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  1. Content type: Research

    World Trade Center (WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. New York University (NYU) and Mount Sinai have recreated WTC exposure in rodents to observe the resulting ...

    Authors: Wil Lieberman-Cribbin, Stephanie Tuminello, Christina Gillezeau, Maaike van Gerwen, Rachel Brody, David J. Mulholland, Lori Horton, Maureen Sisco, Colette Prophete, Judith Zelikoff, Hyun-Wook Lee, Sung-Hyun Park, Lung-Chi Chen, Mitchell D. Cohen and Emanuela Taioli

    Citation: Journal of Translational Medicine 2019 17:342

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  2. Content type: Research

    The role of body fat distribution in uric acid metabolism is still ambiguity. We aimed to investigate the independent contribution of visceral adipose measured by visceral adiposity index and lipid accumulatio...

    Authors: Xiaolin Huang, Xiaohong Jiang, Long Wang, Lu Chen, Yang Wu, Pei Gao and Fei Hua

    Citation: Journal of Translational Medicine 2019 17:341

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  3. Content type: Research

    Pemetrexed combined with platinum complexes can be used as first-line treatment for advanced non-squamous non-small cell lung cancer (NSCLC), however, the efficacy and safety is varying from individuals. There...

    Authors: Xiaohong Han, Ying Han, Qiaoyun Tan, Yu Huang, Jianliang Yang, Sheng Yang, Xiaohui He, Shengyu Zhou, Yan Song, Jinping Pi, Lijie Zuo, Jiarui Yao, Di Wu, Zhishang Zhang and Yuankai Shi

    Citation: Journal of Translational Medicine 2019 17:339

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  4. Content type: Research

    At present, immune checkpoint inhibitors, such as pembrolizumab, are widely used in the therapy of advanced non-resectable melanoma, as they induce more durable responses than other available treatments. Howev...

    Authors: Neta Tsur, Yuri Kogan, Evgenia Avizov-Khodak, Désirée Vaeth, Nils Vogler, Jochen Utikal, Michal Lotem and Zvia Agur

    Citation: Journal of Translational Medicine 2019 17:338

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  5. Content type: Review

    Genomic and radiomic data integration, namely radiogenomics, can provide meaningful knowledge in cancer diagnosis, prognosis and treatment. Despite several data structures based on multi-layer architecture pro...

    Authors: Mario Zanfardino, Monica Franzese, Katia Pane, Carlo Cavaliere, Serena Monti, Giuseppina Esposito, Marco Salvatore and Marco Aiello

    Citation: Journal of Translational Medicine 2019 17:337

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  6. Content type: Research

    The P38 mitogen-activated protein kinase (MAPK) pathway plays an essential role in CVB3-induced diseases. We previously demonstrated microRNA-21 has potential inhibitory effect on the MAP2K3 which locates upst...

    Authors: Feng He, Zonghui Xiao, Hailan Yao, Sen Li, Miao Feng, Wei Wang, Zhewei Liu, Zhuo Liu and Jianxin Wu

    Citation: Journal of Translational Medicine 2019 17:335

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  7. Content type: Research

    MicroRNAs (miRNAs) are promising biomarkers due to their structural stability and distinct expression profile in various cancers. We wanted to explore the miRNA expression in benign breast tissue and breast ca...

    Authors: Line Moi, Tonje Braaten, Khalid Al-Shibli, Eiliv Lund and Lill-Tove Rasmussen Busund

    Citation: Journal of Translational Medicine 2019 17:334

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  8. Content type: Research

    In colorectal cancer surgery there is a delicate balance between complete removal of the tumor and sparing as much healthy tissue as possible. Especially in rectal cancer, intraoperative tissue recognition cou...

    Authors: E. J. M. Baltussen, S. G. Brouwer de Koning, J. Sanders, A. G. J. Aalbers, N. F. M. Kok, G. L. Beets, B. H. W. Hendriks, H. J. C. M. Sterenborg, K. F. D. Kuhlmann and T. J. M. Ruers

    Citation: Journal of Translational Medicine 2019 17:333

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  9. Content type: Research

    It has been established that children with Autism Spectrum Disorders (ASD) are affected by oxidative stress, the origin of which is still under investigation. In the present work, we evaluated inflammatory and...

    Authors: P. M. Abruzzo, A. Matté, A. Bolotta, E. Federti, A. Ghezzo, T. Guarnieri, M. Marini, A. Posar, A. Siciliano, L. De Franceschi and P. Visconti

    Citation: Journal of Translational Medicine 2019 17:332

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  10. Content type: Research

    Brain metastases (BM) are the most common intracranial tumors. 2–14% of BM patients present with unknown primary site despite intensive evaluations. This study aims to evaluate the performance of a 90-gene exp...

    Authors: Yulong Zheng, Yongfeng Ding, Qifeng Wang, Yifeng Sun, Xiaodong Teng, Qiqi Gao, Weixiang Zhong, Xiaofeng Lou, Cheng Xiao, Chengshu Chen, Qinghua Xu and Nong Xu

    Citation: Journal of Translational Medicine 2019 17:331

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  11. Content type: Research

    Best vitelliform macular dystrophy (BVMD) is an autosomal dominant macular degeneration. The typical central yellowish yolk-like lesion usually appears in childhood and gradually worsens. Most cases are caused...

    Authors: Vladimir Frecer, Giancarlo Iarossi, Anna Paola Salvetti, Paolo Enrico Maltese, Giulia Delledonne, Marta Oldani, Giovanni Staurenghi, Benedetto Falsini, Angelo Maria Minnella, Lucia Ziccardi, Adriano Magli, Leonardo Colombo, Fabiana D’Esposito, Jan Miertus, Francesco Viola, Marcella Attanasio…

    Citation: Journal of Translational Medicine 2019 17:330

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  12. Content type: Research

    Acute traumatic cervical spinal cord injury (SCI) is a leading cause of disability in adolescents and young adults worldwide. Evidence from previous studies suggests that circulating cell-free DNA is associate...

    Authors: Hung-Chen Wang, Yu-Tsai Lin, Shih-Yuan Hsu, Nai-Wen Tsai, Yun-Ru Lai, Ben Yu-Jih Su, Chia-Te Kung and Cheng-Hsien Lu

    Citation: Journal of Translational Medicine 2019 17:329

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  13. Content type: Research

    Liquid biopsy based on cell-free DNA circulating in plasma has shown solid results as a non-invasive biomarker. In the present study we evaluated the utility of circulating free DNA (cfDNA) and the sub-type tu...

    Authors: Marianna Alunni-Fabbroni, Kerstin Rönsch, Thomas Huber, Clemens C. Cyran, Max Seidensticker, Julia Mayerle, Maciej Pech, Bristi Basu, Chris Verslype, Julia Benckert, Peter Malfertheiner and Jens Ricke

    Citation: Journal of Translational Medicine 2019 17:328

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  14. Content type: Research

    Oxidative stress has a determinantal effect on human dental pulp stromal cells (hDPSCs), including affecting their longevity and functionality. Circular RNAs (circRNAs) play an essential role in stromal cell b...

    Authors: Jingying Zhang, Dan Li, Dan Wang, Kenny Man and Xuebin Yang

    Citation: Journal of Translational Medicine 2019 17:327

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  15. Content type: Research

    To develop a machine learning model for predicting acute respiratory distress syndrome (ARDS) events through commonly available parameters, including baseline characteristics and clinical and laboratory parame...

    Authors: Xian-Fei Ding, Jin-Bo Li, Huo-Yan Liang, Zong-Yu Wang, Ting-Ting Jiao, Zhuang Liu, Liang Yi, Wei-Shuai Bian, Shu-Peng Wang, Xi Zhu and Tong-Wen Sun

    Citation: Journal of Translational Medicine 2019 17:326

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  16. Content type: Research

    Breastfeeding is the ideal source of infant nutrition. Human milk consists not only of nutrients but also biologically active components. Among these latter compounds, exosomes contain proteins, lipids, mRNAs ...

    Authors: Shimon Reif, Yaffa Elbaum Shiff and Regina Golan-Gerstl

    Citation: Journal of Translational Medicine 2019 17:325

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  17. Content type: Research

    DNA methylation can regulate the role of long noncoding RNAs (lncRNAs) in the development of lung adenocarcinoma (LUAD). The present study aimed to identify methylation-driven lncRNAs and mRNAs as biomarkers i...

    Authors: Rui Li, Yi-E Yang, Yun-Hong Yin, Meng-Yu Zhang, Hao Li and Yi-Qing Qu

    Citation: Journal of Translational Medicine 2019 17:324

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  18. Content type: Research

    To investigate the association of serum levels of 25(OH)D and 1,25(OH)2D3 in healthy and non-healthy controls with Crohn’s disease (CD) and ulcerative colitis (UC).

    Authors: Xi-Xi Li, Yang Liu, Jie Luo, Zhen-Dong Huang, Chao Zhang and Yan Fu

    Citation: Journal of Translational Medicine 2019 17:323

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  19. Content type: Research

    Recently, numerous biological experiments have indicated that microRNAs (miRNAs) play critical roles in exploring the pathogenesis of various human diseases. Since traditional experimental methods for miRNA-di...

    Authors: Guobo Xie, Zhiliang Fan, Yuping Sun, Cuiming Wu and Lei Ma

    Citation: Journal of Translational Medicine 2019 17:322

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  20. Content type: Research

    Medulloblastoma (MB), the most common pediatric brain cancer, presents with a poor prognosis in a subset of patients with high risk disease, or at recurrence, where current therapies are ineffective. Cord bloo...

    Authors: Allison B. Powell, Sridevi Yadavilli, Devin Saunders, Stacey Van Pelt, Elizabeth Chorvinsky, Rachel A. Burga, Shuroug Albihani, Patrick J. Hanley, Zhenhua Xu, Yanxin Pei, Eric S. Yvon, Eugene I. Hwang, Catherine M. Bollard, Javad Nazarian and Conrad Russell Y. Cruz

    Citation: Journal of Translational Medicine 2019 17:321

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  21. Content type: Research

    Immunoglobulin A nephropathy (IgAN) is the leading cause of end-stage kidney disease. Previous mRNA microarray profiling studies of IgAN revealed inconsistent data. We sought to identify the aberrantly express...

    Authors: Youxia Liu, Xiangchun Liu, Junya Jia, Jie Zheng and Tiekun Yan

    Citation: Journal of Translational Medicine 2019 17:320

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  22. Content type: Review

    Post-transcriptional modifications have been recently expanded with the addition of RNA editing, which is predominantly mediated by adenosine and cytidine deaminases acting on DNA and RNA. Here, we review the ...

    Authors: Theodoulakis Christofi and Apostolos Zaravinos

    Citation: Journal of Translational Medicine 2019 17:319

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  23. Content type: Research

    Only few studies, with small patient cohorts, have evaluated the effect of radiotherapy (RT) for metaplastic breast cancer (MBC). Hence, it is important to investigate the role of RT in MBC survival using a la...

    Authors: Yongfeng Li, Meng Chen, Barbara Pardini, Mihnea P. Dragomir, Anthony Lucci and George A. Calin

    Citation: Journal of Translational Medicine 2019 17:318

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  24. Content type: Research

    Infertility has become a global health issue with the number of couples seeking in vitro fertilization (IVF) worldwide continuing to rise. Some couples remain childless after several IVF cycles. Women undergoi...

    Authors: Jiahui Qiu, Pingping Li, Meng Dong, Xing Xin and Jichun Tan

    Citation: Journal of Translational Medicine 2019 17:317

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  25. Content type: Research

    Advances in microRNAs (miRNAs) biomarkers have generated disease markers with potential clinical values. However, none of these published results have been applied in clinic until today. The main reason could ...

    Authors: Yanqin Niu, Sijian Xia, Mingyang Su, Quanjin Dang, Kang Kang, Li Li and Deming Gou

    Citation: Journal of Translational Medicine 2019 17:316

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  26. Content type: Correction

    Following publication of the original article [1], the authors reported that one of the authors, Corrado Caracò, has been accidentally omitted from the author list. In this Correction the author has been added...

    Authors: Paolo Antonio Ascierto, Lorenzo Borgognoni, Gerardo Botti, Michele Guida, Paolo Marchetti, Simone Mocellin, Paolo Muto, Giuseppe Palmieri, Roberto Patuzzo, Pietro Quaglino, Ignazio Stanganelli and Corrado Caracò

    Citation: Journal of Translational Medicine 2019 17:315

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    The original article was published in Journal of Translational Medicine 2019 17:266

  27. Content type: Methodology

    Wearable smart watches provide large amount of real-time data on the environmental state of the users and are useful to determine risk factors for onset and progression of myopia. We aim to evaluate the effica...

    Authors: Bin Ye, Kangping Liu, Siting Cao, Padmaja Sankaridurg, Wayne Li, Mengli Luan, Bo Zhang, Jianfeng Zhu, Haidong Zou, Xun Xu and Xiangui He

    Citation: Journal of Translational Medicine 2019 17:314

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  28. Content type: Research

    This study was conducted to investigate whether the daily consumption of haem, non-haem, total iron and red meat can affect the occurrence of metabolic syndrome (MetS) and its components.

    Authors: Zohre Esfandiar, Firoozeh Hosseini-Esfahani, Parvin Mirmiran, Ali-Siamak Habibi-Moeini and Fereidoun Azizi

    Citation: Journal of Translational Medicine 2019 17:313

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  29. Content type: Research

    Despite major advances in rheumatoid arthritis outcome, not all patients achieve remission, and there is still an unmet need for new therapeutic approaches. This study aimed at evaluating in a pre-clinical mur...

    Authors: Céline Coppard, Francis Bonnefoy, Dalil Hannani, Françoise Gabert, Olivier Manches, Joel Plumas, Sylvain Perruche and Laurence Chaperot

    Citation: Journal of Translational Medicine 2019 17:312

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  30. Content type: Research

    Prostate cancer (PCa) remains the second leading cause of deaths due to cancer in the United States in men. The aim of this study was to perform an integrative epigenetic analysis of prostate adenocarcinoma to...

    Authors: Ning Xu, Yu-Peng Wu, Zhi-Bin Ke, Ying-Chun Liang, Hai Cai, Wen-Ting Su, Xuan Tao, Shao-Hao Chen, Qing-Shui Zheng, Yong Wei and Xue-Yi Xue

    Citation: Journal of Translational Medicine 2019 17:311

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  31. Content type: Research

    Adipokines in serum derive mainly from subcutaneous and visceral adipose tissues. Epicardial adipose tissue (EAT), being a relatively small but unique fat depot, probably does not make an important contributio...

    Authors: Kacper Toczylowski, Tomasz Hirnle, Dorota Harasiuk, Piotr Zabielski, Anna Lewczuk, Iwona Dmitruk, Monika Ksiazek, Artur Sulik, Jan Gorski, Adrian Chabowski and Marcin Baranowski

    Citation: Journal of Translational Medicine 2019 17:310

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  32. Content type: Review

    Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling...

    Authors: Shuaishuai Xu, Huaxiang Xu, Wenquan Wang, Shuo Li, Hao Li, Tianjiao Li, Wuhu Zhang, Xianjun Yu and Liang Liu

    Citation: Journal of Translational Medicine 2019 17:309

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  33. Content type: Research

    Estrogen receptors (ERs) are thought to play an important role in non-small cell lung cancer (NSCLC). However, the effect of ERs in NSCLC is still controversial and needs further investigation. A new considera...

    Authors: Xiujuan Gao, Yue Cai, Zhuo Wang, Wenjuan He, Sisi Cao, Rong Xu and Hui Chen

    Citation: Journal of Translational Medicine 2019 17:308

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  34. Content type: Research

    Conventional clinical biomarkers cannot accurately differentiate indolent from aggressive prostate cancer (PCa). We investigated the usefulness of a biomarker panel measured exclusively in biofluids for assess...

    Authors: Xavier Ruiz-Plazas, Esther Rodríguez-Gallego, Marta Alves, Antonio Altuna-Coy, Javier Lozano-Bartolomé, Manel Portero-Otin, Joan Francesc García-Fontgivell, Salomé Martínez-González, José Segarra and Matilde R. Chacón

    Citation: Journal of Translational Medicine 2019 17:307

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  35. Content type: Research

    Identifying how pain transitions from acute to chronic is critical in designing effective prevention and management techniques for patients’ well-being, physically, psychosocially, and financially. There is an...

    Authors: Jianzhong Su, Ying Du, Kelley Bevers, Pengcheng Xiao, John Licciardone, Marco Brotto and Robert J. Gatchel

    Citation: Journal of Translational Medicine 2019 17:306

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  36. Content type: Review

    Trauma is the leading cause of mortality in humans below the age of 40. Patients injured by accidents frequently suffer severe multiple trauma, which is life-threatening and leads to death in many cases. In mu...

    Authors: Birte Weber, Ina Lackner, Melanie Haffner-Luntzer, Annette Palmer, Jochen Pressmar, Karin Scharffetter-Kochanek, Bernd Knöll, Hubert Schrezenemeier, Borna Relja and Miriam Kalbitz

    Citation: Journal of Translational Medicine 2019 17:305

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  37. Content type: Research

    Treatment with anti-PD1 monoclonal antibodies improves the survival of metastatic melanoma patients but only a subgroup of patients benefits from durable disease control. Predictive biomarkers for durable bene...

    Authors: Teofila Seremet, Yanina Jansen, Simon Planken, Hassan Njimi, Mélanie Delaunoy, Hakim El Housni, Gil Awada, Julia Katharina Schwarze, Marleen Keyaerts, Hendrik Everaert, Danielle Lienard, Véronique Del Marmol, Pierre Heimann and Bart Neyns

    Citation: Journal of Translational Medicine 2019 17:303

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  38. Content type: Review

    The aryl hydrocarbon receptor (AhR) is a well-known ligand-activated cytoplasmic transcription factor that contributes to cellular responses against environmental toxins and carcinogens. AhR is activated by a ...

    Authors: Hui Zhao, Lin Chen, Tian Yang, Ya-Long Feng, Nosratola D. Vaziri, Bao-Li Liu, Qing-Quan Liu, Yan Guo and Ying-Yong Zhao

    Citation: Journal of Translational Medicine 2019 17:302

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  39. Content type: Correction

    Following publication of the original article [1], the authors found an error in Figure 3. The middle panel of Figure 3a was inadvertently duplicated.

    Authors: Bhuwan Giri, Vineet K. Gupta, Brianna Yaffe, Shrey Modi, Pooja Roy, Vrishketan Sethi, Shweta P. Lavania, Selwyn M. Vickers, Vikas Dudeja, Sulagna Banerjee, Justin Watts and Ashok Saluja

    Citation: Journal of Translational Medicine 2019 17:301

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    The original article was published in Journal of Translational Medicine 2019 17:163

  40. Content type: Research

    Adipose tissue remodeling plays a significant role in obesity-induced insulin resistance. Published studies reported that level of trigger receptor expressed on myeloid cells 2 (TREM2) in adipose tissue is up-...

    Authors: Can Liu, Pinhao Li, Hui Li, Sicong Wang, Lifeng Ding, Hanbin Wang, Hui Ye, Yue Jin, Jinchao Hou, Xiangming Fang and Qiang Shu

    Citation: Journal of Translational Medicine 2019 17:300

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  41. Content type: Research

    Annexins are involved in vesicle trafficking, cell proliferation and apoptosis, but their functional mechanisms in ovarian cancer remain unclear. In this study, we analyzed Annexins in ovarian cancer using dif...

    Authors: Rui Gou, Liancheng Zhu, Mingjun Zheng, Qian Guo, Yuexin Hu, Xiao Li, Juanjuan Liu and Bei Lin

    Citation: Journal of Translational Medicine 2019 17:275

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  42. Content type: Research

    Numerous evidence has suggested that long non-coding RNA (lncRNA) acts an important role in tumor biology. This study focuses on the identification of novel prognostic lncRNA biomarkers predicting tumor recurr...

    Authors: Fangyao Chen, Zhe Li, Changyu Deng and Hong Yan

    Citation: Journal of Translational Medicine 2019 17:299

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  43. Content type: Research

    BRAF mutations occur in 2–4% non-small cell lung cancer (NSCLC) patients and can be categorized into three functional classes based on signaling mechanism and kinase activity: RAS-independent kinase-activating V6...

    Authors: Quan Lin, Haoran Zhang, Huaxin Ding, Jun Qian, Analyn Lizaso, Jing Lin, Han Han-Zhang, Jianxing Xiang, Yuping Li and Hong Zhu

    Citation: Journal of Translational Medicine 2019 17:298

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  44. Content type: Research

    Mesenchymal stem cells (MSCs) are attractive cell-therapy candidates. Despite their popularity and promise, there is no uniform method of preparation of MSCs. Typically, cells are cryopreserved in liquid nitro...

    Authors: Ben Antebi, Amber M. Asher, Luis A. Rodriguez II, Robbie K. Moore, Arezoo Mohammadipoor and Leopoldo C. Cancio

    Citation: Journal of Translational Medicine 2019 17:297

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  45. Content type: Research

    This multi-institutional retrospective real life study was conducted in 22 Italian Oncology Centers and evaluated the role of Axitinib in second line treatment in not selected mRCC patients.

    Authors: Gaetano Facchini, Sabrina Rossetti, Massimiliano Berretta, Carla Cavaliere, Sarah Scagliarini, Maria Giuseppa Vitale, Chiara Ciccarese, Giuseppe Di Lorenzo, Erica Palesandro, Vincenza Conteduca, Umberto Basso, Emanuele Naglieri, Azzurra Farnesi, Michele Aieta, Nicolò Borsellino, Leonardo La Torre…

    Citation: Journal of Translational Medicine 2019 17:296

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  46. Content type: Research

    The skin is impacted by every form of external radiation therapy. However, effective therapeutic options for severe, acute radiation-induced skin reactions are limited. Although platelet-rich plasma (PRP) is k...

    Authors: Janet Lee, Hyosun Jang, Sunhoo Park, Hyunwook Myung, Kyuchang Kim, Hyewon Kim, Won-Suk Jang, Sun-Joo Lee, Jae Kyung Myung and Sehwan Shim

    Citation: Journal of Translational Medicine 2019 17:295

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