Articles

Identification of immune subtypes of cervical squamous cell carcinoma predicting prognosis and immunotherapy responses

The main limitation of current immune checkpoint inhibitors (ICIs) in the treatment of cervical cancer comes from the fact that it benefits only a minority of patients. The study aims to develop a classificati...

Authors: Yimin Li, Shun Lu, Shubin Wang, Xinhao Peng and Jinyi Lang

Cannabidiol has a unique effect on global brain activity: a pharmacological, functional MRI study in awake mice

The phytocannabinoid cannabidiol (CBD) exhibits anxiolytic activity and has been promoted as a potential treatment for post-traumatic stress disorders. How does CBD interact with the brain to alter behavior? W...

Authors: Aymen H. Sadaka, Ana G. Ozuna, Richard J. Ortiz, Praveen Kulkarni, Clare T. Johnson, Heather B. Bradshaw, Bruce S. Cushing, Ai-Ling Li, Andrea G. Hohmann and Craig F. Ferris

Predicting phosphorylation sites using machine learning by integrating the sequence, structure, and functional information of proteins

Post-translational modification (PTM) is a biological process that alters proteins and is therefore involved in the regulation of various cellular activities and pathogenesis. Protein phosphorylation is an ess...

Authors: Salma Jamal, Waseem Ali, Priya Nagpal, Abhinav Grover and Sonam Grover

Publisher Correction to: Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole

An amendment to this paper has been published and can be accessed via the original article.

Authors:

eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway

Eukaryotic translation initiation factor 6 (eIF6) has a crucial function in the maturation of 60S ribosomal subunits, and it controls the initiation of protein translation. Although emerging studies indicate t...

Authors: Liping Sun, Shuguang Liu, Xiaopai Wang, Xuefeng Zheng, Ya Chen and Hong Shen

The fecal microbiota of patients with pancreatic ductal adenocarcinoma and autoimmune pancreatitis characterized by metagenomic sequencing

The fecal microbiota in pancreatic ductal adenocarcinoma (PDAC) and in autoimmune pancreatitis (AIP) patients remains largely unknown. We aimed to characterize the fecal microbiota in patients with PDAC and AI...

Authors: Wenli Zhou, De Zhang, Zhengpeng Li, Huiqing Jiang, Jingnan Li, Rongrong Ren, Xuefeng Gao, Jianfeng Li, Xin Wang, Weifeng Wang and Yunsheng Yang

Mitochondrial transplantation therapy for ischemia reperfusion injury: a systematic review of animal and human studies

Mitochondria are essential organelles that provide energy for cellular functions, participate in cellular signaling and growth, and facilitate cell death. Based on their multifactorial roles, mitochondria are ...

Authors: Kei Hayashida, Ryosuke Takegawa, Muhammad Shoaib, Tomoaki Aoki, Rishabh C. Choudhary, Cyrus E. Kuschner, Mitsuaki Nishikimi, Santiago J. Miyara, Daniel M. Rolston, Sara Guevara, Junhwan Kim, Koichiro Shinozaki, Ernesto P. Molmenti and Lance B. Becker

Mir-139-5p inhibits glioma cell proliferation and progression by targeting GABRA1

Glioma is an extremely aggressive malignant neoplasm of the central nervous system. MicroRNA (miRNA) are known to bind to specific target mRNA to regulate post-transcriptional gene expression and are, therefor...

Authors: Lei Wang, Yan Liu, Zhengtao Yu, Jianwu Gong, Zhiyong Deng, Nianjun Ren, Zhe Zhong, Hao Cai, Zhi Tang, Haofeng Cheng, Shuai Chen and Zhengwen He

Gene alterations as predictors of radiation-induced toxicity in head and neck squamous cell carcinoma

Optimizing the therapeutic ratio for radiation therapy (RT) in head and neck squamous cell carcinoma (HNSCC) is uniquely challenging owing to high rates of early and late toxicity involving nearby organs at ri...

Authors: Whitney Sumner, Xenia Ray, Leisa Sutton, Daniel Rebibo, Francesco Marincola, Parag Sanghvi, Vitali Moiseenko and Ida Deichaite

PRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemia

Prickle planar cell polarity protein 1 (PRICKLE1), a core component of the non-canonical Wnt/planar cell polarity (PCP) pathway, was recently reported to be upregulated and correlated with poor prognosis in so...

Authors: Duanfeng Jiang, Yanjuan He, Qiuyu Mo, Enyi Liu, Xin Li, Lihua Huang, Qin Zhang, Fangping Chen, Yan Li and Haigang Shao

CCL21 activation of the MALAT1/SRSF1/mTOR axis underpins the development of gastric carcinoma

As a significant cause of malignancy mortality, gastric carcinoma (GC) has been well documented to be an often-fatal diagnosis. Despite the limitations of effective therapy, immunotherapy has emerged as a prom...

Authors: Qianmei Fu, Xiaohong Tan, Huaming Tang and Jijiang Liu

METTL13 inhibits progression of clear cell renal cell carcinoma with repression on PI3K/AKT/mTOR/HIF-1α pathway and c-Myc expression

Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive type of renal malignancy. Methyltransferase like 13 (METTL13) functions as an oncogene in most of human cancers, but its function and m...

Authors: Zhuonan Liu, Tianshui Sun, Chiyuan Piao, Zhe Zhang and Chuize Kong

Correction to: Achyranthes bidentata extract exerts osteoprotective effects on steroid-induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yini Jiang, Yanqiong Zhang, Weiheng Chen, Chunfang Liu, Xiaomin Li, Danni Sun, Zhenli Liu, Ying Xu, Xia Mao, Qiuyan Guo and Na Lin

Identification of sensory and motor nerve fascicles by immunofluorescence staining after peripheral nerve injury

Inappropriate matching of motor and sensory fibers after nerve repair or nerve grafting can lead to failure of nerve recovery. Identification of motor and sensory fibers is important for the development of new...

Authors: Xijie Zhou, Jian Du, Liming Qing, Thomas Mee, Xiang Xu, Zhuoran Wang, Cynthia Xu and Xiaofeng Jia

High copy number variations, particular transcription factors, and low immunity contribute to the stemness of prostate cancer cells

Tumor metastasis is the main cause of death of cancer patients, and cancer stem cells (CSCs) is the basis of tumor metastasis. However, systematic analysis of the stemness of prostate cancer cells is still not...

Authors: Zao Dai and Ping Liu

Metabolic classification of bladder cancer based on multi-omics integrated analysis to predict patient prognosis and treatment response

Currently, no molecular classification is established for bladder cancer based on metabolic characteristics. Therefore, we conducted a comprehensive analysis of bladder cancer metabolism-related genes using mu...

Authors: Chaozhi Tang, Meng Yu, Jiakang Ma and Yuyan Zhu

Deconvolution of sarcoma methylomes reveals varying degrees of immune cell infiltrates with association to genomic aberrations

Soft-tissue sarcomas (STS) are a heterogeneous group of mesenchymal tumors for which response to immunotherapies is not well established. Therefore, it is important to risk-stratify and identify STS patients w...

Authors: Malte Simon, Sadaf S. Mughal, Peter Horak, Sebastian Uhrig, Jonas Buchloh, Bogac Aybey, Albrecht Stenzinger, Hanno Glimm, Stefan Fröhling, Benedikt Brors and Charles D. Imbusch

Correction to: Automatic identification of myopic maculopathy related imaging features in optic disc region via machine learning methods

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yuchen Du, Qiuying Chen, Ying Fan, Jianfeng Zhu, Jiangnan He, Haidong Zou, Dazhen Sun, Bowen Xin, David Feng, Michael Fulham, Xiuying Wang, Lisheng Wang and Xun Xu

Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis

The gut-brain-microbiota axis (GBMAx) coordinates bidirectional communication between the gut and brain, and is increasingly recognized as playing a central role in physiology and disease. MicroRNAs are import...

Authors: Liang Zhao, Yingze Ye, Lijuan Gu, Zhihong Jian, Creed M. Stary and Xiaoxing Xiong

mTOR regulates GPVI-mediated platelet activation

Due to mTOR (mammalian/mechanistic target of rapamycin) gene-loss mice die during embryonic development, the role of mTOR in platelets has not been evaluated using gene knockout technology.

Authors: Longsheng Wang, Gang Liu, Nannan Wu, Baiyun Dai, Shuang Han, Qiaoyun Liu, Fang Huang, Zhihua Chen, Weihong Xu, Dajing Xia and Cunji Gao

Identification of an immune classification for cervical cancer and integrative analysis of multiomics data

To understand the molecular mechanisms of the antitumour response, we analysed the immune landscape of cervical cancer to identify novel immune molecular classes.

Authors: Xintong Lyu, Guang Li and Qiao Qiao

Correction to: Total saponin from Anemone flaccida Fr. Schmidt abrogates osteoclast differentiation and bone resorption via the inhibition of RANKL-induced NF-κB, JNK and p38 MAPKs activation

An amendment to this paper has been published and can be accessed via the original article.

Authors: Xiangying Kong, Wenbin Wu, Yue Yang, Hongye Wan, Xiaomin Li, Michun Zhong, Hongyan Zhao, Xiaohui Su, Shiwei Jia, Dahong Ju and Na Lin

Therapeutic mechanisms of mesenchymal stem cells in acute respiratory distress syndrome reveal potentials for Covid-19 treatment

The mortality rate of critically ill patients with acute respiratory distress syndrome (ARDS) is 30.9% to 46.1%. The emergence of the coronavirus disease 2019 (Covid-19) has become a global issue with raising ...

Authors: Wendi Wang, Wei Lei, Lina Jiang, Siqi Gao, Shijun Hu, Zi-Gang Zhao, Chun-Yu Niu and Zhen-Ao Zhao

Correction to: Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis

An amendment to this paper has been published and can be accessed via the original article.

Authors: Neil H. Riordan, Isabela Morales, Giselle Fernández, Nicole Allen, Neal E. Fearnot, Michael E. Leckrone, Dedra Jones Markovich, Darla Mansfield, Dorita Avila, Amit N. Patel, Santosh Kesari and Jorge Paz Rodriguez

Application of stem cell-derived exosomes in ischemic diseases: opportunity and limitations

Ischemic diseases characterized by an insufficient blood flow that leads to a decrease in oxygen and nutrient uptake by cells have emerged as an important contributor to both disability and death worldwide. Up...

Authors: Majid Babaei and Jafar Rezaie

Emerging therapeutics

Authors: Gennaro Ciliberto

Seasonal rhythms of vasopressin release and aquaporin-2 excretion assure appropriate water conservation in humans

Authors: Nandu Goswami, Annarita Di Mise, Mariangela Centrone, Annamaria Russo, Marianna Ranieri, Johann Reichmuth, Bianca Brix, Natale Gaspare De Santo, Ferdinando Carlo Sasso, Grazia Tamma and Giovanna Valenti

Deconditioning does not explain orthostatic intolerance in ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome)

Orthostatic intolerance (OI) is a frequent finding in individuals with myalgic encephalomyelitis /chronic fatigue syndrome (ME/CFS). Published studies have proposed that deconditioning is an important pathophy...

Authors: C. (Linda) M. C. van Campen, Peter C. Rowe and Frans C. Visser

Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts

Scleroderma is an autoimmune disease that causes dermal fibrosis. It occurs when collagen accumulates in tissue as a result of persistent inflammation. Th17 cells and pro-inflammatory cytokines such as IL-1β,...

Authors: Jeonghyeon Moon, Seon-yeong Lee, Jeong Won Choi, A Ram Lee, Jin Hee Yoo, Su-Jin Moon, Sung-Hwan Park and Mi-La Cho

Optimizing the timing of diagnostic testing after positive findings in lung cancer screening: a proof of concept radiomics study

The timeliness of diagnostic testing after positive screening remains suboptimal because of limited evidence and methodology, leading to delayed diagnosis of lung cancer and over-examination. We propose a radi...

Authors: Zixing Wang, Ning Li, Fuling Zheng, Xin Sui, Wei Han, Fang Xue, Xiaoli Xu, Cuihong Yang, Yaoda Hu, Lei Wang, Wei Song and Jingmei Jiang

Absence of the CXCR4 antagonist EPI-X4 from pharmaceutical human serum albumin preparations

Endogenous Peptide Inhibitor of CXCR4 (EPI-X4) is a natural antagonist of the CXC chemokine receptor 4 (CXCR4). EPI-X4 is a 16-mer peptide that is released from human serum albumin (HSA) by acidic aspartic pro...

Authors: Andrea Gilg, Mirja Harms, Lia-Raluca Olari, Ann-Kathrin Urbanowitz, Halvard Bonig and Jan Münch

Genetic analysis using targeted next-generation sequencing of sporadic Chinese patients with idiopathic dilated cardiomyopathy

Inherited dilated cardiomyopathy (DCM) contributes to approximately 25% of idiopathic DCM cases, and the proportion is even higher in familial DCM patients. Most studies have focused on familial DCM, whereas t...

Authors: Mingmin Li, Shuang Xia, Lan Xu, Hong Tan, Junqing Yang, Zejia Wu, Xuyu He and Liwen Li

Identifying the functions of two biomarkers in human oligodendrocyte progenitor cell development

Human oligodendrocyte precursor cells (hOPCs) are an important source of myelinating cells for cell transplantation to treat demyelinating diseases. Myelin oligodendrocytes develop from migratory and prolifera...

Authors: Haipeng Zhou, Ying He, Zhaoyan Wang, Qian Wang, Caiyan Hu, Xiaohua Wang, Siliang Lu, Ke Li, Yinxiang Yang and Zuo Luan

A combination of the percentages of IFN-γ⁺CD4⁺T cells and granzyme B⁺CD19⁺B cells is associated with acute hepatic rejection: a case control study

T cells and B cells play a key role in alloimmune responses. We aimed to characterize the shift of T cell subsets and B cell subsets during acute hepatic rejection, and further determine whether they could ser...

Authors: Ji-Qiao Zhu, Jing Wang, Xian-Liang Li, Wen-Li Xu, Shao-cheng Lv, Xin Zhao, Ren Lang and Qiang He

The roles and mechanisms of hypoxia in liver fibrosis

Liver fibrosis occurs in response to any etiology of chronic liver injury. Lack of appropriate clinical intervention will lead to liver cirrhosis or hepatocellular carcinoma (HCC), seriously affecting the qual...

Authors: Jingyao Cai, Min Hu, Zhiyang Chen and Zeng Ling

Reovirus enhances cytotoxicity of natural killer cells against colorectal cancer via TLR3 pathway

Cetuximab has been approved for use for first-line treatment of patients with wild-type KRAS metastatic colorectal cancer (CRC). However, treatment with cetuximab has shown limited efficacy as a CRC monotherapy. ...

Authors: Shiqi Long, Yangzhuo Gu, Yuanyuan An, Xiaojin Lin, Xiaoqing Chen, Xianyao Wang, Chunxiang Liao, Weiwei Ouyang, Nianxue Wang, Zhixu He and Xing Zhao

Targeting the PI3K and MAPK pathways to improve response to HER2-targeted therapies in HER2-positive gastric cancer

Aberrant PI3K signalling is implicated in trastuzumab resistance in HER2-positive gastric cancer (GC). The role of PI3K or MEK inhibitors in sensitising HER2-positive GCs to trastuzumab or in overcoming trastu...

Authors: M. Janusz Mezynski, Angela M. Farrelly, Mattia Cremona, Aoife Carr, Clare Morgan, Julie Workman, Paul Armstrong, Jennifer McAuley, Stephen Madden, Joanna Fay, Katherine M. Sheehan, Elaine W. Kay, Ciara Holohan, Yasir Elamin, Shereen Rafee, Patrick G. Morris…

Eleven immune-gene pairs signature associated with TP53 predicting the overall survival of gastric cancer: a retrospective analysis of large sample and multicenter from public database

Growing attention have been paid to the relationship between TP53 and tumor immunophenotype, but there are still lacking enough search on the field of gastric cancer (GC).

Authors: Junyu Huo, Liqun Wu and Yunjin Zang

Expression and regulatory roles of lncRNAs in G-CIMP-low vs G-CIMP-high Glioma: an in-silico analysis

Clinically relevant glioma subtypes, such as the glioma-CpG island methylator phenotype (G-CIMP), have been defined by epigenetics. In this study, the role of long non-coding RNAs in association with the poor-...

Authors: Indrani Datta, Houtan Noushmehr, Chaya Brodie and Laila M. Poisson

Inhibition of CPT1a as a prognostic marker can synergistically enhance the antileukemic activity of ABT199

Fatty acid oxidation (FAO) provides an important source of energy to promote the growth of leukemia cells. Carnitine palmitoyltransferase 1a(CPT1a), a rate-limiting enzyme of the essential step of FAO, can fac...

Authors: Shihui Mao, Qing Ling, Jiajia Pan, Fenglin Li, Shujuan Huang, Wenle Ye, Wenwen Wei, Xiangjie Lin, Yu Qian, Yungui Wang, Xin Huang, Jiansong Huang, Jinghan Wang and Jie Jin

Impact of immediate cryopreservation on the establishment of patient derived xenografts from head and neck cancer patients

Patient-derived xenografts established from human cancers are important tools for investigating novel anti-cancer therapies. Establishing PDXs requires a significant investment and many PDXs may be used infreq...

Authors: Lindsey Abel, Arda Durmaz, Rong Hu, Colin Longhurst, Andrew M. Baschnagel, Deric Wheeler, Jacob G. Scott and Randall J. Kimple

Establishment and evaluation of a rat model of extracorporeal membrane oxygenation (ECMO) thrombosis using a 3D-printed mock-oxygenator

Extracorporeal membrane oxygenation (ECMO) research using large animals requires a significant amount of resources, slowing down the development of new means of ECMO anticoagulation. Therefore, this study deve...

Authors: Nao Umei, Angela Lai, Jennifer Miller, Suji Shin, Kalliope Roberts, Saif AI Qatarneh, Shingo Ichiba, Atsuhiro Sakamoto and Keith E. Cook

Transplantation of mesenchymal stem cells for spinal cord injury: a systematic review and network meta-analysis

Spinal cord injury (SCI) is a severe traumatic disease of the central nervous system, with a global prevalence of 236–4187 per million people. This meta-analysis aimed to evaluate the safety and efficacy of me...

Authors: Wei-can Chen, Wei-feng Liu, Yu-yan Bai, Ying-ying Zhou, Yan Zhang, Cong-mei Wang, Shu Lin and He-fan He

The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life

The intestinal barrier plays an important role in the defense against infections, and nutritional, endocrine, and immune functions. The gut microbiota playing an important role in development of the gastrointe...

Authors: Mariusz Kaczmarczyk, Ulrike Löber, Karolina Adamek, Dagmara Węgrzyn, Karolina Skonieczna-Żydecka, Damian Malinowski, Igor Łoniewski, Lajos Markó, Thomas Ulas, Sofia K. Forslund and Beata Łoniewska

The role of transcriptomic biomarkers of endometrial receptivity in personalized embryo transfer for patients with repeated implantation failure

Window of implantation (WOI) displacement is one of the endometrial origins of embryo implantation failure, especially repeated implantation failure (RIF). An accurate prediction tool for endometrial receptivi...

Authors: Aihua He, Yangyun Zou, Cheng Wan, Jing Zhao, Qiong Zhang, Zhongyuan Yao, Fen Tian, Hong Wu, Xi Huang, Jing Fu, Chunxu Hu, Yue Sun, Lan Xiao, Tianli Yang, Zhaojuan Hou, Xin Dong…

Comment on “Computer algorithm can match physicians’ decisions about blood transfusions”

Authors: Sander De Bruyne

Deregulation of IL-37 and its miRNAs modulators in sarcopenic patients after rehabilitation

sarcopenia is a highly prevalent condition in elderly individuals which is characterized by loss of muscle mass and functions; recent results showed that it is also associated with inflammation. Rehabilitation...

Authors: Francesca La Rosa, Simone Agostini, Marina Saresella, Andrea Saul Costa, Federica Piancone, Rossella Miglioli, Fabio Trecate and Mario Clerici

Phase angle and Mediterranean diet in patients with acne: Two easy tools for assessing the clinical severity of disease

Acne is a chronic, inflammatory and debilitating skin disorder. Dietary factors and nutritional status are among the exacerbating factors of acne. Phase angle (PhA), a direct measure of Bioelectrical Impedance...

Authors: Luigi Barrea, Marianna Donnarumma, Sara Cacciapuoti, Giovanna Muscogiuri, Ludovica De Gregorio, Chiara Blasio, Silvia Savastano, Annamaria Colao and Gabriella Fabbrocini

Interleukin-1 blockade with RPH-104 in patients with acute ST-elevation myocardial infarction: study design and rationale

Myocardial injury of ST-segment elevation myocardial infarction (STEMI) initiates an intense inflammatory response that contributes to further damage and is a predictor of increased risk of death or heart fail...

Authors: M. Samsonov, V. Bogin, B. W. Van Tassell and A. Abbate

Retraction Note to: Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12967-021-02852-z

Authors: Himanshu Bansal, Kristin Comella, Jerry Leon, Poonam Verma, Diwaker Agrawal, Prasad Koka and Thomas Ichim