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  1. Many patients who recovered from COVID are still suffering from pulmonary dysfunction that can be persistent even for months after infection. Therefore, treatment to prevent irreversible impairment of lung fun...

    Authors: Evgeny Bazdyrev, Maria Panova, Maria Brachs, Elena Smolyarchuk, Daria Tsygankova, Liudmila Gofman, Yana Abdyusheva and Fedor Novikov
    Citation: Journal of Translational Medicine 2022 20:506
  2. Apparent mineralocorticoid excess is an autosomal recessive form of monogenic disease characterized by juvenile resistant low-renin hypertension, marked hypokalemic alkalosis, low aldosterone levels, and high ...

    Authors: Yi-ting Lu, Di Zhang, Qiong-yu Zhang, Ze-ming Zhou, Kun-qi Yang, Xian-liang Zhou and Fan Peng
    Citation: Journal of Translational Medicine 2022 20:500
  3. This paper aimed to examine the effects of probiotics on eight factors in the prediabetic population by meta-analysis, namely, fasting blood glucose (FBG), glycated haemoglobin A1c (HbA1c), homeostatic model a...

    Authors: Ya Li, You Wu, Lili Wu, Lingling Qin and Tonghua Liu
    Citation: Journal of Translational Medicine 2022 20:498
  4. To explore the roles of Annexin A2 (ANXA2) on hepatocyte pyroptosis and hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and underlying molecular mechanism.

    Authors: Yun Feng, Wenhua Li, Zhuoya Wang, Ruling Zhang, Yan Li, Lijuan Zang, Peiwen Wang, Zhenghong Li and Yuwei Dong
    Citation: Journal of Translational Medicine 2022 20:497
  5. Aberrant sialoglycans on the surface of tumor cells shield potential tumor antigen epitopes, escape recognition, and suppress activation of immunocytes. α2,3/α2,6Gal- and α2,6GalNAc (Gal/GalNAc)-linked sialic ...

    Authors: Jianmei Huang, Meiying Li, Bingjie Mei, Junyang Li, Yi Zhu, Qiaoshan Guo, Jianming Huang and Guonan Zhang
    Citation: Journal of Translational Medicine 2022 20:496
  6. Obesity (waist circumference, body mass index (BMI)) and lifestyle factors (dietary habits, smoking, alcohol drinking, Sedentary behavior) have been associated with risk of benign prostatic hyperplasia (BPH) i...

    Authors: Yong-Bo Wang, Lan Yang, Yu-Qing Deng, Si-Yu Yan, Li-Sha Luo, Ping Chen and Xian-Tao Zeng
    Citation: Journal of Translational Medicine 2022 20:495
  7. Small peptides encoded by long non-coding RNAs (lncRNAs) have attracted attention for their various functions. Recent studies indicate that these small peptides participate in immune responses and antigen pres...

    Authors: Wenbo Zhao, Yibo Wu, Feihu Zhao, Zhiyi Xue, Wenyu Liu, Zenxin Cao, Zhimin Zhao, Bin Huang, Mingzhi Han and Xingang Li
    Citation: Journal of Translational Medicine 2022 20:494
  8. Colorectal cancer (CRC) is one of the most commonly diagnosed human malignancies. Ribosomal protein L31 (RPL31, aka eL31) is a component of the 60S large ribosomal subunit, and its expression pattern and funct...

    Authors: Gaowa Sharen, Xiongfeng Li, Jiaxin Sun, Lei Zhang, Wen Xi, Xiaodong Zhao, Fei Han, Longlong Jia, Rong A, Haidong Cheng and Mingxing Hou
    Citation: Journal of Translational Medicine 2022 20:493
  9. N6-methyladenosine (m6A) related long noncoding RNAs (lncRNAs) may have prognostic value in bladder cancer for their key role in tumorigenesis and innate immunity.

    Authors: Zi-Hao Feng, Yan-Ping Liang, Jun-Jie Cen, Hao-Hua Yao, Hai-Shan Lin, Jia-Ying Li, Hui Liang, Zhu Wang, Qiong Deng, Jia-Zheng Cao, Yong Huang, Jin-Huan Wei, Jun-Hang Luo, Wei Chen and Zhen-Hua Chen
    Citation: Journal of Translational Medicine 2022 20:492
  10. Exosomes are deemed to be an important tool of intercellular communicators in cancer cells. Our study investigated the role of PRR34 long non-coding RNA antisense RNA 1 (PRR34-AS1) in regulating exosome secret...

    Authors: Zhilei Zhang, Ye Zhou, Yuming Jia, Chao Wang, Meng Zhang and Zhuo Xu
    Citation: Journal of Translational Medicine 2022 20:491
  11. Osteoporosis (OP) is a systemic bone disease characterized by the decreased bone mass and destruction of bone microstructure, which tends to result in the enhanced bone fragility and related fractures, as well...

    Authors: Yuan-Wei Zhang, Mu-Min Cao, Ying-Juan Li, Xiang-Xu Chen, Qian Yu and Yun-Feng Rui
    Citation: Journal of Translational Medicine 2022 20:490
  12. The development of permanent disability in multiple sclerosis (MS) is highly variable among patients, and the exact mechanisms that contribute to this disability remain unknown.

    Authors: Marlene Tahedl, Seth M. Levine, Robert Weissert, Zacharias Kohl, De-Hyung Lee, Ralf A. Linker and Jens V. Schwarzbach
    Citation: Journal of Translational Medicine 2022 20:488
  13. Catechol-O-methyltransferase (COMT) has been shown to influence clinical pain, descending modulation, and exercise-induced symptom worsening. COMT regulates nociceptive processing and inflammation, key pathoph...

    Authors: Andrea Polli, Jolien Hendrix, Kelly Ickmans, Jelena Bakusic, Manosij Ghosh, Dora Monteyne, Brigitte Velkeniers, Bram Bekaert, Jo Nijs and Lode Godderis
    Citation: Journal of Translational Medicine 2022 20:487
  14. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating condition that can lead to severe impairment of physical, psychological, cognitive, social, and occupational functions. The cause o...

    Authors: Zheng Wang, Michelle F. Waldman, Tara J. Basavanhally, Aviva R. Jacobs, Gonzalo Lopez, Regis Y. Perichon, Johnny J. Ma, Elyse M. Mackenzie, James B. Healy, Yixin Wang and Sarah A. Hersey
    Citation: Journal of Translational Medicine 2022 20:486
  15. Hepatocellular carcinoma (HCC) is one of the most common and malignant tumors in the digestive tract. Tumor Suppressor Candidate 3 (TUSC3) is one subunit of the endoplasmic reticulum Oligosaccharyl transferase...

    Authors: Ruxia Deng, Xiansheng Lu, Chang Hong, Rui Cai, Ping Wang, Le Xiong, Xiaoyu Wang, Qiaoyu Chen and Jie Lin
    Citation: Journal of Translational Medicine 2022 20:485
  16. Evidence about the relationship between triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and prediabetes (Pre-DM) in Chinese non-obese people with a normal range of low-density lipoprotein...

    Authors: Liling Wu, Xiaodan Wu, Haofei Hu and Qijun Wan
    Citation: Journal of Translational Medicine 2022 20:484
  17. Metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD), are rising in both incidence and prevalence and remain a major global health and socioeconomic burden in the twent...

    Authors: Yifei Chen, Fuji Yang, Ying Chu, Zhihua Yun, Yongmin Yan and Jianhua Jin
    Citation: Journal of Translational Medicine 2022 20:483
  18. DNA ligases are crucial for DNA repair and cell replication since they catalyze the final steps in which DNA breaks are joined. DNA Ligase III (LIG3) exerts a pivotal role in Alternative-Non-Homologous End Joi...

    Authors: Daniele Caracciolo, Giada Juli, Caterina Riillo, Adriana Coricello, Francesca Vasile, Sara Pollastri, Roberta Rocca, Francesca Scionti, Nicoletta Polerà, Katia Grillone, Mariamena Arbitrio, Nicoletta Staropoli, Basilio Caparello, Domenico Britti, Giovanni Loprete, Giosuè Costa…
    Citation: Journal of Translational Medicine 2022 20:482
  19. To identify novel DNA methylation-regulated differentially expressed genes (MeDEGs) in RA by integrated analysis of DNA methylation and RNA-Seq data.

    Authors: Runrun Zhang, Cen Chang, Yehua Jin, LingXia Xu, Ping Jiang, Kai Wei, Linshuai Xu, Shicheng Guo, Songtao Sun and Dongyi He
    Citation: Journal of Translational Medicine 2022 20:481
  20. Proteinuria is an unfavorable clinical condition highly associated with a risk of renal and cardiovascular disease in chronic kidney disease (CKD). However, whether all proteinuria forms are linked to renal im...

    Authors: Chun Gan, Xindi Zhou, Dan Chen, Huan Chi, Jiawen Qiu, Hui You, Yaxi Chen, Mo Wang, Haiping Yang, Wei Jiang and Qiu Li
    Citation: Journal of Translational Medicine 2022 20:480
  21. Explanted livers from patients with inherited metabolic liver diseases possess the potential to be a cell source of good-quality hepatocytes for hepatocyte transplantation (HT). This study evaluated the therap...

    Authors: Guang-Peng Zhou, Shi-Peng Li, Yi-Zhou Jiang, Jie Sun, Yu-Le Tan, Zhi-Gui Zeng, Lin Wei, Wei Qu, Li-Ying Sun and Zhi-Jun Zhu
    Citation: Journal of Translational Medicine 2022 20:479
  22. The combined association of triglyceride-glucose (TyG) index and different systolic blood pressure (SBP) levels with all-cause and cardiovascular mortality among the general population remains unclear.

    Authors: Yu Yu, Min Gu, Hao Huang, Sijing Cheng, Yu Deng, Chi Cai, Xuhua Chen, Hongxia Niu, Xiaohui Ning and Wei Hua
    Citation: Journal of Translational Medicine 2022 20:478
  23. Nutritional assessment and quality of life (QOL) have become important indices for therapeutic efficacy in patients with malignancies. We aim to develop and validate an easy-to-use questionnaire with prognosti...

    Authors: Bingdong Zhang, Yuerui Li and Yongbing Chen
    Citation: Journal of Translational Medicine 2022 20:477
  24. RNA methylation modifications, especially m6A mRNA modification, are known to be extensively involved in tumor development. However, the relationship between N3-methylcytidine (m3C) related genes and tumorigen...

    Authors: Shuai Wang, Huiting Li, Jiheng Liu, Qianqian Zhang, Wei Xu, Juanjuan Xiang, Li Fang, Ping Xu and Zheng Li
    Citation: Journal of Translational Medicine 2022 20:476
  25. Although anxiety disorders are one of the most prevalent mental disorders, their underlying biological mechanisms have not yet been fully elucidated. In recent years, genetically determined metabolites (GDMs) ...

    Authors: Gui Xiao, Qingnan He, Li Liu, Tingting Zhang, Mengjia Zhou, Xingxing Li, Yijun Chen, Yanyi Chen and Chunxiang Qin
    Citation: Journal of Translational Medicine 2022 20:475
  26. Ferroptosis is a new form of programmed cell death, which achieved great breakthroughs in cell biology during past decade. However, the regulation of ferroptosis is yet to be identified thoroughly. The latest ...

    Authors: Guixing Kuang, Weidong Wang, Dan Xiong and Chong Zeng
    Citation: Journal of Translational Medicine 2022 20:474
  27. As a key process in transcriptional regulatory mechanisms, alternative splicing (AS) plays a crucial role in maintaining the diversity of RNA and protein expression, and mediates the immune response in infecti...

    Authors: Yaxin Chen, Gang Wang, Jingyi Li, Lei Xia, Lin Zhu, Wenxing Li, Qiang Luo, Yinlu Liao, Yao Lin, Liyun Bi, Hubin Chen, Jiemei Chu, Yueqi Li, Jinming Su, Li Ye, Jun-jun Jiang…
    Citation: Journal of Translational Medicine 2022 20:473
  28. People living with HIV/AIDS (PLWHA) show a reduced incidence for three cancer types, namely breast, prostate and colon cancers. In the present study, we assessed whether a molecular mimicry between HIV epitope...

    Authors: Carmen Manolio, Concetta Ragone, Beatrice Cavalluzzo, Angela Mauriello, Maria Lina Tornesello, Franco M. Buonaguro, Angelo Salomone Megna, Giovanna D’Alessio, Roberta Penta, Maria Tagliamonte and Luigi Buonaguro
    Citation: Journal of Translational Medicine 2022 20:472
  29. Tumor-infiltrating lymphocytes (TILs) have become a promising biomarker for assessing tumor immune microenvironment and predicting immunotherapy response. However, the assessment of TILs relies on invasive pat...

    Authors: Guan-Hua Su, Yi Xiao, Lin Jiang, Ren-Cheng Zheng, He Wang, Yan Chen, Ya-Jia Gu, Chao You and Zhi-Ming Shao
    Citation: Journal of Translational Medicine 2022 20:471
  30. Trimethylamine oxide (TMAO) is a biomarker in cardiovascular and renal diseases. TMAO originates from the oxidation of trimethylamine (TMA), a product of gut microbiota and manufacturing industries-derived pol...

    Authors: Klaudia M. Maksymiuk, Mateusz Szudzik, Marta Gawryś-Kopczyńska, Maksymilian Onyszkiewicz, Emilia Samborowska, Izabella Mogilnicka and Marcin Ufnal
    Citation: Journal of Translational Medicine 2022 20:470
  31. Melanoma is the deadliest form of skin cancer and metastatic disease is associated with a significant survival rate drop. There is an urgent need for consistent tumor biomarkers to scale precision medicine and...

    Authors: Claudia Sabato, Teresa Maria Rosaria Noviello, Alessia Covre, Sandra Coral, Francesca Pia Caruso, Zein Mersini Besharat, Elena Splendiani, Laura Masuelli, Cecilia Battistelli, Alessandra Vacca, Giuseppina Catanzaro, Agnese Po, Andrea Anichini, Michele Maio, Michele Ceccarelli, Anna Maria Di Giacomo…
    Citation: Journal of Translational Medicine 2022 20:469
  32. Immunotherapy has dramatically improved cancer treatment by inhibiting or activating specific cell receptors, thus unleashing the host anti-tumor response. However, the engagement of the three main immune chec...

    Authors: Claudia Giampietri, Francesca Scatozza, Elena Crecca, Virginia Vigiano Benedetti, Pier Giorgio Natali and Antonio Facchiano
    Citation: Journal of Translational Medicine 2022 20:467
  33. Liver carcinoma generally presents as an immunosuppressive microenvironment that promotes tumor evasion. The intercellular crosstalk of immune cells significantly influences the construction of an immunosuppre...

    Authors: Zhuomao Mo, Daiyuan Liu, Yihan Chen, Jin Luo, Wenjing Li, Jiahui Liu, Ling Yu, Bijun Huang and Shijun Zhang
    Citation: Journal of Translational Medicine 2022 20:466
  34. MicroRNA (miRNA) is accepted as a critical regulator of cell differentiation. However, whether microRNA-223 (miR-223) could affect the osteogenic differentiation of periodontal ligament (PDL)-derived cells is ...

    Authors: Zheng Zhang, Minghui Wang, Youli Zheng, Yanmei Dai, Jiashu Chou, Xiaowei Bian, Pengcheng Wang, Changyi Li and Jing Shen
    Citation: Journal of Translational Medicine 2022 20:465
  35. Soft tissue sarcomas (STS) are heterogeneous and pro-metastatic tumors. Identification of accurate prognostic factors and novel therapeutic targets are crucial. CSPG4 is a cell surface proteoglycan with oncoge...

    Authors: Laurys Boudin, A de Nonneville, Pascal Finetti, Léna Mescam, A Le Cesne, Antoine Italiano, Jean-Yves Blay, Daniel Birnbaum, Emilie Mamessier and François Bertucci
    Citation: Journal of Translational Medicine 2022 20:464
  36. Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer. The pain caused by TAE is a stark complication, which remains to be prevented by biomedical eng...

    Authors: Chuan Tian, Zijian Wang, Lei Huang, Yimin Liu, Kunpeng Wu, Zhaonan Li, Bin Han, Dechao Jiao, Xinwei Han and Yanan Zhao
    Citation: Journal of Translational Medicine 2022 20:463
  37. Single-cell transcription data provided unprecedented molecular information, enabling us to directly encode the ecosystem of colorectal cancer (CRC). Characterization of the diversity of epithelial cells and h...

    Authors: Rongfang Shen, Ping Li, Botao Zhang, Lin Feng and Shujun Cheng
    Citation: Journal of Translational Medicine 2022 20:462
  38. Abdominal aortic aneurysm (AAA) represents the serious vascular degenerative disorder, which causes high incidence and mortality. Alpha-ketoglutarate (AKG), a crucial metabolite in the tricarboxylic acid (TCA)...

    Authors: Junjun Liu, Mingyuan Liu, Jiaxuan Feng, Hongqiao Zhu, Jianlie Wu, Heng Zhang, Shun Xiao, Zaiping Jing, Jian Zhou, Haitao Niu and Mingjin Guo
    Citation: Journal of Translational Medicine 2022 20:461
  39. Probiotics have been defined as “living microorganisms that create health benefits in the host when taken in sufficient amounts. Recent developments in the understanding of the relationship between the microbi...

    Authors: Duygu Ağagündüz, Feray Gençer Bingöl, Elif Çelik, Özge Cemali, Çiler Özenir, Fatih Özoğul and Raffaele Capasso
    Citation: Journal of Translational Medicine 2022 20:460
  40. Integrative analysis approaches of metagenomics and metabolomics have been widely developed to understand the association between disease and the gut microbiome. However, the different profiling patterns of di...

    Authors: Lanlan Zhao, Cheng Wang, Shanxin Peng, Xiaosong Zhu, Ziyi Zhang, Yanyan Zhao, Jinling Zhang, Guoping Zhao, Tao Zhang, Xueyuan Heng and Lei Zhang
    Citation: Journal of Translational Medicine 2022 20:459
  41. The low number of patients suffering from any given rare diseases poses a difficult problem for medical research: With the exception of some specialized biobanks and disease registries, potential study partici...

    Authors: Tobias Kussel, Torben Brenner, Galina Tremper, Josef Schepers, Martin Lablans and Kay Hamacher
    Citation: Journal of Translational Medicine 2022 20:458
  42. Epithelial-to-mesenchymal transition (EMT) is a critical event contributing to more aggressive phenotypes in cancer cells. EMT is frequently activated in radiation-targeted cells during the course of radiother...

    Authors: Xiao-Ya Sun, Hao-Zheng Li, Da-Fei Xie, Shan-Shan Gao, Xin Huang, Hua Guan, Chen-Jun Bai and Ping-Kun Zhou
    Citation: Journal of Translational Medicine 2022 20:456
  43. Pancreatic adenocarcinoma (PAAD) is one of the most common malignant tumors of the digestive tract. Pyroptosis is a newly discovered programmed cell death that highly correlated with the prognosis of tumors. H...

    Authors: Cheng Yan, Yandie Niu, Feng Li, Wei Zhao and Liukai Ma
    Citation: Journal of Translational Medicine 2022 20:455
  44. Liver metastases are a major contributor to the poor immunotherapy response in colorectal cancer patients. However, the distinctions in the immune microenvironment between primary tumors and liver metastases a...

    Authors: Yangsong He, Yanan Han, A-hui Fan, Danxiu Li, Boda Wang, Kun Ji, Xin Wang, Xiaodi Zhao and Yuanyuan Lu
    Citation: Journal of Translational Medicine 2022 20:454
  45. We proposed an artificial intelligence-based immune index, Deep-immune score, quantifying the infiltration of immune cells interacting with the tumor stroma in hematoxylin and eosin-stained whole-slide images ...

    Authors: Jing Yang, Huifen Ye, Xinjuan Fan, Yajun Li, Xiaomei Wu, Minning Zhao, Qingru Hu, Yunrui Ye, Lin Wu, Zhenhui Li, Xueli Zhang, Changhong Liang, Yingyi Wang, Yao Xu, Qian Li, Su Yao…
    Citation: Journal of Translational Medicine 2022 20:451
  46. Adipose tissue-derived adipokines are involved in various crosstalk between adipose tissue and other organs. Omentin1, a novel adipokine, exerts vital roles in the maintenance of body metabolism, insulin resis...

    Authors: Jingui Hu, Tao Liu, Fei Fu, Zekun Cui, Qiong Lai, Yuanyuan Zhang, Boyang Yu, Fuming Liu, Junping Kou and Fang Li
    Citation: Journal of Translational Medicine 2022 20:447

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