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Table 4 Co-expression of activated AKT and PI3K with ER and PGR and their prediction for DSS in patients with non-GIST STSs (univariate analyses; log-rank test, n = 249, only significant combinations are represented) and results of Cox regression analysis (multivariate analyses).

From: The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas

Univariate analyses Multivariate analyses
Markers coexpression Patients (n) Patients (%) Median survival (months) 5-Year survival (%) P Hazard ratio 95% CI P
ER/p-Akt Thr 308 all    
-/- 83 33 127 57 0.002    NS
-/+ 58 23 18 29     
+/- 42 17 63 54     
+/+ 47 19 45 46     
Missing 19 8       
ER/p-Akt Thr 308 women    
-/- 42 30 57 50 0.012    NS
-/+ 35 25 16 27     
+/- 27 19 91 59     
+/+ 25 19 120 53     
Missing 11 7       
PgR/p-Akt Thr 308 all    
-/- 101 41 127 59 0.014    NS
-/+ 62 25 26 38     
+/- 26 10 54 46     
+/+ 49 20 32 32     
Missing 11 4       
PgR/p-Akt Thr 308 men    
-/- 49 45 NR 64 0.003 1.0   0.099*
-/+ 30 27 29 43   2.0 1.0-4.1 0.047
+/- 8 7 15 25   1.8 0.65-4.8 0.261
+/+ 17 16 17 18   2.4 1.1-5.2 0.023
Missing 6 5       
ER/p-Akt Ser 473 women    
-/- 18 13 127 63 0.006    NS
-/+ 58 41 16 32     
+/- 14 10 62 56     
+/+ 37 27 91 55     
Missing 13 9       
PgR/p-Akt Ser 473 men    
-/- 29 27 NR 55 0.010 1.0   0.022*
-/+ 51 47 NR 57   1.1 0.54-2.4 0.744
+/- 4 4 21 0   6.7 1.9-24 0.003
+/+ 21 19 15 24   1.5 0.67-3.2 0.329
Missing 5 5       
ER/PI3K all    
-/- 65 27 127 60 0.002 1.0   0.032*
-/+ 73 29 18 36   2.0 1.2-3.2 0.005
+/- 33 13 NR 63   1.1 0.56-2.1 0.816
+/+ 56 22 37 43   1.4 0.83-2.4 0.200
Missing 22 9       
ER/PI3K women    
-/- 33 24 100 59 <0.001 1.0   0.036*
-/+ 42 30 15 25   2.4 1.2-4.8 0.014
+/- 23 16 NR 70   0.9 0.36-2.0 0.715
+/+ 29 21 29 46   1.5 0.72-3.0 0.290
Missing 13 9       
PgR/PI3K all    
-/- 76 31 NR 62 0.001 1.0   0.032*
-/+ 86 35 29 43   1.9 1.2-3.0 0.007
+/- 26 10 100 58   1.3 0.69-2.5 0.397
+/+ 46 18 31 27   1.9 1.1-3.2 0.014
Missing 15 6       
PgR/PI3K men    
-/- 36 34 NR 65 0.014    NS
-/+ 44 40 63 51     
+/- 7 6 21 29     
+/+ 15 14 17 20     
Missing 7 6       
PgR/PI3K women    
-/- 40 29 80 59 0.007    NS
-/+ 42 30 17 36     
+/- 19 14 NR 68     
+/+ 31 21 31 31     
Missing 8 6       
  1. Abbreviations: ER, estrogen receptor; PgR, progesterone receptor; NR, not reached; NS, not significant;
  2. * overall significance as a prognostic factor