Articles

Identification and development of a novel 5-gene diagnostic model based on immune infiltration analysis of osteoarthritis

Osteoarthritis (OA), which is due to the progressive loss and degeneration of articular cartilage, is the leading cause of disability worldwide. Therefore, it is of great significance to explore OA biomarkers ...

Authors: YaGuang Han, Jun Wu, ZhenYu Gong, YiQin Zhou, HaoBo Li, Bo Wang and QiRong Qian

SIRT5 functions as a tumor suppressor in renal cell carcinoma by reversing the Warburg effect

The aim of this study was to investigate the biological functions and underlying mechanisms of SIRT5 in clear cell renal cell carcinoma (ccRCC).

Authors: Liu Yihan, Wang Xiaojing, Liu Ao, Zhang Chuanjie, Wang Haofei, Shen Yan and He Hongchao

Bullous pemphigoid in diabetic patients treated by gliptins: the other side of the coin

Bullous pemphigoid (BP) is the most common autoimmune bullous skin disease that affects primarily patients older than 60 years. The majority of BP cases are spontaneous, but BP can also be triggered by certain...

Authors: Karim Chouchane, Giovanni Di Zenzo, Dario Pitocco, Laura Calabrese and Clara De Simone

TRPC3, but not TRPC1, as a good therapeutic target for standalone or complementary treatment of DMD

Duchenne muscular dystrophy (DMD) is an X-linked inherited disease caused by mutations in the gene encoding dystrophin that leads to a severe and ultimately life limiting muscle-wasting condition. Recombinant ...

Authors: Anna Creisméas, Claire Gazaille, Audrey Bourdon, Marc-Antoine Lallemand, Virginie François, Marine Allais, Mireille Ledevin, Thibaut Larcher, Gilles Toumaniantz, Aude Lafoux, Corinne Huchet, Ignacio Anegon, Oumeya Adjali, Caroline Le Guiner and Bodvaël Fraysse

Influence of the trajectory of the urine output for 24 h on the occurrence of AKI in patients with sepsis in intensive care unit

Sepsis-associated acute kidney injury (S-AKI) is a common and life-threatening complication in hospitalized and critically ill patients. This condition is an independent cause of death. This study was performe...

Authors: Luming Zhang, Fengshuo Xu, Didi Han, Tao Huang, Shaojin Li, Haiyan Yin and Jun Lyu

Development of an ultra-sensitive human IL-33 biomarker assay for age-related macular degeneration and asthma drug development

Over the past decade, human Interleukin 33 (hIL-33) has emerged as a key contributor to the pathogenesis of numerous inflammatory diseases. Despite the existence of several commercial hIL-33 assays spanning mu...

Authors: Elaine Mai, Joyce Chan, Levina Goon, Braeden K. Ego, Jack Bevers, Tiffany Wong, Manda Wong, Racquel Corpuz, Hongkang Xi, Jia Wu, Kellen Schneider, Dhaya Seshasayee, Michele Grimbaldeston, Gerald Nakamura, Vahan B. Indjeian, Menno van Lookeren Campagne…

Global prevalence of myasthenia gravis and the effectiveness of common drugs in its treatment: a systematic review and meta-analysis

Myasthenia gravis is a neuromuscular autoimmune disorder characterized by weakness and disability in the voluntary muscles. There have been several preliminary studies on the epidemiology of myasthenia gravis ...

Authors: Nader Salari, Behnaz Fatahi, Yalda Bartina, Mohsen Kazeminia, Reza Fatahian, Payam Mohammadi, Shamarina Shohaimi and Masoud Mohammadi

NOX4: a potential therapeutic target for pancreatic cancer and its mechanism

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is one of the seven isoforms of NOX family, which is upregulated in pancreatic cancer cell, mouse model of pancreatic cancer and human pancr...

Authors: Yawei Bi, Xiao Lei, Ningli Chai and Enqiang Linghu

Detecting prognostic biomarkers of breast cancer by regularized Cox proportional hazards models

The successful identification of breast cancer (BRCA) prognostic biomarkers is essential for the strategic interference of BRCA patients. Recently, various methods have been proposed for exploring a small prog...

Authors: Lingyu Li and Zhi-Ping Liu

Cancer-associated fibroblasts promote oral squamous cell carcinoma progression through LOX-mediated matrix stiffness

Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment, have prominent roles in the development of solid tumors as stromal targets. However, the underlying mechanism of CAF...

Authors: Jia-Yi Zhang, Wei-Wen Zhu, Meng-Yao Wang, Run-Dong Zhai, Qiong Wang, Wei-Li Shen and Lai-Kui Liu

Association between pulse pressure, systolic blood pressure and the risk of rapid decline of kidney function among general population without hypertension: results from the China health and retirement longitudinal study (CHARLS)

Association between blood pressure (BP) and kidney function among the middle and old aged general population without hypertension remains unclear.

Authors: Huai-yu Wang, Qinqin Meng, Chao Yang, Yafeng Wang, Guilan Kong, Yaohui Zhao, Fang Wang and Luxia Zhang

Extracellular vesicles carrying miRNA-181b-5p affects the malignant progression of acute lymphoblastic leukemia

To investigate how serum extracellular vesicles (EVs)-carried miRNA-181b-5p affected the proliferation, cell cycle and apoptosis of acute lymphoblastic leukemia (ALL) cells.

Authors: Wei Yan, Li Song, Huihan Wang, Wei Yang, Liang Hu and Ying Yang

Colonization of fecal microbiota from patients with neonatal necrotizing enterocolitis exacerbates intestinal injury in germfree mice subjected to necrotizing enterocolitis-induction protocol via alterations in butyrate and regulatory T cells

Necrotizing enterocolitis (NEC) remains a life-threatening disease in neonates. Numerous studies have shown a correlation between the intestinal microbiota and NEC, but the causal link remains unclear. This study...

Authors: Yu He, Weixia Du, Sa Xiao, Benhua Zeng, Xiang She, Dong Liu, Hua Du, Luquan Li, Fang Li, Qing Ai, Junli He, Chao Song, Hong Wei, Xiaodong Zhao and Jialin Yu

Identifying and characterizing lincRNA genomic clusters reveals its cooperative functions in human cancer

Emerging evidence has revealed that some long intergenic non-coding RNAs (lincRNAs) are likely to form clusters on the same chromosome, and lincRNA genomic clusters might play critical roles in the pathophysio...

Authors: Hanxiao Zhou, Yue Gao, Xin Li, Shipeng Shang, Peng Wang, Hui Zhi, Shuang Guo, Dailin Sun, Hongjia Liu, Xia Li, Yunpeng Zhang and Shangwei Ning

TRIM38 triggers the ubiquitination and degradation of glucose transporter type 1 (GLUT1) to restrict tumor progression in bladder cancer

Loss-of-function mutations or abnormal expressions of E ubiquitin ligases contributes to tumorigenesis. TRIM38 was reported to regulate immunity, inflammatory responses or apoptosis, but its roles in tumor pro...

Authors: Xiaojing Wang, Hongchao He, Wenbin Rui, Ning Zhang, Yu Zhu and Xin Xie

Sex-related differences of early cardiac functional and proteomic alterations in a rat model of myocardial ischemia

Reduced cardiovascular risk in premenopausal women has been the focus of research in recent decades. Previous hypothesis-driven experiments have highlighted the role of sex hormones on distinct inflammatory re...

Authors: Bálint András Barta, Mihály Ruppert, Klemens Erwin Fröhlich, Miguel Cosenza-Contreras, Attila Oláh, Alex Ali Sayour, Krisztián Kovács, Gellért Balázs Karvaly, Martin Biniossek, Béla Merkely, Oliver Schilling and Tamás Radovits

Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis

Knee osteoarthritis is the most prevalent joint disease and a frequent cause of pain, functional loss and disability. Conventional treatments have demonstrated only modest clinical benefits whereas cell-based ...

Authors: José María Lamo-Espinosa, Felipe Prósper, Juan F. Blanco, Fermín Sánchez-Guijo, Mercedes Alberca, Verónica García, Margarita González-Vallinas and Javier García-Sancho

Pharmacological targeting of Tripartite Motif Containing 24 for the treatment of glioblastoma

Glioblastoma (GBM) is the most aggressive brain tumor of the central nervous system. Recent studies have reported the crucial functions of Tripartite Motif Containing 24 (TRIM24) in promoting cancer progressio...

Authors: Mingzhi Han and Yanfei Sun

LINC00491 promotes cell growth and metastasis through miR-324-5p/ROCK1 in liver cancer

LINC00491 was involved in some tumors development, but its function in liver cancer has not been reported. This study aimed to investigate LINC00491 expression and function in liver cancer progression.

Authors: Wei Wang, Tao Yang, Dongsheng Li, Yinpeng Huang, Guang Bai and Qing Li

Correction to: Effect of brain radiotherapy strategies on prognosis of patients with EGFR-mutant lung adenocarcinoma with brain metastasis

Authors: Guangchuan Deng, Yingyun Zhang, Jiaojiao Ke, Qi Wang, Hongyue Qin, Jianbin Li and Zhenxiang Li

Nationwide epidemiological characteristics of chronic fatigue syndrome in South Korea

Chronic fatigue syndrome (CFS) is a long-term disabling illness accompanied by medically unexplained fatigue. This study aimed to explore the epidemiological characteristics of CFS in South Korea.

Authors: Eun-Jin Lim, Jin-Seok Lee, Eun-Jung Lee, Seok-Ju Jeong, Ho-Young Park, Yo-Chan Ahn and Chang-Gue Son

Multi-omics approach to COVID-19: a domain-based literature review

Omics data, driven by rapid advances in laboratory techniques, have been generated very quickly during the COVID-19 pandemic. Our aim is to use omics data to highlight the involvement of specific pathways, as ...

Authors: Chiara Montaldo, Francesco Messina, Isabella Abbate, Manuela Antonioli, Veronica Bordoni, Alessandra Aiello, Fabiola Ciccosanti, Francesca Colavita, Chiara Farroni, Saeid Najafi Fard, Emanuela Giombini, Delia Goletti, Giulia Matusali, Gabriella Rozera, Martina Rueca, Alessandra Sacchi…

Serum metabolomic and lipidomic profiling identifies diagnostic biomarkers for seropositive and seronegative rheumatoid arthritis patients

Diagnosing seronegative rheumatoid arthritis (RA) can be challenging due to complex diagnostic criteria. We sought to discover diagnostic biomarkers for seronegative RA cases by studying metabolomic and lipido...

Authors: Hemi Luan, Wanjian Gu, Hua Li, Zi Wang, Lu Lu, Mengying Ke, Jiawei Lu, Wenjun Chen, Zhangzhang Lan, Yanlin Xiao, Jinyue Xu, Yi Zhang, Zongwei Cai, Shijia Liu and Wenyong Zhang

Optimization of metabolism to improve efficacy during CAR-T cell manufacturing

Chimeric antigen receptor T cell (CAR-T cell) therapy is a relatively new, effective, and rapidly evolving therapeutic for adoptive immunotherapies. Although it has achieved remarkable effect in hematological ...

Authors: Meng Zhang, Xin Jin, Rui Sun, Xia Xiong, Jiaxi Wang, Danni Xie and MingFeng Zhao

Relations of physical signs to genotype, lipid and inflammatory markers, coronary stenosis or calcification, and outcomes in patients with heterozygous familial hypercholesterolemia

Although the presence of physical signs [tendon xanthomas and/or corneal arcus (TX/CA)], are associated with the risk of coronary artery disease in patients with heterozygous familial hypercholesterolemia (HeF...

Authors: Ming-Ming Liu, Jia Peng, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Qian Dong and Jian-Jun Li

Delineation of colorectal cancer ligand-receptor interactions and their roles in the tumor microenvironment and prognosis

Immunotherapies targeting ligand-receptor interactions (LRIs) are advancing rapidly in the treatment of colorectal cancer (CRC), and LRIs also affect many aspects of CRC development. However, the pattern of LR...

Authors: Hexin Lin, Lu Xia, Jiabian Lian, Yinan Chen, Yiyi Zhang, Zhicheng Zhuang, HuaJun Cai, Jun You and Guoxian Guan

Virus infection induced pulmonary fibrosis

Pulmonary fibrosis is the end stage of a broad range of heterogeneous interstitial lung diseases and more than 200 factors contribute to it. In recent years, the relationship between virus infection and pulmon...

Authors: Wei Jie Huang and Xiao Xiao Tang

Expanding the phenotypic spectrum of mutations in LRP2: a novel candidate gene of non-syndromic familial comitant strabismus

Comitant strabismus (CS) is a heterogeneous disorder that is a major contributing factor to unilateral childhood-onset visual impairment. Studies have confirmed that genetic factors play an important role in t...

Authors: Yue Wang, Xuejuan Chen, Tao Jiang, Yayun Gu, Xiaohan Zhang, Wenwen Yuan, Andi Zhao, Rui Li, Zijin Wang, Zhibin Hu and Hu Liu

The maintained attention assessment in patients affected by Myalgic encephalomyelitis/chronic fatigue syndrome: a reliable biomarker?

The maintained attention is the cause of great functional limitations in CFS/ME, a disease that mainly affects women in the central period of life. Cognitive function is explored using the Montreal Cognitive A...

Authors: Iñigo Murga, Larraitz Aranburu, Pascual A. Gargiulo, Juan-Carlos Gómez-Esteban and José-Vicente Lafuente

From biobank and data silos into a data commons: convergence to support translational medicine

To drive translational medicine, modern day biobanks need to integrate with other sources of data (clinical, genomics) to support novel data-intensive research. Currently, vast amounts of research and clinical...

Authors: Rebecca Asiimwe, Stephanie Lam, Samuel Leung, Shanzhao Wang, Rachel Wan, Anna Tinker, Jessica N. McAlpine, Michelle M. M. Woo, David G. Huntsman and Aline Talhouk

CircSERPINA3 regulates SERPINA3-mediated apoptosis, autophagy and aerobic glycolysis of prostate cancer cells by competitively binding to MiR-653-5p and recruiting BUD13

Prostate cancer (PCa) belongs to an epithelial malignancy that occurs in the prostate gland and is the most common malignancy of the male genitourinary system. Referring to related literature, circSERPINA3 has...

Authors: Zengshu Xing, Sailian Li, Zhenxiang Liu, Chong Zhang and Zhiming Bai

Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium

Nonthyroidal Illness Syndrome (NTIS) can be detected in many critical illnesses. Recently, we demonstrated that this condition is frequently observed in COVID-19 patients too and it is correlated with the seve...

Authors: Salvatore Sciacchitano, Carlo Capalbo, Christian Napoli, Andrea Negro, Luciano De Biase, Adriano Marcolongo, Paolo Anibaldi, Valentina Salvati, Lea Petrella, Luca Merlo, Daniela Alampi, Elisa Alessandri, Chiara Loffredo, Alessandra Ulivieri, Luca Lavra, Fiorenza Magi…

Effect of fecal microbiota transplantation in patients with slow transit constipation and the relative mechanisms based on the protein digestion and absorption pathway

Fecal microbiota transplantation (FMT) is considered an effective treatment for slow transit constipation (STC); nevertheless, the mechanism remains unclear.

Authors: Lulu Xie, Chen Xu, Yadong Fan, Yuwei Li, Ying Wang, Xiaoyu Zhang, Shuang Yu, Jida Wang, Rundong Chai, Zeyu Zhao, Yutong Jin, Zhe Xu, Shuwu Zhao and Yuhong Bian

Body mass index is not associated with survival outcomes and immune-related adverse events in patients with Hodgkin lymphoma treated with the immune checkpoint inhibitor nivolumab

Overweight and obese patients with solid tumors receiving anti-programmed cell death-1 (PD-1)/PD-ligand-1(PD-L1) immune checkpoint inhibitors exhibit improved survival and higher risk of immune-related adverse ev...

Authors: Rosaria De Filippi, Fortunato Morabito, Armando Santoro, Giovanni Tripepi, Francesco D’Alò, Luigi Rigacci, Francesca Ricci, Emanuela Morelli, Pier Luigi Zinzani and Antonio Pinto

Alterations of thyroid microbiota across different thyroid microhabitats in patients with thyroid carcinoma

In recent years, the incidence rate of Thyroid carcinoma (TC) has been increasing worldwide. Thus, research on factors of TC carcinogenesis may promote TC prevention and decrease the incidence rate. There are ...

Authors: Daofeng Dai, Yan Yang, Yong Yang, Tianfeng Dang, Jiansheng Xiao, Weibin Wang, Lisong Teng, Juan Xu, Jing Ye and Hongqun Jiang

Translational signaling and systems biology

Authors: Marcello Maggiolini

Effect of brain radiotherapy strategies on prognosis of patients with EGFR-mutant lung adenocarcinoma with brain metastasis

Epidermal growth factor receptor (EGFR)-mutant lung cancers have a high risk of developing brain metastases (BM). Whole brain radiotherapy (WBRT), local radiotherapy, and WBRT + Boost are frequently used for trea...

Authors: Guangchuan Deng, Yingyun Zhang, Jiaojiao Ke, Qi Wang, Hongyue Qin, Jianbin Li and Zhenxiang Li

Analysis of changes in microbiome compositions related to the prognosis of colorectal cancer patients based on tissue-derived 16S rRNA sequences

Comparing the microbiome compositions obtained under different physiological conditions has frequently been attempted in recent years to understand the functional influence of microbiomes in the occurrence of ...

Authors: Sukjung Choi, Jongsuk Chung, Mi-La Cho, Donghyun Park and Sun Shim Choi

Phospholipase A2 group IIA correlates with circulating high-density lipoprotein cholesterol and modulates cholesterol efflux possibly through regulation of PPAR-γ/LXR-α/ABCA1 in macrophages

Secretory phospholipase A2 group IIA (sPLA2-IIA) is an independent risk factor for cardiovascular disease, but its role on high-density lipoprotein cholesterol (HDL-C) level has not been clarified. The aim of ...

Authors: Ling Liang, Qiang Xie, Changqing Sun, Yuanhui Wu, Wei Zhang and Weihua Li

A large National Institute for Health Research (NIHR) Biomedical Research Centre facilitates impactful cross-disciplinary and collaborative translational research publications and research collaboration networks: a bibliometric evaluation study

The evaluation of translational health research is important for various reasons such as the research impact assessment, research funding allocation, accountability, and strategic research policy formulation. ...

Authors: Vasiliki Kiparoglou, Laurence A. Brown, Helen McShane, Keith M. Channon and Syed Ghulam Sarwar Shah

CRISPR/Cas9-mediated TGFβRII disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells in vitro

CAR T-cell therapy has been recently unveiled as one of the most promising cancer therapies in hematological malignancies. However, solid tumors mount a profound line of defense to escape immunosurveillance by...

Authors: Khadijeh Alishah, Matthias Birtel, Elham Masoumi, Leila Jafarzadeh, Hamid Reza Mirzaee, Jamshid Hadjati, Ralf-Holger Voss, Mustafa Diken and Sedighe Asad

A two-stage genome-wide association study of radiation-induced acute toxicity in head and neck cancer

Most head and neck cancer (HNC) patients receive radiotherapy (RT) and develop toxicities. This genome-wide association study (GWAS) was designed to identify single nucleotide polymorphisms (SNPs) associated w...

Authors: Elnaz Naderi, Anne Petra Gerarda Crijns, Roel Johannes Henricus Marinus Steenbakkers, Johanna Geertruida Maria van den Hoek, Hendrika Marike Boezen, Behrooz Ziad Alizadeh and Johannes Albertus Langendijk

The tumor immune microenvironment of primary and metastatic HER2− positive breast cancers utilizing gene expression and spatial proteomic profiling

The characterization of the immune component of the tumor microenvironment (TME) of human epidermal growth factor receptor 2 positive (HER2+) breast cancer has been limited. Molecular and spatial characterizat...

Authors: Ilana Schlam, Sarah E. Church, Tyler D. Hether, Krysta Chaldekas, Briana M. Hudson, Andrew M. White, Emily Maisonet, Brent T. Harris and Sandra M. Swain

Barriers to translational research in Windsor Ontario: a survey of clinical care providers and health researchers

Translational research is an ideology focussed on streamlining the transition of novel research into clinical practice to ultimately benefit populations. Central to this approach is overcoming barriers to rese...

Authors: Justin B. Senecal, Karen Metcalfe, Kaila Wilson, Indryas Woldie and Lisa A. Porter

Correction to: An update on extra-oral bitter taste receptors

Authors: Kamila Tuzim and Agnieszka Korolczuk

CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype

Obesity is associated with chronic low-grade inflammation, contributing to an increasing prevalence of chronic metabolic diseases, such as insulin resistance, non-alcoholic fatty liver disease (NALFD), and ste...

Authors: Jingchang Ma, Wei Hu, Dongliang Zhang, Jiangang Xie, Chujun Duan, Yitian Liu, Yuling Wang, Xuexue Xu, Kun Cheng, Boquan Jin, Yuan Zhang and Ran Zhuang

Correction to: Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis

Authors: Hong-Yu Shen, Liu-Xi Shi, Lin Wang, Le-Ping Fang, Wei Xu, Ju-Qing Xu, Bo-Qiang Fan and Wei-Fei Fan

MicroRNA 146a is associated with diabetic complications in type 1 diabetic patients from the EURODIAB PCS

MicroRNA-146a-5p (miR-146a-5p) is a key regulator of inflammatory processes. Expression of miR-146a-5p is altered in target organs of diabetic complications and deficiency of miR-146a-5p has been implicated in...

Authors: Federica Barutta, Beatrice Corbetta, Stefania Bellini, Simonetta Guarrera, Giuseppe Matullo, Michela Scandella, Casper Schalkwijk, Coen D. Stehouwer, Nish Chaturvedi, Sabita S. Soedamah-Muthu, Marilena Durazzo and Gabriella Gruden

High efficiency closed-system gene transfer using automated spinoculation

Gene transfer is an important tool for cellular therapies. Lentiviral vectors are most effectively transferred into lymphocytes or hematopoietic progenitor cells using spinoculation. To enable cGMP (current Go...

Authors: Victoria Ann Remley, Jianjian Jin, Sarmila Sarkar, Larry Moses, Michaela Prochazkova, Yihua Cai, Lipei Shao, Hui Liu, Tatyana Fuksenko, Ping Jin, David F. Stroncek and Steven L. Highfill

Six splice site variations, three of them novel, in the ABO gene occurring in nine individuals with ABO subtypes

Nucleotide mutations in the ABO gene may reduce the activity of glycosyltransferase, resulting in lower levels of A or B antigen expression in red blood cells. Six known splice sites have been identified accordin...

Authors: Xiaozhen Hong, Yanling Ying, Jingjing Zhang, Shu Chen, Xianguo Xu, Ji He and Faming Zhu