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  1. T-cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles (KRECs) are circular DNA segments generated in T and B cells during their maturation in the thymus and bone marrow. Th...

    Authors: Federico Serana, Marco Chiarini, Cinzia Zanotti, Alessandra Sottini, Diego Bertoli, Andrea Bosio, Luigi Caimi and Luisa Imberti
    Citation: Journal of Translational Medicine 2013 11:119
  2. Human papillomavirus type 16 (HPV 16) E2 protein is a multifunctional DNA-binding protein. HPV 16 E2 regulates many biological responses, including DNA replication, gene expression, and apoptosis. The purpose ...

    Authors: Ling-juan Gao, Ping-qing Gu, Wei Zhao, Wen-yan Ding, Xue-qing Zhao, Shu-yu Guo and Tian-ying Zhong
    Citation: Journal of Translational Medicine 2013 11:118
  3. Vasoactive intestinal peptide (VIP) exerts immune-modulatory actions mainly via VPAC1 receptor stimulation. VPAC1 may be a treatment target of inflammatory diseases, but little is known about the receptor expr...

    Authors: Angela Storka, Bernhard Burian, Gerhard Führlinger, Breanna Clive, Terri Sun, Richard Crevenna, Andrea Gsur, Wilhelm Mosgöller and Michael Wolzt
    Citation: Journal of Translational Medicine 2013 11:117
  4. Whilst advances in reperfusion therapies have reduced early mortality from acute myocardial infarction, heart failure remains a common complication, and may develop very early or long after the acute event. Re...

    Authors: Nishat Siddiqi, Margaret Bruce, Christopher J Neil, Baljit Jagpal, Graeme Maclennon, Seonaidh C Cotton, Sofia A Papadopoulo, Nicholas Bunce, Pitt Lim, Konstantin Schwarz, Satnam Singh, David Hildick-Smith, John D Horowitz, Melanie Madhani, Nicholas Boon, Juan-Carlos Kaski…
    Citation: Journal of Translational Medicine 2013 11:116
  5. Diabetes mellitus is affecting more than 300 million people worldwide. Current treatment strategies cannot prevent secondary complications. Stem cells due to their regenerative power have long been the attract...

    Authors: Muhammad Tariq, Muhammad Sharif Masoud, Azra Mehmood, Shaheen N Khan and Sheikh Riazuddin
    Citation: Journal of Translational Medicine 2013 11:115
  6. Although the prognostic roles of β-catenin expression in non-small cell lung cancer (NSCLC) have been reported in several immunohistochemical (IHC) studies, the results were not consistent because some studies...

    Authors: Xi-Qing Li, Xing-Long Yang, Gong Zhang, Si-Pei Wu, Xu-Bing Deng, Sheng-Jun Xiao, Qiu-Zhen Liu, Kai-Tai Yao and Guang-Hui Xiao
    Citation: Journal of Translational Medicine 2013 11:114
  7. Catalase (CAT) breaks down H2O2 into H2O and O2 to protects cells from oxidative damage. However, its translational potential is limited because exogenous CAT cannot enter living cells automatically. This study i...

    Authors: Lei Zhang, Shuang Wei, Jun-Ming Tang, Ling-Yun Guo, Fei Zheng, Jian-Ye Yang, Xia Kong, Yong-Zhang Huang, Shi-You Chen and Jia-Ning Wang
    Citation: Journal of Translational Medicine 2013 11:113
  8. Special AT-rich sequence binding protein 1 (SATB1) is a nuclear factor that functions as the global chromatin organizer to regulate chromatin structure and gene expression gene expression. SATB1 has been shown...

    Authors: Lijun Mao, Chunhua Yang, Junqi Wang, Wang Li, Rumin Wen, Jiacun Chen and Junnian Zheng
    Citation: Journal of Translational Medicine 2013 11:111
  9. Studies of primary patient tumor xenografts grown in immunodeficient mice have shown that these tumors histologically and genetically closely resemble the original tumors. These patient xenograft models are be...

    Authors: Bonnie L Hylander, Natalie Punt, Haikuo Tang, Joanna Hillman, Mary Vaughan, Wiam Bshara, Rose Pitoniak and Elizabeth A Repasky
    Citation: Journal of Translational Medicine 2013 11:110
  10. Idiopathic calcium nephrolithiasis is a multifactorial disease with a complex pathogenesis due to genetic and environmental factors. The importance of social and health effects of nephrolithiasis is further hi...

    Authors: Elena Dogliotti, Giuseppe Vezzoli, Antonio Nouvenne, Tiziana Meschi, Annalisa Terranegra, Alessandra Mingione, Caterina Brasacchio, Benedetta Raspini, Daniele Cusi and Laura Soldati
    Citation: Journal of Translational Medicine 2013 11:109
  11. CTLA-4 (Cytotoxic T lymphocyte antigen-4) is traditionally known as a negative regulator of T cell activation. The blocking of CTLA-4 using human monoclonal antibodies, such as Ipilimumab, is currently used to...

    Authors: Stefania Laurent, Paola Queirolo, Silvia Boero, Sandra Salvi, Patrizia Piccioli, Simona Boccardo, Simona Minghelli, Anna Morabito, Vincenzo Fontana, Gabriella Pietra, Paolo Carrega, Nicoletta Ferrari, Francesca Tosetti, Lung-Ji Chang, Maria Cristina Mingari, Guido Ferlazzo…
    Citation: Journal of Translational Medicine 2013 11:108
  12. Neurodegenerative diseases such as Alzheimer’s are associated with the aggregation of endogenous peptides and proteins that contribute to neuronal dysfunction and loss. The glymphatic system, a brain-wide peri...

    Authors: Lijun Yang, Benjamin T Kress, Harris J Weber, Meenakshisundaram Thiyagarajan, Baozhi Wang, Rashid Deane, Helene Benveniste, Jeffrey J Iliff and Maiken Nedergaard
    Citation: Journal of Translational Medicine 2013 11:107
  13. Malignant pleural effusion (MPE) is associated with advanced stages of lung cancer and is mainly dependent on invasion of the pleura and expression of vascular endothelial growth factor (VEGF) by cancer cells....

    Authors: Stephanie Weibel, Elisabeth Hofmann, Thomas Christian Basse-Luesebrink, Ulrike Donat, Carolin Seubert, Marion Adelfinger, Prisca Gnamlin, Christina Kober, Alexa Frentzen, Ivaylo Gentschev, Peter Michael Jakob and Aladar A Szalay
    Citation: Journal of Translational Medicine 2013 11:106
  14. HCV is causing hundreds of cases yearly in Pakistan and has become a threat for Pakistani population. HCV E2 protein is a transmembrane protein involved in viral attachment and thus can serve as an important t...

    Authors: Sobia Idrees, Usman A Ashfaq and Saba Khaliq
    Citation: Journal of Translational Medicine 2013 11:105
  15. Tissue microarray (TMA) technology revolutionized the investigation of potential biomarkers from paraffin-embedded tissues. However, conventional TMA construction is laborious, time-consuming and imprecise. Ne...

    Authors: Inti Zlobec, Viktor H Koelzer, Heather Dawson, Aurel Perren and Alessandro Lugli
    Citation: Journal of Translational Medicine 2013 11:104
  16. Interactions between dendritic cells (DCs) and T cells play a critical role in the development of glomerulonephritis, which is a common cause of chronic kidney disease. DC-specific intercellular adhesion molec...

    Authors: Minchao Cai, Jing Wu, Chaoming Mao, Jianmin Ren, Pu Li, Xiao Li, Jiuchang Zhong, Chundi Xu and Tong Zhou
    Citation: Journal of Translational Medicine 2013 11:103
  17. Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the adult mammalian brain, but exerts physiologic effects other than that on neurotransmitter in non-neuronal peripheral tissues and or...

    Authors: Xiaoxue Zhang, Rong Zhang, Yuanjie Zheng, Jianfei Shen, Dakai Xiao, Jin Li, Xiaoshun Shi, Liyan Huang, Hailing Tang, Jun Liu, Jianxing He and Haibo Zhang
    Citation: Journal of Translational Medicine 2013 11:102
  18. Endothelium-dependent flow mediated dilation (FMD) and pulse-wave velocity (PWV), are used as measures of vascular health and predictors of cardiovascular risk in clinical studies, and both are age-dependent. ...

    Authors: Delvin R Knight Jr, Andrew H Smith, Richard L Schroeder, Chunli Huang, David A Beebe, Sharon A Sokolowski and Miao Wang
    Citation: Journal of Translational Medicine 2013 11:101
  19. The bone morphogenetic family proteins (BMP) are phytogenetically conserved proteins, which are essential for embryonic development. The key regulatory subunit, the bone morphogenetic protein 4 (BMP4), is over...

    Authors: Zhaoshi Bao, Chuanbao Zhang, Wei Yan, Yanwei Liu, Mingyang Li, Wei Zhang and Tao Jiang
    Citation: Journal of Translational Medicine 2013 11:100
  20. Serum thiols have shown associations with surrogate markers of cardiovascular disease. However, little information is available on their combined association with validated cardiovascular risk scores for prima...

    Authors: Arduino A Mangoni, Angelo Zinellu, Ciriaco Carru, John R Attia and Marc McEvoy
    Citation: Journal of Translational Medicine 2013 11:99
  21. Hepatopulmonary syndrome (HPS) is characterized by advanced liver disease, hypoxemia and intrapulmonary vascular dilatation (IPVD). The pathogenesis of HPS is not completely understood. Recent findings have es...

    Authors: Bin Yi, Jing Zeng, Guansong Wang, Guisheng Qian and Kaizhi Lu
    Citation: Journal of Translational Medicine 2013 11:98
  22. Vaccine treatment using multiple peptides derived from multiple proteins is considered to be a promising option for cancer immune therapy, but scientific evidence supporting the therapeutic efficacy of multipl...

    Authors: Hiroyuki Suzuki, Mitsuro Fukuhara, Takumi Yamaura, Satoshi Mutoh, Naoyuki Okabe, Hiroshi Yaginuma, Takeo Hasegawa, Atsushi Yonechi, Jun Osugi, Mika Hoshino, Takashi Kimura, Mitsunori Higuchi, Yutaka Shio, Kazuya Ise, Kazuyoshi Takeda and Mitsukazu Gotoh
    Citation: Journal of Translational Medicine 2013 11:97
  23. Mesenchymal stem cells (MSCs) are multi-potent non-hematopoietic progenitor cells possessing an immune-regulatory function, with suppression of proliferation of activated lymphocytes. In this study, adult livi...

    Authors: Hyunah Lee, Jae Berm Park, Sanghoon Lee, Soyoung Baek, HyunSoo Kim and Sung Joo Kim
    Citation: Journal of Translational Medicine 2013 11:96
  24. The traditional smallpox vaccine, administered by scarification, was discontinued in the general population from 1980, because of the absence of new smallpox cases. However, the development of an effective pro...

    Authors: Sole Maria Pacchioni, Massimiliano Bissa, Carlo Zanotto, Carlo De Giuli Morghen, Elena Illiano and Antonia Radaelli
    Citation: Journal of Translational Medicine 2013 11:95
  25. Our vision of cancer has changed during the past decades. Indeed tumors are now perceived as complex entities where tumoral and stromal components interact closely. Among the different elements of tumor stroma...

    Authors: Jennifer Pasquier, Bella S Guerrouahen, Hamda Al Thawadi, Pegah Ghiabi, Mahtab Maleki, Nadine Abu-Kaoud, Arthur Jacob, Massoud Mirshahi, Ludovic Galas, Shahin Rafii, Frank Le Foll and Arash Rafii
    Citation: Journal of Translational Medicine 2013 11:94
  26. Chronic fatigue syndrome (CFS) is a debilitating disorder characterized by persistent fatigue that is not alleviated by rest. The lack of a clearly identified underlying mechanism has hindered the development ...

    Authors: Elizabeth Ann Stringer, Katharine Susanne Baker, Ian R Carroll, Jose G Montoya, Lily Chu, Holden T Maecker and Jarred W Younger
    Citation: Journal of Translational Medicine 2013 11:93
  27. Basigin, which has four isoforms, has been demonstrated to be involved in progression of various human cancers. The aim of this study was to examine the prognostic value of basigin-2 protein expression in epit...

    Authors: Shu-Hua Zhao, Yu Wang, Li Wen, Zhen-Bo Zhai, Zhen-Hua Ai, Nian-Ling Yao, Li Wang, Wen-Chao Liu, Bi-Liang Chen, Yu Li and Hong Yang
    Citation: Journal of Translational Medicine 2013 11:92
  28. Celiac disease (CD) is mainly characterised by villous atrophy and mucosal architectural rearrangement. The fibroblasts (FBs) are the most abundant mesenchymal cell type in the intestinal mucosa and are respon...

    Authors: Leda Roncoroni, Luca Elli, Maria Teresa Bardella, Gianluca Perrucci, Michele Ciulla, Vincenza Lombardo, Carolina Tomba, Dario Conte and Luisa Doneda
    Citation: Journal of Translational Medicine 2013 11:91
  29. This study was designed to determine whether advanced non-small-cell lung cancer (NSCLC) patients with high copy number of epidermal growth factor receptor (EGFR) can benefit from treatment with EGFR-tyrosine ...

    Authors: Fang Wang, Sha Fu, Qiong Shao, Yan-Bin Zhou, Xiao Zhang, Xu Zhang, Cong Xue, Jian-Guang Lin, Li-Xia Huang, Li Zhang, Wei-Min Zhang and Jian-Yong Shao
    Citation: Journal of Translational Medicine 2013 11:90
  30. The FDA recently approved an anti-CTLA-4 antibody (Iplimumab) for the treatment of metastatic melanoma. This decision was based on Phase III results, which demonstrate that blocking this immune checkpoint prov...

    Authors: Satoshi Wada, Christopher M Jackson, Kiyoshi Yoshimura, Hung-Rong Yen, Derese Getnet, Timothy J Harris, Monica V Goldberg, Tullia C Bruno, Joseph F Grosso, Nicholas Durham, George J Netto, Drew M Pardoll and Charles G Drake
    Citation: Journal of Translational Medicine 2013 11:89
  31. Human papilloma virus type 16 (HPV16)-induced gynecological cancers, in particular cervical cancers, are found in many women worldwide. The HPV16 encoded oncoproteins E6 and E7 are tumor-specific targets for t...

    Authors: Mariette I E van Poelgeest, Marij J P Welters, Edith M G van Esch, Linda F M Stynenbosch, Gijs Kerpershoek, Els L van Persijn van Meerten, Muriel van den Hende, Margriet J G Löwik, Dorien M A Berends-van der Meer, Lorraine M Fathers, A Rob P M Valentijn, Jaap Oostendorp, Gert Jan Fleuren, Cornelis J M Melief, Gemma G Kenter and Sjoerd H van der Burg
    Citation: Journal of Translational Medicine 2013 11:88
  32. Sevoflurane is an anesthetic agent which also participates in protective mechanisms in sepsis, likely due to anti-inflammatory properties. A key tissue in sepsis is the endothelium, which expresses TLR2 and TL...

    Authors: Raquel Rodríguez-González, Aurora Baluja, Sonia Veiras Del Río, Alfonso Rodríguez, Jaime Rodríguez, Manuel Taboada, David Brea and Julián Álvarez
    Citation: Journal of Translational Medicine 2013 11:87
  33. The use of adenoviral vector for gene therapy is still an important strategy for advanced cancers, however, the lack of the requisite coxsackie-adenovirus receptor in cancer cells and host immune response to a...

    Authors: Hua-shan Shi, Li-ping Yang, Wei Wei, Xiao-qing Su, Xiao-peng Li, Meng Li, Shun-tao Luo, Hai-long Zhang, Lian Lu, Yong-qiu Mao, Bing Kan and Li Yang
    Citation: Journal of Translational Medicine 2013 11:86
  34. Sequencing of the human genome and the subsequent analyses have produced immense volumes of data. The technological advances have opened new windows into genomics beyond the DNA sequence. In parallel, clinical...

    Authors: Imad Abugessaisa, David Gomez-Cabrero, Omri Snir, Staffan Lindblad, Lars Klareskog, Vivianne Malmström and Jesper Tegnér
    Citation: Journal of Translational Medicine 2013 11:85
  35. Lixisenatide is a glucagon-like peptide-1 analog which stimulates insulin secretion and inhibits glucagon secretion and gastric emptying. We investigated cardioprotective effects of lixisenatide in rodent mode...

    Authors: Paulus Wohlfart, Wolfgang Linz, Thomas Hübschle, Dominik Linz, Jochen Huber, Sibylle Hess, Daniel Crowther, Ulrich Werner and Hartmut Ruetten
    Citation: Journal of Translational Medicine 2013 11:84
  36. The number of immune cells, especially dendritic cells and cytotoxic tumor infiltrating lymphocytes (TIL), particularly Th1 cells, CD8 T cells, and NK cells is associated with increased survival of cancer pati...

    Authors: Jingting Jiang, Changping Wu and Binfeng Lu
    Citation: Journal of Translational Medicine 2013 11:83
  37. Authors: Erika Hamilton, Kimberly Blackwell, Amy C Hobeika, Timothy M Clay, Gloria Broadwater, Xiu-Rong Ren, Wei Chen, Henry Castro, Frederic Lehmann, Neil Spector, Junping Wei, Takuya Osada, H Kim Lyerly and Michael A Morse
    Citation: Journal of Translational Medicine 2013 11:82

    The original article was published in Journal of Translational Medicine 2012 10:28

  38. Angiogenesis is a critical part of the endogenous repair process in brain injury and disease, and requires at least two sequential steps. First, angiogenic sprouting of endothelial cells occurs, which entails ...

    Authors: Mo Dao, Ciara C Tate, Michael McGrogan and Casey C Case
    Citation: Journal of Translational Medicine 2013 11:81
  39. Ritonavir is a HIV protease inhibitor. In addition to its antiviral effect, Ritonavir directly inhibits the insulin-regulated glucose transporter GLUT4 and blocks glucose entry into fat and muscle cells. Howev...

    Authors: Prachi Gupta, Abhinav Kanwal, Uday Kumar Putcha, Yogesh Bulani, Bhavesh Sojitra, Tarak Nath Khatua, Madhusudana Kuncha and Sanjay Kumar Banerjee
    Citation: Journal of Translational Medicine 2013 11:80
  40. Despite availability of efficient treatment regimens for early stage colorectal cancer, treatment regimens for late stage colorectal cancer are generally not effective and thus need improvement. Oncolytic viro...

    Authors: Klaas Ehrig, Mehmet O Kilinc, Nanhai G Chen, Jochen Stritzker, Lisa Buckel, Qian Zhang and Aladar A Szalay
    Citation: Journal of Translational Medicine 2013 11:79
  41. Mesenchymal stem cell (MSC) transplantation has emerged as a promising therapy for liver fibrosis. Issues concerning poor MSC survival and engraftment in the fibrotic liver still persist and warrant developmen...

    Authors: Ghazanfar Ali Nasir, Sadia Mohsin, Mohsin Khan, Sulaiman Shams, Gibran Ali, Shaheen N Khan and Sheikh Riazuddin
    Citation: Journal of Translational Medicine 2013 11:78
  42. Multiple myeloma (MM) is a low proliferative tumor of postgerminal center plasma cell (PC). Centrosome amplification (CA) is supposed to be one of the mechanisms leading to chromosomal instability. Also, CA is...

    Authors: Elena Dementyeva, Fedor Kryukov, Lenka Kubiczkova, Pavel Nemec, Sabina Sevcikova, Ivana Ihnatova, Jiri Jarkovsky, Jiri Minarik, Zdena Stefanikova, Petr Kuglik and Roman Hajek
    Citation: Journal of Translational Medicine 2013 11:77
  43. The phosphatidylinositol 3-kinase (PI3K) pathway plays an important role in multiple myeloma (MM), a blood cancer associated with uncontrolled proliferation of bone marrow plasma cells. This study aimed to dev...

    Authors: Congfen Li, Chikara Takahashi, Liangxuan Zhang, Mahrukh Huseni, Basha Stankovich, Haider Mashhedi, Joanna Lee, Dorothy French, Jeff Eastham Anderson, Doris Kim, Kathy Howell, Matthew J Brauer, Marcin Kowanetz, Yibing Yan, Eric Humke, Allen Ebens…
    Citation: Journal of Translational Medicine 2013 11:76
  44. Treatment with ipilimumab, a fully human anti-CTLA-4 antibody approved for the treatment of advanced melanoma, is associated with some immune-related adverse events (irAEs) such as colitis (gastrointestinal ir...

    Authors: Vafa Shahabi, David Berman, Scott D Chasalow, Lisu Wang, Zenta Tsuchihashi, Beihong Hu, Lisa Panting, Maria Jure-Kunkel and Rui-Ru Ji
    Citation: Journal of Translational Medicine 2013 11:75
  45. Cell penetrating peptides have gained much recognition as a versatile transport vehicle for the intracellular delivery of wide range of cargoes (i.e. oligonucelotides, small molecules, proteins, etc.), that other...

    Authors: Ankur Gautam, Kumardeep Chaudhary, Rahul Kumar, Arun Sharma, Pallavi Kapoor, Atul Tyagi and Gajendra P S Raghava
    Citation: Journal of Translational Medicine 2013 11:74
  46. Personalized chemotherapy based on molecular biomarkers can maximize anticancer efficiency. We aim to investigate predictive biomarkers capable of predicting response to irinotecan-based treatment in gastric c...

    Authors: Jie Shen, Jia Wei, Hao Wang, Guofeng Yue, Lixia Yu, Yang Yang, Li Xie, Zhengyun Zou, Xiaoping Qian, Yitao Ding, Wenxian Guan and Baorui Liu
    Citation: Journal of Translational Medicine 2013 11:73
  47. Interleukin (IL)-6 (mainly of tumor origin) activates glutathione (GSH) release from hepatocytes and its interorgan transport to B16-F10 melanoma metastatic foci. We studied if this capacity to overproduce IL-...

    Authors: Soraya L Valles, María Benlloch, María L Rodriguez, Salvador Mena, José A Pellicer, Miguel Asensi, Elena Obrador and José M Estrela
    Citation: Journal of Translational Medicine 2013 11:72
  48. CD8+ T cells are key members of adaptive immunity against tumorigenesis. As subset of CD8+ T cells, effector T cells (Te) and memory T cells (Tm) have different biological activities. The former can kill tumor...

    Authors: Guocheng Zhong, Xiaoming Cheng, Haixia Long, Luhang He, Wei Qi, Tong Xiang, Zhongquan Zhao and Bo Zhu
    Citation: Journal of Translational Medicine 2013 11:71

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