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  1. To test the carcinostatic effects of ascorbic acid, we challenged the mice of seven experimental groups with 1.7 × 10-4 mol high dose concentration ascorbic acid after intraperitoneal administrating them with sar...

    Authors: Chang-Hwan Yeom, Gunsup Lee, Jin-Hee Park, Jaelim Yu, Seyeon Park, Sang-Yeop Yi, Hye Ree Lee, Young Seon Hong, Joosung Yang and Sukchan Lee
    Citation: Journal of Translational Medicine 2009 7:70
  2. Ovarian cancer ascites fluid (OCAF), contains malignant cells, is usually present in women with an advanced stage disease and currently has no effective therapy. Hence, we developed a new therapy strategy to t...

    Authors: Aya Mizrahi, Abraham Czerniak, Tally Levy, Smadar Amiur, Jennifer Gallula, Imad Matouk, Rasha Abu-lail, Vladimir Sorin, Tatiana Birman, Nathan de Groot, Abraham Hochberg and Patricia Ohana
    Citation: Journal of Translational Medicine 2009 7:69
  3. To explore the biological activity of EMD 273063 (hu14.18-IL2), a humanized anti-GD2 monoclonal antibody fused to interleukin-2 (IL2), in patients with unresectable, stage IV cutaneous melanoma as measured by ...

    Authors: Antoni Ribas, John M Kirkwood, Michael B Atkins, Theresa L Whiteside, William Gooding, Andreas Kovar, Stephen D Gillies, Oscar Kashala and Michael A Morse
    Citation: Journal of Translational Medicine 2009 7:68
  4. Inotropes are associated with adverse outcomes in heart failure (HF), raising concern they may accelerate myocardial injury. Whether biomarkers of myocardial necrosis, inflammation and apoptosis change in resp...

    Authors: David E Lanfear, Reema Hasan, Ramesh C Gupta, Celeste Williams, Barbara Czerska, Cristina Tita, Rasha Bazari and Hani N Sabbah
    Citation: Journal of Translational Medicine 2009 7:67
  5. The development of cell-based therapeutics for humans requires preclinical testing in animal models. The use of autologous animal products fails to address the efficacy of similar products derived from humans....

    Authors: Thomas J Kiernan, Barry A Boilson, Tyra A Witt, Allan B Dietz, Amir Lerman and Robert D Simari
    Citation: Journal of Translational Medicine 2009 7:66
  6. mRNA profiling has become an important tool for developing and validating prognostic assays predictive of disease treatment response and outcome. Archives of annotated formalin-fixed paraffin-embedded tissues ...

    Authors: Sven Duenwald, Mingjie Zhou, Yanqun Wang, Serguei Lejnine, Amit Kulkarni, Jaime Graves, Ryan Smith, John Castle, George Tokiwa, Bernard Fine, Hongyue Dai, Thomas Fare and Matthew Marton
    Citation: Journal of Translational Medicine 2009 7:65
  7. Mycophenolic acid (MPA) is widely used as part of immunosuppressive regimens following allograft transplantation. The large pharmacokinetic (PK) and pharmacodynamic (PD) variability and narrow therapeutic rang...

    Authors: Sara Bremer, Nils T Vethe, Helge Rootwelt, Pål F Jørgensen, Jean Stenstrøm, Hallvard Holdaas, Karsten Midtvedt and Stein Bergan
    Citation: Journal of Translational Medicine 2009 7:64
  8. We previously described a sub-population of epithelial ovarian cancer (EOC) cells with a functional TLR-4/MyD88/NF-κB pathway (Type I EOC cells), which confers the capacity to respond to Paclitaxel, a known TL...

    Authors: Ki Hyung Kim, Yanhua Xie, Ewan M Tytler, Richard Woessner, Gil Mor and Ayesha B Alvero
    Citation: Journal of Translational Medicine 2009 7:63
  9. While all anti-diabetic agents can decrease blood glucose level directly or indirectly, few are able to protect and preserve both pancreatic beta cell mass and their insulin-secreting functions. Thus, there is...

    Authors: Zaijun Zhang, Jie Jiang, Pei Yu, Xiangping Zeng, James W Larrick and Yuqiang Wang
    Citation: Journal of Translational Medicine 2009 7:62
  10. Sperm protein 17 (Sp17) is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine ...

    Authors: Maurizio Chiriva-Internati, Nicoletta Gagliano, Elena Donetti, Francesco Costa, Fabio Grizzi, Barbara Franceschini, Elena Albani, Paolo E Levi-Setti, Magda Gioia, Marjorie Jenkins, Everardo Cobos and W Martin Kast
    Citation: Journal of Translational Medicine 2009 7:61
  11. Mass spectrometric analysis of the blood proteome is an emerging method of clinical proteomics. The approach exploiting multi-protein/peptide sets (fingerprints) detected by mass spectrometry that reflect over...

    Authors: Monika Pietrowska, Lukasz Marczak, Joanna Polanska, Katarzyna Behrendt, Elzbieta Nowicka, Anna Walaszczyk, Aleksandra Chmura, Regina Deja, Maciej Stobiecki, Andrzej Polanski, Rafal Tarnawski and Piotr Widlak
    Citation: Journal of Translational Medicine 2009 7:60
  12. MHC class I expression by cancer cells enables specific antigen recognition by the immune system and protection of the host. However, in some cancer types MHC class I expression is associated with an unfavorab...

    Authors: Courtney Smith, Mariarita Santi, Bhargavi Rajan, Elisabeth J Rushing, Mi Rim Choi, Brian R Rood, Robert Cornelison, Tobey J MacDonald and Stanislav Vukmanovic
    Citation: Journal of Translational Medicine 2009 7:59
  13. The dose-delivery schedule of conventional chemotherapy, which determines its efficacy and toxicity, is based on the maximum tolerated dose. This strategy has lead to cure and disease control in a significant ...

    Authors: Ramon Kaneno, Galina V Shurin, Irina L Tourkova and Michael R Shurin
    Citation: Journal of Translational Medicine 2009 7:58
  14. Cancer stem cell model suggested that tumor progression is driven by the overpopulation of cancer stem cells and eradicating or inhibiting the symmetric division of cancer stem cells would become the most impo...

    Authors: Chun-Yan Li, Bao-Xiu Li, Yi Liang, Rui-Qing Peng, Ya Ding, Da-Zhi Xu, Xin Zhang, Zhi-Zhong Pan, De-Sen Wan, Yi-Xin Zeng, Xiao-Feng Zhu and Xiao-Shi Zhang
    Citation: Journal of Translational Medicine 2009 7:56
  15. As gene expression signatures may serve as biomarkers, there is a need to develop technologies based on mRNA expression patterns that are adaptable for translational research. Xceed Molecular has recently deve...

    Authors: Michael CJ Quinn, Daniel J Wilson, Fiona Young, Adam A Dempsey, Suzanna L Arcand, Ashley H Birch, Paulina M Wojnarowicz, Diane Provencher, Anne-Marie Mes-Masson, David Englert and Patricia N Tonin
    Citation: Journal of Translational Medicine 2009 7:55
  16. New strategies for the treatment of Parkinson's disease (PD) are shifted from dopamine (DA) replacement to regeneration or restoration of the nigro-striatal system. A cell therapy using human retinal pigment e...

    Authors: Ming Ming, Xuping Li, Xiaolan Fan, Dehua Yang, Liang Li, Sheng Chen, Qing Gu and Weidong Le
    Citation: Journal of Translational Medicine 2009 7:53
  17. Diabetes is well known risk factor for thrombotic events. The association between diabetes and venous thromboembolism is still matter of debate. However, during diabetes an acquired thrombophilia is present an...

    Authors: Corrado Lodigiani, Paola Ferrazzi, Pierpaolo Di Micco, Luca Librè, Stefano Genovese, Ilaria Quaglia and Lidia Luciana Rota
    Citation: Journal of Translational Medicine 2009 7:52
  18. The existence of large pores in the blood-tumor barrier (BTB) of malignant solid tumor microvasculature makes the blood-tumor barrier more permeable to macromolecules than the endothelial barrier of most norma...

    Authors: Hemant Sarin, Ariel S Kanevsky, Haitao Wu, Alioscka A Sousa, Colin M Wilson, Maria A Aronova, Gary L Griffiths, Richard D Leapman and Howard Q Vo
    Citation: Journal of Translational Medicine 2009 7:51
  19. Membrane-bound heat shock protein 70 (Hsp70) serves as a tumor-specific recognition structure for Hsp70-peptide (TKD) plus IL-2 activated NK cells. A phase I clinical trial has shown that repeated re-infusions...

    Authors: Valeria Milani, Stefan Stangl, Rolf Issels, Mathias Gehrmann, Beate Wagner, Kathrin Hube, Doris Mayr, Wolfgang Hiddemann, Michael Molls and Gabriele Multhoff
    Citation: Journal of Translational Medicine 2009 7:50
  20. Murine studies suggest that myeloid cells such as vascular leukocytes (VLC) and Tie2+ monocytes play a critical role in tumor angiogenesis and vasculogenesis. Myeloid cells are a primary cause of resistance to an...

    Authors: Heather L Pulaski, Gregory Spahlinger, Ines A Silva, Karen McLean, Angela S Kueck, R Kevin Reynolds, George Coukos, Jose R Conejo-Garcia and Ronald J Buckanovich
    Citation: Journal of Translational Medicine 2009 7:49
  21. BPA (bisphenol A or 2,2-bis(4-hydroxy-phenol)propane) is present in the manufacture of polycarbonate plastic and epoxy resins, which can be used in impact-resistant safety equipment and baby bottles, as protec...

    Authors: Paola Bontempo, Luigi Mita, Antonella Doto, Marco Miceli, Angela Nebbioso, Ilaria Lepore, GianLuigi Franci, Roberta Menafra, Vincenzo Carafa, Mariarosaria Conte, Floriana De Bellis, Fabio Manzo, Vincenzo Di Cerbo, Rosaria Benedetti, Loredana D'Amato, Maria Marino…
    Citation: Journal of Translational Medicine 2009 7:48
  22. The protease-activated receptor (PAR1) expression is correlated with the degree of invasiveness in cell lines. Nevertheless it has never been directed involved in breast cancer patients progression. The aim of...

    Authors: Norma A Hernández, Elma Correa, Esther P Avila, Teresa A Vela and Víctor M Pérez
    Citation: Journal of Translational Medicine 2009 7:47
  23. The possibility of using stem cells for regenerative medicine has opened a new field of investigation. The search for sources to obtain multipotent stem cells from discarded tissues or through non-invasive pro...

    Authors: Tatiana Jazedje, Paulo M Perin, Carlos E Czeresnia, Mariangela Maluf, Silvio Halpern, Mariane Secco, Daniela F Bueno, Natassia M Vieira, Eder Zucconi and Mayana Zatz
    Citation: Journal of Translational Medicine 2009 7:46
  24. Supported by the Office of International Affairs, National Cancer Institute (NCI), the "US-Japan Workshop on Immunological Biomarkers in Oncology" was held in March 2009. The workshop was related to a task force ...

    Authors: Hideaki Tahara, Marimo Sato, Magdalena Thurin, Ena Wang, Lisa H Butterfield, Mary L Disis, Bernard A Fox, Peter P Lee, Samir N Khleif, Jon M Wigginton, Stefan Ambs, Yasunori Akutsu, Damien Chaussabel, Yuichiro Doki, Oleg Eremin, Wolf Hervé Fridman…
    Citation: Journal of Translational Medicine 2009 7:45
  25. To develop peptide-based immunotherapy for osteosarcoma, we previously identified papillomavirus binding factor (PBF) as a CTL-defined osteosarcoma antigen in the context of HLA-B55. However, clinical applicat...

    Authors: Tomohide Tsukahara, Satoshi Kawaguchi, Toshihiko Torigoe, Akari Takahashi, Masaki Murase, Masanobu Kano, Takuro Wada, Mitsunori Kaya, Satoshi Nagoya, Toshihiko Yamashita and Noriyuki Sato
    Citation: Journal of Translational Medicine 2009 7:44
  26. Pancreatic cancer retains a poor prognosis among the gastrointestinal cancers. It affects 230,000 individuals worldwide, has a very high mortality rate, and remains one of the most challenging malignancies to ...

    Authors: David O Azorsa, Irma M Gonzales, Gargi D Basu, Ashish Choudhary, Shilpi Arora, Kristen M Bisanz, Jeffrey A Kiefer, Meredith C Henderson, Jeffrey M Trent, Daniel D Von Hoff and Spyro Mousses
    Citation: Journal of Translational Medicine 2009 7:43
  27. Despite the use of anti-platelet agents such as acetylsalicylic acid (ASA) and clopidogrel in coronary heart disease, some patients continue to suffer from atherothrombosis. This has stimulated development of ...

    Authors: Andreas C Eriksson, Lena Jonasson, Tomas L Lindahl, Bo Hedbäck and Per A Whiss
    Citation: Journal of Translational Medicine 2009 7:42
  28. The main regulator of neovascularization is Vascular Endothelial Growth Factor (VEGF). We recently demonstrated that QK, a de novo engineered VEGF mimicking peptide, shares in vitro the same biological properties...

    Authors: Gaetano Santulli, Michele Ciccarelli, Gianluigi Palumbo, Alfonso Campanile, Gennaro Galasso, Barbara Ziaco, Giovanna Giuseppina Altobelli, Vincenzo Cimini, Federico Piscione, Luca Domenico D'Andrea, Carlo Pedone, Bruno Trimarco and Guido Iaccarino
    Citation: Journal of Translational Medicine 2009 7:41
  29. Fibroblasts are actually considered pivotal in inflammation and tissue remodelling process and for these reasons they are involved in the pathogenesis of autoimmune disorders such as celiac disease. Investigat...

    Authors: Leda Roncoroni, Luca Elli, Luisa Doneda, Luca Piodi, Michele M Ciulla, Roberta Paliotti and Maria Teresa Bardella
    Citation: Journal of Translational Medicine 2009 7:40
  30. Since the V617F mutation in JAK2 may not be the initiating event in myeloprofilerative disorders (MPDs) we compared molecular changes in neutrophils from patients with polycythemia vera (PV) and essential thro...

    Authors: Stefanie Slezak, Ping Jin, Lorraine Caruccio, Jiaqiang Ren, Michael Bennett, Nausheen Zia, Sharon Adams, Ena Wang, Joao Ascensao, Geraldine Schechter and David Stroncek
    Citation: Journal of Translational Medicine 2009 7:39
  31. High mobility group box-1 (HMGB1) is a newly recognized factor regulating cancer cell tumorigenesis, expansion and invasion. We investigated the correlation between the serum HMGB1 levels and the clinical and ...

    Authors: Hye Won Chung, Sang-Guk Lee, Heejung Kim, Duck Jin Hong, Jae Bock Chung, David Stroncek and Jong-Baeck Lim
    Citation: Journal of Translational Medicine 2009 7:38
  32. Endocervical adenocarcinomas (ECA) and endometrial adenocarcinomas (EMA) are uterine malignancies that have differing biological behaviors. The choice of an appropriate therapeutic plan rests on the tumor's si...

    Authors: Chiung-Ling Liao, Ming-Yung Lee, Yeu-Sheng Tyan, Lai-Fong Kok, Tina S Wu, Chiew-Loon Koo, Po-Hui Wang, Kuan-Chong Chao and Chih-Ping Han
    Citation: Journal of Translational Medicine 2009 7:37
  33. PAX2 is a transcription factor with an important role in embryogenic development. However, PAX2 expression was frequently identified in neoplasia responsible for the growth and survival of cancer cells. Due to...

    Authors: Antonia Busse, Anika Rietz, Stefan Schwartz, Eckhard Thiel and Ulrich Keilholz
    Citation: Journal of Translational Medicine 2009 7:36
  34. Th17 cells are CD4+ cells that produce interleukin 17 (IL-17) and are potent inducers of tissue inflammation and autoimmunity. We studied the levels of this T cell subset in peripheral blood of patients treate...

    Authors: Erika von Euw, Thinle Chodon, Narsis Attar, Jason Jalil, Richard C Koya, Begonya Comin-Anduix and Antoni Ribas
    Citation: Journal of Translational Medicine 2009 7:35
  35. Ginseng is believed to have beneficial effects against human diseases, and its active components, ginsenosides, may play critical roles in its diverse physiological actions. However, the mechanisms underlying ...

    Authors: Davy CW Lee, Cindy LH Yang, Stanley CC Chik, James CB Li, Jian-hui Rong, Godfrey CF Chan and Allan SY Lau
    Citation: Journal of Translational Medicine 2009 7:34
  36. The intravenous co-infusion of labradimil, a metabolically stable bradykinin B2 receptor agonist, has been shown to temporarily enhance the transvascular delivery of small chemotherapy drugs, such as carboplat...

    Authors: Hemant Sarin, Ariel S Kanevsky, Steve H Fung, John A Butman, Robert W Cox, Daniel Glen, Richard Reynolds and Sungyoung Auh
    Citation: Journal of Translational Medicine 2009 7:33
  37. The AAAS has announced the launch of Science Translational Medicine. This is further and critical recognition of this discipline and we are deeply gratified that translational medicine has risen to the level of r...

    Authors: Christian Brander and Francesco M Marincola
    Citation: Journal of Translational Medicine 2009 7:32
  38. Noninvasive detection of innate immune function such as the accumulation of neutrophils remains a challenge in many areas of clinical medicine. We hypothesized that granulocytes could generate volatile organic...

    Authors: Hye-Won Shin, Brandon J Umber, Simone Meinardi, Szu-Yun Leu, Frank Zaldivar, Donald R Blake and Dan M Cooper
    Citation: Journal of Translational Medicine 2009 7:31
  39. Low birth weight has been related to an increased risk for developing high blood pressure in adult life. The molecular and cellular analysis of umbilical cord artery and vein may provide information about the ...

    Authors: José Javier Martín de Llano, Graciela Fuertes, Isabel Torró, Consuelo García Vicent, José Luis Fayos and Empar Lurbe
    Citation: Journal of Translational Medicine 2009 7:30
  40. The stromal vascular fraction (SVF) of adipose tissue is known to contain mesenchymal stem cells (MSC), T regulatory cells, endothelial precursor cells, preadipocytes, as well as anti-inflammatory M2 macrophag...

    Authors: Neil H Riordan, Thomas E Ichim, Wei-Ping Min, Hao Wang, Fabio Solano, Fabian Lara, Miguel Alfaro, Jorge Paz Rodriguez, Robert J Harman, Amit N Patel, Michael P Murphy, Roland R Lee and Boris Minev
    Citation: Journal of Translational Medicine 2009 7:29
  41. Vitamin D insufficiency is common in hospitalized patients. Recent evidence suggests that vitamin D may enhance the innate immune response by induction of cathelicidin (LL-37), an endogenous antimicrobial pept...

    Authors: Leo Jeng, Alexandra V Yamshchikov, Suzanne E Judd, Henry M Blumberg, Gregory S Martin, Thomas R Ziegler and Vin Tangpricha
    Citation: Journal of Translational Medicine 2009 7:28
  42. It has been suggested that the initial differentiation of endothelial and hematopoietic cells during embryogenesis occurs from a common progenitor, called hemangioblast (hB). We hypothesized that these cells w...

    Authors: Grzegorz Wladyslaw Basak, Satoshi Yasukawa, Andre Alfaro, Samantha Halligan, Anand S Srivastava, Wei-Ping Min, Boris Minev and Ewa Carrier
    Citation: Journal of Translational Medicine 2009 7:27
  43. Mutations in GJB2 are the most common molecular defects responsible for autosomal recessive nonsyndromic hearing impairment (NSHI). The mutation spectra of this gene vary among different ethnic groups.

    Authors: Pu Dai, Fei Yu, Bing Han, Xuezhong Liu, Guojian Wang, Qi Li, Yongyi Yuan, Xin Liu, Deliang Huang, Dongyang Kang, Xin Zhang, Huijun Yuan, Kun Yao, Jinsheng Hao, Jia He, Yong He…
    Citation: Journal of Translational Medicine 2009 7:26
  44. Endocervical adenocarcinomas (ECAs) and endometrial adenocarcinomas (EMAs) are malignancies that affect uterus; however, their biological behaviors are quite different. This distinction has clinical significan...

    Authors: Chiew-Loon Koo, Lai-Fong Kok, Ming-Yung Lee, Tina S Wu, Ya-Wen Cheng, Jeng-Dong Hsu, Alexandra Ruan, Kuan-Chong Chao and Chih-Ping Han
    Citation: Journal of Translational Medicine 2009 7:25
  45. We have previously reported that the sigma-2 receptor is highly expressed in pancreas cancer. Furthermore, we have demonstrated that sigma-2 receptor specific ligands induce apoptosis in a dose-dependent fashi...

    Authors: Hiroyuki Kashiwagi, Jonathan E McDunn, Peter O Simon Jr, Peter S Goedegebuure, Suwanna Vangveravong, Katherine Chang, Richard S Hotchkiss, Robert H Mach and William G Hawkins
    Citation: Journal of Translational Medicine 2009 7:24
  46. The norovirus group (NVG) of caliciviruses are the etiological agents of most institutional outbreaks of gastroenteritis in North America and Europe. Identification of NVG is complicated by the non-culturable ...

    Authors: David N Fisman, Amy L Greer, George Brouhanski and Steven J Drews
    Citation: Journal of Translational Medicine 2009 7:23
  47. Resveratrol (RES), an estrogen analog, is considered as a potential cancer chemo-preventive agent. However, it remains unclear how RES is transported into cells. In this study, we observed that Caveolin-1(CAV1...

    Authors: Hui-ling Yang, Wei-qiong Chen, Xuan Cao, Andrea Worschech, Li-fen Du, Wei-yi Fang, Yang-yan Xu, David F Stroncek, Xin Li, Ena Wang and Francesco M Marincola
    Citation: Journal of Translational Medicine 2009 7:22
  48. Assessment of T-cell diversity, besides giving insights about the molecular basis of tumor antigen recognition, has clinical implications since it provides criteria for evaluating antigen-specific T cells clin...

    Authors: Federico Serana, Alessandra Sottini, Luigi Caimi, Belinda Palermo, Pier Giorgio Natali, Paola Nisticò and Luisa Imberti
    Citation: Journal of Translational Medicine 2009 7:21

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