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  1. The objectives of the study were to characterize and quantify cellular inflammation and structural remodeling of human atria and correlate findings with molecular markers of inflammation and patient surrogate ...

    Authors: Christie M. Aguiar, Kareem Gawdat, Stephanie Legere, Jean Marshall, Ansar Hassan, Petra C. Kienesberger, Thomas Pulinilkunnil, Mathieu Castonguay, Keith R. Brunt and Jean-Francois Legare

    Citation: Journal of Translational Medicine 2019 17:413

    Content type: Research

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  2. The liver is supplied by a dual blood supply, including the portal venous system and the hepatic arterial system; thus, the liver organ is exposed to multiple gut microbial products, metabolic products, and to...

    Authors: Chenxia Hu and Lanjuan Li

    Citation: Journal of Translational Medicine 2019 17:412

    Content type: Review

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  3. This study aimed to establish and validate a nomogram for predicting brain metastasis in patients with bladder cancer (BCa) and assess various treatment modalities using a primary cohort comprising 234 patient...

    Authors: Zhixian Yao, Zhong Zheng, Wu Ke, Renjie Wang, Xingyu Mu, Feng Sun, Xiang Wang, Shivank Garg, Wenyin Shi, Yinyan He and Zhihong Liu

    Citation: Journal of Translational Medicine 2019 17:411

    Content type: Research

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  4. Currently, many clinical trials have shown that inulin-type fructans (ITF) supplementation is associated with glycemic control; nevertheless, the results are inconclusive. The aim of this meta-analysis of rand...

    Authors: Long Wang, Hong Yang, Hao Huang, Chao Zhang, Hong-Xia Zuo, Pan Xu, Yu-Ming Niu and Shi-Shi Wu

    Citation: Journal of Translational Medicine 2019 17:410

    Content type: Research

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  5. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterised by fatigue and post-exertional malaise. Its pathogenesis is poorly understood. GDF15 is a circulating prote...

    Authors: A. Melvin, E. Lacerda, H. M. Dockrell, S. O’Rahilly and L. Nacul

    Citation: Journal of Translational Medicine 2019 17:409

    Content type: Research

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  6. Non-alcoholic fatty liver disease (NAFLD) is characterized by triglyceride accumulation in the hepatocytes in the absence of alcohol overconsumption, commonly associated with insulin resistance and obesity. Bo...

    Authors: Benedetta M. Motta, Christoph Grander, Martin Gögele, Luisa Foco, Vladimir Vukovic, Roberto Melotti, Christian Fuchsberger, Alessandro De Grandi, Chiara Cantaloni, Anne Picard, Deborah Mascalzoni, Alessandra Rossini, Cristian Pattaro, Herbert Tilg and Peter P. Pramstaller

    Citation: Journal of Translational Medicine 2019 17:408

    Content type: Protocol

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  7. Tumor surrounding the internal carotid artery or invading to the cavernous sinus is an important characteristic of invasive pituitary adenoma, and a pivotal factor of tumor residue and regrowth. Without specif...

    Authors: Sen Cheng, Weiyan Xie, Yazhou Miao, Jing Guo, Jichao Wang, Chuzhong Li and Yazhuo Zhang

    Citation: Journal of Translational Medicine 2019 17:407

    Content type: Research

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  8. The NLRP3 inflammasome plays an important role in mediating podocyte injury in various kidney diseases. The aim of this study was to investigate whether NLRP3 expression associated with podocyte injury was inv...

    Authors: Wei Peng, Gai-qin Pei, Yi Tang, Li Tan and Wei Qin

    Citation: Journal of Translational Medicine 2019 17:406

    Content type: Research

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  9. The current study aimed to construct competing endogenous RNA (ceRNA) regulation network and develop two precision medicine predictive tools for colorectal cancer (CRC).

    Authors: Zhiqiao Zhang, Tingshan He, Liwen Huang, Yanling Ouyang, Jing Li, Yiyan Huang, Peng Wang and Jianqiang Ding

    Citation: Journal of Translational Medicine 2019 17:405

    Content type: Research

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  10. As a peripheral blood biomarker, the crucial role of long non-coding RNA (lncRNA) HOTAIR has recently been suggested in many types of disorder. Among these reports, few investigations have indicated overexpres...

    Authors: Vahid Ezzatizadeh and Hossein Mozdarani

    Citation: Journal of Translational Medicine 2019 17:404

    Content type: Commentary

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  11. Although there is abundant evidence indicating the connection between triglyceride and type 2 diabetes mellitus (T2DM), few reports or cohort studies confirm that high TG concentration may predict the incidenc...

    Authors: Jing Zhao, Yuan Zhang, Fengjiang Wei, Jiani Song, Zhi Cao, Chen Chen, Kai Zhang, Shuzhi Feng, Yaogang Wang and Wei-Dong Li

    Citation: Journal of Translational Medicine 2019 17:403

    Content type: Research

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  12. Immunosuppression caused by tumorigenesis may promote tumor progress and invasion. Here, we investigated whether the characteristics of circulating T lymphocyte subtypes in patients with extensive small cell l...

    Authors: Ning An, Haoyi Wang, Wenxiao Jia, Wang Jing, Chao Liu, Hui Zhu and Jinming Yu

    Citation: Journal of Translational Medicine 2019 17:402

    Content type: Research

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  13. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is hallmarked by a significant reduction in natural killer (NK) cell cytotoxicity, a mechanism tightly regulated by calcium (Ca2+). Interestingly, inter...

    Authors: Cassandra Balinas, Helene Cabanas, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Journal of Translational Medicine 2019 17:401

    Content type: Research

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  14. Xenon (Xe) is a noble gas that has been used for the last several decades as an anesthetic during surgery. Its antagonistic effect on glutamate subtype of NMDA (N-methyl-d-aspartate) receptors resulted in evaluat...

    Authors: A. P. Dobrovolsky, V. R. Gedzun, V. I. Bogin, D. Ma, T. E. Ichim, Iu. A. Sukhanova, A. V. Malyshev and V. A. Dubynin

    Citation: Journal of Translational Medicine 2019 17:400

    Content type: Research

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  15. Mesenchymal stem cells (MSCs) represent an invaluable asset for the field of cell therapy. Human Bone marrow-derived MSCs (hBM-MSCs) are one of the most commonly used cell types in clinical trials. They are cu...

    Authors: Soukaina Bahsoun, Karen Coopman and Elizabeth C. Akam

    Citation: Journal of Translational Medicine 2019 17:397

    Content type: Review

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  16. The aim of this systematic review study is to summarize the current knowledge of ovarian tissue transplantation and provide insight on ovarian function, fertility and reproductive outcome following ovarian tis...

    Authors: Sepideh Sheshpari, Mahnaz Shahnazi, Halimeh Mobarak, Shahin Ahmadian, Alberto Miranda Bedate, Ziba Nariman-Saleh-Fam, Mohammad Nouri, Reza Rahbarghazi and Mahdi Mahdipour

    Citation: Journal of Translational Medicine 2019 17:396

    Content type: Review

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  17. Since both genomic and environmental factors are involved in obesity etiology, several studies about the influence of adiposity on both nuclear DNA and mitochondrial DNA methylation patterns have been carried ...

    Authors: Laura Bordoni, Vanessa Smerilli, Cinzia Nasuti and Rosita Gabbianelli

    Citation: Journal of Translational Medicine 2019 17:399

    Content type: Research

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  18. Patients with atypical values of HCG and/or PAPP-A are at higher risk of chromosomal abnormality and vascular complications of pregnancy. The performance of cfDNA in this particular population has not yet been...

    Authors: Julie Carrara, Alexandre Vivanti, Jacques C. Jani, Adèle Demain, Jean-Marc Costa and Alexandra Benachi

    Citation: Journal of Translational Medicine 2019 17:398

    Content type: Research

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  20. Bladder cancer (BC) is the most common malignant disease of the urinary tract. Recurrent high grade non muscle invasive BC carries a serious risk for progression and subsequent metastases. The most common prec...

    Authors: Marina Degoricija, Jelena Korac-Prlic, Katarina Vilovic, Tonci Ivanisevic, Benedikt Haupt, Vinko Palada, Marina Petkovic, Ivana Karaman and Janos Terzic

    Citation: Journal of Translational Medicine 2019 17:394

    Content type: Research

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  21. RH1 is one of the most clinically important blood group antigens in the field of transfusion and in the prevention of fetal incompatibility. The molecular analysis and characterization of serologic weak D phen...

    Authors: Xu Zhang, Guiji Li, Zhuren Zhou, Chaopeng Shao, Xuying Huang, Lichun Li, Xiaofeng Li, Ying Liu, Hua Fan and Jianping Li

    Citation: Journal of Translational Medicine 2019 17:393

    Content type: Research

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  22. The “nonclassic” apparent mineralocorticoid excess (NC-AME) has been identified in approximately 7% of general population. This phenotype is characterized by low plasma renin activity (PRA), high serum cortiso...

    Authors: Alejandra Tapia-Castillo, Dominic Guanzon, Carlos Palma, Andrew Lai, Eric Barros, Fidel Allende, Andrea Vecchiola, Carlos E. Fardella, Carlos Salomón and Cristian A. Carvajal

    Citation: Journal of Translational Medicine 2019 17:392

    Content type: Research

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  23. Most ovarian cancer patients are diagnosed at a late stage with 85% of them relapsing after surgery and standard chemotherapy; for this reason, new treatments are urgently needed. Ovarian cancer has become a c...

    Authors: Apostolos Sarivalasis, Caroline Boudousquié, Klara Balint, Brian J. Stevenson, Philippe O. Gannon, Emanuela Marina Iancu, Laetitia Rossier, Silvia Martin Lluesma, Patrice Mathevet, Christine Sempoux, George Coukos, Urania Dafni, Alexandre Harari, Michal Bassani-Sternberg and Lana E. Kandalaft

    Citation: Journal of Translational Medicine 2019 17:391

    Content type: Protocol

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  24. Accumulated studies reported abnormal gene expression profiles of hepatocellular carcinoma (HCC) by cDNA microarray. We tried to merge cDNA microarray data from different studies to search for stably changed g...

    Authors: Yufeng Sun, Wenchao Li, Shiqi Shen, Xuejing Yang, Bing Lu, Xiaojing Zhang, Peng Lu, Yi Shen and Juling Ji

    Citation: Journal of Translational Medicine 2019 17:390

    Content type: Research

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  25. Conflicting evidence exists on the relationship between body mass index (BMI) and serum uric acid (SUA). Therefore, we aimed to evaluate the SUA–BMI relationship in a large-scale epidemiological survey in coas...

    Authors: Hui Zhou, Zhen Liu, Zhong Chao, Yeqing Chao, Lidan Ma, Xiaoyu Cheng, Yangang Wang, Changgui Li and Ying Chen

    Citation: Journal of Translational Medicine 2019 17:389

    Content type: Research

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  26. Cystic fibrosis (CF) is one of the most frequent genetic diseases and the median survival of these patients has improved in the last few decades, therefore it becomes necessary to evaluate the long-term compli...

    Authors: Silvia Lai, Sandro Mazzaferro, Anna Paola Mitterhofer, Enea Bonci, Paolo Giangreco Marotta, Francesco Pelligra, Manuel Murciano, Camilla Celani, Patrizia Troiani, Giuseppe Cimino and Paolo Palange

    Citation: Journal of Translational Medicine 2019 17:388

    Content type: Research

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  28. Clinical variables may correlate with lack of response to treatment (primary resistance) or clinical benefit in patients with clear cell renal cell carcinoma (ccRCC) treated with anti-programmed death 1/ligand...

    Authors: Brian W. Labadie, Ping Liu, Riyue Bao, Michael Crist, Ricardo Fernandes, Laura Ferreira, Scott Graupner, Andrew S. Poklepovic, Ignacio Duran, Saman Maleki Vareki, Arjun V. Balar and Jason J. Luke

    Citation: Journal of Translational Medicine 2019 17:386

    Content type: Research

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  29. Secondary and retrospective use of hospital-hosted clinical data provides a time- and cost-efficient alternative to prospective clinical trials for biomarker development. This study aims to create a retrospect...

    Authors: Rebecca J. Weiss, Sara V. Bates, Ya’nan Song, Yue Zhang, Emily M. Herzberg, Yih-Chieh Chen, Maryann Gong, Isabel Chien, Lily Zhang, Shawn N. Murphy, Randy L. Gollub, P. Ellen Grant and Yangming Ou

    Citation: Journal of Translational Medicine 2019 17:385

    Content type: Protocol

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  30. Alcohol withdrawal syndrome (AWS) is routinely treated with B-vitamins. However, the relationship between thiamine status and outcome is rarely examined. The aim of the present study was to examine the relatio...

    Authors: Donogh Maguire, Dinesh Talwar, Alana Burns, Anthony Catchpole, Fiona Stefanowicz, Gordon Robson, David P. Ross, David Young, Alastair Ireland, Ewan Forrest, Peter Galloway, Michael Adamson, Eoghan Colgan, Hannah Bell, Lesley Orr, Joanna-Lee Kerr…

    Citation: Journal of Translational Medicine 2019 17:384

    Content type: Research

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  31. Liver, as a vital organ, is responsible for a wide range of biological functions to maintain homeostasis and any type of damages to hepatic tissue contributes to disease progression and death. Viral infection,...

    Authors: Vahid Hosseini, Nazila Fathi Maroufi, Sepideh Saghati, Nahideh Asadi, Masoud Darabi, Saeed Nazari Soltan Ahmad, Hosseini Hosseinkhani and Reza Rahbarghazi

    Citation: Journal of Translational Medicine 2019 17:383

    Content type: Review

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  33. Bisphosphonate-induced osteonecrosis of the jaw (BRONJ) presents with a typical pattern of jaw necrosis in patients who have been prescribed bisphosphonates (BPs) and other antiangiogenetic drugs to treat oste...

    Authors: Kye Hwa Lee, Su-Hwan Kim, Chang Hyen Kim, Byung Joo Min, Grace Juyun Kim, Younggyun Lim, Hun-Sung Kim, Kang-Min Ahn and Ju Han Kim

    Citation: Journal of Translational Medicine 2019 17:381

    Content type: Research

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  34. Breast cancer is the most common malignancy in female patients worldwide. Because of its heterogeneity in terms of prognosis and therapeutic response, biomarkers with the potential to predict survival or assis...

    Authors: Xuanwen Bao, Natasa Anastasov, Yanfang Wang and Michael Rosemann

    Citation: Journal of Translational Medicine 2019 17:380

    Content type: Research

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  35. Cervical cancer is a common malignant carcinoma of the gynecological tract with high morbidity and mortality. Therefore, it is crucial to elucidate the pathogenesis, prevention, diagnosis and prognosis of cerv...

    Authors: Yue-Xin Hu, Ming-Jun Zheng, Wen-Chao Zhang, Xiao Li, Rui Gou, Xin Nie, Qing Liu, Ying-Ying Hao, Juan-Juan Liu and Bei Lin

    Citation: Journal of Translational Medicine 2019 17:379

    Content type: Research

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  36. When bone marrow is repeatedly filtered through porous material, the mesenchymal stem cells (MSCs) in the bone marrow can adhere to the outer and inner walls of the carrier material to become enriched locally,...

    Authors: Wenxiang Chu, Yifu Zhuang, Yaokai Gan, Xin Wang, Tingting Tang and Kerong Dai

    Citation: Journal of Translational Medicine 2019 17:377

    Content type: Research

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  37. Atherosclerosis preferentially develops in regions of disturbed flow (DF). Emerging evidence indicates that yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which are...

    Authors: Dandan Liu, Hang Lv, Qi Liu, Yanli Sun, Shenglong Hou, Lu Zhang, Mengyue Yang, Baihe Han, Gang wang, Xuedong Wang, Wenjuan Du, Honggang Nie, Ruoxi Zhang, Xingtao Huang, Jingbo Hou and Bo Yu

    Citation: Journal of Translational Medicine 2019 17:378

    Content type: Research

    Published on:

  38. Fatigue was reported as the most common any-grade adverse event (18.3%), and the most common grade 3 or higher immune-related adverse event (irAE) (0.89%) in patients receiving PD-1/PD-L1 checkpoint inhibitors...

    Authors: Alessio Cortellini, Maria G. Vitale, Federica De Galitiis, Francesca R. Di Pietro, Rossana Berardi, Mariangela Torniai, Michele De Tursi, Antonino Grassadonia, Pietro Di Marino, Daniele Santini, Tea Zeppola, Cecilia Anesi, Alain Gelibter, Mario Alberto Occhipinti, Andrea Botticelli, Paolo Marchetti…

    Citation: Journal of Translational Medicine 2019 17:376

    Content type: Research

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  39. Autologous tolerogenic dendritic cells (tolDC) are a promising therapeutic strategy for inflammatory arthritis (IA) as they can regulate autoantigen-specific T cell responses. Here, we investigated two outstan...

    Authors: Rachel Spiering, Manon A. A. Jansen, Matthew J. Wood, Anshorulloh A. Fath, Oliver Eltherington, Amy E. Anderson, Arthur G. Pratt, Willem van Eden, John D. Isaacs, Femke Broere and Catharien M. U. Hilkens

    Citation: Journal of Translational Medicine 2019 17:375

    Content type: Research

    Published on:

  40. Understanding cancer heterogeneity, its temporal evolution over time, and the outcomes of guided treatment depend on accurate data collection in a context of routine clinical care. We have developed a hospital...

    Authors: Grigory Sidorenkov, Janny Nagel, Coby Meijer, Jacko J. Duker, Harry J. M. Groen, Gyorgy B. Halmos, Maaike H. M. Oonk, Rene J. Oostergo, Bert van der Vegt, Max J. H. Witjes, Marcel Nijland, Klaas Havenga, John H. Maduro, Jourik A. Gietema and Gertruida H. de Bock

    Citation: Journal of Translational Medicine 2019 17:374

    Content type: Methodology

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  42. Treatment stratification based on bone marrow minimal residual disease (MRD) at set time points has resulted in considerably improved survival in pediatric acute lymphoblastic leukemia (ALL). Treatment respons...

    Authors: Andrea Rzepiel, Nóra Kutszegi, András Gézsi, Judit C. Sági, Bálint Egyed, György Péter, Henriett Butz, Gábor Nyírő, Judit Müller, Gábor T. Kovács, Csaba Szalai, Ágnes F. Semsei and Dániel J. Erdélyi

    Citation: Journal of Translational Medicine 2019 17:372

    Content type: Research

    Published on:

  43. The purification of peripheral blood mononuclear cells (PBMCs) by means of density gradient (1.07 g/mL) centrifugation is one of the most commonly used methods in diagnostics and research laboratories as well ...

    Authors: Luigi Coppola, Giovanni Smaldone, Alessandra Cianflone, Simona Baselice, Peppino Mirabelli and Marco Salvatore

    Citation: Journal of Translational Medicine 2019 17:371

    Content type: Methodology

    Published on:

  44. The purpose of the present work is to underline the importance of obtaining a standardized procedure to ensure and evaluate both clinical and research usability of human tissue samples. The study, which was ca...

    Authors: Margalida Esteva-Socias, María-Jesús Artiga, Olga Bahamonde, Oihana Belar, Raquel Bermudo, Erika Castro, Teresa Escámez, Máximo Fraga, Laura Jauregui-Mosquera, Isabel Novoa, Lorena Peiró-Chova, Juan-David Rejón, María Ruiz-Miró, Paula Vieiro-Balo, Virginia Villar-Campo, Sandra Zazo…

    Citation: Journal of Translational Medicine 2019 17:370

    Content type: Review

    Published on:

  45. Oxidized low density lipoprotein receptor 1 (OLR1), a type II membrane protein, has been identified as receptor for oxidized low-density lipoprotein. The current study firstly provided evidence that OLR1 regul...

    Authors: Long Jiang, Shanshan Jiang, Wenjie Zhou, Jia Huang, Yongbin Lin, Hao Long and Qingquan Luo

    Citation: Journal of Translational Medicine 2019 17:369

    Content type: Research

    Published on:

  46. Hypertension often presents with microvascular rarefaction (MVR), which is closely associated with impaired angiogenesis. Early detection of MVR is essential for systemic assessment in patient with hypertensio...

    Authors: Jianwen Liang, Yan Li, Long Chen, Wenhao Xia, Guifu Wu, Xinzhu Tong, Chen Su, Jiang He, Xiufang Lin and Jun Tao

    Citation: Journal of Translational Medicine 2019 17:368

    Content type: Research

    Published on:

  47. Stem cell therapy is investigated as a treatment option for patients with ischemic heart disease. In this study, long-term safety and efficacy of autologous intra-myocardial injections of adipose-derived strom...

    Authors: Abbas Ali Qayyum, Anders Bruun Mathiasen, Steffen Helqvist, Erik Jørgensen, Mandana Haack-Sørensen, Annette Ekblond and Jens Kastrup

    Citation: Journal of Translational Medicine 2019 17:360

    Content type: Research

    Published on:

  48. Proprotein convertase subtilisin/kexin 9 (PCSK9) has been proposed as a novel target for coronary artery disease (CAD). Familial hypercholesterolemia (FH) is characterized by high prevalence of CAD and major c...

    Authors: Ye-Xuan Cao, Jing-Lu Jin, Di Sun, Hui-Hui Liu, Yuan-Lin Guo, Na-Qiong Wu, Rui-Xia Xu, Cheng-Gang Zhu, Qian Dong, Jing Sun and Jian-Jun Li

    Citation: Journal of Translational Medicine 2019 17:367

    Content type: Research

    Published on:

  49. Myelodysplastic syndrome (MDS) can progress to acute myeloid leukemia (AML), and conventional chemotherapy (decitabine) does not effectively inhibit tumor cells. Enhancer of zeste homologue 2 (EZH2) and Heme o...

    Authors: Zhengchang He, Siyu Zhang, Dan Ma, Qin Fang, Liping Yang, Shaoxian Shen, Ying Chen, Lingli Ren and Jishi Wang

    Citation: Journal of Translational Medicine 2019 17:366

    Content type: Research

    Published on:

  50. There continues to be a great need for better biomarkers and host-directed treatment targets for community-acquired pneumonia (CAP). Alterations in phospholipid metabolism may constitute a source of small mole...

    Authors: Haroon Arshad, Juan Carlos López Alfonso, Raimo Franke, Katina Michaelis, Leonardo Araujo, Aamna Habib, Yuliya Zboromyrska, Eva Lücke, Emilia Strungaru, Manas K. Akmatov, Haralampos Hatzikirou, Michael Meyer-Hermann, Astrid Petersmann, Matthias Nauck, Mark Brönstrup, Ursula Bilitewski…

    Citation: Journal of Translational Medicine 2019 17:365

    Content type: Research

    Published on:

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