Volume 13 Supplement 1

Melanoma Bridge 2014: meeting abstracts

Meeting abstracts

Edited by Paolo A Ascierto, Gennaro Ciliberto, John M Kirkwood, Francesco M Marincola, Giuseppe Masucci, Ignacio Melero, Nicola Mozzillo, Giuseppe Palmieri and Magdalena Thurin.

The publication charges for this supplement were funded by 3P solution. Abstracts were evaluated by the Supplement Editors. Supplement Editor declarations: John Kirkwood reports grants from Prometheus and personal fees from BMS, Merck, GSK, Celgene, Vica and Ziopharm Oncology. Ignacio Melero has received consulting honoraria from Bristol Myers Squibb, Roche Genentech and Astra Zeneca. All other Supplement Editors declare that they have no competing interests.

Melanoma Bridge Meeting 2014. Go to conference site.

Naples, Italy3-6 December 2014

Concatenated PDF 13S1

The multi-faceted roles of the PI3K-AKT pathway in melanoma

Authors: Michael A Davies

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K1

Content type: Keynote speaker presentation Published on: 15 January 2015
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Evolution of resistance to MAPK-targeted therapies

Authors: Roger Lo

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K2

Content type: Keynote speaker presentation Published on: 15 January 2015
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ErbB3 plays a key role in the early phase of establishment of resistance to BRAF and/or MEK inhibitors

Authors: Luigi Fattore, Debora Malpicci, Emanuele Marra, Rosalba Camerlingo, Giuseppe Roscilli, Francesca Belleudi, Antoni Ribas, Rita Mancini, Maria Rosaria Torrisi, Luigi Aurisicchio, Paolo Antonio Ascierto and Gennaro Ciliberto

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K3

Content type: Keynote speaker presentation Published on: 15 January 2015
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Molecular enhancement of sentinel node evaluation

Authors: Alistair J Cochran

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K4

Content type: Keynote speaker presentation Published on: 15 January 2015
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Mechanisms of synergy of radiotherapy and immunotherapy

Authors: Karsten A Pilones, Ryan Emerson, Silvia C Formenti, Harlan S Robbins and Sandra Demaria

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K5

Content type: Keynote speaker presentation Published on: 15 January 2015
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Novel combination therapies for BRAF-mutant melanoma

Authors: Grant A McArthur

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K6

Content type: Keynote speaker presentation Published on: 15 January 2015
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Strategies and designs for combination immune therapy

Authors: Samir Khleif

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K7

Content type: Keynote speaker presentation Published on: 15 January 2015
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Combining targeted and immunotherapy: BRAF inhibitor dabrafenib (D) ± the MEK inhibitor trametinib (T) in combination with ipilimumab (Ipi) for V600E/K mutation-positive unresectable or metastatic melanoma (MM)

Authors: Igor Puzanov

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K8

Content type: Keynote speaker presentation Published on: 15 January 2015
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MEK + CDK4 a regimen for non-BRAF V6000 melanoma

Authors: Jeff Sosman

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K9

Content type: Keynote speaker presentation Published on: 15 January 2015
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Combining radiation therapy with immunotherapy: clinical translation

Authors: Silvia C Formenti

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K10

Content type: Keynote speaker presentation Published on: 15 January 2015
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Surgery in the combination therapies era

Authors: Nicola Mozzillo

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K11

Content type: Keynote speaker presentation Published on: 15 January 2015
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Grp94-specific monoclonal antibody to counteract BRAF inhibitor resistance in BRAF^V600E melanoma

Authors: F Sabbatino, E Favoino, Y Wang, X Wang, V Villani, L Cai, L Yang, S Ferrone and CR Ferrone

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K12

Content type: Keynote speaker presentation Published on: 15 January 2015
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Targeting multiple inhibitory receptors to reverse melanoma-induced T cell dysfunction

Authors: Hassane M Zarour

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K14

Content type: Keynote speaker presentation Published on: 15 January 2015
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Role of signal transduction and microRNAs on the immunogenicity of melanoma cells

Authors: Stefanie Meyer, Diana Handke, Anja Mueller, Anne Meinhardt, Simon Jasinski-Bergner, Stephan Mages, Juergen Bukur, Marco Donia, PerThor Straten and Barbara Seliger

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K15

Content type: Keynote speaker presentation Published on: 15 January 2015
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Advances in adoptive cellular therapy of cancer

Authors: David Stroncek

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K16

Content type: Keynote speaker presentation Published on: 15 January 2015
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Molecular and cellular basis for immunomodulation with monoclonal antibodies

Authors: Ignacio Melero

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K17

Content type: Keynote speaker presentation Published on: 15 January 2015
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Genetic heterogeneity and transcriptional plasticity drive resistance during immunotherapy and targeted therapy

Authors: Reinard Dummer

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K18

Content type: Keynote speaker presentation Published on: 15 January 2015
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The immune-related role of BRAF in melanoma

Authors: Sara Tomei, Davide Bedognetti, Valeria De Giorgi, Michele Sommariva, Sara Civini, Jennifer Reinboth, Muna Al Hashmi, Maria Libera Ascierto, Qiuzhen Liu, Ben D Ayotte, Andrea Worschech, Lorenzo Uccellini, Paolo A Ascierto, David Stroncek, Giuseppe Palmieri, Lotfi Chouchane…

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K19

Content type: Keynote speaker presentation Published on: 15 January 2015
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Is there a role for immune checkpoint blockade in metastatic uveal melanoma?

Authors: Bastian Schilling, Tim Schneider, Inga Möller, Antje Sucker, Annette Paschen, Dirk Schadendorf and Klaus G. Griewank

Citation: Journal of Translational Medicine 2015 13(Suppl 1):K20

Content type: Keynote speaker presentation Published on: 15 January 2015
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Cytokine Induced Killer cells effectively kill chemo-resistant melanoma cancer stem cells

Authors: Loretta Gammaitoni, Lidia Giraudo, Valeria Leuci, Giulia Mesiano, Michela Cangemi, Alessandro Zaccagna, Alberto Pisacane, Susanna Gallo, Fabrizio Carnevale-Schianca, Massimo Aglietta and Dario Sangiolo

Citation: Journal of Translational Medicine 2015 13(Suppl 1):O1

Content type: Oral presentation Published on: 15 January 2015
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RSK1 activation promotes invasion in nodular melanoma

Authors: Amel Salhi, Joshua A Farhadian, Keith M. Giles, Eleazar Vega-Saenz de Miera, Ines P. Silva, Caitlin Bourque, Karen Yeh, Sagar Chhangawala, Jinhua Wang, Fei Ye, David Y. Zhang, Eva Hernando, Yariv Houvras and Iman Osman

Citation: Journal of Translational Medicine 2015 13(Suppl 1):O2

Content type: Oral presentation Published on: 15 January 2015
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Long-term overall survival from a phase I trial using intratumoral plasmid interleukin-12 with electroporation in patients with melanoma

Authors: Adil Daud, Kathryn Toshimi Takamura, Tu Diep, Richard Heller and Robert H. Pierce

Citation: Journal of Translational Medicine 2015 13(Suppl 1):O3

Content type: Oral presentation Published on: 15 January 2015
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coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated BRAF^V600 mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519)

Authors: Paolo A Ascierto, Grant A. McArthur, Brigitte Dréno, James Larkin, Gabriella Liszkay, Michele Maio, Mario Mandala, Lev Demidov, Daniil Stroyakovskiy, Luc Thomas, Luis de la Cruz-Merino, Victoria Atkinson, Caroline Dutriaux, Claus Garbe, Ilsung Chang, Stephen P. Hack…

Citation: Journal of Translational Medicine 2015 13(Suppl 1):O4

Content type: Oral presentation Published on: 15 January 2015
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A randomized controlled comparison of pembrolizumab and chemotherapy in patients with ipilimumab-refractory melanoma

Authors: Reinhard Dummer, Adil Daud, Igor Puzanov, Omid Hamid, Dirk Schadendorf, Caroline Robert, Jacob Schachter, Anna Pavlick, Rene Gonzalez, F Stephen Hodi, Lee D. Cranmer, Christian Blank, Steven J. O’Day, Paolo A. Ascierto, April K. S. Salama, Nicole Xiaoyun Li…

Citation: Journal of Translational Medicine 2015 13(Suppl 1):O5

Content type: Oral presentation Published on: 15 January 2015
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Nivolumab improved survival vs dacarbazine in patients with untreated advanced melanoma

Authors: Georgina V Long, Victoria Atkinson, Paolo A Ascierto, Benjamin Brady, Caroline Dutriaux, Michele Maio, Laurent Mortier, Jessica C. Hassel, Piotr Rutkowski, Catriona McNeil, Ewa Kalinka-Warzocha, Kerry J. Savage, Micaela Hernberg, Celeste Lebbé, Julie Charles, Catalin Mihalcioiu…

Citation: Journal of Translational Medicine 2015 13(Suppl 1):O6

Content type: Oral presentation Published on: 15 January 2015
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Ipilimumab treatment decreases circulating Tregs and GrMDSC while enhancing CD4+ T cell activation

Authors: Yago Pico de Coaña, Maria Wolodarski, Giusy Gentilcore, Yuya Yoshimoto, Isabel Poschke, Johan Hansson, Giuseppe V Masucci and Rolf Kiessling

Citation: Journal of Translational Medicine 2015 13(Suppl 1):O7

Content type: Oral presentation Published on: 15 January 2015
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Analysis of T and NK cells immune response in Ipilimumab treated Melanoma patients

Authors: Rossana Tallerico, Costanza M Cristiani, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, Ester Simeone, Andrea Dominijanni, Antonio M Grimaldi, Francesco Colucci, Paolo A Ascierto and Ennio Carbone

Citation: Journal of Translational Medicine 2015 13(Suppl 1):O8

Content type: Oral presentation Published on: 15 January 2015
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Tumor-infiltrating lymphocytes predict cutaneous melanoma survival

Authors: Cristina Fortes, Simona Mastroeni, Thomas Manooranparanpampil, Francesca Passarelli, Alba Zappalà, Claudia Marino, Nicoletta Russo and Paola Michelozzi

Citation: Journal of Translational Medicine 2015 13(Suppl 1):O9

Content type: Oral presentation Published on: 15 January 2015
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αβ-Double Negative CD4/CD8 (CD56) T cell (DNTs) in metastatic melanoma: basal frequency and behaviour during Ipilimumab treatment. Preliminary evaluations

Authors: Giacoma De Tullio, Sabino Strippoli, Rosa Angarano, Vincenza De Fazio, Nicola Sgherza, Antonio Negri, Anna Albano, Pasquale Iacopino, Attilio Guarini and Michele Guida

Citation: Journal of Translational Medicine 2015 13(Suppl 1):O10

Content type: Oral presentation Published on: 15 January 2015
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Intratumoral electroporation of plasmid interleukin-12: efficacy and biomarker analyses from a phase 2 study in melanoma (OMS-I100)

Authors: Adil Daud, Alain Algazi, Michelle Ashworth, Michael Buljan, Kathryn Toshimi Takamura, Tu Diep, Robert H Pierce and Shailender Bhatia

Citation: Journal of Translational Medicine 2015 13(Suppl 1):O11

Content type: Oral presentation Published on: 15 January 2015
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AurkA inhibitors enhance the effects of B-RAF and MEK inhibitors in melanoma treatment

Authors: Emilia Caputo, Roberta Miceli, Maria L. Motti, Rosarita Taté, Federica Fratangelo, Gerardo Botti, Nicola Mozzillo, Maria V Carriero, Ernesta Cavalcanti, Giuseppe Palmieri, Gennaro Ciliberto, Giuseppe Pirozzi and Paolo A Ascierto

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P1

Content type: Poster presentation Published on: 15 January 2015
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Exome sequencing in primary melanoma identifies novel drivers of melanoma progression

Authors: Valentina Montagnani, Matteo Benelli, Alessandro Apollo, Silvia Pandolfi, Gianni Gerlini, Lorenzo Borgognoni and Barbara Stecca

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P2

Content type: Poster presentation Published on: 15 January 2015
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The relevance of BRAF G469A mutation in determining the response to therapy in metastatic melanoma

Authors: Letizia Porcelli, Gabriella Guida, Tiziana Cocco, Anna E. Quatrale, Rosa M Iacobazzi, Diana A Stolfa, Imma Maida, Anna Ferretta, Claudia Grieco, Stefania Guida, Sabino Strippoli, Stefania Tommasi, Michele Guida and Amalia Azzariti

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P3

Content type: Poster presentation Published on: 15 January 2015
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microRNAs and next generation sequencing for the prognosis of the metastatic melanoma

Authors: Rosamaria Pinto, Simona De Summa, Sabino Strippoli, Gabriella Guida, Ondina Popescu, Amalia Azzariti, Michele Guida and Stefania Tommasi

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P4

Content type: Poster presentation Published on: 15 January 2015
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Melanoma cells with acquired resistance to dabrafenib display changes in miRNA expression pattern and respond to this drug with an increase of invasiveness, which is abrogated by inhibition of NF-κB or the PI3K/mTOR signalling pathway

Authors: Simona Caporali, Ester Alvino, Adriana Amaro, Pedro Miguel Lacal, Lauretta Levati, Maria Grazia Atzori, Gian Carlo Antonini Cappellini, Federica Ruffini, Enzo Bonmassar, Ulrich Pfeffer and Stefania D’Atri

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P5

Content type: Poster presentation Published on: 15 January 2015
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Neuropilin-1 expressing melanoma cells as a model to study the aggressiveness of metastatic melanoma

Authors: Federica Ruffini, Grazia Graziani, Lauretta Levati, Lucio Tentori, Simona Caporali, Stefania D’Atri and Pedro M Lacal

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P6

Content type: Poster presentation Published on: 15 January 2015
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Safety and efficacy of vemurafenib in BRAF V600E mutation-positive metastatic melanomas

Authors: Andrea P Sponghini, David Rondonotti, Marco Giavarra, Roberto Giorgione and Francesca Platini

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P7

Content type: Poster presentation Published on: 15 January 2015
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BRAFV600E mutation positive metastatic melanoma in a young woman treated with anti-BRAF/anti MEK combination: a case report

Authors: Sara Giovannoni, Federica Urbano, Daniela Modica, Sofia Verkhovskaia, Giuliana Caprio, Silvia Mezi and Enrico Cortesi

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P8

Content type: Poster presentation Published on: 15 January 2015
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Simultaneous determination of two serum tumor markers in assessing malignant melanoma patients

Authors: Angela Sandru, Silviu Voinea, Eugenia Panaitescu, Madalina Bolovan, Adina Stanciu, Sabin Cinca and Alexandru Blidaru

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P9

Content type: Poster presentation Published on: 15 January 2015
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Clinical value of Melanoma Inhibitory Activity in stratifying malignant melanoma patients

Authors: Angela Sandru, Silviu Voinea, Eugenia Panaitescu, Madalina Bolovan, Adina Stanciu, Sabin Cinca and Alexandru Blidaru

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P10

Content type: Poster presentation Published on: 15 January 2015
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Melanoma Inhibitory Activity and regional lymph node status in malignant melanoma patients

Authors: Angela Sandru, Silviu Voinea, Eugenia Panaitescu, Madalina Bolovan, Adina Stanciu, Sabin Cinca and Alexandru Blidaru

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P11

Content type: Poster presentation Published on: 15 January 2015
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Immune infiltrates impact on the prediction of prognosis and response to immunotherapy of melanoma patients

Authors: Angela Vasaturo, Dagmar Verweij, Lucie Heinzerling, Jolanda de Vries, Willeke Blokx and Carl G Figdor

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P12

Content type: Poster presentation Published on: 15 January 2015
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Gender differences and outcome of melanoma patients

Authors: Francesca Morgese, Rossana Berardi, Caterina Sampaolesi, Mariangela Torniai, Giulia Marcantognini, Alfredo Giacchetti, Stefano Serresi, Azzurra Onofri, Alessandro Bittoni, Alberta Pilone, Giuseppe Ricotti and Stefano Cascinu

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P13

Content type: Poster presentation Published on: 15 January 2015
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Circulating dendritic cell levels identify high-risk stage II-III melanoma patients: a potential role as additional prognostic marker

Authors: Stefania Stucci, Marco Tucci, Anna Passarelli, Francesco Mannavola, Claudia Felici, Giuseppe Giudice and Franco Silvestris

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P14

Content type: Poster presentation Published on: 15 January 2015
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Dendritic cell-derived exosomes (Dex) are potential biomarkers of response to Ipilimumab in metastatic melanoma

Authors: Stefania Stucci, Marco Tucci, Paolo Antonio Ascierto, Anna Passarelli, Capone Mariaelena, Gabriele Madonna, Simeone Ester, Antonio Maria Grimaldi and Franco Silvestris

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P15

Content type: Poster presentation Published on: 15 January 2015
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“Immune B Cells know it better”: tumorimmunological panel assay to define tumor-associated antigen binding antibodies in patients with metastatic melanomas

Authors: Beatrix Kotlan, Timea Balatoni, Katalin Csirbesz, Judit Olasz, Orsolya Csuka, Laszlo Toth, Emil Farkas, Akos Savolt, Andras Szollar, Mihaly Ujhelyi, Szabolcs Horvath, Klara Eles, Miklos Kasler, Francesco M Marincola and Gabriella Liszkay

Citation: Journal of Translational Medicine 2015 13(Suppl 1):P16

Content type: Poster presentation Published on: 15 January 2015
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