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Table 4 Co-expression of activated AKT and PI3K with ER and PGR and their prediction for DSS in patients with non-GIST STSs (univariate analyses; log-rank test, n = 249, only significant combinations are represented) and results of Cox regression analysis (multivariate analyses).

From: The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas

Univariate analyses

Multivariate analyses

Markers

coexpression

Patients

(n)

Patients

(%)

Median survival

(months)

5-Year survival

(%)

P

Hazard ratio

95% CI

P

ER/p-Akt Thr 308 all

   

-/-

83

33

127

57

0.002

  

NS

-/+

58

23

18

29

    

+/-

42

17

63

54

    

+/+

47

19

45

46

    

Missing

19

8

      

ER/p-Akt Thr 308 women

   

-/-

42

30

57

50

0.012

  

NS

-/+

35

25

16

27

    

+/-

27

19

91

59

    

+/+

25

19

120

53

    

Missing

11

7

      

PgR/p-Akt Thr 308 all

   

-/-

101

41

127

59

0.014

  

NS

-/+

62

25

26

38

    

+/-

26

10

54

46

    

+/+

49

20

32

32

    

Missing

11

4

      

PgR/p-Akt Thr 308 men

   

-/-

49

45

NR

64

0.003

1.0

 

0.099*

-/+

30

27

29

43

 

2.0

1.0-4.1

0.047

+/-

8

7

15

25

 

1.8

0.65-4.8

0.261

+/+

17

16

17

18

 

2.4

1.1-5.2

0.023

Missing

6

5

      

ER/p-Akt Ser 473 women

   

-/-

18

13

127

63

0.006

  

NS

-/+

58

41

16

32

    

+/-

14

10

62

56

    

+/+

37

27

91

55

    

Missing

13

9

      

PgR/p-Akt Ser 473 men

   

-/-

29

27

NR

55

0.010

1.0

 

0.022*

-/+

51

47

NR

57

 

1.1

0.54-2.4

0.744

+/-

4

4

21

0

 

6.7

1.9-24

0.003

+/+

21

19

15

24

 

1.5

0.67-3.2

0.329

Missing

5

5

      

ER/PI3K all

   

-/-

65

27

127

60

0.002

1.0

 

0.032*

-/+

73

29

18

36

 

2.0

1.2-3.2

0.005

+/-

33

13

NR

63

 

1.1

0.56-2.1

0.816

+/+

56

22

37

43

 

1.4

0.83-2.4

0.200

Missing

22

9

      

ER/PI3K women

   

-/-

33

24

100

59

<0.001

1.0

 

0.036*

-/+

42

30

15

25

 

2.4

1.2-4.8

0.014

+/-

23

16

NR

70

 

0.9

0.36-2.0

0.715

+/+

29

21

29

46

 

1.5

0.72-3.0

0.290

Missing

13

9

      

PgR/PI3K all

   

-/-

76

31

NR

62

0.001

1.0

 

0.032*

-/+

86

35

29

43

 

1.9

1.2-3.0

0.007

+/-

26

10

100

58

 

1.3

0.69-2.5

0.397

+/+

46

18

31

27

 

1.9

1.1-3.2

0.014

Missing

15

6

      

PgR/PI3K men

   

-/-

36

34

NR

65

0.014

  

NS

-/+

44

40

63

51

    

+/-

7

6

21

29

    

+/+

15

14

17

20

    

Missing

7

6

      

PgR/PI3K women

   

-/-

40

29

80

59

0.007

  

NS

-/+

42

30

17

36

    

+/-

19

14

NR

68

    

+/+

31

21

31

31

    

Missing

8

6

      
  1. Abbreviations: ER, estrogen receptor; PgR, progesterone receptor; NR, not reached; NS, not significant;
  2. * overall significance as a prognostic factor
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Journal of Translational Medicine

ISSN: 1479-5876

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