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  1. Protocol

    A phase I/II trial of fixed-dose stereotactic body radiotherapy with sequential or concurrent pembrolizumab in metastatic urothelial carcinoma: evaluation of safety and clinical and immunologic response

    Current first-line standard of therapy for metastatic urothelial carcinoma is platinum-based combination chemotherapy. Pembrolizumab in phase III has demonstrated a promising overall response rate of 21.1% in ...

    Nora Sundahl, Katrien De Wolf, Sylvie Rottey, Karel Decaestecker, Daan De Maeseneer, Annabel Meireson, Els Goetghebeur, Valérie Fonteyne, Sofie Verbeke, Pieter De Visschere, Dries Reynders, Mireille Van Gele, Lieve Brochez and Piet Ost

    Journal of Translational Medicine 2017 15:150

    Published on: 29 June 2017

  2. Research

    Identification of clear cell renal cell carcinoma and oncocytoma using a three-gene promoter methylation panel

    Promoter methylation has emerged as a promising class of epigenetic biomarkers for diagnosis and prognosis of renal cell tumors (RCTs). Although differential gene promoter methylation patterns have been report...

    Ana Sílvia Pires-Luís, Pedro Costa-Pinheiro, Maria João Ferreira, Luís Antunes, Francisco Lobo, Jorge Oliveira, Rui Henrique and Carmen Jerónimo

    Journal of Translational Medicine 2017 15:149

    Published on: 29 June 2017

  4. Research

    Transplantation of human fetal pancreatic progenitor cells ameliorates renal injury in streptozotocin-induced diabetic nephropathy

    Diabetic nephropathy (DN) is a severe complication of diabetes mellitus (DM). Pancreas or islet transplantation has been reported to prevent the development of DN lesions and ameliorate or reverse existing glo...

    Yongwei Jiang, Wenjian Zhang, Shiqing Xu, Hua Lin, Weiguo Sui, Honglin Liu, Liang Peng, Qing Fang, Li Chen and Jinning Lou

    Journal of Translational Medicine 2017 15:147

    Published on: 27 June 2017

  5. Research

    Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study

    Serous chorioretinopathy has been associated with MEK inhibitors, including cobimetinib. We describe the clinical features of serous retinopathy observed with cobimetinib in patients with BRAF ...

    Luis de la Cruz-Merino, Lorenza Di Guardo, Jean-Jacques Grob, Alfredo Venosa, James Larkin, Grant A. McArthur, Antoni Ribas, Paolo A. Ascierto, Jeffrey T. R. Evans, Antonio Gomez-Escobar, Giulio Barteselli, Susan Eng, Jessie J. Hsu, Anne Uyei and Brigitte Dréno

    Journal of Translational Medicine 2017 15:146

    Published on: 24 June 2017

  6. Methodology

    Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis

    Metastatic uveal melanoma is a highly fatal disease; most patients die from their hepatic metastasis within 1 year. A major drawback in the development of new treatments for metastatic uveal melanoma is the di...

    Ken Kageyama, Masahiro Ohara, Kengo Saito, Shinji Ozaki, Mizue Terai, Michael J. Mastrangelo, Paolo Fortina, Andrew E. Aplin and Takami Sato

    Journal of Translational Medicine 2017 15:145

    Published on: 23 June 2017

  7. Research

    Imaging of αvβ3 integrin expression in experimental myocardial ischemia with [68Ga]NODAGA-RGD positron emission tomography

    Radiolabeled RGD peptides detect αvβ3 integrin expression associated with angiogenesis and extracellular matrix remodeling after myocardial infarction. We studied whether cardiac positron emission tomography (PET...

    Maria Grönman, Miikka Tarkia, Tuomas Kiviniemi, Paavo Halonen, Antti Kuivanen, Timo Savunen, Tuula Tolvanen, Jarmo Teuho, Meeri Käkelä, Olli Metsälä, Mikko Pietilä, Pekka Saukko, Seppo Ylä-Herttuala, Juhani Knuuti, Anne Roivainen and Antti Saraste

    Journal of Translational Medicine 2017 15:144

    Published on: 19 June 2017

  8. Research

    Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis

    Stromal vascular fraction (SVF) can easily be obtained from a mini-lipoaspirate procedure of fat tissue and platelet rich plasma (PRP) can be obtained from peripheral blood. We evaluated the safety and prelimi...

    Himanshu Bansal, Kristin Comella, Jerry Leon, Poonam Verma, Diwaker Agrawal, Prasad Koka and Thomas Ichim

    Journal of Translational Medicine 2017 15:141

    Published on: 19 June 2017

  10. Research

    Stromal vascular fraction cells for the treatment of critical limb ischemia: a pilot study

    Cell-based therapy is being explored as an alternative treatment option for critical limb ischemia (CLI), a disease associated with high amputation and mortality rates and poor quality of life. However, therap...

    Adas Darinskas, Mindaugas Paskevicius, Gintaras Apanavicius, Gintaris Vilkevicius, Liutauras Labanauskas, Thomas E. Ichim and Rytis Rimdeika

    Journal of Translational Medicine 2017 15:143

    Published on: 19 June 2017

  11. Review

    Molecular imaging biomarkers for cell-based immunotherapies

    While many decades of scientific research studies have gone into harnessing the power of the immune system to fight cancer, only recently have cancer immunotherapeutic approaches begun to show robust clinical ...

    Mohammad Haris, Puneet Bagga, Hari Hariharan, Bevin McGettigan-Croce, Laura A. Johnson and Ravinder Reddy

    Journal of Translational Medicine 2017 15:140

    Published on: 19 June 2017

  12. Research

    Synaptonemal complex protein 3 is associated with lymphangiogenesis in non-small cell lung cancer patients with lymph node metastasis

    The interaction of vascular endothelial growth factor-C (VEGF-C)/VEGF-D/VEGF receptor-3 is considered to be a major driver of lymphangiogenesis, however the mechanism of this process remains unclear. We aimed ...

    Haruhisa Kitano, Joon-Yong Chung, Kyung Hee Noh, Young-Ho Lee, Tae Woo Kim, Seok Hyung Lee, Soo-Heang Eo, Hyung Jun Cho, Chel Hun Choi, Shuhei Inoue, Jun Hanaoka, Junya Fukuoka and Stephen M. Hewitt

    Journal of Translational Medicine 2017 15:138

    Published on: 17 June 2017

  13. Review

    Precision medicine in breast cancer: reality or utopia?

    Many cancers, including breast cancer, have demonstrated prognosis and support advantages thanks to the discovery of targeted therapies. The advent of these new approaches marked the rise of precision medicine...

    Ali Bettaieb, Catherine Paul, Stéphanie Plenchette, Jingxuan Shan, Lotfi Chouchane and François Ghiringhelli

    Journal of Translational Medicine 2017 15:139

    Published on: 17 June 2017

  14. Research

    Xenon in the treatment of panic disorder: an open label study

    Current treatments of panic disorder (PD) are limited by adverse effects, poor efficacy, and need for chronic administration. The established safety profile of subanesthetic concentrations of xenon gas, which ...

    Alexander Dobrovolsky, Thomas E. Ichim, Daqing Ma, Santosh Kesari and Vladimir Bogin

    Journal of Translational Medicine 2017 15:137

    Published on: 13 June 2017

  15. Erratum

    Erratum to: Similar cardiometabolic effects of high- and moderate-intensity training among apparently healthy inactive adults: a randomized clinical trial

    Robinson Ramírez-Vélez, Alejandra Tordecilla-Sanders, Luis Andrés Téllez-T, Diana Camelo-Prieto, Paula Andrea Hernández-Quiñonez, Jorge Enrique Correa-Bautista, Antonio Garcia-Hermoso, Rodrigo Ramirez-Campillo and Mikel Izquierdo

    Journal of Translational Medicine 2017 15:136

    Published on: 13 June 2017

    The original article was published in Journal of Translational Medicine 2017 15:118

  16. Research

    Can psychobiotics intake modulate psychological profile and body composition of women affected by normal weight obese syndrome and obesity? A double blind randomized clinical trial

    Evidence of probiotics effects on gut function, brain activity and emotional behaviour were provided. Probiotics can have dramatic effects on behaviour through the microbiome–gut–brain axis, through vagus nerv...

    Antonino De Lorenzo, Micaela Costacurta, Giuseppe Merra, Paola Gualtieri, Giorgia Cioccoloni, Massimiliano Marchetti, Dimitrios Varvaras, Raffaella Docimo and Laura Di Renzo

    Journal of Translational Medicine 2017 15:135

    Published on: 10 June 2017

  17. Research

    Development of an objective gene expression panel as an alternative to self-reported symptom scores in human influenza challenge trials

    Influenza challenge trials are important for vaccine efficacy testing. Currently, disease severity is determined by self-reported scores to a list of symptoms which can be highly subjective. A more objective m...

    Julius Muller, Eneida Parizotto, Richard Antrobus, James Francis, Campbell Bunce, Amanda Stranks, Marshall Nichols, Micah McClain, Adrian V. S. Hill, Adaikalavan Ramasamy and Sarah C. Gilbert

    Journal of Translational Medicine 2017 15:134

    Published on: 8 June 2017

  18. Research

    Exercise in claudicants increase or decrease walking ability and the response relates to mitochondrial function

    Exercise of patients with intermittent claudication improves walking performance. Exercise does not usually increase blood flow, but seems to increase muscle mitochondrial enzyme activities. Although exercise ...

    Michel van Schaardenburgh, Martin Wohlwend, Øivind Rognmo and Erney J. R. Mattsson

    Journal of Translational Medicine 2017 15:130

    Published on: 7 June 2017

  19. Research

    Distinct expression profile of HCMV encoded miRNAs in plasma from oral lichen planus patients

    Oral lichen planus (OLP) is a T cell-mediated autoimmune disease. The aetiology and molecular mechanisms of OLP remain unclear. Human cytomegalovirus (HCMV) infection is a causal factor in the development of v...

    Meng Ding, Xiang Wang, Cheng Wang, Xiaoshuang Liu, Ke Zen, Wenmei Wang, Chen-Yu Zhang and Chunni Zhang

    Journal of Translational Medicine 2017 15:133

    Published on: 7 June 2017

  20. Review

    State of play and clinical prospects of antibody gene transfer

    Recombinant monoclonal antibodies (mAbs) are one of today’s most successful therapeutic classes in inflammatory diseases and oncology. A wider accessibility and implementation, however, is hampered by the high...

    Kevin Hollevoet and Paul J. Declerck

    Journal of Translational Medicine 2017 15:131

    Published on: 7 June 2017

  21. Review

    Examining clinical similarities between myalgic encephalomyelitis/chronic fatigue syndrome and d-lactic acidosis: a systematic review

    The pursuit for clarity in diagnostic and treatment pathways for the complex, chronic condition of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) continues. This systematic review raises a novel q...

    Amy Wallis, Michelle Ball, Sandra McKechnie, Henry Butt, Donald P. Lewis and Dorothy Bruck

    Journal of Translational Medicine 2017 15:129

    Published on: 7 June 2017

  22. Research

    Betaine promotes cell differentiation of human osteoblasts in primary culture

    Betaine (BET), a component of many foods, is an essential osmolyte and a source of methyl groups; it also shows an antioxidant activity. Moreover, BET stimulates muscle differentiation via insulin like growth ...

    Isabella Villa, Pamela Senesi, Anna Montesano, Anita Ferraretto, Fernanda Vacante, Alice Spinello, Michela Bottani, Simona Bolamperti, Alessandro Rubinacci, Livio Luzi and Ileana Terruzzi

    Journal of Translational Medicine 2017 15:132

    Published on: 7 June 2017

  23. Research

    Osteoclast profile of medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis

    The medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy [MRONJ (BP)] is characterized by non-healing exposed bone in the maxillofacial region. The pathogenesis of MRONJ (BP) is not ...

    Christian Gross, Manuel Weber, Kay Creutzburg, Patrick Möbius, Raimund Preidl, Kerstin Amann and Falk Wehrhan

    Journal of Translational Medicine 2017 15:128

    Published on: 6 June 2017

  24. Research

    Sphingosine kinase 1 expression enhances colon tumor growth

    Accumulating evidence suggests that sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate pathway plays a pivotal role in colon carcinogenesis.

    Hideki Furuya, Yoshiko Shimizu, Paulette M. Tamashiro, Kayoko Iino, Jacek Bielawski, Owen T. M. Chan, Ian Pagano and Toshihiko Kawamori

    Journal of Translational Medicine 2017 15:120

    Published on: 6 June 2017

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