Patient-targeted molecular therapies

Section edited by Francesco Chiappelli and Francesco Piva

The mission of this section is to enrich the overall mandate of the journal through effectively capturing the growing sector of molecular targeted therapies with broad therapeutic applicability, benefiting from a patient-centered outcomes research focus and translational effectiveness approach, to generate adequate information during research and early development stages, as well as consensus on the best available evidence.

This section has a unique and defining objective and rationale relative to the other sections that focus primarily on translational immunology and oncology. In contrast, this section will add the complementary discourse between translational research and translational effectiveness. In doing so, it will expand the overall vision of the journal, and address current, timely and cutting edge research and reviews about patient-centered targeted therapies, in context of translating cost and benefit effectiveness to specific clinical settings.

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  1. Research

    Basigin-2 is the predominant basigin isoform that promotes tumor cell migration and invasion and correlates with poor prognosis in epithelial ovarian cancer

    Basigin, which has four isoforms, has been demonstrated to be involved in progression of various human cancers. The aim of this study was to examine the prognostic value of basigin-2 protein expression in epit...

    Shu-Hua Zhao, Yu Wang, Li Wen, Zhen-Bo Zhai, Zhen-Hua Ai, Nian-Ling Yao, Li Wang, Wen-Chao Liu, Bi-Liang Chen, Yu Li and Hong Yang

    Journal of Translational Medicine 2013 11:92

    Published on: 8 April 2013

  2. Research

    Molecular mechanisms of anti-tumor properties of P276-00 in head and neck squamous cell carcinoma

    Tumors of the head and neck present aggressive pathological behavior in patients due to high expression of CDK/CCND1 proteins. P276-00, a novel CDK inhibitor currently being tested in clinic, inhibits growth o...

    Prabha B Mishra, Aurelio S Lobo, Kalpana S Joshi, Maggie J Rathos, Gopinath A Kumar and Muralidhara Padigaru

    Journal of Translational Medicine 2013 11:42

    Published on: 18 February 2013

  3. Research

    Prognostication of prostate cancer based on TOP2A protein and gene assessment: TOP2A in prostate cancer

    TOP2A encodes for topoisomerase IIα, a nuclear enzyme that controls DNA topological structure and cell cycle progression. This enzyme is a marker of cell proliferation in normal and neoplastic tissues; however, l...

    Marina França de Resende, Samantha Vieira, Ludmilla Thomé Domingos Chinen, Francesco Chiappelli, Francisco Paulo da Fonseca, Gustavo Cardoso Guimarães, Fernando Augusto Soares, Ivan Neves, Simone Pagotty, Peter A Pellionisz, Andre Barkhordarian, Xenia Brant and Rafael Malagoli Rocha

    Journal of Translational Medicine 2013 11:36

    Published on: 11 February 2013

  4. Research

    Somatostatin-based radiotherapy with [90Y-DOTA]-TOC in neuroendocrine tumors: long-term outcome of a phase I dose escalation study

    We describe the long-term outcome after clinical introduction and dose escalation of somatostatin receptor targeted therapy with [90Y-DOTA]-TOC in patients with metastasized neuroendocrine tumors.

    Nicolas Marincek, Ann-Catherine Jörg, Philippe Brunner, Christian Schindler, Michael T Koller, Christoph Rochlitz, Jan Müller-Brand, Helmut R Maecke, Matthias Briel and Martin A Walter

    Journal of Translational Medicine 2013 11:17

    Published on: 15 January 2013

  5. Research

    Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients

    Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor with poor clinical outcome. Identification and development of new markers could be beneficial for the diagnosis and prognosis of GBM ...

    Shuwei Qiu, Sheng Lin, Dan Hu, Yimin Feng, Yang Tan and Ying Peng

    Journal of Translational Medicine 2013 11:10

    Published on: 9 January 2013

  6. Methodology

    NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways

    Animal models of human inflammatory diseases have limited predictive quality for human clinical trials for various reasons including species specific activation mechanisms and the immunological background of t...

    Maryam Zadeh-Khorasani, Thomas Nolte, Thomas D Mueller, Markos Pechlivanis, Franziska Rueff, Andreas Wollenberg, Gert Fricker, Eckhard Wolf, Matthias Siebeck and Roswitha Gropp

    Journal of Translational Medicine 2013 11:4

    Published on: 7 January 2013

  7. Research

    Poorly differentiated synovial sarcoma is associated with high expression of enhancer of zeste homologue 2 (EZH2)

    Enhancer of zeste homologue 2 (EZH2) is a polycomb group (PcG) family protein. Acting as a histone methyltransferase it plays crucial roles in maintaining epigenetic stem cell signature, while its deregulation...

    Yi-Che Changchien, Péter Tátrai, Gergő Papp, Johanna Sápi, László Fónyad, Miklós Szendrői, Zsuzsanna Pápai and Zoltán Sápi

    Journal of Translational Medicine 2012 10:216

    Published on: 30 October 2012

  8. Research

    Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma

    Melanoma antigen D1 (MAGED1) is a member of the type II melanoma antigen (MAGE) family. The down-regulation of MAGED1 expression has been shown in breast carcinoma cell lines and in glioma stem cells and may p...

    Zhao-lei Zeng, Wen-jing Wu, Jing Yang, Zhen-jie Tang, Dong-liang Chen, Miao-zhen Qiu, Hui-yan Luo, Zhi-qiang Wang, Ying Jin, De-shen Wang and Rui-hua Xu

    Journal of Translational Medicine 2012 10:181

    Published on: 31 August 2012

  9. Research

    Prognostic significance of c-KIT in vulvar cancer: bringing this molecular marker from bench to bedside

    Vulvar carcinomas are rare tumors, and there is limited data regarding molecular alterations. To our knowledge there are no published studies on c-KIT and squamous cell carcinomas of the vulva (VSCC). Although...

    Beatriz de Melo Maia, André Mourão Lavorato-Rocha, Iara Sant’Ana Rodrigues, Glauco Baiocchi, Flávia Munhoz Cestari, Monica Maria Stiepcich, Ludmila Thomé Domingues Chinen, Kátia C Carvalho, Fernando Augusto Soares and Rafael Malagoli Rocha

    Journal of Translational Medicine 2012 10:150

    Published on: 28 July 2012

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