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  1. Research

    A Yin-Yang 1/miR-30a regulatory circuit modulates autophagy in pancreatic cancer cells

    Autophagy is a highly regulated biological process that mediates the degradation of intracellular components. It is required for tumor cell metabolism and homeostasis. Yin-Yang 1 (YY1) has been reported to be ...

    Chuang Yang, Jing-Jing Zhang, Yun-Peng Peng, Yi Zhu, Ling-Di Yin, Ji-Shu Wei, Wen-Tao Gao, Kui-Rong Jiang and Yi Miao

    Journal of Translational Medicine 2017 15:211

    Published on: 19 October 2017

  2. Research

    A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma

    The mitochondrial protein p32 is a validated therapeutic target of cancer overexpressed in glioma. Therapeutic targeting of p32 with monoclonal antibody or p32-binding LyP-1 tumor-homing peptide can limit tumo...

    Venkata Yenugonda, Natsuko Nomura, Valentina Kouznetsova, Igor Tsigelny, Valentina Fogal, Elmar Nurmemmedov, Santosh Kesari and Ivan Babic

    Journal of Translational Medicine 2017 15:210

    Published on: 18 October 2017

  3. Research

    Prediction of microbe–disease association from the integration of neighbor and graph with collaborative recommendation model

    Accumulating clinical researches have shown that specific microbes with abnormal levels are closely associated with the development of various human diseases. Knowledge of microbe–disease associations can prov...

    Yu-An Huang, Zhu-Hong You, Xing Chen, Zhi-An Huang, Shanwen Zhang and Gui-Ying Yan

    Journal of Translational Medicine 2017 15:209

    Published on: 16 October 2017

  4. Research

    Association of red cell distribution width with all-cause and cardiovascular-specific mortality in African American and white adults: a prospective cohort study

    While the mortality rate is declining in the United States, the life expectancy gap among different population groups suggests a need to identify biomarkers to improve early identification of individuals at ri...

    Salman M. Tajuddin, Mike A. Nalls, Alan B. Zonderman and Michele K. Evans

    Journal of Translational Medicine 2017 15:208

    Published on: 13 October 2017

  5. Research

    Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry

    Understanding immune phenotypes and human gastric disease in situ requires an approach that leverages multiplexed immunohistochemistry (mIHC) with multispectral imaging to facilitate precise image analyses.

    Le Ying, Feng Yan, Qiaohong Meng, Xiangliang Yuan, Liang Yu, Bryan R. G. Williams, David W. Chan, Liyun Shi, Yugang Tu, Peihua Ni, Xuefeng Wang, Dakang Xu and Yiqun Hu

    Journal of Translational Medicine 2017 15:206

    Published on: 12 October 2017

  6. Meeting report

    Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge”, Napoli, November 30th 2016

    The complex interactions between the immune system and tumors lead the identification of key molecules that govern these interactions: immunotherapeutics were designed to overcome the mechanisms broken by tumo...

    Paolo A. Ascierto, Bruno Daniele, Hans Hammers, Vera Hirsh, Joseph Kim, Lisa Licitra, Rita Nanda and Sandro Pignata

    Journal of Translational Medicine 2017 15:205

    Published on: 11 October 2017

  7. Research

    Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies

    Extracellular acidosis is a condition found within the tumor microenvironment due to inadequate blood perfusion, hypoxia, and altered tumor cell metabolism. Acidosis has pleiotropic effects on malignant progre...

    Calvin R. Justus, Edward J. Sanderlin, Lixue Dong, Tianai Sun, Jen-Tsan Chi, Kvin Lertpiriyapong and Li V. Yang

    Journal of Translational Medicine 2017 15:204

    Published on: 10 October 2017

  8. Research

    A lipidated peptide of Mycobacterium tuberculosis resuscitates the protective efficacy of BCG vaccine by evoking memory T cell immunity

    The current BCG vaccine induces only short-term protection against Mycobacterium tuberculosis (Mtb), suggesting its failure to generate long-lasting memory T cells. Previously, we have demonstrated that a self-ad...

    Pradeep K. Rai, Sathi Babu Chodisetti, Weiguang Zeng, Sajid Nadeem, Sudeep K. Maurya, Susanta Pahari, Ashok K. Janmeja, David C. Jackson and Javed N. Agrewala

    Journal of Translational Medicine 2017 15:201

    Published on: 6 October 2017

  9. Research

    Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension

    Meaningful translational large animal models for cardiac diseases are indispensable for studying disease mechanisms, development of novel therapeutic strategies, and evaluation of potential drugs.

    Mariann Gyöngyösi, Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Georg Goliasch, Ljubica Mandic, Jutta Bergler-Klein, Alfred Gugerell, Andras Jakab, Zsuzsanna Szankai, Levente Toth, Rita Garamvölgyi, Gerald Maurer, Frederic Jaisser…

    Journal of Translational Medicine 2017 15:202

    Published on: 6 October 2017

  10. Research

    Impact of mesenchymal stem cells’ secretome on glioblastoma pathophysiology

    Glioblastoma (GBM) is a highly aggressive primary brain cancer, for which curative therapies are not available. An emerging therapeutic approach suggested to have potential to target malignant gliomas has been...

    Joana Vieira de Castro, Eduardo D. Gomes, Sara Granja, Sandra I. Anjo, Fátima Baltazar, Bruno Manadas, António J. Salgado and Bruno M. Costa

    Journal of Translational Medicine 2017 15:200

    Published on: 2 October 2017

  11. Meeting report

    Report on the first SLFN11 monothematic workshop: from function to role as a biomarker in cancer

    SLFN11 is a recently discovered protein with a putative DNA/RNA helicase function. First identified in association with the maturation of thymocytes, SLFN11 was later causally associated, by two independent gr...

    Alberto Ballestrero, Davide Bedognetti, Domenico Ferraioli, Paola Franceschelli, Sana Intidhar Labidi-Galy, Elisabetta Leo, Junko Murai, Yves Pommier, Petros Tsantoulis, Valerio Gaetano Vellone and Gabriele Zoppoli

    Journal of Translational Medicine 2017 15:199

    Published on: 2 October 2017

  12. Research

    Statistically controlled identification of differentially expressed genes in one-to-one cell line comparisons of the CMAP database for drug repositioning

    The Connectivity Map (CMAP) database, an important public data source for drug repositioning, archives gene expression profiles from cancer cell lines treated with and without bioactive small molecules. Howeve...

    Jun He, Haidan Yan, Hao Cai, Xiangyu Li, Qingzhou Guan, Weicheng Zheng, Rou Chen, Huaping Liu, Kai Song, Zheng Guo and Xianlong Wang

    Journal of Translational Medicine 2017 15:198

    Published on: 29 September 2017

  13. Research

    Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy

    Degenerative disc disease (DDD) is a common cause of lower back pain with radicular symptoms and has a significant socioeconomic impact given the associated disability. Limited effective conservative therapeut...

    Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Christopher J. Williams, Matthew Hyzy, Thomas Ichim and Michael Freeman

    Journal of Translational Medicine 2017 15:197

    Published on: 22 September 2017

  14. Research

    BDNF/TrkB axis activation promotes epithelial–mesenchymal transition in idiopathic pulmonary fibrosis

    Neurotrophins (NT) belongs to a family of growth factors which promotes neurons survival and differentiation. Increasing evidence show that NT and their receptor are expressed in lung tissues suggesting a poss...

    Emanuela Cherubini, Salvatore Mariotta, Davide Scozzi, Rita Mancini, Giorgia Osman, Michela D’Ascanio, Pierdonato Bruno, Giuseppe Cardillo and Alberto Ricci

    Journal of Translational Medicine 2017 15:196

    Published on: 22 September 2017

  15. Review

    p53: key conductor of all anti-acne therapies

    This review based on translational research predicts that the transcription factor p53 is the key effector of all anti-acne therapies. All-trans retinoic acid (ATRA) and isotretinoin (13-cis retinoic acid) enhanc...

    Bodo C. Melnik

    Journal of Translational Medicine 2017 15:195

    Published on: 19 September 2017

  16. Erratum

    Erratum to: Ockham’s razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer

    In the original version of this article [1], published on 2 September 2016, the name of author ‘Alice Balderacchi’ was wrongly displayed. In this Erratum the incorrect name and correct name are shown. The origina...

    Giulia M. Stella, Alessandra Gentile, Alice Balderacchi, Federica Meloni, Melissa Milan and Silvia Benvenuti

    Journal of Translational Medicine 2017 15:194

    Published on: 19 September 2017

    The original article was published in Journal of Translational Medicine 2016 14:256

  17. Erratum

    Expression of Concern to: Therapeutic potential of human embryonic stem cell transplantation in patients with cerebral palsy

    The Editor-in-Chief of the Journal of Translational Medicine is issuing an editorial expression of concern to alert readers that concerns have been raised regarding the ethics of this study [1] and the potential...

    Geeta Shroff, Anupama Gupta and Jitender Kumar Barthakur

    Journal of Translational Medicine 2017 15:193

    Published on: 18 September 2017

    The original article was published in Journal of Translational Medicine 2014 12:318

  18. Research

    Transcriptomic meta-analysis identifies gene expression characteristics in various samples of HIV-infected patients with nonprogressive disease

    A small proportion of HIV-infected patients remain clinically and/or immunologically stable for years, including elite controllers (ECs) who have undetectable viremia (<50 copies/ml) and long-term nonprogresso...

    Le-Le Zhang, Zi-Ning Zhang, Xian Wu, Yong-Jun Jiang, Ya-Jing Fu and Hong Shang

    Journal of Translational Medicine 2017 15:191

    Published on: 12 September 2017

  19. Research

    Absolute quantification of microparticles by flow cytometry in ascites of patients with decompensated cirrhosis: a cohort study

    Microparticles (MPs) are small (<1 μm) cell membrane-derived vesicles that are formed in response to cellular activation or early stages of apoptosis. Increased plasma MP levels have been associated with liver...

    Cornelius Engelmann, Katrin Splith, Sandra Krohn, Adam Herber, Albrecht Boehlig, Stephan Boehm, Johann Pratschke, Thomas Berg and Moritz Schmelzle

    Journal of Translational Medicine 2017 15:188

    Published on: 6 September 2017

  20. Research

    Over-expression of BAG-1 in head and neck squamous cell carcinomas (HNSCC) is associated with cisplatin-resistance

    In order to improve therapy for head and neck squamous cell carcinoma (HNSCC), biomarkers associated with local and/or distant tumor relapses and cancer drug resistance are urgently needed. This study identifi...

    Shutong Liu, Bo Ren, Hang Gao, Suchan Liao, Ying-Xian Zhai, Shirong Li, Xue-Jin Su, Ping Jin, David Stroncek, Zhixiang Xu, Qinghua Zeng and Yulin Li

    Journal of Translational Medicine 2017 15:189

    Published on: 6 September 2017

  21. Research

    Altered Semmes–Weinstein monofilament test results are associated with oxidative stress markers in type 2 diabetic subjects

    Different lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy. The Semmes–Weinstein monofilament (SWM) test is an efficient tool for evaluating diabeti...

    Sergio Martinez-Hervás, Mercedes Molina Mendez, José Folgado, Carmen Tormos, Pilar Ascaso, Marta Peiró, Jose T. Real and Juan F. Ascaso

    Journal of Translational Medicine 2017 15:187

    Published on: 6 September 2017

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