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Table 3 Change in expression of leukemia and CD34 + cell genes during co-cultured with BMSCs

From: Leukemia cells induce changes in human bone marrow stromal cells

Class comparison1 Up-regulated genes Down-regulated genes Most over-represented canonical pathways2
  Gene symbol Fold change Genes symbol Fold change  
TF-1 cells co-cultured with BMSCs RGS1 6.04 HARS2 -4.44 Role of NANOG in stem cells pluripotency
TST 4.93 CBL -4.14 CNTF signaling
CD93 4.46 WDR31 -3.56 Growth hormone signaling
AZGP1 4.34 PIGR -3.37 IGF-1 signaling
CD200R1 3.95 SLC12A1 -3.19 Stem cells pluripotency
CTNND! 3.37 CTTNBP2 -3.11
ASAP2 3.28 C6orf105 -2.97
CLEC4M 3.23 ATP2B4 -2.79
CACNA1F 3.20 SLC16A6 -2.75
  SOCS7 3.19 SLC38A10 -2.74  
TF-1α cells co-cultured with BMSCs FAM69A 4.22 ADPRH -7.62 Role of macrophages in rheumatoid arthritis
LIM2 3.96 SIGLEC12 -6.85 Axonal guidance signaling
KCNMB2 3.60 XIRP2 -5.00 Basal cell carcinoma signaling
C1QL1 3.28 KRT2 -4.42 G-protein coupled receptor signaling
TULP1 3.27 GPR180 -3.91 ERK/MAPK signaling
DIS3 3.22 KLHL1 -3.87
IGFBP4 3.22 GALNT4 -3.55
SSPN 3.19 PDGFC -3.50
ATP11A 3.18 PFN4 -3.32
  SLC25A2 3.07 GPR37L1 -3.27  
K562 cells co-cultured with BMSCs SKG1 3.66 EPB42 -5.78 Role of Oct4 in stem cell pluripotency
KLARN 3.41 EPX -5.00 Antigen presentation pathway
CNN1 3.31 BPIFA1 -4.38 TGF-β signaling
AFF3 3.11 LEPR -3.93 Regulation of IL-2 expression in T lymphocyte
SKIL 3.04 ANKRD11 -3.24 Semaphorin signaling in neurons
SLC2A12 2.93 HIST1H1B -3.18
ATXN7 2.80 SORBS1 -3.15
LEFTY1 2.52 CYP4A11 -3.10
DMBT1 2.41 GRWD1 -3.07
  CELF2 2.34 CNOT4 -2.91  
CD34 + cells co-cultured with BMSCs SOCS3 14.45 HMOX1 -3.26 cAMP-mediated signaling
REN 11.56 C18orf1 -3.17 VDR/RXR activation
ECEL1 7.70 POU2F2 -3.09 Cardiac β-adrenergic signaling
ATP6V0A4 7.63 PLD4 -3.07 Dopamine-DARPP32 feedback in cAMP signaling
NR4A3 6.83 GPR44 -3.06
GEM 6.79 RXFP1 -2.93
HAS1 6.64 TNFSF14 -2.92
KIAA1199 6.48 ENC1 -2.78
PDLIM3 6.22 CST6 -2.68
  CXCL6 5.74 CYTH4 -2.62  
  1. 1Comparison of leukemia or CD34+ cells co-cultured with BMSCs compared with mono-cultured leukemia or CD34+ cells (p-value < 0.05, FDR < 0.01).
  2. 2Ingenuity Pathway Analysis (IPA).