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  1. Hypothermia, leading to mitochondrial inhibition, is widely used to reduce ischemic injury during kidney preservation. However, the exact effect of hypothermic kidney preservation on mitochondrial function rem...

    Authors: Koen D. W. Hendriks, Isabel M. A. Brüggenwirth, Hanno Maassen, Albert Gerding, Barbara Bakker, Robert J. Porte, Robert H. Henning and Henri G. D. Leuvenink

    Citation: Journal of Translational Medicine 2019 17:265

    Content type: Research

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  2. Diabetic nephropathy (DN) affects about 40% of diabetes mellitus (DM) patients and is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) all over the world, especially in high...

    Authors: Gang Wang, Jian Ouyang, Shen Li, Hui Wang, Baofeng Lian, Zhihong Liu and Lu Xie

    Citation: Journal of Translational Medicine 2019 17:264

    Content type: Research

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  3. Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disorder and represents the leading cause of food impaction. The pathogenesis of EoE is the result of an interplay between genetic, envi...

    Authors: Elena Cavalli, Andrea Brusaferro, Elena Sofia Pieri, Rita Cozzali, Edoardo Farinelli, Gian Luigi de’ Angelis and Susanna Esposito

    Citation: Journal of Translational Medicine 2019 17:262

    Content type: Review

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  4. Cell therapy has been proposed for patients with critical limb ischemia (CLI). Autologous bone marrow derived cells (BMCs) have been mostly used, mesenchymal stem cells (MSCs) being an alternative. The aim of ...

    Authors: Rida Al-Rifai, Philippe Nguyen, Nicole Bouland, Christine Terryn, Lukshe Kanagaratnam, Gaël Poitevin, Caroline François, Catherine Boisson-Vidal, Marie-Antoinette Sevestre and Claire Tournois

    Citation: Journal of Translational Medicine 2019 17:261

    Content type: Research

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  5. Emerging evidences show that microRNA (miRNA) plays an important role in many human complex diseases. However, considering the inherent time-consuming and expensive of traditional in vitro experiments, more an...

    Authors: Kai Zheng, Zhu-Hong You, Lei Wang, Yong Zhou, Li-Ping Li and Zheng-Wei Li

    Citation: Journal of Translational Medicine 2019 17:260

    Content type: Research

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  6. Ovarian cancer is the leading cause of death in gynecological cancer. Cancer stem cells (CSCs) contribute to the occurrence, progression and resistance. Small nucleolar RNAs (SnoRNAs), a class of small molecul...

    Authors: Wenjing Zhu, Jumin Niu, Miao He, Liwen Zhang, Xuemei Lv, Fangxiao Liu, Longyang Jiang, Jing Zhang, Zhaojin Yu, Lin Zhao, Jia Bi, Yuanyuan Yan, Qian Wei, Hong Huo, Yue Fan, Yuzong Chen…

    Citation: Journal of Translational Medicine 2019 17:259

    Content type: Research

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  7. The rapid evolution of cell-based immunotherapies such as chimeric antigen receptor T-cells for treatment of hematological cancers has precipitated the need for a platform to expand these cells ex vivo in a sa...

    Authors: Claire Coeshott, Boah Vang, Mark Jones and Brian Nankervis

    Citation: Journal of Translational Medicine 2019 17:258

    Content type: Research

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  8. Lung cancer is the second most common cancer with an extremely poor overall survival rate. Post-transcriptional regulation of gene expression play many important roles in human cancer, and one of the potential...

    Authors: Shirong Zhang, Xiaochen Zhang, Wei Lei, Jiafeng Liang, Yasi Xu, Hailiang Liu and Shenglin Ma

    Citation: Journal of Translational Medicine 2019 17:257

    Content type: Research

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  9. The adipose afferent reflex (AAR), a sympatho-excitatory reflex, can promote the elevation of sympathetic nerve activity (SNA) and blood pressure (BP). Inflammation in the paraventricular nucleus (PVN) involve...

    Authors: Lei Ding, Ying Kang, Hang-Bing Dai, Fang-Zheng Wang, Hong Zhou, Qing Gao, Xiao-Qing Xiong, Feng Zhang, Tian-Run Song, Yan Yuan, Ming Liu, Guo-Qing Zhu and Ye-Bo Zhou

    Citation: Journal of Translational Medicine 2019 17:256

    Content type: Research

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  10. Individualized drug response prediction is vital for achieving personalized treatment of cancer and moving precision medicine forward. Large-scale multi-omics profiles provide unprecedented opportunities for p...

    Authors: Yanjun Xu, Qun Dong, Feng Li, Yingqi Xu, Congxue Hu, Jingwen Wang, Desi Shang, Xuan Zheng, Haixiu Yang, Chunlong Zhang, Mengting Shao, Mohan Meng, Zhiying Xiong, Xia Li and Yunpeng Zhang

    Citation: Journal of Translational Medicine 2019 17:255

    Content type: Research

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  11. Noninvasive and effective methods of early diagnosis of colorectal cancer (CRC) are underexplored. Inflammation is known to play an important role in the tumor microenvironment of CRC. Therefore, the aim of th...

    Authors: Dan Wang, Weitang Yuan, Yaping Wang, Qian Wu, Li Yang, Feng Li, Xinfeng Chen, Zhen Zhang, Weina Yu, Nomathamsanqa Resegofetse Maimela, Ling Cao, Dong Wang, Junxia Wang, Zhenqiang Sun, Jinbo Liu and Yi Zhang

    Citation: Journal of Translational Medicine 2019 17:253

    Content type: Research

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  12. Pooled testing, in which biological specimens from multiple subjects are combined into a testing pool and tested via a single test, is a common testing method for both surveillance and screening activities. Th...

    Authors: Ngoc T. Nguyen, Hrayer Aprahamian, Ebru K. Bish and Douglas R. Bish

    Citation: Journal of Translational Medicine 2019 17:252

    Content type: Research

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  13. Diabetic cardiomyopathy (DCM) is a common complication of diabetes and is characterized by chronic myocardial inflammation. Mesenchymal stem cell (MSC) infusions have recently been suggested to alleviate myoca...

    Authors: Liyuan Jin, Zihui Deng, Jinying Zhang, Chen Yang, Jiejie Liu, Weidong Han, Ping Ye, Yiling Si and Guanghui Chen

    Citation: Journal of Translational Medicine 2019 17:251

    Content type: Research

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  14. Here, we isolated, expanded and functionally characterized regulatory T cells (Tregs) from patients with end stage kidney and liver disease, waiting for kidney/liver transplantation (KT/LT), with the aim to es...

    Authors: Francesca Ulbar, Tiziana Montemurro, Tatiana Jofra, Miriam Capri, Giorgia Comai, Valentina Bertuzzo, Cristiana Lavazza, Alessandra Mandelli, Mariele Viganò, Silvia Budelli, Maria Giulia Bacalini, Chiara Pirazzini, Paolo Garagnani, Valeria Giudice, Daria Sollazzo, Antonio Curti…

    Citation: Journal of Translational Medicine 2019 17:250

    Content type: Research

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  15. Alloantibodies against human platelet antigens (HPAs) and human leukocyte antigen (HLA) are implicated in several immune-mediated platelet disorders. Detection of these antibodies is crucial in the diagnosis a...

    Authors: Sudan Tao, Shu Chen, Xiaozhen Hong, Ji He and Faming Zhu

    Citation: Journal of Translational Medicine 2019 17:249

    Content type: Research

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  16. The relationship between the tissue injury healing response and development of heterotopic ossification (HO) is poorly understood. Here we compare a rat blast model and human traumatized muscle from a blast in...

    Authors: Jaira F. de Vasconcellos, Sonia Zicari, Stephen D. Fernicola, Daniel W. Griffin, Youngmi Ji, Emily H. Shin, Patrick Jones, Gregory T. Christopherson, Husain Bharmal, Carl Cirino, Thao Nguyen, Astor Robertson, Vincent D. Pellegrini Jr. and Leon J. Nesti

    Citation: Journal of Translational Medicine 2019 17:248

    Content type: Research

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  17. The molecular pathways that drive bone marrow myeloid progenitors (BMMP) development are very well understood and include a tight controlled multi-stage gene hierarch. Monocytes are versatile cells that displa...

    Authors: Mariana Cabanel, Thayse Pinheiro da Costa, Marcia Cury EL-Cheikh and Katia Carneiro

    Citation: Journal of Translational Medicine 2019 17:247

    Content type: Research

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  18. Plexiform fibromyxoma (PF) is a rare gastric tumor often confused with gastrointestinal stromal tumor. These so-called “benign” tumors often present with upper GI bleeding and gastric outlet obstruction. It wa...

    Authors: Sudeep Banerjee, Christopher L. Corless, Markku M. Miettinen, Sangkyu Noh, Rowan Ustoy, Jessica L. Davis, Chih-Min Tang, Mayra Yebra, Adam M. Burgoyne and Jason K. Sicklick

    Citation: Journal of Translational Medicine 2019 17:246

    Content type: Research

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  19. Melanoma is one of the most aggressive cancers with extremely poor prognosis, and the median survival time for stage IV patients is approximately 6 to 8 months. Unlike cutaneous melanoma, mucosal melanoma is a...

    Authors: Longwen Xu, Zhiyuan Cheng, Chuanliang Cui, Xiaowen Wu, Huan Yu, Jun Guo and Yan Kong

    Citation: Journal of Translational Medicine 2019 17:245

    Content type: Research

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    The Correction to this article has been published in Journal of Translational Medicine 2019 17:358

  20. Mitochondrial DNA (mtDNA) haplogroups have been associated with advanced liver fibrosis and cirrhosis in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Our aim was to ...

    Authors: Teresa Aldámiz-Echevarría, Salvador Resino, José M. Bellón, María A. Jiménez-Sousa, Pilar Miralles, Luz M. Medrano, Ana Carrero, Cristina Díez, Leire Pérez-Latorre, Chiara Fanciulli, Pilar Garcia-Broncano and Juan Berenguer

    Citation: Journal of Translational Medicine 2019 17:244

    Content type: Research

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  21. Despite of medical advances, the number of patients suffering on non-healing chronic wounds is still increasing. This fact is attended by physical and emotional distress and an economic load. The majority of c...

    Authors: M. Besser, J. Terberger, L. Weber, B. Ghebremedhin, E. A. Naumova, W. H. Arnold and E. K. Stuermer

    Citation: Journal of Translational Medicine 2019 17:243

    Content type: Research

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  22. Current human influenza vaccines lack the adaptability to match the mutational rate of the virus and therefore require annual revisions. Because of extensive manufacturing times and the possibility that antige...

    Authors: Patrick Tjok Joe, Ioanna Christopoulou, Lien van Hoecke, Bert Schepens, Tine Ysenbaert, Carlo Heirman, Kris Thielemans, Xavier Saelens and Joeri L. Aerts

    Citation: Journal of Translational Medicine 2019 17:242

    Content type: Research

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  23. Cell-based therapies have the potential to become treatment options for many diseases, but efficient scale-out of these therapies has proven to be a major hurdle. Bioreactors can be used to overcome this hurdl...

    Authors: Ruud Das, Rens Roosloot, Melissa van Pel, Koen Schepers, Marijn Driessen, Willem E. Fibbe, Joost Dick de Bruijn and Helene Roelofs

    Citation: Journal of Translational Medicine 2019 17:241

    Content type: Research

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  24. The use of “off-the-shelf” cellular therapy products derived from healthy donors addresses many of the challenges associated with customized cell products. However, the potential of allogeneic cell products to...

    Authors: David H. Quach, Luis Becerra-Dominguez, Rayne H. Rouce and Cliona M. Rooney

    Citation: Journal of Translational Medicine 2019 17:240

    Content type: Research

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  25. Indoleamine 2,3-dioxygenase catalyzes the conversion of tryptophan to kynurenine, an immunosuppressive metabolite involved in T regulatory cell differentiation. Indoleamine 2,3-dioxygenase is expressed in many...

    Authors: Concetta Elisa Onesti, François Boemer, Claire Josse, Stephane Leduc, Vincent Bours and Guy Jerusalem

    Citation: Journal of Translational Medicine 2019 17:239

    Content type: Research

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  26. Wolfram syndrome (WS), a rare genetic disorder, is considered the best prototype of endoplasmic reticulum (ER) diseases. Classical WS features are childhood-onset diabetes mellitus, optic atrophy, deafness, di...

    Authors: Maria Teresa Pallotta, Giorgia Tascini, Roberta Crispoldi, Ciriana Orabona, Giada Mondanelli, Ursula Grohmann and Susanna Esposito

    Citation: Journal of Translational Medicine 2019 17:238

    Content type: Review

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  27. Obesity is a chronic and systemic inflammatory disorder and an important risk factor for the onset of several chronic syndromes. Adipose tissue (AT) plays a crucial role in the development of obesity, promotin...

    Authors: Federica Tomay, Alessandra Marinelli, Valerio Leoni, Claudio Caccia, Andrea Matros, Hans-Peter Mock, Chiara Tonelli and Katia Petroni

    Citation: Journal of Translational Medicine 2019 17:237

    Content type: Research

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  28. Diabetic nephropathy (DN) is associated with high risk of cardiovascular disease and mortality. Exosomal microRNAs (miRNAs) regulate gene expression in a variety of tissues and play important roles in the path...

    Authors: Hyoungnae Kim, Yun-Ui Bae, Jin Seok Jeon, Hyunjin Noh, Hyeong Kyu Park, Dong Won Byun, Dong Cheol Han, Seongho Ryu and Soon Hyo Kwon

    Citation: Journal of Translational Medicine 2019 17:236

    Content type: Research

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  29. Currently, in vivo model for personalised cancer drug testing is challenging. A zebrafish larvae xenograft model has been applied in recent years to cancer research, particularly for drug testing purposes, sho...

    Authors: Ahmed Al-Samadi, Katja Tuomainen, Anne Kivimäki, Abdelhakim Salem, Sakhr Al-Kubati, Aini Hyytiäinen, Mataleena Parikka, Karri Mesimäki, Tommy Wilkman, Antti Mäkitie, Reidar Grenman and Tuula Salo

    Citation: Journal of Translational Medicine 2019 17:235

    Content type: Research

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  30. Diagnosis of melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges in mel...

    Authors: Paolo A. Ascierto, Sanjiv S. Agarwala, Gerardo Botti, Alfredo Budillon, Michael A. Davies, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Silvia Formenti, Thomas F. Gajewski, Claus Garbe, Omid Hamid, Roger S. Lo, Jason J. Luke, Oliver Michielin, Giuseppe Palmieri…

    Citation: Journal of Translational Medicine 2019 17:234

    Content type: Meeting report

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  31. The use of one-step nucleic acid amplification (OSNA) allows for lymph node (LN) metastasis to be detected rapidly and accurately. We conducted a prospective single-centre clinical trial to evaluate OSNA assay...

    Authors: María Escalante Pérez, María Teresa Hermida Romero, Begoña Otero Alén, Mónica Álvarez Martínez, Ricardo Fernández Prado, Mercedes de la Torre Bravos and Ángel Concha López

    Citation: Journal of Translational Medicine 2019 17:233

    Content type: Research

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  32. Macrophage cholesterol efflux capacity has been identified as a predictor for cardiovascular disease. We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage chole...

    Authors: Matthew D. Barberio, Lora J. Kasselman, Martin P. Playford, Samuel B. Epstein, Heather A. Renna, Madeleine Goldberg, Joshua DeLeon, Iryna Voloshyna, Ashley Barlev, Michael Salama, Sarah C. Ferrante, Evan P. Nadler, Nehal Mehta, Allison B. Reiss and Robert J. Freishtat

    Citation: Journal of Translational Medicine 2019 17:232

    Content type: Research

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  33. Bone metastases occur rarely in patients suffering from malignant melanoma, although their onset severely worsens both prognosis and quality of life. Extracellular vesicles (EVs) including exosomes (Exos) are ...

    Authors: Francesco Mannavola, Marco Tucci, Claudia Felici, Anna Passarelli, Stella D’Oronzo and Francesco Silvestris

    Citation: Journal of Translational Medicine 2019 17:230

    Content type: Research

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  34. Chemotherapy-induced left ventricular dysfunction represents a major clinical problem, which is often only recognised at an advanced stage, when supportive therapy is ineffective. Although an early heart failu...

    Authors: Mária Lódi, Dániel Priksz, Gábor Áron Fülöp, Beáta Bódi, Alexandra Gyöngyösi, Lilla Nagy, Árpád Kovács, Attila Béla Kertész, Judit Kocsis, István Édes, Zoltán Csanádi, István Czuriga, Zoltán Kisvárday, Béla Juhász, István Lekli, Péter Bai…

    Citation: Journal of Translational Medicine 2019 17:229

    Content type: Research

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  35. Chronic kidney disease (CKD) is a universal chronic disease in China. The balance of the gut microbiome is highly crucial for a healthy human body, especially for the immune system. However, the relationship b...

    Authors: Yang Li, Xinhuan Su, Lei Zhang, Yanwei Liu, Min Shi, Chenxiao Lv, Ying Gao, Dongmei Xu and Zunsong Wang

    Citation: Journal of Translational Medicine 2019 17:228

    Content type: Research

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  36. Diabetes is a chronic disease associated with many problems and high costs. In recent decades, a lot of research has been carried out in order to improve methods of treatment of diabetic patients. One of the c...

    Authors: Fouad Mehraban, Arefeh Seyedarabi, Shahin Ahmadian, Vahid Mirzaaghaei and Ali Akbar Moosavi-Movahedi

    Citation: Journal of Translational Medicine 2019 17:227

    Content type: Research

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  37. Adrenocorticotrophic hormone (ACTH)-treatment rat model has been utilized as a widely accepted model of treatment-resistant depression. Metabolomic signatures represent the pathophysiological phenotype of dise...

    Authors: Jing Song, Weini Ma, Xinyi Gu, Le Zhao, Jiaye Jiang, Ying Xu, Lei Zhang, Mingmei Zhou and Li Yang

    Citation: Journal of Translational Medicine 2019 17:224

    Content type: Research

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  38. Drug development is currently hampered by high attrition rates; many developed treatments fail during clinical testing. Part of the attrition may be due to low animal-to-human translational success rates; so-c...

    Authors: Cathalijn H. C. Leenaars, Carien Kouwenaar, Frans R. Stafleu, André Bleich, Merel Ritskes-Hoitinga, Rob B. M. De Vries and Franck L. B. Meijboom

    Citation: Journal of Translational Medicine 2019 17:223

    Content type: Review

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  39. Type 1 diabetes mellitus (T1DM) patients display increased risk of cardiovascular disease (CVD) and are characterized by a diminished regulatory T (Treg) cell content or function. Previous studies have shown a...

    Authors: Sergio Martínez-Hervás, Verónica Sánchez-García, Andrea Herrero-Cervera, Ángela Vinué, José Tomás Real, Juan F. Ascaso, Deborah Jane Burks and Herminia González-Navarro

    Citation: Journal of Translational Medicine 2019 17:222

    Content type: Research

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  40. The clinical significance of stem cell therapy in the treatment of dilated cardiomyopathy remains unclear. This systemic appraisal and meta-analysis aimed to assess the efficacy and safety of stem cell therapy...

    Authors: Shu-Ling Rong, Ze-Kun Wang, Xue-Dong Zhou, Xiao-Lin Wang, Zhi-Ming Yang and Bao Li

    Citation: Journal of Translational Medicine 2019 17:221

    Content type: Research

    Published on:

  41. The influence of DNMT3A R882 mutations on adult acute myeloid leukemia (AML) prognosis is still controversial presently. The influence of R882 allele ratio on drug response and prognosis of AML is unknown yet. Be...

    Authors: Xiao-Qing Yuan, Peng Chen, Yin-Xiao Du, Ke-Wei Zhu, Dao-Yu Zhang, Han Yan, Han Liu, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Jing Yang, Wen-Jing Zeng and Xiao-Ping Chen

    Citation: Journal of Translational Medicine 2019 17:220

    Content type: Research

    Published on:

  42. The pleiotropic cytokine, transforming growth factor (TGF)-β, and CD4+CD25+Foxp3+ regulatory T cells (Tregs) play a critical role in actively suppressing antitumor immune responses. Evidence shows that TGF-β prod...

    Authors: Magdalena J. Polanczyk, Edwin Walker, Daniel Haley, Bella S. Guerrouahen and Emmanuel T. Akporiaye

    Citation: Journal of Translational Medicine 2019 17:219

    Content type: Research

    Published on:

  43. Immune infiltration may predict survival and have clinical significance in lung cancer. However, immune signatures derived from immune profiling based on bulk tumor transcriptomes have not been systematically ...

    Authors: Xiaodong Yang, Yu Shi, Ming Li, Tao Lu, Junjie Xi, Zongwu Lin, Wei Jiang, Weigang Guo, Cheng Zhan and Qun Wang

    Citation: Journal of Translational Medicine 2019 17:217

    Content type: Research

    Published on:

  44. New treatment options for metastasised high-grade serous carcinoma (HGSC) are urgently needed. HGSC frequently metastasises to the omentum, inducing angiogenesis in the local omental microvasculature to facili...

    Authors: Md Zahidul I. Pranjol, Dmitry A. Zinovkin, Annelie R. T. Maskell, Laura J. Stephens, Sergey L. Achinovich, Dmitry M. Los’, Eldar A. Nadyrov, Michael Hannemann, Nicholas J. Gutowski and Jacqueline L. Whatmore

    Citation: Journal of Translational Medicine 2019 17:216

    Content type: Research

    Published on:

  45. Tumor necrosis factor α (TNFα) is a multifunctional cytokine with a potent pro-inflammatory effect. It is a validated therapeutic target molecule for several disorders related to autoimmunity and inflammation....

    Authors: Madhu Sudhana Saddala and Hu Huang

    Citation: Journal of Translational Medicine 2019 17:215

    Content type: Research

    Published on:

  46. To evaluate the imaging biomarkers of human epidermal growth factor receptor 2 (HER2) positive breast cancer in comparison to other molecular subtypes and to determine the feasibility of identifying hormone re...

    Authors: Chao You, Jianwei Li, Wenxiang Zhi, Yanqiong Chen, Wentao Yang, Yajia Gu and Weijun Peng

    Citation: Journal of Translational Medicine 2019 17:182

    Content type: Research

    Published on:

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