Volume 13 Supplement 1

Melanoma Bridge 2014: meeting abstracts

Open Access

Tumor-infiltrating lymphocytes predict cutaneous melanoma survival

  • Cristina Fortes1,
  • Simona Mastroeni1,
  • Thomas Manooranparanpampil1,
  • Francesca Passarelli2,
  • Alba Zappalà3,
  • Claudia Marino4,
  • Nicoletta Russo5 and
  • Paola Michelozzi4
Journal of Translational Medicine201513(Suppl 1):O9


Published: 15 January 2015


Tumor-infiltrating lymphocytes (TILs) is considered a manifestation of the host immune response to tumor, but the role of TILs on melanoma mortality is controversial. Therefore, the aim of this study was to investigate the role of TILs on melanoma mortality, controlling for all known histological prognostic parameters.

Materials and methods

We conducted a 10-year cohort study among 4143 patients from the same geographic area (Lazio) with primary cutaneous melanoma diagnosed between January 1998 and December 2008. Survival probability was determined by Kaplan–Meier estimates, and prognostic factors were evaluated by multivariate analysis (Cox proportional hazards model).


Survival decreased with increasing age (P for trend < 0.001) and Breslow thickness (P for trend < 0.001). In the multivariate Cox model, the presence of high levels of tumour infiltrating immune cells in primary invasive melanomas was associated with lower risk of melanoma death (RR: 0.32; 95%CI:0.13-0.82, P for trend <0.001), after controlling for sex, age, breslow thickness, histological type, mitotic rate and ulceration.


These results suggest that immune microenvironment affects melanoma survival. Understanding differences in survival across distinct subgroups of melanoma patients may help choosing types of therapy.

Authors’ Affiliations

Epidemiology Unit, IDI-IRCCS
Pathology Unit, IDI-IRCCS
Oncology Unit , IDI-IRCCS
Department of Epidemiology of the Regional Health Service
Medical Direction, IDI-IRCCS


© Fortes et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.