Articles

The risk and added values of the atherosclerotic cardiovascular risk enhancers on prediction of cardiovascular events: Tehran lipid and glucose study

In 2013 American College of Cardiology and the American Heart Association released a guideline on the management of atherosclerotic cardiovascular disease (ASCVD) including a composite of death from CVD, non-f...

Authors: Farzad Hadaegh, Samaneh Asgari, Fatemeh Moosaie, Meysam Orangi, Farzaneh Sarvghadi, Davood Khalili and Fereidoun Azizi

Anti-migraine agents from an immunological point of view

The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs. CGRP, whil...

Authors: Bakri M. Assas

Amniotic fluid-derived multipotent stromal cells drive diabetic wound healing through modulation of macrophages

Cutaneous wounds in patients with diabetes exhibit impaired healing due to physiological impediments and conventional care options are severely limited. Multipotent stromal cells (MSCs) have been touted as a p...

Authors: Bibi S. Subhan, Jennifer Kwong, Joseph F. Kuhn, Arie Monas, Sonali Sharma and Piul S. Rabbani

Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge” (December 4th–5th, 2019, Naples, Italy)

Over the last few years, numerous clinical trials and real-world experience have provided a large amount of evidence demonstrating the potential for long-term survival with immunotherapy agents across various ...

Authors: Paolo A. Ascierto, Lisa H. Butterfield, Katie Campbell, Bruno Daniele, Michael Dougan, Leisha A. Emens, Silvia Formenti, Filip Janku, Samir N. Khleif, Tomas Kirchhoff, Alessandro Morabito, Yana Najjar, Paul Nathan, Kunle Odunsi, Akash Patnaik, Chrystal M. Paulos…

Immune responses to azacytidine in animal models of inflammatory disorders: a systematic review

Inflammatory disorders like diabetes, systemic lupus erythematodes, inflammatory lung diseases, rheumatoid arthritis and multiple sclerosis, but also rejection of transplanted organs and GvHD, form a major bur...

Authors: Sija Landman, Chiel van der Horst, Piet E. J. van Erp, Irma Joosten, Rob de Vries and Hans J. P. M. Koenen

Hypoxia and the phenomenon of immune exclusion

Over the last few years, cancer immunotherapy experienced tremendous developments and it is nowadays considered a promising strategy against many types of cancer. However, the exclusion of lymphocytes from the...

Authors: Violena Pietrobon and Francesco M. Marincola

Exosomal LncRNA LINC00659 transferred from cancer-associated fibroblasts promotes colorectal cancer cell progression via miR-342-3p/ANXA2 axis

Cancer-associated fibroblasts (CAFs) play a pivotal role in regulating tumor progression by transferring exosomes to adjacent cells. Our aim was to clarify the role of LINC00659 encapsulated in CAFs-derived ex...

Authors: Lin Zhou, Jian Li, Yaping Tang and Mei Yang

Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump

Treating severe forms of the acute respiratory distress syndrome and cardiac failure, extracorporeal membrane oxygenation (ECMO) has become an established therapeutic option. Neonatal or pediatric patients rec...

Authors: Malte Schöps, Sascha H. Groß-Hardt, Thomas Schmitz-Rode, Ulrich Steinseifer, Daniel Brodie, Johanna C. Clauser and Christian Karagiannidis

The evidence base for physiotherapy in myalgic encephalomyelitis/chronic fatigue syndrome when considering post-exertional malaise: a systematic review and narrative synthesis

Due to the inconsistent use of diagnostic criteria in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), it is unsure whether physiotherapeutic management regarded effective in ME/CFS is appropriate ...

Authors: Marjon E. A. Wormgoor and Sanne C. Rodenburg

Design of a companion bioinformatic tool to detect the emergence and geographical distribution of SARS-CoV-2 Spike protein genetic variants

Tracking the genetic variability of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) is a crucial challenge. Mainly to identify target sequences in order to generate robust vaccines and neutralizin...

Authors: Alice Massacci, Eleonora Sperandio, Lorenzo D’Ambrosio, Mariano Maffei, Fabio Palombo, Luigi Aurisicchio, Gennaro Ciliberto and Matteo Pallocca

Parkinson’s disease following COVID-19: causal link or chance occurrence?

Authors: Wei-Shan Li, Ling-Ling Chan, Yin-Xia Chao and Eng-King Tan

Correction to: Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)

An amendment to this paper has been published and can be accessed via the original article.

Authors: Do-Young Kim, Jin-Seok Lee, Samuel-Young Park, Soo-Jin Kim and Chang-Gue Son

Correction to: The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition

An amendment to this paper has been published and can be accessed via the original article.

Authors: Junfeng Sun, Chaohui Ding, Zhen Yang, Tao Liu, Xiefu Zhang, Chunlin Zhao and Jiaxiang Wang

COVID-19 biomarkers for severity mapped to polycystic ovary syndrome

Authors: Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin and Alexandra E. Butler

May the analysis of 1918 influenza pandemic give hints to imagine the possible magnitude of Corona Virus Disease-2019 (COVID-19)?

In 1918 an unknown infectious agent spread around the world infecting over one-third of the general population and killing almost 50 million people. Many countries were at war, the First World War. Since Spain...

Authors: Raffaele Scarpa, Francesco Caso, Luisa Costa, Saverio Passavanti, Maria Grazia Vitale, Claudia Trojaniello, Antonio Del Puente and Paolo A. Ascierto

Evaluation of the diagnostic accuracy of a new point-of-care rapid test for SARS-CoV-2 virus detection

The easy access to a quick diagnosis of coronavirus disease 2019 (COVID-19) is a key point to improve the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to contain its spread. U...

Authors: Leonardo Miscio, Antonio Olivieri, Francesco Labonia, Gianfranco De Feo, Paolo Chiodini, Giuseppe Portella, Luigi Atripaldi, Roberto Parrella, Rodolfo Conenna, Franco Maria Buonaguro, Ernesta Cavalcanti, Paolo Ascierto, Gerardo Botti and Attilio Bianchi

Donor-intrinsic variables determine mobilization efficiency: analyses from a cohort of sixty twice-mobilized stem cell donors

Healthy volunteer registry donors have become the backbone of stem cell transplantation programs. While most registrants will never become actual donors, a small minority are called upon twice, most commonly f...

Authors: Soo-Zin Kim-Wanner, Seo-Youn Lee, Erhard Seifried and Halvard Bonig

Survival differences by ethnicity among patients diagnosed with bladder cancer

Authors: Boda Guo and Ming Liu

Viruses belonging to Anelloviridae or Circoviridae as a possible cause of chronic fatigue

Chronic fatigue often starts with an acute viral infection—as witnessed in the case of SARS-CoV-2—but indirect consequences of these infections are presumably the actual cause of the condition. As recently rev...

Authors: Bjørn Grinde

Potential causal factors of CFS/ME: a concise and systematic scoping review of factors researched

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is understood as a complex condition, likely triggered and sustained by an interplay of biological, psychological, and social factors. Little oversig...

Authors: Ashley Elizabeth Muller, Kari Tveito, Inger Johanne Bakken, Signe A. Flottorp, Siri Mjaaland and Lillebeth Larun

Myeloid-derived suppressor cells therapy enhance immunoregulatory properties in acute graft versus host disease with combination of regulatory T cells

Myeloid-derived suppressor cells (MDSCs) play a critical role in modulating the immune response and promoting immune tolerance in models of autoimmunity and transplantation. Regulatory T cells (Tregs) exert th...

Authors: Min-Jung Park, Jin-Ah Baek, Se-Young Kim, Kyung-Ah Jung, Jeong Won Choi, Sung-Hwan Park, Seung‐Ki Kwok and Mi-La Cho

Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres

Driver genes of GBM may be crucial for the onset of isocitrate dehydrogenase (IDH)-wildtype (WT) glioblastoma (GBM). However, it is still unknown whether the genes are expressed in the identical cluster of cells....

Authors: Seon-Jin Yoon, Hye Young Son, Jin-Kyoung Shim, Ju Hyung Moon, Eui-Hyun Kim, Jong Hee Chang, Wan Yee Teo, Se Hoon Kim, Sahng Wook Park, Yong-Min Huh and Seok-Gu Kang

Human breast milk as source of sphingolipids for newborns: comparison with infant formulas and commercial cow’s milk

In the past two decades, sphingolipids have become increasingly appreciated as bioactive molecules playing important roles in a wide array of pathophysiology mechanisms. Despite advances in the field, sphingol...

Authors: Michele Dei Cas, Rita Paroni, Paola Signorelli, Alessandra Mirarchi, Laura Cerquiglini, Stefania Troiani, Samuela Cataldi, Michela Codini, Tommaso Beccari, Riccardo Ghidoni and Elisabetta Albi

The effectiveness of pediatric obesity prevention policies: a comprehensive systematic review and dose–response meta-analysis of controlled clinical trials

Childhood obesity persists as a serious public health problem. In the current meta-analysis, we summarized the results of controlled trials that evaluated the effect of obesity prevention policies in children ...

Authors: Shahnaz Taghizadeh and Mahdieh Abbasalizad Farhangi

The roles of osteocytes in alveolar bone destruction in periodontitis

Periodontitis, a bacterium-induced inflammatory disease that is characterized by alveolar bone loss, is highly prevalent worldwide. Elucidating the underlying mechanisms of alveolar bone loss in periodontitis ...

Authors: Xiaofei Huang, Mengru Xie, Yanling Xie, Feng Mei, Xiaofeng Lu, Xiaoshuang Li and Lili Chen

Plasma levels and tissue expression of soluble TGFβrIII receptor in women with early-stage breast cancer and in healthy women: a prospective observational study

Mammary carcinogenesis is partly regulated by the transforming growth factor beta (TGFβ) signaling pathway. Its function in cancer progression and metastasis is highly dependent on disease stage, and it is lik...

Authors: Lovorka Grgurevic, Ruder Novak, Vladimir Trkulja, Stela Hrkac, Grgur Salai, Josko Bilandzic, Lejla Ferhatovic Hamzic, Ivan Milas, Tiha Vucemilo, Melita Peric Balja and Karmen Bilic

Exogenous interleukin-33 promotes hepatocellular carcinoma growth by remodelling the tumour microenvironment

Interleukin-33 (IL-33) is an effective inducer of pro-inflammatory cytokines regulating innate and adaptive immunity. Inflammation could be a double-edged sword, promoting or inhibiting tumour growth. To date,...

Authors: Wenxiu Wang, Jun Wu, Mei Ji and Changping Wu

Circular RNA expression profiles and features in NAFLD mice: a study using RNA-seq data

Nonalcoholic fatty liver disease (NAFLD) is primarily characterized by the hepatic cholesterol accumulation. Circular RNA (circRNA), one of noncoding RNA, involves in many liver diseases progression. However, ...

Authors: Xinlu Yuan, Jianjun Diao, Anqing Du, Song Wen, Ligang Zhou and Yangbin Pan

PD-L1 expression in liver metastasis: its clinical significance and discordance with primary tumor in colorectal cancer

The outcomes of immune checkpoint inhibitors in cancer patients with liver metastases are poor, which may be related to a different tumor microenvironment in liver metastases from primary tumors. This study wa...

Authors: Xiao-Li Wei, Xuan Luo, Hui Sheng, Yun Wang, Dong-Liang Chen, Jia-Ning Li, Feng-Hua Wang and Rui-Hua Xu

Hypoxic exosomes orchestrate tumorigenesis: molecular mechanisms and therapeutic implications

The solid tumor microenvironment possesses a hypoxic condition, which promotes aggressiveness and resistance to therapies. Hypoxic tumor cells undergo broadly metabolic and molecular adaptations and communicat...

Authors: Reza Jafari, Reza Rahbarghazi, Mahdi Ahmadi, Mehdi Hassanpour and Jafar Rezaie

Cellular analysis of bronchoalveolar lavage fluid to narrow differential diagnosis of checkpoint inhibitor-related pneumonitis in metastatic melanoma

The diagnosis of check-point inhibitor-related pneumonitis (CIP) relies on radiological and clinical patterns which are not specific and can mimic other conditions (cancer progression, infectious diseases or i...

Authors: Sabino Strippoli, Livia Fucci, Antonio Negri, Daniela Putignano, Marco Luigi Cisternino, Gaetano Napoli, Ruggiero Filannino, Ivana De Risi, Angela Monica Sciacovelli and Michele Guida

Precision medicine in the era of artificial intelligence: implications in chronic disease management

Aberrant metabolism is the root cause of several serious health issues, creating a huge burden to health and leading to diminished life expectancy. A dysregulated metabolism induces the secretion of several mo...

Authors: Murugan Subramanian, Anne Wojtusciszyn, Lucie Favre, Sabri Boughorbel, Jingxuan Shan, Khaled B. Letaief, Nelly Pitteloud and Lotfi Chouchane

Non-invasive biomarkers for monitoring the immunotherapeutic response to cancer

Immunotherapy is an efficient way to cure cancer by modulating the patient’s immune response. However, the immunotherapy response is heterogeneous and varies between individual patients and cancer subtypes, re...

Authors: Sabah Nisar, Ajaz A. Bhat, Sheema Hashem, Santosh K. Yadav, Arshi Rizwan, Mayank Singh, Puneet Bagga, Muzafar A. Macha, Michael P. Frenneaux, Ravinder Reddy and Mohammad Haris

Prophylactic, single-drug cardioprotection in a comparative, experimental study of doxorubicin-induced cardiomyopathy

Cardiomyopathy is a common side effect of doxorubicin (DOX) chemotherapy. Despite intensive research efforts in the field, there is still no evidence available for routine cardioprotective prophylaxis to preve...

Authors: Mária Lódi, Viktor Bánhegyi, Beáta Bódi, Alexandra Gyöngyösi, Árpád Kovács, Anita Árokszállási, Nazha Hamdani, Miklós Fagyas, István Édes, Zoltán Csanádi, István Czuriga, Zoltán Kisvárday, István Lekli, Péter Bai, Attila Tóth, Zoltán Papp…

Different expression pattern of human cytomegalovirus-encoded microRNAs in circulation from virus latency to reactivation

Human cytomegalovirus (HCMV) is a beta-hersvirinae that has a high latent infection rate worldwide and can cause serious consequences in immunocompromised patients when reactivation; however, the mechanism of ...

Authors: Wanqing Zhou, Cheng Wang, Meng Ding, Yuying Bian, Yujie Zhong, Han Shen, Junjun Wang, Chen-Yu Zhang and Chunni Zhang

Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes

In pre-clinical research, systematic reviews have the potential to mitigate translational challenges by facilitating understanding of how pre-clinical studies can inform future clinical research. Yet their con...

Authors: Nicola L. Harman, Adrián Sanz-Moreno, Stamatia Papoutsopoulou, Katie A. Lloyd, Kamar E. Ameen-Ali, Malcolm Macleod and Paula R. Williamson

The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma

Late-onset asthma (LOA) is beginning to account for an increasing proportion of asthma patients, which is often underdiagnosed in the elderly. Studies on the possible relations between aging-related genes and ...

Authors: Lin Yuan, Leyuan Wang, Xizi Du, Ling Qin, Ming Yang, Kai Zhou, Mengping Wu, Yu Yang, Zhiyuan Zheng, Yang Xiang, Xiangping Qu, Huijun Liu, Xiaoqun Qin and Chi Liu

A continuous data driven translational model to evaluate effectiveness of population-level health interventions: case study, smoking ban in public places on hospital admissions for acute coronary events

An important task in developing accurate public health intervention evaluation methods based on historical interrupted time series (ITS) records is to determine the exact lag time between pre- and post-interve...

Authors: Hossein Bonakdari, Jean-Pierre Pelletier and Johanne Martel-Pelletier

Comparing COVID-19-linked neurological complications with other viral infections

Authors: Xiao Deng, Yew-Long Lo and Eng -King Tan

Respiratory microbiome profiles differ by recent hospitalization and nursing home residence in patients on mechanical ventilation

Healthcare-associated pneumonia (HCAP) is a heterogeneous disease. We redefined nursing-home- and hospital-associated infections (NHAI) group by revising existing HCAP risk factors. The NHAI group comprised nu...

Authors: Min-gyung Baek, Seong Ji Woo, Nam Eun Kim, Chaeyun Baek, Sungho Won, Youngmi Kim, Jae Jun Lee, Hana Yi and Ji Young Hong

Exploration of predictive and prognostic alternative splicing signatures in lung adenocarcinoma using machine learning methods

Alternative splicing (AS) plays critical roles in generating protein diversity and complexity. Dysregulation of AS underlies the initiation and progression of tumors. Machine learning approaches have emerged a...

Authors: Qidong Cai, Boxue He, Pengfei Zhang, Zhenyu Zhao, Xiong Peng, Yuqian Zhang, Hui Xie and Xiang Wang

Predicting 30-days mortality for MIMIC-III patients with sepsis-3: a machine learning approach using XGboost

Sepsis is a significant cause of mortality in-hospital, especially in ICU patients. Early prediction of sepsis is essential, as prompt and appropriate treatment can improve survival outcomes. Machine learning ...

Authors: Nianzong Hou, Mingzhe Li, Lu He, Bing Xie, Lin Wang, Rumin Zhang, Yong Yu, Xiaodong Sun, Zhengsheng Pan and Kai Wang

Risk factors for severe COVID-19 in middle-aged patients without comorbidities: a multicentre retrospective study

Information regarding characteristics and risk factors of COVID-19 amongst middle-aged (40–59 years) patients without comorbidities is scarce.

Authors: Peng Wang, Jing Sha, Mei Meng, Cuiyan Wang, Qingchun Yao, Zhongfa Zhang, Wenqing Sun, Xingguang Wang, Guoqiang Qie, Xue Bai, Keke Liu and Yufeng Chu

Association of carbamylated high-density lipoprotein with coronary artery disease in type 2 diabetes mellitus: carbamylated high-density lipoprotein of patients promotes monocyte adhesion

Increasing evidence showed that carbamylated lipoprotein accelerated atherosclerosis. However, whether such modification of high-density lipoprotein (HDL) particles alters in type 2 diabetes mellitus (T2DM) pa...

Authors: Zhongli Chen, Song Ding, Yan Ping Wang, Liang Chen, Jing Yan Mao, Ying Yang, Jia Teng Sun and Ke Yang

Plasma exosome-derived microRNAs expression profiling and bioinformatics analysis under cross-talk between increased low-density lipoprotein cholesterol level and ATP-sensitive potassium channels variant rs1799858

Exosome-derived microRNAs (exo-miRs) as messengers play important roles, in the cross-talk between genetic [ATP-sensitive potassium channels (KATP) genetic variant rs1799858] and environmental [elevated serum low...

Authors: Cheng Liu, Yanxian Lai, Songsong Ying, Junfang Zhan and Yan Shen

Intra-erythrocytes magnesium deficiency could reflect cognitive impairment status due to vascular disease: a pilot study

Magnesium is a fundamental cation that regulates neuronal transmission, protein synthesis, energy metabolism. Magnesium deficiency mostly affects nervous and cardiovascular systems determining weakness, tremor...

Authors: Clementina Sitzia, Michele Sterlicchio, Calogero Crapanzano, Elena Dozio, Elena Vianello and Massimiliano Marco Corsi Romanelli

The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome

Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting...

Authors: Mathieu Blot, Jean-Baptiste Bour, Jean Pierre Quenot, Abderrahmane Bourredjem, Maxime Nguyen, Julien Guy, Serge Monier, Marjolaine Georges, Audrey Large, Auguste Dargent, Alexandre Guilhem, Suzanne Mouries-Martin, Jeremy Barben, Belaid Bouhemad, Pierre-Emmanuel Charles, Pascal Chavanet…

Regulatory T cells mediated immunomodulation during asthma: a therapeutic standpoint

Asthma is an inflammatory disease of the lung airway network, which is initiated and perpetuated by allergen-specific CD4⁺ T cells, IgE antibodies, and a massive release of Th2 cytokines. The most common clinical...

Authors: Mohammad Afzal Khan

A machine learning-based clinical tool for diagnosing myopathy using multi-cohort microarray expression profiles

Myopathies are a heterogenous collection of disorders characterized by dysfunction of skeletal muscle. In practice, myopathies are frequently encountered by physicians and precise diagnosis remains a challenge...

Authors: Andrew Tran, Chris J. Walsh, Jane Batt, Claudia C. dos Santos and Pingzhao Hu

LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC

Dysregulation of transcription and cytokine expression has been implicated in the pathogenesis of a variety inflammatory diseases. The resulting imbalance between inflammatory and resolving transcriptional pro...

Authors: Gregory Thomas, Elizabeth Frederick, Lisa Thompson, Raphael Bar-Or, Yetti Mulugeta, Melissa Hausburg, Michael Roshon, Charles Mains and David Bar-Or