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Table 3 Change in expression of leukemia and CD34 + cell genes during co-cultured with BMSCs

From: Leukemia cells induce changes in human bone marrow stromal cells

Class comparison1

Up-regulated genes

Down-regulated genes

Most over-represented canonical pathways2

 

Gene symbol

Fold change

Genes symbol

Fold change

 

TF-1 cells co-cultured with BMSCs

RGS1

6.04

HARS2

-4.44

Role of NANOG in stem cells pluripotency

TST

4.93

CBL

-4.14

CNTF signaling

CD93

4.46

WDR31

-3.56

Growth hormone signaling

AZGP1

4.34

PIGR

-3.37

IGF-1 signaling

CD200R1

3.95

SLC12A1

-3.19

Stem cells pluripotency

CTNND!

3.37

CTTNBP2

-3.11

ASAP2

3.28

C6orf105

-2.97

CLEC4M

3.23

ATP2B4

-2.79

CACNA1F

3.20

SLC16A6

-2.75

 

SOCS7

3.19

SLC38A10

-2.74

 

TF-1α cells co-cultured with BMSCs

FAM69A

4.22

ADPRH

-7.62

Role of macrophages in rheumatoid arthritis

LIM2

3.96

SIGLEC12

-6.85

Axonal guidance signaling

KCNMB2

3.60

XIRP2

-5.00

Basal cell carcinoma signaling

C1QL1

3.28

KRT2

-4.42

G-protein coupled receptor signaling

TULP1

3.27

GPR180

-3.91

ERK/MAPK signaling

DIS3

3.22

KLHL1

-3.87

IGFBP4

3.22

GALNT4

-3.55

SSPN

3.19

PDGFC

-3.50

ATP11A

3.18

PFN4

-3.32

 

SLC25A2

3.07

GPR37L1

-3.27

 

K562 cells co-cultured with BMSCs

SKG1

3.66

EPB42

-5.78

Role of Oct4 in stem cell pluripotency

KLARN

3.41

EPX

-5.00

Antigen presentation pathway

CNN1

3.31

BPIFA1

-4.38

TGF-β signaling

AFF3

3.11

LEPR

-3.93

Regulation of IL-2 expression in T lymphocyte

SKIL

3.04

ANKRD11

-3.24

Semaphorin signaling in neurons

SLC2A12

2.93

HIST1H1B

-3.18

ATXN7

2.80

SORBS1

-3.15

LEFTY1

2.52

CYP4A11

-3.10

DMBT1

2.41

GRWD1

-3.07

 

CELF2

2.34

CNOT4

-2.91

 

CD34 + cells co-cultured with BMSCs

SOCS3

14.45

HMOX1

-3.26

cAMP-mediated signaling

REN

11.56

C18orf1

-3.17

VDR/RXR activation

ECEL1

7.70

POU2F2

-3.09

Cardiac β-adrenergic signaling

ATP6V0A4

7.63

PLD4

-3.07

Dopamine-DARPP32 feedback in cAMP signaling

NR4A3

6.83

GPR44

-3.06

GEM

6.79

RXFP1

-2.93

HAS1

6.64

TNFSF14

-2.92

KIAA1199

6.48

ENC1

-2.78

PDLIM3

6.22

CST6

-2.68

 

CXCL6

5.74

CYTH4

-2.62

 
  1. 1Comparison of leukemia or CD34+ cells co-cultured with BMSCs compared with mono-cultured leukemia or CD34+ cells (p-value < 0.05, FDR < 0.01).
  2. 2Ingenuity Pathway Analysis (IPA).