Immunobiology and immunotherapy

Section edited by Adrian Bot

This section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Edited by Pedro Romero.

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  1. Research

    Amelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance

    Foxp3 is a key regulator of the development and function of regulatory T cells (Tregs), and its expression is thought to be T cell-restricted. We found that B cells in mice can express Foxp3 and B cells expres...

    Mi Kyung Park, Young Ok Jung, Seon-Yeong Lee, Seung Hoon Lee, Yu Jung Heo, Eun Kyung Kim, Hye Jwa Oh, Young Mee Moon, Hye-Jin Son, Min Jung Park, Sung Hwan Park, Ho Youn Kim, Mi La Cho and Jun Ki Min

    Journal of Translational Medicine 2016 14:191

    Published on: 28 June 2016

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:221

  2. Research

    Rebamipide prevents peripheral arthritis and intestinal inflammation by reciprocally regulating Th17/Treg cell imbalance in mice with curdlan-induced spondyloarthritis

    Spondyloarthritis (SpA) usually manifests as arthritis of the axial and peripheral joints but can also result in extra-articular manifestations such as inflammatory bowel disease. Proinflammatory cytokine inte...

    Hong-Ki Min, Jae-Kyung Kim, Seon-Yeong Lee, Eun-Kyung Kim, Seung Hoon Lee, Jennifer Lee, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park

    Journal of Translational Medicine 2016 14:190

    Published on: 27 June 2016

  3. Research

    TWEAK-binding autoantibodies are generated during psoriatic arthritis and are not influenced by anti-TNF therapy

    TNF weakly inducer of apoptosis (TWEAK) is member of the TNF ligand superfamily. Various data support that TWEAK produced by synovial macrophages may contribute to synovitis observed in psoriatic arthritis (P...

    Sandrine Guis, Philippe Berbis, Delphine Stephan, Daniel Bertin, Florent Amatore, Nathalie Balandraud, Nathalie Lesavre and Sophie Desplat-Jégo

    Journal of Translational Medicine 2016 14:185

    Published on: 23 June 2016

  4. Research

    Exosomes in the nose induce immune cell trafficking and harbour an altered protein cargo in chronic airway inflammation

    Exosomes are nano-sized extracellular vesicles participating in cell-to-cell communication both in health and disease. However, the knowledge about the functions and molecular composition of exosomes in the up...

    Cecilia Lässer, Serena E. O’Neil, Ganesh V. Shelke, Carina Sihlbom, Sara F. Hansson, Yong Song Gho, Bo Lundbäck and Jan Lötvall

    Journal of Translational Medicine 2016 14:181

    Published on: 20 June 2016

  5. Research

    Decreased IL-17 during treatment of sputum smear-positive pulmonary tuberculosis due to increased regulatory T cells and IL-10

    Tuberculosis (TB) remains a major public health concern worldwide. Previous studies have demonstrated that IL-17 plays an important role in initial immune response and is involved in both immune-mediated prote...

    Lichen Xu, Guangying Cui, Hongyu Jia, Yunan Zhu, Yulong Ding, Jianing Chen, Chong Lu, Ping Ye, Hainv Gao, Lanjuan Li, Weihang Ma, Jianxin Lyu and Hongyan Diao

    Journal of Translational Medicine 2016 14:179

    Published on: 16 June 2016

  6. Research

    ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

    The risk for developing cardiovascular disease is greater in patients with rheumatoid arthritis (RA) than in the general population. While patients with RA also have dyslipidemia, the impact of dyslipidemia on...

    Amy M. Archer, Rana Saber, Shawn Rose, Alexander Shaffer, Alexander V. Misharin, FuNien Tsai, G. Kenneth Haines III, Salina Dominguez, Mesut Eren, Douglas E. Vaughan, Carla M. Cuda and Harris Perlman

    Journal of Translational Medicine 2016 14:170

    Published on: 10 June 2016

  7. Research

    Organizing pneumonia in mice and men

    Organizing pneumonia is a reaction pattern and an inflammatory response to acute lung injuries, and is characterized by intraluminal plugs of granulation tissue in distal airspaces. In contrast to other fibrot...

    Nicole Izykowski, Mark Kuehnel, Kais Hussein, Kristin Mitschke, Michael Gunn, Sabina Janciauskiene, Axel Haverich, Gregor Warnecke, Florian Laenger, Ulrich Maus and Danny Jonigk

    Journal of Translational Medicine 2016 14:169

    Published on: 10 June 2016

  8. Research

    Vaccination with endosomal unknown epitopes produces therapeutic response in rheumatoid arthritis patients and modulates adjuvant arthritis of rats

    Our previous results showed that intrasynovial Rifamycin SV caused the lysis of synoviocites and freed the autoantigens which in turn stimulated the immunoregulatory rather than autoreactive T cell response in...

    Innocenzo Caruso, Salvatore Santandrea, Mariarita Gismondo, Alessandra Lombardi, Franco Montrone, Enzo Massimo Caruso and Piercarlo Sarzi Puttini

    Journal of Translational Medicine 2016 14:162

    Published on: 7 June 2016

  9. Research

    Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages

    NLRP3 inflammasome has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). The activation of NLRP3 inflammasome results in the production of IL-1β and the subsequent inflammation. Anti-d...

    Hui Zhang, Rong Fu, Chaohuan Guo, Yuefang Huang, Hongyue Wang, Shuang Wang, Jijun Zhao and Niansheng Yang

    Journal of Translational Medicine 2016 14:156

    Published on: 1 June 2016

  10. Research

    Norovirus (NoV) specific protective immune responses induced by recombinant P dimer vaccine are enhanced by the mucosal adjuvant FlaB

    Noroviruses (NoVs) are a major cause of childhood gastroenteritis and foodborne diseases worldwide. Lack of appropriate animal models or cell-based culture systems makes the development and evaluation of NoV-s...

    Vivek Verma, Wenzhi Tan, Sao Puth, Kyoung-Oh Cho, Shee Eun Lee and Joon Haeng Rhee

    Journal of Translational Medicine 2016 14:135

    Published on: 17 May 2016

  11. Research

    Autoantigen-specific immunosuppression with tolerogenic peripheral blood cells prevents relapses in a mouse model of relapsing-remitting multiple sclerosis

    Dendritic cells (DCs) rendered suppressive by treatment with mitomycin C and loaded with the autoantigen myelin basic protein demonstrated earlier their ability to prevent experimental autoimmune encephalomyel...

    Christian Kleist, Elisabeth Mohr, Sadanand Gaikwad, Laura Dittmar, Stefanie Kuerten, Michael Platten, Walter Mier, Michael Schmitt, Gerhard Opelz and Peter Terness

    Journal of Translational Medicine 2016 14:99

    Published on: 1 May 2016

  12. Research

    CTLA-4 polymorphisms and haplotype correlate with survival in ALL after allogeneic stem cell transplantation from related HLA-haplotype-mismatched donor

    Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been established as an effective treatment for patients with hematological malignancies. Disease relapse remains a major cause of transplant f...

    X.-Y. Qin, Y. Wang, G.-X. Li, Y.-Z. Qin, F.-R. Wang, L.-P. Xu, H. Chen, W. Han, J.-Z. Wang, X.-H. Zhang, Y.-J. Chang, K.-Y. Liu, Z.-F. Jiang and X.-J. Huang

    Journal of Translational Medicine 2016 14:100

    Published on: 27 April 2016

  13. Research

    GIFT4 fusokine converts leukemic B cells into immune helper cells

    Chronic lymphocytic leukemia (CLL) remains incurable with standard therapy, and is characterized by excessive expansion of monoclonal abnormal mature B cells and more regulatory immune properties of T cell com...

    Jiusheng Deng, Andrea Pennati, Jonathon B. Cohen, Yuanqiang Wu, Spencer Ng, Jian Hui Wu, Christopher R. Flowers and Jacques Galipeau

    Journal of Translational Medicine 2016 14:106

    Published on: 27 April 2016

  14. Research

    Fn14-Fc suppresses germinal center formation and pathogenic B cells in a lupus mouse model via inhibition of the TWEAK/Fn14 Pathway

    Systemic lupus erythematosus (SLE) is an autoimmune-mediated chronic inflammatory disease. Half of patients with SLE suffer from lupus nephritis, which is major cause of death in SLE. TNF-like weak inducer of ...

    Hong-Ki Min, Sung-Min Kim, Jin-Sil Park, Jae-Kyeong Byun, Jennifer Lee, Seung-Ki Kwok, Young-Woo Park, Mi-La Cho and Sung-Hwan Park

    Journal of Translational Medicine 2016 14:98

    Published on: 21 April 2016

  15. Research

    ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients

    Natural Killer (NK) cell effector functions are dependent on phosphorylation of the mitogen-activated protein kinases (MAPK) pathway to produce an effective immune response for the clearance of target cells in...

    Teilah Kathryn Huth, Donald Staines and Sonya Marshall-Gradisnik

    Journal of Translational Medicine 2016 14:97

    Published on: 21 April 2016

  16. Research

    Unexpected impairment of TNF-α-induced maturation of human dendritic cells in vitro by IL-4

    An efficient strategy for programing dendritic cells (DCs) for cancer immunotherapy is the optimization of their maturation so that they can efficiently stimulate cancer-specific T cell responses. Interleukin ...

    Valérie Chabot, Laurence Martin, Daniel Meley, Luc Sensebé, Christophe Baron, Yvon Lebranchu, Frédéric Dehaut and Florence Velge-Roussel

    Journal of Translational Medicine 2016 14:93

    Published on: 14 April 2016

  17. Research

    Combination of double negative T cells and anti-thymocyte serum reverses type 1 diabetes in NOD mice

    Double-negative (DN) T cells could delay the onset and the progression of autoimmune diabetes, yet they were less efficient on reversing autoimmune diabetes. The aim of this study was to investigate whether th...

    Tianhui Liu, Min Cong, Guangyong Sun, Ping Wang, Yue Tian, Wen Shi, Xinmin Li, Hong You and Dong Zhang

    Journal of Translational Medicine 2016 14:57

    Published on: 24 February 2016

  18. Research

    Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation

    Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA chall...

    Irma Mahmutovic Persson, Hamid Akbarshahi, Mandy Menzel, Angelica Brandelius and Lena Uller

    Journal of Translational Medicine 2016 14:52

    Published on: 16 February 2016

  19. Research

    Fusion cytokine IL-2-GMCSF enhances anticancer immune responses through promoting cell–cell interactions

    Potent antitumor responses can be induced through cytokine immunotherapy. Interleukin (IL)-2 and granulocyte–macrophage colony-stimulating factor (GM-CSF) are among the most effective cytokines to induce tumo...

    Qian Wen, Wenjing Xiong, Jianchun He, Shimeng Zhang, Xialin Du, Sudong Liu, Juanjuan Wang, Mingqian Zhou and Li Ma

    Journal of Translational Medicine 2016 14:41

    Published on: 5 February 2016

  20. Research

    Differential impact of two doses of antithymocyte globulin conditioning on lymphocyte recovery upon haploidentical hematopoietic stem cell transplantation

    In vivo depletion of host T cells with antithymocyte globulin (ATG) is a common strategy for preventing graft-versus-host disease in allogeneic hematopoietic stem cell transplantation (HSCT). The total dose of...

    Jiangying Liu, Lan-Ping Xu, Zhilei Bian, Ying-Jun Chang, Yu Wang, Xiao-Hui Zhang and Xiao-Jun Huang

    Journal of Translational Medicine 2015 13:391

    Published on: 30 December 2015

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