Disease biomarkers

Section edited by Xiangdong Wang

This section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

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  1. Research

    Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease

    We recently demonstrated a positive effect of berberine on nonalcoholic fatty liver disease patients after 16 weeks of treatment by comparing mere lifestyle intervention in type 2 diabetes patients with berber...

    Xinxia Chang, Zhe Wang, Jinlan Zhang, Hongmei Yan, Hua Bian, Mingfeng Xia, Huandong Lin, Jiandong Jiang and Xin Gao

    Journal of Translational Medicine 2016 14:266

    Published on: 15 September 2016

  2. Research

    Salivary psoriasin (S100A7) correlates with diffusion capacity of carbon monoxide in a large cohort of systemic sclerosis patients

    Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and the internal organs. In a previous work we suggested a correlation between levels of salivary psoriasin (...

    Laura Giusti, Francesca Sernissi, Elena Donadio, Federica Ciregia, Camillo Giacomelli, Gino Giannaccini, Maria Rosa Mazzoni, Antonio Lucacchini and Laura Bazzichi

    Journal of Translational Medicine 2016 14:262

    Published on: 8 September 2016

  3. Research

    Biomarkers of inflammation and innate immunity in atrophic nonunion fracture

    Nonunion is a failure of healing following a bone fracture. Its physiopathology remains partially unclear and the discovery of new mediators could promote the understanding of bone healing.

    Dominique de Seny, Gaël Cobraiville, Pierre Leprince, Marianne Fillet, Charlotte Collin, Myrielle Mathieu, Jean-Philippe Hauzeur, Valérie Gangji and Michel G. Malaise

    Journal of Translational Medicine 2016 14:258

    Published on: 6 September 2016

  4. Review

    Ockham’s razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer

    Idiopathic pulmonary fibrosis (IPF) identifies a specific lung disorder characterized by chronic, progressive fibrosing interstitial pneumonia of unknown etiology, which lacks effective treatment. According to...

    Giulia M. Stella, Alessandra Gentile, Alice Baderacchi, Federica Meloni, Melissa Milan and Silvia Benvenuti

    Journal of Translational Medicine 2016 14:256

    Published on: 2 September 2016

  5. Research

    Methylation pattern analysis in prostate cancer tissue: identification of biomarkers using an MS-MLPA approach

    Epigenetic silencing mediated by CpG island methylation is a common feature of many cancers. Characterizing aberrant DNA methylation changes associated with prostate carcinogenesis could potentially identify a...

    Giorgia Gurioli, Samanta Salvi, Filippo Martignano, Flavia Foca, Roberta Gunelli, Matteo Costantini, Giacomo Cicchetti, Ugo De Giorgi, Persio Dello Sbarba, Daniele Calistri and Valentina Casadio

    Journal of Translational Medicine 2016 14:249

    Published on: 30 August 2016

  6. Research

    Salivary peptidome profiling for diagnosis of severe early childhood caries

    Severe early childhood caries (s-ECC), which has quite high prevalence among children, is a widespread problem with significant impacts among both developing and developed countries. At present, it is widely k...

    Xiangyu Sun, Xin Huang, Xu Tan, Yan Si, Xiaozhe Wang, Feng Chen and Shuguo Zheng

    Journal of Translational Medicine 2016 14:240

    Published on: 15 August 2016

  7. Research

    Role of KIR and CD16A genotypes in colorectal carcinoma genetic risk and clinical stage

    NK cell cytotoxicity is regulated by the types of the interaction between killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) class I ligands on target cells and the different binding...

    Angelica Canossi, Anna Aureli, Tiziana Del Beato, Piero Rossi, Luana Franceschilli, Flavio De Sanctis, Pierpaolo Sileri, Nicola di Lorenzo, Oreste Buonomo, Davide Lauro, Adriano Venditti and Giuseppe Sconocchia

    Journal of Translational Medicine 2016 14:239

    Published on: 12 August 2016

  8. Research

    Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients

    Hemodialysis patients have higher rates of cardiovascular morbidity and mortality compared to the general population. Mannose-binding lectin (MBL) plays an important role in the development of cardiovascular d...

    Felix Poppelaars, Mariana Gaya da Costa, Stefan P. Berger, Solmaz Assa, Anita H. Meter-Arkema, Mohamed R. Daha, Willem J. van Son, Casper F. M. Franssen and Marc A. J. Seelen

    Journal of Translational Medicine 2016 14:236

    Published on: 5 August 2016

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:245

  9. Research

    miRNAs and sports: tracking training status and potentially confounding diagnoses

    The dependency of miRNA abundance from physiological processes such as exercises remains partially understood. We set out to analyze the effect of physical exercises on miRNA profiles in blood and plasma of en...

    Anne Hecksteden, Petra Leidinger, Christina Backes, Stefanie Rheinheimer, Mark Pfeiffer, Alexander Ferrauti, Michael Kellmann, Farbod Sedaghat, Benjamin Meder, Eckart Meese, Tim Meyer and Andreas Keller

    Journal of Translational Medicine 2016 14:219

    Published on: 26 July 2016

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:293

  10. Research

    Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk

    Colorectal cancer is a preventable disease if caught at early stages. This disease is highly aggressive and has a higher incidence in African Americans. Several biomarkers and mutations of aggressive tumor beh...

    Hassan Ashktorab, Pia Hermann, Mehdi Nouraie, Babak Shokrani, Edward Lee, Tahmineh Haidary, Hassan Brim and Ulrike Stein

    Journal of Translational Medicine 2016 14:215

    Published on: 20 July 2016

  11. Research

    Serum metabolites predict response to angiotensin II receptor blockers in patients with diabetes mellitus

    Individual patients show a large variability in albuminuria response to angiotensin receptor blockers (ARB). Identifying novel biomarkers that predict ARB response may help tailor therapy. We aimed to discover...

    Michelle J. Pena, Andreas Heinzel, Peter Rossing, Hans-Henrik Parving, Guido Dallmann, Kasper Rossing, Steen Andersen, Bernd Mayer and Hiddo J. L. Heerspink

    Journal of Translational Medicine 2016 14:203

    Published on: 5 July 2016

  12. Research

    miR-122-mediated translational repression of PEG10 and its suppression in human hepatocellular carcinoma

    Hepatocellular carcinoma (HCC), a primary liver malignancy, is the most common cancer in males and fourth common cancer in females in Taiwan. HCC patients usually have a poor prognosis due to late diagnosis. I...

    Yu-Chiau Shyu, Tung-Liang Lee, Mu-Jie Lu, Jim-Ray Chen, Rong-Nan Chien, Huang-Yang Chen, Ji-Fan Lin, Ann-Ping Tsou, Yu-Hsien Chen, Chia-Wen Hsieh and Ting-Shuo Huang

    Journal of Translational Medicine 2016 14:200

    Published on: 2 July 2016

  13. Research

    HBx-induced MiR-1269b in NF-κB dependent manner upregulates cell division cycle 40 homolog (CDC40) to promote proliferation and migration in hepatoma cells

    Occurrence and progression of hepatocellular carcinoma (HCC) are associated with hepatitis B virus (HBV) infection. miR-1269b is up-regulated in HCC cells and tissues. However, the regulation of miR-1269b expr...

    Xiao-xiao Kong, Yan-ru Lv, Li-ping Shao, Xiang-yang Nong, Guang-ling Zhang, Yi Zhang, Hong-xia Fan, Min Liu, Xin Li and Hua Tang

    Journal of Translational Medicine 2016 14:189

    Published on: 27 June 2016

  14. Research

    MicroRNA-142-5p contributes to Hashimoto’s thyroiditis by targeting CLDN1

    MicroRNAs have the potential as diagnostic biomarkers and therapeutic targets in autoimmune diseases. However, very limited studies have evaluated the expression of microRNA profile in thyroid gland related to...

    Jin Zhu, Yuehua Zhang, Weichen Zhang, Wei Zhang, Linni Fan, Lu Wang, Yixiong Liu, Shasha Liu, Ying Guo, Yingmei Wang, Jun Yi, Qingguo Yan, Zhe Wang and Gaosheng Huang

    Journal of Translational Medicine 2016 14:166

    Published on: 8 June 2016

  15. Research

    Genetic variants of DNA repair genes predict the survival of patients with esophageal squamous cell cancer receiving platinum-based adjuvant chemotherapy

    Adjuvant chemotherapy in patients with resected esophageal squamous cell cancer (ESCC) remains controversial for its uncertain role in improving overall survival (OS). Nucleotide excision repair (NER) removes ...

    Fei Zhou, Meiling Zhu, Mengyun Wang, Lixin Qiu, Lei Cheng, Ming Jia, Jiaqing Xiang and Qingyi Wei

    Journal of Translational Medicine 2016 14:154

    Published on: 31 May 2016

  16. Research

    Measurement of 1,5-anhydroglucitol in blood and saliva: from non-targeted metabolomics to biochemical assay

    Diabetes testing using saliva, rather than blood and urine, could facilitate diabetes screening in public spaces. We previously identified 1,5-anhydro-d-glucitol (1,5-AG) in saliva as a diabetes biomarker. The Gl...

    Anna Halama, Michal Kulinski, Sara Abdul Kader, Noothan J. Satheesh, Abdul Badi Abou-Samra, Karsten Suhre and Ramzi M. Mohammad

    Journal of Translational Medicine 2016 14:140

    Published on: 18 May 2016

  17. Research

    An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma

    The prognosis of children with metastatic stage 4 neuroblastoma (NB) has remained poor in the past decade.

    Daniela Formicola, Giuseppe Petrosino, Vito Alessandro Lasorsa, Piero Pignataro, Flora Cimmino, Simona Vetrella, Luca Longo, Gian Paolo Tonini, André Oberthuer, Achille Iolascon, Matthias Fischer and Mario Capasso

    Journal of Translational Medicine 2016 14:142

    Published on: 17 May 2016

  18. Research

    MYC copy gain, chromosomal instability and PI3K activation as potential markers of unfavourable outcome in trastuzumab-treated patients with metastatic breast cancer

    There is an unmet need for more efficient patient stratification for receiving trastuzumab in the metastatic breast cancer (mBC) setting, since only part of such patients benefit from the addition of this agen...

    Helen Gogas, Vassiliki Kotoula, Zoi Alexopoulou, Christos Christodoulou, Ioannis Kostopoulos, Mattheos Bobos, Georgia Raptou, Elpida Charalambous, Eleftheria Tsolaki, Ioannis Xanthakis, George Pentheroudakis, Angelos Koutras, Dimitrios Bafaloukos, Pavlos Papakostas, Gerasimos Aravantinos, Amanda Psyrri…

    Journal of Translational Medicine 2016 14:136

    Published on: 17 May 2016

  19. Research

    PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma

    Esophageal squamous cell carcinoma (ESCC) is one of the most aggressively malignant tumors with dismal prognosis. Profilin 2 (PFN2) is an actin-binding protein that regulates the dynamics of actin polymerizati...

    Xiao-bin Cui, Shu-mao Zhang, Yue-xun Xu, Hong-wei Dang, Chun-xia Liu, Liang-hai Wang, Lan Yang, Jian-ming Hu, Wei-hua Liang, Jin-fang Jiang, Na Li, Yong Li, Yun-zhao Chen and Feng Li

    Journal of Translational Medicine 2016 14:137

    Published on: 17 May 2016

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