Bowen Wang, Qian Wang, Yichen Xiao and Jin Yuan

    Citation: Journal of Translational Medicine 2019 17:434

    Content type: Research

    Published on:

  36. Gap junctions are involved in the development of cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH). However, the specific roles and regulatory functions of related connexin isoforms remain unknown. ...

    Authors: Le Yang, Jian Yan, Jin-An Zhang, Xin-Hui Zhou, Chao Fang, Er-Ming Zeng, Bin Tang, Jian Duan, Guo-Hui Lu and Tao Hong

    Citation: Journal of Translational Medicine 2019 17:433

    Content type: Research

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  37. Innovative human stromal cell therapeutics require xeno-free culture conditions. Various formulations of human platelet lysate (HPL) are efficient alternatives for fetal bovine serum (FBS). However, a consiste...

    Authors: Sandra Laner-Plamberger, Michaela Oeller, Cornelia Mrazek, Arnulf Hartl, Alina Sonderegger, Eva Rohde, Dirk Strunk and Katharina Schallmoser

    Citation: Journal of Translational Medicine 2019 17:432

    Content type: Research

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  38. Telocytes (TCs) have the capacity of cell–cell communication with adjacent cells within the tissue, contributing to tissue repair and recovery from injury. The present study aims at investigating the molecular...

    Authors: Dongli Song, Li Tang, Jianan Huang, Lu Wang, Tao Zeng and Xiangdong Wang

    Citation: Journal of Translational Medicine 2019 17:431

    Content type: Research

    Published on:

  39. Lung cancer is the leading cause of cancer-related death worldwide, and the timely and serial assessment of low-dose computed tomography (LDCT) in high-risk populations remains a challenge. Furthermore, testin...

    Authors: Ruochuan Zang, Xinfeng Wang, Runsen Jin, Yuanyuan Lei, Jianbing Huang, Chengming Liu, Sufei Zheng, Fang Zhou, Qian Wu, Nan Sun, Shugeng Gao and Jie He

    Citation: Journal of Translational Medicine 2019 17:430

    Content type: Research

    Published on:

  40. Programmed cell death ligand-1 (PD-L1) expression on tumor cells (TCs) is associated with improved survival in patients with head and neck squamous cell carcinoma (HNSCC) treated with immunotherapy, although i...

    Authors: Sara I. Pai, Ezra E. W. Cohen, Derrick Lin, George Fountzilas, Edward S. Kim, Holger Mehlhorn, Neus Baste, Daniel Clayburgh, Loren Lipworth, Carlo Resteghini, Nawar Shara, Takashi Fujii, Jun Zhang, Michael Stokes, Huifen Wang, Philip Twumasi-Ankrah…

    Citation: Journal of Translational Medicine 2019 17:429

    Content type: Research

    Published on:

  41. Epithelial ovarian cancer (EOC) is the most lethal cancer in female genital tumors. New disease markers and novel therapeutic strategies are urgent to identify considering the current status of treatment. Rece...

    Authors: Rui Li, Tianfeng Liu, Juanjuan Shi, Wenqing Luan, Xuan Wei, Jiangtao Yu, Hongluan Mao and Peishu Liu

    Citation: Journal of Translational Medicine 2019 17:428

    Content type: Research

    Published on:

  42. Telocytes (TCs) are newly identified interstitial cells that participate in tissue protection and repair. The present study investigated the mechanisms underlying the protective effect of TCs in a mouse model ...

    Authors: Yile Zhou, Yajie Yang, Tao Liang, Yan Hu, Haihong Tang, Dongli Song and Hao Fang

    Citation: Journal of Translational Medicine 2019 17:427

    Content type: Research

    Published on:

  43. Neuropsychiatric manifestations are frequent in patients with systemic lupus erythematosus (SLE), yet the etiology and pathogenesis of brain damage in SLE remains unclear. Because the production of autoantibod...

    Authors: Chunshu Yang, Xiaoyu Hou, Qianhui Feng, Yingzhuo Li, Xuejiao Wang, Ling Qin and Pingting Yang

    Citation: Journal of Translational Medicine 2019 17:426

    Content type: Research

    Published on:

  44. Spontaneously metastatic xenograft models of cancer are infrequent and the few that exist are resource intensive. In xenografts, caliper measurements can be used to determine primary tumor burden and response ...

    Authors: James L. Tatum, Joseph D. Kalen, Paula M. Jacobs, Lilia V. Ileva, Lisa A. Riffle, Melinda G. Hollingshead and James H. Doroshow

    Citation: Journal of Translational Medicine 2019 17:425

    Content type: Methodology

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  45. The inefficacy of standard therapeutic strategies for ovarian cancer is reflected by the enduring poor prognosis of this malignancy. Due to the potential for exquisite specificity, sensitivity and long-term me...

    Authors: Leonardo Mirandola, Maurizio Chiriva-Internati, Robert Bresalier, Lucia Piccotti, Fabio Grizzi and Francesco M. Marincola

    Citation: Journal of Translational Medicine 2019 17:424

    Content type: Research

    Published on:

  46. Lung cancer (LC) is one of the most lethal and most prevalent malignant tumors, and its incidence and mortality are increasing annually. Lung adenocarcinoma (LUAD) is the most common pathological type of lung ...

    Authors: Lei Zhang, Zhe Zhang and Zhenglun Yu

    Citation: Journal of Translational Medicine 2019 17:423

    Content type: Research

    Published on:

  47. The growth differentiation factor 11 (GDF11) was shown to reverse age-related hypertrophy on cardiomyocytes and considered as anti-aging rejuvenation factor. The role of GDF11 in regulating metabolic homeostas...

    Authors: Bingxin Lu, Jianing Zhong, Jianfei Pan, Xiaopeng Yuan, Mingzhi Ren, Liping Jiang, Yuqing Yang, Guisheng Zhang, Dexi Liu and Chunbo Zhang

    Citation: Journal of Translational Medicine 2019 17:422

    Content type: Research

    Published on:

  48. Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer associated with a high mortality. Long non-coding RNAs (lncRNAs) have recently emerged as regulators in the development and progression ...

    Authors: Weiwei Wang, Guoyong Chen, Bing Wang, Zhenhua Yuan, Guangbo Liu, Biao Niu, Yongfeng Chen, Shaotang Zhou, Junchuang He and Huanzhou Xue

    Citation: Journal of Translational Medicine 2019 17:421

    Content type: Research

    Published on:

  49. Polymorphonuclear (PMN) elastase plays an important role in a variety of inflammatory disorders. Our aim was to analyse PMN elastase in idiopathic inflammatory myopathies (IIMs) and its association with diseas...

    Authors: Siyu Wu, Wanchan Peng, Yunli Zhang, Jingjing Guo, Jinfang Fu and Wei Wang

    Citation: Journal of Translational Medicine 2019 17:420

    Content type: Research

    Published on:

  50. Tacrolimus (FK506)-induced diabetes mellitus is one of the most important factors of post-transplant diabetes mellitus (PTDM). However, the detailed mechanisms underlying PTDM are still unclear. Farnesoid X re...

    Authors: Ling Li, Huijia Zhao, Binyao Chen, Zhipeng Fan, Ning Li, Jiang Yue and Qifa Ye

    Citation: Journal of Translational Medicine 2019 17:418

    Content type: Research

    Published on:

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Journal of Translational Medicine

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