Skip to main content

Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al


The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

Page 5 of 6

  1. As the most common form of lymphoma, diffuse large B-cell lymphoma (DLBCL) is a clinical highly heterogeneous disease with variability in therapeutic outcomes and biological features. It is a challenge to iden...

    Authors: Jinglei Hu, Jing Xu, Muqiao Yu, Yongchao Gao, Rong Liu, Honghao Zhou and Wei Zhang
    Citation: Journal of Translational Medicine 2020 18:144
    Content type: Research Published on:

  2. The rise in incidence and mortality of gastrointestinal mixed adenoneuroendocrine carcinoma (MANEC) has not been well focused. The aim of our study was to examine epidemiological trends in incidence and incide...

    Authors: Jiakun Wang, Aoxiao He, Qian Feng, Ping Hou, Junjun Wu, Zhihao Huang, Zhouqing Xiao, Chi Sun, Wenjun Liao and Linquan Wu
    Citation: Journal of Translational Medicine 2020 18:128
    Content type: Research Published on:

  3. Research has associated human epidermal growth factor receptor (HER2) with glucose and lipid metabolism. However, the association between circulating HER2 levels and coronary artery disease (CAD) remains to be...

    Authors: Wen Jian, Chun-Mei Wei, Jia-Hui Guan, Chang-Hua Mo, Yu-Tao Xu, Wen-Bo Zheng, Lang Li and Chun Gui
    Citation: Journal of Translational Medicine 2020 18:124
    Content type: Research Published on:

  4. The performance of previously published glomerular filtration rate (GFR) estimation equations degrades when directly used in Chinese population. We incorporated more independent variables and using complicated...

    Authors: Ningshan Li, Hui Huang, Han-Zhu Qian, Peijia Liu, Hui Lu and Xun Liu
    Citation: Journal of Translational Medicine 2020 18:120
    Content type: Research Published on:

  5. Prostate cancer (PCa) is a common malignant tumor with increasing incidence and high heterogeneity among males worldwide. In the era of big data and artificial intelligence, the paradigm of biomarker discovery...

    Authors: Yuxin Lin, Xiaojun Zhao, Zhijun Miao, Zhixin Ling, Xuedong Wei, Jinxian Pu, Jianquan Hou and Bairong Shen
    Citation: Journal of Translational Medicine 2020 18:119
    Content type: Review Published on:

  6. The identity management is a central component in medical research. Patients are recruited from various sites, which requires an error tolerant record linkage method, to ensure that patients are registered onl...

    Authors: Christopher Hampf, Lars Geidel, Norman Zerbe, Martin Bialke, Dana Stahl, Arne Blumentritt, Thomas Bahls, Peter Hufnagl and Wolfgang Hoffmann
    Citation: Journal of Translational Medicine 2020 18:86
    Content type: Methodology Published on:

  7. Tumour cells interfere with normal immune functions by affecting the expression of some immune-related genes, which play roles in the prognosis of cancer patients. In recent years, immunotherapy for tumours ha...

    Authors: Xiaoshun Shi, Ruidong Li, Xiaoying Dong, Allen Menglin Chen, Xiguang Liu, Di Lu, Siyang Feng, He Wang and Kaican Cai
    Citation: Journal of Translational Medicine 2020 18:55
    Content type: Research Published on:

  8. Accurate lymph node metastasis (LNM) prediction in colorectal cancer (CRC) patients is of great significance for treatment decision making and prognostic evaluation. We aimed to develop and validate a clinical...

    Authors: Menglei Li, Jing Zhang, Yibo Dan, Yefeng Yao, Weixing Dai, Guoxiang Cai, Guang Yang and Tong Tong
    Citation: Journal of Translational Medicine 2020 18:46
    Content type: Research Published on:

  9. During pregnancy in humans, the physiology of the mother and foetus are finely regulated by many factors. Inappropriate regulation can result in pregnancy disorders, such as complications and foetal abnormalit...

    Authors: Haiou Yang, Qianqian Ma, Yu Wang and Zhenhua Tang
    Citation: Journal of Translational Medicine 2020 18:32
    Content type: Review Published on:

  10. A correct perception of the body image, as defined by comparison with actual anthropometric analyses, is crucial to ensure the best possible nutritional status of each individual. Bioimpedance analysis (BIA) r...

    Authors: Luciana Zaccagni, Natascia Rinaldo, Barbara Bramanti, Jessica Mongillo and Emanuela Gualdi-Russo
    Citation: Journal of Translational Medicine 2020 18:20
    Content type: Research Published on:

  12. Artificial intelligence (AI), with its seemingly limitless power, holds the promise to truly revolutionize patient healthcare. However, the discourse carried out in public does not always correlate with the ac...

    Authors: M.-C. Laï, M. Brian and M.-F. Mamzer
    Citation: Journal of Translational Medicine 2020 18:14
    Content type: Research Published on:

  13. The Spanish HIV HGM BioBank is of great relevance for basic and clinical investigation, and for those groups trying to establish large networks focused on investigation on specific clinical problems. The colle...

    Authors: Irene Consuegra Fernández, Isabel García Merino and María Ángeles Muñoz-Fernández
    Citation: Journal of Translational Medicine 2020 18:6
    Content type: Research Published on:

  14. Inflammatory bowel disease (IBD) was emerging as a worldwide epidemic disease, and the advanced therapy changed the clinical course and possibly the outcomes. Our previous study reported a higher mortality rat...

    Authors: Wei-Chen Lin, Meng-Tzu Weng, Chien-Chih Tung, Yuan-Ting Chang, Yew-Loong Leong, Yu-Ting Wang, Horng-Yuan Wang, Jau-Min Wong and Shu-Chen Wei
    Citation: Journal of Translational Medicine 2019 17:414
    Content type: Research Published on:

  15. The current study aimed to construct competing endogenous RNA (ceRNA) regulation network and develop two precision medicine predictive tools for colorectal cancer (CRC).

    Authors: Zhiqiao Zhang, Tingshan He, Liwen Huang, Yanling Ouyang, Jing Li, Yiyan Huang, Peng Wang and Jianqiang Ding
    Citation: Journal of Translational Medicine 2019 17:405
    Content type: Research Published on:

  16. Since both genomic and environmental factors are involved in obesity etiology, several studies about the influence of adiposity on both nuclear DNA and mitochondrial DNA methylation patterns have been carried ...

    Authors: Laura Bordoni, Vanessa Smerilli, Cinzia Nasuti and Rosita Gabbianelli
    Citation: Journal of Translational Medicine 2019 17:399
    Content type: Research Published on:

  19. Understanding cancer heterogeneity, its temporal evolution over time, and the outcomes of guided treatment depend on accurate data collection in a context of routine clinical care. We have developed a hospital...

    Authors: Grigory Sidorenkov, Janny Nagel, Coby Meijer, Jacko J. Duker, Harry J. M. Groen, Gyorgy B. Halmos, Maaike H. M. Oonk, Rene J. Oostergo, Bert van der Vegt, Max J. H. Witjes, Marcel Nijland, Klaas Havenga, John H. Maduro, Jourik A. Gietema and Gertruida H. de Bock
    Citation: Journal of Translational Medicine 2019 17:374
    Content type: Methodology Published on:

  20. Subarachnoid hemorrhage (SAH) accounts for 4.4% of cerebral vascular disease, which is one of the leading causes of death in China. Rupture of intracranial aneurysms (IAs) is the most common cause of SAH. The ...

    Authors: Haixiao Liu, Wei Guo, Sishi Xiang, Peng Hu, Feifei Sun, Junmei Gao, Xiaoyang Zhang, Ping Wang, Wenting Jing, Lei Zhang, Xinjian Yang, Chuanzhi Duan, Min He, Hongqi Zhang and Yan Qu
    Citation: Journal of Translational Medicine 2019 17:349
    Content type: Protocol Published on:

  21. Genomic and radiomic data integration, namely radiogenomics, can provide meaningful knowledge in cancer diagnosis, prognosis and treatment. Despite several data structures based on multi-layer architecture pro...

    Authors: Mario Zanfardino, Monica Franzese, Katia Pane, Carlo Cavaliere, Serena Monti, Giuseppina Esposito, Marco Salvatore and Marco Aiello
    Citation: Journal of Translational Medicine 2019 17:337
    Content type: Review Published on:

  22. Best vitelliform macular dystrophy (BVMD) is an autosomal dominant macular degeneration. The typical central yellowish yolk-like lesion usually appears in childhood and gradually worsens. Most cases are caused...

    Authors: Vladimir Frecer, Giancarlo Iarossi, Anna Paola Salvetti, Paolo Enrico Maltese, Giulia Delledonne, Marta Oldani, Giovanni Staurenghi, Benedetto Falsini, Angelo Maria Minnella, Lucia Ziccardi, Adriano Magli, Leonardo Colombo, Fabiana D’Esposito, Jan Miertus, Francesco Viola, Marcella Attanasio…
    Citation: Journal of Translational Medicine 2019 17:330
    Content type: Research Published on:

  23. Post-transcriptional modifications have been recently expanded with the addition of RNA editing, which is predominantly mediated by adenosine and cytidine deaminases acting on DNA and RNA. Here, we review the ...

    Authors: Theodoulakis Christofi and Apostolos Zaravinos
    Citation: Journal of Translational Medicine 2019 17:319
    Content type: Review Published on:

  24. Infertility has become a global health issue with the number of couples seeking in vitro fertilization (IVF) worldwide continuing to rise. Some couples remain childless after several IVF cycles. Women undergoi...

    Authors: Jiahui Qiu, Pingping Li, Meng Dong, Xing Xin and Jichun Tan
    Citation: Journal of Translational Medicine 2019 17:317
    Content type: Research Published on:

  25. Wearable smart watches provide large amount of real-time data on the environmental state of the users and are useful to determine risk factors for onset and progression of myopia. We aim to evaluate the effica...

    Authors: Bin Ye, Kangping Liu, Siting Cao, Padmaja Sankaridurg, Wayne Li, Mengli Luan, Bo Zhang, Jianfeng Zhu, Haidong Zou, Xun Xu and Xiangui He
    Citation: Journal of Translational Medicine 2019 17:314
    Content type: Methodology Published on:

  26. Estrogen receptors (ERs) are thought to play an important role in non-small cell lung cancer (NSCLC). However, the effect of ERs in NSCLC is still controversial and needs further investigation. A new considera...

    Authors: Xiujuan Gao, Yue Cai, Zhuo Wang, Wenjuan He, Sisi Cao, Rong Xu and Hui Chen
    Citation: Journal of Translational Medicine 2019 17:308
    Content type: Research Published on:

  27. Identifying how pain transitions from acute to chronic is critical in designing effective prevention and management techniques for patients’ well-being, physically, psychosocially, and financially. There is an...

    Authors: Jianzhong Su, Ying Du, Kelley Bevers, Pengcheng Xiao, John Licciardone, Marco Brotto and Robert J. Gatchel
    Citation: Journal of Translational Medicine 2019 17:306
    Content type: Research Published on:

  28. Trauma is the leading cause of mortality in humans below the age of 40. Patients injured by accidents frequently suffer severe multiple trauma, which is life-threatening and leads to death in many cases. In mu...

    Authors: Birte Weber, Ina Lackner, Melanie Haffner-Luntzer, Annette Palmer, Jochen Pressmar, Karin Scharffetter-Kochanek, Bernd Knöll, Hubert Schrezenemeier, Borna Relja and Miriam Kalbitz
    Citation: Journal of Translational Medicine 2019 17:305
    Content type: Review Published on:

  29. Emerging evidences show that microRNA (miRNA) plays an important role in many human complex diseases. However, considering the inherent time-consuming and expensive of traditional in vitro experiments, more an...

    Authors: Kai Zheng, Zhu-Hong You, Lei Wang, Yong Zhou, Li-Ping Li and Zheng-Wei Li
    Citation: Journal of Translational Medicine 2019 17:260
    Content type: Research Published on:

  30. Pooled testing, in which biological specimens from multiple subjects are combined into a testing pool and tested via a single test, is a common testing method for both surveillance and screening activities. Th...

    Authors: Ngoc T. Nguyen, Hrayer Aprahamian, Ebru K. Bish and Douglas R. Bish
    Citation: Journal of Translational Medicine 2019 17:252
    Content type: Research Published on:

  32. Drug development is currently hampered by high attrition rates; many developed treatments fail during clinical testing. Part of the attrition may be due to low animal-to-human translational success rates; so-c...

    Authors: Cathalijn H. C. Leenaars, Carien Kouwenaar, Frans R. Stafleu, André Bleich, Merel Ritskes-Hoitinga, Rob B. M. De Vries and Franck L. B. Meijboom
    Citation: Journal of Translational Medicine 2019 17:223
    Content type: Review Published on:

  33. Tumor necrosis factor α (TNFα) is a multifunctional cytokine with a potent pro-inflammatory effect. It is a validated therapeutic target molecule for several disorders related to autoimmunity and inflammation....

    Authors: Madhu Sudhana Saddala and Hu Huang
    Citation: Journal of Translational Medicine 2019 17:215
    Content type: Research Published on:

  35. Given the benefits of physical activity for health and survival, clinicians are seeking opportunities for cancer patients to become more active independent of rehabilitation programs that are small, time-limit...

    Authors: Catherine M. Sabiston, Angela J. Fong, Erin K. O’Loughlin and Sarkis Meterissian
    Citation: Journal of Translational Medicine 2019 17:206
    Content type: Research Published on:

  36. Serum uric acid (SUA) had been associated with incident hypertension, but it is uncertain whether and to what extent the effect of SUA is mediated by other metabolic factors.

    Authors: Zhi Cao, Yangyang Cheng, Shu Li, Hongxi Yang, Li Sun, Ying Gao, Pei Yu, Weidong Li and Yaogang Wang
    Citation: Journal of Translational Medicine 2019 17:202
    Content type: Research Published on:

  37. Lymph node status and liver metastasis (LIM) are important in determining the prognosis of early colon carcinoma. We attempted to develop and validate nomograms to predict lymph node metastasis (LNM) and LIM i...

    Authors: Yongcong Yan, Haohan Liu, Kai Mao, Mengyu Zhang, Qianlei Zhou, Wei Yu, Bingchao Shi, Jie Wang and Zhiyu Xiao
    Citation: Journal of Translational Medicine 2019 17:193
    Content type: Research Published on:

  38. The aim of the present review is to discuss how the promising field of biobanking can support health care research strategies. As the concept has evolved over time, biobanks have grown from simple biological s...

    Authors: Luigi Coppola, Alessandra Cianflone, Anna Maria Grimaldi, Mariarosaria Incoronato, Paolo Bevilacqua, Francesco Messina, Simona Baselice, Andrea Soricelli, Peppino Mirabelli and Marco Salvatore
    Citation: Journal of Translational Medicine 2019 17:172
    Content type: Review Published on:

  39. Predicting adverse drug reactions (ADRs) has become very important owing to the huge global health burden and failure of drugs. This indicates a need for prior prediction of probable ADRs in preclinical stages...

    Authors: Salma Jamal, Waseem Ali, Priya Nagpal, Sonam Grover and Abhinav Grover
    Citation: Journal of Translational Medicine 2019 17:171
    Content type: Research Published on:

  40. Compared with clinically functioning pituitary adenoma (FPA), clinically non-functioning pituitary adenoma (NFPA) lacks of detectable hypersecreting serum hormones and related symptoms which make it difficult ...

    Authors: Sen Cheng, Jiaqi Wu, Chuzhong Li, Yangfang Li, Chunhui Liu, Guilin Li, Wuju Li, Shuofeng Hu, Xiaomin Ying and Yazhuo Zhang
    Citation: Journal of Translational Medicine 2019 17:164
    Content type: Research Published on:

  41. The morbidity and mortality of patients with critical illnesses remain high in pulmonary critical care units and a poorly understood correlation between alterations of lipid elements and clinical phenomes rema...

    Authors: Danyan Gao, Linlin Zhang, Dongli Song, Jiapei Lv, Linyan Wang, Shuang Zhou, Yanjun Li, Tao Zeng, Yiming Zeng, Jiaqiang Zhang and Xiangdong Wang
    Citation: Journal of Translational Medicine 2019 17:162
    Content type: Research Published on:

  42. Esophageal cancer (EC) is one of the deadliest cancers worldwide. The contemporary strong increase of the adenocarcinomas in Western countries and the high mortality rates require the intensification of prospe...

    Authors: Doris Klingelhöfer, Yun Zhu, Markus Braun, Dörthe Brüggmann, Norman Schöffel and David A. Groneberg
    Citation: Journal of Translational Medicine 2019 17:150
    Content type: Research Published on:

  43. Glioblastomas (GB) are the most common and lethal primary brain tumors. Significant progress has been made toward identifying potential risk factors for GB and diagnostic and prognostic biomarkers. However, th...

    Authors: Anne Clavreul, Gwénaëlle Soulard, Jean-Michel Lemée, Marion Rigot, Pascale Fabbro-Peray, Luc Bauchet, Dominique Figarella-Branger and Philippe Menei
    Citation: Journal of Translational Medicine 2019 17:133
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2020 18:181

  44. The circadian clock governs a large variety of fundamentally important physiological processes in all three domains of life. Consequently, asynchrony in timekeeping mechanisms could give rise to cellular dysfu...

    Authors: Wai Hoong Chang and Alvina G. Lai
    Citation: Journal of Translational Medicine 2019 17:132
    Content type: Research Published on:

  45. Urinary protein quantification is critical for assessing the severity of chronic kidney disease (CKD). However, the current procedure for determining the severity of CKD is completed through evaluating 24-h ur...

    Authors: Jing Xiao, Ruifeng Ding, Xiulin Xu, Haochen Guan, Xinhui Feng, Tao Sun, Sibo Zhu and Zhibin Ye
    Citation: Journal of Translational Medicine 2019 17:119
    Content type: Research Published on:

  46. Extrahepatic metastasis is the independent risk factor of poor survival of primary hepatic carcinoma (PHC), and most occurs in the chest and abdomen. Currently, there is still no available method to predict th...

    Authors: Jia Hu, Ting Wang, Kun-He Zhang, Yi-Ping Jiang, Song Xu, Si-Hai Chen, Yu-Ting He, Hai-Liang Yuan and Yu-Qi Wang
    Citation: Journal of Translational Medicine 2019 17:117
    Content type: Research Published on:

  48. Chronic hepatitis C virus (HCV)-infection is a slowly debilitating and potentially fatal disease with a high estimated number of undiagnosed cases. Given the major advances in the treatment, detection of unrep...

    Authors: Markus Reiser, Bianka Wiebner and Jürgen Hirsch
    Citation: Journal of Translational Medicine 2019 17:94
    Content type: Research Published on:

  49. Artificial meniscal implants can be used to replace a severely injured meniscus after meniscectomy and restore the normal functionality of a knee joint. The aim of this paper was to design porous meniscal impl...

    Authors: Li-ya Zhu, Lan Li, Zong-an Li, Jian-ping Shi, Wen-lai Tang, Ji-quan Yang and Qing Jiang
    Citation: Journal of Translational Medicine 2019 17:89
    Content type: Research Published on:

  50. Similarities in the symptoms of chronic fatigue syndrome (CFS) and inflammatory bowel disease (IBD) have been observed as follows: severe disease activity in IBD correlates with severe fatigue, major psychiatr...

    Authors: Shin-Yi Tsai, Hsuan-Ju Chen, Chon-Fu Lio, Chien-Feng Kuo, An-Chun Kao, Wei-Shieng Wang, Wei-Cheng Yao, Chi Chen and Tse-Yen Yang
    Citation: Journal of Translational Medicine 2019 17:55
    Content type: Research Published on:
Submit manuscript

Follow

Annual Journal Metrics

Journal of Translational Medicine

ISSN: 1479-5876

Contact us