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Table 5 Distribution of cytokines among cytokine clusters

From: Cytokine and autoantibody clusters interaction in systemic lupus erythematosus

Cytokine Neutral (n = 24) Chemotactic (n = 13) G-CSF (n = 20) IFNα/Pro-inflammatory (n = 10) p-value
IL-2 1 (4) 0 (0) 0 (0) 1 (10) 0.418
IL-4 0 (0) 0 (0) 1 (5) 3 (30) 0.005
IL-5 1 (4) 0 (0) 1 (5) 4 (40) 0.002*
IL-6 0 (0) 4 (31) 8 (40) 3 (30) 0.009
IL-9 1 (4) 0 (0) 0 (0) 1 (10) 0.418
IL-10 1 (4) 2 (15) 4 (20) 7 (70) 0.0003*
IL-17A 3 (12) 0 (0) 0 (0) 8 (80) < 0.0001*
TNFα 0 (0) 0 (0) 0 (0) 9 (90) < 0.0001*
G-CSF 0 (0) 4 (31) 19 (95) 8 (80) < 0.0001*
IFNα 2 (8) 1 (8) 4 (20) 10 (100) < 0.0001*
IFNγ 0 (0) 1 (8) 1 (5) 2 (20) 0.162
IL-13 0 (0) 0 (0) 0 (0) 1 (10) 0.122
IL-1β 0 (0) 1 (8) 0 (0) 5 (50) < 0.0001*
IL-8 0 (0) 13 (100) 0 (0) 3 (30) < 0.0001*
IL-12/23p40 6 (25) 4 (31) 15 (75) 10 (100) < 0.0001*
  1. Data correspond to number of positive patients (%)
  2. IL interleukin, G-CSF granulocyte colony-stimulating factor, IFN interferon, TNF tumor necrosis factor
  3. * Statistically significant after Bonferroni correction