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  1. Osteoarthritis (OA), which is due to the progressive loss and degeneration of articular cartilage, is the leading cause of disability worldwide. Therefore, it is of great significance to explore OA biomarkers ...

    Authors: YaGuang Han, Jun Wu, ZhenYu Gong, YiQin Zhou, HaoBo Li, Bo Wang and QiRong Qian

    Citation: Journal of Translational Medicine 2021 19:522

    Content type: Research

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  2. Bullous pemphigoid (BP) is the most common autoimmune bullous skin disease that affects primarily patients older than 60 years. The majority of BP cases are spontaneous, but BP can also be triggered by certain...

    Authors: Karim Chouchane, Giovanni Di Zenzo, Dario Pitocco, Laura Calabrese and Clara De Simone

    Citation: Journal of Translational Medicine 2021 19:520

    Content type: Review

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  3. Duchenne muscular dystrophy (DMD) is an X-linked inherited disease caused by mutations in the gene encoding dystrophin that leads to a severe and ultimately life limiting muscle-wasting condition. Recombinant ...

    Authors: Anna Creisméas, Claire Gazaille, Audrey Bourdon, Marc-Antoine Lallemand, Virginie François, Marine Allais, Mireille Ledevin, Thibaut Larcher, Gilles Toumaniantz, Aude Lafoux, Corinne Huchet, Ignacio Anegon, Oumeya Adjali, Caroline Le Guiner and Bodvaël Fraysse

    Citation: Journal of Translational Medicine 2021 19:519

    Content type: Research

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  4. Sepsis-associated acute kidney injury (S-AKI) is a common and life-threatening complication in hospitalized and critically ill patients. This condition is an independent cause of death. This study was performe...

    Authors: Luming Zhang, Fengshuo Xu, Didi Han, Tao Huang, Shaojin Li, Haiyan Yin and Jun Lyu

    Citation: Journal of Translational Medicine 2021 19:518

    Content type: Research

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  5. Over the past decade, human Interleukin 33 (hIL-33) has emerged as a key contributor to the pathogenesis of numerous inflammatory diseases. Despite the existence of several commercial hIL-33 assays spanning mu...

    Authors: Elaine Mai, Joyce Chan, Levina Goon, Braeden K. Ego, Jack Bevers, Tiffany Wong, Manda Wong, Racquel Corpuz, Hongkang Xi, Jia Wu, Kellen Schneider, Dhaya Seshasayee, Michele Grimbaldeston, Gerald Nakamura, Vahan B. Indjeian, Menno van Lookeren Campagne…

    Citation: Journal of Translational Medicine 2021 19:517

    Content type: Methodology

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  6. Myasthenia gravis is a neuromuscular autoimmune disorder characterized by weakness and disability in the voluntary muscles. There have been several preliminary studies on the epidemiology of myasthenia gravis ...

    Authors: Nader Salari, Behnaz Fatahi, Yalda Bartina, Mohsen Kazeminia, Reza Fatahian, Payam Mohammadi, Shamarina Shohaimi and Masoud Mohammadi

    Citation: Journal of Translational Medicine 2021 19:516

    Content type: Research

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  7. Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment, have prominent roles in the development of solid tumors as stromal targets. However, the underlying mechanism of CAF...

    Authors: Jia-Yi Zhang, Wei-Wen Zhu, Meng-Yao Wang, Run-Dong Zhai, Qiong Wang, Wei-Li Shen and Lai-Kui Liu

    Citation: Journal of Translational Medicine 2021 19:513

    Content type: Research

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  8. Association between blood pressure (BP) and kidney function among the middle and old aged general population without hypertension remains unclear.

    Authors: Huai-yu Wang, Qinqin Meng, Chao Yang, Yafeng Wang, Guilan Kong, Yaohui Zhao, Fang Wang and Luxia Zhang

    Citation: Journal of Translational Medicine 2021 19:512

    Content type: Research

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  9. Necrotizing enterocolitis (NEC) remains a life-threatening disease in neonates. Numerous studies have shown a correlation between the intestinal microbiota and NEC, but the causal link remains unclear. This study...

    Authors: Yu He, Weixia Du, Sa Xiao, Benhua Zeng, Xiang She, Dong Liu, Hua Du, Luquan Li, Fang Li, Qing Ai, Junli He, Chao Song, Hong Wei, Xiaodong Zhao and Jialin Yu

    Citation: Journal of Translational Medicine 2021 19:510

    Content type: Research

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  10. Emerging evidence has revealed that some long intergenic non-coding RNAs (lincRNAs) are likely to form clusters on the same chromosome, and lincRNA genomic clusters might play critical roles in the pathophysio...

    Authors: Hanxiao Zhou, Yue Gao, Xin Li, Shipeng Shang, Peng Wang, Hui Zhi, Shuang Guo, Dailin Sun, Hongjia Liu, Xia Li, Yunpeng Zhang and Shangwei Ning

    Citation: Journal of Translational Medicine 2021 19:509

    Content type: Research

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  11. Loss-of-function mutations or abnormal expressions of E ubiquitin ligases contributes to tumorigenesis. TRIM38 was reported to regulate immunity, inflammatory responses or apoptosis, but its roles in tumor pro...

    Authors: Xiaojing Wang, Hongchao He, Wenbin Rui, Ning Zhang, Yu Zhu and Xin Xie

    Citation: Journal of Translational Medicine 2021 19:508

    Content type: Research

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  12. Reduced cardiovascular risk in premenopausal women has been the focus of research in recent decades. Previous hypothesis-driven experiments have highlighted the role of sex hormones on distinct inflammatory re...

    Authors: Bálint András Barta, Mihály Ruppert, Klemens Erwin Fröhlich, Miguel Cosenza-Contreras, Attila Oláh, Alex Ali Sayour, Krisztián Kovács, Gellért Balázs Karvaly, Martin Biniossek, Béla Merkely, Oliver Schilling and Tamás Radovits

    Citation: Journal of Translational Medicine 2021 19:507

    Content type: Research

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  13. Knee osteoarthritis is the most prevalent joint disease and a frequent cause of pain, functional loss and disability. Conventional treatments have demonstrated only modest clinical benefits whereas cell-based ...

    Authors: José María Lamo-Espinosa, Felipe Prósper, Juan F. Blanco, Fermín Sánchez-Guijo, Mercedes Alberca, Verónica García, Margarita González-Vallinas and Javier García-Sancho

    Citation: Journal of Translational Medicine 2021 19:506

    Content type: Commentary

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  14. LINC00491 was involved in some tumors development, but its function in liver cancer has not been reported. This study aimed to investigate LINC00491 expression and function in liver cancer progression.

    Authors: Wei Wang, Tao Yang, Dongsheng Li, Yinpeng Huang, Guang Bai and Qing Li

    Citation: Journal of Translational Medicine 2021 19:504

    Content type: Research

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  15. Chronic fatigue syndrome (CFS) is a long-term disabling illness accompanied by medically unexplained fatigue. This study aimed to explore the epidemiological characteristics of CFS in South Korea.

    Authors: Eun-Jin Lim, Jin-Seok Lee, Eun-Jung Lee, Seok-Ju Jeong, Ho-Young Park, Yo-Chan Ahn and Chang-Gue Son

    Citation: Journal of Translational Medicine 2021 19:502

    Content type: Research

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  16. Omics data, driven by rapid advances in laboratory techniques, have been generated very quickly during the COVID-19 pandemic. Our aim is to use omics data to highlight the involvement of specific pathways, as ...

    Authors: Chiara Montaldo, Francesco Messina, Isabella Abbate, Manuela Antonioli, Veronica Bordoni, Alessandra Aiello, Fabiola Ciccosanti, Francesca Colavita, Chiara Farroni, Saeid Najafi Fard, Emanuela Giombini, Delia Goletti, Giulia Matusali, Gabriella Rozera, Martina Rueca, Alessandra Sacchi…

    Citation: Journal of Translational Medicine 2021 19:501

    Content type: Review

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  17. Diagnosing seronegative rheumatoid arthritis (RA) can be challenging due to complex diagnostic criteria. We sought to discover diagnostic biomarkers for seronegative RA cases by studying metabolomic and lipido...

    Authors: Hemi Luan, Wanjian Gu, Hua Li, Zi Wang, Lu Lu, Mengying Ke, Jiawei Lu, Wenjun Chen, Zhangzhang Lan, Yanlin Xiao, Jinyue Xu, Yi Zhang, Zongwei Cai, Shijia Liu and Wenyong Zhang

    Citation: Journal of Translational Medicine 2021 19:500

    Content type: Research

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  18. Chimeric antigen receptor T cell (CAR-T cell) therapy is a relatively new, effective, and rapidly evolving therapeutic for adoptive immunotherapies. Although it has achieved remarkable effect in hematological ...

    Authors: Meng Zhang, Xin Jin, Rui Sun, Xia Xiong, Jiaxi Wang, Danni Xie and MingFeng Zhao

    Citation: Journal of Translational Medicine 2021 19:499

    Content type: Review

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  19. Although the presence of physical signs [tendon xanthomas and/or corneal arcus (TX/CA)], are associated with the risk of coronary artery disease in patients with heterozygous familial hypercholesterolemia (HeF...

    Authors: Ming-Ming Liu, Jia Peng, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Qian Dong and Jian-Jun Li

    Citation: Journal of Translational Medicine 2021 19:498

    Content type: Research

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  20. Immunotherapies targeting ligand-receptor interactions (LRIs) are advancing rapidly in the treatment of colorectal cancer (CRC), and LRIs also affect many aspects of CRC development. However, the pattern of LR...

    Authors: Hexin Lin, Lu Xia, Jiabian Lian, Yinan Chen, Yiyi Zhang, Zhicheng Zhuang, HuaJun Cai, Jun You and Guoxian Guan

    Citation: Journal of Translational Medicine 2021 19:497

    Content type: Research

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  21. Pulmonary fibrosis is the end stage of a broad range of heterogeneous interstitial lung diseases and more than 200 factors contribute to it. In recent years, the relationship between virus infection and pulmon...

    Authors: Wei Jie Huang and Xiao Xiao Tang

    Citation: Journal of Translational Medicine 2021 19:496

    Content type: Review

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  22. Comitant strabismus (CS) is a heterogeneous disorder that is a major contributing factor to unilateral childhood-onset visual impairment. Studies have confirmed that genetic factors play an important role in t...

    Authors: Yue Wang, Xuejuan Chen, Tao Jiang, Yayun Gu, Xiaohan Zhang, Wenwen Yuan, Andi Zhao, Rui Li, Zijin Wang, Zhibin Hu and Hu Liu

    Citation: Journal of Translational Medicine 2021 19:495

    Content type: Research

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  23. The maintained attention is the cause of great functional limitations in CFS/ME, a disease that mainly affects women in the central period of life. Cognitive function is explored using the Montreal Cognitive A...

    Authors: Iñigo Murga, Larraitz Aranburu, Pascual A. Gargiulo, Juan-Carlos Gómez-Esteban and José-Vicente Lafuente

    Citation: Journal of Translational Medicine 2021 19:494

    Content type: Research

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  24. To drive translational medicine, modern day biobanks need to integrate with other sources of data (clinical, genomics) to support novel data-intensive research. Currently, vast amounts of research and clinical...

    Authors: Rebecca Asiimwe, Stephanie Lam, Samuel Leung, Shanzhao Wang, Rachel Wan, Anna Tinker, Jessica N. McAlpine, Michelle M. M. Woo, David G. Huntsman and Aline Talhouk

    Citation: Journal of Translational Medicine 2021 19:493

    Content type: Methodology

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  25. Prostate cancer (PCa) belongs to an epithelial malignancy that occurs in the prostate gland and is the most common malignancy of the male genitourinary system. Referring to related literature, circSERPINA3 has...

    Authors: Zengshu Xing, Sailian Li, Zhenxiang Liu, Chong Zhang and Zhiming Bai

    Citation: Journal of Translational Medicine 2021 19:492

    Content type: Research

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  26. Nonthyroidal Illness Syndrome (NTIS) can be detected in many critical illnesses. Recently, we demonstrated that this condition is frequently observed in COVID-19 patients too and it is correlated with the seve...

    Authors: Salvatore Sciacchitano, Carlo Capalbo, Christian Napoli, Andrea Negro, Luciano De Biase, Adriano Marcolongo, Paolo Anibaldi, Valentina Salvati, Lea Petrella, Luca Merlo, Daniela Alampi, Elisa Alessandri, Chiara Loffredo, Alessandra Ulivieri, Luca Lavra, Fiorenza Magi…

    Citation: Journal of Translational Medicine 2021 19:491

    Content type: Research

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  27. Fecal microbiota transplantation (FMT) is considered an effective treatment for slow transit constipation (STC); nevertheless, the mechanism remains unclear.

    Authors: Lulu Xie, Chen Xu, Yadong Fan, Yuwei Li, Ying Wang, Xiaoyu Zhang, Shuang Yu, Jida Wang, Rundong Chai, Zeyu Zhao, Yutong Jin, Zhe Xu, Shuwu Zhao and Yuhong Bian

    Citation: Journal of Translational Medicine 2021 19:490

    Content type: Research

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  28. Overweight and obese patients with solid tumors receiving anti-programmed cell death-1 (PD-1)/PD-ligand-1(PD-L1) immune checkpoint inhibitors exhibit improved survival and higher risk of immune-related adverse ev...

    Authors: Rosaria De Filippi, Fortunato Morabito, Armando Santoro, Giovanni Tripepi, Francesco D’Alò, Luigi Rigacci, Francesca Ricci, Emanuela Morelli, Pier Luigi Zinzani and Antonio Pinto

    Citation: Journal of Translational Medicine 2021 19:489

    Content type: Research

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  29. In recent years, the incidence rate of Thyroid carcinoma (TC) has been increasing worldwide. Thus, research on factors of TC carcinogenesis may promote TC prevention and decrease the incidence rate. There are ...

    Authors: Daofeng Dai, Yan Yang, Yong Yang, Tianfeng Dang, Jiansheng Xiao, Weibin Wang, Lisong Teng, Juan Xu, Jing Ye and Hongqun Jiang

    Citation: Journal of Translational Medicine 2021 19:488

    Content type: Research

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  30. Epidermal growth factor receptor (EGFR)-mutant lung cancers have a high risk of developing brain metastases (BM). Whole brain radiotherapy (WBRT), local radiotherapy, and WBRT + Boost are frequently used for trea...

    Authors: Guangchuan Deng, Yingyun Zhang, Jiaojiao Ke, Qi Wang, Hongyue Qin, Jianbin Li and Zhenxiang Li

    Citation: Journal of Translational Medicine 2021 19:486

    Content type: Research

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    The Correction to this article has been published in Journal of Translational Medicine 2021 19:503

  31. Comparing the microbiome compositions obtained under different physiological conditions has frequently been attempted in recent years to understand the functional influence of microbiomes in the occurrence of ...

    Authors: Sukjung Choi, Jongsuk Chung, Mi-La Cho, Donghyun Park and Sun Shim Choi

    Citation: Journal of Translational Medicine 2021 19:485

    Content type: Research

    Published on:

  32. Secretory phospholipase A2 group IIA (sPLA2-IIA) is an independent risk factor for cardiovascular disease, but its role on high-density lipoprotein cholesterol (HDL-C) level has not been clarified. The aim of ...

    Authors: Ling Liang, Qiang Xie, Changqing Sun, Yuanhui Wu, Wei Zhang and Weihua Li

    Citation: Journal of Translational Medicine 2021 19:484

    Content type: Research

    Published on:

  33. The evaluation of translational health research is important for various reasons such as the research impact assessment, research funding allocation, accountability, and strategic research policy formulation. ...

    Authors: Vasiliki Kiparoglou, Laurence A. Brown, Helen McShane, Keith M. Channon and Syed Ghulam Sarwar Shah

    Citation: Journal of Translational Medicine 2021 19:483

    Content type: Research

    Published on:

  34. CAR T-cell therapy has been recently unveiled as one of the most promising cancer therapies in hematological malignancies. However, solid tumors mount a profound line of defense to escape immunosurveillance by...

    Authors: Khadijeh Alishah, Matthias Birtel, Elham Masoumi, Leila Jafarzadeh, Hamid Reza Mirzaee, Jamshid Hadjati, Ralf-Holger Voss, Mustafa Diken and Sedighe Asad

    Citation: Journal of Translational Medicine 2021 19:482

    Content type: Research

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  35. Most head and neck cancer (HNC) patients receive radiotherapy (RT) and develop toxicities. This genome-wide association study (GWAS) was designed to identify single nucleotide polymorphisms (SNPs) associated w...

    Authors: Elnaz Naderi, Anne Petra Gerarda Crijns, Roel Johannes Henricus Marinus Steenbakkers, Johanna Geertruida Maria van den Hoek, Hendrika Marike Boezen, Behrooz Ziad Alizadeh and Johannes Albertus Langendijk

    Citation: Journal of Translational Medicine 2021 19:481

    Content type: Research

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  36. The characterization of the immune component of the tumor microenvironment (TME) of human epidermal growth factor receptor 2 positive (HER2+) breast cancer has been limited. Molecular and spatial characterizat...

    Authors: Ilana Schlam, Sarah E. Church, Tyler D. Hether, Krysta Chaldekas, Briana M. Hudson, Andrew M. White, Emily Maisonet, Brent T. Harris and Sandra M. Swain

    Citation: Journal of Translational Medicine 2021 19:480

    Content type: Research

    Published on:

  37. Translational research is an ideology focussed on streamlining the transition of novel research into clinical practice to ultimately benefit populations. Central to this approach is overcoming barriers to rese...

    Authors: Justin B. Senecal, Karen Metcalfe, Kaila Wilson, Indryas Woldie and Lisa A. Porter

    Citation: Journal of Translational Medicine 2021 19:479

    Content type: Research

    Published on:

  38. Obesity is associated with chronic low-grade inflammation, contributing to an increasing prevalence of chronic metabolic diseases, such as insulin resistance, non-alcoholic fatty liver disease (NALFD), and ste...

    Authors: Jingchang Ma, Wei Hu, Dongliang Zhang, Jiangang Xie, Chujun Duan, Yitian Liu, Yuling Wang, Xuexue Xu, Kun Cheng, Boquan Jin, Yuan Zhang and Ran Zhuang

    Citation: Journal of Translational Medicine 2021 19:477

    Content type: Research

    Published on:

  39. MicroRNA-146a-5p (miR-146a-5p) is a key regulator of inflammatory processes. Expression of miR-146a-5p is altered in target organs of diabetic complications and deficiency of miR-146a-5p has been implicated in...

    Authors: Federica Barutta, Beatrice Corbetta, Stefania Bellini, Simonetta Guarrera, Giuseppe Matullo, Michela Scandella, Casper Schalkwijk, Coen D. Stehouwer, Nish Chaturvedi, Sabita S. Soedamah-Muthu, Marilena Durazzo and Gabriella Gruden

    Citation: Journal of Translational Medicine 2021 19:475

    Content type: Research

    Published on:

  40. Gene transfer is an important tool for cellular therapies. Lentiviral vectors are most effectively transferred into lymphocytes or hematopoietic progenitor cells using spinoculation. To enable cGMP (current Go...

    Authors: Victoria Ann Remley, Jianjian Jin, Sarmila Sarkar, Larry Moses, Michaela Prochazkova, Yihua Cai, Lipei Shao, Hui Liu, Tatyana Fuksenko, Ping Jin, David F. Stroncek and Steven L. Highfill

    Citation: Journal of Translational Medicine 2021 19:474

    Content type: Research

    Published on:

  41. Nucleotide mutations in the ABO gene may reduce the activity of glycosyltransferase, resulting in lower levels of A or B antigen expression in red blood cells. Six known splice sites have been identified accordin...

    Authors: Xiaozhen Hong, Yanling Ying, Jingjing Zhang, Shu Chen, Xianguo Xu, Ji He and Faming Zhu

    Citation: Journal of Translational Medicine 2021 19:470

    Content type: Research

    Published on:

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