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  1. Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) induces uncontrolled and self-amplified pulmonary inflammation, and has high morbidity and mortality rates in critically ill patients. In rece...

    Authors: Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv and Wei Han

    Citation: Journal of Translational Medicine 2021 19:96

    Content type: Research

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  2. As a significant cause of cancer deaths worldwide, breast cancer continues to be a troublesome malignancy. Long non-coding RNAs (lncRNAs) have been implicated in the development of breast cancer. Abnormal meth...

    Authors: Aixia Hu, Fan Hong, Daohong Li, Yuwei Jin, Lingfei Kon, Ziguang Xu, Hui He and Qi Xie

    Citation: Journal of Translational Medicine 2021 19:95

    Content type: Research

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  3. Regimens combining pemetrexed (PEM) and immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1) or programmed death-ligand 1 (PD-L1) are widely used for the treatment of advanced non-squam...

    Authors: Issei Sumiyoshi, Takahiro Okabe, Shinsaku Togo, Haruhi Takagi, Hiroaki Motomura, Yusuke Ochi, Naoko Shimada, Mizuki Haraguchi, Rina Shibayama, Yuichi Fujimoto, Junko Watanabe, Moe Iwai, Kotaro Kadoya, Shin-ichiro Iwakami and Kazuhisa Takahashi

    Citation: Journal of Translational Medicine 2021 19:92

    Content type: Research

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  4. Midkine is a multi-functional molecule participating in a various key pathological process. We aimed to evaluate the change of midkine in sepsis and its association with angiotensin-converting enzyme (ACE) sys...

    Authors: Jing-Yuan Xu, Wei Chang, Qin Sun, Fei Peng and Yi Yang

    Citation: Journal of Translational Medicine 2021 19:91

    Content type: Research

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  5. Adult granulosa cell tumor (aGCT) is a rare type of stromal cell malignant cancer of the ovary characterized by elevated estrogen levels. aGCTs ubiquitously harbor a somatic mutation in FOXL2 gene, Cys134Trp (c.4...

    Authors: Christian Secchi, Paola Benaglio, Francesca Mulas, Martina Belli, Dwayne Stupack and Shunichi Shimasaki

    Citation: Journal of Translational Medicine 2021 19:90

    Content type: Research

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  6. The antigenicity as well as the immunogenicity of tumor associated antigens (TAAs) may need to be potentiated in order to break the immunological tolerance. To this aim, heteroclitic peptides were designed int...

    Authors: Beatrice Cavalluzzo, Concetta Ragone, Angela Mauriello, Annacarmen Petrizzo, Carmen Manolio, Andrea Caporale, Luigi Vitagliano, Menotti Ruvo, Luigi Buonaguro and Maria Tagliamonte

    Citation: Journal of Translational Medicine 2021 19:89

    Content type: Research

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  7. tRNA-derived fragments (tRFs) are 14–40-nucleotide-long, small non-coding RNAs derived from specific tRNA cleavage events with key regulatory functions in many biological processes. Many studies have shown tha...

    Authors: Qiong Xiao, Peng Gao, Xuanzhang Huang, Xiaowan Chen, Quan Chen, Xinger Lv, Yu Fu, Yongxi Song and Zhenning Wang

    Citation: Journal of Translational Medicine 2021 19:88

    Content type: Research

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  8. Autoantibody production against endogenous cellular components is pathogenic feature of systemic lupus erythematosus (SLE). Follicular helper T (TFH) cells aid in B cell differentiation into autoantibody-producin...

    Authors: Se Gwang Jang, Jaeseon Lee, Seung-Min Hong, Young-Seok Song, Min Jun Kim, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park

    Citation: Journal of Translational Medicine 2021 19:86

    Content type: Research

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  9. Hypertension (HTN), diabetes mellitus (DM), and dyslipidemia (DL) are well-known risk factors of cardiovascular disease (CVD), but not all patients develop CVDs. Studies have been limited investigating genetic...

    Authors: Youhyun Song, Ja-Eun Choi, Yu-Jin Kwon, Hyuk-Jae Chang, Jung Oh Kim, Da-Hyun Park, Jae-Min Park, Seong-Jin Kim, Ji Won Lee and Kyung-Won Hong

    Citation: Journal of Translational Medicine 2021 19:85

    Content type: Research

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  10. To identify sex specific trajectories of waist circumference (WC),triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and fasting plasma glucose (FPG) during adulthood and e...

    Authors: Noushin Sadat Ahanchi, Seyed Saeed Tamehri Zadeh, Davood Khalili, Fereidoun Azizi and Farzad Hadaegh

    Citation: Journal of Translational Medicine 2021 19:84

    Content type: Research

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  11. Although chimeric antigen receptor (CAR)-T cell therapy has been remarkably successful for haematological malignancies, its efficacy against solid tumors is limited. The combination of CAR-T cell therapy with ...

    Authors: Yajun Zhang, Pei Wang, Tengjiao Wang, Yuan Fang, Yongmei Ding and Qijun Qian

    Citation: Journal of Translational Medicine 2021 19:82

    Content type: Research

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  12. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating illness, characterised by persistent fatigue that is unrelieved by rest, in combination with a range of other disabling symptoms. T...

    Authors: Rebekah Maksoud, Cassandra Balinas, Sean Holden, Hélène Cabanas, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Journal of Translational Medicine 2021 19:81

    Content type: Review

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  13. Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are highly prevalent comorbidities in patients with Type 2 diabetes. While many of these patients eventually will need treatme...

    Authors: Victoria Svop Jensen, Christian Fledelius, Christina Zachodnik, Jesper Damgaard, Helle Nygaard, Kristina Steinicke Tornqvist, Rikke Kaae Kirk, Birgitte Martine Viuff, Erik Max Wulff, Jens Lykkesfeldt and Henning Hvid

    Citation: Journal of Translational Medicine 2021 19:80

    Content type: Research

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  14. The Sars-CoV-2 can cause severe pneumonia with multiorgan disease; thus, the identification of clinical and laboratory predictors of the progression towards severe and fatal forms of this illness is needed. He...

    Authors: Flavia Biamonte, Cirino Botta, Maria Mazzitelli, Salvatore Rotundo, Enrico Maria Trecarichi, Daniela Foti, Carlo Torti, Giuseppe Viglietto, Daniele Torella and Francesco Costanzo

    Citation: Journal of Translational Medicine 2021 19:79

    Content type: Research

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  15. Tumor mutation burden (TMB) has been associated with melanoma immunotherapy (IT) outcomes, including survival. We explored whether combining TMB with immunogenomic signatures recently identified by The Cancer ...

    Authors: Leah Morales, Danny Simpson, Robert Ferguson, John Cadley, Eduardo Esteva, Kelsey Monson, Vylyny Chat, Carlos Martinez, Jeffrey Weber, Iman Osman and Tomas Kirchhoff

    Citation: Journal of Translational Medicine 2021 19:78

    Content type: Research

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  16. Nasopharyngeal carcinoma (NPC) is one of the most common malignancy in head and neck. With the development of treatments, the prognosis has improved these years, but metastasis is still the main cause of treat...

    Authors: Hui Tian, Si Shi, Bo You, Qicheng Zhang, Miao Gu and Yiwen You

    Citation: Journal of Translational Medicine 2021 19:77

    Content type: Research

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  17. Translational research is a process of applying knowledge from basic biology and clinical trials to techniques and tools that address critical medical needs. Translational research is less explored in the Ugan...

    Authors: Richard Kwizera, Emmanuel Mande, Denis Omali, Samuel Okurut, Sheila Nabweyambo, Rose Nabatanzi, Damalie Nakanjako and David B. Meya

    Citation: Journal of Translational Medicine 2021 19:76

    Content type: Review

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  18. The 21-gene recurrence score (RS) testing can predict the prognosis for luminal breast cancer patients. Meanwhile, patients > 50 years with RS > 25 have improved survival with adjuvant chemotherapy. The curren...

    Authors: Jing Yu, Jiayi Wu, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Xiaosong Chen and Kunwei Shen

    Citation: Journal of Translational Medicine 2021 19:75

    Content type: Research

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  19. COVID-19 has spread rapidly around the world, affecting a large percentage of the population. When lifting certain mandatory measures for an economic restart, robust surveillance must be established and implem...

    Authors: Yangyang Sun, Lei Yu, Chengxi Liu, Shanting Ye, Wei Chen, Dechang Li and Weiren Huang

    Citation: Journal of Translational Medicine 2021 19:74

    Content type: Research

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  20. Neurotrophic tropomyosin receptor kinases (NTRKs) are a gene family function as oncogene or tumor suppressor gene in distinct cancers. We aimed to investigate the methylation and expression profiles and prognosti...

    Authors: Zijian Chen, Zenghong Huang, Yanxin Luo, Qi Zou, Liangliang Bai, Guannan Tang, Xiaolin Wang, Guangwen Cao, Meijin Huang, Jun Xiang and Huichuan Yu

    Citation: Journal of Translational Medicine 2021 19:73

    Content type: Research

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  21. The prevalence of metabolic syndrome (Mets) is closely related to an increased incidence of cardiovascular events. Angiopoietin-like protein 4 (ANGPTL4) is contributory to the regulation of lipid metabolism, h...

    Authors: Zhoujie Tong, Jie Peng, Hongtao Lan, Wenwen Sai, Yulin Li, Jiaying Xie, Yanmin Tan, Wei Zhang, Ming Zhong and Zhihao Wang

    Citation: Journal of Translational Medicine 2021 19:72

    Content type: Research

    Published on:

  22. Skeletal muscle aging is associated with a decline in motor function and loss of muscle mass- a condition known as sarcopenia. The underlying mechanisms that drive this pathology are associated with a failure ...

    Authors: Colin Harper, Venkatesh Gopalan and Jorming Goh

    Citation: Journal of Translational Medicine 2021 19:71

    Content type: Review

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  23. The incidence of Merkel cell carcinoma (MCC), a rare form of skin cancer with a poor prognosis, has increased in Italy in recent decades. Avelumab, an anti-programmed death ligand 1 monoclonal antibody, is app...

    Authors: Giovanni Grignani, Vanna Chiarion Sileni, Carmine Pinto, Roberta Depenni, Nicola Fazio, Luca Galli, Dario Giuffrida, Carlo Carnaghi, Domenico Ciliberto, Domenico C. Corsi, Paola Queirolo, Elena Benincasa, Filippo Venturini, Gennaro Fazzi, Nuno Costa and Paolo Antonio Ascierto

    Citation: Journal of Translational Medicine 2021 19:70

    Content type: Research

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  24. Acute kidney injury (AKI), with a high morbidity and mortality, is recognized as a risk factor for chronic kidney disease (CKD). AKI-CKD transition has been regarded as one of the most pressing unmet needs in ...

    Authors: Jinxiu Hu, Jiao Qiao, Qun Yu, Bing Liu, Junhui Zhen, Yue Liu, Qiqi Ma, Yanmei Li, Qianhui Wang, Cheng Wang and Zhimei Lv

    Citation: Journal of Translational Medicine 2021 19:69

    Content type: Research

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  25. The burden of chronic and societal diseases is affected by many risk factors that can change over time. The minimalisation of disease-associated risk factors may contribute to long-term health. Therefore, new ...

    Authors: Eva Kriegova, Milos Kudelka, Martin Radvansky and Jiri Gallo

    Citation: Journal of Translational Medicine 2021 19:68

    Content type: Research

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  26. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12967-016-0831-y.

    Authors: Hsing-Chun Kuo, Chien-Chang Lu, Chien-Heng Shen, Shui-Yi Tung, Meng Chiao Hsieh, Ko-Chao Lee, Li-Ya Lee, Chin-Chu Chen, Chih-Chuan Teng, Wen-Shih Huang, Te-Chuan Chen and Kam-Fai Lee

    Citation: Journal of Translational Medicine 2021 19:67

    Content type: Retraction Note

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    The original article was published in Journal of Translational Medicine 2016 14:78

  27. Microbes are closely related to human health and diseases. Identification of disease-related microbes is of great significance for revealing the pathological mechanism of human diseases and understanding the i...

    Authors: Da Xu, Hanxiao Xu, Yusen Zhang, Mingyi Wang, Wei Chen and Rui Gao

    Citation: Journal of Translational Medicine 2021 19:66

    Content type: Research

    Published on:

  28. Rho GTPase activating protein 9 (ARHGAP9) is expressed in various types of cancers and can inactivate Rho GTPases that mainly regulate cytoskeletal dynamics. However, the exact role of ARHGAP9 in acute myeloid...

    Authors: Caixia Han, Shujiao He, Ruiqi Wang, Xuefeng Gao, Hong Wang, Jingqiao Qiao, Xiangyu Meng, Yonghui Li and Li Yu

    Citation: Journal of Translational Medicine 2021 19:65

    Content type: Research

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  29. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xingwang Zhao, Longlong Zhang, Juan Wang, Min Zhang, Zhiqiang Song, Bing Ni and Yi You

    Citation: Journal of Translational Medicine 2021 19:64

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2021 19:35

  30. Atherosclerosis is a chronic vascular disease posing a great threat to public health. We investigated whether rosuvastatin (RVS) enhanced autophagic activities to inhibit lipid accumulation and polarization co...

    Authors: Xinxin Zhang, Yating Qin, Xiaoning Wan, Hao Liu, Chao Lv, Weibin Ruan, Lin He, Li Lu and Xiaomei Guo

    Citation: Journal of Translational Medicine 2021 19:62

    Content type: Research

    Published on:

  31. The purpose of this study was to investigate the utility of BNP, hsTroponin-I, interleukin-6, sST2, and galectin-3 in predicting the future development of new onset heart failure with preserved ejection fracti...

    Authors: Chris J. Watson, Joe Gallagher, Mark Wilkinson, Adam Russell-Hallinan, Isaac Tea, Stephanie James, James O’Reilly, Eoin O’Connell, Shuaiwei Zhou, Mark Ledwidge and Ken McDonald

    Citation: Journal of Translational Medicine 2021 19:61

    Content type: Research

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  32. Studies of molecular mechanisms underlying tumor cell signaling highlighted a critical role for kinases in carcinogenesis and cancer progression. To this regard, protein kinases regulates a number of critical ...

    Authors: Francesca Benedetti, Sabrina Curreli, Robert C. Gallo and Davide Zella

    Citation: Journal of Translational Medicine 2021 19:60

    Content type: Research

    Published on:

  33. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12967-021-02719-3

    Authors: Xin Gou, Jing Wu, Mingqing Huang, Yuting Weng, Tongxin Yang, Tao Chen, Guiqing Li and Kewei Fang

    Citation: Journal of Translational Medicine 2021 19:59

    Content type: Retraction Note

    Published on:

    The original article was published in Journal of Translational Medicine 2020 18:284

  34. Copy number variation (CNV) suggests genetic changes in malignant tumors. Abnormal expressions of long non-coding RNAs (lncRNAs) resulted from genomic and epigenetic abnormalities play a driving role in tumori...

    Authors: Qihang Zhong, Minzhen Lu, Wanqiong Yuan, Yueyi Cui, Hanqiang Ouyang, Yong Fan, Zhaohui Wang, Congying Wu, Jie Qiao and Jing Hang

    Citation: Journal of Translational Medicine 2021 19:58

    Content type: Research

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  35. Melanoma is the deadliest of skin cancers and has an increasing annual incidence worldwide. It is a multi-factorial disease most likely arising from both genetic predisposition and environmental exposure to ul...

    Authors: Clara Benna, Senthilkumar Rajendran, Giovanna Spiro, Chiara Menin, Luigi Dall’Olmo, Carlo Riccardo Rossi and Simone Mocellin

    Citation: Journal of Translational Medicine 2021 19:57

    Content type: Research

    Published on:

  36. Clinical risk scores and machine learning models based on routine laboratory values could assist in automated early identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients at ri...

    Authors: Verena Schöning, Evangelia Liakoni, Christine Baumgartner, Aristomenis K. Exadaktylos, Wolf E. Hautz, Andrew Atkinson and Felix Hammann

    Citation: Journal of Translational Medicine 2021 19:56

    Content type: Research

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  37. The vast majority of good science and excellent ideas do not translate into products. Many good products that have the potential to assist in diagnosis and therapy do not mature into everyday care. This often ...

    Authors: Yaron Ilan

    Citation: Journal of Translational Medicine 2021 19:55

    Content type: Review

    Published on:

  38. Long-term high fat (HF) diet intake can cause neuroinflammation and cognitive decline through the gut-brain axis. (1, 3)/(1, 6)-β-glucan, an edible polysaccharide isolated from medical mushroom, Lentinula edodes ...

    Authors: Wei Pan, Pengfei Jiang, Jinxiu Zhao, Hongli Shi, Peng Zhang, Xiaoying Yang, Joanna Biazik, Minmin Hu, Hui Hua, Xing Ge, Xu-Feng Huang and Yinghua Yu

    Citation: Journal of Translational Medicine 2021 19:54

    Content type: Research

    Published on:

  39. One of the most prevalent causes of fetal hypoxia leading to stillbirth is placental insufficiency. Hemodynamic changes evaluated with Doppler ultrasound have been used as a surrogate marker of fetal hypoxia. ...

    Authors: Laura Pla, Sergio Berdún, Mònica Mir, Lourders Rivas, Sandrine Miserere, Samuel Dulay, Josep Samitier, Elisenda Eixarch, Miriam Illa and Eduard Gratacós

    Citation: Journal of Translational Medicine 2021 19:53

    Content type: Research

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  40. Interleukin-33 (IL-33) plays a pivotal role in regulating innate immune response and metabolic homeostasis. However, whether its circulating level is correlated with obesity and metabolic disorders in humans r...

    Authors: Haoneng Tang, Ning Liu, Xiaojing Feng, Yanyi Yang, Yiyuan Fang, Siqi Zhuang, Yufeng Dai, Meilian Liu and Lingli Tang

    Citation: Journal of Translational Medicine 2021 19:52

    Content type: Research

    Published on:

  41. Currently, there is no reliable blood-based marker to track tumor recurrence in endometrial cancer (EC) patients. Liquid biopsies, specifically, circulating tumor DNA (ctDNA) analysis emerged as a way to monit...

    Authors: Weiwei Feng, Nan Jia, Haining Jiao, Jun Chen, Yan Chen, Yueru Zhang, Menghan Zhu, Chongying Zhu, Lifei Shen and Wenqing Long

    Citation: Journal of Translational Medicine 2021 19:51

    Content type: Research

    Published on:

  42. Thoracic aortic aneurysm (TAA) can be life-threatening due to the progressive weakening and dilatation of the aortic wall. Once the aortic wall has ruptured, no effective pharmaceutical therapies are available...

    Authors: Chuxiang Lei, Dan Yang, Wenlin Chen, Haoxuan Kan, Fang Xu, Hui Zhang, Wei Wang, Lei Ji and Yuehong Zheng

    Citation: Journal of Translational Medicine 2021 19:49

    Content type: Research

    Published on:

  43. Chronic fatigue syndrome (CFS) is defined according to subjective symptoms only, and several conflicting case definition exist. Previous research has discovered certain biological alterations. The aim of the p...

    Authors: Tarjei Tørre Asprusten, Line Sletner and Vegard Bruun Bratholm Wyller

    Citation: Journal of Translational Medicine 2021 19:48

    Content type: Research

    Published on:

  44. Recent preclinical data suggest that there may be therapeutic synergy between immune checkpoint blockade and inhibition of the coagulation cascade. Here, we investigate whether patients who received immune che...

    Authors: Paul Johannet, Amelia Sawyers, Nicholas Gulati, Douglas Donnelly, Samuel Kozloff, Yingzhi Qian, Alfredo Floristan, Eva Hernando, Judy Zhong and Iman Osman

    Citation: Journal of Translational Medicine 2021 19:47

    Content type: Research

    Published on:

  45. Current diagnostic blood tests for prostate cancer (PCa) are unreliable for the early stage disease, resulting in numerous unnecessary prostate biopsies in men with benign disease and false reassurance of nega...

    Authors: Heba Alshaker, Robert Mills, Ewan Hunter, Matthew Salter, Aroul Ramadass, Benjamin Matthew Skinner, Willem Westra, Jayne Green, Alexandre Akoulitchev, Mathias Winkler and Dmitri Pchejetski

    Citation: Journal of Translational Medicine 2021 19:46

    Content type: Research

    Published on:

  46. Colorectal cancer (CRC) is a common malignant tumor globally. Meanwhile, LINC01116 has been proposed as risk factor for various tumors, including CRC. But the regulation of LINC01116 in CRC required more valid...

    Authors: Weijie Liang, Jie Wu and Xinguang Qiu

    Citation: Journal of Translational Medicine 2021 19:45

    Content type: Research

    Published on:

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