Articles

Development and validation of a robust immune-related prognostic signature in early-stage lung adenocarcinoma

The incidence of stage I and stage II lung adenocarcinoma (LUAD) is likely to increase with the introduction of annual screening programs for high-risk individuals. We aimed to identify a reliable prognostic s...

Authors: Pancheng Wu, Yi Zheng, Yanyu Wang, Yadong Wang and Naixin Liang

Changes in lipid composition associated with electronic cigarette use

Electronic cigarette use is on the rise despite a number of reports linking electronic cigarettes with adverse health outcomes. Recent studies have suggested that alterations in lipid signaling may be one mech...

Authors: Holly R. Middlekauff, Kevin J. William, Baolong Su, Kacey Haptonstall, Jesus A. Araujo, Xiaohui Wu, Jason Kim and Tamer Sallam

Profiling pro-neural to mesenchymal transition identifies a lncRNA signature in glioma

Molecular classification has laid the framework for exploring glioma biology and treatment strategies. Pro-neural to mesenchymal transition (PMT) of glioma is known to be associated with aggressive phenotypes,...

Authors: Qingyu Liang, Gefei Guan, Xue Li, Chunmi Wei, Jianqi Wu, Peng Cheng, Anhua Wu and Wen Cheng

Novel single-domain antibodies against the EGFR domain III epitope exhibit the anti-tumor effect

Monoclonal antibodies (mAbs) have been used for cancer therapy. They are large and have some disadvantages limiting their use. Smaller antibody fragments are needed as their alternatives. A fully human single-...

Authors: Tao Chen, Xue Liu, Haifeng Hong and Henry Wei

RepCOOL: computational drug repositioning via integrating heterogeneous biological networks

It often takes more than 10 years and costs more than 1 billion dollars to develop a new drug for a particular disease and bring it to the market. Drug repositioning can significantly reduce costs and time in ...

Authors: Ghazale Fahimian, Javad Zahiri, Seyed Shahriar Arab and Reza H. Sajedi

Cannabis, a cause for anxiety? A critical appraisal of the anxiogenic and anxiolytic properties

Cannabis has been documented for use in alleviating anxiety. However, certain research has also shown that it can produce feelings of anxiety, panic, paranoia and psychosis. In humans, Δ⁹-tetrahydrocannabinol (TH...

Authors: Lara Sharpe, Justin Sinclair, Andrew Kramer, Michael de Manincor and Jerome Sarris

Prognostic utility of lipoprotein(a) combined with fibrinogen in patients with stable coronary artery disease: a prospective, large cohort study

Elevated lipoprotein(a) [Lp(a)] and fibrinogen (Fib) are both associated with coronary artery disease (CAD). The atherogenicity of Lp(a) can be partly due to the potentially antifibrinolytic categories. We hyp...

Authors: Yan Zhang, Jing-Lu Jin, Ye-Xuan Cao, Hui-Hui Liu, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Ying Gao, Qi Hua, Yan-Fang Li, Rui-Xia Xu, Chuan-Jue Cui, Geng Liu, Qian Dong, Jing Sun and Jian-Jun Li

Correction to: Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance

An amendment to this paper has been published and can be accessed via the original article.

Authors: Qiuyan Guo, Xia Mao, Yanqiong Zhang, Shuqin Meng, Yue Xi, Yi Ding, Xiaocun Zhang, Yuntao Dai, Xia Liu, Chao Wang, Yuting Li and Na Lin

Characterization of the expression and immunological impact of the transcriptional activator CREB in renal cell carcinoma

The non-classical human leukocyte antigen (HLA)-G is a strong immunomodulatory molecule. Under physiological conditions, HLA-G induces immunological tolerance in immune privileged tissues, while under pathophy...

Authors: Michael Friedrich, Christine Stoehr, Simon Jasinski-Bergner, Arndt Hartmann, Sven Wach, Bernd Wullich, André Steven and Barbara Seliger

The study of the association between immune monitoring and pneumonia in kidney transplant recipients through machine learning models

Kidney transplantation is the optimal treatment to cure the patients with end-stage renal disease (ESRD). However, the infectious complication, especially pneumonia, is the main cause of mortality in the early...

Authors: Bo Peng, Hang Gong, Han Tian, Quan Zhuang, Junhui Li, Ke Cheng and Yingzi Ming

Credible practice of modeling and simulation in healthcare: ten rules from a multidisciplinary perspective

The complexities of modern biomedicine are rapidly increasing. Thus, modeling and simulation have become increasingly important as a strategy to understand and predict the trajectory of pathophysiology, diseas...

Authors: Ahmet Erdemir, Lealem Mulugeta, Joy P. Ku, Andrew Drach, Marc Horner, Tina M. Morrison, Grace C. Y. Peng, Rajanikanth Vadigepalli, William W. Lytton and Jerry G. Myers Jr.

Correction to: Clinical characterization, genetic profiling, and immune infiltration of TOX in diffuse gliomas

An amendment to this paper has been published and can be accessed via the original article.

Authors: Hao Zhang, Fan Fan, Yuanqiang Yu, Zeyu Wang, Fangkun Liu, Ziyu Dai, Liyang Zhang, Zhixiong Liu and Quan Cheng

Mitochondrial donation in translational medicine; from imagination to reality

The existence of active crosstalk between cells in a paracrine and juxtacrine manner dictates specific activity under physiological and pathological conditions. Upon juxtacrine interaction between the cells, v...

Authors: Hesam Saghaei Bagheri, Farhad Bani, Savas Tasoglu, Amir Zarebkohan, Reza Rahbarghazi and Emel Sokullu

Metabolic profiling of pre-gestational and gestational diabetes mellitus identifies novel predictors of pre-term delivery

Pregnant women with gestational diabetes mellitus (GDM) or type 2 diabetes mellitus (T2DM) are at increased risks of pre-term labor, hypertension and preeclampsia. In this study, metabolic profiling of blood s...

Authors: Ilhame Diboun, Manjunath Ramanjaneya, Yasser Majeed, Lina Ahmed, Mohammed Bashir, Alexandra E. Butler, Abdul Badi Abou-Samra, Stephen L. Atkin, Nayef A. Mazloum and Mohamed A. Elrayess

A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a serious and complex physical illness that affects all body systems with a multiplicity of symptoms, but key hallmarks of the disease are pervasi...

Authors: Eiren Sweetman, Torsten Kleffmann, Christina Edgar, Michel de Lange, Rosamund Vallings and Warren Tate

Translational cancer biology

Authors: Cristina Maccalli

Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKɛ complex inhibitor BX795

Adoptive transfer of engineered immune cells is a promising strategy for cancer treatment. However, low transduction efficiency particularly when large payload lentiviral vectors are used on primary T cells is...

Authors: Lingyu Li, Yuan Gao, Richa Srivastava, Wei Wang, Qinghui Xiong, Zhiming Fang, Alejandra Pelayo, Carolyn Denson, Angshumala Goswami, Rona Harari-Steinfeld, Zhifen Yang, Lihong Weng, Lei Stanley Qi and Francesco M. Marincola

A persistently replicating SARS-CoV-2 variant derived from an asymptomatic individual

Since the first outbreak of SARS-CoV-2, the clinical characteristics of the Coronavirus Disease 2019 (COVID-19) have been progressively changed. Data reporting a viral intra-host and inter-host evolution favou...

Authors: Francesca Caccuri, Alberto Zani, Serena Messali, Marta Giovanetti, Antonella Bugatti, Giovanni Campisi, Federica Filippini, Erika Scaltriti, Massimo Ciccozzi, Simona Fiorentini and Arnaldo Caruso

Synergic effects of decellularized bone matrix, hydroxyapatite, and extracellular vesicles on repairing of the rabbit mandibular bone defect model

Extracellular vesicles (ECV) and bone extracellular matrix (ECM) have beneficial effects on the treatment of some pathological conditions. The purpose of this study was to find the synergic effects of decellul...

Authors: Asrin Emami, Tahereh Talaei-Khozani, Saeid Tavanafar, Nehleh Zareifard, Negar Azarpira and Zahra Vojdani

Development and validation of a cancer stem cell-related signature for prognostic prediction in pancreatic ductal adenocarcinoma

Cancer stem cells (CSCs) are crucial to the malignant behaviour and poor prognosis of pancreatic ductal adenocarcinoma (PDAC). In recent years, CSC biology has been widely studied, but practical prognostic sig...

Authors: Zengyu Feng, Minmin Shi, Kexian Li, Yang Ma, Lingxi Jiang, Hao Chen and Chenghong Peng

The use of mesenchymal stromal cells in the treatment of coronavirus disease 2019

More than seven months into the coronavirus disease -19 (COVID-19) pandemic, infection from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over 21.2 million cases and resulted in o...

Authors: Maurice A. Canham, John D. M. Campbell and Joanne C. Mountford

Transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to animals: an updated review

COVID-19 caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan (Hubei province, China) during late 2019. It has spread across the globe affecting nearly 21 million ...

Authors: Sina Salajegheh Tazerji, Phelipe Magalhães Duarte, Parastoo Rahimi, Fatemeh Shahabinejad, Santosh Dhakal, Yashpal Singh Malik, Awad A. Shehata, Juan Lama, Jörn Klein, Muhammad Safdar, Md. Tanvir Rahman, Krzysztof J. Filipiak, Alfonso J. Rodríguez-Morales, Md. Abdus Sobur, Farrokhreza Kabir, Bita Vazir…

Down-regulation of PADI2 prevents proliferation and epithelial-mesenchymal transition in ovarian cancer through inhibiting JAK2/STAT3 pathway in vitro and in vivo, alone or in combination with Olaparib

Epithelial ovarian cancer (EOC) is the most lethal disease among female genital malignant tumors. Peptidylarginine deiminase type II(PADI II) has been shown to enhance a variety of cancers carcinogenesis, incl...

Authors: Lidong Liu, Zhiwei Zhang, Guoxiang Zhang, Ting Wang, Yingchun Ma and Wei Guo

Phase II multicenter randomized controlled clinical trial on the efficacy of intra-articular injection of autologous bone marrow mesenchymal stem cells with platelet rich plasma for the treatment of knee osteoarthritis

Mesenchymal stromal cells are a safe and promising option to treat knee osteoarthritis as previously demonstrated in different clinical trials. However, their efficacy, optimal dose and addition of adjuvants m...

Authors: José María Lamo-Espinosa, Juan F. Blanco, Mikel Sánchez, Victoria Moreno, Froilán Granero-Moltó, Fermín Sánchez-Guijo, Íñigo Crespo-Cullel, Gonzalo Mora, Diego Delgado San Vicente, Orlando Pompei-Fernández, Jesús Dámaso Aquerreta, Jorge María Núñez-Córdoba, María Vitoria Sola, Andrés Valentí-Azcárate, Enrique J. Andreu, María del Consuelo del Cañizo…

Expression profile of SYNE3 and bioinformatic analysis of its prognostic value and functions in tumors

Spectrin repeat containing nuclear envelope family member 3 (SYNE3) encodes an essential component of the linker of the cytoskeleton and nucleoskeleton (LINC) complex, namely nesprin-3. In a tumor, invasivenes...

Authors: Liwei Liao, Longshan Zhang, Mi Yang, Xiaoqing Wang, Weiqiang Huang, Xixi Wu, Hua Pan, Lu Yuan, Wenqi Huang, Yuting Wu and Jian Guan

Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection

Severe COVID-19 infection results in a systemic inflammatory response (SIRS). This SIRS response shares similarities to the changes observed during the peri-operative period that are recognised to be associate...

Authors: Donogh Maguire, Marylynne Woods, Conor Richards, Ross Dolan, Jesse Wilson Veitch, Wei M. J. Sim, Olivia E. H. Kemmett, David C. Milton, Sophie L. W. Randall, Ly D. Bui, Nicola Goldmann, Allan Cameron, Barry Laird, Dinesh Talwar, Ian Godber, Alan Davidson…

Pathophysiology and treatment strategies for COVID-19

The outbreak of Coronavirus disease of 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), has posed a serious health threat. The increasing number of COVID-19 cases aro...

Authors: Manoj Kumar and Souhaila Al Khodor

Correlation of the two most frequent HLA haplotypes in the Italian population to the differential regional incidence of Covid-19

Understanding how HLA polymorphisms may affect both susceptibility, course and severity of Covid-19 infection could help both at the clinical level to identify individuals at higher risk from the disease and a...

Authors: Simona Pisanti, Joris Deelen, Anna Maria Gallina, Mariella Caputo, Marianna Citro, Mario Abate, Nicoletta Sacchi, Carmine Vecchione and Rosanna Martinelli

Human platelet lysate to substitute fetal bovine serum in hMSC expansion for translational applications: a systematic review

Foetal bovine serum (FBS), is the most commonly used culture medium additive for in vitro cultures, despite its undefined composition, its potential immunogenicity and possible prion/zoonotic transmission. For...

Authors: M. Guiotto, W. Raffoul, A. M. Hart, M. O. Riehle and P. G. di Summa

A phase 2 study of combined chemo-immunotherapy with cisplatin-pembrolizumab and radiation for unresectable vulvar squamous cell carcinoma

Unresectable or metastatic vulvar cancer has relatively poor outcomes despite chemotherapy-sensitized radiation therapy and combination cytotoxic therapy. Despite the virus-associated and immunogenic nature of...

Authors: Oladapo Yeku, Andrea L. Russo, Hang Lee and David Spriggs

Impact of different omega-3 fatty acid sources on lipid, hormonal, blood glucose, weight gain and histopathological damages profile in PCOS rat model

Omega-3 fatty acids (Ω-3 PUFAs) may help to improve health status in polycystic ovarian syndrome (PCOS) by reducing numerous metabolic disorders (insulin sensitivity, hyperinsulinemia, lipid profile, obesity a...

Authors: Fiza Komal, Muhammad Kamran Khan, Muhammad Imran, Muhammad Haseeb Ahmad, Haseeb Anwar, Usman Ali Ashfaq, Nazir Ahmad, Amna Masroor, Rabia Shabir Ahmad, Muhammad Nadeem and Mahr Un Nisa

Toward a hemorrhagic trauma severity score: fusing five physiological biomarkers

To introduce the Hemorrhage Intensive Severity and Survivability (HISS) score, based on the fusion of multi-biomarker data; glucose, lactate, pH, potassium, and oxygen tension, to serve as a patient-specific a...

Authors: Ankita Bhat, Daria Podstawczyk, Brandon K. Walther, John R. Aggas, David Machado-Aranda, Kevin R. Ward and Anthony Guiseppi-Elie

Prediction of drug-target interactions from multi-molecular network based on LINE network representation method

The prediction of potential drug-target interactions (DTIs) not only provides a better comprehension of biological processes but also is critical for identifying new drugs. However, due to the disadvantages of...

Authors: Bo-Ya Ji, Zhu-Hong You, Han-Jing Jiang, Zhen-Hao Guo and Kai Zheng

Perspectives in melanoma: meeting report from the “Melanoma Bridge” (December 5th–7th, 2019, Naples, Italy)

The melanoma treatment landscape changed in 2011 with the approval of the first anti-cytotoxic T-lymphocyte-associated protein (CTLA)-4 checkpoint inhibitor and of the first BRAF-targeted monoclonal antibody, ...

Authors: Paolo A. Ascierto, Igor Puzanov, Sanjiv S. Agarwala, Christian Blank, Richard D. Carvajal, Sandra Demaria, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Patrick Hwu, Roger S. Lo, Georgina V. Long, Jason J. Luke…

Mathematical models for devising the optimal SARS-CoV-2 strategy for eradication in China, South Korea, and Italy

Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spreads rapidly and has attracted worldwide attention.

Authors: Shuo Jiang, Qiuyue Li, Chaoqun Li, Shanshan Liu, Xiaomeng He, Tao Wang, Hua Li, Christopher Corpe, Xiaoyan Zhang, Jianqing Xu and Jin Wang

Sugar-sweetened beverages increases the risk of hypertension among children and adolescence: a systematic review and dose–response meta-analysis

In the current systematic review and meta-analysis, we summarized the studies that evaluated the effects of sugar-sweetened beverages (SSBs) intake on blood pressure among children and adolescents.

Authors: Mahdieh Abbasalizad Farhangi, Leila Nikniaz and Mahdieh Khodarahmi

Mass spectrometry-based analysis of formalin-fixed, paraffin-embedded distal cholangiocarcinoma identifies stromal thrombospondin-2 as a potential prognostic marker

Distal cholangiocarcinoma is an aggressive malignancy with a dismal prognosis. Diagnostic and prognostic biomarkers for distal cholangiocarcinoma are lacking. The aim of the present study was to identify diffe...

Authors: Johannes Byrling, Theresa Kristl, Dingyuan Hu, Indira Pla, Aniel Sanchez, Agata Sasor, Roland Andersson, György Marko-Varga and Bodil Andersson

A hypoxia-related signature for clinically predicting diagnosis, prognosis and immune microenvironment of hepatocellular carcinoma patients

Hypoxia plays an indispensable role in the development of hepatocellular carcinoma (HCC). However, there are few studies on the application of hypoxia molecules in the prognosis predicting of HCC. We aim to id...

Authors: Baohui Zhang, Bufu Tang, Jianyao Gao, Jiatong Li, Lingming Kong and Ling Qin

Tissue expression of lactate transporters (MCT1 and MCT4) and prognosis of malignant pleural mesothelioma (brief report)

Malignant pleural mesothelioma (MPM) is an aggressive neoplasm of the pleura, mainly related to asbestos exposure. As in other solid tumors, malignant cells exhibit high glucose uptake and glycolytic rates wit...

Authors: Irene Dell’Anno, Elisa Barone, Luciano Mutti, Doris M. Rassl, Stefan J. Marciniak, Roberto Silvestri, Stefano Landi and Federica Gemignani

Immune infiltrating cells in duodenal cancers

Duodenal adenocarcinoma (DA) is a rare yet aggressive malignancy, with increasing incidence in the last decades. Its low frequency has hampered a thorough understanding of the pathogenesis of the disease and o...

Authors: G. Donisi, G. Capretti, N. Cortese, A. Rigamonti, F. Gavazzi, G. Nappo, A. Pulvirenti, M. Sollai, P. Spaggiari, A. Zerbi and F. Marchesi

Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML

The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early drivers of myelodysplastic syndromes (MDS) and acute m...

Authors: James S. Smith, Katrina M. Lappin, Stephanie G. Craig, Fabio G. Liberante, Clare M. Crean, Simon S. McDade, Alexander Thompson, Ken I. Mills and Kienan I. Savage

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the first coronavirus disease 2019 (COVID-19) outbreak in China and has become a public health emergency of international concern. SARS-CoV-2 outbrea...

Authors: Maria Pachetti, Bruna Marini, Fabiola Giudici, Francesca Benedetti, Silvia Angeletti, Massimo Ciccozzi, Claudio Masciovecchio, Rudy Ippodrino and Davide Zella

Comprehensive profiling of immune-related genes in soft tissue sarcoma patients

Immune-related genes (IRGs) have been confirmed to have an important role in tumorigenesis and tumor microenvironment formation. Nevertheless, a systematic analysis of IRGs and their clinical significance in s...

Authors: Chuan Hu, Bo Chen, Zhangheng Huang, Chuan Liu, Lin Ye, Cailin Wang, Yuexin Tong, Jiaxin Yang and Chengliang Zhao

Mesenchymal stem cell mediates cardiac repair through autocrine, paracrine and endocrine axes

In the past decade, despite key advances in therapeutic strategies following myocardial infarction, none can directly address the loss of cardiomyocytes following ischemic injury. Cardiac cell-based therapy is...

Authors: Celia Sid-Otmane, Louis P. Perrault and Hung Q. Ly

Neuroimaging characteristics of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review

Since the 1990s, neuroimaging has been utilised to study Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating illness with unknown aetiology. While brain abnormalities in ME/CFS have bee...

Authors: Zack Y. Shan, Leighton R. Barnden, Richard A. Kwiatek, Sandeep Bhuta, Daniel F. Hermens and Jim Lagopoulos

High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients

African American women experience a twofold higher incidence of triple-negative breast cancer (TNBC) and are 40% more likely to die from breast cancer than women of other ethnicities. However, the molecular ba...

Authors: Xuan Yang, Mohamed Amgad, Lee A. D. Cooper, Yuhong Du, Haian Fu and Andrey A. Ivanov

Letter to the Editor: No immunophenotyping in peripheral blood of prostate cancer patients treated with neoadjuvant Rituximab?

Authors: Paulius Bosas, Gintaras Zaleskis, Vita Pasukoniene and Feliksas Jankevicius

MiR-199a-3p/5p participated in TGF-β and EGF induced EMT by targeting DUSP5/MAP3K11 in pterygium

Recently, it has been reported that miRNA is involved in pterygium, however the exact underlying mechanism in pterygium is unrevealed and require further investigation.

Authors: Siying He, Yifang Huang, Shiqi Dong, Chen Qiao, Guohua Yang, Shuai Zhang, Chen Wang, Yuting Xu, Fang Zheng and Ming Yan

Identification and validation of stemness-related lncRNA prognostic signature for breast cancer

Long noncoding RNAs (lncRNAs) are emerging as crucial contributors to the development of breast cancer and are involved in the stemness regulation of breast cancer stem cells (BCSCs). LncRNAs are closely assoc...

Authors: Xiaoying Li, Yang Li, Xinmiao Yu and Feng Jin

Emerging of a SARS-CoV-2 viral strain with a deletion in nsp1

The new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which was first detected in Wuhan (China) in December of 2019 is responsible for the current global pandemic. Phylogenetic analysis reveale...

Authors: Francesca Benedetti, Greg A. Snyder, Marta Giovanetti, Silvia Angeletti, Robert C. Gallo, Massimo Ciccozzi and Davide Zella