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  1. The identifying of B-cell lymphoma 2 (Bcl-2) as a therapeutic target has led to a paradigm shift in acute myeloid leukemia (AML) treatment. Pyroptosis is a novel antitumor therapeutic mechanism due to its cyto...

    Authors: Fanghua Ye, Wen Zhang, Chenying Fan, Jiajia Dong, Min Peng, Wenjun Deng, Hui Zhang and Liangchun Yang
    Citation: Journal of Translational Medicine 2023 21:606
  2. Glycolysis under normoxic conditions, known as the Warburg effect, confers a selective advantage for the survival and proliferation of many tumors. In this study, we investigated the role of estrogen-related r...

    Authors: Tianxiao Wang, Yongjun Zhu, Lu Chen, WenXin Zhang, Huijie Qi, Xiaojin Shi, Mingkang Zhong, Haifei Chen and Qunyi Li
    Citation: Journal of Translational Medicine 2023 21:605
  3. Neuroblastoma (NB) and pheochromocytoma/paraganglioma (PHEO/PGL) are neuroendocrine tumors. Imaging of these neoplasms is performed by scintigraphy after injection of radiolabeled meta-iodobenzylguanidine (mIBG),...

    Authors: Joana Grand-Guillaume, Rosalba Mansi, Raghuvir H. Gaonkar, Sandra Zanger, Melpomeni Fani, Philippe J. Eugster, Maja Beck Popovic, Eric Grouzmann and Karim Abid
    Citation: Journal of Translational Medicine 2023 21:604
  4. The early differential diagnosis between bacterial meningitis (BM) and tuberculous meningitis (TBM) or cryptococcal meningitis (CM) remains a significant clinical challenge. Neutrophil Gelatinase-Associated Li...

    Authors: Qi Wang, Qingwen Lin, Haiyan Wang, Minjie Tang, Kengna Fan, Zeqin Zhang, Er Huang, Weiqing Zhang, Fengqing Wang, Qishui Ou and Xiaofeng Liu
    Citation: Journal of Translational Medicine 2023 21:603
  5. Cell-based strategies focusing on replacement or protection of dopaminergic neurons have been considered as a potential approach to treat Parkinson’s disease (PD) for decades. However, despite promising precli...

    Authors: Fang Wang, Zhengwu Sun, Daoyong Peng, Shikha Gianchandani, Weidong Le, Johannes Boltze and Shen Li
    Citation: Journal of Translational Medicine 2023 21:601
  6. A chromobox homologue 3 (CBX3) is elevated in various cancers and significantly contributes to the promotion of malignant behavior; despite this, its exact involvement in clear cell renal cell carcinoma (ccRCC...

    Authors: Jiasheng Chen, Yuxin Lin, Shukai zheng, Qingshan Chen, Shijie Tang and Xiaoping Zhong
    Citation: Journal of Translational Medicine 2023 21:600
  7. Sialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) has emerged as a novel immunotherapy candidate, which deserves a comprehensive investigation in lung adenocarcinoma (LUAD).

    Authors: Baihui Li, Yan Guo, Yeran Yi, Ziqi Huang, Yulin Ren, Hao Wang and Lili Yang
    Citation: Journal of Translational Medicine 2023 21:599
  8. The advent of immunotherapy, a groundbreaking advancement in cancer treatment, has given rise to the prominence of the tumor microenvironment (TME) as a critical area of research. The clinical implications of ...

    Authors: Wendi Kang, Xiang Qiu, Yingen Luo, Jianwei Luo, Yang Liu, Junqing Xi, Xiao Li and Zhengqiang Yang
    Citation: Journal of Translational Medicine 2023 21:598
  9. Triple negative breast cancer (TNBC) is a major subtype of breast cancer, with limited therapeutic drugs in clinical. Epidermal growth factor receptor (EGFR) is reported to be overexpressed in various TNBC cel...

    Authors: Tianfeng Yang, Runze Yu, Cheng Cheng, Jian Huo, Zhengyan Gong, Hanbing Cao, Yu Hu, Bingling Dai and Yanmin Zhang
    Citation: Journal of Translational Medicine 2023 21:597
  10. Ovarian cancer (OC) is a highly aggressive gynecological malignancy prevalent worldwide. Most OC cases are typically diagnosed at advanced stages, which has led to a 5-year overall survival rate of less than 3...

    Authors: Haihong Zhao, Lina Wu, Jiemin Dai, Ke Sun, Zhenguo Zi, Junhua Guan and Liwen Zhang
    Citation: Journal of Translational Medicine 2023 21:596
  11. Fibromyalgia (FM) is a multifaceted disease. Along with the genetic, environmental and neuro-hormonal factors, inflammation has been assumed to have role in the pathogenesis of FM. The aim of the present study...

    Authors: Menghui Yao, Shuolin Wang, Yingdong Han, He Zhao, Yue Yin, Yun Zhang and Xuejun Zeng
    Citation: Journal of Translational Medicine 2023 21:594
  12. The tumor microenvironment (TME) is a supportive environment responsible for promoting the growth and proliferation of tumor cells. Current studies have revealed that the bone marrow mesenchymal stem cells (BM...

    Authors: Chengyun Pan, Tianzhen Hu, Ping Liu, Dan Ma, Shuyun Cao, Qin Shang, Luxin Zhang, Qingzhen Chen, Qin Fang and Jishi Wang
    Citation: Journal of Translational Medicine 2023 21:593
  13. Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity. This results in the accumulation of globotriaosylceramid...

    Authors: Hassan Osman Alhassan Elsaid, Mariell Rivedal, Eleni Skandalou, Einar Svarstad, Camilla Tøndel, Even Birkeland, Øystein Eikrem, Janka Babickova, Hans-Peter Marti and Jessica Furriol
    Citation: Journal of Translational Medicine 2023 21:591
  14. Radiation-induced lung injury (RILI) is a prevalent complication of thoracic radiotherapy in cancer patients. A comprehensive understanding of the underlying mechanisms of RILI is essential for the development...

    Authors: Jianjiao Ni, Tiantian Guo, Yue Zhou, Shanshan Jiang, Long Zhang and Zhengfei Zhu
    Citation: Journal of Translational Medicine 2023 21:590
  15. The influence of the historical cardiovascular risk status on future risk of atherosclerotic cardiovascular disease (ASCVD) is poorly understood. We aimed to investigate the association between 5-year changes ...

    Authors: Jiayi Yi, Lili Wang, Xinli Guo and Xiangpeng Ren
    Citation: Journal of Translational Medicine 2023 21:589
  16. Lower-grade glioma (LGG) is a highly heterogeneous disease that presents challenges in accurately predicting patient prognosis. Mitochondria play a central role in the energy metabolism of eukaryotic cells and...

    Authors: Hu Qin, Aimitaji Abulaiti, Aierpati Maimaiti, Zulihuma Abulaiti, Guofeng Fan, Yirizhati Aili, Wenyu Ji, Zengliang Wang and Yongxin Wang
    Citation: Journal of Translational Medicine 2023 21:588
  17. Chronic obstructive pulmonary disease (COPD) patients often exhibit gastrointestinal symptoms, A potential association between COPD and Colorectal Cancer (CRC) has been indicated, warranting further examination.

    Authors: Youtao Zhou, Zikai Lin, Shuojia Xie, Yuan Gao, Haobin Zhou, Fengzhen Chen, Yuewu Fu, Cuiyan Yang and Chuanfeng Ke
    Citation: Journal of Translational Medicine 2023 21:587
  18. As the most lethal gynecologic cancer, ovarian cancer (OV) holds the potential of being immunotherapy-responsive. However, only modest therapeutic effects have been achieved by immunotherapies such as immune c...

    Authors: Dong Yang, Mei-Han Duan, Qiu-Er Yuan, Zhi-Ling Li, Chuang-Hua Luo, Lan-Yue Cui, Li-Chao Li, Ying Xiao, Xian-Ying Zhu, Hai-Liang Zhang, Gong-Kan Feng, Guo-Chen Liu, Rong Deng, Jun-Dong Li and Xiao-Feng Zhu
    Citation: Journal of Translational Medicine 2023 21:586
  19. Lung cancer is the leading cause of cancer deaths worldwide. Despite never smokers comprising between 10 and 25% of all cases, lung cancer in never smokers (LCNS) is relatively under characterized from an etio...

    Authors: Peiyao Wang, Sophie Sun, Stephen Lam and William W. Lockwood
    Citation: Journal of Translational Medicine 2023 21:585
  20. Disasters and accidents have occurred with increasing frequency in recent years. Primary disasters have the potential to result in mass casualty events involving crush syndrome (CS) and other serious injuries....

    Authors: Daisuke Usuda, Shintaro Shimozawa, Hiroki Takami, Yoshinobu Kako, Taigo Sakamoto, Junya Shimazaki, Junichi Inoue, Shinichi Nakayama, Yuichi Koido and Jiro Oba
    Citation: Journal of Translational Medicine 2023 21:584
  21. Currently, women around the world are still suffering from various female common diseases with the high incidence, such as ovarian cancer, uterine fibroids and preeclampsia (PE), and some diseases are even wit...

    Authors: Qiang Xu, Mukun Yao and Chao Tang
    Citation: Journal of Translational Medicine 2023 21:583
  22. Over the last five decades, breast density has been associated with increased risk of developing breast cancer. Mammographically dense breasts are considered those belonging to the heterogeneously dense breast...

    Authors: Sofia M. Tarchi, Monica Pernia Marin, Md. Murad Hossain and Mary Salvatore
    Citation: Journal of Translational Medicine 2023 21:582
  23. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are seed cells that can be used for alternative treatment of myocardial damage. However, their immaturity limits their clinical applicatio...

    Authors: Huiwen Liu, Li Wang, Hao Xu, Bin Tan, Qin Yi, Hongrong Deng, Yunxia Chen, Bolin He, Jie Tian and Jing Zhu
    Citation: Journal of Translational Medicine 2023 21:581
  24. To gain deeper insights into the microenvironment of breast cancer, we utilized GeoMx Digital Spatial Profiling (DSP) technology to analyze transcripts from 107 regions of interest in 65 untreated breast cance...

    Authors: Guohong Liu, Liping Wang, Lili Ji, Dan He, Lihua Zeng, Guangzheng Zhuo, Qian Zhang, Dujuan Wang and Yunbao Pan
    Citation: Journal of Translational Medicine 2023 21:580
  25. Janus kinase 1 (JAK1) plays a critical role in most cytokine-mediated inflammatory, autoimmune responses and various cancers via the JAK/STAT signaling pathway. Inhibition of JAK1 is therefore an attractive th...

    Authors: Zixiao Wang, Lili Sun, Yu Xu, Peida Liang, Kaiyan Xu and Jing Huang
    Citation: Journal of Translational Medicine 2023 21:579
  26. Pancreatic ductal adenocarcinoma (PDAC) is expected to soon surpass colorectal cancer as a leading cause of cancer mortality in both males and females in the US, only lagging behind lung cancer. The lethality ...

    Authors: Nuno Bastos, Stéphanie A. Castaldo, Bárbara Adem, José C. Machado, Carlos A. Melo and Sonia A. Melo
    Citation: Journal of Translational Medicine 2023 21:578
  27. With metabolic alterations of the tumor microenvironment (TME) contributing to cancer progression, metastatic spread and response to targeted therapies, non-invasive and repetitive imaging of tumor metabolism ...

    Authors: Emily Hoffmann, Daniel Schache, Carsten Höltke, Jens Soltwisch, Stephan Niland, Tobias Krähling, Klaus Bergander, Martin Grewer, Christiane Geyer, Linda Groeneweg, Johannes A. Eble, Thomas Vogl, Johannes Roth, Walter Heindel, Bastian Maus, Anne Helfen…
    Citation: Journal of Translational Medicine 2023 21:577
  28. Tumor hypoxia is associated with resistance to radiotherapy and chemotherapy. In head and neck squamous cell carcinoma (HNSCC), nimorazole, an oxygen mimic, combined with radiotherapy (RT) enabled to improve l...

    Authors: Lydia Koi, Verena Bitto, Corina Weise, Lisa Möbius, Annett Linge, Steffen Löck, Ala Yaromina, María José Besso, Chiara Valentini, Manuel Pfeifer, Jens Overgaard, Daniel Zips, Ina Kurth, Mechthild Krause and Michael Baumann
    Citation: Journal of Translational Medicine 2023 21:576
  29. Benign prostatic hyperplasia (BPH) is a common disease in elderly men, mainly resulted from an imbalance between cell proliferation and death. Glutathione peroxidase 3 (GPX3) was one of the differentially expr...

    Authors: Yan Li, Yongying Zhou, Daoquan Liu, Zhen Wang, Jizhang Qiu, Junchao Zhang, Ping Chen, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E. DiSanto and Xinhua Zhang
    Citation: Journal of Translational Medicine 2023 21:575
  30. This study investigated the correlation between the expression of DARS2 and metabolic parameters of 18F-FDG PET/CT, and explored the potential mechanisms of DARS2 affecting the proliferation and glycolysis of lun...

    Authors: Xu-Sheng Liu, Ling-Ling Yuan, Yan Gao, Xing Ming, Yao-Hua Zhang, Yu Zhang, Zi-Yue Liu, Yi Yang and Zhi-Jun Pei
    Citation: Journal of Translational Medicine 2023 21:574
  31. Ankylosing spondylitis (AS) is an autoimmune disease with a genetic correlation and is characterized by inflammation in the axial skeleton and sacroiliac joints. Many AS patients also have inflammatory bowel d...

    Authors: Xinzhe Feng, Shanbang Zhu, Junjie Qiao, Zhou Ji, Bole Zhou and Weidong Xu
    Citation: Journal of Translational Medicine 2023 21:573
  32. Immunotoxins are antibody-toxin conjugates that bind to surface antigens and exert effective cytotoxic activity after internalization into tumor cells. Immunotoxins exhibit effective cytotoxicity and have been...

    Authors: Xiaoyu Liu, Qingqing Tan, Jiaqi Wen, Xufei Wang, Gang Yang, Yuxiao Li, Ming Lu, Wei Ye, Anfeng Si, Sujuan Ma, Tong Ding, Luan Sun, Fang Liu, Mei Zhang, Tao Jiang and Wei Gao
    Citation: Journal of Translational Medicine 2023 21:572
  33. Authors: Gunjan Dagar, Ashna Gupta, Tariq Masoodi, Sabah Nisar, Maysaloun Merhi, Sheema Hashem, Ravi Chauhan, Manisha Dagar, Sameer Mirza, Puneet Bagga, Rakesh Kumar, Ammira S. Al-Shabeeb Akil, Muzafar A. Macha, Mohammad Haris, Shahab Uddin, Mayank Singh…
    Citation: Journal of Translational Medicine 2023 21:571

    The original article was published in Journal of Translational Medicine 2023 21:449

  34. Breast cancer is the most common cancer affecting women across the world. Tumor endothelial cells (TECs) and malignant cells are the major constituents of the tumor microenvironment (TME), but their origin and...

    Authors: Youxue Zhang, Fang Zhen, Yue Sun, Bing Han, Hongyi Wang, Yuhang Zhang, Huaixi Zhang and Jing Hu
    Citation: Journal of Translational Medicine 2023 21:570
  35. Photoreceptor degeneration underpinned by oxidative stress-mediated mitochondrial dysfunction and cell death leads to progressive and irreversible vision impairment. Drug treatments that protect against photor...

    Authors: Daijin Li, Jing Xu, Jie Chang, Yujue Wang, Xiaoye Du, Hanhan Wu, Jingang Cui, Peiwei Wang, Teng Zhang and Yu Chen
    Citation: Journal of Translational Medicine 2023 21:569
  36. Non-alcoholic Fatty Liver Disease (NAFLD), now better known as Metabolic (Dysfunction)-Associated Fatty Liver Disease (MAFLD) and its progression to Nonalcoholic Steatohepatitis (NASH), more recently referred ...

    Authors: Paolo Convertini, Anna Santarsiero, Simona Todisco, Michele Gilio, Donatella Palazzo, Ilaria Pappalardo, Dominga Iacobazzi, Maria Frontuto and Vittoria Infantino
    Citation: Journal of Translational Medicine 2023 21:568
  37. The nucleotide-binding oligomeric domain (NOD)-like receptor protein 3 (NLRP3) inflammasome is believed to be a key mediator of neuroinflammation and subsequent secondary brain injury induced by ischemic strok...

    Authors: Yuxin Chen, Xiaohuan Li, Qian Xiong, Yehong Du, Man Luo, Lilin Yi, Yayan Pang, Xiuyu Shi, Yu Tian Wang and Zhifang Dong
    Citation: Journal of Translational Medicine 2023 21:567
  38. Long-chain acyl-carnitines (ACs) are potential arrhythmogenic metabolites. Their role in atrial fibrillation (AF) remains incompletely understood. Using a systems medicine approach, we assessed the contributio...

    Authors: Julia Krause, Alexander Nickel, Alexandra Madsen, Hamish M. Aitken-Buck, A. M. Stella Stoter, Jessica Schrapers, Francisco Ojeda, Kira Geiger, Melanie Kern, Michael Kohlhaas, Edoardo Bertero, Patrick Hofmockel, Florian Hübner, Ines Assum, Matthias Heinig, Christian Müller…
    Citation: Journal of Translational Medicine 2023 21:566
  39. Intracerebral hemorrhage (ICH) is a condition associated with high morbidity and mortality, and glia-mediated inflammation is a major contributor to neurological deficits. However, there is currently no proven...

    Authors: Wei-Shen Su, Chun-Hu Wu, Wen-Shin Song, Szu-Fu Chen and Feng-Yi Yang
    Citation: Journal of Translational Medicine 2023 21:565
  40. Myasthenia gravis (MG) is the most prevalent autoimmune disorder affecting the neuromuscular junction. A rapid deterioration in respiratory muscle can lead to a myasthenic crisis (MC), which represents a life-...

    Authors: Huahua Zhong, Xiao Huan, Rui Zhao, Manqiqige Su, Chong Yan, Jie Song, Jianying Xi, Chongbo Zhao, Feifei Luo and Sushan Luo
    Citation: Journal of Translational Medicine 2023 21:564
  41. Brachial plexus root avulsion (BPRA), a disabling peripheral nerve injury, induces substantial motoneuron death, motor axon degeneration and denervation of biceps muscles, leading to the loss of upper limb mot...

    Authors: Lin Wu, Shuangxi Chen, Bing He, Guijuan Zhou, Yan Xu, Guanghua Zhu, Juan Xie, Limin Deng, Xuanwei Wen, Sijing Li and Zijian Xiao
    Citation: Journal of Translational Medicine 2023 21:563
  42. Alpha-melanocyte stimulating hormone (α-MSH) and its receptor, melanocortin 1 receptor (MC1R), have been proposed as potential target for anti-cancer strategies in melanoma research, due to their tissue specif...

    Authors: Luigi Dall’Olmo, Nicole Papa, Nicoletta Concetta Surdo, Ilaria Marigo and Simone Mocellin
    Citation: Journal of Translational Medicine 2023 21:562
  43. Rheumatoid arthritis (RA) is an autoimmune disease that exhibits a high degree of heterogeneity, marked by unpredictable disease flares and significant variations in the response to available treatments. The l...

    Authors: Qi Wang, Qi-Chao Gao, Qi-Chuan Wang, Li Wu, Qi Yu and Pei-Feng He
    Citation: Journal of Translational Medicine 2023 21:561
  44. Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other. There is currently no sp...

    Authors: Álvaro González-Domínguez, Thalía Belmonte, Jesús Domínguez-Riscart, Pablo Ruiz-Ocaña, Inés Muela-Zarzuela, Ana Saez-Benito, Raúl Montañez-Martínez, Rosa M. Mateos and Alfonso M. Lechuga-Sancho
    Citation: Journal of Translational Medicine 2023 21:559
  45. Tumor invasiveness reflects numerous biological changes, including tumorigenesis, progression, and metastasis. To decipher the role of transcriptional regulators (TR) involved in tumor invasiveness, we perform...

    Authors: Mahesh Jethalia, Siddhi P. Jani, Michele Ceccarelli and Raghvendra Mall
    Citation: Journal of Translational Medicine 2023 21:558
  46. Limited published data suggests that absence of uplifts (minor pleasant events) is associated with clinical worsening in patients with chronic fatigue syndrome (CFS). The current study aimed to assess the rela...

    Authors: Fred Friedberg, Jenna L. Adamowicz, Patricia Bruckenthal, Maria Milazzo, Sameera Ramjan, Xiaoyue Zhang and Jie Yang
    Citation: Journal of Translational Medicine 2023 21:557

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