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Volume 9 Supplement 1

Differential use of CCR5 vs. CXCR4 by HIV-1. Pathogenic, Translational and Clinical Open Questions

Reviews

Edited by Guido Poli and Luigi Buonaguro

  1. Content type: Review

    The human immunodeficiency virus type 1 (HIV-1) external envelope glycoprotein gp120 presents conserved binding sites for binding to the primary virus receptor CD4 as well as the major HIV chemokine coreceptor...

    Authors: Maria Tagliamonte, Maria Lina Tornesello, Franco M Buonaguro and Luigi Buonaguro

    Citation: Journal of Translational Medicine 2011 9(Suppl 1):S1

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  2. Content type: Review

    Entry coreceptor use by HIV-1 plays a pivotal role in viral transmission, pathogenesis and disease progression. In many HIV-1 infected individuals, there is an expansion in coreceptor use from CCR5 to include ...

    Authors: Lamorris M Loftin, Martha Kienzle, Yanjie Yi and Ronald G Collman

    Citation: Journal of Translational Medicine 2011 9(Suppl 1):S3

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  3. Content type: Review

    Natural antibodies constitute a first-line of defence against pathogens; they may also play other roles in immune regulation and homeostasis, through their ability to bind host antigens, surface molecules and ...

    Authors: Lucia Lopalco

    Citation: Journal of Translational Medicine 2011 9(Suppl 1):S4

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  4. Content type: Review

    The identification of phenotypically distinct HIV-1 variants with different prevalence during the progression of the disease has been one of the earliest discoveries in HIV-1 biology, but its relevance to AIDS...

    Authors: Hanneke Schuitemaker, Angélique B van 't Wout and Paolo Lusso

    Citation: Journal of Translational Medicine 2011 9(Suppl 1):S5

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  5. Content type: Review

    To enter target cells HIV-1 uses CD4 and a coreceptor. In vivo the coreceptor function is provided either by CCR5 (for R5) or CXCR4 (for X4 HIV-1). Although both R5 and X4 HIV-1 variants are present in body fluid...

    Authors: Jean-Charles Grivel, Robin J Shattock and Leonid B Margolis

    Citation: Journal of Translational Medicine 2011 9(Suppl 1):S6

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  6. Content type: Review

    SIV or SHIV infection of nonhuman primates (NHP) has been used to investigate the impact of coreceptor usage on the composition and dynamics of the CD4+ T cell compartment, mechanisms of disease induction and ...

    Authors: Silvana Tasca Sina, Wuze Ren and Cecilia Cheng-Mayer

    Citation: Journal of Translational Medicine 2011 9(Suppl 1):S7

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  7. Content type: Review

    Susceptibility to infection by the human immunodeficiency virus type-1 (HIV-1), both in vitro and in vivo, requires the interaction between its envelope (Env) glycoprotein gp120 Env and the primary receptor (R), ...

    Authors: Samanta A Mariani, Elisa Vicenzi and Guido Poli

    Citation: Journal of Translational Medicine 2011 9(Suppl 1):S8

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  8. Content type: Review

    Since the discovery of CCR5 as a coreceptor for HIV entry, there has been interest in blockade of the receptor for treatment and prevention of HIV infection. Although several CCR5 antagonists have been evaluat...

    Authors: Bruce L Gilliam, David J Riedel and Robert R Redfield

    Citation: Journal of Translational Medicine 2011 9(Suppl 1):S9

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