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Research
Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor protein that functions as a potential tumor suppressor, and SPOP mutations have been identified in ~10% of human prostate cancers. However, it ...
Journal of Translational Medicine 2017 15:175
Published on: 15 August 2017
Research
Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide owing to its high rates of metastasis and recurrence. The oncogene IQ motif-containing GTPase activating protein 3 (IQGAP3) is ubiquitous...
Journal of Translational Medicine 2017 15:176
Published on: 15 August 2017
Research
Red blood cell (RBC) depletion is a standard graft manipulation technique for ABO-incompatible bone marrow (BM) transplants. The BM processing module for Spectra Optia, “BMC”, was previously introduced. We her...
Journal of Translational Medicine 2017 15:174
Published on: 11 August 2017
Commentary
Anti-programmed death (PD)-1 and PD-ligand (L)-1 checkpoint inhibitors have revolutionized the therapy of several cancers. Immunotherapy of cancer can offer long-term durable benefit to patients, is active reg...
Journal of Translational Medicine 2017 15:173
Published on: 8 August 2017
Research
It is now recognized that asthma can present in different forms. Typically, asthma present with symptoms of wheeze, breathlessness and cough. Atypical forms of asthma such as cough variant asthma (CVA) or che...
Journal of Translational Medicine 2017 15:171
Published on: 4 August 2017
Research
To assess whether circadian patterns of temperature correlate with further values of intracranial pressure (ICP) in severe brain injury treated with hypothermia.
Journal of Translational Medicine 2017 15:170
Published on: 3 August 2017
Research
In humans, the heterochronic cascade composed of the RNA-binding protein LIN28 and its major target, the let-7 family of microRNAs (miRNAs), is highly regulated during human erythroid ontogeny. Additionally, down...
Journal of Translational Medicine 2017 15:169
Published on: 2 August 2017
Research
Squamous cell carcinoma of the head and neck (HNSCC) represents an array of disease processes with a generally unfavorable prognosis. Inflammation plays an important role in tumor development and response to t...
Journal of Translational Medicine 2017 15:168
Published on: 2 August 2017
Research
The purpose of this study was to explore gene copy number (GCN) variation of EGFR, HER2, c-MYC, and MET in patients with primary colorectal cancer (CRC).
Journal of Translational Medicine 2017 15:167
Published on: 1 August 2017
Research
This study aimed to establish a model that estimates the survival advantage at the molecular level based on telomere length and serum biomarkers of aging, to explore clinical significance.
Journal of Translational Medicine 2017 15:166
Published on: 1 August 2017
Review
Cardiovascular disease remains a major health care challenge. The knowledge about the underlying mechanisms of the respective vascular disease etiologies has greatly expanded over the last decades. This includ...
Journal of Translational Medicine 2017 15:164
Published on: 28 July 2017
Research
Co-circulation of influenza strains is common to seasonal epidemics and pandemic emergence. Competition was considered involved in the vicissitudes of co-circulating influenza strains but never quantitatively ...
Journal of Translational Medicine 2017 15:163
Published on: 28 July 2017
Research
The coiled-coil domain is a structural motif found in proteins that participate in a variety of biological processes. Aberrant expression of such proteins has been shown to be associated with the malignant beh...
Journal of Translational Medicine 2017 15:165
Published on: 28 July 2017
Review
Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a common and severe disease with a considerable social and economic impact. So far, the etiology is not known, and neither a diagnostic marker ...
Journal of Translational Medicine 2017 15:162
Published on: 26 July 2017
Research
In an attempt to increase the therapeutic potential for myocardial regeneration, there is a quest for new cell sources and types for cell therapy protocols. The pathophysiology of heart diseases may affect cel...
Journal of Translational Medicine 2017 15:161
Published on: 25 July 2017
Review
Most modern societies undergo rapid population aging. The rise in life expectancy, nevertheless, is not accompanied, to date, by the same increment of healthspan. Efforts to increase healthspan by means of sup...
Journal of Translational Medicine 2017 15:160
Published on: 20 July 2017
Research
Changes in glucose and energy metabolism contribute to the altered phenotype of cancer cells and are the basis for positron emission tomography with 18F-fluoro-2-deoxy-d-glucose (FDG) to visualize tumors in vivo....
Journal of Translational Medicine 2017 15:158
Published on: 19 July 2017
Research
ETS2 is a downstream effector of the RAS/RAF/ERK pathway, which plays a critical role in the development of malignant tumor. However, the clinical impact of ETS2 expression in AML rema...
Journal of Translational Medicine 2017 15:159
Published on: 19 July 2017
Erratum
Journal of Translational Medicine 2017 15:157
Published on: 18 July 2017
The original article was published in Journal of Translational Medicine 2016 14:121
Research
MicroRNAs (miRNAs) are a class of regulatory RNAs that regulate gene expression post-transcriptionally. Little, however, is known on the expression profile of circulating miRNAs in Tetralogy of Fallot (TOF) pa...
Journal of Translational Medicine 2017 15:156
Published on: 10 July 2017
Research
Changes in adaptive immune cells after chemotherapy in adult acute myeloid leukemia (AML) may have implications for the success of immunotherapy. This study was designed to determine the functional capacity of...
Journal of Translational Medicine 2017 15:155
Published on: 10 July 2017
Research
The success of immunotherapeutics in oncology and the search for further improvements has prompted revisiting the use of cancer vaccines. In this context, knowledge of the immunogenic epitopes and the monitori...
Journal of Translational Medicine 2017 15:154
Published on: 5 July 2017
Research
Dendritic cells (DC) and tumour-associated macrophages (TAM) are essential in linking the innate and adaptive immune response against tumour cells and tumour progression. These cells are also potential target ...
Journal of Translational Medicine 2017 15:152
Published on: 3 July 2017
Protocol
Regular physical activity is recommended for patients with chronic heart failure to improve their functional capacity, and walking is a popular, effective, and safe form of physical activity. Pedometers have s...
Journal of Translational Medicine 2017 15:153
Published on: 3 July 2017
Review
Thanks to striking progress in both the understanding of anti-tumor immune response and the characterization of several tumor associated antigens (TAA), a more rational design and more sophisticated strategies...
Journal of Translational Medicine 2017 15:151
Published on: 1 July 2017
