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  1. Inactivaion of tumor suppressor genes (TSGs) by promoter CpG methylation frequently occurs in tumorigenesis, even in the early stages, contributing to the initiation and progression of human cancers. Deleted in l...

    Authors: Zhaohui Wang, Lili Li, Xianwei Su, Zifen Gao, Gopesh Srivastava, Paul G Murray, Richard Ambinder and Qian Tao
    Citation: Journal of Translational Medicine 2012 10:209
  2. Splenectomy is the most effective treatment for patients with primary immune thrombocytopenia (ITP) who fail to respond to steroid therapy. Thus far, there is no effective means to predict the long-term haemat...

    Authors: Chao-Xu Zheng, Zhuang-Qi Ji, Long-Juan Zhang, Qiong Wen, Liu-Hua Chen, Jun-Feng Yu and Dong Zheng
    Citation: Journal of Translational Medicine 2012 10:208
  3. Endometrial regenerative cells (ERC) and bone marrow stromal cells (BMSC) are being used in clinical trials. While they have been reported to have similar characteristics, they have not been directly compared.

    Authors: Huan Wang, Ping Jin, Marianna Sabatino, Jiaqiang Ren, Sara Civini, Vladimir Bogin, Thomas E Ichim and David F Stroncek
    Citation: Journal of Translational Medicine 2012 10:207
  4. High endothelial venules (HEV) have been recognized to play a role in metastasis by its changes seen in the cancer microenvironment of lymph nodes (LN) and solid cancers. Squamous cell carcinoma (SCC) of the t...

    Authors: Ser Yee Lee, Chao-Nan Qian, Aik Seng Ooi, Peiyi Chen, Hui Min Bernice Wong, Swe Swe Myint, Jing Chii Wong, Siok Gek Jacqueline Hwang and Khee Chee Soo
    Citation: Journal of Translational Medicine 2012 10:206
  5. Prediction of clinical outcome in cancer is usually achieved by histopathological evaluation of tissue samples obtained during surgical resection of the primary tumor. Traditional tumor staging (AJCC/UICC-TNM ...

    Authors: Jérôme Galon, Franck Pagès, Francesco M Marincola, Helen K Angell, Magdalena Thurin, Alessandro Lugli, Inti Zlobec, Anne Berger, Carlo Bifulco, Gerardo Botti, Fabiana Tatangelo, Cedrik M Britten, Sebastian Kreiter, Lotfi Chouchane, Paolo Delrio, Hartmann Arndt…
    Citation: Journal of Translational Medicine 2012 10:205
  6. The concept of tissue banking as a “bio-repository” aimed to collection, storing and distribution of human biological material and clinical information, is emerging as a successful strategy to support clinical...

    Authors: Gerardo Botti, Renato Franco, Monica Cantile, Gennaro Ciliberto and Paolo Antonio Ascierto
    Citation: Journal of Translational Medicine 2012 10:204
  7. Helium inhalation protects myocardium, brain and endothelium against ischemia/reperfusion injury in animals and humans, when applied according to specific “conditioning” protocols. Before widespread use of thi...

    Authors: Gezina TML Oei, Kirsten F Smit, Djai vd Vondervoort, Daniel Brevoord, Arjan Hoogendijk, Catharina W Wieland, Markus W Hollmann, Benedikt Preckel and Nina C Weber
    Citation: Journal of Translational Medicine 2012 10:201
  8. Fork head box M1 (FoxM1) is a proliferation-associated transcription factor essential for cell cycle progression. Numerous studies have documented that FoxM1 has multiple functions in tumorigenesis and its ele...

    Authors: Yi-Jun Xue, Ri-Hai Xiao, Da-Zhi Long, Xiao-Feng Zou, Xiao-Ning Wang, Guo-Xi Zhang, Yuan-Hu Yuan, Geng-Qing Wu, Jun Yang, Yu-Ting Wu, Hui Xu, Fo-Lin Liu and Min Liu
    Citation: Journal of Translational Medicine 2012 10:200
  9. Glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49) deficiency is caused by one or more mutations in the G6PD gene on chromosome X. An association between enzyme levels and gene haplotypes remains to be establi...

    Authors: Ashraf Dallol, Huda Banni, Mamdooh A Gari, Mohammed H Al-Qahtani, Adel M Abuzenadeh, Fatin Al-Sayes, Adeel G Chaudhary, Jeffrey Bidwell and Wael Kafienah
    Citation: Journal of Translational Medicine 2012 10:199
  10. Drug repurposing for cancer treatment is an emerging approach to discover clinically approved drugs that demonstrate antineoplastic effect. The effective therapeutics for patients with advanced adrenocortical ...

    Authors: Naris Nilubol, Lisa Zhang, Min Shen, Ya-Qin Zhang, Mei He, Christopher P Austin and Electron Kebebew
    Citation: Journal of Translational Medicine 2012 10:198
  11. The purpose of this study is to evaluate the predictive significance of preoperative serum level of cytokeratin 19 fragments (Cyfra21-1) and squamous cell carcinoma antigen (SCC-Ag) after complete resection in...

    Authors: Xun Cao, Lin Zhang, Gui-Rong Feng, Juan Yang, Ruo-Yan Wang, Jun Li, Xiao-Min Zheng and Yu-Jing Han
    Citation: Journal of Translational Medicine 2012 10:197
  12. Embryonic stem cells (ESCs) are pluripotent stem cells and can form tumors containing cells from all three germ layers. Similarities between pluripotent stem cells and malignant tumor cells have been identifie...

    Authors: Xinrong Peng, Tao Liu, Ying Wang, Qiaoling Yan, Huajun Jin, Linfang Li, Qijun Qian and Mengchao Wu
    Citation: Journal of Translational Medicine 2012 10:196
  13. Rheumatoid arthritis is a disease affecting the extracellular matrix of especially synovial joints. The thickness of the synovial membrane increases and surrounding tissue degrades, leading to altered collagen...

    Authors: Anne Sofie Siebuhr, Jianxia Wang, Morten Karsdal, Anne-C Bay-Jensen, Jin Y and Zheng Q
    Citation: Journal of Translational Medicine 2012 10:195
  14. Catheter-associated urinary tract infection (CAUTI) is a common nosocomial device-associated infection. It is now recognized that the high infection rates were caused by the formation of biofilm on the surface...

    Authors: Wei He, Dongmin Wang, Zhangqun Ye, Weihong Qian, Yan Tao, Xiaofeng Shi, Ling Liu, Jin Chen, Ling Qiu, Peng Wan, Xiaojun Jia, Xia Li, Caixia Gao, Xuexia Ma, Biyan Wen, Nianzhen Chen…
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S14

    This article is part of a Supplement: Volume 10 Supplement 1

  15. Minimally invasive video-assisted thyroidectomy (MIVAT), the modified Miccoli’s thyroid surgery, is the most widespread minimally invasive technique and has been widely used for treatment of thyroid disease. T...

    Authors: Jian-jun Yu, Shan-lin Bao, Sheng-lin Yu, Da-Qing Zhang, Wings TY Loo, Louis WC Chow, Li Su, Zhen Cui, Kai Chen, Li-Qiong Ma, Ning Zhang, Hui Yu, Yun-Zhen Yang, Yu Dong, Adrian YS Yip and Elizabeth LY Ng
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S13

    This article is part of a Supplement: Volume 10 Supplement 1

  16. Chinese herbal medicine is increasingly widely used as a complementary approach for control of breast cancer recurrence and metastasis. In this paper, we examined the implicit prescription patterns behind the ...

    Authors: Yanhua He, Xiao Zheng, Cindy Sit, Wings TY Loo, ZhiYu Wang, Ting Xie, Bo Jia, Qiaobo Ye, Kamchuen Tsui, Louis WC Chow and Jianping Chen
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S12

    This article is part of a Supplement: Volume 10 Supplement 1

  17. Plasma cell mastitis is distinct from the common form of mastitis and clinically resembles breast carcinoma. The lesion occurs in non-lactating young women, and the incidence rate is rising. Surgical resection...

    Authors: Jian-jun Yu, Shan-lin Bao, Sheng-lin Yu, Da-Qing Zhang, Wings TY Loo, Louis WC Chow, Li Su, Zhen Cui, Kai Chen, Li-Qiong Ma, Ning Zhang, Hui Yu, Yun-Zhen Yang, Yu Dong, Adrian YS Yip and Elizabeth LY Ng
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S11

    This article is part of a Supplement: Volume 10 Supplement 1

  18. Breast cancer is a heterogeneous disease in terms of transcriptional aberrations; moreover, microarray gene expression profiles had defined 5 molecular subtypes based on certain intrinsic genes. This study aim...

    Authors: Chi-Cheng Huang, Shih-Hsin Tu, Heng-Hui Lien, Jaan-Yeh Jeng, Jung-Sen Liu, Ching-Shui Huang, Yih-Yiing Wu, Chih-Yi Liu, Liang-Chuan Lai and Eric Y Chuang
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S10

    This article is part of a Supplement: Volume 10 Supplement 1

  19. Periodontitis is a common disease that affects the periodontal tissue supporting the teeth. This disease is attributed to multiple risk factors, including diabetes, cigarette smoking, alcohol, pathogenic micro...

    Authors: Wings TY Loo, Lan-jun Bai, Chang-bin Fan, Yuan Yue, Yi-ding Dou, Min Wang, Hao Liang, Mary NB Cheung, Louis WC Chow, Jin-le Li, Ye Tian and Liu Qing
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S9

    This article is part of a Supplement: Volume 10 Supplement 1

  20. Periodontal disease is thought to arise from the interaction of various factors, including the susceptibility of the host, the presence of pathogenic organisms, and the absence of beneficial species. The genet...

    Authors: Wings TY Loo, Chang-bin Fan, Lan-jun Bai, Yuan Yue, Yi-ding Dou, Min Wang, Hao Liang, Mary NB Cheung, Louis WC Chow, Jin-le Li, Ye Tian and Liu Qing
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S8

    This article is part of a Supplement: Volume 10 Supplement 1

  21. Multi-drug resistance to chemotherapeutic agents is a major cause of treatment failure in breast cancer. In this study, we investigated the effects of emodin on reversing the multi-drug resistance, examined th...

    Authors: Jian-min Fu, Jie Zhou, Jian Shi, Jian-sheng Xie, Li Huang, Adrian YS Yip, Wings TY Loo, Louis WC Chow and Elizabeth LY Ng
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S7

    This article is part of a Supplement: Volume 10 Supplement 1

  22. Axillary node staging plays an important role in the prognostic evaluation and planning of adjuvant treatment. Breast cancer stem cells, identified on the basis of CD44+CD24-/low expression, are associated with m...

    Authors: Wei Wei, Hui Hu, Haosheng Tan, Louis WC Chow, Adrian YS Yip and Wings TY Loo
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S6

    This article is part of a Supplement: Volume 10 Supplement 1

  23. Chronic periodontitis (CP) is a chronic inflammation associated with elevations of several inflammatory and cardiac markers. Studies implicated CP as one of the etiologies in coronary heart disease (CHD). Card...

    Authors: Wings TY Loo, Yuan Yue, Chang-bin Fan, Lan-jun Bai, Yi-ding Dou, Min Wang, Hao Liang, Mary NB Cheung, Louis WC Chow, Jin-le Li, Ye Tian and Liu Qing
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S5

    This article is part of a Supplement: Volume 10 Supplement 1

  24. Triple negative breast cancer (TNBC) occurs in approximately 10% to 25% of all patients with breast cancer and is associated with poor prognosis. Neo-adjuvant chemotherapy has been reported to produce a higher...

    Authors: Yiqing Tang, Li Zhu, Yafen Li, Jun Ji, Jianfang Li, Fei Yuan, Dengbin Wang, Weiguo Chen, Ou Huang, Xiaosong Chen, Jiayi Wu, Kunwei Shen, Wings TY Loo and Louis WC Chow
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S4

    This article is part of a Supplement: Volume 10 Supplement 1

  25. Biological molecular markers such as proto-oncogene erbB-2 (HER-2/neu, c-erbB-2), the CXC chemokine receptor 4 (CXCR4), estrogen receptor (ER), Proliferating Cell Nuclear Antigen (PCNA), DNA topoisomerase II (top...

    Authors: Shi-Xin Yang, Wings TY Loo, Louis WC Chow, Xin-hua Yang, Yi Zhan, Lin-Jun Fan, Fan Zhang, Li Chen, Qing-liang Wang, Hua-Liang Xiao, Jin-Long Wu, Xiu-wu Bian and Jun Jiang
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S3

    This article is part of a Supplement: Volume 10 Supplement 1

  26. Estrogen plays an important role in the development of estrogen-dependent breast carcinoma. Recently, several studies demonstrated a possible involvement of several micro RNAs (miRNAs) in the development of re...

    Authors: Mariko Masuda, Yasuhiro Miki, Shuko Hata, Kiyoshi Takagi, Minako Sakurai, Katsuhiko Ono, Koyu Suzuki, Yang Yang, Eriko Abe, Hisashi Hirakawa, Takanori Ishida, Takashi Suzuki, Noriaki Ohuchi and Hironobu Sasano
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S2

    This article is part of a Supplement: Volume 10 Supplement 1

  27. Tumor vasculature expresses a distinct set of molecule signatures on the endothelial cell surface different from the resting blood vessels of other organs and tissues in the body. This makes them an attractive...

    Authors: Zhi Jie Li and Chi Hin Cho
    Citation: Journal of Translational Medicine 2012 10(Suppl 1):S1

    This article is part of a Supplement: Volume 10 Supplement 1

  28. CD4+CD25+ regulatory T cells (Tregs) play an important role in maintaining immunological tolerance to self and foreign antigens. T cell receptors (TCR) reflect the composition and function of T cells. It is not u...

    Authors: Jiezuan Yang, Ping Yi, Li Wei, Zherong Xu, Yunbo Chen, Lingling Tang and Lanjuan Li
    Citation: Journal of Translational Medicine 2012 10:193
  29. Circulating melanoma cells (CMCs) are thought to be valuable in improving measures of prognosis in melanoma patients and may be a useful marker of residual disease to identify non-metastatic patients requiring...

    Authors: James B Freeman, Elin S Gray, Michael Millward, Robert Pearce and Melanie Ziman
    Citation: Journal of Translational Medicine 2012 10:192
  30. As Chronic Fatigue Syndrome (CFS) has been known to follow Epstein-Bar virus (EBV) and other systemic infections; our objective was to describe differences in immune activation in post-infective CFS (PI-CFS) p...

    Authors: Gordon Broderick, Ben Z Katz, Henrique Fernandes, Mary Ann Fletcher, Nancy Klimas, Frederick A Smith, Maurice RG O’Gorman, Suzanne D Vernon and Renee Taylor
    Citation: Journal of Translational Medicine 2012 10:191
  31. Substantial advances have been generated in understanding the pathogenesis of rheumatoid arthritis (RA). Current murine models of RA-like disease have provided great insights into the molecular mechanism of in...

    Authors: Alexander V Misharin, G Kenneth Haines III, Shawn Rose, Angelical K Gierut, Richard S Hotchkiss and Harris Perlman
    Citation: Journal of Translational Medicine 2012 10:190
  32. Telocytes, a new type of interstitial cells, have been identified in many organs in mammals. The present studies aimed at investigating the ultrastructure, distribution and interactions of telocytes with surro...

    Authors: Yonghua Zheng, Tongyu Zhu, Miao Lin, Duojiao Wu and Xiangdong Wang
    Citation: Journal of Translational Medicine 2012 10:188
  33. The additive effects of obesity and metabolic syndrome on left ventricular (LV) maladaptive remodeling and function in hypertension are not characterized.

    Authors: Dominik Linz, Mathias Hohl, Felix Mahfoud, Jan-Christian Reil, Wolfgang Linz, Thomas Hübschle, Hans-Paul Juretschke, Claudia Neumann-Häflin, Hartmut Rütten and Michael Böhm
    Citation: Journal of Translational Medicine 2012 10:187
  34. MicroRNAs are aberrantly expressed and correlate with tumourigenesis and the progression of solid tumours. The miR-200 family determines the epithelial phenotype of cancer cells and regulates invasiveness and ...

    Authors: Manuel Valladares-Ayerbes, Margarita Reboredo, Vanessa Medina-Villaamil, Pilar Iglesias-Díaz, Maria José Lorenzo-Patiño, Mar Haz, Isabel Santamarina, Moisés Blanco, Juan Fernández-Tajes, Maria Quindós, Alberto Carral, Angélica Figueroa, Luis Miguel Antón-Aparicio and Lourdes Calvo
    Citation: Journal of Translational Medicine 2012 10:186
  35. The clinical course of cutaneous melanoma (CM) can differ significantly for patients with identical stages of disease, defined clinico-pathologically, and no molecular markers differentiate patients with such ...

    Authors: Luca Sigalotti, Alessia Covre, Elisabetta Fratta, Giulia Parisi, Paolo Sonego, Francesca Colizzi, Sandra Coral, Samuele Massarut, John M Kirkwood and Michele Maio
    Citation: Journal of Translational Medicine 2012 10:185
  36. Cervical cancer is the third most common cancer in women worldwide. The most common histopathological subtype is cervical squamous cell carcinoma (SCC, 75-80%), followed by adenocarcinoma (AC) and adenosquamou...

    Authors: Vivian M Spaans, Alexander AW Peters, Gert Jan Fleuren and Ekaterina S Jordanova
    Citation: Journal of Translational Medicine 2012 10:184
  37. The transforming growth factor (TGF-β) family of growth factors controls an immense number of cellular responses and figures prominently in development and homeostasis of most human tissues. Work over the past...

    Authors: Lenka Kubiczkova, Lenka Sedlarikova, Roman Hajek and Sabina Sevcikova
    Citation: Journal of Translational Medicine 2012 10:183
  38. Inducing donor-specific tolerance in renal transplant patients could potentially prevent allograft rejection and calcineurin inhibitor nephrotoxicity. Combined kidney and hematopoietic stem cell transplant fro...

    Authors: Duojiao Wu, Guisheng Qi, Xuanchuan Wang, Ming Xu, Ruiming Rong, Xiangdong Wang and Tongyu Zhu
    Citation: Journal of Translational Medicine 2012 10:182
  39. Melanoma antigen D1 (MAGED1) is a member of the type II melanoma antigen (MAGE) family. The down-regulation of MAGED1 expression has been shown in breast carcinoma cell lines and in glioma stem cells and may p...

    Authors: Zhao-lei Zeng, Wen-jing Wu, Jing Yang, Zhen-jie Tang, Dong-liang Chen, Miao-zhen Qiu, Hui-yan Luo, Zhi-qiang Wang, Ying Jin, De-shen Wang and Rui-hua Xu
    Citation: Journal of Translational Medicine 2012 10:181

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