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  1. The cerebellum plays key roles in the pathology of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), but the way in which these conditions affect how the cerebellum communicates with ...

    Authors: Yuping Yang, Junle Li, Ting Li, Zhen Li, Zhizheng Zhuo, Xuemei Han, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Decai Tian, Xinli Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li…
    Citation: Journal of Translational Medicine 2023 21:352
  2. The current ageing trend of the world population has, in part, accounted for Alzheimer disease (AD) being a public health issue in recent times. Although some progress has been made in clarifying AD-related pa...

    Authors: Benson O. A. Botchway, Xuehong Liu, Yu Zhou and Marong Fang
    Citation: Journal of Translational Medicine 2023 21:351
  3. Glioblastoma multiforme (GBM) is associated with remarkably poor prognosis, and its treatment is challenging. This investigation aimed to evaluate the safety of suicide gene therapy using allogeneic adipose ti...

    Authors: Saeed Oraee-Yazdani, Roozbeh Tavanaei, Fatemeh Rostami, Atieh Hajarizadeh, Marzieh Mehrabadi, Mohammadhosein Akhlaghpasand, Mona Tamaddon, Samin Khannejad, Kaveh Oraii Yazdani and Alireza Zali
    Citation: Journal of Translational Medicine 2023 21:350
  4. Gut microbiota is closely related to human health and disease because, together with their metabolites, gut microbiota maintain normal intestinal peristalsis. The use of antibiotics or opioid anesthetics, or b...

    Authors: TianRong Ma, XiaoLei Xue, Hui Tian, XinXiu Zhou, JunKe Wang, ZhiWen Zhao, MingFei Wang, JiYuan Song, RenXiang Feng, Leping Li, Changqing Jing and Feng Tian
    Citation: Journal of Translational Medicine 2023 21:349
  5. Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against CVD are urgently needed. Mitochondria dysfunction involves in ...

    Authors: Mingchu Sun, Wenhua Jiang, Nan Mu, Zihui Zhang, Lu Yu and Heng Ma
    Citation: Journal of Translational Medicine 2023 21:347
  6. Bispecific antibody has garnered considerable attention in the recent years due to its impressive preliminary efficacy in hematological malignancies. For solid tumors, however, the main hindrance is the suppre...

    Authors: Po-Lin Huang, Hung-Tsai Kan, Ching-Hsuan Hsu, Hsin-Ta Hsieh, Wan-Chien Cheng, Ren-Yeong Huang and Jhong-Jhe You
    Citation: Journal of Translational Medicine 2023 21:346
  7. Malignant melanoma is one of the most common tumours and has the highest mortality rate of all types of skin cancers worldwide. Traditional and novel therapeutic approaches, including surgery, targeted therapy...

    Authors: Fei Du, Lu-han Yang, Jiao Liu, Jian Wang, Lianpeng Fan, Suwit Duangmano, Hao Liu, Minghua Liu, Jun Wang, Xiaolin Zhong, Zhuo Zhang and Fang Wang
    Citation: Journal of Translational Medicine 2023 21:345
  8. As leading contributors to worldwide morbidity and mortality, sepsis and septic shock are considered a major global health concern. Proactive biomarker identification in patients with sepsis suspicion at any t...

    Authors: José Luis García-Giménez, Eva García-López, Salvador Mena-Mollá, Jesús Beltrán-García, Rebeca Osca-Verdegal, Elena Nacher-Sendra, Carmen Aguado-Velasco, Germán Casabó-Vallés, Carlos Romá-Mateo, María Rodriguez-Gimillo, Oreto Antúnez, José Ferreres, Federico V. Pallardó and Nieves Carbonell
    Citation: Journal of Translational Medicine 2023 21:344
  9. Clear cell renal cell carcinoma (ccRCC) is a highly invasive and metastatic subtype of kidney malignancy and is correlated with metabolic reprogramming for adaptation to the tumor microenvironment comprising i...

    Authors: Hansen Lin, Liangmin Fu, Pengju Li, Jiangquan Zhu, Quanhui Xu, Yinghan Wang, Mukhtar Adan Mumin, Xinwei Zhou, Yuhang Chen, Guannan Shu, Gaosheng Yao, Minyu Chen, Jun Lu, Lizhen Zhang, YuJun Liu, Yiqi Zhao…
    Citation: Journal of Translational Medicine 2023 21:343
  10. The Swedish Childhood Tumor Biobank (BTB) is a nonprofit national infrastructure for collecting tissue samples and genomic data from pediatric patients diagnosed with central nervous system (CNS) and other sol...

    Authors: Teresita Díaz de Ståhl, Alia Shamikh, Markus Mayrhofer, Szilvester Juhos, Elisa Basmaci, Gabriela Prochazka, Maxime Garcia, Praveen Raj Somarajan, Katarzyna Zielinska-Chomej, Christopher Illies, Ingrid Øra, Peter Siesjö, Per-Erik Sandström, Jakob Stenman, Magnus Sabel, Bengt Gustavsson…
    Citation: Journal of Translational Medicine 2023 21:342
  11. Immunocheckpoint inhibitors (ICIs) have been widely used in the clinical treatment of lung cancer. Although clinical studies and trials have shown that patients can benefit significantly after PD-1/PD-L1 block...

    Authors: Tongyuan Qu, Wenshuai Zhang, Chenhui Yan, Danyang Ren, Yalei Wang, Yuhong Guo, Qianru Guo, Jinpeng Wang, Liren Liu, Lei Han, Lingmei Li, Qiujuan Huang, Lu Cao, Zhaoxiang Ye, Bin Zhang, Qiang Zhao…
    Citation: Journal of Translational Medicine 2023 21:341
  12. We previously demonstrated that an Italian family affected by a severe dilated cardiomyopathy (DCM) with history of sudden deaths at young age, carried a mutation in the Lmna gene encoding for a truncated variant...

    Authors: Giusy Pietrafesa, Roberta De Zio, Simona Ida Scorza, Maria Francesca Armentano, Martino Pepe, Cinzia Forleo, Giuseppe Procino, Andrea Gerbino, Maria Svelto and Monica Carmosino
    Citation: Journal of Translational Medicine 2023 21:340
  13. Disruption of N6 methyl adenosine (m6A) modulation hampers gene expression and cellular functions, leading to various illnesses. However, the role of m6A modification in osteoarthritis (OA) synovitis remains u...

    Authors: Yuheng Lu, Hongbo Zhang, Haoyan Pan, Zhicheng Zhang, Hua Zeng, Haoyu Xie, Jianbin Yin, Wen Tang, Rengui Lin, Chun Zeng and Daozhang Cai
    Citation: Journal of Translational Medicine 2023 21:339
  14. To evaluate a new class of blood-based biomarkers, anti-frameshift peptide antibodies, for predicting both tumor responses and adverse immune events to immune checkpoint inhibitor (ICI) therapies in advanced l...

    Authors: Luhui Shen, Justin R. Brown, Stephen Albert Johnston, Mehmet Altan and Kathryn F. Sykes
    Citation: Journal of Translational Medicine 2023 21:338
  15. To explore an optimal model to predict the response of patients with axillary lymph node (ALN) positive breast cancer to neoadjuvant chemotherapy (NAC) with machine learning using clinical and ultrasound-based...

    Authors: Hao Zhang, Wen Cao, Lianjuan Liu, Zifan Meng, Ningning Sun, Yuanyuan Meng and Jie Fei
    Citation: Journal of Translational Medicine 2023 21:337
  16. Depending on the needs of scientific research at a given time, biobanks make biological samples and data available to researchers. In this article, we aim to describe the reasons and underlying logic that dete...

    Authors: Desprès Caroline and Mamzer Marie-France
    Citation: Journal of Translational Medicine 2023 21:336
  17. Interleukin-17A (IL-17A), a proinflammatory cytokine primarily secreted by Th17 cells, γδT cells and natural killer T (NKT) cells, performs essential roles in the microenvironment of certain inflammation-relat...

    Authors: Wen-Qing Feng, Yu-Chen Zhang, Zhuo-Qing Xu, Su-Yue Yu, Jian-ting Huo, Abudumaimaitijiang Tuersun, Min-Hua Zheng, Jing-Kun Zhao, Ya-Ping Zong and Ai-Guo Lu
    Citation: Journal of Translational Medicine 2023 21:335
  18. Ovarian cancer (OC) has high mortality and poor prognosis for lacking of specific biomarkers and typical clinical symptoms in the early stage. CEBPG is an important regulator in tumor development, yet it is un...

    Authors: Xiaoqian Zhang, Xiaocui Zheng, Xiang Ying, Weiwei Xie, Yujia Yin and Xipeng Wang
    Citation: Journal of Translational Medicine 2023 21:334
  19. Despite numerous clinical trials and decades of endeavour, there is still no effective cure for Alzheimer's disease. Computational drug repositioning approaches may be employed for the development of new treat...

    Authors: Abdulahad Bayraktar, Xiangyu Li, Woonghee Kim, Cheng Zhang, Hasan Turkez, Saeed Shoaie and Adil Mardinoglu
    Citation: Journal of Translational Medicine 2023 21:332
  20. People with mitochondrial disease (MtD) are susceptible to metabolic decompensation and neurological symptom progression in response to an infection. Increasing evidence suggests that mitochondrial dysfunction...

    Authors: Emily B. Warren, Eliza M. Gordon-Lipkin, Foo Cheung, Jinguo Chen, Amrita Mukherjee, Richard Apps, John S. Tsang, Jillian Jetmore, Melissa L. Schlein, Shannon Kruk, Yuanjiu Lei, A. Phillip West and Peter J. McGuire
    Citation: Journal of Translational Medicine 2023 21:331
  21. Spatial transcriptomics technologies developed in recent years can provide various information including tissue heterogeneity, which is fundamental in biological and medical research, and have been making sign...

    Authors: Jun Du, Yu-Chen Yang, Zhi-Jie An, Ming-Hui Zhang, Xue-Hang Fu, Zou-Fang Huang, Ye Yuan and Jian Hou
    Citation: Journal of Translational Medicine 2023 21:330
  22. The success of allogeneic hematopoietic stem cell transplant for hematological malignancies is heavily dependent on the availability of suitable donors. Haploidentical donor (HID) and matched sibling donor (MS...

    Authors: Hengwei Wu, Yeqian Zhao, Fei Gao, Jimin Shi, Yi Luo, Jian Yu, Xiaoyu Lai, Lizhen Liu, Huarui Fu, Pengxu Qian, He Huang and Yanmin Zhao
    Citation: Journal of Translational Medicine 2023 21:329
  23. Oral squamous cell carcinoma (OSCC) is one of the most prevalent and fatal oral cancers. Mitochondria-targeting therapies represent promising strategies against various cancers, but their applications in treat...

    Authors: Yafei Zhang, Bingqian Yang, Chengwei Tu, Yifan Ping, Shuhong Chen, Tong Wu, Zheyu Zhao, Yixin Mao, Zhan Yang, Zelin Cao, Jianmin Li, Kate Huang, Xi Ding, Gang Wu, Peng Zou, Zhennan Deng…
    Citation: Journal of Translational Medicine 2023 21:328
  24. The pathogenesis of osteoporosis involves multiple factors, among which alterations in the bone microenvironment play a crucial role in disrupting normal bone metabolic balance. Transient receptor potential va...

    Authors: Zhi-heng Luo, Jian-xiong Ma, Wei Zhang, Ai-xian Tian, Shu-wei Gong, Yan Li, Yu-xiao Lai and Xin-long Ma
    Citation: Journal of Translational Medicine 2023 21:327
  25. Renal tubulointerstitial fibrosis is the hallmark of various chronic kidney diseases. Symmetric dimethylarginine (SDMA) is an independent cardiovascular risk factor in patients with chronic kidney diseases, wh...

    Authors: Yanzhe Wang, Ming Wu, Dongping Chen, Bo Tan, Pinglan Lin, Di Huang and Chaoyang Ye
    Citation: Journal of Translational Medicine 2023 21:326
  26. Polymorphisms in microRNAs (miRNAs) play an important role in acute coronary syndromes (ACS). The purpose of this study was to assess the association of miR-146a rs2910164 and miR-34b rs4938723 polymorphisms w...

    Authors: Xiang-Rui Qiao, Tao Zheng, Yifei Xie, Xinyi yao, Zuyi Yuan, Yue Wu, Dong Zhou and Tao Chen
    Citation: Journal of Translational Medicine 2023 21:325
  27. In Lung adenocarcinoma (LUAD), targeted therapies and immunotherapies have moved from metastatic to early stage and stratification of the relapse risk becomes mandatory. Here we identified a miR-200 based RNA ...

    Authors: Simon Garinet, Audrey Didelot, Laetitia Marisa, Guillaume Beinse, Marine Sroussi, Françoise Le Pimpec-Barthes, Elizabeth Fabre, Laure Gibault, Pierre Laurent-Puig, Sophie Mouillet-Richard, Antoine Legras and Hélène Blons
    Citation: Journal of Translational Medicine 2023 21:324
  28. Pericyte-myofibroblast transition (PMT) has been confirmed to contribute to renal fibrosis in several kidney diseases, and transforming growth factor-β1 (TGF-β1) is a well-known cytokine that drives PMT. Howev...

    Authors: Liangmei Chen, Xiaofan Li, Yiyao Deng, Jianwen Chen, Mengjie Huang, Fengge Zhu, Zhumei Gao, Lingling Wu, Quan Hong, Zhe Feng, Guangyan Cai, Xuefeng Sun, Xueyuan Bai and Xiangmei Chen
    Citation: Journal of Translational Medicine 2023 21:323
  29. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, heterogenous disease characterized by unexplained persistent fatigue and other features including cognitive impairment, myalgias, post-...

    Authors: Ludovic Giloteaux, Jiayin Li, Mady Hornig, W. Ian Lipkin, David Ruppert and Maureen R. Hanson
    Citation: Journal of Translational Medicine 2023 21:322
  30. The ubiquitin protein ligase E3C (UBE3C) has been reported to play an oncogenic role in breast cancer (BRCA). This work further investigates the effect of UBE3C on the radioresistance of BRCA cells.

    Authors: Yansu Wang, Ming Liu, Xiaoqian Liu and Xianling Guo
    Citation: Journal of Translational Medicine 2023 21:321
  31. Anti-PD-(L)1 immunotherapy has been recommended for non-small cell lung cancer (NSCLC) patients with lymph node metastases (LNM). However, the exact functional feature and spatial architecture of tumor-infiltr...

    Authors: Guanqun Yang, Siqi Cai, Mengyu Hu, Chaozhuo Li, Liying Yang, Wei Zhang, Jujie Sun, Fenghao Sun, Ligang Xing and Xiaorong Sun
    Citation: Journal of Translational Medicine 2023 21:320
  32. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is applied in patients with refractory hemodynamic failure. Exposure of blood components to high shear stress and the large extracorporeal surfaces i...

    Authors: Patrick Malcolm Siegel, Bálint András Barta, Lukas Orlean, Ines Derya Steenbuck, Miguel Cosenza-Contreras, Tobias Wengenmayer, Georg Trummer, Dennis Wolf, Dirk Westermann, Oliver Schilling and Philipp Diehl
    Citation: Journal of Translational Medicine 2023 21:319
  33. Nivolumab is an anti-PD1 antibody that has dramatically improved metastatic melanoma patients’ outcomes. Nevertheless, many patients are resistant to PD-1 inhibition, occasionally experiencing severe off-targe...

    Authors: Domenico Galati, Serena Zanotta, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, Marilena Romanelli, Ester Simeone, Lucia Festino, Francesca Sparano, Rosa Azzaro, Rosaria De Filippi, Antonio Pinto, Chrystal M. Paulos and Paolo A. Ascierto
    Citation: Journal of Translational Medicine 2023 21:318
  34. Pancreatic ductal adenocarcinoma (PDAC) has a low survival, its incidence is rising and little therapeutic improvements are expected in the near future. It has been observed that Epithelial-to-Mesenchymal tran...

    Authors: Jos van Pelt, Bob Meeusen, Rita Derua, Liesbeth Guffens, Eric Van Cutsem, Veerle Janssens and Chris Verslype
    Citation: Journal of Translational Medicine 2023 21:317
  35. Central precocious puberty (CPP) is a common disease in prepubertal children and results mainly from disorders in the endocrine system. Emerging evidence has highlighted the involvement of gut microbes in horm...

    Authors: Xiaoyan Huang, Jixiong Chen, Haozhe Zou, Peng Huang, Hailing Luo, Haidan Li, Yuhua Cai, Li Liu, Yongsheng Li, Xiaojie He and Wei Xiang
    Citation: Journal of Translational Medicine 2023 21:316
  36. Authors: Cheng-Jeng Tai, Tzu-Cheng Su, Ming-Chung Jiang, Hung-Chang Chen, Shing-Chuan Shen, Woan-Ruoh Lee, Ching-Fong Liao, Ying-Chun Chen, Shu-Hui Lin, Li-Tzu Li, Ko-Hung Shen, Chung-Min Yeh, Kun-Tu Yeh, Ching-Hsiao Lee, Hsin-Yi Shih and Chun-Chao Chang
    Citation: Journal of Translational Medicine 2023 21:315

    The original article was published in Journal of Translational Medicine 2013 11:29

  37. Interstitial lung diseases (ILDs) can be induced and even exacerbated by radiotherapy in thoracic cancer patients. The roles of immune responses underlying the development of these severe lung injuries are sti...

    Authors: Xinglong Liu, Liang Zeng, Yuchuan Zhou, Xinrui Zhao, Lin Zhu, Jianghong Zhang, Yan Pan, Chunlin Shao and Jiamei Fu
    Citation: Journal of Translational Medicine 2023 21:314
  38. Exosomes (EXOs), tiny extracellular vesicles that facilitate cell–cell communication, are being explored as a heart failure treatment, although the features of the cell source restrict their efficacy. Fibrobla...

    Authors: Gaia Papini, Giulia Furini, Marco Matteucci, Vanessa Biemmi, Valentina Casieri, Nicole Di Lascio, Giuseppina Milano, Lucia Rosa Chincoli, Francesco Faita, Lucio Barile and Vincenzo Lionetti
    Citation: Journal of Translational Medicine 2023 21:313
  39. Cognitive dysfunction is the most common non-motor symptom in Parkinson’s disease (PD), and timely detection of a slight cognitive decline is crucial for early treatment and prevention of dementia. This study ...

    Authors: Boyu Chen, Ming Xu, Hongmei Yu, Jiachuan He, Yingmei Li, Dandan Song and Guo Guang Fan
    Citation: Journal of Translational Medicine 2023 21:310
  40. The previous studies have revealed that abnormal RNA-binding protein Musashi-2 (MSI2) expression is associated with cancer progression through post-transcriptional mechanisms, however mechanistic details of th...

    Authors: Fanfan Li, Yixiang Han, Rongrong Chen, Yinyan Jiang, Cheng Chen, Xiaofang Wang, Jifan Zhou, Qingqing Xu, Songfu Jiang, Si Zhang, Kang Yu and Shenghui Zhang
    Citation: Journal of Translational Medicine 2023 21:309
  41. Infantile hemangioma (IH) is the most prevalent benign vascular tumor in infants, with distinct disease stages and durations. Despite the fact that the majority of IHs can regress spontaneously, a small percen...

    Authors: Meng Kong, Yanan Li, Kai Wang, Shisong Zhang and Yi Ji
    Citation: Journal of Translational Medicine 2023 21:308
  42. Cervical cancer remains one of the most prevalent cancers worldwide. Accumulating evidence suggests that specificity protein 1 (Sp1) plays a pivotal role in tumour progression. The underlying role and mechanis...

    Authors: Xu Xu, Xiaona Wang, Qihui Chen, Aman Zheng, Donglu Li, Ziqi Meng, Xinran Li, Hanchen Cai, Wangzhi Li, Shiyuan Huang and Fan Wang
    Citation: Journal of Translational Medicine 2023 21:307
  43. Gallbladder cancer (GBC) is the most prevalent and invasive biliary tract malignancy. As a GTPase-activating protein, Neurofibromin 1 (NF1) is a tumor suppressor that negatively regulates the RAS signaling pat...

    Authors: Lingxiao Zhang, Lin Jiang, Ling Zeng, Zhaohui Jin, Xuanjia Dong, Yuhan Zhang, Litian Chen, Yijun Shu, Yingbin Liu and Ying Huang
    Citation: Journal of Translational Medicine 2023 21:306
  44. Despite the wide variety of Next Generation Sequencing (NGS)-based methods, it remains challenging to detect mutations present at very low frequencies. This problem is particularly relevant in oncology, where ...

    Authors: Jonathan Bieler, Slawomir Kubik, Morgane Macheret, Christian Pozzorini, Adrian Willig and Zhenyu Xu
    Citation: Journal of Translational Medicine 2023 21:305
  45. Authors: Jinho Kim, Hyunjung Kim, Min‑Seok Lee, Heetak Lee, Yeon Jeong Kim, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Hye Kyung Hong, Sridhar Hannenhalli, Yong Beom Cho, Donghyun Park and Sun Shim Choi
    Citation: Journal of Translational Medicine 2023 21:304

    The original article was published in Journal of Translational Medicine 2023 21:209

  46. Metastatic prostate cancer (mPCa) has a poor prognosis with limited treatment options. The high mobility of tumor cells is the key driving characteristic of metastasis. However, the mechanism is complex and fa...

    Authors: Zean Li, Yiran Tao, Ze Gao, Shirong Peng, Yiming Lai, Kaiwen Li, Xu Chen and Hai Huang
    Citation: Journal of Translational Medicine 2023 21:303

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