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  1. Fibrosis, a process caused by excessive deposition of extracellular matrix (ECM), is a common cause and outcome of organ failure and even death. Researchers have made many efforts to understand the mechanism o...

    Authors: Yangdan Liu, Dongsheng Wen, Chiakang Ho, Li Yu, Danning Zheng, Steven O’Reilly, Ya Gao, Qingfeng Li and Yifan Zhang
    Citation: Journal of Translational Medicine 2023 21:164
  2. Inherited retinal degeneration is a leading cause of incurable vision loss in the developed world. While autologous iPSC mediated photoreceptor cell replacement is theoretically possible, the lack of commercia...

    Authors: Laura R. Bohrer, Nicholas E. Stone, Nathaniel K. Mullin, Andrew P. Voigt, Kristin R. Anfinson, Jessica L. Fick, Viviane Luangphakdy, Bradley Hittle, Kimerly Powell, George F. Muschler, Robert F. Mullins, Edwin M. Stone and Budd A. Tucker
    Citation: Journal of Translational Medicine 2023 21:161
  3. Recent studies have shown the implication of the ROBO-SLIT pathway in heart development. Within this study, we aimed to further assess the implication of the ROBO and SLIT genes mainly in bicuspid aortic valve (B...

    Authors: Hager Jaouadi, Chris Jopling, Fanny Bajolle, Alexis Théron, Adèle Faucherre, Hilla Gerard, Sarab Al Dybiat, Caroline Ovaert, Damien Bonnet, Jean-François Avierinos and Stéphane Zaffran
    Citation: Journal of Translational Medicine 2023 21:160
  4. Cytoplasmic activation/proliferation-associated protein-1 (Caprin-1) is implicated in cancer cell proliferation and tumorigenesis; however, its role in the development of esophageal carcinoma (ESCA) has not be...

    Authors: Yan Gao, Lingling Yuan, Changbin Ke, Zhijun Pei, Xiaobo Liu, Ruimin Wu, Xueyan Kui and Yanmin Zhang
    Citation: Journal of Translational Medicine 2023 21:159
  5. Chimeric antigen receptor (CAR)-T cell therapies for the treatment of hematological malignancies experienced tremendous progress in the last decade. However, essential limitations need to be addressed to furt...

    Authors: Zhifen Yang, Violena Pietrobon, Maggie Bobbin, Ofir Stefanson, Jin Yang, Angshumala Goswami, Bennett Alphson, Hana Choi, Khristina Magallanes, Qi Cai, David Barrett, Bing Wang, Lei S. Qi and Francesco M. Marincola
    Citation: Journal of Translational Medicine 2023 21:158
  6. The United Nations recently made a call to address the challenges of an estimated 300 million persons worldwide living with a rare disease through the collection, analysis, and dissemination of disaggregated d...

    Authors: William Z. Kariampuzha, Gioconda Alyea, Sue Qu, Jaleal Sanjak, Ewy Mathé, Eric Sid, Haley Chatelaine, Arjun Yadaw, Yanji Xu and Qian Zhu
    Citation: Journal of Translational Medicine 2023 21:157
  7. Although the relationship between type 2 diabetes (T2D) and the increased risk of colorectal carcinogenesis is widely defined in clinical studies, the therapeutic methods and molecular mechanism of T2D-induced...

    Authors: Huiying Li, Chaonan Li, Boyang Zhang and Hongpeng Jiang
    Citation: Journal of Translational Medicine 2023 21:156
  8. Breast cancer (BC) is the second most common cancer and cause of death in women. In recent years many studies investigated the association of long non-coding RNAs (lncRNAs), as novel genetic factors, on BC ris...

    Authors: Morteza Gholami, Zeynab Nickhah Klashami, Pirooz Ebrahimi, Amir Ali Mahboobipour, Amir Salehi Farid, Aida Vahidi, Marziyeh Zoughi, Mojgan Asadi and Mahsa M. Amoli
    Citation: Journal of Translational Medicine 2023 21:155
  9. The relationship between muscle and prognosis, especially that between muscle distribution across different body parts, and the related prognosis is not well established.

    Authors: Chen-An Liu, Tong Liu, Yi-Zhong Ge, Meng-Meng Song, Guo-Tian Ruan, Shi-Qi Lin, Hai-Lun Xie, Jin-Yu Shi, Xin Zheng, Yue Chen, Liuyi Shen, Li Deng and Han-Ping Shi
    Citation: Journal of Translational Medicine 2023 21:154
  10. The interaction between the tumor-microenvironment (TME) and the cancer cells has emerged as a key player in colorectal cancer (CRC) metastasis. A small proportion of CRC cells which undergo epithelial-mesench...

    Authors: Jinsen Zheng, Rongzhang Dou, Xinyao Zhang, Bo Zhong, Chenggang Fang, Qian Xu, Ziyang Di, Sihao Huang, Zaihuan Lin, Jialin Song, Shuyi Wang and Bin Xiong
    Citation: Journal of Translational Medicine 2023 21:153
  11. At the end of December 2019, a novel strain of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) disease (COVID-19) has been identified in Wuhan, a central city in China, and then spread to every co...

    Authors: Mohammad Hadi Abbasian, Mohammadamin Mahmanzar, Karim Rahimian, Bahar Mahdavi, Samaneh Tokhanbigli, Bahman Moradi, Mahsa Mollapour Sisakht and Youping Deng
    Citation: Journal of Translational Medicine 2023 21:152
  12. Cancer-testis antigens (CTAs) are often expressed in tumor and testicular tissues but not in other normal tissues. To date, there has been no comprehensive study of the expression and clinical significance of ...

    Authors: Yu Miao, Yosuke Konno, Baojin Wang, Lin Zhu, Tianyue Zhai, Kei Ihira, Noriko Kobayashi, Hidemichi Watari, Xin Jin, Junming Yue, Peixin Dong and Mingyan Fang
    Citation: Journal of Translational Medicine 2023 21:151
  13. Alterations in the MET gene, including amplifications and exon 14 skipping mutations, have been identified as actionable oncogenic alterations. However, MET fusions are rarely detected in lung cancer, and thei...

    Authors: Dantong Sun, Weizheng Wu, Li Wang, Jialin Qu, Qiman Han, Huiyun Wang, Shanai Song, Ning Liu, Yongjie Wang and Helei Hou
    Citation: Journal of Translational Medicine 2023 21:150
  14. Periodontitis is the sixth most prevalent chronic disease globally and places significant burdens on societies and economies worldwide. Behavioral modification, risk factor control, coupled with cause-related ...

    Authors: Jianhan Ren, Melissa Rachel Fok, Yunfan Zhang, Bing Han and Yifan Lin
    Citation: Journal of Translational Medicine 2023 21:149
  15. Complex diseases often present as a diagnosis riddle, further complicated by the combination of multiple phenotypes and diseases as features of other diseases. With the aim of enhancing the determination of ke...

    Authors: Lynn M. Schriml, Richard Lichenstein, Katharine Bisordi, Cynthia Bearer, J. Allen Baron and Carol Greene
    Citation: Journal of Translational Medicine 2023 21:148
  16. Valtrate, a natural compound isolated from the root of Valeriana, exhibits antitumor activity in many cancers through different mechanisms. However, its efficacy for the treatment of glioblastoma (GBM), a tumor t...

    Authors: Xuemeng Liu, Yaotian Hu, Zhiyi Xue, Xun Zhang, Xiaofei Liu, Guowei Liu, Muzi Wen, Anjing Chen, Bin Huang, Xingang Li, Ning Yang and Jian Wang
    Citation: Journal of Translational Medicine 2023 21:147
  17. Kidney cancer undergoes a dramatic metabolic shift and has demonstrated responsiveness to immunotherapeutic intervention. However, metabolic classification and the associations between metabolic alterations an...

    Authors: Le Li, Zheng Chao, Un Waikeong, Jun Xiao, Yue Ge, Yanan Wang, Zezhong Xiong, Sheng Ma, Zhihua Wang, Zhiquan Hu and Xing Zeng
    Citation: Journal of Translational Medicine 2023 21:146
  18. The realization of the “microbiota–gut–brain” axis plays a critical role in neuropsychiatric disorders, particularly depression, is advancing rapidly. Matrine is a natural bioactive compound, which has been fo...

    Authors: Ming Zhang, Aoqiang Li, Qifang Yang, Jingyi Li, Lihua Zheng, Guannan Wang, Ying Sun, Yanxin Huang, Muqing Zhang, Zhenbo Song and Lei Liu
    Citation: Journal of Translational Medicine 2023 21:145
  19. Alpha-emitter radiopharmaceutical therapy (αRPT) has shown promising outcomes in metastatic disease. However, the short range of the alpha particles necessitates dosimetry on a near-cellular spatial scale. Cur...

    Authors: Remco Bastiaannet, Ioanna Liatsou, Robert F Hobbs and George Sgouros
    Citation: Journal of Translational Medicine 2023 21:144
  20. The left dorsolateral prefrontal cortex (DLPFC) is involved in early-phase manual dexterity skill acquisition when cognitive control processes, such as integration and complexity demands, are required. However...

    Authors: Akihiro Watanabe, Daisuke Sawamura, Hisato Nakazono, Yukina Tokikuni, Hiroshi Miura, Kazuhiro Sugawara, Kanako Fuyama, Harukazu Tohyama, Susumu Yoshida and Shinya Sakai
    Citation: Journal of Translational Medicine 2023 21:143
  21. Sepsis is a frequent complication in critically ill patients, is highly heterogeneous and is associated with high morbidity and mortality rates, especially in the elderly population. Utilizing RNA sequencing (...

    Authors: I-Chieh Chen, Hsin-Hua Chen, Yu-Han Jiang, Tzu-Hung Hsiao, Tai-Ming Ko and Wen-Cheng Chao
    Citation: Journal of Translational Medicine 2023 21:141
  22. Prognostic factors for initial response of advanced cutaneous squamous cell carcinoma to cemiplimab treatment are lacking. Il-6 has been found to affect immune cell populations which impact tumor development. ...

    Authors: Domenico Mallardo, Ester Simeone, Lucia Festino, Marilena Tuffanelli, Vito Vanella, Claudia Trojaniello, Maria Grazia Vitale, Margaret Ottaviano, Mariaelena Capone, Gabriele Madonna, Francesca Sparano, Eleonora Cioli, Luigi Scarpato, Marco Palla, Rossella Di Trolio, Paolo Meinardi…
    Citation: Journal of Translational Medicine 2023 21:140
  23. Exercise-related signaling Fndc5/irisin expresses in brain and acts as a crucial regulator of cognitive function, but its detailed roles in vascular dementia (VaD) are still unclear. Low intensity pulsed ultra...

    Authors: Degang Song, Xiaomin Chen, Na Zhou, Yi Yuan, Shuo Geng, Cong Zhang, Zhe Zhao, Xingran Wang, Xinran Bao, Xifa Lan and Xiangjian Zhang
    Citation: Journal of Translational Medicine 2023 21:139
  24. To explore the possibility of kidney organoids generated using patient derived human induced pluripotent stem cells (hiPSC) for modeling of Fabry disease nephropathy (FDN).

    Authors: Sheng Cui, Xianying Fang, Hanbi Lee, Yoo Jin Shin, Eun-Sil Koh, Sungjin Chung, Hoon Suk Park, Sun Woo Lim, Kang In Lee, Jae Young Lee, Chul Woo Yang and Byung Ha Chung
    Citation: Journal of Translational Medicine 2023 21:138
  25. Studies focusing on the relationships of adiposity and body shape indices with reproductive factors have reported conflicting results. This study aimed to investigate the influence of reproductive factors on a...

    Authors: Mina Amiri, Maryam Mousavi, Fereidoun Azizi and Fahimeh Ramezani Tehrani
    Citation: Journal of Translational Medicine 2023 21:137
  26. Mitochondria represent a major source of reactive oxygen species (ROS) in cells, and the direct increase in ROS content is the primary cause of oxidative stress, which plays an important role in tumor prolifer...

    Authors: Shiao Tong, Minqi Xia, Yang Xu, Qian Sun, Liguo Ye, Fanen Yuan, Yixuan Wang, Jiayang Cai, Zhang Ye and Daofeng Tian
    Citation: Journal of Translational Medicine 2023 21:136
  27. Cognitive function is an important ability of the brain, but cognitive dysfunction can easily develop once the brain is injured in various neuropathological conditions or diseases. Photobiomodulation therapy i...

    Authors: Wei-tong Pan, Pan-miao Liu, Daqing Ma and Jian-jun Yang
    Citation: Journal of Translational Medicine 2023 21:135
  28. Radiotherapy resistance is the main cause of treatment failure in nasopharyngeal carcinoma (NPC), which leads to poor prognosis. It is urgent to elucidate the molecular mechanisms underlying radiotherapy resis...

    Authors: Enni Chen, Jiajia Huang, Miao Chen, Jiawei Wu, Puyun Ouyang, Xiaonan Wang, Dingbo Shi, Zhiqiao Liu, Wancui Zhu, Haohui Sun, Shanshan Yang, Baoyu Zhang, Wuguo Deng, Huijuan Qiu and Fangyun Xie
    Citation: Journal of Translational Medicine 2023 21:134
  29. Neovascular age-related macular degeneration (nAMD) is a major cause of visual impairment and blindness. Anti-vascular endothelial growth factor (VEGF) agents, such as ranibizumab, bevacizumab, aflibercept, br...

    Authors: Levon M. Khachigian, Gerald Liew, Kelvin Y. C. Teo, Tien Y. Wong and Paul Mitchell
    Citation: Journal of Translational Medicine 2023 21:133
  30. Osteosarcoma is the most common malignant tumor in bone and its prognosis has reached a plateau in the past few decades. Recently, metabolic reprogramming has attracted increasing attention in the field of can...

    Authors: Gaohong Sheng, Yuan Gao, Qing Ding, Ruizhuo Zhang, Tianqi Wang, Shaoze Jing, Hongqi Zhao, Tian Ma, Hua Wu and Yong Yang
    Citation: Journal of Translational Medicine 2023 21:132
  31. 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) identifies carotid plaque inflammation and predicts stroke recurrence.

    Authors: Eduardo Garcia, Pol Camps-Renom, Núria Puig, Alejandro Fernández-Leon, Ana Aguilera-Simón, Aleyda Benitez-Amaro, Arnau Solé, David Vilades, José Luis Sanchez-Quesada, Joan Martí-Fàbregas, Elena Jiménez-Xarrié, Sonia Benitez and Vicenta Llorente-Cortés
    Citation: Journal of Translational Medicine 2023 21:131
  32. The incidence of bladder cancer (BCa) is approximately four times higher in men than in women. To develop effective BCa treatments, there is an urgent need to understand the differences in the BCa control mech...

    Authors: Jaekwon Seok, Hee Jeong Kwak, Yeonjoo Kwak, Moonjung Lee, Kyoung Sik Park, Aram Kim and Ssang-Goo Cho
    Citation: Journal of Translational Medicine 2023 21:129
  33. Obesity is accompanied by hormonal, inflammatory and endothelial alterations. These alterations induce a stimulation of several other mechanisms that contribute to the hypertensive state and to increase the ca...

    Authors: Luigi Barrea, Ludovica Verde, Pasquale Santangeli, Stefania Lucà, Annamaria Docimo, Silvia Savastano, Annamaria Colao and Giovanna Muscogiuri
    Citation: Journal of Translational Medicine 2023 21:128
  34. Osteoporosis is highly polygenic and heritable, with heritability ranging from 50 to 80%; most inherited susceptibility is associated with the cumulative effect of many common genetic variants. However, existi...

    Authors: Qing Wu and Jongyun Jung
    Citation: Journal of Translational Medicine 2023 21:127
  35. Gut mycobiota plays a crucial role in benign liver diseases; however, its correlation with hepatocellular carcinoma (HCC) remains elusive. This study aimed to elucidate fungal differences in patients with HCC-...

    Authors: Lilong Zhang, Chen Chen, Dongqi Chai, Chunlei Li, Zhendong Qiu, Tianrui Kuang, Li Liu, Wenhong Deng and Weixing Wang
    Citation: Journal of Translational Medicine 2023 21:126
  36. Histone deacetylases (HDAC) contribute to oncogenic program, pointing to their inhibitors as a potential strategy against cancers. We, thus, studied the mechanism of HDAC inhibitor ITF2357 in resistance of mut...

    Authors: Jian Cui, Fei Xu, Wei Bai, Tiantian Zhao, Junbo Hong and Wei Zuo
    Citation: Journal of Translational Medicine 2023 21:125
  37. Muscle-invasive urothelial bladder cancer (MIBC) is associated with limited response rates to systemic therapy, risk of recurrence and death. Tumor infiltrating immune cells have been associated with outcome a...

    Authors: Florestan J. Koll, Severine Banek, Luis Kluth, Jens Köllermann, Katrin Bankov, Felix K.-H. Chun, Peter J. Wild, Andreas Weigert and Henning Reis
    Citation: Journal of Translational Medicine 2023 21:124
  38. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has unpredictable manifestations of coronavirus disease (COVID-19) and variable clinical course with some patients being asymptom...

    Authors: Anna Lucia Tornesello, Chiara Botti, Alberto Micillo, Francesco Labonia, Sergio Arpino, Maria Antonietta Isgrò, Serena Meola, Luigi Russo, Ernesta Cavalcanti, Silvia Sale, Carmine Nicastro, Luigi Atripaldi, Noemy Starita, Andrea Cerasuolo, Ulf Reimer, Pavlo Holenya…
    Citation: Journal of Translational Medicine 2023 21:123
  39. Malfunction of astrocytes is implicated as one of the pathological factors of ALS. Thus, intrathecal injection of healthy astrocytes in ALS can potentially compensate for the diseased astrocytes. AstroRx® is a...

    Authors: Marc Gotkine, Yoseph Caraco, Yossef Lerner, Simcha Blotnick, Maor Wanounou, Shalom Guy Slutsky, Judith Chebath, Graciela Kuperstein, Elena Estrin, Tamir Ben-Hur, Arik Hasson, Kfir Molakandov, Tehila Sonnenfeld, Yafit Stark, Ariel Revel, Michel Revel…
    Citation: Journal of Translational Medicine 2023 21:122
  40. Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). Surgical resection of the liver metastases increases the incidence of long-term survival in patients with colorectal liv...

    Authors: Xiangdong Li, Ziyi Wang, Chenyu Jiao, Yu Zhang, Nan Xia, Wenjie Yu, Xuejiao Chen, Likalamu Pascalia Wikana, Yue Liu, Linfeng Sun, Minhao Chen, Yuhao Xiao, Yuhua Shi, Sheng Han and Liyong Pu
    Citation: Journal of Translational Medicine 2023 21:121
  41. Metastasis is the predominant cause of mortality in patients with breast cancer. Long noncoding RNAs (lncRNAs) have been shown to drive important phenotypes in tumors, including invasion and metastasis. Howeve...

    Authors: Rong Guo, Yonghui Su, Qi Zhang, Bingqiu Xiu, Sheng Huang, Weiru Chi, Liyi Zhang, Lun Li, Jianjing Hou, Jia Wang, Jiajian Chen, Yayun Chi, Jingyan Xue and Jiong Wu
    Citation: Journal of Translational Medicine 2023 21:120
  42. Ki-67 labeling index (LI) is an important indicator of tumor cell proliferation in glioma, which can only be obtained by postoperative biopsy at present. This study aimed to explore the correlation between Ki-...

    Authors: Ningfang Du, Weiquan Shu, Kefeng Li, Yao Deng, Xinxin Xu, Yao Ye, Feng Tang, Renling Mao, Guangwu Lin, Shihong Li and Xuhao Fang
    Citation: Journal of Translational Medicine 2023 21:119
  43. Cancer is a worldwide pandemic. The burden it imposes grows steadily on a global scale causing emotional, physical, and financial strains on individuals, families, and health care systems. Despite being the se...

    Authors: Siobhan Connal, James M. Cameron, Alexandra Sala, Paul M. Brennan, David S. Palmer, Joshua D. Palmer, Haley Perlow and Matthew J. Baker
    Citation: Journal of Translational Medicine 2023 21:118
  44. Gut dysbacteriosis has been reported as one of the etiologies for irritable bowel syndrome (IBS). However, the association between gut microbiota and IBS is still inconclusive.

    Authors: Han Chen, Rong Ou, Nana Tang, Wei Su, Ruoyun Yang, Xin Yu, Guoxin Zhang, Jianhua Jiao and Xiaoying Zhou
    Citation: Journal of Translational Medicine 2023 21:117
  45. Computed tomographies (CT) are useful for identifying muscle loss in non-small lung cancer (NSCLC) cachectic patients. However, we lack consensus on the best cutoff point for pectoralis muscle loss. We aimed t...

    Authors: Sarah Santiloni Cury, Diogo de Moraes, Jakeline Santos Oliveira, Paula Paccielli Freire, Patricia Pintor dos Reis, Miguel Luiz Batista Jr, Érica Nishida Hasimoto and Robson Francisco Carvalho
    Citation: Journal of Translational Medicine 2023 21:116
  46. Spermatogenesis associated serine rich 2 like (SPATS2L) was highly expressed in homoharringtonine (HHT) resistant acute myeloid leukemia (AML) cell lines. However, its role is little known in AML. The present ...

    Authors: Fenglin Li, Wenle Ye, Yiyi Yao, Wenwen Wei, Xiangjie Lin, Haihui Zhuang, Chenying Li, Xia Li, Qing Ling, Chao Hu, Xin Huang, Yu Qian, Shihui Mao, Jiansong Huang, Ying Lu and Jie Jin
    Citation: Journal of Translational Medicine 2023 21:115
  47. Multiple system atrophy (MSA) is a heterogenous, uniformly fatal neurodegenerative ɑ-synucleinopathy. Patients present with varying degrees of dysautonomia, parkinsonism, cerebellar dysfunction, and corticospi...

    Authors: Fan Shuen Tseng, Joel Qi Xuan Foo, Aaron Shengting Mai and Eng-King Tan
    Citation: Journal of Translational Medicine 2023 21:104

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