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Table 2 Tumor expression of markers belonging to PI3K/Akt signaling pathway and their prognostic impact on disease-specific survival in patients with non-GIST STSs (univariate analyses; log-rank test, n = 249), for all patients and separately for men and women.

From: The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas

Marker expression

Patients, n (%)

Median survival

(months)

5-Year survival (%)

P

 

A

M

W

A

M

W

A

M

W

A

M

W

p-Akt Thr 308

            

Low

131(53)

59 (55)

72 (52)

91

NR

80

55

56

54

0.002

0.009

0.064

High

113 (45)

48 (44)

65 (47)

29

26

31

35

33

36

   

Missing

5 (2)

3 (1)

2 (1)

         

p-Akt Ser 473

            

Low

70 (28)

35 (32)

35 (25)

62

41

127

51

45

57

0.074

0.868

0.023

High

174 (70)

74 (67)

100 (72)

31

41

29

43

46

40

   

Missing

5 (2)

1 (1)

4 (3)

         

Akt2

            

Low

82 (33)

41 (37)

41 (39)

123

NR

80

58

56

59

0.008

0.062

0.064

High

163 (65)

68 (62)

95 (68)

31

31

31

41

42

40

   

Missing

4 (2)

1 (1)

3 (3)

         

Akt3

            

Low

177 (71)

81 (74)

96 (69)

62

63

57

51

51

50

0.067

0.207

0.197

High

60 (24)

22 (20)

38 (27)

31

27

38

35

33

36

   

Missing

12 (5)

7 (6)

5 (4)

         

PI3K

            

Negative

104 (42)

44 (40)

60 (43)

NR

NR

127

60

57

63

<0.001

0.078

<0.001

Positive

136 (56)

61 (55)

75 (54)

29

37

23

37

41

33

   

Missing

9 (4)

5 (5)

4 (3)

         

PTEN

            

Negative

88 (35)

37 (34)

51 (37)

80

NR

80

51

51

51

0.259

0.658

0.198

Positive

148 (59)

67 (61)

81 (58)

41

41

38

46

48

44

   

Missing

13 (6)

5 (5)

7 (5)

         
  1. Abbreviations: Non-GIST STS, non-gastro intestinal stromal tumor soft-tissue sarcoma; A, all; M, men; W, women; NR, not reached