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Page 109 of 143

  1. MicroRNAs (miRNAs) can act as either oncogenes or tumor suppressor genes under different conditions and thus can play a significant role in cancer development. We investigated miR-655 expression in a cohort of...

    Authors: Yuanyuan Wang, Wenqiao Zang, Yuwen Du, Yunyun Ma, Min Li, Ping Li, Xudong Chen, Tao Wang, Ziming Dong and Guoqiang Zhao
    Citation: Journal of Translational Medicine 2013 11:301

    The Retraction Note to this article has been published in Journal of Translational Medicine 2020 18:89

  2. Heat shock proteins (HSPs) are capable of promoting antigen presentation of chaperoned peptides through interactions with receptors on antigen presenting cells. This property of HSPs suggests a potential funct...

    Authors: Juhong Jiang, Dan Xie, Wenmin Zhang, Gang Xiao and Jianming Wen
    Citation: Journal of Translational Medicine 2013 11:300
  3. Conformal intensity-modulated radiation therapy (IMRT) involves irradiation of large volume of normal tissue with low and medium doses, biological relevance of which is not clear yet. Serum proteome features w...

    Authors: Piotr Widłak, Monika Pietrowska, Joanna Polańska, Tomasz Rutkowski, Karol Jelonek, Magdalena Kalinowska-Herok, Agnieszka Gdowicz-Kłosok, Andrzej Wygoda, Rafał Tarnawski and Krzysztof Składowski
    Citation: Journal of Translational Medicine 2013 11:299
  4. Bone marrow stromal cells (BMSCs) are multipotent cells that support angiogenesis, wound healing, and immunomodulation. In the hematopoietic niche, they nurture hematopoietic cells, leukemia, tumors and metast...

    Authors: Sara Civini, Ping Jin, Jiaqiang Ren, Marianna Sabatino, Luciano Castiello, Jianjian Jin, Huan Wang, Yuanlong Zhao, Francesco Marincola and David Stroncek
    Citation: Journal of Translational Medicine 2013 11:298
  5. INI1 (Integrase interactor 1), also known as SMARCB1, is the most studied subunit of chromatin remodelling complexes. Its role in colorectal tumorigenesis is not known.

    Authors: Massimo Pancione, Andrea Remo, Caterina Zanella, Lina Sabatino, Arturo Di Blasi, Carmelo Laudanna, Laura Astati, Michele Rocco, Delfina Bifano, Paolo Piacentini, Laura Pavan, Alberto Purgato, Filippo Greco, Alberto Talamini, Andrea Bonetti, Michele Ceccarelli…
    Citation: Journal of Translational Medicine 2013 11:297
  6. Rho GTPases play important roles in cytoskeleton organization, cell cycle progression and are key regulators of tumor progression. Strategies to modulate increased Rho GTPase activities during cancer progressi...

    Authors: Karin Zins, Sandun Gunawardhana, Trevor Lucas, Dietmar Abraham and Seyedhossein Aharinejad
    Citation: Journal of Translational Medicine 2013 11:295
  7. For thousands of years, it remains unclear why Chinese prefer complex herbal remedy and seldom try to purify it. One of the reasons is that they believe Chinese herbs compared to Western drugs are relatively l...

    Authors: Ling-Jun Ho, Wen-Liang Chang, Ann Chen, Ping Chao and Jenn-Haung Lai
    Citation: Journal of Translational Medicine 2013 11:294
  8. Obesity is a well established risk factor of colorectal cancer (CRC), but how body size influences risk of colorectal cancer defined by key molecular alterations remains unclear. In this study, we investigated...

    Authors: Jenny Brändstedt, Sakarias Wangefjord, Signe Borgquist, Björn Nodin, Jakob Eberhard, Jonas Manjer and Karin Jirström
    Citation: Journal of Translational Medicine 2013 11:293
  9. Everolimus (EVE) is a drug widely used in several renal transplant protocols. Although characterized by a relatively low nephrotoxicity, it may induce several adverse effects including severe fibro-interstitia...

    Authors: Valentina Masola, Gianluigi Zaza, Simona Granata, Giovanni Gambaro, Maurizio Onisto and Antonio Lupo
    Citation: Journal of Translational Medicine 2013 11:292
  10. We previously developed an immunotherapy treatment utilizing a cancer vaccine reagent KIF20A-66 in order to treat pancreatic cancer. KIF20A-66 is HLA-A24-restricted epitope peptide derived from KIF20A, a membe...

    Authors: Shingo Asahara, Kazuyoshi Takeda, Kenji Yamao, Hiroyuki Maguchi and Hiroki Yamaue
    Citation: Journal of Translational Medicine 2013 11:291
  11. Malignancies induce changes in the levels of serum amino acids (AA), which may offer diagnostic potential. Furthermore, changes in AA levels are associated with immune cell function. In this study, serum AA le...

    Authors: Isabel Poschke, Yumeng Mao, Rolf Kiessling and Jana de Boniface
    Citation: Journal of Translational Medicine 2013 11:290
  12. The capacity of patient’s Natural Killer cells (NKs) to be activated for cytolysis is an important prerequisite for the success of antibody-derived agents such as single-chain triplebodies (triplebodies) in ca...

    Authors: Todd A Braciak, Sarah Wildenhain, Claudia C Roskopf, Ingo A Schubert, Georg H Fey, Uwe Jacob, Karl-Peter Hopfner and Fuat S Oduncu
    Citation: Journal of Translational Medicine 2013 11:289
  13. Cadherin 12 (CDH12), which encodes a type II classical cadherin from the cadherin superfamily, may mediate calcium-dependent cell adhesion. It has been demonstrated that CDH12 could play an important role in t...

    Authors: Jingkun Zhao, Pu Li, Hao Feng, Puxiongzhi Wang, Yaping Zong, Junjun Ma, Zhuo Zhang, Xuehua Chen, Minhua Zheng, Zhenggang Zhu and Aiguo Lu
    Citation: Journal of Translational Medicine 2013 11:288
  14. Selenoprotein S (SelS) is an important endoplasmic reticulum and plasma membrane-located selenoprotein implicated in inflammatory responses and insulin resistance. However, the effects of SelS on endothelial c...

    Authors: Yin Zhao, Hua Li, Li-li Men, Rong-chong Huang, Hai-cheng Zhou, Qian Xing, Jun-jie Yao, Chun-hong Shi and Jian-ling Du
    Citation: Journal of Translational Medicine 2013 11:287
  15. ARA290 is a non-erythropoietic EPO derivative which only binds to the cytoprotective receptor complex (EPOR2-βcR2) consisting of two EPO-receptors (EPOR) and two β common receptors (βcR). ARA290 is renoprotective...

    Authors: Willem G van Rijt, Gertrude J Nieuwenhuijs-Moeke, Harry van Goor, Petra J Ottens, Rutger J Ploeg and Henri GD Leuvenink
    Citation: Journal of Translational Medicine 2013 11:286
  16. The goal of this study was to test the hypothesis that autoantibodies against M2-muscarinic acetylcholine receptor (M2-AAB) are associated with severe preeclampsia and increased risk of adverse perinatal outcomes...

    Authors: Yanfang Li, Guiling Ma, Zhiyong Zhang, Yin Yue, Yuting Yuan, Yidan Wang, Guobin Miao and Lin Zhang
    Citation: Journal of Translational Medicine 2013 11:285
  17. Inherited genetic defects play an important role in congenital hearing loss, contributing to about 60% of deafness occurring in infants. Hereditary nonsyndromic hearing loss is highly heterogeneous, and most p...

    Authors: Xue Gao, Qing-yan Zhu, Yue-Shuai Song, Guo-Jian Wang, Yong-Yi Yuan, Feng Xin, Sha-Sha Huang, Dong-Yang Kang, Ming-Yu Han, Li-ping Guan, Jian-guo Zhang and Pu Dai
    Citation: Journal of Translational Medicine 2013 11:284
  18. Little is known about the involvement of matrix metalloproteinases (MMPs) in cardiac vascular remodelling induced by exercise. Our aim was to evaluate and localize MMP-2 and MMP-9’s activities in relation to c...

    Authors: Marianna Bellafiore, Giuseppe Battaglia, Antonino Bianco, Felicia Farina, Antonio Palma and Antonio Paoli
    Citation: Journal of Translational Medicine 2013 11:283
  19. In recent years an increasing number of publications have emphasized the growing importance of hydrogen ion dynamics in modern cancer research, from etiopathogenesis and treatment. A proton [H+]-related mechanism...

    Authors: Salvador Harguindey, Jose Luis Arranz, Julian David Polo Orozco, Cyril Rauch, Stefano Fais, Rosa Angela Cardone and Stephan J Reshkin
    Citation: Journal of Translational Medicine 2013 11:282
  20. The ability to forecast whether a wound will heal after closure without further debridement(s), would provide substantial benefits to patients with severe extremity trauma.

    Authors: Brett A Chromy, Angela Eldridge, Jonathan A Forsberg, Trevor S Brown, Benjamin C Kirkup, Crystal Jaing, Nicholas A Be, Eric Elster and Paul A Luciw
    Citation: Journal of Translational Medicine 2013 11:281
  21. Triple-negative breast cancer (TNBC) is an aggressive clinical subtype of breast cancer that is characterized by the lack of estrogen receptor (ER) and progesterone receptor (PR) expression as well as human ep...

    Authors: Birdal Bilir, Omer Kucuk and Carlos S Moreno
    Citation: Journal of Translational Medicine 2013 11:280
  22. Steadily high melanoma mortality rates urge for the availability of novel biomarkers with a more personalized ability to predict melanoma clinical outcomes. Germline risk variants are promising candidates for ...

    Authors: Justin Rendleman, Shulian Shang, Christine Dominianni, Jerry F Shields, Patrick Scanlon, Christina Adaniel, Alexis Desrichard, Michelle Ma, Richard Shapiro, Russell Berman, Anna Pavlick, David Polsky, Yongzhao Shao, Iman Osman and Tomas Kirchhoff
    Citation: Journal of Translational Medicine 2013 11:279
  23. Numerous studies have shown that early screening for the presence of pre-cancerous colon polyps and their subsequent removal decreases the risk of developing colon cancer. Colonoscopy is currently the most eff...

    Authors: Markus Franz, Matthias Scholz, Ilka Henze, Stefan Röckl and Luis I Gomez
    Citation: Journal of Translational Medicine 2013 11:278
  24. Paxillin (PXN) has been found to be aberrantly regulated in various malignancies and involved in tumor growth and invasion. The clinicopathological and prognostic significance of PXN in gastric cancer is still...

    Authors: Dong-liang Chen, Zhi-qiang Wang, Chao Ren, Zhao-lei Zeng, De-shen Wang, Hui-yan Luo, Feng Wang, Miao-zhen Qiu, Long Bai, Dong-sheng Zhang, Feng-hua Wang, Yu-hong Li and Rui-hua Xu
    Citation: Journal of Translational Medicine 2013 11:277
  25. Increasing evidence has suggested that dysregulation of certain microRNAs (miRNAs) may contribute to human disease including carcinogenesis and tumor metastasis in human. miR-124-3p is down-regulated in variou...

    Authors: Xianglai Xu, Shiqi Li, Yiwei Lin, Hong Chen, Zhenghui Hu, Yeqing Mao, Xin Xu, Jian Wu, Yi Zhu, Xiangyi Zheng, Jindan Luo and Liping Xie
    Citation: Journal of Translational Medicine 2013 11:276
  26. Colorectal cancer (CRC) is the most common digestive system malignancy. The molecular events involved in the development and progression of CRC remain unclear. Recently, more and more evidences have showed tha...

    Authors: Limin Long, Guoqing Huang, Hongyi Zhu, Yonghong Guo, Youshuo Liu and Jirong Huo
    Citation: Journal of Translational Medicine 2013 11:275
  27. It takes several years on average to translate basic research findings into clinical research and eventually deliver patient benefits. An expert-based excellence assessment can help improve this process by: id...

    Authors: Abinaya Rajan, Carlos Caldas, Henri van Luenen, Mahasti Saghatchian and Wim H van Harten
    Citation: Journal of Translational Medicine 2013 11:274
  28. Residual tumor progression after insufficient radiofrequency ablation (RFA) has been recently reported. However, whether epithelial-mesenchymal transition (EMT), which is a key process that drives cancer metas...

    Authors: Shuying Dong, Jian Kong, Fandong Kong, Jinge Kong, Jun Gao, Shan Ke, Shaohong Wang, Xuemei Ding, Wenbing Sun and Lemin Zheng
    Citation: Journal of Translational Medicine 2013 11:273
  29. The La-related protein 1 (LARP1) has been found to be a RNA binding protein and was related to spermatogenesis, embryogenesis and cell-cycle progression. The aim of this study was to investigate the prognostic...

    Authors: Chan Xie, Li Huang, Shibin Xie, Dongying Xie, Genlin Zhang, Peipei Wang, Liang Peng and Zhiliang Gao
    Citation: Journal of Translational Medicine 2013 11:272
  30. Bone is one of the major target tissues for Insulin-like Growth Factor I (IGF-I). Low doses of IGF-I were able to improve liver-associated osteopenia. In the present work, a model of partial IGF-I deficiency w...

    Authors: Lucia Guerra-Menéndez, Maria C Sádaba, Juan E Puche, Jose L Lavandera, Luis F de Castro, Arancha R de Gortázar and Inma Castilla-Cortázar
    Citation: Journal of Translational Medicine 2013 11:271
  31. This study tested the hypothesis that exendin-4 and sitagliptin can effectively protect kidney from acute ischemia-reperfusion (IR) injury.

    Authors: Yen-Ta Chen, Tzu-Hsien Tsai, Chih-Chau Yang, Cheuk-Kwan Sun, Li-Teh Chang, Hung-Hwa Chen, Chia-Lo Chang, Pei-Hsun Sung, Yen-Yi Zhen, Steve Leu, Hsueh-Wen Chang, Yung-Lung Chen and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2013 11:270
  32. Transglutaminase-4 (TGase-4), also known as the Prostate Transglutaminase, is an enzyme found to be expressed predominately in the prostate gland. The protein has been recently reported to influence the migrat...

    Authors: Wen G Jiang, Lin Ye, Andrew J Sanders, Fiona Ruge, Howard G Kynaston, Richard J Ablin and Malcolm D Mason
    Citation: Journal of Translational Medicine 2013 11:269
  33. Major goals in translational oncology are to reduce systemic toxicity of current anticancer strategies and improve effectiveness. An extremely efficient cancer cell mechanism to avoid and/or reduce the effects...

    Authors: Stefano Ferrari, Francesca Perut, Franca Fagioli, Adalberto Brach Del Prever, Cristina Meazza, Antonina Parafioriti, Piero Picci, Marco Gambarotti, Sofia Avnet, Nicola Baldini and Stefano Fais
    Citation: Journal of Translational Medicine 2013 11:268
  34. B cell malignancies are characterized by clonal expansion of B cells expressing tumor-specific idiotypes on their surface. These idiotypes are ideal target antigens for an individualized immunotherapy. However...

    Authors: Tim Roehnisch, Cornelia Then, Wolfgang Nagel, Christina Blumenthal, Todd Braciak, Mariel Donzeau, Thomas Böhm, Carole Bourquin and Fuat Oduncu
    Citation: Journal of Translational Medicine 2013 11:267
  35. Alcohol consumption is a major cause of liver disease in humans. The use and monitoring of biomarkers associated with early, pre-clinical stages of alcohol-induced liver disease (pre-ALD) could facilitate diag...

    Authors: Heng-Hong Li, Kathryn Doiron, Andrew D Patterson, Frank J Gonzalez and Albert J Fornace Jr
    Citation: Journal of Translational Medicine 2013 11:266
  36. Homoharringtonine (HHT) is a kind of cephalotaxus alkaloid used in traditional Chinese medicine. Although HHT has been successfully used as a therapeutic agent for leukemia, the drug resistance and toxicity ar...

    Authors: MinRan Zhou, JiPing Zeng, XiaoMing Wang, Qing Guo, Tao Huang, HaiYu Shen, Yue Fu, LiXiang Wang, JiHui Jia and ChunYan Chen
    Citation: Journal of Translational Medicine 2013 11:265
  37. Human colon adenocarcinoma cells are resistant to chemotherapeutic agents, such as anthracyclines, that induce death by increasing the reactive oxygen species. A number of studies have been focused on chemo-pr...

    Authors: Salvatore De Maria, Ilaria Scognamiglio, Angela Lombardi, Nicola Amodio, Michele Caraglia, Maria Cartenì, Gianpietro Ravagnan and Paola Stiuso
    Citation: Journal of Translational Medicine 2013 11:264
  38. Insulin resistance (IR) is frequently associated with endothelial dysfunction and has been proposed to play a major role in cardiovascular disease (CVD). On the other hand, obesity has long been related to IR ...

    Authors: Mariam El Assar, Juan Carlos Ruiz de Adana, Javier Angulo, María Luz Pindado Martínez, Alberto Hernández Matías and Leocadio Rodríguez-Mañas
    Citation: Journal of Translational Medicine 2013 11:263
  39. Digestive malignancies, especially pancreatic cancer (PC), gastric cancer (GC), and colorectal cancer (CRC), still occur at persistently high rates, and disease progression in these cancers has been associated...

    Authors: Yun-Peng Peng, Yi Zhu, Jing-Jing Zhang, Ze-Kuan Xu, Zhu-Yin Qian, Cun-Cai Dai, Kui-Rong Jiang, Jun-Li Wu, Wen-Tao Gao, Qiang Li, Qing Du and Yi Miao
    Citation: Journal of Translational Medicine 2013 11:262
  40. Both apoptosis and autoantibodies are important factors associated with disease activity in the pathogenesis of systemic lupus erythematosus (SLE). This study tested the hypothesis that increased leukocyte apo...

    Authors: Yu-Jih Su, Tien-Tsai Cheng, Chung-Jen Chen, Wen-Chan Chiu, Chung-Yuan Hsu, Wen-Neng Chang, Nai-Wen Tsai, Chia-Te Kung, Hung-Chen Wang, Wei-Che Lin, Chih-Cheng Huang, Ya-Ting Chang, Chih-Min Su, Yi-Fang Chiang, Ben-Chung Cheng, Yu-Jun Lin…
    Citation: Journal of Translational Medicine 2013 11:261
  41. Atherosclerosis is the main cause of morbidity and mortality in Western countries and carotid plaque rupture is associated to acute events and responsible of 15-20% of all ischemic strokes. Several proteomics ...

    Authors: Silvia Rocchiccioli, Gualtiero Pelosi, Silvia Rosini, Michele Marconi, Federica Viglione, Lorenzo Citti, Mauro Ferrari, Maria Giovanna Trivella and Antonella Cecchettini
    Citation: Journal of Translational Medicine 2013 11:260
  42. Dinaciclib, a small-molecule, cyclin-dependent kinase inhibitor, inhibits cell cycle progression and proliferation in various tumor cell lines in vitro. We conducted an open-label, dose-escalation study to det...

    Authors: John J Nemunaitis, Karen A Small, Paul Kirschmeier, Da Zhang, Yali Zhu, Ying-Ming Jou, Paul Statkevich, Siu-Long Yao and Rajat Bannerji
    Citation: Journal of Translational Medicine 2013 11:259
  43. Matrix metalloproteinases can promote invasion and metastasis, which are very frequent in renal cell carcinoma even at the time of diagnosis. Knowing the reversion-inducing cysteine-rich protein with Kazal mot...

    Authors: Anja Rabien, Carsten Stephan, Ergin Kilic, Wilko Weichert, Glen Kristiansen, Kurt Miller, Klaus Jung and Andreas Erbersdobler
    Citation: Journal of Translational Medicine 2013 11:258
  44. Gene therapy using a recombinant adenovirus (Ad) encoding secretory human endostatin (Ad-Endo) has been demonstrated to be a promising antiangiogenesis and antitumor strategy of in animal models and clinical t...

    Authors: Li-xia Li, Yan-ling Zhang, Ling Zhou, Miao-la Ke, Jie-min Chen, Xiang Fu, Chun-ling Ye, Jiang-xue Wu, Ran-yi Liu and Wenlin Huang
    Citation: Journal of Translational Medicine 2013 11:257
  45. Translational medicine is attracting much attention worldwide and many translational research organizations (TROs) have been established. In China, translational medicine has developed rapidly, but faces many ...

    Authors: Laixin Zhou, Ying Li, Hayden B Bosworth, John Ehiri and Changkun Luo
    Citation: Journal of Translational Medicine 2013 11:256
  46. Up to 40% of patients initially diagnosed with clinically-confined renal cell carcinoma (RCC) and who undergo curative surgery will nevertheless relapse with metastatic disease (mRCC) associated with poor long...

    Authors: Lee Campbell, Ghaith Al-Jayyoussi, Robert Gutteridge, Nigel Gumbleton, Rosie Griffiths, Simon Gumbleton, Mathew W Smith, David FR Griffiths and Mark Gumbleton
    Citation: Journal of Translational Medicine 2013 11:255
  47. To overcome the absorption of traditional fat grafting, techniques for adipose-derived regenerative cell (ADRC)-enriched fat grafting are currently being adapted for practical application. The Celution®800/CRS...

    Authors: Natsuko Kakudo, Yoshihito Tanaka, Naoki Morimoto, Takeshi Ogawa, Satoshi Kushida, Tomoya Hara and Kenji Kusumoto
    Citation: Journal of Translational Medicine 2013 11:254
  48. Although the potential of biomarkers to aid in early detection of colorectal cancer (CRC) is recognized and numerous biomarker candidates have been reported in the literature, to date only few molecular marker...

    Authors: Stine Buch Thorsen, Martin Lundberg, Andrea Villablanca, Sarah Louise T Christensen, Kirstine Christensen Belling, Birgitte Sander Nielsen, Mick Knowles, Nick Gee, Hans Jørgen Nielsen, Nils Brünner, Ib Jarle Christensen, Simon Fredriksson, Jan Stenvang and Erika Assarsson
    Citation: Journal of Translational Medicine 2013 11:253
  49. Notch signaling is known to be activated following myocardial ischemia, but its role in cardioprotection provided by ischemic preconditioning (IPC) and ischemic postconditioning (IPost) remains unclear.

    Authors: Xue-liang Zhou, Li Wan, Qi-rong Xu, Yong Zhao and Ji-chun Liu
    Citation: Journal of Translational Medicine 2013 11:251

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