Clinical translation

Section edited by Lana Kandalaft

This section aims to allow rapid communication of innovative early phase clinical trials, where novel scientific ideas are translated to the clinic. These include clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside. Manuscripts are submitted typically at the time a clinical trial has gained full regulatory approval and is being initiated. No clinical results are required. These articles review the background, rationale, clinical design and approach, translational endpoints and expected outcomes of a new clinical trial in a scholarly manner, and provide the opportunity to investigators to share their views and clinical translation efforts with a wide audience at an early stage.

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  1. Methodology

    Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression

    Operational tolerance is an alternative to lifelong immunosuppression after transplantation. One strategy to achieve tolerance is by T regulatory cells. Safety and feasibility of a T regulatory type 1 (Tr1)-ce...

    Bechara Mfarrej, Eleonora Tresoldi, Angela Stabilini, Alessia Paganelli, Rossana Caldara, Antonio Secchi and Manuela Battaglia

    Journal of Translational Medicine 2017 15:40

    Published on: 21 February 2017

  2. Research

    Distinct patterns and prognostic values of tumor-infiltrating macrophages in hepatocellular carcinoma and gastric cancer

    Macrophages (Mφs) constitute a major component of the leukocyte infiltrate and perform distinct roles in different tumor microenvironments. This study aimed to characterize the distribution, composition and pr...

    Jin-Qing Li, Xing-Juan Yu, Yong-Chun Wang, Li-Yun Huang, Chao-Qun Liu, Limin Zheng, Yu-jing Fang and Jing Xu

    Journal of Translational Medicine 2017 15:37

    Published on: 15 February 2017

  3. Methodology

    Lymph node pooling: a feasible and efficient method of lymph node molecular staging in colorectal carcinoma

    Pathologic lymph node staging is becoming a deficient method in the demanding molecular era. Nevertheless, the use of more sensitive molecular analysis for nodal staging is hampered by its high costs and exte...

    Natalia Rakislova, Carla Montironi, Iban Aldecoa, Eva Fernandez, Josep Antoni Bombi, Mireya Jimeno, Francesc Balaguer, Maria Pellise, Antoni Castells and Miriam Cuatrecasas

    Journal of Translational Medicine 2017 15:14

    Published on: 14 January 2017

  4. Research

    B cell repertoires in HLA-sensitized kidney transplant candidates undergoing desensitization therapy

    Kidney transplantation is the most effective treatment for end-stage renal disease. Sensitization refers to pre-existing antibodies against human leukocyte antigen (HLA) protein and remains a major barrier to ...

    John F. Beausang, H. Christina Fan, Rene Sit, Maria U. Hutchins, Kshama Jirage, Rachael Curtis, Edward Hutchins, Stephen R. Quake and Julie M. Yabu

    Journal of Translational Medicine 2017 15:9

    Published on: 13 January 2017

  5. Methodology

    Advances in rare cell isolation: an optimization and evaluation study

    Rare nucleated CD45 negative cells in peripheral blood may be malignant such as circulating tumor cells. Untouched isolation thereof by depletion of normal is favored yet still technological challenging. We op...

    Stefan Schreier, Piamsiri Sawaisorn, Rachanee Udomsangpetch and Wannapong Triampo

    Journal of Translational Medicine 2017 15:6

    Published on: 5 January 2017

  6. Research

    Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers—results of a dose escalation trial

    Certain disadvantages of the standard hematopoietic stem and progenitor cell (HSPC) mobilizing agent G-CSF fuel the quest for alternatives. We herein report results of a Phase I dose escalation trial comparing...

    Darja Karpova, Susanne Bräuninger, Eliza Wiercinska, Ariane Krämer, Belinda Stock, Jochen Graff, Hans Martin, Achim Wach, Christophe Escot, Garry Douglas, Barbara Romagnoli, Eric Chevalier, Klaus Dembowski, Leon Hooftman and Halvard Bonig

    Journal of Translational Medicine 2017 15:2

    Published on: 3 January 2017

  7. Research

    LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2

    Mantle cell lymphoma (MCL) is considered an aggressive subtype of non-Hodgkin’s lymphoma with variable treatment responses. There is an urgent need to identify novel markers with prognostic and therapeutic val...

    Xin Wang, Lalit Sehgal, Neeraj Jain, Tamer Khashab, Rohit Mathur and Felipe Samaniego

    Journal of Translational Medicine 2016 14:346

    Published on: 20 December 2016

  8. Research

    Safety and feasibility of cell-based therapy of autologous bone marrow-derived mononuclear cells in plate-stabilized proximal humeral fractures in humans

    Local implantation of ex vivo concentrated, washed and filtrated human bone marrow-derived mononuclear cells (BMC) seeded onto β-tricalciumphosphate (TCP) significantly enhanced bone healing in a preclinical s...

    Caroline Seebach, Dirk Henrich, Simon Meier, Christoph Nau, Halvard Bonig and Ingo Marzi

    Journal of Translational Medicine 2016 14:314

    Published on: 15 November 2016

  9. Research

    Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study

    Mechanical ventilation (MV) during a cardio-thoracic surgery contributes to diaphragm muscle dysfunction that impairs weaning and can lead to the ventilator- induced diaphragm dysfunction. Especially, it is cr...

    Robert T. Mankowski, Shakeel Ahmed, Thomas Beaver, Marvin Dirain, Chul Han, Phillip Hess, Tomas Martin, Barbara K. Smith, Shinichi Someya, Christiaan Leeuwenburgh and A. Daniel Martin

    Journal of Translational Medicine 2016 14:305

    Published on: 26 October 2016

  10. Research

    Putrescine treatment reverses α-tocopherol-induced desynchronization of polyamine and retinoid metabolism during rat liver regeneration

    The pre-treatment with α-tocopherol inhibits progression of rat liver proliferation induced by partial hepatectomy (PH), by decreasing and/or desynchronizing cyclin D1 expression and activation into the nucleu...

    Lourdes Sánchez-Sevilla, Edgar Mendieta-Condado and Rolando Hernández-Muñoz

    Journal of Translational Medicine 2016 14:307

    Published on: 26 October 2016

  11. Research

    Increased urinary CD80 excretion and podocyturia in Fabry disease

    Certain glomerulopathies are associated with increased levels of CD80 (B7-1). We measured the urinary excretion of CD80, podocyturia and proteinuria in controls and in subjects with Fabry disease either untrea...

    H. Trimarchi, R. Canzonieri, A. Schiel, C. Costales-Collaguazo, J. Politei, A. Stern, M. Paulero, T. Rengel, J. Andrews, M. Forrester, M. Lombi, V. Pomeranz, R. Iriarte, A. Muryan, E. Zotta, M. D. Sanchez-Niño…

    Journal of Translational Medicine 2016 14:289

    Published on: 13 October 2016

  12. Research

    Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study

    Patients with lower extremity peripheral artery disease (PAD) have decreased mobility, which is not fully explained by impaired blood supply to the lower limb. Additionally, reports are conflicted regarding fi...

    Sarah H. White, Mary M. McDermott, Robert L. Sufit, Kate Kosmac, Alex W. Bugg, Marta Gonzalez-Freire, Luigi Ferrucci, Lu Tian, Lihui Zhao, Ying Gao, Melina R. Kibbe, Michael H. Criqui, Christiaan Leeuwenburgh and Charlotte A. Peterson

    Journal of Translational Medicine 2016 14:284

    Published on: 29 September 2016

    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:45

  13. Research

    Inhibition of complement improves graft outcome in a pig model of kidney autotransplantation

    Ischemia reperfusion injury (IRI) induced immune response is a critical issue in transplantation. Complement and contact system activation are among its key mechanisms.

    Pierre-Olivier Delpech, Raphael Thuillier, Thibault SaintYves, Jerome Danion, Sylvain Le Pape, Edwin S. van Amersfoort, Beatrijs Oortwijn, Gilles Blancho and Thierry Hauet

    Journal of Translational Medicine 2016 14:277

    Published on: 23 September 2016

  14. Commentary

    Continued importance in translation from research to health policy in China

    Precision Medicine may be considered as another strategic effort of “from-bench-to-beside” translation. In order to have a maximal impact on population health, the translation must go further. A new translatio...

    Jun Zhang, Fan Jiang and Xiaoming Shen

    Journal of Translational Medicine 2016 14:272

    Published on: 20 September 2016

  15. Research

    Celecoxib suppresses autophagy and enhances cytotoxicity of imatinib in imatinib-resistant chronic myeloid leukemia cells

    Chronic myelogenous leukemia (CML) is a hematological stem cell disorder. Tyrosine kinase inhibitors (TKIs) are the standard treatments for CML, but a number of patients fail to respond effectively due to gene...

    Ying Lu, Ling-Ling Liu, Shou-Sheng Liu, Zhi-Gang Fang, Yong Zou, Xu-Bin Deng, Zi-Jie Long, Quentin Liu and Dong-Jun Lin

    Journal of Translational Medicine 2016 14:270

    Published on: 20 September 2016

  16. Research

    Repositioning of bromocriptine for treatment of acute myeloid leukemia

    Treatment for acute myeloid leukemia (AML) has not significantly changed in the last decades and new therapeutic approaches are needed to achieve prolonged survival rates. Leukemia stem cells (LSC) are respons...

    María Carmen Lara-Castillo, Josep Maria Cornet-Masana, Amaia Etxabe, Antònia Banús-Mulet, Miguel Ángel Torrente, Meritxell Nomdedeu, Marina Díaz-Beyá, Jordi Esteve and Ruth M. Risueño

    Journal of Translational Medicine 2016 14:261

    Published on: 7 September 2016

  17. Research

    Relationship of TRIM5 and TRIM22 polymorphisms with liver disease and HCV clearance after antiviral therapy in HIV/HCV coinfected patients

    TRIM5 and TRIM22 are restriction factors involved in innate immune response and exhibit anti-viral activity. Single nucleotide polymorphisms (SNPs) at TRIM5 and TRIM22 genes have shown to influence several viral ...

    Luz M. Medrano, Norma Rallón, Juan Berenguer, María A. Jiménez-Sousa, Vicente Soriano, Teresa Aldámiz-Echevarria, Amanda Fernández-Rodríguez, Marcial García, Francisco Tejerina, Isidoro Martínez, José M. Benito and Salvador Resino

    Journal of Translational Medicine 2016 14:257

    Published on: 2 September 2016

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