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  1. Content type: Research

    The clinical significance of fibroblast growth factor receptor 1 (FGFR1) protein expression in pancreatic cancer is largely unknown. In this study, we aimed investigate the clinical significance of FGFR1 expre...

    Authors: Farhan Haq, You-Na Sung, Inkeun Park, Mahmood Akhtar Kayani, Faizah Yousuf, Seung-Mo Hong and Sung-Min Ahn

    Citation: Journal of Translational Medicine 2018 16:374

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  2. Content type: Research

    Intracranial aneurysms (IAs) are dangerous because of their potential to rupture and cause deadly subarachnoid hemorrhages. Previously, we found significant RNA expression differences in circulating neutrophil...

    Authors: Vincent M. Tutino, Kerry E. Poppenberg, Lu Li, Hussain Shallwani, Kaiyu Jiang, James N. Jarvis, Yijun Sun, Kenneth V. Snyder, Elad I. Levy, Adnan H. Siddiqui, John Kolega and Hui Meng

    Citation: Journal of Translational Medicine 2018 16:373

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  3. Content type: Research

    Lung adenocarcinoma (LUAD), largely remains a primary cause of cancer-related death worldwide. The molecular mechanisms in LUAD metastasis have not been completely uncovered.

    Authors: Lifeng Li, Mengle Peng, Wenhua Xue, Zhirui Fan, Tian Wang, Jingyao Lian, Yunkai Zhai, Wenping Lian, Dongchun Qin and Jie Zhao

    Citation: Journal of Translational Medicine 2018 16:372

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  4. Content type: Review

    This systematic review and meta-analysis summarized the most recent evidence on the efficacy of intermittent energy restriction (IER) versus continuous energy restriction on weight-loss, body composition, bloo...

    Authors: Iolanda Cioffi, Andrea Evangelista, Valentina Ponzo, Giovannino Ciccone, Laura Soldati, Lidia Santarpia, Franco Contaldo, Fabrizio Pasanisi, Ezio Ghigo and Simona Bo

    Citation: Journal of Translational Medicine 2018 16:371

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  5. Content type: Research

    Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with various clinical manifestations. MicroRNAs (miRNAs) and immunometabolism are recognized as key elements in SLE pathogenesis; howeve...

    Authors: Gangqiang Guo, Huijing Wang, Xinyu Shi, Lele Ye, Kai Wu, Kangmin Lin, Sisi Ye, Baoqing Li, Huidi Zhang, Qiaoai Lin, Shuang Ye, Xiangyang Xue and Chaosheng Chen

    Citation: Journal of Translational Medicine 2018 16:370

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  6. Content type: Research

    Previously, we have demonstrated that Interleukin 13 receptor alpha 2 (IL-13Rα2) is overexpressed in approximate 78% Glioblastoma multiforme (GBM) samples. We have also demonstrated that IL-13Rα2 can serve as ...

    Authors: Rukmini Bhardwaj, Akiko Suzuki, Pamela Leland, Bharat H. Joshi and Raj K. Puri

    Citation: Journal of Translational Medicine 2018 16:369

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  7. Content type: Research

    Glioblastoma multiform (GBM) is a devastating brain tumor with maximum surgical resection, radiotherapy plus concomitant and adjuvant temozolomide (TMZ) as the standard treatment. Diverse clinicopathological a...

    Authors: Wei-Zhen Gao, Lie-Mei Guo, Tian-Qi Xu, Yu-Hua Yin and Feng Jia

    Citation: Journal of Translational Medicine 2018 16:368

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  8. Content type: Research

    Breast cancer surgeons struggle with differentiating healthy tissue from cancer at the resection margin during surgery. We report on the feasibility of using diffuse reflectance spectroscopy (DRS) for real-tim...

    Authors: Lisanne L. de Boer, Torre M. Bydlon, Frederieke van Duijnhoven, Marie-Jeanne T. F. D. Vranken Peeters, Claudette E. Loo, Gonneke A. O. Winter-Warnars, Joyce Sanders, Henricus J. C. M. Sterenborg, Benno H. W. Hendriks and Theo J. M. Ruers

    Citation: Journal of Translational Medicine 2018 16:367

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  9. Content type: Research

    Adenosine-to-inosine (A-to-I) RNA editing is catalyzed by adenosine deaminases acting on RNA (ADAR) enzymes. Recent evidence suggests that RNA editing of antizyme inhibitor 1 (AZIN1) RNA is emerging as a key epig...

    Authors: Yoshinaga Okugawa, Yuji Toiyama, Kunitoshi Shigeyasu, Akira Yamamoto, Tsunehiko Shigemori, Chengzeng Yin, Takashi Ichikawa, Hiromi Yasuda, Hiroyuki Fujikawa, Shigeyuki Yoshiyama, Junichiro Hiro, Masaki Ohi, Toshimitsu Araki, Masato Kusunoki and Ajay Goel

    Citation: Journal of Translational Medicine 2018 16:366

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  10. Content type: Research

    Deregulated inflammation and immune deficit both intricately associate with cancer initiation and progression, which have been increasingly exploited as prognostic biomarkers and therapeutic targets. Recently,...

    Authors: Pengfei Diao, Yaping Wu, Jin Li, Wei Zhang, Rong Huang, Chen Zhou, Yanling Wang and Jie Cheng

    Citation: Journal of Translational Medicine 2018 16:365

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  11. Content type: Research

    Endothelial-dependent atherosclerosis develops in a non-random pattern in regions of vessel bending and bifurcations, where blood flow exhibits disturbed flow (DF) patterns. In contrast, uniform flow (UF), nor...

    Authors: Ian C. Harding, Ronodeep Mitra, Solomon A. Mensah, Ira M. Herman and Eno E. Ebong

    Citation: Journal of Translational Medicine 2018 16:364

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  12. Content type: Research

    Multiple myeloma (MM) is the plasma cell tumor, which is characterized by clonal proliferation of tumor cells, with high risk of progression to renal impairment, bone damage and amyloidosis. Although the survi...

    Authors: Weilong Zhang, Yuansheng Lin, Xiaoni Liu, Xue He, Ye Zhang, Wei Fu, Zuozhen Yang, Ping Yang, Jing Wang, Kai Hu, Xiuru Zhang, Weiyou Liu, Xiaoliang Yuan and Hongmei Jing

    Citation: Journal of Translational Medicine 2018 16:363

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  13. Content type: Research

    Infection with the hepatitis B virus (HBV) is an independent risk factor for liver cirrhosis and hepatocellular carcinoma, polymorphisms in HLA-DQB1 play an important role in HBV infections.

    Authors: Guojin Ou, Haixia Xu, Hao Yu, Xiao Liu, Liu Yang, Xin Ji, Jue Wang and Zhong Liu

    Citation: Journal of Translational Medicine 2018 16:362

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  14. Content type: Research

    Acute myeloid leukemia can develop as myoblasts infiltrate into organs and tissues anywhere other than the bone marrow, which called extramedullary infiltration (EMI), indicating a poor prognosis. Circular RNA...

    Authors: Chengfang Lv, Lili Sun, Zhibo Guo, Huibo Li, Desheng Kong, Bingqi Xu, Leilei Lin, Tianjiao Liu, Dan Guo, Jin Zhou and Yinghua Li

    Citation: Journal of Translational Medicine 2018 16:361

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  15. Content type: Review

    The myeloproliferative neoplasms (MPN), polycythaemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) are linked by a propensity to thrombosis formation and a risk of leukaemic transf...

    Authors: Graeme Greenfield, Suzanne McPherson, Ken Mills and Mary Frances McMullin

    Citation: Journal of Translational Medicine 2018 16:360

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  16. Content type: Research

    Immunoglobulin A (IgA) and IgG are major components in human intestinal mucosal surface and sera, and IgA- or IgG-coated bacteria play a vital role in the intestinal homeostasis. However, the correlation of Ig...

    Authors: Ritian Lin, Hongwei Chen, Weigang Shu, Mingming Sun, Leilei Fang, Yanhong Shi, Zhi Pang, Wei Wu and Zhanju Liu

    Citation: Journal of Translational Medicine 2018 16:359

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  17. Content type: Research

    In order to establish the workflows required to implement a real-time process involving multi-omic analysis of patient samples to support precision-guided therapeutic intervention, a tissue acquisition and ana...

    Authors: Zahi I. Mitri, Swapnil Parmar, Brett Johnson, Annette Kolodzie, Jamie M. Keck, Max Morris, Alexander R. Guimaraes, Brooke R. Beckett, Uma Borate, Charles D. Lopez, Kathleen A. Kemmer, Joshi J. Alumkal, Tomasz M. Beer, Christopher L. Corless, Gordon B. Mills, Joe W. Gray…

    Citation: Journal of Translational Medicine 2018 16:358

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  18. Content type: Research

    Identification of miRNA-disease associations has attracted much attention recently due to the functional roles of miRNAs implicated in various biological and pathological processes. Great efforts have been mad...

    Authors: Cheng Liang, Shengpeng Yu, Ka-Chun Wong and Jiawei Luo

    Citation: Journal of Translational Medicine 2018 16:357

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  19. Content type: Research

    The androgen receptor (AR) is expressed in the majority of breast cancers and across the main breast cancer subtypes. Despite the high frequency of AR expression in breast cancer its appraisal remains controve...

    Authors: Monika Pizon, Daniel Lux, Ulrich Pachmann, Katharina Pachmann and Dorothea Schott

    Citation: Journal of Translational Medicine 2018 16:356

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  20. Content type: Research

    Cell-based therapies have shown promise for the treatment of knee osteoarthritis (OA). The current study compared exercise therapy to autologous bone marrow concentrate (BMC) and platelet products for knee OA ...

    Authors: Christopher Centeno, Mitchell Sheinkop, Ehren Dodson, Ian Stemper, Christopher Williams, Matthew Hyzy, Thomas Ichim and Michael Freeman

    Citation: Journal of Translational Medicine 2018 16:355

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  21. Content type: Review

    Aortic aneurysm (AA) is defined as an enlargement of the aorta greater than 1.5 times its normal size. Early diagnosis of AA is challenging and mortality of AA is high. Curative pharmacological treatments for ...

    Authors: Zhao Cheng, Yang-zhao Zhou, Yin Wu, Qi-ying Wu, Xiao-bo Liao, Xian-ming Fu and Xin-min Zhou

    Citation: Journal of Translational Medicine 2018 16:354

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  22. Content type: Research

    Neurogenic bowel dysfunction (NBD) is a major physical and psychological problem in patients with spinal cord injury (SCI), and gut dysbiosis is commonly occurs in SCI. Here, we document neurogenic bowel manag...

    Authors: Chao Zhang, Wenhao Zhang, Jie Zhang, Yingli Jing, Mingliang Yang, Liangjie Du, Feng Gao, Huiming Gong, Liang Chen, Jun Li, Hongwei Liu, Chuan Qin, Yanmei Jia, Jiali Qiao, Bo Wei, Yan Yu…

    Citation: Journal of Translational Medicine 2018 16:353

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  23. Content type: Research

    To date the TGF-β1 activation mediated by integrin ανβ5 during fibrosis is well-known. This process has been shown also in the heart, where cardiac fibroblasts (CF) differentiate into α-smooth muscle actin (α-...

    Authors: Gianluca Lorenzo Perrucci, Veronica Antonietta Barbagallo, Maria Corlianò, Delfina Tosi, Rosaria Santoro, Patrizia Nigro, Paolo Poggio, Gaetano Bulfamante, Federico Lombardi and Giulio Pompilio

    Citation: Journal of Translational Medicine 2018 16:352

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  24. Content type: Research

    Demineralized dentin matrix (DDM) is commonly used as a bone-graft substitute. This study measured and compared human hepatitis B viruses (HBV) DNA in fresh dentin to that of dentin processed into DDM extracte...

    Authors: Inwoong Um, Sungweon Choi, Youngkyun Kim, Kangmi Pang, Jongho Lee, Minsun Lee and Bongju Kim

    Citation: Journal of Translational Medicine 2018 16:351

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  25. Content type: Research

    Increasing evidences showed that the location of the primary tumor on the right (proximal) or left (distal) side of the colon have a prognostic/predictive value for colon cancer patients. However, the understa...

    Authors: Fabiana Tatangelo, Annabella Di Mauro, Giosuè Scognamiglio, Gabriella Aquino, Antonio Lettiero, Paolo Delrio, Antonio Avallone, Monica Cantile and Gerardo Botti

    Citation: Journal of Translational Medicine 2018 16:350

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  26. Content type: Research

    we have recently shown that Tel-eVax, a genetic vaccine targeting dog telomerase (dTERT) and based on Adenovirus (Ad)/DNA Electro-Gene-Transfer (DNA–EGT) technology can induce strong immune response and increa...

    Authors: Joseph A. Impellizeri, Alessandra Gavazza, Eliana Greissworth, Anna Crispo, Maurizio Montella, Gennaro Ciliberto, George Lubas and Luigi Aurisicchio

    Citation: Journal of Translational Medicine 2018 16:349

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  27. Content type: Research

    Research on microRNAs (miRNAs) has attracted increasingly worldwide attention over recent years as growing experimental results have made clear that miRNA correlates with masses of critical biological processe...

    Authors: Xing Chen, De-Hong Zhang and Zhu-Hong You

    Citation: Journal of Translational Medicine 2018 16:348

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  28. Content type: Research

    Dexmedetomidine (DEX) has been reported to promote tumour metastases. However the underlying mechanisms remain unclear. The purpose of this study was to investigate whether DEX promotes tumour metastasis by in...

    Authors: Xiaosan Su, Yaodong Fan, Liu Yang, Jie Huang, Fei Qiao, Yu Fang and Jun Wang

    Citation: Journal of Translational Medicine 2018 16:347

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  29. Content type: Research

    Current guidelines recommend angiotensin-converting-enzyme inhibitors (ACEI) or angiotensin-receptor blockers (ARB) or β-blockers (β-B) for secondary prevention in patients after an acute myocardial infarction...

    Authors: Xuhe Gong, Xiaosong Ding, Hui Chen and Hongwei Li

    Citation: Journal of Translational Medicine 2018 16:346

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  30. Content type: Research

    Patients with monogenic familial hypercholesterolemia (FH) have high risk for coronary artery disease (CAD). A recent FH Expert Panel suggested that FH was underdiagnosed and undertreated which needs early dia...

    Authors: Ye-Xuan Cao, Na-Qiong Wu, Di Sun, Hui-Hui Liu, Jing-Lu Jin, Sha Li, Yuan-Lin Guo, Cheng-Gang Zhu, Ying Gao, Qiu-Ting Dong, Geng Liu, Qian Dong and Jian-Jun Li

    Citation: Journal of Translational Medicine 2018 16:345

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  31. Content type: Research

    l-Fucose (Fuc), a six-deoxy hexose monosaccharide, is present endogenously in humans and animals and has a wide range of biological functions. In the present study, we aimed to examine the effect of Fuc on obes.....

    Authors: Guangyan Wu, Mengwei Niu, Wenli Tang, Jingjuan Hu, Guoquan Wei, Zhanke He, Yangping Chen, Yong Jiang and Peng Chen

    Citation: Journal of Translational Medicine 2018 16:344

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  32. Content type: Research

    The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patie...

    Authors: Luz M. Medrano, Mónica Gutiérrez-Rivas, Julià Blanco, Marcial García, María A. Jiménez-Sousa, Yolanda M. Pacheco, Marta Montero, José Antonio Iribarren, Enrique Bernal, Onofre Juan Martínez, José M. Benito, Norma Rallón and Salvador Resino

    Citation: Journal of Translational Medicine 2018 16:343

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  33. Content type: Research

    The overlapping symptoms and pathophysiological similarities between burn injury and chronic fatigue syndrome (CFS) are noteworthy. Thus, this study explores the possible association between burn injury and th...

    Authors: Shin-Yi Tsai, Cheng-Li Lin, Shou-Chuan Shih, Cheng-Wei Hsu, Kam-Hang Leong, Chien-Feng Kuo, Chon-Fu Lio, Yu-Tien Chen, Yan-Jiun Hung and Leiyu Shi

    Citation: Journal of Translational Medicine 2018 16:342

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  34. Content type: Research

    In view of the limited knowledge of plasma biomarkers relating to cancer resistance to radiotherapy, we have set up screening, training and testing stages to investigate the microRNAs (miRNAs) expression profi...

    Authors: An-Lun Li, Tao-Sang Chung, Yao-Ning Chan, Chien-Lung Chen, Shih-Chieh Lin, Yun-Ru Chiang, Chen-Huan Lin, Chi-Ching Chen and Nianhan Ma

    Citation: Journal of Translational Medicine 2018 16:341

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  35. Content type: Research

    To investigate diffusion-weighted magnetic imaging (DWI) and diffusion kurtosis magnetic imaging (DKI) for the early detection of the response to docetaxel (DTX) chemotherapy in rat epithelial ovarian cancer (...

    Authors: Su-juan Yuan, Tian-kui Qiao and Jin-Wei Qiang

    Citation: Journal of Translational Medicine 2018 16:340

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  36. Content type: Research

    Adipose-derived mesenchymal stem cell (ADMSC) therapy can promote recovery from cerebral ischemia; however, more information regarding appropriate sources of ADMSCs is required. This study was aimed at analyzi...

    Authors: Zhang Yu, Tang Wenyan, Su Xuewen, Dong Baixiang, Wang Qian, Wang Zhaoyan, Yang Yinxiang, Qu Suqing and Luan Zuo

    Citation: Journal of Translational Medicine 2018 16:339

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  37. Content type: Research

    Dysfunction of the circadian clock and polymorphisms of some circadian genes have been linked to cancer development and progression. We investigated the relationship between circadian genes germline variation ...

    Authors: Clara Benna, Senthilkumar Rajendran, Giovanna Spiro, Saveria Tropea, Paolo Del Fiore, Carlo Riccardo Rossi and Simone Mocellin

    Citation: Journal of Translational Medicine 2018 16:338

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  38. Content type: Research

    Temporal lobe epilepsy (TLE) is a common and often refractory brain disease that is closely correlated with inflammation. Alpha-methyl-l-tryptophan (AMT) is recognized as a surrogate marker for epilepsy, characte...

    Authors: Yanli Wang, Yanling Wang, Ran Sun, Xingrao Wu, Xu Chu, Shuhu Zhou, Xibin Hu, Lingyun Gao and Qingxia Kong

    Citation: Journal of Translational Medicine 2018 16:337

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  39. Content type: Review

    With the exception of genotoxic oncology drugs, first-in-human, Phase 1 clinical studies of investigational drugs have traditionally been conducted in healthy volunteers (HVs). The primary goal of these studie...

    Authors: Joyson J. Karakunnel, Nam Bui, Latha Palaniappan, Keith T. Schmidt, Kenneth W. Mahaffey, Briggs Morrison, William D. Figg and Shivaani Kummar

    Citation: Journal of Translational Medicine 2018 16:336

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  40. Content type: Research

    Recent studies have suggested a possible association between heparin treatment at the time of cell-free DNA (cfDNA) testing and a non-reportable result. However, these studies lack of proper methodology and ha...

    Authors: Yohann Dabi, Sarah Guterman, Jacques C. Jani, Alexandra Letourneau, Adèle Demain, Pascale Kleinfinger, Laurence Lohmann, Jean-Marc Costa and Alexandra Benachi

    Citation: Journal of Translational Medicine 2018 16:335

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  41. Content type: Research

    Increased systemic and local inflammation play a vital role in the pathophysiology of acute coronary syndrome. This study aimed to assess the usefulness of selected machine learning methods and hematological m...

    Authors: Konrad Pieszko, Jarosław Hiczkiewicz, Paweł Budzianowski, Janusz Rzeźniczak, Jan Budzianowski, Jerzy Błaszczyński, Roman Słowiński and Paweł Burchardt

    Citation: Journal of Translational Medicine 2018 16:334

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  42. Content type: Research

    Studies on the relationship between depression and scrub typhus are limited. We conducted a retrospective cohort study to investigate whether scrub typhus is a risk factor for depression.

    Authors: Ying-Chuan Wang, Chun-Hsiang Chiu, Cheng-Li Lin, Feng-You Lee and Kuang-Hsi Chang

    Citation: Journal of Translational Medicine 2018 16:333

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  43. Content type: Research

    The events in early HIV infection (EHI) are important determinants of disease severity and progression rate to AIDS, but the mechanisms of pathogenesis in EHI have not been fully understood. Circular RNAs (cir...

    Authors: Yue Zhang, Hui Zhang, Minghui An, Bin Zhao, Haibo Ding, Zining Zhang, Youwen He, Hong Shang and Xiaoxu Han

    Citation: Journal of Translational Medicine 2018 16:332

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  44. Content type: Research

    The ProCESS, ARISE, and ProMISe trials have failed to show that early goal-directed therapy (EGDT) reduces mortality in patients with severe sepsis and septic shock. Although lactate-guided therapy (LGT) has b...

    Authors: Xian-Fei Ding, Zi-Yue Yang, Zhen-Tao Xu, Li-Feng Li, Bo Yuan, Li-Na Guo, Le-Xin Wang, Xi Zhu and Tong-Wen Sun

    Citation: Journal of Translational Medicine 2018 16:331

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  45. Content type: Research

    While auditory neuropathy spectrum disorder (ANSD) is a heterogeneous disorder and its management quite varies depending upon the etiology, even including self-resolution, OTOF is an important molecular etiology ...

    Authors: Bong Jik Kim, Jeong Hun Jang, Jin Hee Han, Hye-Rim Park, Doo Yi Oh, Seungmin Lee, Min Young Kim, Ah Reum Kim, Chung Lee, Nayoung K. D. Kim, Woong-Yang Park, Yun-Hoon Choung and Byung Yoon Choi

    Citation: Journal of Translational Medicine 2018 16:330

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  46. Content type: Review

    Epicutaneous immunotherapy (EPIT) is a new way of allergen administration that has a high rate of adherence and safety. The aim of this manuscript is to review clinical trials on EPIT for respiratory and food ...

    Authors: Susanna Esposito, Chiara Isidori, Alessandra Pacitto, Cristina Salvatori, Laura Sensi, Franco Frati, Giuseppe Di Cara and Francesco Marcucci

    Citation: Journal of Translational Medicine 2018 16:329

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  47. Content type: Research

    Because patient-derived xenografts (PDXs) are grown in immunodeficient mouse strains, PDXs are regarded as lacking an immune microenvironment. However, whether patients’ immune cells co-exist in PDXs remains u...

    Authors: Xingxiang Pu, Ran Zhang, Li Wang, Yungchang Chen, Yi Xu, Apar Pataer, Ismail M. Meraz, Xiaoshan Zhang, Shuhong Wu, Lin Wu, Dan Su, Weimin Mao, John V. Heymach, Jack A. Roth, Stephen G. Swisher and Bingliang Fang

    Citation: Journal of Translational Medicine 2018 16:328

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  48. Content type: Research

    Hepatocellular carcinoma is a malignant tumor with a highly invasive and metastatic phenotype, and the detection of potential indicators associated with its recurrence and metastasis after surgical resection i...

    Authors: Zheng Yu, Qifeng Ou, Fan Chen, Jiong Bi, Wen Li, Jieyi Ma, Rongchang Wang and Xiaohui Huang

    Citation: Journal of Translational Medicine 2018 16:327

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  49. Content type: Research

    The prognostic impact of surgical paraaortic staging remains unclear in patients with locally advanced cervical cancer (LACC). The objective of our study was to evaluate the survival impact of surgical staging...

    Authors: Yohann Dabi, Vanille Simon, Xavier Carcopino, Sofiane Bendifallah, Lobna Ouldamer, Vincent Lavoue, Geoffroy Canlorbe, Emilie Raimond, Charles Coutant, Olivier Graesslin, Pierre Collinet, Alexandre Bricou, Emile Daraï, Cyrille Huchon, Marcos Ballester, Bassam Haddad…

    Citation: Journal of Translational Medicine 2018 16:326

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