Skip to main content
Figure 1 | Journal of Translational Medicine

Figure 1

From: Defining epitope coverage requirements for T cell-based HIV vaccines: Theoretical considerations and practical applications

Figure 1

Epitope coverage for four Gag and Env natural sequence products. Epitope coverage analysis (exact 10-mer window matching) is shown for four different natural sequence Gag and Env protein-based vaccine products. Mean coverage of the global HIV-1 group M Gag (3585 sequences) and Env (2258 sequences) datasets obtained from the LANL HIV Database is shown as a percentage of the possible incoming isolates for which there would be an exact match at any 10-mer window (Panels A and B). Green bars represent the mono-valent Gag and Env sequences, while the blue, pink and red bars represent all possible di-valent, tri-valent and tetra-valent formations of the four individual products respectively. Based upon this analysis, the coverage that each formulation would provide was calculated and plotted for up to 20 T cell epitopes (Panels C and D). Color coding of the lines matches panels A and B above (green for mono-valent, blue for di-valent, pink for tri-valent and red for tetra-valent). The point at which each formulation achieves 90% coverage of all isolates in the LANL database is denoted by the dotted line.

Back to article page