UNAIDS: AIDS: Epidemic Update: November 2009. 2009, UNAIDS/09.36E/JC1700E
Google Scholar
Barouch DH, Korber B: HIV-1 vaccine development after STEP. Annu Rev Med. 2010, 61: 153-167. 10.1146/annurev.med.042508.093728.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kim JH, Rerks-Ngarm S, Excler JL, Michael NL: HIV vaccines: lessons learned and the way forward. Curr Opin HIV AIDS. 2010, 5: 428-434. 10.1097/COH.0b013e32833d17ac.
Article
PubMed Central
PubMed
Google Scholar
McElrath MJ, Haynes BF: Induction of immunity to human immunodeficiency virus type-1 by vaccination. Immunity. 2010, 33: 542-554. 10.1016/j.immuni.2010.09.011.
Article
PubMed Central
CAS
PubMed
Google Scholar
Walker BD, Burton DR: Toward an AIDS vaccine. Science. 2008, 320: 760-764. 10.1126/science.1152622.
Article
CAS
PubMed
Google Scholar
Barouch DH: Novel adenovirus vector-based vaccines for HIV-1. Curr Opin HIV AIDS. 2010, 5: 386-390. 10.1097/COH.0b013e32833cfe4c.
Article
PubMed Central
PubMed
Google Scholar
Haut LH, Ertl HC: Obstacles to the successful development of an efficacious T cell-inducing HIV-1 vaccine. J Leukoc Biol. 2009, 86: 779-793. 10.1189/jlb.0209094.
Article
CAS
PubMed
Google Scholar
Perrin H, Canderan G, Sekaly RP, Trautmann L: New approaches to design HIV-1 T-cell vaccines. Curr Opin HIV AIDS. 2010, 5: 368-376. 10.1097/COH.0b013e32833d2cc0.
Article
PubMed
Google Scholar
Borrow P, Shattock RJ, Vyakarnam A: Innate immunity against HIV: a priority target for HIV prevention research. Retrovirology. 2010, 7: 84-10.1186/1742-4690-7-84.
Article
PubMed Central
PubMed
Google Scholar
Palucka K, Banchereau J, Mellman I: Designing vaccines based on biology of human dendritic cell subsets. Immunity. 2010, 33: 464-478. 10.1016/j.immuni.2010.10.007.
Article
PubMed Central
CAS
PubMed
Google Scholar
Soghoian DZ, Streeck H: Cytolytic CD4(+) T cells in viral immunity. Expert Rev Vaccines. 2010, 9: 1453-1463. 10.1586/erv.10.132.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tomaras GD, Haynes BF: Strategies for eliciting HIV-1 inhibitory antibodies. Curr Opin HIV AIDS. 2010, 5: 421-427. 10.1097/COH.0b013e32833d2d45.
Article
PubMed Central
PubMed
Google Scholar
Virgin HW, Walker BD: Immunology and the elusive AIDS vaccine. Nature. 2010, 464: 224-231. 10.1038/nature08898.
Article
CAS
PubMed
Google Scholar
Letvin NL, Barouch DH, Montefiori DC: Prospects for vaccine protection against HIV-1 infection and AIDS. Annu Rev Immunol. 2002, 20: 73-99. 10.1146/annurev.immunol.20.081501.094854.
Article
CAS
PubMed
Google Scholar
McElrath MJ: Immune responses to HIV vaccines and potential impact on control of acute HIV-1 infection. J Infect Dis. 2010, 202 (Suppl 2): S323-326.
Article
PubMed Central
PubMed
Google Scholar
McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF: The immune response during acute HIV-1 infection: clues for vaccine development. Nat Rev Immunol. 2010, 10: 11-23. 10.1038/nri2674.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, Chiu J, Paris R, Premsri N, Namwat C, de Souza M, Adams E: Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med. 2009, 361: 2209-2220. 10.1056/NEJMoa0908492.
Article
CAS
PubMed
Google Scholar
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA: Mechanisms of MHC class I-restricted antigen processing and cross-presentation. Immunol Rev. 2005, 207: 145-157. 10.1111/j.0105-2896.2005.00316.x.
Article
CAS
PubMed
Google Scholar
Hansen TH, Bouvier M: MHC class I antigen presentation: learning from viral evasion strategies. Nat Rev Immunol. 2009, 9: 503-513. 10.1038/nri2575.
Article
CAS
PubMed
Google Scholar
Loureiro J, Ploegh HL: Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions. Adv Immunol. 2006, 92: 225-305.
Article
CAS
PubMed
Google Scholar
Vyas JM, Van der Veen AG, Ploegh HL: The known unknowns of antigen processing and presentation. Nat Rev Immunol. 2008, 8: 607-618. 10.1038/nri2368.
Article
PubMed Central
CAS
PubMed
Google Scholar
Choudhuri K, van der Merwe PA: Molecular mechanisms involved in T cell receptor triggering. Semin Immunol. 2007, 19: 255-261. 10.1016/j.smim.2007.04.005.
Article
CAS
PubMed
Google Scholar
Godfrey DI, Rossjohn J, McCluskey J: The fidelity, occasional promiscuity, and versatility of T cell receptor recognition. Immunity. 2008, 28: 304-314. 10.1016/j.immuni.2008.02.004.
Article
CAS
PubMed
Google Scholar
van der Merwe PA, Dushek O: Mechanisms for T cell receptor triggering. Nat Rev Immunol. 2010, 11: 47-55.
Article
PubMed
Google Scholar
Fischer W, Ganusov VV, Giorgi EE, Hraber PT, Keele BF, Leitner T, Han CS, Gleasner CD, Green L, Lo CC: Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing. PLoS One. 2010, 5: e12303-10.1371/journal.pone.0012303.
Article
PubMed Central
PubMed
Google Scholar
Korber BT, Letvin NL, Haynes BF: T-cell vaccine strategies for human immunodeficiency virus, the virus with a thousand faces. J Virol. 2009, 83: 8300-8314. 10.1128/JVI.00114-09.
Article
PubMed Central
CAS
PubMed
Google Scholar
McCutchan FE: Understanding the genetic diversity of HIV-1. AIDS. 2000, 14 (Suppl 3): S31-44.
CAS
PubMed
Google Scholar
Wood N, Bhattacharya T, Keele BF, Giorgi E, Liu M, Gaschen B, Daniels M, Ferrari G, Haynes BF, McMichael A: HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC. PLoS Pathog. 2009, 5: e1000414-10.1371/journal.ppat.1000414.
Article
PubMed Central
PubMed
Google Scholar
De Groot AS, Marcon L, Bishop EA, Rivera D, Kutzler M, Weiner DB, Martin W: HIV vaccine development by computer assisted design: the GAIA vaccine. Vaccine. 2005, 23: 2136-2148. 10.1016/j.vaccine.2005.01.097.
Article
CAS
PubMed
Google Scholar
Doria-Rose NA, Learn GH, Rodrigo AG, Nickle DC, Li F, Mahalanabis M, Hensel MT, McLaughlin S, Edmonson PF, Montefiori D: Human immunodeficiency virus type 1 subtype B ancestral envelope protein is functional and elicits neutralizing antibodies in rabbits similar to those elicited by a circulating subtype B envelope. J Virol. 2005, 79: 11214-11224. 10.1128/JVI.79.17.11214-11224.2005.
Article
PubMed Central
CAS
PubMed
Google Scholar
Earl PL, Cotter C, Moss B, VanCott T, Currier J, Eller LA, McCutchan F, Birx DL, Michael NL, Marovich MA: Design and evaluation of multi-gene, multi-clade HIV-1 MVA vaccines. Vaccine. 2009, 27: 5885-5895. 10.1016/j.vaccine.2009.07.039.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fischer W, Perkins S, Theiler J, Bhattacharya T, Yusim K, Funkhouser R, Kuiken C, Haynes B, Letvin NL, Walker BD: Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants. Nat Med. 2007, 13: 100-106. 10.1038/nm1461.
Article
CAS
PubMed
Google Scholar
Gao F, Weaver EA, Lu Z, Li Y, Liao HX, Ma B, Alam SM, Scearce RM, Sutherland LL, Yu JS: Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoprotein. J Virol. 2005, 79: 1154-1163. 10.1128/JVI.79.2.1154-1163.2005.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gaschen B, Taylor J, Yusim K, Foley B, Gao F, Lang D, Novitsky V, Haynes B, Hahn BH, Bhattacharya T, Korber B: Diversity considerations in HIV-1 vaccine selection. Science. 2002, 296: 2354-2360. 10.1126/science.1070441.
Article
CAS
PubMed
Google Scholar
Gorse GJ, Baden LR, Wecker M, Newman MJ, Ferrari G, Weinhold KJ, Livingston BD, Villafana TL, Li H, Noonan E, Russell ND: Safety and immunogenicity of cytotoxic T-lymphocyte poly-epitope, DNA plasmid (EP HIV-1090) vaccine in healthy, human immunodeficiency virus type 1 (HIV-1)-uninfected adults. Vaccine. 2008, 26: 215-223. 10.1016/j.vaccine.2007.10.061.
Article
CAS
PubMed
Google Scholar
Hanke T, McMichael AJ: Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat Med. 2000, 6: 951-955. 10.1038/79626.
Article
CAS
PubMed
Google Scholar
Livingston BD, Newman M, Crimi C, McKinney D, Chesnut R, Sette A: Optimization of epitope processing enhances immunogenicity of multiepitope DNA vaccines. Vaccine. 2001, 19: 4652-4660. 10.1016/S0264-410X(01)00233-X.
Article
CAS
PubMed
Google Scholar
Nickle DC, Jensen MA, Gottlieb GS, Shriner D, Learn GH, Rodrigo AG, Mullins JI: Consensus and ancestral state HIV vaccines. Science. 2003, 299: 1515-1518. author reply 1515-1518
Article
CAS
PubMed
Google Scholar
Nickle DC, Rolland M, Jensen MA, Pond SL, Deng W, Seligman M, Heckerman D, Mullins JI, Jojic N: Coping with viral diversity in HIV vaccine design. PLoS Comput Biol. 2007, 3: e75-10.1371/journal.pcbi.0030075.
Article
PubMed Central
PubMed
Google Scholar
Rolland M, Nickle DC, Mullins JI: HIV-1 group M conserved elements vaccine. PLoS Pathog. 2007, 3: e157-10.1371/journal.ppat.0030157.
Article
PubMed Central
PubMed
Google Scholar
Thomson SA, Jaramillo AB, Shoobridge M, Dunstan KJ, Everett B, Ranasinghe C, Kent SJ, Gao K, Medveckzy J, Ffrench RA, Ramshaw IA: Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use. Vaccine. 2005, 23: 4647-4657. 10.1016/j.vaccine.2005.04.045.
Article
CAS
PubMed
Google Scholar
Brander C, Frahm N, Walker BD: The challenges of host and viral diversity in HIV vaccine design. Curr Opin Immunol. 2006, 18: 430-437. 10.1016/j.coi.2006.05.012.
Article
CAS
PubMed
Google Scholar
Frahm N, Kiepiela P, Adams S, Linde CH, Hewitt HS, Sango K, Feeney ME, Addo MM, Lichterfeld M, Lahaie MP: Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes. Nat Immunol. 2006, 7: 173-178. 10.1038/ni1281.
Article
CAS
PubMed
Google Scholar
Frahm N, Korber BT, Adams CM, Szinger JJ, Draenert R, Addo MM, Feeney ME, Yusim K, Sango K, Brown NV: Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. J Virol. 2004, 78: 2187-2200. 10.1128/JVI.78.5.2187-2200.2004.
Article
PubMed Central
CAS
PubMed
Google Scholar
Geldmacher C, Currier JR, Herrmann E, Haule A, Kuta E, McCutchan F, Njovu L, Geis S, Hoffmann O, Maboko L: CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients. J Virol. 2007, 81: 2440-2448. 10.1128/JVI.01847-06.
Article
PubMed Central
CAS
PubMed
Google Scholar
Goonetilleke N, Liu MK, Salazar-Gonzalez JF, Ferrari G, Giorgi E, Ganusov VV, Keele BF, Learn GH, Turnbull EL, Salazar MG: The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J Exp Med. 2009, 206: 1253-1272. 10.1084/jem.20090365.
Article
PubMed Central
CAS
PubMed
Google Scholar
Liu Y, McNevin JP, Holte S, McElrath MJ, Mullins JI: Dynamics of viral evolution and CTL responses in HIV-1 infection. PLoS One. 2011, 6: e15639-10.1371/journal.pone.0015639.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rolland M, Heckerman D, Deng W, Rousseau CM, Coovadia H, Bishop K, Goulder PJ, Walker BD, Brander C, Mullins JI: Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads. PLoS One. 2008, 3: e1424-10.1371/journal.pone.0001424.
Article
PubMed Central
PubMed
Google Scholar
Goepfert PA, Lumm W, Farmer P, Matthews P, Prendergast A, Carlson JM, Derdeyn CA, Tang J, Kaslow RA, Bansal A: Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients. J Exp Med. 2008, 205: 1009-1017. 10.1084/jem.20072457.
Article
PubMed Central
CAS
PubMed
Google Scholar
Honeyborne I, Prendergast A, Pereyra F, Leslie A, Crawford H, Payne R, Reddy S, Bishop K, Moodley E, Nair K: Control of Hiv-1 Is Associated with Hla-B*13 and Targeting of Multiple Gag-Specific Cd8+ T Cell Epitopes. J Virol. 2007
Google Scholar
Liu J, O'Brien KL, Lynch DM, Simmons NL, La Porte A, Riggs AM, Abbink P, Coffey RT, Grandpre LE, Seaman MS: Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys. Nature. 2009, 457: 87-91. 10.1038/nature07469.
Article
PubMed Central
CAS
PubMed
Google Scholar
Thurmond J, Yoon H, Kuiken C, Yusim K, Perkins S, Theiler J, Bhattacharya T, Korber B, Fischer W: Web-based design and evaluation of T-cell vaccine candidates. Bioinformatics. 2008, 24: 1639-1640. 10.1093/bioinformatics/btn251.
Article
CAS
PubMed
Google Scholar
Currier JR, Ngauy V, de Souza MS, Ratto-Kim S, Cox JH, Polonis VR, Earl P, Moss B, Peel S, Slike B: Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidate. PLoS One. 2010, 5: e13983-10.1371/journal.pone.0013983.
Article
PubMed Central
PubMed
Google Scholar
Altfeld M, Allen TM, Yu XG, Johnston MN, Agrawal D, Korber BT, Montefiori DC, O'Connor DH, Davis BT, Lee PK: HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus. Nature. 2002, 420: 434-439. 10.1038/nature01200.
Article
CAS
PubMed
Google Scholar
Barouch DH, O'Brien KL, Simmons NL, King SL, Abbink P, Maxfield LF, Sun YH, La Porte A, Riggs AM, Lynch DM: Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys. Nat Med. 2010, 16: 319-323. 10.1038/nm.2089.
Article
PubMed Central
CAS
PubMed
Google Scholar
Santra S, Liao HX, Zhang R, Muldoon M, Watson S, Fischer W, Theiler J, Szinger J, Balachandran H, Buzby A: Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys. Nat Med. 2010, 16: 324-328. 10.1038/nm.2108.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kiepiela P, Leslie AJ, Honeyborne I, Ramduth D, Thobakgale C, Chetty S, Rathnavalu P, Moore C, Pfafferott KJ, Hilton L: Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature. 2004, 432: 769-775. 10.1038/nature03113.
Article
CAS
PubMed
Google Scholar
Kiepiela P, Ngumbela K, Thobakgale C, Ramduth D, Honeyborne I, Moodley E, Reddy S, de Pierres C, Mncube Z, Mkhwanazi N: CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Nat Med. 2007, 13: 46-53. 10.1038/nm1520.
Article
CAS
PubMed
Google Scholar
Leslie A, Kavanagh D, Honeyborne I, Pfafferott K, Edwards C, Pillay T, Hilton L, Thobakgale C, Ramduth D, Draenert R: Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA. J Exp Med. 2005, 201: 891-902. 10.1084/jem.20041455.
Article
PubMed Central
CAS
PubMed
Google Scholar
Leslie A, Price DA, Mkhize P, Bishop K, Rathod A, Day C, Crawford H, Honeyborne I, Asher TE, Luzzi G: Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype. J Immunol. 2006, 177: 4699-4708.
Article
CAS
PubMed
Google Scholar
Leslie AJ, Pfafferott KJ, Chetty P, Draenert R, Addo MM, Feeney M, Tang Y, Holmes EC, Allen T, Prado JG: HIV evolution: CTL escape mutation and reversion after transmission. Nat Med. 2004, 10: 282-289. 10.1038/nm992.
Article
CAS
PubMed
Google Scholar
Goulder PJ, Brander C, Tang Y, Tremblay C, Colbert RA, Addo MM, Rosenberg ES, Nguyen T, Allen R, Trocha A: Evolution and transmission of stable CTL escape mutations in HIV infection. Nature. 2001, 412: 334-338. 10.1038/35085576.
Article
CAS
PubMed
Google Scholar
Kelleher AD, Long C, Holmes EC, Allen RL, Wilson J, Conlon C, Workman C, Shaunak S, Olson K, Goulder P: Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. J Exp Med. 2001, 193: 375-386. 10.1084/jem.193.3.375.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sandstrom E, Nilsson C, Hejdeman B, Brave A, Bratt G, Robb M, Cox J, Vancott T, Marovich M, Stout R: Broad immunogenicity of a multigene, multiclade HIV-1 DNA vaccine boosted with heterologous HIV-1 recombinant modified vaccinia virus Ankara. J Infect Dis. 2008, 198: 1482-1490. 10.1086/592507.
Article
PubMed
Google Scholar
Catanzaro AT, Koup RA, Roederer M, Bailer RT, Enama ME, Moodie Z, Gu L, Martin JE, Novik L, Chakrabarti BK: Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector. J Infect Dis. 2006, 194: 1638-1649. 10.1086/509258.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kibuuka H, Kimutai R, Maboko L, Sawe F, Schunk MS, Kroidl A, Shaffer D, Eller LA, Kibaya R, Eller MA: A phase 1/2 study of a multiclade HIV-1 DNA plasmid prime and recombinant adenovirus serotype 5 boost vaccine in HIV-Uninfected East Africans (RV 172). J Infect Dis. 2010, 201: 600-607. 10.1086/650299.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F: Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature. 2010, 467: 591-595. 10.1038/nature09385.
Article
PubMed Central
CAS
PubMed
Google Scholar
Schwickert TA, Victora GD, Fooksman DR, Kamphorst AO, Mugnier MR, Gitlin AD, Dustin ML, Nussenzweig MC: A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. J Exp Med. 2011, 208: 1243-1252. 10.1084/jem.20102477.
Article
PubMed Central
CAS
PubMed
Google Scholar
Victora GD, Schwickert TA, Fooksman DR, Kamphorst AO, Meyer-Hermann M, Dustin ML, Nussenzweig MC: Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell. 2010, 143: 592-605. 10.1016/j.cell.2010.10.032.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wu X, Yang ZY, Li Y, Hogerkorp CM, Schief WR, Seaman MS, Zhou T, Schmidt SD, Wu L, Xu L: Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science. 2010, 329: 856-861. 10.1126/science.1187659.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, Coyne-Johnson L, Whizin N, Oswald K, Shoemaker R, Swanson T: Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature. 2011, 473: 523-527. 10.1038/nature10003.
Article
PubMed Central
CAS
PubMed
Google Scholar
Koup RA, Roederer M, Lamoreaux L, Fischer J, Novik L, Nason MC, Larkin BD, Enama ME, Ledgerwood JE, Bailer RT: Priming immunization with DNA augments immunogenicity of recombinant adenoviral vectors for both HIV-1 specific antibody and T-cell responses. PLoS One. 2010, 5: e9015-10.1371/journal.pone.0009015.
Article
PubMed Central
PubMed
Google Scholar