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  1. Calcium nephrolithiasis may be considered as a complex disease having multiple pathogenetic mechanisms and characterized by various clinical manifestations. Both genetic and environmental factors may increase ...

    Authors: Giuseppe Vezzoli, Annalisa Terranegra, Francesco Rainone, Teresa Arcidiacono, Mario Cozzolino, Andrea Aloia, Elena Dogliotti, Daniele Cusi and Laura Soldati
    Citation: Journal of Translational Medicine 2011 9:201
  2. The PI3K/Akt pathway is involved in cellular survival pathways by inhibiting apoptotic processes and stimulating cell growth and proliferation. Its negative prognostic value has been proven in many types of ca...

    Authors: Andrej Valkov, Thomas K Kilvaer, Sveinung W Sorbye, Tom Donnem, Eivind Smeland, Roy M Bremnes and Lill-Tove Busund
    Citation: Journal of Translational Medicine 2011 9:200
  3. Millions of people all over the world are constantly sharing an extremely wide range of fascinating, quirky, funny, irrelevant and important content all at once. Even scientists are no strangers to this trend....

    Authors: Laura Van Eperen and Francesco M Marincola
    Citation: Journal of Translational Medicine 2011 9:199
  4. Dendritic cells (DCs) are the most potent antigen-presenting cell population for activating tumor-specific T cells. Due to the wide range of methods for generating DCs, there is no common protocol or defined s...

    Authors: Cheryl L-L Chiang, Dawn A Maier, Lana E Kandalaft, Andrea L Brennan, Evripidis Lanitis, Qunrui Ye, Bruce L Levine, Brian J Czerniecki, Daniel J Powell Jr and George Coukos
    Citation: Journal of Translational Medicine 2011 9:198
  5. Aberrant expression of small noncoding RNAs called microRNAs (miRNAs) is a common feature of several human diseases. The objective of the study was to identify miRNA modulation in patients with complex regiona...

    Authors: Irina A Orlova, Guillermo M Alexander, Rehman A Qureshi, Ahmet Sacan, Alessandro Graziano, James E Barrett, Robert J Schwartzman and Seena K Ajit
    Citation: Journal of Translational Medicine 2011 9:195
  6. HCV causes acute and chronic hepatitis which can eventually lead to permanent liver damage hepatocellular carcinoma and death. HCV glycoproteins play an important role in HCV entry by binding with CD81 recepto...

    Authors: Usman A Ashfaq, Muhammad Qasim, Muhammad Z Yousaf, Muhammad Tariq Awan and Shah Jahan
    Citation: Journal of Translational Medicine 2011 9:194
  7. Expression of Dkk-3, a secreted putative tumor suppressor, is altered in age-related proliferative disorders of the human prostate. We now investigated the suitability of Dkk-3 as a diagnostic biomarker for pr...

    Authors: Christoph Zenzmaier, Martin Heitz, Helmut Klocker, Marion Buck, Robert A Gardiner and Peter Berger
    Citation: Journal of Translational Medicine 2011 9:193
  8. The lack of effective treatments for gliomas makes them a significant health problem and highlights the need for the development of novel and innovative treatment approaches. Immunotherapy is an appealing stra...

    Authors: Veerauo V Konkankit, Won Kim, Richard C Koya, Ascia Eskin, Mai-Anh Dam, Stanley Nelson, Antoni Ribas, Linda M Liau and Robert M Prins
    Citation: Journal of Translational Medicine 2011 9:192
  9. T-cell based immunotherapy for lung cancer (LC) could be a promising and novel therapeutic approach. Six-transmembrane epithelial antigen of the prostate (STEAP) and the polycomb group protein enhancer of zest...

    Authors: Satoshi Hayashi, Takumi Kumai, Yoshiya Matsuda, Naoko Aoki, Keisuke Sato, Shoji Kimura, Masahiro Kitada, Masatoshi Tateno, Esteban Celis and Hiroya Kobayashi
    Citation: Journal of Translational Medicine 2011 9:191
  10. Human papilloma virus (HPV)-16 is the most prevalent high-risk mucosal genotype. Virus-like-particle (VLP)-based immunogens developed recently have proven to be successful as prophylactic HPV vaccines, but are...

    Authors: Carlo Zanotto, Eleana Pozzi, Sole Pacchioni, Massimiliano Bissa, Carlo De Giuli Morghen and Antonia Radaelli
    Citation: Journal of Translational Medicine 2011 9:190
  11. CD8+ effector cells often have an antitumor function in patients with cancer. However, CD8+Foxp3+ regulatory T cells (Tcregs) and interleukin (IL)-17-producing CD8+ T cells (Tc17 cells) also derive from the CD8+ ...

    Authors: Jiang Li, Zhou-Feng Huang, Geng Xiong, Hao-Yuan Mo, Fang Qiu, Hai-Qiang Mai, Qiu-Yan Chen, Jia He, Shu-peng Chen, Li-Min Zheng, Chao-Nan Qian and Yi-Xin Zeng
    Citation: Journal of Translational Medicine 2011 9:189
  12. In the last years human proteomic has represented a promising tool to promote the communication between basic and clinical science.

    Authors: Chiara Baldini, Laura Giusti, Federica Ciregia, Ylenia Da Valle, Camillo Giacomelli, Elena Donadio, Francesco Ferro, Sara Galimberti, Valentina Donati, Laura Bazzichi, Stefano Bombardieri and Antonio Lucacchini
    Citation: Journal of Translational Medicine 2011 9:188
  13. Erythropoietin (EPO) is a glycoprotein hormone which is required to regulate the production of red blood cells. Deficiency of EPO is known to cause anemia in chronically infected renal patients and they requir...

    Authors: Humera Kausar, Sana Gull, Bushra Ijaz, Waqar Ahmad, Muhammad Tahir Sarwar, Zafar Iqbal, Zafar Nawaz, Sheikh Riazuddin and Sajida Hassan
    Citation: Journal of Translational Medicine 2011 9:186
  14. Prostate cancer metastasizes to bone in the majority of patients with advanced disease leading to painfully debilitating fractures, spinal compression and rapid decline. In addition, prostate cancer bone metas...

    Authors: Omer Raheem, Anna A Kulidjian, Christina Wu, Young B Jeong, Tomonori Yamaguchi, Kristen M Smith, Daniel Goff, Heather Leu, Sheldon R Morris, Nicholas A Cacalano, Koichi Masuda, Catriona HM Jamieson, Christopher J Kane and Christina AM Jamieson
    Citation: Journal of Translational Medicine 2011 9:185
  15. Human Leukocyte Antigen (HLA)-E is a non-classical class I HLA molecule that can be stabilized by ligands donated by other classical (HLA-A, -B, -C) and non-classical (HLA-G) family members. HLA-E engages a va...

    Authors: Maria Benevolo, Marcella Mottolese, Elisa Tremante, Francesca Rollo, Maria Grazia Diodoro, Cristiana Ercolani, Isabella Sperduti, Elisa Lo Monaco, Maurizio Cosimelli and Patrizio Giacomini
    Citation: Journal of Translational Medicine 2011 9:184
  16. Chronic refractory angina is a challenging clinical problem with limited treatment options. The results of early cardiovascular stem cell trials using ABMMC have been promising but have utilized intracoronary ...

    Authors: Jorge Tuma, Roberto Fernández-Viña, Antonio Carrasco, Jorge Castillo, Carlos Cruz, Alvaro Carrillo, Jose Ercilla, Carlos Yarleque, Jaime Cunza, Timothy D Henry and Amit N Patel
    Citation: Journal of Translational Medicine 2011 9:183
  17. Idiopathic pulmonary fibrosis represents a lethal form of progressive fibrotic lung disorder with gradually increasing incidence worldwide. Despite intense research efforts its pathogenesis is still elusive an...

    Authors: Argyris Tzouvelekis, George Koliakos, Paschalis Ntolios, Irene Baira, Evangelos Bouros, Anastasia Oikonomou, Athanassios Zissimopoulos, George Kolios, Despoina Kakagia, Vassilis Paspaliaris, Ioannis Kotsianidis, Marios Froudarakis and Demosthenes Bouros
    Citation: Journal of Translational Medicine 2011 9:182
  18. Prolonged life expectancy, life style and environmental changes have caused a changing disease pattern in developed countries towards an increase of degenerative and autoimmune diseases. Stem cells have become...

    Authors: Jeong Chan Ra, Sung Keun Kang, Il Seob Shin, Hyeong Geun Park, Sang Aun Joo, Jeong Geun Kim, Byeong-Cheol Kang, Yong Soon Lee, Ken Nakama, Min Piao, Bertram Sohl and Andras Kurtz
    Citation: Journal of Translational Medicine 2011 9:181
  19. Accumulating evidence supports the role of the mineralocorticoid receptor (MR) in the pathogenesis of diabetic nephropathy. These findings have generated renewed interest in novel MR antagonists with improved ...

    Authors: Rena J Eudy, Vaishali Sahasrabudhe, Kevin Sweeney, Meera Tugnait, Amanda King-Ahmad, Kristen Near, Paula Loria, Mary Ellen Banker, David W Piotrowski and Carine M Boustany-Kari
    Citation: Journal of Translational Medicine 2011 9:180
  20. Cancer patients receiving chemotherapy are at increased risk of thrombosis. Nadroparin has been demonstrated to reduce the incidence of venous and arterial thrombotic events (TEs) by about 50% in cancer outpat...

    Authors: Sandro Barni, Roberto Labianca, Giancarlo Agnelli, Erminio Bonizzoni, Melina Verso, Mario Mandalà, Matteo Brighenti, Fausto Petrelli, Carlo Bianchini, Tania Perrone and Giampietro Gasparini
    Citation: Journal of Translational Medicine 2011 9:179
  21. Ten cancer patients (Six renal cell carcinoma and four breast cancer patients) were treated in a phase I/II study with a vaccine composed of autologous dendritic cells (DCs) and IL-2 to evaluate the DC vaccine...

    Authors: Soyoung Baek, Choung-Soo Kim, Sung-Bae Kim, Yong-man Kim, Seog-Woon Kwon, YongMan Kim, HyunSoo Kim and Hyunah Lee
    Citation: Journal of Translational Medicine 2011 9:178
  22. Tumour cells communicate with the cells of their microenvironment via a series of molecular and cellular interactions to aid their progression to a malignant state and ultimately their metastatic spread. Of th...

    Authors: Thea L Rogers and Ingunn Holen
    Citation: Journal of Translational Medicine 2011 9:177
  23. Fenofibrate, a PPAR alpha agonist, has been widely used in clinics as lipid-regulating agent. PPAR alpha is known to be expressed in many organs including pancreatic beta cells and regulate genes involved in f...

    Authors: Shuai-nan Liu, Quan Liu, Lin-yi Li, Yi Huan, Su-juan Sun and Zhu-fang Shen
    Citation: Journal of Translational Medicine 2011 9:176
  24. Heat shock protein 70 (HSP70) has gained major attention as an adjuvant capable of inducing antigen-specific CD8+ and CD4+ T-cell responses. The ability of HSP70/peptide complexes to elicit cytotoxic T-cell (CTL)...

    Authors: Sabine Tischer, Megan Basila, Britta Maecker-Kolhoff, Stephan Immenschuh, Mathias Oelke, Rainer Blasczyk and Britta Eiz-Vesper
    Citation: Journal of Translational Medicine 2011 9:175
  25. In humans, the role and relationship between molecular pathways that lead to tissue destruction during acute allograft rejection are not fully understood. Based on studies conducted in humans, we recently hypo...

    Authors: Tara L Spivey, Lorenzo Uccellini, Maria Libera Ascierto, Gabriele Zoppoli, Valeria De Giorgi, Lucia Gemma Delogu, Alyson M Engle, Jaime M Thomas, Ena Wang, Francesco M Marincola and Davide Bedognetti
    Citation: Journal of Translational Medicine 2011 9:174
  26. Oncolytic viral tumor therapy is an emerging field in the fight against cancer with rising numbers of clinical trials and the first clinically approved product (Adenovirus for the treatment of Head and Neck Ca...

    Authors: Michael Hess, Jochen Stritzker, Barbara Härtl, Julia B Sturm, Ivaylo Gentschev and Aladar A Szalay
    Citation: Journal of Translational Medicine 2011 9:172
  27. Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with multiple genetic aberrations. Several molecular pathways involved in the regulation of proliferation and cell death are implicated in th...

    Authors: Monica Marra, Ignazio M Sordelli, Angela Lombardi, Monica Lamberti, Luciano Tarantino, Aldo Giudice, Paola Stiuso, Alberto Abbruzzese, Rossella Sperlongano, Marina Accardo, Massimo Agresti, Michele Caraglia and Pasquale Sperlongano
    Citation: Journal of Translational Medicine 2011 9:171
  28. Over 90% of low risk (LR) neuroblastoma patients survive whereas less than 30% of high risk (HR) patients are long term survivors. Age (children younger than 18 months old) is associated with LR disease. Consi...

    Authors: Madhu Gowda, Kamar Godder, Maciej Kmieciak, Andrea Worschech, Maria-Libera Ascierto, Ena Wang, Francesco M Marincola and Masoud H Manjili
    Citation: Journal of Translational Medicine 2011 9:170
  29. Inhibition of the renin-angiotensin-aldosterone system (RAAS) slows down the progression of chronic renal diseases (CKD) including IgA nephropathy (IgAN). Herein, we studied the pathogenetic roles of aldostero...

    Authors: Joseph CK Leung, Loretta YY Chan, Sydney CW Tang, Man-Fai Lam, Chui-Wa Chow, Ai-Ing Lim and Kar-Neng Lai
    Citation: Journal of Translational Medicine 2011 9:169
  30. In head and neck squamous cell carcinoma (HNSCC), expression levels of the epidermal growth factor receptor (EGFR) correlate with poor prognosis and decreased survival rates. As the mechanisms responsible for ...

    Authors: Patrick J Schuler, Petra Boeckers, Rainer Engers, Edwin Boelke, Murat Bas, Jens Greve, Claudia A Dumitru, Goetz F Lehnerdt, Robert L Ferris, Pedro A Andrade Filho, Sven Brandau, Stephan Lang, Theresa L Whiteside and Thomas K Hoffmann
    Citation: Journal of Translational Medicine 2011 9:168
  31. Mutations in SLC26A4 cause Pendred syndrome (hearing loss with goiter) or DFNB4 (non-syndromic hearing loss with inner ear malformation, such as enlarged vestibular aqueduct or Mondini deformity). The relationshi...

    Authors: Shasha Huang, Dongyi Han, Yongyi Yuan, Guojian Wang, Dongyang Kang, Xin Zhang, Xiaofei Yan, Xiaoxiao Meng, Min Dong and Pu Dai
    Citation: Journal of Translational Medicine 2011 9:167
  32. Metastasis-associated in colon cancer-1 (MACC1) is a newly identified gene that plays a role in colon cancer metastasis through upregulation of c-MET proto-oncogene (c-MET). However, the value of MACC1 as a poten...

    Authors: Jiliang Qiu, Pinzhu Huang, Qian Liu, Jian Hong, Binkui Li, Canliang Lu, Li Wang, Jianping Wang and Yunfei Yuan
    Citation: Journal of Translational Medicine 2011 9:166
  33. Autologous bone marrow-derived stem cells have been ascribed an important therapeutic role in No-Option Critical limb Ischemia (NO-CLI). One primary endpoint for evaluating NO-CLI therapy is major amputation (...

    Authors: Eric Benoit, Thomas F O'Donnell Jr, Mark D Iafrati, Enrico Asher, Dennis F Bandyk, John W Hallett, Alan B Lumsden, Gregory J Pearl, Sean P Roddy, Krishnaswami Vijayaraghavan and Amit N Patel
    Citation: Journal of Translational Medicine 2011 9:165
  34. We have shown that insertion of the three vaccinia virus (VACV) promoter-driven foreign gene expression cassettes encoding Renilla luciferase-Aequorea GFP fusion protein, β-galactosidase, and β-glucuronidase into...

    Authors: Nanhai G Chen, Yong A Yu, Qian Zhang and Aladar A Szalay
    Citation: Journal of Translational Medicine 2011 9:164
  35. Metastatic non-small-cell lung cancer (NSCLC) has a dismal prognosis. EGFR is overexpressed or mutated in a large proportion of cases. Downstream components of the EGFR pathway and crosstalk with the NF-κB pat...

    Authors: Mariacarmela Santarpia, Ignacio Magri, Maria Sanchez-Ronco, Carlota Costa, Miguel Angel Molina-Vila, Ana Gimenez-Capitan, Jordi Bertran-Alamillo, Clara Mayo, Susana Benlloch, Santiago Viteri, Amaya Gasco, Nuria Mederos, Enric Carcereny, Miquel Taron and Rafael Rosell
    Citation: Journal of Translational Medicine 2011 9:163
  36. Chronic inflammation has been suggested to favour prostate cancer (PCA) development. Interleukins (IL) represent essential inflammation mediators. IL-2, IL-7, IL-15 and IL-21, sharing a common receptor γ chain...

    Authors: Chantal Mengus, Clémentine Le Magnen, Emanuele Trella, Kawa Yousef, Lukas Bubendorf, Maurizio Provenzano, Alexander Bachmann, Michael Heberer, Giulio C Spagnoli and Stephen Wyler
    Citation: Journal of Translational Medicine 2011 9:162
  37. Autophagy is a dynamic catabolic process characterized by the formation of double membrane vacuoles termed autophagosomes. LC3, a homologue of yeast Atg8, takes part in autophagosome formation, but the exact r...

    Authors: Ting Sun, DanDan Li, LinLin Wang, LiangPing Xia, JianGuo Ma, Zhong Guan, GongKan Feng and XiaoFeng Zhu
    Citation: Journal of Translational Medicine 2011 9:161
  38. The asymptomatic phase of HIV-1 infection is characterized by a progressive depletion of uninfected peripheral effector/memory CD4+ T cells that subsequently leads to immune dysfunction and AIDS symptoms. We h...

    Authors: Antigone K Morou, Filippos Porichis, Elias Krambovitis, George Sourvinos, Demetrios A Spandidos and Alexandros Zafiropoulos
    Citation: Journal of Translational Medicine 2011 9:160
  39. Acute pulmonary embolism (APE) remains a diagnostic challenge due to a variable clinical presentation and the lack of a reliable screening tool. MicroRNAs (miRNAs) regulate gene expression in a wide range of p...

    Authors: Junjie Xiao, Zhi-Cheng Jing, Patrick T Ellinor, Dandan Liang, Hong Zhang, Ying Liu, Xiaoli Chen, Lei Pan, Robert Lyon, Yi Liu, Lu-Ying Peng, Xingqun Liang, Yunfu Sun, Laurentiu M Popescu, Gianluigi Condorelli and Yi-Han Chen
    Citation: Journal of Translational Medicine 2011 9:159
  40. Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors to develop in the digestive tract. These tumors are highly resistant to conventional chemotherapy and only the introduction of i...

    Authors: Luca Da Riva, Fabio Bozzi, Piera Mondellini, Francesca Miccichè, Elena Fumagalli, Elena Vaghi, Eva Tarantino, Veronica Huber, Alessandro Gronchi, Elena Tamborini, Marco A Pierotti, Silvana Pilotti and Italia Bongarzone
    Citation: Journal of Translational Medicine 2011 9:158
  41. Treatment failure for esophageal carcinoma is frequently due to lymph node metastasis and invasion to neighboring organs. The aim of the present study was to investigate invasion- and metastasis-related genes ...

    Authors: Jian Pan, Yan-Fang Tao, Zhuan Zhou, Bang-rong Cao, Shui-Yan Wu, Yan-Lan Zhang, Shao-Yan Hu, Wen-Li Zhao, Jian Wang, Guo-Liang Lou, Zhen Li, Xing Feng and Jian Ni
    Citation: Journal of Translational Medicine 2011 9:157
  42. Downregulation of the putative tumor suppressor gene SLC22A18 has been reported in a number of human cancers. The aim of this study was to investigate the relationship between SLC22A18 downregulation, promoter me...

    Authors: Sheng-Hua Chu, Dong-Fu Feng, Yan-Bin Ma, Hong Zhang, Zhi-An Zhu, Zhi-Qiang Li and Pu-Cha Jiang
    Citation: Journal of Translational Medicine 2011 9:156
  43. Recent positive clinical results in cancer immunotherapy point to the potential of immune-based strategies to provide effective treatment of a variety of cancers. In some patients, the responses to cancer immu...

    Authors: Davide Bedognetti, James M Balwit, Ena Wang, Mary L Disis, Cedrik M Britten, Lucia G Delogu, Sara Tomei, Bernard A Fox, Thomas F Gajewski, Francesco M Marincola and Lisa H Butterfield
    Citation: Journal of Translational Medicine 2011 9:155

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