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  1. CD4+CD25+ regulatory T lymphocytes (TR) constitute 5–10% of peripheral CD4+ T cells in naive mice and humans, and play an important role in controlling immune responses. Accumulating evidences show that TR cells ...

    Authors: Ji-Yan Liu, Xiao-Shi Zhang, Ya Ding, Rui-Qing Peng, Xia Cheng, Nian-Hua Zhang, Jian-Chuan Xia and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2005 3:5

    Content type: Research

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  2. Metastatic, chemotherapy-resistant melanoma is an intractable cancer with a very poor prognosis. As to immunotherapy targeting metastatic melanoma, HLA-A2+ patients were mainly enrolled in the study in Western co...

    Authors: Yasuto Akiyama, Ryuji Tanosaki, Naoki Inoue, Makiko Shimada, Yukie Hotate, Akifumi Yamamoto, Naoya Yamazaki, Ichiro Kawashima, Ikuei Nukaya, Kazutoh Takesako, Kouji Maruyama, Yoichi Takaue and Ken Yamaguchi

    Citation: Journal of Translational Medicine 2005 3:4

    Content type: Research

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  3. Spontaneous T cell responses against specific tumor-associated antigens (TAA) are frequently detected in peripheral blood of tumor patients of various histiotypes. However, little is known about whether these ...

    Authors: Dirk Nagorsen, Carmen Scheibenbogen, Anne Letsch, Christoph-Thomas Germer, Heinz-Johannes Buhr, Susanna Hegewisch-Becker, Licia Rivoltini, Eckhard Thiel and Ulrich Keilholz

    Citation: Journal of Translational Medicine 2005 3:3

    Content type: Research

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  4. Synovial sarcoma is a high-grade malignant tumor of soft tissue, characterized by the specific chromosomal translocation t(X;18), and its resultant SYT-SSX fusion gene. Despite intensive multimodality therapy,...

    Authors: Satoshi Kawaguchi, Takuro Wada, Kazunori Ida, Yuriko Sato, Satoshi Nagoya, Tomohide Tsukahara, Sigeharu Kimura, Hiroeki Sahara, Hideyuki Ikeda, Kumiko Shimozawa, Hiroko Asanuma, Toshihiko Torigoe, Hiroaki Hiraga, Takeshi Ishii, Shin-ichiro Tatezaki, Noriyuki Sato…

    Citation: Journal of Translational Medicine 2005 3:1

    Content type: Research

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  5. Forty to eighty percent of melanoma tumors have activating mutations in BRAF although the clinical importance of these mutations is not clear. We previously reported an analysis of BRAF mutations in metastatic me...

    Authors: David Z Chang, Katherine S Panageas, Iman Osman, David Polsky, Klaus Busam and Paul B Chapman

    Citation: Journal of Translational Medicine 2004 2:46

    Content type: Research

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  6. Immunosuppression is documented in several malignant diseases, including breast cancer. Subsequently, future therapeutic concepts might include immunological approaches. However, detailed knowledge about tumor...

    Authors: Jana M Schüle, Leif Bergkvist, Leif Håkansson, Bertil Gustafsson and Annika Håkansson

    Citation: Journal of Translational Medicine 2004 2:45

    Content type: Research

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  7. Walking along disease-associated protein sequences in the search for specific segments able to induce cellular immune response may direct clinical research towards effective peptide-based vaccines. To this aim...

    Authors: Alberta Lucchese, Abraham Mittelman, Mong-Shang Lin, Darja Kanduc and Animesh A Sinha

    Citation: Journal of Translational Medicine 2004 2:43

    Content type: Research

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  8. Tumors and viruses have developed many mechanisms to evade the immune system, including down-regulation of target antigens and MHC molecules. These immune escape mechanisms may be able to be circumvented by ad...

    Authors: Alexander Langerman, Glenda G Callender and Michael I Nishimura

    Citation: Journal of Translational Medicine 2004 2:42

    Content type: Research

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  9. T cell-mediated cancer immunotherapy is dose dependent and optimally requires participation of antigen-specific CD4+ and CD8+ T cells. Here, we isolated tumor-sensitized T cells and activated them in vitro using ...

    Authors: Li-Xin Wang, Wen-Xin Huang, Hallie Graor, Peter A Cohen, Julian A Kim, Suyu Shu and Gregory E Plautz

    Citation: Journal of Translational Medicine 2004 2:41

    Content type: Research

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  10. A novel tyrosine kinase receptor EphA2 is expressed at high levels in advanced and metastatic cancers. We examined whether vaccinations with synthetic mouse EphA2 (mEphA2)-derived peptides that serve as T cell...

    Authors: Manabu Hatano, Naruo Kuwashima, Tomohide Tatsumi, Jill E Dusak, Fumihiko Nishimura, Karlyne M Reilly, Walter J Storkus and Hideho Okada

    Citation: Journal of Translational Medicine 2004 2:40

    Content type: Research

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  11. Over the past decade RNA interference (RNAi) has emerged as a natural mechanism for silencing gene expression. This ancient cellular antiviral response can be exploited to allow specific inhibition of the func...

    Authors: Simone Mocellin and Maurizio Provenzano

    Citation: Journal of Translational Medicine 2004 2:39

    Content type: Review

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  12. D-dimer is considered a marker of hypercoagulable state and of endogenous fibrinolysis, so increased d-dimer is detectable in patients affected by thrombosis. Yet, several studies showed that also infertility,...

    Authors: Pierpaolo Di Micco, Maristella D'Uva, Ida Strina, Antonio Mollo, Valeria Amato, Alferio Niglio and Giuseppe De Placido

    Citation: Journal of Translational Medicine 2004 2:38

    Content type: Research

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  13. During cytotoxic lymphocyte (CL) mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well wit...

    Authors: Nigel J Waterhouse, Karin A Sedelies and Chris JP Clarke

    Citation: Journal of Translational Medicine 2004 2:36

    Content type: Commentary

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  14. Human metastatic cutaneous melanoma has gained a well deserved reputation for its immune responsiveness. The reason(s) remain(s) unknown. We attempted previously to characterize several variables that may affe...

    Authors: Ena Wang, Monica C Panelli, Katia Zavaglia, Susanna Mandruzzato, Nan Hu, Phil R Taylor, Barbara Seliger, Paola Zanovello, Ralph S Freedman and Francesco M Marincola

    Citation: Journal of Translational Medicine 2004 2:34

    Content type: Research

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  15. Past studies suggested that tumor necrosis factor (TNF) assisted anti-tumor treatment and intensified the sensitivity of chemotherapy. However its clinical application has been curbed because of its low purity...

    Authors: Xing Liu, Xiang-fu Zhang, Zhi-weng Zheng, Huishan Lu, Xinyuan Wu, Changmin Huang, Chuan Wang and Guoxiang Guang

    Citation: Journal of Translational Medicine 2004 2:33

    Content type: Research

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  16. Recently BRCA1 has been implicated in the regulation of gene expression from the X chromosome. In this study the influence of BRCA1 on expression of X chromosome genes was investigated. Complementary DNA micro...

    Authors: Amir A Jazaeri, Gadisetti VR Chandramouli, Olga Aprelikova, Ulrike A Nuber, Christos Sotiriou, Edison T Liu, H Hilger Ropers, Cindy J Yee, Jeff Boyd and J Carl Barrett

    Citation: Journal of Translational Medicine 2004 2:32

    Content type: Research

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  17. This study assessed the Granzyme B (GrB) ELISPOT as a viable alternative to the 51Cr-release assay for measuring cytotoxic activity of innate immune effector cells. We strategically selected the GrB ELISPOT assay...

    Authors: Kimberly A Shafer-Weaver, Thomas Sayers, Douglas B Kuhns, Susan L Strobl, Mark W Burkett, Michael Baseler and Anatoli Malyguine

    Citation: Journal of Translational Medicine 2004 2:31

    Content type: Methodology

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  18. Sequence-based typing (SBT) is one of the most comprehensive methods utilized for HLA typing. However, one of the inherent problems with this typing method is the interpretation of ambiguous allele combination...

    Authors: Sharon D Adams, Kathleen C Barracchini, Deborah Chen, FuMeei Robbins, Lu Wang, Paula Larsen, Robert Luhm and David F Stroncek

    Citation: Journal of Translational Medicine 2004 2:30

    Content type: Research

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  19. Prostate-specific membrane antigen (PSMA) is a well characterized prostate-specific tumor associated antigen. Its expression is elevated in prostate carcinoma, particularly in metastatic and recurrent lesions....

    Authors: Jiaqiang Ren, Li Zheng, Qi Chen, Hua Li, Lin Zhang and Hongguang Zhu

    Citation: Journal of Translational Medicine 2004 2:29

    Content type: Research

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  20. Translational research requires a team approach to scientific inquiry and product development. Translational research teams consist of basic and clinical scientists who can be members of both academic and indu...

    Authors: Malcolm R Parks and Mary L Disis

    Citation: Journal of Translational Medicine 2004 2:28

    Content type: Commentary

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  21. Dendritic Cell (DC) vaccination is a very promising therapeutic strategy in cancer patients. The immunizing ability of DC is critically influenced by their migration activity to lymphatic tissues, where they h...

    Authors: Ruggero Ridolfi, Angela Riccobon, Riccardo Galassi, Gianluigi Giorgetti, Massimiliano Petrini, Laura Fiammenghi, Monica Stefanelli, Laura Ridolfi, Andrea Moretti, Giuseppe Migliori and Giuseppe Fiorentini

    Citation: Journal of Translational Medicine 2004 2:27

    Content type: Research

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  22. The hypothesis that human cancers express antigens that can be specifically targeted by cell mediated immunity has become a scientifically justifiable rationale for the design and clinical testing of novel tum...

    Authors: Maurizio Chiriva-Internati, Fabio Grizzi, Robert K Bright and W Martin Kast

    Citation: Journal of Translational Medicine 2004 2:26

    Content type: Commentary

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  23. The administration of granulocyte colony-stimulating factor (G-CSF) to peripheral blood progenitor cell (PBPC) donors causes spleen length to increase, but the duration of enlargement is not known. Eighteen he...

    Authors: David F Stroncek, Kristin Dittmar, Thomas Shawker, Angela Heatherman and Susan F Leitman

    Citation: Journal of Translational Medicine 2004 2:25

    Content type: Research

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  24. Nasopharyngeal carcinoma (NPC) is characterized by a high prevalence in Southern China, especially among Cantonese individuals of the Guangdong Province. Epidemiological studies have suggested that frequent ex...

    Authors: Ju-Hong Jiang, Wei-Hua Jia, Han-Kui Chen, Bing-Jian Feng, Hai-De Qin, Zhi-Gang Pan, Guo-Ping Shen, Li-Xi Huang, Qi-Sheng Feng, Li-Zhen Chen, Dong-Xin Lin and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2004 2:24

    Content type: Research

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  25. With the role of angiogenesis in tumor growth and progression firmly established, considerable effort has been directed to antiangiogenic therapy as a new modality to treat human cancers. Antiangiogenic agents...

    Authors: Anita Tandle, Dan G Blazer III and Steven K Libutti

    Citation: Journal of Translational Medicine 2004 2:22

    Content type: Review

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  26. Survivin is a member of the inhibitor of apoptosis protein (IAP) family containing a single baculovirus IAP repeat domain. It is expressed during fetal development but becomes undetectable in terminally differ...

    Authors: Tetsuhiro Tsuruma, Fumitake Hata, Toshihiko Torigoe, Tomohisa Furuhata, Satomi Idenoue, Takehiro Kurotaki, Masaaki Yamamoto, Atsuhito Yagihashi, Tosei Ohmura, Koji Yamaguchi, Tadashi Katsuramaki, Takahiro Yasoshima, Kazuaki Sasaki, Yasuhiro Mizushima, Hidetoshi Minamida, Hiromichi Kimura…

    Citation: Journal of Translational Medicine 2004 2:19

    Content type: Research

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  27. Extensive clinical experience has shown that systemic interleukin (IL)-2 administration can induce complete or partial regression of renal cell cancer (RCC) metastases in 15 to 20 % of patients. Since IL-2 has...

    Authors: Monica C Panelli, Richard White, Mareva Foster, Brian Martin, Ena Wang, Kina Smith and Francesco M Marincola

    Citation: Journal of Translational Medicine 2004 2:17

    Content type: Research

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  28. The endotelin (ET) axis, that includes ET-1, ET-2, ET-3, and the ET receptors, ETA and ETB, plays an important physiological role, as modulator of vasomotor tone, tissue differentiation and development, cell prol...

    Authors: Anna Bagnato and Pier Giorgio Natali

    Citation: Journal of Translational Medicine 2004 2:16

    Content type: Review

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  29. CD8+ T cell responses are known to be important to the control of HIV-1 infection. While responses to reverse transcriptase and most structural and accessory proteins have been extensively studied, CD8 T cell ...

    Authors: William R Rodriguez, Marylyn M Addo, Almas Rathod, Cecily A Fitzpatrick, Xu G Yu, Beth Perkins, Eric S Rosenberg, Marcus Altfeld and Bruce D Walker

    Citation: Journal of Translational Medicine 2004 2:15

    Content type: Research

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  30. When we launched the Journal of Translational Medicine a few months ago, we were interested primarily in exploring scientific consideration of this discipline. However, as editors of JTM, we have been contacted a...

    Authors: Stacey P Mankoff, Christian Brander, Soldano Ferrone and Francesco M Marincola

    Citation: Journal of Translational Medicine 2004 2:14

    Content type: Commentary

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  31. We assessed the incidence of micro-metastases at surgical margins (SM) and pelvic lymph nodes (LN) in patients submitted to radical retropubic prostatectomy (RP) after neoadjuvant therapy (NT) or to RP alone. ...

    Authors: Marco Grasso, Caterina Lania, Salvatore Blanco, Marco Baruffi and Simone Mocellin

    Citation: Journal of Translational Medicine 2004 2:13

    Content type: Research

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  32. Cells of the immune system spontaneously recognize autologous tumor cells and T cells are believed to be the main effector cells for the immune surveillance of cancer. Recent advances in our understanding of b...

    Authors: Per thor Straten, David Schrama, Mads Hald Andersen and Jürgen C Becker

    Citation: Journal of Translational Medicine 2004 2:11

    Content type: Review

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  33. Nasopharyngeal carcinoma (NPC) is one of the most commons cancers in Southeast Asia and Southern China. Several NPC-associated genes have been so far described and here we describe the identification and the c...

    Authors: Feng Li, Xu Y Yang, Wei H Jiang, Zhi H Yin, Xiang L Feng, Wei D Liu, Lei Wang, Wen Zhou, Cai P Ren and Kai T Yao

    Citation: Journal of Translational Medicine 2004 2:10

    Content type: Research

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  34. The desired outcome of cancer vaccination is to induce a potent T cell response which can specifically recognize and eliminate autologous tumor cells in vivo. Accordingly, immunological assays that demonstrate re...

    Authors: Anatoli Malyguine, Susan L Strobl, Kimberly A Shafer-Weaver, Tracy Ulderich, Angela Troke, Michael Baseler, Larry W Kwak and Sattva S Neelapu

    Citation: Journal of Translational Medicine 2004 2:9

    Content type: Methodology

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  35. Genes in the Leukocyte Antigen 6 (Ly-6) superfamily encode glycosyl-phosphatidylinositol (GPI) anchored glycoproteins (gp) with conserved domains of 70 to 100 amino acids and 8 to 10 cysteine residues. Murine Ly-...

    Authors: David F Stroncek, Lorraine Caruccio and Maria Bettinotti

    Citation: Journal of Translational Medicine 2004 2:8

    Content type: Review

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  36. Congenital thrombotic risk factors, oncological diseases and its therapies have been related to an increased occurrence of upper extremities deep venous thrombosis (UEDVT).

    Authors: Pierpaolo Di Micco, Alferio Niglio, Amalia De Renzo, Anna Lucania, Rosanna Di Fiore, Olga Scudiero and Giuseppe Castaldo

    Citation: Journal of Translational Medicine 2004 2:7

    Content type: Research

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  37. Osteoclasts are cells of hematopoietic origin with a unique property of dissolving bone; their inhibition is a principle for treatment of diseases of bone loss. Protocols for generation of human osteoclasts in...

    Authors: Mira Susa, Ngoc-Hong Luong-Nguyen, David Cappellen, Natasa Zamurovic and Rainer Gamse

    Citation: Journal of Translational Medicine 2004 2:6

    Content type: Methodology

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  38. Reliable quantitative evaluation of molecular pathways is critical for both drug discovery and treatment monitoring. We have modified the CAM assay to quantitatively measure vascular density, endothelial proli...

    Authors: Walter J Miller, Mark L Kayton, Angela Patton, Sarah O'Connor, Mei He, Huan Vu, Galina Baibakov, Dominique Lorang, Vladimir Knezevic, Elise Kohn, H Richard Alexander, David Stirling, Faribourz Payvandi, George W Muller and Steven K Libutti

    Citation: Journal of Translational Medicine 2004 2:4

    Content type: Research

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