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Page 132 of 138

  1. The unique features of human embryonic stem (hES) cells make them the best candidate resource for both cell replacement therapy and development research. However, the molecular mechanisms responsible for the s...

    Authors: Jiaqiang Ren, Ping Jin, Ena Wang, Francesco M Marincola and David F Stroncek
    Citation: Journal of Translational Medicine 2009 7:20
  2. Tetrapyrrole molecules are distributed in virtually all living organisms on Earth. In mammals, tetrapyrrole end products are closely linked to oxygen metabolism. Since increasingly complex trophic functional s...

    Authors: Jose-Ignacio Arias, María-Angeles Aller and Jaime Arias
    Citation: Journal of Translational Medicine 2009 7:19
  3. Optimal techniques for DC generation for immunotherapy in cancer are yet to be established. Study aims were to evaluate: (i) DC activation/maturation milieu (TNF-α +/- IFN-α) and its effects on CD8+ hTERT-specifi...

    Authors: Mark M Aloysius, Alastair J Mc Kechnie, Richard A Robins, Chandan Verma, Jennifer M Eremin, Farzin Farzaneh, Nagy A Habib, Joti Bhalla, Nicola R Hardwick, Sukchai Satthaporn, Thiagarajan Sreenivasan, Mohammed El-Sheemy and Oleg Eremin
    Citation: Journal of Translational Medicine 2009 7:18
  4. The Receptor for Advanced Glycation Endproducts [RAGE] is an evolutionarily recent member of the immunoglobulin super-family, encoded in the Class III region of the major histocompatability complex. RAGE is hi...

    Authors: Louis J Sparvero, Denise Asafu-Adjei, Rui Kang, Daolin Tang, Neilay Amin, Jaehyun Im, Ronnye Rutledge, Brenda Lin, Andrew A Amoscato, Herbert J Zeh and Michael T Lotze
    Citation: Journal of Translational Medicine 2009 7:17
  5. High-risk neuroblastoma has an overall five-year survival of less than 40%, indicating a need for new treatment strategies such as angiogenesis inhibition. Recent studies have shown that chemotherapeutic drugs...

    Authors: Dieter Fuchs, Rolf Christofferson, Mats Stridsberg, Elin Lindhagen and Faranak Azarbayjani
    Citation: Journal of Translational Medicine 2009 7:16
  6. Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like stem cells having pluripotent differentiation activity and ability to induce neoangiogenesis. In vitro and animal studies suggest ERC a...

    Authors: Zhaohui Zhong, Amit N Patel, Thomas E Ichim, Neil H Riordan, Hao Wang, Wei-Ping Min, Erik J Woods, Michael Reid, Eduardo Mansilla, Gustavo H Marin, Hugo Drago, Michael P Murphy and Boris Minev
    Citation: Journal of Translational Medicine 2009 7:15
  7. High grade gliomas are one of the most difficult cancers to treat and despite surgery, radiotherapy and temozolomide-based chemotherapy, the prognosis of glioma patients is poor. Resistance to temozolomide is ...

    Authors: Annalisa Lena, Mariarosa Rechichi, Alessandra Salvetti, Barbara Bartoli, Donatella Vecchio, Vittoria Scarcelli, Rosina Amoroso, Lucia Benvenuti, Rolando Gagliardi, Vittorio Gremigni and Leonardo Rossi
    Citation: Journal of Translational Medicine 2009 7:13
  8. TGFβ has emerged as an attractive target for the therapeutic intervention of glioblastomas. Aberrant TGFβ overproduction in glioblastoma and other high-grade gliomas has been reported, however, to date, none o...

    Authors: Xie L Xu and Ann M Kapoun
    Citation: Journal of Translational Medicine 2009 7:12
  9. Gene modified dendritic cells (DC) are able to modulate DC functions and induce therapeutic immunity or tolerance in an antigen-specific manner. Among the different DC subsets, plasmacytoid DC (pDC) are well k...

    Authors: Philippe Veron, Sylvie Boutin, Samia Martin, Laurence Chaperot, Joel Plumas, Jean Davoust and Carole Masurier
    Citation: Journal of Translational Medicine 2009 7:10
  10. Novel drugs have to go through mandatory pre-clinical testing before they can be approved for use in clinical trials. In essence, it is a form of bench-to-bedside (N2B) translational medicine, but the wastage ...

    Authors: Lawrence Leung
    Citation: Journal of Translational Medicine 2009 7:9
  11. Members of the TRIP-Br/SERTAD family of mammalian transcriptional coregulators have recently been implicated in E2F-mediated cell cycle progression and tumorigenesis. We, herein, focus on the detailed function...

    Authors: Jit Kong Cheong, Lakshman Gunaratnam, Zhi Jiang Zang, Christopher M Yang, Xiaoming Sun, Susan L Nasr, Khe Guan Sim, Bee Keow Peh, Suhaimi Bin Abdul Rashid, Joseph V Bonventre, Manuel Salto-Tellez and Stephen I Hsu
    Citation: Journal of Translational Medicine 2009 7:8
  12. When comparing myelogenous blasts from bone marrow and peripheral blood, immunophenotyping usually show a strong correlation of expression of surface antigens. However, it remains to be determined, whether thi...

    Authors: Gero Hütter, Anne Letsch, Daniel Nowak, Julia Poland, Pranav Sinha, Eckhard Thiel and Wolf-K Hofmann
    Citation: Journal of Translational Medicine 2009 7:7
  13. The dystrophin gene, located at Xp21, codifies dystrophin, which is part of a protein complex responsible for the membrane stability of muscle cells. Its absence on muscle causes Duchenne Muscular Dystrophy (D...

    Authors: Tatiana Jazedje, Mariane Secco, Natássia M Vieira, Eder Zucconi, Thomaz R Gollop, Mariz Vainzof and Mayana Zatz
    Citation: Journal of Translational Medicine 2009 7:6
  14. Angiostatin, an endogenous angiogenesis inhibitor, is a fragment of plasminogen. Its anti-angiogenic activity was discovered with functional assays in vivo, however, its direct action on endothelial cells is m...

    Authors: Adriana Albini, Claudio Brigati, Agostina Ventura, Girieca Lorusso, Marta Pinter, Monica Morini, Alessandra Mancino, Antonio Sica and Douglas M Noonan
    Citation: Journal of Translational Medicine 2009 7:5
  15. Recently, nanometer sized vesicles (termed exosomes) have been described as a component of urine. Such vesicles may be a useful non-invasive source of markers in renal disease. Their utility as a source of mar...

    Authors: Paul J Mitchell, Joanne Welton, John Staffurth, Jacquelyn Court, Malcolm D Mason, Zsuzsanna Tabi and Aled Clayton
    Citation: Journal of Translational Medicine 2009 7:4
  16. Experimental results from studies with inbred mice and their syngeneic tumors indicated that the inoculation of semi-allogeneic cell hybrids (derived from the fusion between syngeneic tumor cells and an alloge...

    Authors: Jin Yu, Mark S Kindy and Sebastiano Gattoni-Celli
    Citation: Journal of Translational Medicine 2009 7:3
  17. Interleukin-2 (IL-2) induces durable objective responses in a small cohort of patients with metastatic renal cell carcinoma (RCC) but the antigen(s) responsible for tumor rejection are not known. 5T4 is a non-...

    Authors: Howard L Kaufman, Bret Taback, William Sherman, Dae Won Kim, William H Shingler, Dorota Moroziewicz, Gail DeRaffele, Josephine Mitcham, Miles W Carroll, Richard Harrop, Stuart Naylor and Seunghee Kim-Schulze
    Citation: Journal of Translational Medicine 2009 7:2
  18. We previously reported an HLA-A24-restricted cytotoxic T-cell epitope, Survivin-2B80-88, derived from a splice variant of survivin, survivin-2B. In this report, we show a novel HLA-A24-restricted T-cell epitop...

    Authors: Jun-ichi Kobayashi, Toshihiko Torigoe, Yoshihiko Hirohashi, Satomi Idenoue, Akihiro Miyazaki, Akira Yamaguchi, Hiroyoshi Hiratsuka and Noriyuki Sato
    Citation: Journal of Translational Medicine 2009 7:1
  19. The International Society for the Biological Therapy of Cancer (iSBTc) has initiated in collaboration with the United States Food and Drug Administration (FDA) a programmatic look at innovative avenues for the...

    Authors: Lisa H Butterfield, Mary L Disis, Bernard A Fox, Peter P Lee, Samir N Khleif, Magdalena Thurin, Giorgio Trinchieri, Ena Wang, Jon Wigginton, Damien Chaussabel, George Coukos, Madhav Dhodapkar, Leif Håkansson, Sylvia Janetzki, Thomas O Kleen, John M Kirkwood…
    Citation: Journal of Translational Medicine 2008 6:81
  20. Effective transvascular delivery of nanoparticle-based chemotherapeutics across the blood-brain tumor barrier of malignant gliomas remains a challenge. This is due to our limited understanding of nanoparticle ...

    Authors: Hemant Sarin, Ariel S Kanevsky, Haitao Wu, Kyle R Brimacombe, Steve H Fung, Alioscka A Sousa, Sungyoung Auh, Colin M Wilson, Kamal Sharma, Maria A Aronova, Richard D Leapman, Gary L Griffiths and Matthew D Hall
    Citation: Journal of Translational Medicine 2008 6:80
  21. A large percentage of patients with recurrent ovarian cancer develop resistance to the taxane class of chemotherapeutics. While mechanisms of resistance are being discovered, novel treatment options and a bett...

    Authors: Christopher D Scharer, Noelani Laycock, Adeboye O Osunkoya, Sanjay Logani, John F McDonald, Benedict B Benigno and Carlos S Moreno
    Citation: Journal of Translational Medicine 2008 6:79
  22. Animal models greatly facilitate understanding of cancer and importantly, serve pre-clinically for evaluating potential anti-cancer therapies. We developed an invasive orthotopic human glioblastoma multiforme ...

    Authors: Qian Xie, Ryan Thompson, Kim Hardy, Lisa DeCamp, Bree Berghuis, Robert Sigler, Beatrice Knudsen, Sandra Cottingham, Ping Zhao, Karl Dykema, Brian Cao, James Resau, Rick Hay and George F Vande Woude
    Citation: Journal of Translational Medicine 2008 6:77
  23. Pharmacodynamic assays are important in clinical trial design to investigate the relationship between drug concentration (pharmacokinetics) and drug "effect' or biological activity. Increasingly flow cytometry...

    Authors: Timothy Wyant, Alan Lackey and Marie Green
    Citation: Journal of Translational Medicine 2008 6:76
  24. Multiple physiologic impairments are responsible for chronic wounds. A cell line grown which retains its phenotype from patient wounds would provide means of testing new therapies. Clinical information on pati...

    Authors: Harold Brem, Michael S Golinko, Olivera Stojadinovic, Arber Kodra, Robert F Diegelmann, Sasa Vukelic, Hyacinth Entero, Donald L Coppock and Marjana Tomic-Canic
    Citation: Journal of Translational Medicine 2008 6:75
  25. The molecular etiology of hearing impairment in Chinese has not been thoroughly investigated. Study of GJB2 gene revealed that 30.4% of the patients with hearing loss in Inner Mongolia carried GJB2 mutations. The...

    Authors: Pu Dai, Yongyi Yuan, Deliang Huang, Xiuhui Zhu, Fei Yu, Dongyang Kang, Huijun Yuan, Bailin Wu, Dongyi Han and Lee-Jun C Wong
    Citation: Journal of Translational Medicine 2008 6:74
  26. The development of postoperative granulation tissue is one of the main postoperative risks after lumbar spine surgery. This granulation tissue may lead to persistent or new clinical symptoms or complicate a fo...

    Authors: Reinhard Meier, Sophie Boddington, Christian Krug, Frank L Acosta, Daniel Thullier, Tobias D Henning, Elizabeth J Sutton, Sidhartha Tavri, Jeffrey C Lotz and Heike E Daldrup-Link
    Citation: Journal of Translational Medicine 2008 6:73
  27. Inside the spectrum of non-alcoholic fatty liver disease, simple fatty liver is generally thought of as being "non progressive", differently from non-alcoholic steatohepatitis, which increases in severity due ...

    Authors: Giovanni Tarantino, Paolo Conca, Antonio Riccio, Marianna Tarantino, Matteo N Di Minno, Domenico Chianese, Fabrizio Pasanisi, Franco Contaldo, Francesco Scopacasa and Domenico Capone
    Citation: Journal of Translational Medicine 2008 6:72
  28. Different Insulin-like Growth Factor Binding Proteins (IGFBPs) have been investigated as potential biomarkers in several types of tumors. In this study, we examined both IGFBP-3 and -4 levels in tissues and se...

    Authors: Jessie Z Yu, Melanie A Warycha, Paul J Christos, Farbod Darvishian, Herman Yee, Hideko Kaminio, Russell S Berman, Richard L Shapiro, Michael T Buckley, Leonard F Liebes, Anna C Pavlick, David Polsky, Peter C Brooks and Iman Osman
    Citation: Journal of Translational Medicine 2008 6:70
  29. We examined gene expression profiles of tumor cells from 29 untreated patients with lung cancer (10 adenocarcinomas (AC), 10 squamous cell carcinomas (SCC), and 9 small cell lung cancer (SCLC)) in comparison t...

    Authors: Astrid Rohrbeck, Judith Neukirchen, Michael Rosskopf, Guillermo G Pardillos, Helene Geddert, Andreas Schwalen, Helmut E Gabbert, Arndt von Haeseler, Gerald Pitschke, Matthias Schott, Ralf Kronenwett, Rainer Haas and Ulrich-Peter Rohr
    Citation: Journal of Translational Medicine 2008 6:69
  30. Essential tremor (ET) is the most common movement disorder and its pathophysiology is unknown. We hypothesize that increased membrane excitability in motor circuits has a key role in the pathogenesis of ET. Sp...

    Authors: Aasef G Shaikh, Kenichiro Miura, Lance M Optican, Stefano Ramat, Robert M Tripp and David S Zee
    Citation: Journal of Translational Medicine 2008 6:68
  31. The implantation of neural stem cells (NSCs) in artificial scaffolds for peripheral nerve injuries draws much attention. NSCs were ex-vivo expanded in hyaluronic acid (HA)-collagen composite with neurotrophin-3, ...

    Authors: Han Zhang, Yue Teng Wei, Kam Sze Tsang, Chong Ran Sun, Jin Li, Hua Huang, Fu Zhai Cui and Yi Hua An
    Citation: Journal of Translational Medicine 2008 6:67
  32. This study determined the kinetics of gene expression during the first 10 weeks of therapy with Pegylated-interferon-alfa2b (PegIntron™) and ribavirin (administered by weight) in HCV patients and compared it w...

    Authors: Milton W Taylor, Takuma Tsukahara, Jeanette N McClintick, Howard J Edenberg and Paul Kwo
    Citation: Journal of Translational Medicine 2008 6:66
  33. Docetaxel and gemcitabine combinations have proven active for the treatment of non-small cell lung cancer (NSCLC). The aim of the present study was to evaluate and compare two treatment schedules, one based on...

    Authors: Alessandro Passardi, Lorenzo Cecconetto, Monia Dall'Agata, Claudio Dazzi, Enzo Pasquini, Giovanni Oliverio, Federica Zumaglini, Wainer Zoli, Oriana Nanni, Carlo Milandri, Giovanni Luca Frassineti and Dino Amadori
    Citation: Journal of Translational Medicine 2008 6:65
  34. The need for fast, efficient, and less costly means to screen genetic variants associated with disease predisposition led us to develop an oligo-nucleotide array-based process for gene-specific single nucleoti...

    Authors: Alessandro Monaco, Filippo Menolascina, Yingdong Zhao, Stefania Tommasi, Marianna Sabatino, Ross Fasano, Angelo Paradiso, Francesco M Marincola and Ena Wang
    Citation: Journal of Translational Medicine 2008 6:64
  35. HLA-A2 tetramer flow cytometry, IFNγ real time RT-PCR and IFNγ ELISPOT assays are commonly used as surrogate immunological endpoints for cancer immunotherapy. While these are often used as research assays to a...

    Authors: Yuanxin Xu, Valerie Theobald, Crystal Sung, Kathleen DePalma, Laura Atwater, Keirsten Seiger, Michael A Perricone and Susan M Richards
    Citation: Journal of Translational Medicine 2008 6:61
  36. The adoptive transfer of autologous tumor reactive lymphocytes can mediate significant tumor regression in some patients with refractory metastatic cancer. However, a significant obstacle for this promising th...

    Authors: Udai S Kammula and Oscar K Serrano
    Citation: Journal of Translational Medicine 2008 6:60
  37. LXRs (Liver X Receptor α and β) are nuclear receptors that act as ligand-activated transcription factors. LXR activation causes upregulation of genes involved in reverse cholesterol transport (RCT), including ...

    Authors: Elizabeth A DiBlasio-Smith, Maya Arai, Elaine M Quinet, Mark J Evans, Tad Kornaga, Michael D Basso, Liang Chen, Irene Feingold, Anita R Halpern, Qiang-Yuan Liu, Ponnal Nambi, Dawn Savio, Shuguang Wang, William M Mounts, Jennifer A Isler, Anna M Slager…
    Citation: Journal of Translational Medicine 2008 6:59
  38. Monitoring of cellular immune responses is indispensable in a number of clinical research areas, including microbiology, virology, oncology and autoimmunity. Purification and culture of peripheral blood mononu...

    Authors: Elke Schultz-Thater, Daniel M Frey, Daniela Margelli, Nermin Raafat, Chantal Feder-Mengus, Giulio C Spagnoli and Paul Zajac
    Citation: Journal of Translational Medicine 2008 6:58
  39. The recruitment of vascular stromal and endothelial cells is an early event occurring during cancer cell growth at premetastatic niches, but how the microenvironment created by the initial three-dimensional (3...

    Authors: María Valcárcel, Beatriz Arteta, Arrate Jaureguibeitia, Aritz Lopategi, Iñigo Martínez, Lorea Mendoza, Francisco J Muruzabal, Clarisa Salado and Fernando Vidal-Vanaclocha
    Citation: Journal of Translational Medicine 2008 6:57
  40. Recent studies demonstrate that recombinant adeno-associated virus (rAAV)-based antigen loading of dendritic cells (DCs) generates in vitro, significant and rapid cytotoxic T-lymphocyte (CTL) responses against vi...

    Authors: Yuefei Yu, Petra Pilgrim, Juqiang Yan, Wei Zhou, Marjorie Jenkins, Nicoletta Gagliano, Klaus Bumm, Martin Cannon, Aldo Milzani, Isabella Dalle-Donne, W Martin Kast, Everardo Cobos and Maurizio Chiriva-Internati
    Citation: Journal of Translational Medicine 2008 6:56
  41. High resistance to drug is taken as a characteristic of human tumors, which is usually mediated by multidrug resistance-associated genes. ABCC2, an ATP-binding cassette multidrug resistance transporter, is fou...

    Authors: Si Ming Xie, Wei Yi Fang, Zhen Liu, Shuang Xi Wang, Xin Li, Teng Fei Liu, Wei Bing Xie and Kai Tai Yao
    Citation: Journal of Translational Medicine 2008 6:55
  42. We previously demonstrated that vascular endothelial growth factor receptor type 2 (VEGF-R2)-positive cells induced from mouse embryonic stem (ES) cells can differentiate into both endothelial cells (ECs) and ...

    Authors: Naofumi Oyamada, Hiroshi Itoh, Masakatsu Sone, Kenichi Yamahara, Kazutoshi Miyashita, Kwijun Park, Daisuke Taura, Megumi Inuzuka, Takuhiro Sonoyama, Hirokazu Tsujimoto, Yasutomo Fukunaga, Naohisa Tamura and Kazuwa Nakao
    Citation: Journal of Translational Medicine 2008 6:54
  43. Metastatic melanoma is a highly chemotherapy resistant tumour. The use of newer targeted therapies alone and in combination with chemotherapy may offer new hope of improving response to treatment. Dasatinib, a...

    Authors: Alex J Eustace, John Crown, Martin Clynes and Norma O'Donovan
    Citation: Journal of Translational Medicine 2008 6:53
  44. Biomarkers are pivotal for cancer detection, diagnosis, prognosis and therapeutic monitoring. However, currently available cancer biomarkers have the disadvantage of lacking specificity and/or sensitivity. Dev...

    Authors: Hua Xue, Bingjian Lu and Maode Lai
    Citation: Journal of Translational Medicine 2008 6:52

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