Cytokine and autoantibody clusters interaction in systemic lupus erythematosus

Table 5 Distribution of cytokines among cytokine clusters

Cytokine	Neutral (n = 24)	Chemotactic (n = 13)	G-CSF (n = 20)	IFNα/Pro-inflammatory (n = 10)	p-value
IL-2	1 (4)	0 (0)	0 (0)	1 (10)	0.418
IL-4	0 (0)	0 (0)	1 (5)	3 (30)	0.005
IL-5	1 (4)	0 (0)	1 (5)	4 (40)	0.002*
IL-6	0 (0)	4 (31)	8 (40)	3 (30)	0.009
IL-9	1 (4)	0 (0)	0 (0)	1 (10)	0.418
IL-10	1 (4)	2 (15)	4 (20)	7 (70)	0.0003*
IL-17A	3 (12)	0 (0)	0 (0)	8 (80)	< 0.0001*
TNFα	0 (0)	0 (0)	0 (0)	9 (90)	< 0.0001*
G-CSF	0 (0)	4 (31)	19 (95)	8 (80)	< 0.0001*
IFNα	2 (8)	1 (8)	4 (20)	10 (100)	< 0.0001*
IFNγ	0 (0)	1 (8)	1 (5)	2 (20)	0.162
IL-13	0 (0)	0 (0)	0 (0)	1 (10)	0.122
IL-1β	0 (0)	1 (8)	0 (0)	5 (50)	< 0.0001*
IL-8	0 (0)	13 (100)	0 (0)	3 (30)	< 0.0001*
IL-12/23p40	6 (25)	4 (31)	15 (75)	10 (100)	< 0.0001*

Data correspond to number of positive patients (%)
IL interleukin, G-CSF granulocyte colony-stimulating factor, IFN interferon, TNF tumor necrosis factor
* Statistically significant after Bonferroni correction

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