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Table 2 Change in expression of BMSC genes during co-culture with 3 different leukemia cell lines and with CD34 + cells

From: Leukemia cells induce changes in human bone marrow stromal cells

Class comparisona Up-regulated genes Down-regulated genes Most over-represented canonical pathwaysb
  Gene symbol Fold change Genes symbol Fold change  
BMSCs co-cultured with TF-1 CXCL1 338.3 CYP3A4 -5.9 Role of IL-17A in arthritis
  IL8 168.8 PLEKHH2 -4.2 Role of IL-17 F in allergic Inflammatory airway Diseases
  CXCL3 59.4 CCNF -4.0 Role of IL-17A in Psioriasis
  CXCL2 46.6 CYP3A5 -3.9 IL-17A signaling in airway cells
  PTGS2 32.8 RBM5 -3.8  
  IL1B 26.6 BMP4 -3.8  
  IL1A 26.5 ANGPT2 -3.7  
  IL1B 23.1 GZMB -3.5  
  ICAM1 21.7 DAB2IP -3.5  
  CCL2 19.3 CYP3A7 -3.5  
BMSCs co-cultured with TF-1α IRF8 4.2 Col3a1 -14.4 Rac signaling
  SLC30A4 4.0 Gria1 -6.6 D-myo-inositol(1,4,5) triphosphate biosynthesis
  CDH7 3.2 ASB5 -5.5
  DZANK1 3.0 ABCC9 -5.2 Actin cytoskeleton signaling
  GDF2 3.0 DBIL5P -4.2 Growth hormone signaling
  NPTX1 2.9 CALB2 -3.5 Death receptor signaling
  ATPBD4 2.9 TMEM242 -3.5  
  UNC5C 2.9 EIF4EBP2 -3.4  
  YOD1 2.9 -3.1  
  CCL28 2.8 MLL2 -3.0  
BMSCs co-cultured with K562 IL8 17.4 SPOCK3 -7.1 Role of IL-17A in arthritis
  CCL2 12.6 KANK4 -6.5 Hepatic fibrosis/stellate cell activation
  PTPRR 11.9 PRSS35 -6.5 VDR/RXR activation
  IL1B 11.6 GPR85 -5.5 CD40 signaling
  CXCL1 9.2 FGF7 -4.7 IL-6 signaling
  ICAM1 8.4 SLC8A1 -4.6  
  SLC25A21 7.6 AP4E1 -4.6  
  SERPINB2 7.5 ABCC9 -4.2  
  SLC44A4 6.1 C17orf28 -4.2  
  FAM167A 5.0 FLT1 -4.1  
BMSCs co-cultured with CD34 + cells SERPINB2 3.5 UGT2B10 -2.9 Purine metabolism
  IL1B 3.4 METTL3 -2.7 Estrogen receptor signaling
  RTP3 2.8 SFP2 -2.6 mTOR signaling
  ZBED2 2.7 C5AR1 -2.5 EIF2 signaling
  CCL7 2.6 ISL2 -2.5 Aminosugars metabolism
  ERMN 2.6 KLRC3 -2.4  
  IL8 2.6 EFHD1 -2.3  
  NKAPL 2.5 RFX4 -2.3  
  TSLP 2.4 KANK4 -2.2  
  1. aComparison of co-cultured and mono-cultured BMSCs (p-value <0.05).
  2. bIngenuity pathway analysis (IPA).
  3. The genes with the greatest fold change are shown.