Figure 2

Calculation of minimum epitope coverage requirements. Interpolation of the required minimum epitope count for achieving 90% isolate coverage for mono-valent subtype A and tetra-valent vaccine formulations (ACDE) is shown for Gag (Panel A) and Env (Panel B). Calculated minimum epitope counts required to achieve 90% coverage all isolates in the LANL database is shown as a bar graph for Gag (Panel C) and Env (Panel D). Color coding of the bars matches Figure 1 above (green for mono-valent, blue for di-valent, pink for tri-valent and red for tetra-valent).