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Table 2 Tumor expression of markers belonging to PI3K/Akt signaling pathway and their prognostic impact on disease-specific survival in patients with non-GIST STSs (univariate analyses; log-rank test, n = 249), for all patients and separately for men and women.

From: The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas

Marker expression Patients, n (%) Median survival (months) 5-Year survival (%) P
  A M W A M W A M W A M W
p-Akt Thr 308             
Low 131(53) 59 (55) 72 (52) 91 NR 80 55 56 54 0.002 0.009 0.064
High 113 (45) 48 (44) 65 (47) 29 26 31 35 33 36    
Missing 5 (2) 3 (1) 2 (1)          
p-Akt Ser 473             
Low 70 (28) 35 (32) 35 (25) 62 41 127 51 45 57 0.074 0.868 0.023
High 174 (70) 74 (67) 100 (72) 31 41 29 43 46 40    
Missing 5 (2) 1 (1) 4 (3)          
Akt2             
Low 82 (33) 41 (37) 41 (39) 123 NR 80 58 56 59 0.008 0.062 0.064
High 163 (65) 68 (62) 95 (68) 31 31 31 41 42 40    
Missing 4 (2) 1 (1) 3 (3)          
Akt3             
Low 177 (71) 81 (74) 96 (69) 62 63 57 51 51 50 0.067 0.207 0.197
High 60 (24) 22 (20) 38 (27) 31 27 38 35 33 36    
Missing 12 (5) 7 (6) 5 (4)          
PI3K             
Negative 104 (42) 44 (40) 60 (43) NR NR 127 60 57 63 <0.001 0.078 <0.001
Positive 136 (56) 61 (55) 75 (54) 29 37 23 37 41 33    
Missing 9 (4) 5 (5) 4 (3)          
PTEN             
Negative 88 (35) 37 (34) 51 (37) 80 NR 80 51 51 51 0.259 0.658 0.198
Positive 148 (59) 67 (61) 81 (58) 41 41 38 46 48 44    
Missing 13 (6) 5 (5) 7 (5)          
  1. Abbreviations: Non-GIST STS, non-gastro intestinal stromal tumor soft-tissue sarcoma; A, all; M, men; W, women; NR, not reached