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  1. Content type: Research

    Glioma accounts for a large proportion of cancer, and an effective treatment for this disease is still lacking because of the absence of specific driver molecules. Current challenges in the treatment of glioma...

    Authors: Xiaonan Xi, Yahui Chu, Ning Liu, Qianqian Wang, Zheng Yin, Yaxin Lu and Yue Chen

    Citation: Journal of Translational Medicine 2019 17:129

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  2. Content type: Research

    Cell based therapies, such as bone marrow derived mesenchymal stem cells (BM-MSCs; also known as mesenchymal stromal cells), are currently under investigation for a number of disease applications. The current ...

    Authors: Alpa Trivedi, Byron Miyazawa, Stuart Gibb, Kristen Valanoski, Lindsay Vivona, Maximillian Lin, Daniel Potter, Mars Stone, Philip J. Norris, James Murphy, Sawyer Smith, Martin Schreiber and Shibani Pati

    Citation: Journal of Translational Medicine 2019 17:128

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  3. Content type: Research

    The sodium–glucose cotransporter-2 (SGLT2) inhibitor canagliflozin has been shown to reduce major cardiovascular events in type 2 diabetic patients, with a pronounced decrease in hospitalization for heart fail...

    Authors: Alex Ali Sayour, Sevil Korkmaz-Icöz, Sivakkanan Loganathan, Mihály Ruppert, Viktor Nabil Sayour, Attila Oláh, Kálmán Benke, Maik Brune, Rita Benkő, Eszter Mária Horváth, Matthias Karck, Béla Merkely, Tamás Radovits and Gábor Szabó

    Citation: Journal of Translational Medicine 2019 17:127

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  4. Content type: Research

    Esophageal cancer is the sixth-leading cause of cancer-related deaths worldwide. Cancer stem cells (CSCs) are the main reason for tumor relapse in esophageal squamous cell carcinoma (ESCC). The NOTCH pathway i...

    Authors: Meysam Moghbeli, Hooman Mosannen Mozaffari, Bahram Memar, Mohammad Mahdi Forghanifard, Mehran Gholamin and Mohammad Reza Abbaszadegan

    Citation: Journal of Translational Medicine 2019 17:126

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  5. Content type: Research

    While prostate cancer can often manifest as an indolent disease, the development of locally-advanced or metastatic disease can cause significant morbidity or mortality. Elucidation of molecular mechanisms cont...

    Authors: Aruz Mesci, Fabrice Lucien, Xiaoyong Huang, Eric H. Wang, David Shin, Michelle Meringer, Christianne Hoey, Jessica Ray, Paul C. Boutros, Hon S. Leong and Stanley K. Liu

    Citation: Journal of Translational Medicine 2019 17:125

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  6. Content type: Research

    Noninvasive prenatal screening (NIPS) based on cell-free fetal DNA (cffDNA) has rapidly been applied into clinic. However, the reliability of this method largely depends on the concentration of cffDNA in the m...

    Authors: Ping Hu, Dong Liang, Yangyi Chen, Ying Lin, Fengchang Qiao, Hang Li, Ting Wang, Chunfang Peng, Donghong Luo, Hailiang Liu and Zhengfeng Xu

    Citation: Journal of Translational Medicine 2019 17:124

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  7. Content type: Research

    Triple negative breast cancer (TNBC) has been classified as a disease subgroup defined by the lack of expression of estrogen and progesterone receptors as well as the absence of the human epidermal growth fact...

    Authors: Wijden Mahfoudh, Inchirah Bettaieb, Randa Ghedira, Kaouther Snoussi, Nadia Bouzid, Zahra Klayech, Sallouha Gabbouj, Yassmine Remadi, Elham Hassen, Noureddine Bouaouina and Abdelfateh Zakhama

    Citation: Journal of Translational Medicine 2019 17:123

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  8. Content type: Research

    Keto-analogues administration plays an important role in clinical chronic kidney disease (CKD) adjunctive therapy, however previous studies on their reno-protective effect mainly focused on kidney pathological...

    Authors: Meng Wang, Huzi Xu, Octavia Li-Sien Chong Lee Shin, Li Li, Hui Gao, Zhi Zhao, Fan Zhu, Han Zhu, Wangqun Liang, Kun Qian, Chunxiu Zhang, Rui Zeng, Hanjing Zhou and Ying Yao

    Citation: Journal of Translational Medicine 2019 17:122

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  9. Content type: Research

    Fibroblast growth factor 23 (FGF23) and endothelium-related biomarkers have been related to AKI in critically-ill patients. Also, FGF23 is associated with endothelial dysfunction. In this study, we investigate...

    Authors: Fernanda Macedo de Oliveira Neves, Camila Barbosa Araújo, Daniele Ferreira de Freitas, Bianca Fernandes Távora Arruda, Leonardo José Monteiro de Macêdo Filho, Vivian Brito Salles, Gdayllon Cavalcante Meneses, Alice Maria Costa Martins and Alexandre Braga Libório

    Citation: Journal of Translational Medicine 2019 17:121

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  10. Content type: Research

    Stereotactic ablative radiotherapy (SABR) shows a remarkable local control of non-small cell lung cancer (NSCLC) metastases, partially as a result of host immune status. However, the predictors of immune cells...

    Authors: Chao Liu, Qinyong Hu, Kai Hu, Huichao Su, Fang Shi, Li Kong, Hui Zhu and Jinming Yu

    Citation: Journal of Translational Medicine 2019 17:120

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  11. Content type: Research

    Urinary protein quantification is critical for assessing the severity of chronic kidney disease (CKD). However, the current procedure for determining the severity of CKD is completed through evaluating 24-h ur...

    Authors: Jing Xiao, Ruifeng Ding, Xiulin Xu, Haochen Guan, Xinhui Feng, Tao Sun, Sibo Zhu and Zhibin Ye

    Citation: Journal of Translational Medicine 2019 17:119

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  12. Content type: Research

    Targeting new molecular pathways leading to Osteoporosis (OP) and Osteoarthritis (OA) is a hot topic for drug discovery. Clusterin (CLU) is a glycoprotein involved in inflammation, proliferation, cell death, n...

    Authors: S. Pucci, C. Greggi, C. Polidoro, M. C. Piro, M. Celi, M. Feola, E. Gasbarra, R. Iundusi, F. Mastrangeli, G. Novelli, A. Orlandi and U. Tarantino

    Citation: Journal of Translational Medicine 2019 17:118

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  13. Content type: Research

    Extrahepatic metastasis is the independent risk factor of poor survival of primary hepatic carcinoma (PHC), and most occurs in the chest and abdomen. Currently, there is still no available method to predict th...

    Authors: Jia Hu, Ting Wang, Kun-He Zhang, Yi-Ping Jiang, Song Xu, Si-Hai Chen, Yu-Ting He, Hai-Liang Yuan and Yu-Qi Wang

    Citation: Journal of Translational Medicine 2019 17:117

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  14. Content type: Review

    Cancer is a serious health issue in the world due to a large body of cancer-related human deaths, and there is no current treatment available to efficiently treat the disease as the tumor is often diagnosed at...

    Authors: Yanyan Han

    Citation: Journal of Translational Medicine 2019 17:116

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  15. Content type: Research

    The number of Mesenchymal Stem/Stromal Cells (MSCs) in the human bone marrow (BM) is small compared to other cell types. BM aspirate concentration (BMAC) may be used to increase numbers of MSCs, but the compos...

    Authors: Richard Schäfer, Malcolm R. DeBaun, Erika Fleck, Christopher J. Centeno, Daniela Kraft, Johannes Leibacher, Karen Bieback, Erhard Seifried and Jason L. Dragoo

    Citation: Journal of Translational Medicine 2019 17:115

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  16. Content type: Research

    Various proinflammatory cytokines can be detected within the melanoma tumor microenvironment. Interleukin 32 (IL32) is produced by T cells, NK cells and monocytes/macrophages, but also by a subset of melanoma ...

    Authors: Helicia Paz, Jennifer Tsoi, Anusha Kalbasi, Catherine S. Grasso, William H. McBride, Dörthe Schaue, Lisa H. Butterfield, Deena M. Maurer, Antoni Ribas, Thomas G. Graeber and James S. Economou

    Citation: Journal of Translational Medicine 2019 17:113

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  17. Content type: Research

    Monoallelic expression (MAE) is a frequent genomic phenomenon in normal tissues, however its role in cancer is yet to be fully understood. MAE is defined as the expression of a gene that is restricted to one a...

    Authors: Lee Silcock, Hakeem Almabrazi, Younes Mokrab, Puthen Jithesh, Muna Al-Hashmi, Nicola James, Rebecca Mathew, Valentina Mattei, Davide Bedognetti, Francesca Lessi, Ramzi Temanni, Barbara Seliger, Rashid Al-Ali, Francesco M. Marincola, Ena Wang and Sara Tomei

    Citation: Journal of Translational Medicine 2019 17:112

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  18. Content type: Research

    A stroke caused by angiostenosis always has a poor prognosis. Bone marrow stromal cells (BMSC) are widely applied in vascular regeneration. Recently, thrombospondin-4 (TSP4) was reported to promote the regener...

    Authors: Qian Zhang, Meiling Zhou, Xiangfeng Wu, Zhu Li, Bing Liu, Wenbin Gao, Jin Yue and Tao Liu

    Citation: Journal of Translational Medicine 2019 17:111

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  19. Content type: Research

    Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in humans, and ranges from steatosis to non-alcoholic steatohepatitis (NASH), the latter with risk of progression to cirrhosis. The Gö...

    Authors: Camilla Schumacher-Petersen, Berit Østergaard Christoffersen, Rikke Kaae Kirk, Trine Pagh Ludvigsen, Nora Elisabeth Zois, Henrik Duelund Pedersen, Mogens Vyberg and Lisbeth Høier Olsen

    Citation: Journal of Translational Medicine 2019 17:110

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  20. Content type: Research

    The dynein axonemal heavy chain (DNAH) family of genes encode the dynein axonemal heavy chain, which is involved in cell motility. Genomic variations of DNAH family members have been frequently reported in div...

    Authors: Chunchao Zhu, Qin Yang, Jia Xu, Wenyi Zhao, Zizhen Zhang, Danhua Xu, Yeqian Zhang, Enhao Zhao and Gang Zhao

    Citation: Journal of Translational Medicine 2019 17:109

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  21. Content type: Research

    Previous studies have shown that zinc-finger CCHC-type containing 13 (ZCCHC13) is located in an imprinted gene cluster in the X-inactivation centre, but few published studies have provided evidence of its expr...

    Authors: Zhiming Li, Zhi Li, Linjun Wang, Chen Long, Zaozao Zheng and Xuan Zhuang

    Citation: Journal of Translational Medicine 2019 17:108

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  22. Content type: Research

    Chronic low-grade inflammation and oxidative stress play important roles in the development of obesity-induced cardiac hypertrophy. Here, we investigated the role of Fibronectin type III domain containing 5 (F...

    Authors: Zhi Geng, Wen-Yong Fan, Bing Zhou, Chao Ye, Ying Tong, Ye-Bo Zhou and Xiao-Qing Xiong

    Citation: Journal of Translational Medicine 2019 17:107

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  23. Content type: Research

    Acute myeloid leukemia (AML) is a highly heterogeneous malignancy with various outcomes, and therefore needs better risk stratification tools to help select optimal therapeutic options.

    Authors: Huihui Zhang, Ninghan Zhang, Rong Wang, Tingting Shao, Yuan Feng, Yao Yao, Qingyun Wu, Shengyun Zhu, Jiang Cao, Huanxin Zhang, Zhenyu Li, Xuejiao Liu, Mingshan Niu and Kailin Xu

    Citation: Journal of Translational Medicine 2019 17:106

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  24. Content type: Research

    With increasing number of breast cancer survivors, more attention is drawn to long-term consequences of curative cancer treatment. Adjuvant treatment of breast cancer patients is associated with several unfavo...

    Authors: Stine Overvad Fredslund, Claus Højbjerg Gravholt, Britt Elmedal Laursen and Anders Bonde Jensen

    Citation: Journal of Translational Medicine 2019 17:105

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  25. Content type: Research

    Bone marrow-derived stem cells (BMSCs) and chondrocytes have been reported to present “dedifferentiation” and “phenotypic loss” during the chondrogenic differentiation process in cartilage tissue engineering, ...

    Authors: Ke Xue, Xiaodie Zhang, Zixu Gao, Wanyao Xia, Lin Qi and Kai Liu

    Citation: Journal of Translational Medicine 2019 17:104

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  26. Content type: Research

    Heparanase (HPSE) is an endo-beta-glucuronidase that degrades heparan sulfate (HS) chains on proteoglycans. The oligosaccharides generated by HPSE promote angiogenesis, tumor growth and metastasis. Heparanase-...

    Authors: Thérèse Rachell Theodoro, Leandro Luongo Matos, Renan Pelluzzi Cavalheiro, Giselle Zenker Justo, Helena Bonciani Nader and Maria Aparecida Silva Pinhal

    Citation: Journal of Translational Medicine 2019 17:103

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  27. Content type: Research

    Leukemia stem cell (LSC)-enriched genes have been shown to be highly prognostic in acute myeloid leukemia (AML). However, the prognostic value of tumor suppressor genes (TSGs) that are repressed early in LSC r...

    Authors: Zi-jun Xu, Ji-chun Ma, Jing-dong Zhou, Xiang-mei Wen, Dong-ming Yao, Wei Zhang, Run-bi Ji, De-hong Wu, Li-juan Tang, Zhao-qun Deng, Jun Qian and Jiang Lin

    Citation: Journal of Translational Medicine 2019 17:102

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  28. Content type: Research

    SETD2, the single mediator of trimethylation of histone 3 at position lysine 36, has been reported associated with initiation progression and chemotherapy resistance in acute myeloid leukemia (AML). Whether polym...

    Authors: Suwei Wang, Xiaoqing Yuan, Yazhen Liu, Kewei Zhu, Peng Chen, Han Yan, Daoyu Zhang, Xi Li, Hui Zeng, Xielan Zhao, Xiaoping Chen, Gan Zhou and Shan Cao

    Citation: Journal of Translational Medicine 2019 17:101

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  29. Content type: Research

    Previous studies have identified IFNγ as an important early barrier to oncolytic viruses including vaccinia. The existing innate and adaptive immune barriers restricting oncolytic virotherapy, however, can be ...

    Authors: Dobrin D. Draganov, Antonio F. Santidrian, Ivelina Minev, Duong Nguyen, Mehmet Okyay Kilinc, Ivan Petrov, Anna Vyalkova, Elliot Lander, Mark Berman, Boris Minev and Aladar A. Szalay

    Citation: Journal of Translational Medicine 2019 17:100

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  30. Content type: Research

    The advent of immune checkpoint inhibitors (ICIs) has considerably expanded the armamentarium against non-small cell lung cancer (NSCLC) contributing to reshaping treatment paradigms in the advanced disease se...

    Authors: Andrea Botticelli, Massimiliano Salati, Francesca Romana Di Pietro, Lidia Strigari, Bruna Cerbelli, Ilaria Grazia Zizzari, Raffaele Giusti, Marco Mazzotta, Federica Mazzuca, Michela Roberto, Patrizia Vici, Laura Pizzuti, Marianna Nuti and Paolo Marchetti

    Citation: Journal of Translational Medicine 2019 17:99

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  31. Content type: Research

    OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic...

    Authors: Kurt D. Ristroph, Jie Feng, Simon A. McManus, Yingyue Zhang, Kai Gong, Hanu Ramachandruni, Claire E. White and Robert K. Prud’homme

    Citation: Journal of Translational Medicine 2019 17:97

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  32. Content type: Research

    Molecularly targeted therapies using receptor inhibitors, small molecules or monoclonal antibodies are routinely applied in oncology. Verification of target expression should be mandatory prior to initiation o...

    Authors: Niklas Schäfer, Gerrit H. Gielen, Laurèl Rauschenbach, Sied Kebir, Andreas Till, Roman Reinartz, Matthias Simon, Pitt Niehusmann, Christoph Kleinschnitz, Ulrich Herrlinger, Torsten Pietsch, Björn Scheffler and Martin Glas

    Citation: Journal of Translational Medicine 2019 17:96

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  33. Content type: Research

    Oxidized low-density lipoproteins and scavenger receptors (SRs) play an important role in the formation and development of atherosclerotic plaques. However, little is known about their presence in epicardial a...

    Authors: Concepción Santiago-Fernández, Luis M. Pérez-Belmonte, Mercedes Millán-Gómez, Inmaculada Moreno-Santos, Fernando Carrasco-Chinchilla, Amalio Ruiz-Salas, Luis Morcillo-Hidalgo, José M. Melero, Lourdes Garrido-Sánchez and Manuel Jiménez-Navarro

    Citation: Journal of Translational Medicine 2019 17:95

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  34. Content type: Research

    Chronic hepatitis C virus (HCV)-infection is a slowly debilitating and potentially fatal disease with a high estimated number of undiagnosed cases. Given the major advances in the treatment, detection of unrep...

    Authors: Markus Reiser, Bianka Wiebner and Jürgen Hirsch

    Citation: Journal of Translational Medicine 2019 17:94

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  35. Content type: Research

    Prostaglandin E receptor 2 (EP2) is an immune modulatory molecule that regulates the balance of immunity. Here we investigated the role of EP2 in immune dysregulation in patients with acute-on-chronic liver fa...

    Authors: Yunyun Wang, Chao Chen, Jinjin Qi, Fengtian Wu, Jun Guan, Zhi Chen and Haihong Zhu

    Citation: Journal of Translational Medicine 2019 17:93

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  36. Content type: Research

    Identifying intestinal node-negative gastric adenocarcinoma (INGA) patients with high risk of recurrence could help perceive benefit of adjuvant therapy for INGA patients following surgical resection. This stu...

    Authors: Meng-Yao Ji, Lei Yuan, Xiao-Da Jiang, Zhi Zeng, Na Zhan, Ping-Xiao Huang, Cheng Lu and Wei-Guo Dong

    Citation: Journal of Translational Medicine 2019 17:92

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  37. Content type: Research

    Hyperoxia-induced bronchopulmonary dysplasia (BPD) models are essential for better understanding and impacting on long-term pulmonary, cardiovascular, and neurological sequelae of this chronic disease. Only fe...

    Authors: Francesco Greco, Susanne Wiegert, Philipp Baumann, Sven Wellmann, Giovanni Pellegrini and Vincenzo Cannizzaro

    Citation: Journal of Translational Medicine 2019 17:91

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  38. Content type: Research

    Hypercoagulation and neutrophilia are described in several cancers, however, whether they are involved in lung carcinogenesis is currently unknown. Emodin is the main bioactive component from Rheum palmatum an...

    Authors: Zibo Li, Yukun Lin, Shuhui Zhang, Lin Zhou, Guixi Yan, Yuehua Wang, Mengdi Zhang, Mengqi Wang, Haihong Lin, Qiaozhen Tong, Yongjian Duan and Gangjun Du

    Citation: Journal of Translational Medicine 2019 17:90

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  39. Content type: Research

    Artificial meniscal implants can be used to replace a severely injured meniscus after meniscectomy and restore the normal functionality of a knee joint. The aim of this paper was to design porous meniscal impl...

    Authors: Li-ya Zhu, Lan Li, Zong-an Li, Jian-ping Shi, Wen-lai Tang, Ji-quan Yang and Qing Jiang

    Citation: Journal of Translational Medicine 2019 17:89

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  40. Content type: Research

    Excess dietary sodium is not only excreted by the kidneys, but can also be stored by non-osmotic binding with glycosaminoglycans in dermal connective tissue. Such storage has been associated with dermal inflam...

    Authors: Ryanne S. Hijmans, Marco van Londen, Kwaku A. Sarpong, Stephan J. L. Bakker, Gerjan J. Navis, Twan T. R. Storteboom, Wilhelmina H. A. de Jong, Robert A. Pol and Jacob van den Born

    Citation: Journal of Translational Medicine 2019 17:88

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  41. Content type: Review

    Human growth is a complex mechanism that depends on genetic, environmental, nutritional and hormonal factors. The main hormone involved in growth at each stage of development is growth hormone (GH) and its med...

    Authors: Susanna Esposito, Alberto Leonardi, Lucia Lanciotti, Marta Cofini, Giulia Muzi and Laura Penta

    Citation: Journal of Translational Medicine 2019 17:87

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  42. Content type: Research

    Chronic kidney disease (CKD) leads to end-stage renal failure and cardiovascular events. An attribute to these progressions is abnormalities in inflammation, which can be evaluated using the neutrophil-to-lymp...

    Authors: Qiongjing Yuan, Jinwei Wang, Zhangzhe Peng, Qiaoling Zhou, Xiangcheng Xiao, Yanyun Xie, Wei Wang, Ling Huang, Wenbin Tang, Danni Sun, Luxia Zhang, Fang Wang, Ming-Hui Zhao, Lijian Tao, Kevin He and Hui Xu

    Citation: Journal of Translational Medicine 2019 17:86

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  43. Content type: Research

    Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease characterized by upregulation of inflammatory cell death and osteoclastogenesis. Necrostatin (NST)-1s is a chemical inhibitor of recepto...

    Authors: Jooyeon Jhun, Seung Hoon Lee, Se-Young Kim, Jaeyoon Ryu, Ji Ye Kwon, Hyun Sik Na, KyoungAh Jung, Su-Jin Moon, Mi-La Cho and Jun-Ki Min

    Citation: Journal of Translational Medicine 2019 17:84

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  44. Content type: Correction

    Following publication of the original article [1], the authors reported updated affiliations for five of the authors. The updated affiliations are shown below and reflected in the affiliation list of this Corr...

    Authors: C. Tersigni, S. D’Ippolito, F. Di Nicuolo, R. Marana, V. Valenza, V. Masciullo, F. Scaldaferri, F. Malatacca, C. de Waure, A. Gasbarrini, G. Scambia and N. Di Simone

    Citation: Journal of Translational Medicine 2019 17:83

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    The original article was published in Journal of Translational Medicine 2018 16:102

  45. Content type: Research

    Therapeutic plasma exchange (PE) or plasmapheresis is an extracorporeal procedure employed to treat immunological disorders. Exosomes, nanosized vesicles of endosomal origin, mediate intercellular communicatio...

    Authors: Sujay Ramanathan, Sabrina R. Douglas, Guillermo M. Alexander, Botros B. Shenoda, James E. Barrett, Enrique Aradillas, Ahmet Sacan and Seena K. Ajit

    Citation: Journal of Translational Medicine 2019 17:81

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  46. Content type: Research

    There are no known objective biomarkers to assist with the diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A small number of studies have shown that ME/CFS patients exhibit an earlier...

    Authors: Maximillian J. Nelson, Jonathan D. Buckley, Rebecca L. Thomson, Daniel Clark, Richard Kwiatek and Kade Davison

    Citation: Journal of Translational Medicine 2019 17:80

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