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Table 4 Distribution of autoantibodies among autoantibody clusters

From: Cytokine and autoantibody clusters interaction in systemic lupus erythematosus

Autoantibody

Neutral (n = 38)

APLA-dominant (n = 13)

dsDNA/ENA-dominant (n = 16)

p-value

ANAs

31 (82)

10 (77)

16 (100)

0.145

RF

12 (32)

5 (38)

7 (44)

0.678

CCP3

1 (3)

0 (0)

0 (0)

0.678

TPOAb

4 (10)

3 (23)

0 (0)

0.129

TgAb

3 (8)

2 (15)

0 (0)

0.289

dsDNA

9 (24)

9 (69)

14 (87)

< 0.0001*

ACA-IgM

4 (10)

7 (54)

0 (0)

0.0002*

ACA-IgG

0 (0)

11 (85)

1 (6)

< 0.0001*

β2GP1-IgM

2 (5)

4 (31)

1 (6)

0.028

β2GP1-IgG

0 (0)

6 (46)

0 (0)

< 0.0001*

RNP

3 (8)

8 (61)

14 (87)

< 0.0001*

Ro

13 (34)

5 (38)

8 (50)

0.553

La

1 (3)

0 (0)

4 (25)

0.008

Sm

0 (0)

1 (8)

11 (69)

< 0.0001*

  1. Data correspond to number of patients (%)
  2. ANAs antinuclear antibodies, RF rheumatoid factor, CCP3 anti-cyclic citrullinated peptide third-generation, TPOAb anti-thyroperoxidase antibody, TgAb anti-thyroglobulin antibody, dsDNA anti-double stranded DNA antibodies, ACA anticardiolipin antibody, β2GP1 β2 glycoprotein-1
  3. * Statistically significant after Bonferroni correction