Clinical translation

Section edited by Lana Kandalaft

This section aims to allow rapid communication of innovative early phase clinical trials, where novel scientific ideas are translated to the clinic. These include clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside. Manuscripts are submitted typically at the time a clinical trial has gained full regulatory approval and is being initiated. No clinical results are required. These articles review the background, rationale, clinical design and approach, translational endpoints and expected outcomes of a new clinical trial in a scholarly manner, and provide the opportunity to investigators to share their views and clinical translation efforts with a wide audience at an early stage.

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  1. Research

    Repositioning of bromocriptine for treatment of acute myeloid leukemia

    Treatment for acute myeloid leukemia (AML) has not significantly changed in the last decades and new therapeutic approaches are needed to achieve prolonged survival rates. Leukemia stem cells (LSC) are respons...

    María Carmen Lara-Castillo, Josep Maria Cornet-Masana, Amaia Etxabe, Antònia Banús-Mulet, Miguel Ángel Torrente, Meritxell Nomdedeu, Marina Díaz-Beyá, Jordi Esteve and Ruth M. Risueño

    Journal of Translational Medicine 2016 14:261

    Published on: 7 September 2016

  2. Research

    Relationship of TRIM5 and TRIM22 polymorphisms with liver disease and HCV clearance after antiviral therapy in HIV/HCV coinfected patients

    TRIM5 and TRIM22 are restriction factors involved in innate immune response and exhibit anti-viral activity. Single nucleotide polymorphisms (SNPs) at TRIM5 and TRIM22 genes have shown to influence several viral ...

    Luz M. Medrano, Norma Rallón, Juan Berenguer, María A. Jiménez-Sousa, Vicente Soriano, Teresa Aldámiz-Echevarria, Amanda Fernández-Rodríguez, Marcial García, Francisco Tejerina, Isidoro Martínez, José M. Benito and Salvador Resino

    Journal of Translational Medicine 2016 14:257

    Published on: 2 September 2016

  3. Research

    Proton-pump inhibitor omeprazole attenuates hyperoxia induced lung injury

    The administration of supplemental oxygen to treat ventilatory insufficiency may lead to the formation of reactive oxygen species and subsequent tissue damage. Cytochrome P4501A1 (CYP1A1) can modulate hyperoxi...

    Jute Richter, Julio Jimenez, Taro Nagatomo, Jaan Toelen, Paul Brady, Thomas Salaets, Flore Lesage, Jeroen Vanoirbeek and Jan Deprest

    Journal of Translational Medicine 2016 14:247

    Published on: 27 August 2016

  4. Research

    Micro-RNA-21 (biomarker) and global longitudinal strain (functional marker) in detection of myocardial fibrotic burden in severe aortic valve stenosis: a pilot study

    Myocardial fibrosis (MF) is a deleterious consequence of aortic valve stenosis (AVS). Global longitudinal strain (GLS) is a novel left ventricular (LV) functional parameter potentially useful to non-invasively...

    Iacopo Fabiani, Cristian Scatena, Chiara Maria Mazzanti, Lorenzo Conte, Nicola Riccardo Pugliese, Sara Franceschi, Francesca Lessi, Michele Menicagli, Andrea De Martino, Stefano Pratali, Uberto Bortolotti, Antonio Giuseppe Naccarato, Salvatore La Carrubba and Vitantonio Di Bello

    Journal of Translational Medicine 2016 14:248

    Published on: 27 August 2016

  5. Research

    Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II)

    Mesenchymal stromal cells are a promising option to treat knee osteoarthritis. Their safety and usefulness must be confirmed and the optimal dose established. We tested increasing doses of bone marrow mesenchy...

    José M. Lamo-Espinosa, Gonzalo Mora, Juan F. Blanco, Froilán Granero-Moltó, Jorge M. Nuñez-Córdoba, Carmen Sánchez-Echenique, José M. Bondía, Jesús Dámaso Aquerreta, Enrique J. Andreu, Enrique Ornilla, Eva M. Villarón, Andrés Valentí-Azcárate, Fermín Sánchez-Guijo, María Consuelo del Cañizo, Juan Ramón Valentí-Nin and Felipe Prósper

    Journal of Translational Medicine 2016 14:246

    Published on: 26 August 2016

  6. Research

    Phenotypic and metabolic features of mouse diaphragm and gastrocnemius muscles in chronic lung carcinogenesis: influence of underlying emphysema

    Muscle wasting negatively impacts the progress of chronic diseases such as lung cancer (LC) and emphysema, which are in turn interrelated.

    Anna Salazar-Degracia, David Blanco, Mònica Vilà-Ubach, Gabriel de Biurrun, Carlos Ortiz de Solórzano, Luis M. Montuenga and Esther Barreiro

    Journal of Translational Medicine 2016 14:244

    Published on: 23 August 2016

  7. Research

    Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients

    Ipilimumab (Ipi) improves the survival of advanced melanoma patients with an incremental long-term benefit in 10–15 % of patients. A tumor signature that correlates with this survival benefit could help optimi...

    Teofila Seremet, Alexander Koch, Yanina Jansen, Max Schreuer, Sofie Wilgenhof, Véronique Del Marmol, Danielle Liènard, Kris Thielemans, Kelly Schats, Mark Kockx, Wim Van Criekinge, Pierre G. Coulie, Tim De Meyer, Nicolas van Baren and Bart Neyns

    Journal of Translational Medicine 2016 14:232

    Published on: 2 August 2016

  8. Research

    Definition by FSH, AMH and embryo numbers of good-, intermediate- and poor-prognosis patients suggests previously unknown IVF outcome-determining factor associated with AMH

    Though outcome models have been proposed previously, it is unknown whether cutoffs in clinical pregnancy and live birth rates at all ages are able to classify in vitro fertilization (IVF) patients into good-, ...

    Norbert Gleicher, Vitaly A. Kushnir, Aritro Sen, Sarah K. Darmon, Andrea Weghofer, Yan-Guang Wu, Qi Wang, Lin Zhang, David F. Albertini and David H. Barad

    Journal of Translational Medicine 2016 14:172

    Published on: 10 June 2016

  9. Research

    Ultrastructural regenerating features of nasal mucosa following microdebrider-assisted turbinoplasty are related to clinical recovery

    The nasal mucosa plays a key role in conditioning the inhaled air and in regulating the immune response. These functions led many authors to recommend mucosal sparing techniques for the surgical management of...

    Giampiero Neri, Fiorella Cazzato, Valentina Mastronardi, Mara Pugliese, Maria Antonietta Centurione, Roberta Di Pietro and Lucia Centurione

    Journal of Translational Medicine 2016 14:164

    Published on: 8 June 2016

  10. Research

    Centrosome associated genes pattern for risk sub-stratification in multiple myeloma

    The genome of multiple myeloma (MM) cells is extremely unstable, characterized by a complex combination of structure and numerical abnormalities. It seems that there are several “myeloma subgroups” which diffe...

    Fedor Kryukov, Pavel Nemec, Lenka Radova, Elena Kryukova, Samuel Okubote, Jiri Minarik, Zdena Stefanikova, Ludek Pour and Roman Hajek

    Journal of Translational Medicine 2016 14:150

    Published on: 28 May 2016

  11. Research

    Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV

    Many HIV infected individuals with suppressed viral loads experience chronic immune activation frequently developing neurological impairment designated as HIV associated neurocognitive disorder (HAND). Adjunct...

    Jeffrey S. Barrett, Sergei Spitsin, Ganesh Moorthy, Kyle Barrett, Kate Baker, Andrew Lackner, Florin Tulic, Angela Winters, Dwight L. Evans and Steven D. Douglas

    Journal of Translational Medicine 2016 14:148

    Published on: 26 May 2016

  12. Research

    Altered neuroendocrine control and association to clinical symptoms in adolescent chronic fatigue syndrome: a cross-sectional study

    Chronic fatigue syndrome (CFS) is a common and disabling disorder, and a major threat against adolescent health. The pathophysiology is unknown, but alteration of neuroendocrine control systems might be a cent...

    Vegard Bruun Wyller, Valieria Vitelli, Dag Sulheim, Even Fagermoen, Anette Winger, Kristin Godang and Jens Bollerslev

    Journal of Translational Medicine 2016 14:121

    Published on: 5 May 2016

  13. Research

    Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer

    SCLC has limited treatment options and inadequate preclinical models. Promising activity of arsenic trioxide (ASO) recorded in conventional preclinical models of SCLC supported the clinical evaluation of ASO i...

    Taofeek K. Owonikoko, Guojing Zhang, Hyun S. Kim, Renea M. Stinson, Rabih Bechara, Chao Zhang, Zhengjia Chen, Nabil F. Saba, Suchita Pakkala, Rathi Pillai, Xingming Deng, Shi-Yong Sun, Michael R. Rossi, Gabriel L. Sica, Suresh S. Ramalingam and Fadlo R. Khuri

    Journal of Translational Medicine 2016 14:111

    Published on: 3 May 2016

  14. Research

    Calprotectin could be a potential biomarker for acute appendicitis

    Acute appendicitis is a common cause for a visit to the emergency department and appendectomy represents the most common emergency procedure in surgery. The rate of negative appendectomy however has remained h...

    Peter C. Ambe, Daniel Gödde, Lars Bönicke, Marios Papadakis, Stephan Störkel and Hubert Zirngibl

    Journal of Translational Medicine 2016 14:107

    Published on: 27 April 2016

  15. Protocol

    Rationale and design of the DP-TRANSFERS project: diabetes prevention-transferring findings from European research to society in Catalonia

    Compelling evidence has been accumulated to support the effectiveness of intensive lifestyle intervention in delaying progression to Type 2 diabetes even in people identified as being at high risk determined b...

    Bernardo Costa, Conxa Castell, Xavier Cos, Claustre Solé, Santiago Mestre, Marta Canela, Antoni Boquet, Joan-Josep Cabré, Francisco Barrio, Gemma Flores-Mateo, Daniel Ferrer-Vidal and Jaana Lindström

    Journal of Translational Medicine 2016 14:103

    Published on: 27 April 2016

  16. Research

    Quantitative assessment of BRAF V600 mutant circulating cell-free tumor DNA as a tool for therapeutic monitoring in metastatic melanoma patients treated with BRAF/MEK inhibitors

    BRAF V600 mutant circulating cell-free tumor DNA (BRAF V600mut ctDNA) could serve as a specific biomarker in patients with BRAF V600 mutant melanoma. We analyzed the value of BRAF V600...

    Max Schreuer, Geert Meersseman, Sari Van Den Herrewegen, Yanina Jansen, Ines Chevolet, Ambre Bott, Sofie Wilgenhof, Teofila Seremet, Bart Jacobs, Ronald Buyl, Geert Maertens and Bart Neyns

    Journal of Translational Medicine 2016 14:95

    Published on: 19 April 2016

  17. Research

    Characterization of viscosupplementation formulations using chemical exchange saturation transfer (ViscoCEST)

    Osteoarthritis (OA) is characterized by progressive loss of cartilage in joints, and is a major cause of pain and disability, and imposes significant health care expense. New therapies are being developed to t...

    Mohammad Haris, Anup Singh, Sanjana Reddy, Puneet Bagga, J. Bruce Kneeland, Fotios P. Tjoumakaris, Hari Hariharan, Francesco M. Marincola and Ravinder Reddy

    Journal of Translational Medicine 2016 14:92

    Published on: 12 April 2016

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