Articles

Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is a serious public health issue affecting 9–15% of all pregnancies worldwide. Recently, it has been suggested that extracellular vesicles (EVs) play a role throughout gesta...

Authors: Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacós, Fátima Crispi, Gregory Duncombe, Martha Lappas…

Use of proteomics to identify mechanisms of hepatocellular carcinoma with the CYP2D6*10 polymorphism and identification of ANGPTL6 as a new diagnostic and prognostic biomarker

Although an association between the cytochrome P4502D6 (CYP2D6) *10 (100C>T) polymorphism and hepatocellular carcinoma (HCC) is known, the mechanism remains unclear. Here we aimed to explore mechanisms of CYP2...

Authors: Guiming Hu, Fei Gao, Guanzhe Wang, Yan Fang, Yuanyuan Guo, Jun Zhou, Yuhan Gu, Cunzhen Zhang, Na Gao, Qiang Wen and Hailing Qiao

Age and gender differences in ACE2 and TMPRSS2 expressions in oral epithelial cells

SARS-CoV-2, which has brought a huge negative impact on the world since the end of 2019, is reported to invade cells using the spike (S) protein to bind to angiotensin-converting enzyme II (ACE2) receptors on ...

Authors: Jinfeng Peng, Jiwei Sun, Jiajia Zhao, Xuliang Deng, Fengyuan Guo and Lili Chen

Move to health-a holistic approach to the management of chronic low back pain: an intervention and implementation protocol developed for a pragmatic clinical trial

The prevalence of chronic pain conditions is growing. Low back pain was the primary cause of disability worldwide out of 156 conditions assessed between 1990 and 2016, according to the Global Burden of Disease...

Authors: Daniel I. Rhon, Julie M. Fritz, Tina A. Greenlee, Katie E. Dry, Rachel J. Mayhew, Mary C. Laugesen, Edita Dragusin and Deydre S. Teyhen

Lactobacillus paracasei R3 protects against dextran sulfate sodium (DSS)-induced colitis in mice via regulating Th17/Treg cell balance

Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis (UC) and Crohn's Disease, are most often a polygenic disorder with contributions from the intestinal microbiome, defects in barrier funct...

Authors: Juan Huang, Ziyan Yang, Yanyun Li, Xingxing Chai, Yanfang Liang, Bihua Lin, Ziyu Ye, Shaobing Zhang, Zhengping Che, Hailiang Zhang, Xueying Zhang, Zhao Zhang, Tao Chen, Weiqing Yang and Jincheng Zeng

Urinary small extracellular vesicles derived CCL21 mRNA as biomarker linked with pathogenesis for diabetic nephropathy

Diabetic nephropathy (DN) is a leading cause of renal failure, whereas the effective and early diagnostic biomarkers are still lacking.

Authors: Ye Feng, Xin Zhong, Hai-Feng Ni, Cui Wang, Tao-Tao Tang, Li-Ting Wang, Kai-Yun Song, Ri-Ning Tang, Hong Liu, Bi-Cheng Liu and Lin-Li Lv

Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine

A growing body of evidence suggests that transcutaneous auricular vagus nerve stimulation (taVNS) may relieve symptoms of migraineurs. Frequency is one of the key stimulation parameters. The aim of this study ...

Authors: Jin Cao, Yue Zhang, Hui Li, Zhaoxian Yan, Xian Liu, Xiaoyan Hou, Weicui Chen, Sierra Hodges, Jian Kong and Bo Liu

Fibroblast growth factor 11 (FGF11) promotes non-small cell lung cancer (NSCLC) progression by regulating hypoxia signaling pathway

Accumulating evidence highlights the critical roles of fibroblast growth factors (FGFs) in regulating the progression of multiple human cancers, including non-small cell lung cancer (NSCLC). In this study, we ...

Authors: Xiaowei Wu, Minjie Li, Ying Li, Yu Deng, Shun Ke, Fan Li, Yujin Wang and Shuchang Zhou

Identification of tumor antigens and immune subtypes in lower grade gliomas for mRNA vaccine development

As an important part of tumor immunotherapy for adjunct, therapeutic tumor vaccines have been effective against multiple solid cancers, while their efficacy against lower grade glioma (LGG) remains undefined. ...

Authors: Liguo Ye, Long Wang, Ji’an Yang, Ping Hu, Chunyu Zhang, Shi’ao Tong, Zhennan Liu and Daofeng Tian

Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice

Given the clinical low efficient treatment based on mono-brain-target design in Alzheimer’s disease (AD) and an increasing emphasis on microbiome-gut-brain axis which was considered as a crucial pathway to aff...

Authors: Jie Gao, Nian Zhou, Yongkang Wu, Mengna Lu, Qixue Wang, Chenyi Xia, Mingmei Zhou and Ying Xu

Association of serum 25-OH-vitamin D level with FTO and IRX3 genes expression in obese and overweight boys with different FTO rs9930506 genotypes

The roles of FTO gene and the level of serum 25-OH-vitamin D in obesity are frequently reported. This study aimed to investigate the interactions of serum 25-OH-vitamin D level, FTO and IRX3 genes expression, ...

Authors: Maryam Gholamalizadeh, Saeid Doaei, Zohreh Mokhtari, Vahideh Jalili, Fatemeh Bourbour, Saeed Omidi, Kamal Ebrahimi, Naser Kalantari, Sheyda Abdi, Ghasem Azizi Tabesh, Mohammad Naimi Joubani, Esmaeil Roohbakhsh and Seyed Alireza Mosavi Jarrahi

Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling

Silicosis is one of the most common occupational pulmonary fibrosis caused by respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a commonly used biguanide antidiabetic agent,...

Authors: Demin Cheng, Qi Xu, Yue Wang, Guanru Li, Wenqing Sun, Dongyu Ma, Siyun Zhou, Yi Liu, Lei Han and Chunhui Ni

Deep learning-based predictive biomarker of pathological complete response to neoadjuvant chemotherapy from histological images in breast cancer

Pathological complete response (pCR) is considered a surrogate endpoint for favorable survival in breast cancer patients treated with neoadjuvant chemotherapy (NAC). Predictive biomarkers of treatment response...

Authors: Fengling Li, Yongquan Yang, Yani Wei, Ping He, Jie Chen, Zhongxi Zheng and Hong Bu

Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages

Tumor-associated macrophages (TAM) are immunosuppressive cells that contribute to impaired anti-cancer immunity. Iron plays a critical role in regulating macrophage function. However, it is still elusive wheth...

Authors: Jia-Lei Sun, Ning-Ping Zhang, Ru-Chen Xu, Guang-Cong Zhang, Zhi-Yong Liu, Weinire Abuduwaili, Fu Wang, Xiang-Nan Yu, Xuan Shi, Guang-Qi Song, Hao Wu, Tao-Tao Liu, Xi-Zhong Shen, Bin Deng, Shu-Qiang Weng, Ling Dong…

Multi-omics network characterization reveals novel microRNA biomarkers and mechanisms for diagnosis and subtyping of kidney transplant rejection

Kidney transplantation is an optimal method for treatment of end-stage kidney failure. However, kidney transplant rejection (KTR) is commonly observed to have negative effects on allograft function. MicroRNAs ...

Authors: Yuxin Lin, Liangliang Wang, Wenqing Ge, Yu Hui, Zheng Zhou, Linkun Hu, Hao Pan, Yuhua Huang and Bairong Shen

Correction to: The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinoma

Authors: Lin Shui, Xiaofen Li, Yang Peng, Jiangfang Tian, Shuangshuang Li, Du He, Ang Li, Bole Tian, Mao Li, Heli Gao, Ning An, Cheng Yi and Dan Cao

Heparin-binding growth factor (HDGF) drives radioresistance in breast cancer by activating the STAT3 signaling pathway

Although reports implicate radioresistance as an important obstacle for the management of breast cancer, its molecular mechanism is elusive. Herein, we found that high HDGF levels are expressed significantly i...

Authors: Lingyun Qiu, Yan Ma, Xiaohua Chen, Liheng Zhou, Haibo Zhang, Guansheng Zhong, Lei Zhang and Jianming Tang

Potential scalp stimulation targets for mental disorders: evidence from neuroimaging studies

Mental disorders widely contribute to the modern global disease burden, creating a significant need for improvement of treatments. Scalp stimulation methods (such as scalp acupuncture and transcranial electric...

Authors: Jin Cao, Thalia Celeste Chai-Zhang, Yiting Huang, Maya Nicole Eshel and Jian Kong

ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis

We tried to elaborate the molecular mechanism of ETS-like transcription factor 4 (ELK4) affecting gastric cancer (GC) progression through M2 polarization of macrophages mediated by lysine-specific demethylase ...

Authors: Lei Zheng, Hongmei Xu, Ya Di, Lanlan Chen, Jiao Liu, Liying Kang and Liming Gao

Correction to: Anti-migraine agents from an immunological point of view

Authors: Mushref Bakri Assas

Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice

To examine the effects of BI 1029539 (GS-248), a novel selective human microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, in experimental models of acute lung injury (ALI) and sepsis in transgenic mice co...

Authors: Malarvizhi Gurusamy, Saeed Nasseri, Dileep Reddy Rampa, Huiying Feng, Dongwon Lee, Anton Pekcec, Henri Doods and Dongmei Wu

Bcl-2-associated transcription factor 1 Ser290 phosphorylation mediates DNA damage response and regulates radiosensitivity in gastric cancer

DNA damage response plays critical roles in tumor pathogenesis and radiotherapy resistance. Protein phosphorylation is a critical mechanism in regulation of DNA damage response; however, the key mediators for ...

Authors: Jia Liu, Jingyi Li, Zhao Sun, Yangmiao Duan, Fengqin Wang, Guangwei Wei and Jing-Hua Yang

CYB561D2 up-regulation activates STAT3 to induce immunosuppression and aggression in gliomas

Fine tuned balance of reactive oxygen species (ROS) is essential for tumor cells and tumor cells use immune checkpoints to evade attack form immunity system. However, it’s unclear whether there is any crosstal...

Authors: Bangbao Tao, Juanhong Shi, Shuai Shuai, Haiyan Zhou, Hongxia Zhang, Bin Li, Xiaoqiang Wang, Guohui Li, Hua He and Jun Zhong

Fe₃O₄ magnetic nanoparticle-enhanced radiotherapy for lung adenocarcinoma via delivery of siBIRC5 and AS-ODN

Radiotherapy is the mainstay treatment for lung adenocarcinoma, yet remains highly susceptible to resistance. Fe₃O₄ magnetic nanoparticles (MNPs) possess the ability to induce biological therapeutic effects. Here...

Authors: Shuzhen Chen, Fushi Han, Dongdong Huang, Jinqian Meng, Jiapeng Chu, Meng Wang and Peijun Wang

Analysis of lncRNA-miRNA-mRNA expression pattern in heart tissue after total body radiation in a mouse model

Radiation therapy is integral to effective thoracic cancer treatments, but its application is limited by sensitivity of critical organs such as the heart. The impacts of acute radiation-induced damage and its ...

Authors: Molykutty J. Aryankalayil, Shannon Martello, Michelle A. Bylicky, Sunita Chopra, Jared M. May, Aman Shankardass, Laurel MacMillan, Landy Sun, Jaleal Sanjak, Claire Vanpouille-Box, Iris Eke and C. Norman Coleman

BCL7A as a novel prognostic biomarker for glioma patients

Glioma is the most common primary brain tumor and represents one of the most aggressive and lethal types of human cancer. BCL7 family has been found in several cancer types and could be involved in tumor progr...

Authors: Junhui Liu, Lun Gao, Baowei Ji, Rongxin Geng, Jing Chen, Xiang Tao, Qiang Cai and Zhibiao Chen

DEAD-box helicase 27 enhances stem cell-like properties with poor prognosis in breast cancer

Although the rapid development of diagnosis and treatment has improved prognosis in early breast cancer, challenges from different therapeutic response remain due to breast cancer heterogeneity. DEAD-box helic...

Authors: Shan Li, Jinfei Ma, Ang Zheng, Xinyue Song, Si Chen and Feng Jin

MYBL2-induced PITPNA-AS1 upregulates SIK2 to exert oncogenic function in triple-negative breast cancer through miR-520d-5p and DDX54

In recent years, long non-coding RNAs (lncRNAs) have attracted much attention because of its regulatory role in occurrence and progression of tumors, including triple-negative breast cancer (TNBC). LncRNA PITP...

Authors: Bolong Liu, Pingbo Yao, Feng Xiao, Jianjin Guo, Lianghui Wu and Yong Yang

E3 ubiquitin ligase TRIM29 promotes pancreatic cancer growth and progression via stabilizing Yes-associated protein 1

Pancreatic cancer (PC) is one of the most fatal digestive system cancers. tripartite motif-29 (TRIM29) has been reported as oncogene in several human cancers. However, the precise role and underlying signal ca...

Authors: Xueqiang Deng, Xiaowei Fu, Hong Teng, Lu Fang, Bo Liang, Rengui Zeng, Lian Chen and Yeqing Zou

Identification of proteins associated with development of psoriatic arthritis in peripheral blood mononuclear cells: a quantitative iTRAQ-based proteomics study

Biomarkers for distinguishing psoriatic arthritis (PsA) from psoriasis without arthritis (PsO) are still lacking.

Authors: Jie Zhu, Ling Han, Ruilai Liu, Zhenghua Zhang, Qiong Huang, Xu Fang, Ke Yang, Guiqin Huang, Zhizhong Zheng, Nikhil Yawalkar, Hui Deng and Kexiang Yan

Immune and stromal scoring system associated with tumor microenvironment and prognosis: a gene-based multi-cancer analysis

Tumor microenvironment (TME) is associated with tumor progression and prognosis. Previous studies provided tools to estimate immune and stromal cell infiltration in TME. However, there is still a lack of singl...

Authors: Zihang Zeng, Jiali Li, Jianguo Zhang, Yangyi Li, Xingyu Liu, Jiarui Chen, Zhengrong Huang, Qiuji Wu, Yan Gong and Conghua Xie

Correction to: Characterization of terminal-ileal and colonic Crohn’s disease in treatment-naïve paediatric patients based on transcriptomic profile using logistic regression

Authors: Ilkyu Park, Jaeeun Jung, Sugi Lee, Kunhyang Park, Jea-Woon Ryu, Mi-Young Son, Hyun-Soo Cho and Dae-Soo Kim

Clinical outcome of renal cancer patients who early interrupted immunotherapy due to serious immune-related adverse events. Meet-Uro 13 trial on behalf of the MeetUro investigators

Severe immune-related Adverse Events (irAEs) develop in 10–27% of patients treated with Immune-Oncology (IO) [Powles (Lancet 391:748–757, 2018); Galsky (Lancet 395:1547–1557, 2020); Haanen (Ann Oncol 28:119–14...

Authors: Marco Stellato, Giuseppe Procopio, Ugo De Giorgi, Marco Maruzzo, Davide Bimbatti, Alessia Mennitto, Andrea Sbrana, Giandomenico Roviello, Chiara Casadei, Pierangela Sepe, Sandro Pignata and Daniele Santini

Emerging trends and focus of human gastrointestinal microbiome research from 2010–2021: a visualized study

The gastrointestinal microbiome is an important component of the human body and is closely related to human health and disease. This study describes the hotspots of the human gastrointestinal microbiome resear...

Authors: Xingzhu Yuan, Chengting Chang, Xinrong Chen and Ka Li

Extracellular vesicle-derived AEBP1 mRNA as a novel candidate biomarker for diabetic kidney disease

A novel and improved methodology is still required for the diagnosis of diabetic kidney disease (DKD). The aim of the present study was to identify novel biomarkers using extracellular vesicle (EV)-derived mRN...

Authors: Yiying Tao, Xing Wei, Yue Yue, Jiaxin Wang, Jianzhong Li, Lei Shen, Guoyuan Lu, Yang He, Shidi Zhao, Fan Zhao, Zhen Weng, Xiahong Shen and Ling Zhou

Cancer-associated fibroblast infiltration in gastric cancer: the discrepancy in subtypes pathways and immunosuppression

General role of cancer-associated fibroblast (CAF) and its infiltration characteristics in gastric cancer remains to be unknown.

Authors: Xu Liu, Li Yao, Jingkun Qu, Lin Liu, Ning Lu, Jiansheng Wang and Jia Zhang

Chronotype: what role in the context of gastroenteropancreatic neuroendocrine tumors?

Chronotype is defined as a trait determining the subject circadian preference in behavioral and biological rhythms relative to external light–dark cycle. Although individual differences in chronotype have been...

Authors: Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Roberta Modica, Daniela Laudisio, Sara Aprano, Antongiulio Faggiano, Annamaria Colao and Silvia Savastano

Genetic alterations and functional networks of m6A RNA methylation regulators in pancreatic cancer based on data mining

Pancreatic cancer is a fatal malignancy of the digestive system and the 5-year survival rate remains low. Therefore, new molecular therapeutic targets are required to improve treatments, prognosis, and the sur...

Authors: Juan Zeng, Heying Zhang, Yonggang Tan, Zhe Wang, Yunwei Li and Xianghong Yang

Development and validation of a score to predict mortality in ICU patients with sepsis: a multicenter retrospective study

Early and accurate identification of septic patients at high risk for ICU mortality can help clinicians make optimal clinical decisions and improve the patients’ outcomes. This study aimed to develop and valid...

Authors: Jie Weng, Ruonan Hou, Xiaoming Zhou, Zhe Xu, Zhiliang Zhou, Peng Wang, Liang Wang, Chan Chen, Jinyu Wu and Zhiyi Wang

An explainable supervised machine learning predictor of acute kidney injury after adult deceased donor liver transplantation

Early prediction of acute kidney injury (AKI) after liver transplantation (LT) facilitates timely recognition and intervention. We aimed to build a risk predictor of post-LT AKI via supervised machine learning...

Authors: Yihan Zhang, Dong Yang, Zifeng Liu, Chaojin Chen, Mian Ge, Xiang Li, Tongsen Luo, Zhengdong Wu, Chenguang Shi, Bohan Wang, Xiaoshuai Huang, Xiaodong Zhang, Shaoli Zhou and Ziqing Hei

Analysis of microbial differences in amniotic fluid between advanced and normal age pregnant women

Authors: Ya Wang, Chunyu Luo, Yiwei Cheng, Li Li, Dong Liang, Ping Hu and Zhengfeng Xu

Analysis of immune cell components and immune-related gene expression profiles in peripheral blood of patients with type 1 diabetes mellitus

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease caused by severe loss of pancreatic β cells. Immune cells are key mediators of β cell destruction. This study attempted to investigate the role o...

Authors: Jian Lin, Yuanhua Lu, Bizhou Wang, Ping Jiao and Jie Ma

Self-supervised deep learning model for COVID-19 lung CT image segmentation highlighting putative causal relationship among age, underlying disease and COVID-19

Coronavirus disease 2019 (COVID-19) is very contagious. Cases appear faster than the available Polymerase Chain Reaction test kits in many countries. Recently, lung computerized tomography (CT) has been used a...

Authors: Daryl L. X. Fung, Qian Liu, Judah Zammit, Carson Kai-Sang Leung and Pingzhao Hu

Constipation induced gut microbiota dysbiosis exacerbates experimental autoimmune encephalomyelitis in C57BL/6 mice

Constipation is a common gastrointestinal dysfunction which has a potential impact on people's immune state and their quality of life. Here we investigated the effects of constipation on experimental autoimmun...

Authors: Xiuli Lin, Yingying Liu, Lili Ma, Xiaomeng Ma, Liping Shen, Xueying Ma, Zhaoyu Chen, Hao Chen, Donghong Li, Zhumin Su and Xiaohong Chen

N6-Methyladenosine RNA modification in cerebrospinal fluid as a novel potential diagnostic biomarker for progressive multiple sclerosis

Progressive multiple sclerosis (PMS) is an uncommon and severe subtype of MS that worsens gradually and leads to irreversible disabilities in young adults. Currently, there are no applicable or reliable biomar...

Authors: Fei Ye, Tianzhu Wang, Xiaoxin Wu, Jie Liang, Jiaoxing Li and Wenli Sheng

Sarcopenia associates with SNAP-25 SNPs and a miRNAs profile which is modulated by structured rehabilitation treatment

Sarcopenia is a loss of muscle mass and strength causing disability, morbidity, and mortality in older adults, which is characterized by alterations of the neuromuscular junctions (NMJs). SNAP-25 is essential ...

Authors: Simone Agostini, Roberta Mancuso, Andrea Saul Costa, Franca Rosa Guerini, Fabio Trecate, Rossella Miglioli, Elisabetta Menna, Beatrice Arosio and Mario Clerici

Hsa_circ_0000520 overexpression increases CDK2 expression via miR-1296 to facilitate cervical cancer cell proliferation

Circular RNA (circRNA) has been demonstrated to participate in cervical cancer development. In this study, we analyzed the role of hsa_circ_0000520 in cervical cancer.

Authors: Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai and Donghua Gu

Characterization of genomic alterations in Chinese colorectal cancer patients with liver metastases

The exploration of genomic alterations in Chinese colorectal liver metastasis (CRLM) is limited, and corresponding genetic biomarkers for patient’s perioperative management are still lacking. This study aims t...

Authors: Hong-Wei Wang, Xiao-Luan Yan, Li-Jun Wang, Meng-Huan Zhang, Chun-He Yang, Wei-Liu, Ke-Min Jin, Quan Bao, Juan Li, Kun Wang and Bao-Cai Xing

The role of exosomes in lung cancer metastasis and clinical applications: an updated review

Lung cancer is the leading cause of cancer-associated deaths accounting for 24% of all cancer deaths. As a crucial phase of tumor progression, lung cancer metastasis is linked to over 70% of these mortalities....

Authors: Lei Yin, Xiaotian Liu, Xuejun Shao, Tao Feng, Jun Xu, Qi Wang and Shenghao Hua

Model for in-vivo estimation of stiffness of tibiofemoral joint using MR imaging and FEM analysis

Appropriate structural and material properties are essential for finite-element-modeling (FEM). In knee FEM, structural information could extract through 3D-imaging, but the individual subject’s tissue materia...

Authors: Sandeep Panwar Jogi, Rafeek Thaha, Sriram Rajan, Vidur Mahajan, Vasantha Kumar Venugopal, Anup Singh and Amit Mehndiratta