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  1. Content type: Meeting report

    Diagnosis of melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges in mel...

    Authors: Paolo A. Ascierto, Sanjiv S. Agarwala, Gerardo Botti, Alfredo Budillon, Michael A. Davies, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Silvia Formenti, Thomas F. Gajewski, Claus Garbe, Omid Hamid, Roger S. Lo, Jason J. Luke, Oliver Michielin, Giuseppe Palmieri…

    Citation: Journal of Translational Medicine 2019 17:234

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  2. Content type: Research

    The use of one-step nucleic acid amplification (OSNA) allows for lymph node (LN) metastasis to be detected rapidly and accurately. We conducted a prospective single-centre clinical trial to evaluate OSNA assay...

    Authors: María Escalante Pérez, María Teresa Hermida Romero, Begoña Otero Alén, Mónica Álvarez Martínez, Ricardo Fernández Prado, Mercedes de la Torre Bravos and Ángel Concha López

    Citation: Journal of Translational Medicine 2019 17:233

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  3. Content type: Research

    Bone metastases occur rarely in patients suffering from malignant melanoma, although their onset severely worsens both prognosis and quality of life. Extracellular vesicles (EVs) including exosomes (Exos) are ...

    Authors: Francesco Mannavola, Marco Tucci, Claudia Felici, Anna Passarelli, Stella D’Oronzo and Francesco Silvestris

    Citation: Journal of Translational Medicine 2019 17:230

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  4. Content type: Research

    Chemotherapy-induced left ventricular dysfunction represents a major clinical problem, which is often only recognised at an advanced stage, when supportive therapy is ineffective. Although an early heart failu...

    Authors: Mária Lódi, Dániel Priksz, Gábor Áron Fülöp, Beáta Bódi, Alexandra Gyöngyösi, Lilla Nagy, Árpád Kovács, Attila Béla Kertész, Judit Kocsis, István Édes, Zoltán Csanádi, István Czuriga, Zoltán Kisvárday, Béla Juhász, István Lekli, Péter Bai…

    Citation: Journal of Translational Medicine 2019 17:229

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  5. Content type: Research

    Chronic kidney disease (CKD) is a universal chronic disease in China. The balance of the gut microbiome is highly crucial for a healthy human body, especially for the immune system. However, the relationship b...

    Authors: Yang Li, Xinhuan Su, Lei Zhang, Yanwei Liu, Min Shi, Chenxiao Lv, Ying Gao, Dongmei Xu and Zunsong Wang

    Citation: Journal of Translational Medicine 2019 17:228

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  6. Content type: Research

    Diabetes is a chronic disease associated with many problems and high costs. In recent decades, a lot of research has been carried out in order to improve methods of treatment of diabetic patients. One of the c...

    Authors: Fouad Mehraban, Arefeh Seyedarabi, Shahin Ahmadian, Vahid Mirzaaghaei and Ali Akbar Moosavi-Movahedi

    Citation: Journal of Translational Medicine 2019 17:227

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  7. Content type: Research

    Adrenocorticotrophic hormone (ACTH)-treatment rat model has been utilized as a widely accepted model of treatment-resistant depression. Metabolomic signatures represent the pathophysiological phenotype of dise...

    Authors: Jing Song, Weini Ma, Xinyi Gu, Le Zhao, Jiaye Jiang, Ying Xu, Lei Zhang, Mingmei Zhou and Li Yang

    Citation: Journal of Translational Medicine 2019 17:224

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  8. Content type: Review

    Drug development is currently hampered by high attrition rates; many developed treatments fail during clinical testing. Part of the attrition may be due to low animal-to-human translational success rates; so-c...

    Authors: Cathalijn H. C. Leenaars, Carien Kouwenaar, Frans R. Stafleu, André Bleich, Merel Ritskes-Hoitinga, Rob B. M. De Vries and Franck L. B. Meijboom

    Citation: Journal of Translational Medicine 2019 17:223

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  9. Content type: Research

    Type 1 diabetes mellitus (T1DM) patients display increased risk of cardiovascular disease (CVD) and are characterized by a diminished regulatory T (Treg) cell content or function. Previous studies have shown a...

    Authors: Sergio Martínez-Hervás, Verónica Sánchez-García, Andrea Herrero-Cervera, Ángela Vinué, José Tomás Real, Juan F. Ascaso, Deborah Jane Burks and Herminia González-Navarro

    Citation: Journal of Translational Medicine 2019 17:222

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  10. Content type: Research

    The clinical significance of stem cell therapy in the treatment of dilated cardiomyopathy remains unclear. This systemic appraisal and meta-analysis aimed to assess the efficacy and safety of stem cell therapy...

    Authors: Shu-Ling Rong, Ze-Kun Wang, Xue-Dong Zhou, Xiao-Lin Wang, Zhi-Ming Yang and Bao Li

    Citation: Journal of Translational Medicine 2019 17:221

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  11. Content type: Research

    The influence of DNMT3A R882 mutations on adult acute myeloid leukemia (AML) prognosis is still controversial presently. The influence of R882 allele ratio on drug response and prognosis of AML is unknown yet. Be...

    Authors: Xiao-Qing Yuan, Peng Chen, Yin-Xiao Du, Ke-Wei Zhu, Dao-Yu Zhang, Han Yan, Han Liu, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Jing Yang, Wen-Jing Zeng and Xiao-Ping Chen

    Citation: Journal of Translational Medicine 2019 17:220

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  12. Content type: Research

    The pleiotropic cytokine, transforming growth factor (TGF)-β, and CD4+CD25+Foxp3+ regulatory T cells (Tregs) play a critical role in actively suppressing antitumor immune responses. Evidence shows that TGF-β prod...

    Authors: Magdalena J. Polanczyk, Edwin Walker, Daniel Haley, Bella S. Guerrouahen and Emmanuel T. Akporiaye

    Citation: Journal of Translational Medicine 2019 17:219

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  13. Content type: Research

    Immune infiltration may predict survival and have clinical significance in lung cancer. However, immune signatures derived from immune profiling based on bulk tumor transcriptomes have not been systematically ...

    Authors: Xiaodong Yang, Yu Shi, Ming Li, Tao Lu, Junjie Xi, Zongwu Lin, Wei Jiang, Weigang Guo, Cheng Zhan and Qun Wang

    Citation: Journal of Translational Medicine 2019 17:217

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  14. Content type: Research

    New treatment options for metastasised high-grade serous carcinoma (HGSC) are urgently needed. HGSC frequently metastasises to the omentum, inducing angiogenesis in the local omental microvasculature to facili...

    Authors: Md Zahidul I. Pranjol, Dmitry A. Zinovkin, Annelie R. T. Maskell, Laura J. Stephens, Sergey L. Achinovich, Dmitry M. Los’, Eldar A. Nadyrov, Michael Hannemann, Nicholas J. Gutowski and Jacqueline L. Whatmore

    Citation: Journal of Translational Medicine 2019 17:216

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  15. Content type: Research

    Tumor necrosis factor α (TNFα) is a multifunctional cytokine with a potent pro-inflammatory effect. It is a validated therapeutic target molecule for several disorders related to autoimmunity and inflammation....

    Authors: Madhu Sudhana Saddala and Hu Huang

    Citation: Journal of Translational Medicine 2019 17:215

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  16. Content type: Research

    To evaluate the imaging biomarkers of human epidermal growth factor receptor 2 (HER2) positive breast cancer in comparison to other molecular subtypes and to determine the feasibility of identifying hormone re...

    Authors: Chao You, Jianwei Li, Wenxiang Zhi, Yanqiong Chen, Wentao Yang, Yajia Gu and Weijun Peng

    Citation: Journal of Translational Medicine 2019 17:182

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  17. Content type: Research

    Acute ischemic stroke (AIS) due to large vessel occlusion (LVO) is a devastating cerebrovascular disorder, which could benefit from collateral circulation. Proteins associated with acute LVO pathogenesis and e...

    Authors: Chuan Qin, Xin-Ling Zhao, Xiao-Tong Ma, Luo-Qi Zhou, Long-jun Wu, Ke Shang, Wei Wang and Dai-Shi Tian

    Citation: Journal of Translational Medicine 2019 17:214

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  18. Content type: Review

    Chronic fatigue syndrome (CFS) is a heterogeneous disorder with uncertain pathogenesis. Without effective therapy, CFS is characterized by disabling fatigue, depression, memory loss, and somatic discomfort. Th...

    Authors: Tiansong Yang, Yan Yang, Delong Wang, Chaoran Li, Yuanyuan Qu, Jing Guo, Tianyu Shi, Wang Bo, Zhongren Sun and Tetsuya Asakawa

    Citation: Journal of Translational Medicine 2019 17:213

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  19. Content type: Research

    Lynch syndrome (LS) is a highly penetrant inherited cancer predisposition syndrome, characterized by autosomal dominant inheritance and germline mutations in DNA mismatch repair genes. Despite several genetic ...

    Authors: Amira Jaballah-Gabteni, Haifa Tounsi, Maria Kabbage, Yosr Hamdi, Sahar Elouej, Ines Ben Ayed, Mouna Medhioub, Moufida Mahmoudi, Hamza Dallali, Hamza Yaiche, Nadia Ben Jemii, Afifa Maaloul, Najla Mezghani, Sonia Abdelhak, Lamine Hamzaoui, Mousaddak Azzouz…

    Citation: Journal of Translational Medicine 2019 17:212

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  20. Content type: Research

    Extracellular vesicles from bone marrow-derived multipotent mesenchymal stromal cells (BMSC-EVs) can play important roles in the repair of injured tissues. However, no reports have investigated the role and un...

    Authors: Zhengzhou Shi, Qi Wang and Dapeng Jiang

    Citation: Journal of Translational Medicine 2019 17:211

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  21. Content type: Research

    Glioma is the most common primary malignant brain tumor in adults with a poor prognosis. ARL3 is a member of the ARF family, and plays a key role in ciliary function and lipid-modified protein trafficking. ARL...

    Authors: Yulin Wang, Weijiang Zhao, Xin Liu, Gefei Guan and Minghua Zhuang

    Citation: Journal of Translational Medicine 2019 17:210

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  22. Content type: Research

    Colorectal cancer (CRC) is the third leading cause of cancer-related mortality worldwide. Current systematic methods for diagnosing have inherent limitations so development of a minimally-invasive diagnosis, b...

    Authors: Berta Roman-Canal, Jordi Tarragona, Cristian Pablo Moiola, Sònia Gatius, Sarah Bonnin, Maria Ruiz-Miró, José Enrique Sierra, Maria Rufas, Esperanza González, José M. Porcel, Antonio Gil-Moreno, Juan M. Falcón-Pérez, Julia Ponomarenko, Xavier Matias-Guiu and Eva Colas

    Citation: Journal of Translational Medicine 2019 17:208

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  23. Content type: Research

    Head and neck squamous cell carcinoma (HNSCC) originates from squamous epithelium of the upper aerodigestive tract and is the most common malignancy in the head and neck region. Among HNSCCs, oropharynx squamo...

    Authors: Yui Hirata-Nozaki, Takayuki Ohkuri, Kenzo Ohara, Takumi Kumai, Marino Nagata, Shohei Harabuchi, Akemi Kosaka, Toshihiro Nagato, Kei Ishibashi, Kensuke Oikawa, Naoko Aoki, Mizuho Ohara, Yasuaki Harabuchi, Yuji Uno, Hidehiro Takei, Esteban Celis…

    Citation: Journal of Translational Medicine 2019 17:207

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  24. Content type: Research

    Given the benefits of physical activity for health and survival, clinicians are seeking opportunities for cancer patients to become more active independent of rehabilitation programs that are small, time-limit...

    Authors: Catherine M. Sabiston, Angela J. Fong, Erin K. O’Loughlin and Sarkis Meterissian

    Citation: Journal of Translational Medicine 2019 17:206

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  25. Content type: Research

    In our recent clinical trial, increased peripheral concentrations of pro-inflammatory molecular mediators were determined in complex regional pain syndrome (CRPS) patients. After 3 months adjunctive unilateral...

    Authors: Thomas M. Kinfe, Maria Asif, Krishnan V. Chakravarthy, Timothy R. Deer, Jeffery M. Kramer, Thomas L. Yearwood, Rene Hurlemann, Muhammad Sajid Hussain, Susanne Motameny, Prerana Wagle, Peter Nürnberg, Sascha Gravius, Thomas Randau, Nadine Gravius, Shafqat R. Chaudhry and Sajjad Muhammad

    Citation: Journal of Translational Medicine 2019 17:205

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  26. Content type: Research

    Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker of early diagnosis and prediction for acute kidney injury (AKI). However, the current program for NGAL detection is not extensively ap...

    Authors: Xiaoqian Hong, Huihui Yan, Fuan Xie, Kaiyu Wang, Qiang Wang, Huijuan Huang, Kunrong Yang, Suhong Huang, Tingting Zhao, Junkai Wang, Yunyun Chen, Kuancan Liu and Xiaopeng Lan

    Citation: Journal of Translational Medicine 2019 17:204

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  27. Content type: Research

    Due to the phenotypic and molecular diversity of hepatocellular carcinomas (HCC), it is still a challenge to determine patients’ prognosis. We aim to identify new prognostic markers for resected HCC patients.

    Authors: Gui-Qi Zhu, Yi Yang, Er-Bao Chen, Biao Wang, Kun Xiao, Shi-Ming Shi, Zheng-Jun Zhou, Shao-Lai Zhou, Zheng Wang, Ying-Hong Shi, Jia Fan, Jian Zhou, Tian-Shu Liu and Zhi Dai

    Citation: Journal of Translational Medicine 2019 17:203

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  28. Content type: Research

    Serum uric acid (SUA) had been associated with incident hypertension, but it is uncertain whether and to what extent the effect of SUA is mediated by other metabolic factors.

    Authors: Zhi Cao, Yangyang Cheng, Shu Li, Hongxi Yang, Li Sun, Ying Gao, Pei Yu, Weidong Li and Yaogang Wang

    Citation: Journal of Translational Medicine 2019 17:202

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  29. Content type: Research

    The human epidermal growth factor receptor (HER) family of transmembrane tyrosine kinases is overexpressed and correlates with poor prognosis and decreased survival in many cancers. The receptor family has bee...

    Authors: Sabrina A. Maisel, Derrick Broka, Benjamin Atwell, Thomas Bunch, Robert Kupp, Shiv K. Singh, Shwetal Mehta and Joyce Schroeder

    Citation: Journal of Translational Medicine 2019 17:201

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  30. Content type: Research

    “Nanomedicine” is the application of purposely designed nano-scale materials for improved therapeutic and diagnostic outcomes, which cannot be otherwise achieved using conventional delivery approaches. While “...

    Authors: Jie Feng, Chester E. Markwalter, Chang Tian, Madeleine Armstrong and Robert K. Prud’homme

    Citation: Journal of Translational Medicine 2019 17:200

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  31. Content type: Research

    Platelets not only contribute to hemostasis but also to the regulation of inflammatory reactions and cancer pathogenesis. We hypothesized that blood platelet count would be associated with systemic inflammatio...

    Authors: Juha P. Väyrynen, Sara A. Väyrynen, Päivi Sirniö, Ilkka Minkkinen, Kai Klintrup, Toni Karhu, Jyrki Mäkelä, Karl-Heinz Herzig, Tuomo J. Karttunen, Anne Tuomisto and Markus J. Mäkinen

    Citation: Journal of Translational Medicine 2019 17:199

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  32. Content type: Research

    Diffuse large B-cell lymphoma (DLBCL) is classified into germinal center-like (GCB) and non-germinal center-like (non-GCB) cell-of-origin groups, entities driven by different oncogenic pathways with different ...

    Authors: Yocanxóchitl Perfecto-Avalos, Alejandro Garcia-Gonzalez, Ana Hernandez-Reynoso, Gildardo Sánchez-Ante, Carlos Ortiz-Hidalgo, Sean-Patrick Scott, Rita Q. Fuentes-Aguilar, Ricardo Diaz-Dominguez, Grettel León-Martínez, Verónica Velasco-Vales, Mara A. Cárdenas-Escudero, José A. Hernández-Hernández, Arturo Santos, José R. Borbolla-Escoboza and Luis Villela

    Citation: Journal of Translational Medicine 2019 17:198

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  33. Content type: Research

    Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are intracellular sensors of pathogens and molecules from damaged cells to regulate the inflammatory response in the innate immune system. ...

    Authors: Luo-Yi Wang, Xiao-Jing Sun, Min Chen and Ming-Hui Zhao

    Citation: Journal of Translational Medicine 2019 17:197

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  34. Content type: Research

    Current syphilis tests cannot distinguish between active and past syphilis among patients with serofast rapid plasma reagin (RPR) titers. We investigated whether cytokine profiles might provide insight in the ...

    Authors: N. Kojima, J. C. Siebert, H. Maecker, Y. Rosenberg-Hasson, S. R. Leon, S. K. Vargas, K. A. Konda, C. F. Caceres and J. D. Klausner

    Citation: Journal of Translational Medicine 2019 17:196

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  35. Content type: Research

    Although methyl-tertiary butyl ether (MTBE) is the only clinical topical agent for gallstone dissolution, its use is limited by its side effects mostly arising from a relatively low boiling point (55 °C). In t...

    Authors: Ho Joong Choi, Suk Joon Cho, Ok-Hee Kim, Jin Sook Song, Ha-Eun Hong, Sang Chul Lee, Kee-Hwan Kim, Sang Kuon Lee, Young Kyoung You, Tae Ho Hong, Eun Young Kim, Jung Hyun Park, Gun Hyung Na, Dong Do You, Jae Hyun Han, Jae Woo Park…

    Citation: Journal of Translational Medicine 2019 17:195

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  36. Content type: Research

    One main challenge in ovarian cancer rests on the presence of a relapse and an important metastatic disease, despite extensive surgical debulking and chemotherapy. The difficulty in containing metastatic cance...

    Authors: Jessica Hoarau-Véchot, Cyril Touboul, Najeeb Halabi, Morgane Blot-Dupin, Raphael Lis, Charbel Abi Khalil, Shahin Rafii, Arash Rafii and Jennifer Pasquier

    Citation: Journal of Translational Medicine 2019 17:194

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  37. Content type: Research

    Lymph node status and liver metastasis (LIM) are important in determining the prognosis of early colon carcinoma. We attempted to develop and validate nomograms to predict lymph node metastasis (LNM) and LIM i...

    Authors: Yongcong Yan, Haohan Liu, Kai Mao, Mengyu Zhang, Qianlei Zhou, Wei Yu, Bingchao Shi, Jie Wang and Zhiyu Xiao

    Citation: Journal of Translational Medicine 2019 17:193

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  38. Content type: Research

    Gastric cancer (GC) remains a refractory cancer worldwide. Currently, exploring the differences of the immune status in GC patients with different subgroups might provide promising immunotherapeutic approaches...

    Authors: Xu Liu, Danhua Xu, Chen Huang, Yixian Guo, Shuchang Wang, Chunchao Zhu, Jia Xu, Zizhen Zhang, Yanying Shen, Wenyi Zhao and Gang Zhao

    Citation: Journal of Translational Medicine 2019 17:192

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  39. Content type: Research

    Elevated protein expressions of CD markers such as IL2RA/CD25, CXCR4/CD184, CD34 and CD56 are associated with adverse prognosis in acute myeloid leukemia (AML). However, the prognostic value of mRNA expression...

    Authors: Wen Du, Jing He, Wei Zhou, Simin Shu, Juan Li, Wei Liu, Yun Deng, Cong Lu, Shengyan Lin, Yaokun Ma, Yanli He, Jine Zheng, Jiang Zhu, Lijuan Bai, Xiaoqing Li, Junxia Yao…

    Citation: Journal of Translational Medicine 2019 17:191

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  40. Content type: Research

    Ovarian cancer (OC) is one of the leading causes for cancer-related deaths among women. MicroRNAs (miRs) have been proved to be vital to the development and progression of OC. Hence, the study aims to evaluate...

    Authors: Jun Dai, Rujia Wei, Peihai Zhang and Beihua Kong

    Citation: Journal of Translational Medicine 2019 17:190

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  41. Content type: Research

    Gastric cancer (GC) is a leading cause of cancer deaths, and an increased number of GC patients adopt to next-generation sequencing (NGS) to identify tumor genomic alterations for precision medicine.

    Authors: Hui Cai, Changqing Jing, Xusheng Chang, Dan Ding, Ting Han, Junchi Yang, Zhengmao Lu, Xuguang Hu, Zhaorui Liu, Jinshen Wang, Liang Shang, Shouxin Wu, Peng Meng, Ling Lin, Jiangman Zhao, Mingming Nie…

    Citation: Journal of Translational Medicine 2019 17:189

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  42. Content type: Research

    Tumors develop by progression through a series of stages. Every cell of the tumor microenvironment is constantly changing in the flow of the cancer progression. It has become clear in recent years that stroma ...

    Authors: F. Lessi, C. Scatena, P. Aretini, M. Menicagli, S. Franceschi, A. G. Naccarato and C. M. Mazzanti

    Citation: Journal of Translational Medicine 2019 17:187

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  43. Content type: Research

    Early diagnosis is critical to reduce the mortality caused by nasopharyngeal carcinoma (NPC). MicroRNAs (miRNAs) are dysregulated and play important roles in carcinogenesis. Therefore, this study aimed to iden...

    Authors: Wen Wen, Shi-Juan Mai, Huan-Xin Lin, Mei-Yin Zhang, Jia-Ling Huang, Xin Hua, Chao Lin, Zhi-Qing Long, Zi-Jian Lu, Xiao-Qing Sun, Sai-Lan Liu, Qi Yang, Qian Zhu, Hui-Yun Wang and Ling Guo

    Citation: Journal of Translational Medicine 2019 17:186

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  44. Content type: Research

    Orthostatic intolerance (OI) is a significant problem for those with chronic fatigue syndrome (CFS). We aimed to characterize orthostatic intolerance in CFS and to study the effects of exercise on OI.

    Authors: Richard Garner and James N. Baraniuk

    Citation: Journal of Translational Medicine 2019 17:185

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