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  1. Clinical observations suggested that a non negligible proportion of patients, ranging from 40% to 70%, does not seem to benefit from the use of anti-EGFR targeted antibodies even in the absence of a mutation o...

    Authors: Mario Scartozzi, Riccardo Giampieri, Elena Maccaroni, Alessandra Mandolesi, Simona Biagetti, Simona Alfonsi, Lucio Giustini, Cristian Loretelli, Luca Faloppi, Alessandro Bittoni, Maristella Bianconi, Michela Del Prete, Italo Bearzi and Stefano Cascinu
    Citation: Journal of Translational Medicine 2012 10:71
  2. The development of cancer has historically been attributed to genomic alterations of normal host cells. Accordingly, the aim of most traditional cancer therapies has been to destroy the transformed cells thems...

    Authors: Leisha A Emens, Samuel C Silverstein, Samir Khleif, Francesco M Marincola and Jérôme Galon
    Citation: Journal of Translational Medicine 2012 10:70
  3. To simplify clinical scale lymphocyte expansions, we investigated the use of the WAVE®, a closed system bioreactor that utilizes active perfusion to generate high cell numbers in minimal volumes.

    Authors: Robert PT Somerville, Laura Devillier, Maria R Parkhurst, Steven A Rosenberg and Mark E Dudley
    Citation: Journal of Translational Medicine 2012 10:69
  4. Previously assumed to be a select ligand for chemokine receptor CXCR4, chemokine CXCL12 is now known to activate both CXCR4 and CXCR7. However, very little is known about the co-expression of these receptors i...

    Authors: Eileen L Heinrich, Wendy Lee, Jianming Lu, Andrew M Lowy and Joseph Kim
    Citation: Journal of Translational Medicine 2012 10:68
  5. Hypoxia and hypertrophy are the most frequent pathophysiological consequence of congenital heart disease (CHD) which can induce the alteration of Ca2+-regulatory proteins and inhibit cardiac contractility. Few st...

    Authors: Yihe Wu, Wei Feng, Hao Zhang, Shoujun Li, De Wang, Xiangbin Pan and Shengshou Hu
    Citation: Journal of Translational Medicine 2012 10:67
  6. Treatment of acute myocardial infarction with stem cell transplantation has achieved beneficial effects in many clinical trials. The bone marrow microenvironment of ST-elevation myocardial infarction (STEMI) p...

    Authors: Johanna A Miettinen, Riikka J Salonen, Kari Ylitalo, Matti Niemelä, Kari Kervinen, Marjaana Säily, Pirjo Koistinen, Eeva-Riitta Savolainen, Timo H Mäkikallio, Heikki V Huikuri and Petri Lehenkari
    Citation: Journal of Translational Medicine 2012 10:66
  7. Previous studies suggest that oxidative stress plays an important role in the development of breast cancer. There is a significant inverse relationship between HDL and the risk and mortality of breast cancer. ...

    Authors: Bing Pan, Hui Ren, Xiaofeng Lv, Yangyu Zhao, Baoqi Yu, Yubin He, Yijing Ma, Chenguang Niu, Jinge Kong, Fangzhu Yu, Wen-bing Sun, Youyi Zhang, Belinda Willard and Lemin Zheng
    Citation: Journal of Translational Medicine 2012 10:65
  8. This study was designed to determine the pattern and correlation between expression of the HIF-1α transcriptional targets TGM2 and BNIP3 in laryngeal cancer, and investigate the association of BNIP3 and TGM2 w...

    Authors: Ting Jin, Huan-Xin Lin, Hui Lin, Li-Bing Guo, Nan Ge, Xiu-Yu Cai, Rui Sun, Wen-Kuan Chen, Qiu-Li Li and Wei-Han Hu
    Citation: Journal of Translational Medicine 2012 10:64
  9. Nutrition has been widely recognized to influence the risk of kidney stone formation. Therefore the aim of our study was to assess: a) whether usual diet of women with idiopathic calcium nephrolithiasis (ICN) ...

    Authors: Tiziana Meschi, Antonio Nouvenne, Andrea Ticinesi, Beatrice Prati, Angela Guerra, Franca Allegri, Federica Pigna, Laura Soldati, Giuseppe Vezzoli, Giovanni Gambaro, Fulvio Lauretani, Marcello Maggio and Loris Borghi
    Citation: Journal of Translational Medicine 2012 10:63
  10. Systems-level approaches are increasingly common in both murine and human translational studies. These approaches employ multiple high information content assays. As a result, there is a need for tools to inte...

    Authors: Janet C Siebert, Wes Munsil, Yael Rosenberg-Hasson, Mark M Davis and Holden T Maecker
    Citation: Journal of Translational Medicine 2012 10:62
  11. FDA has recently asserted that many autologous cell therapies once considered the practice of medicine are in fact drugs. These changes began with the creation of new sections of 21 CFR 1271 and a subsequent o...

    Authors: Michael Freeman and Mitchell Fuerst
    Citation: Journal of Translational Medicine 2012 10:60
  12. RhoA-Rho kinase complex contributes to keep the cavernosus smooth muscle contracted and its inhibition is considered a potential strategy for the therapy of erectile dysfunction (ED).

    Authors: Fabio Guagnini, Mara Ferazzini, Marco Grasso, Salvatore Blanco and Tiziano Croci
    Citation: Journal of Translational Medicine 2012 10:59
  13. We conducted a pilot study of the infusion of intravenous autologous cord blood (CB) in children with cerebral palsy (CP) to assess the safety and feasibility of the procedure as well as its potential efficacy...

    Authors: Young-Ho Lee, Kyung Vin Choi, Jin Hwa Moon, Hyun-Joo Jun, Hye-Ryeong Kang, Se-In Oh, Hyung Sun Kim, Jang Soo Um, Mi Jung Kim, Yun Young Choi, Young-Jun Lee, Hee-Jin Kim, Jong-Hwa Lee, Su Min Son, Soo-Jin Choi, Wonil Oh…
    Citation: Journal of Translational Medicine 2012 10:58
  14. Nasopharyngeal carcinoma (NPC) is a multi-factorial malignancy closely associated with environmental factors, genetic factors and Epstein-Barr virus infection. Human leukocyte antigen (HLA) complex, specially ...

    Authors: Manli Zhao, Hongbing Cai, Xin Li, Hang Zheng, Xuexi Yang, Weiyi Fang, Longcheng Zhang, Ganguan Wei, Ming Li, Kaitai Yao and Xin Li
    Citation: Journal of Translational Medicine 2012 10:57
  15. Nearly one-third of the United States adult population suffers from hypertension. Hydrochlorothiazide (HCTZ), one of the most commonly used medications to treat hypertension, has variable efficacy. The renal e...

    Authors: Julio D Duarte, Issam Zineh, Ben Burkley, Yan Gong, Taimour Y Langaee, Stephen T Turner, Arlene B Chapman, Eric Boerwinkle, John G Gums, Rhonda M Cooper-DeHoff, Amber L Beitelshees, Kent R Bailey, Roger B Fillingim, Bruce C Kone and Julie A Johnson
    Citation: Journal of Translational Medicine 2012 10:56
  16. There is no standard serum biomarker used for diagnosis or early detection of recurrence for renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and highly stable in blood serum, and have been...

    Authors: Martina Redova, Alexandr Poprach, Jana Nekvindova, Robert Iliev, Lenka Radova, Radek Lakomy, Marek Svoboda, Rostislav Vyzula and Ondrej Slaby
    Citation: Journal of Translational Medicine 2012 10:55
  17. We have previously reported the induction of many interferon stimulated genes (ISGs) in PBMC collected from patients infected with HCV at various times after initiation of interferon-ribavirin treatment using ...

    Authors: Rahul Gupta, Sun Kim and Milton W Taylor
    Citation: Journal of Translational Medicine 2012 10:54
  18. The RAS/MAP kinase pathway has attracted attention because activating mutations of the BRAF serine/threonine kinase was described in over 50% of melanomas. Very recently, selective and potent BRAF inhibitors h...

    Authors: Gabriele Madonna, Claudio Dansky Ullman, Giusy Gentilcore, Giuseppe Palmieri and Paolo Antonio Ascierto
    Citation: Journal of Translational Medicine 2012 10:53
  19. The study was performed to investigate the expression of chemokine receptors (CR) on circulating tumor cells (CTC), which may be of importance for organ-specific metastases and cancer treatment since CR are po...

    Authors: Alberto Fusi, Zhian Liu, Verena Kümmerlen, Anika Nonnemacher, Judith Jeske and Ulrich Keilholz
    Citation: Journal of Translational Medicine 2012 10:52
  20. This study evaluated the effectiveness of treating pseudarthrosis in rats by using bone marrow cell suspensions or cultures of bone marrow mesenchymal stromal cells

    Authors: Manoel Luiz Ferreira, Paulo Cesar Silva, Lucas Henrique Alvarez Silva, Danielle Cabral Bonfim, Lucas Cristo Conilho Macedo Müller, Christiano Costa Espósito and Alberto Schanaider
    Citation: Journal of Translational Medicine 2012 10:51
  21. Hepatic steatosis (HS) has been associated with obesity and metabolic syndrome (MS), conditions carrying a high risk of coronary artery disease. We aimed to determine whether HS was an independent factor of at...

    Authors: Giovanni Tarantino, Carmine Finelli, Annamaria Colao, Domenico Capone, Marianna Tarantino, Ernesto Grimaldi, Donato Chianese, Saverio Gioia, Fabrizio Pasanisi, Franco Contaldo, Francesco Scopacasa and Silvia Savastano
    Citation: Journal of Translational Medicine 2012 10:50
  22. Human adipose-derived mesenchymal stem cells (ADMSCs) may be ideal source of cells for intervertebral disc (IVD) regeneration, but the harsh chemical microenvironment of IVD may significantly influence the bio...

    Authors: Chengzhen Liang, Hao Li, Yiqing Tao, Xiaopeng Zhou, Fangcai Li, Gang Chen and Qixin Chen
    Citation: Journal of Translational Medicine 2012 10:49
  23. A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly...

    Authors: David F Stroncek, Carolina Berger, Martin A Cheever, Richard W Childs, Mark E Dudley, Peter Flynn, Luca Gattinoni, James R Heath, Michael Kalos, Francesco M Marincola, Jeffrey S Miller, Gustavo Mostoslavsky, Daniel J Powell Jr, Mahendra Rao, Nicholas P Restifo, Steven A Rosenberg…
    Citation: Journal of Translational Medicine 2012 10:48
  24. To determine whether office, home, ambulatory daytime and nighttime blood pressure (BP) responses to antihypertensive drug therapy measure the same signal and which method provides greatest power to identify g...

    Authors: Stephen T Turner, Gary L Schwartz, Arlene B Chapman, Amber L Beitelshees, John G Gums, Rhonda M Cooper-DeHoff, Eric Boerwinkle, Julie A Johnson and Kent R Bailey
    Citation: Journal of Translational Medicine 2012 10:47
  25. The testicular yolk sac tumor (TYST) is the most common neoplasm originated from germ cells differentiated abnormally, a major part of pediatric malignant testicular tumors. The present study aimed at developi...

    Authors: Junfeng Zhao, Congde Chen, Haochuan Zhang, Jinhui Shen, Hua Zhang, Xiaokun Lin, Le Qin, Xiaozhou Bao, Jie Lin, Wenqiang Lu, Xiangdong Wang and Xiaoming Chen
    Citation: Journal of Translational Medicine 2012 10:46
  26. Concomitant with the development of in vitro diagnostic multivariate index assays (IVDMIAs) to improve the diagnostic efficiency of ovarian cancer detection is the need to identify appropriate biostatistical appr...

    Authors: Dominic J Autelitano, Linda Raineri, Kate Knight, Kelly Bannister and Gregory E Rice
    Citation: Journal of Translational Medicine 2012 10:45
  27. Over-diagnosis and treatment of prostate cancer has been a major problem in prostate cancer care and management. Currently the most relevant prognostic factor to predict a patient's risk of death due to prosta...

    Authors: Qun Huo, Sally A Litherland, Shannon Sullivan, Hillari Hallquist, David A Decker and Inoel Rivera-Ramirez
    Citation: Journal of Translational Medicine 2012 10:44
  28. Leber hereditary optic neuropathy (LHON) is a mitochondrial disorder with gender biased and incomplete penetrance. The majority of LHON patients are caused by one of the three primary mutations (m.3460G > A, m...

    Authors: A-Mei Zhang, Xiaoyun Jia, Xiangming Guo, Qingjiong Zhang and Yong-Gang Yao
    Citation: Journal of Translational Medicine 2012 10:43
  29. MicroRNAs (miRNAs) have been recently detected in the circulation of cancer patients, where they are associated with clinical parameters. Discovery profiling of circulating small RNAs has not been reported in ...

    Authors: Xiwei Wu, George Somlo, Yang Yu, Melanie R Palomares, Arthur Xuejun Li, Weiying Zhou, Amy Chow, Yun Yen, John J Rossi, Harry Gao, Jinhui Wang, Yate-Ching Yuan, Paul Frankel, Sierra Li, Kimlin Tam Ashing-Giwa, Guihua Sun…
    Citation: Journal of Translational Medicine 2012 10:42
  30. Hepatitis C virus (HCV) causes liver fibrosis that may lead to liver cirrhosis or hepatocellular carcinoma (HCC), and may partially depend on infecting viral genotype. HCV genotype 3a is being more common in A...

    Authors: Waqar Ahmad, Bushra Ijaz and Sajida Hassan
    Citation: Journal of Translational Medicine 2012 10:41
  31. Prostaglandins (PG) are widely employed to induce cervical remodelling (CR) in pregnancy. However, the underlying molecular mechanisms are not fully elucidated. Tight junctions (TJ) and gap junctions (GJ) regu...

    Authors: Vidita V Ghulé, Colin Gray, Andrea Galimberti and Dilly OC Anumba
    Citation: Journal of Translational Medicine 2012 10:40
  32. Translational medicine describes the transfer of basic in vitro and in vivo data into human applications. In the light of low rates of market approvals for new medical entities, better strategies to predict the r...

    Authors: Alexandra Wendler and Martin Wehling
    Citation: Journal of Translational Medicine 2012 10:39
  33. Advanced endometrial cancer often shows resistance to clinical chemotherapy although potencies of anticancer drugs in vitro are promising. The disparity suggests that in vi vo microenvironments are not recapitula...

    Authors: Kenny Chitcholtan, Peter H Sykes and John J Evans
    Citation: Journal of Translational Medicine 2012 10:38
  34. Methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter is a favorable prognostic factor in glioblastoma patients. However, reported methylation frequencies vary significantly partly due to...

    Authors: Annette Bentsen Håvik, Petter Brandal, Hilde Honne, Hanne-Sofie Spenning Dahlback, David Scheie, Merete Hektoen, Torstein Ragnar Meling, Eirik Helseth, Sverre Heim, Ragnhild A Lothe and Guro Elisabeth Lind
    Citation: Journal of Translational Medicine 2012 10:36
  35. Diabetic patients are at increased risk for bacterial infections; these studies provide new insight into the role of the host defense complement system in controlling bacterial pathogens in hyperglycemic envir...

    Authors: Pamela S Hair, Charlene G Echague, Reuben D Rohn, Neel K Krishna, Julius O Nyalwidhe and Kenji M Cunnion
    Citation: Journal of Translational Medicine 2012 10:35
  36. Medication non adherence is a global epidemic perplexing phenomenon that is eminent, but not insurmountable. Our first objective was to explore whether providing pharmacist's counseling to cardiac patients pri...

    Authors: Bishara Bisharat, Lubna Hafi, Orna Baron-Epel, Zaher Armaly and Abdalla Bowirrat
    Citation: Journal of Translational Medicine 2012 10:34
  37. The immune system strongly influences outcome in patients with ovarian cancer. In particular, the absolute lymphocyte count in peripheral blood (ALC) and the presence of tumor-infiltrating lymphocytes (TIL) ha...

    Authors: Katy Milne, Cheryl Alexander, John R Webb, Winnie Sun, Kristy Dillon, Steve E Kalloger, C Blake Gilks, Blaise Clarke, Martin Köbel and Brad H Nelson
    Citation: Journal of Translational Medicine 2012 10:33
  38. Historically, extended haplotypes have been defined using only a few data points, such as alleles for several HLA genes in the MHC. High-density SNP data, and the increasing affordability of whole genome SNP t...

    Authors: Erin E Baschal, Jean M Jasinski, Theresa A Boyle, Pamela R Fain, George S Eisenbarth and Janet C Siebert
    Citation: Journal of Translational Medicine 2012 10:32
  39. Programmed cell death 6 (PDCD6) beside its known proapoptotic functions may be a player in survival pathways in cancer. The purpose of this study is to further explore the roles of PDCD6 in epithelial ovarian ...

    Authors: Dan Su, Haiyan Xu, Jianguo Feng, Yun Gao, Linhui Gu, Lisha Ying, Dionyssios Katsaros, Herbert Yu, Shenhua Xu and Ming Qi
    Citation: Journal of Translational Medicine 2012 10:31
  40. To date very few systems have been described for preclinical investigations of human cellular therapeutics in vivo. However, the ability to carry out comparisons of new cellular vaccines in vivo would be of subst...

    Authors: Stefani Spranger, Bernhard Frankenberger and Dolores J Schendel
    Citation: Journal of Translational Medicine 2012 10:30
  41. There has been significant progress in the last two decades on the design of chimeric antigen receptors (CAR) for adoptive immunotherapy targeting tumor-associated antigens. Structurally CARs consist of a sing...

    Authors: Zhili Zheng, Nachimuthu Chinnasamy and Richard A Morgan
    Citation: Journal of Translational Medicine 2012 10:29
  42. Patients with HER2-overexpressing metastatic breast cancer, despite initially benefiting from the monoclonal antibody trastuzumab and the EGFR/HER2 tyrosine kinase inhibitor lapatinib, will eventually have pro...

    Authors: Erika Hamilton, Kimberly Blackwell, Amy C Hobeika, Timothy M Clay, Gloria Broadwater, Xiu-Rong Ren, Wei Chen, Henry Castro, Frederic Lehmann, Neil Spector, Junping Wei, Takuya Osada and H Kim Lyerly
    Citation: Journal of Translational Medicine 2012 10:28

    The Erratum to this article has been published in Journal of Translational Medicine 2013 11:82

  43. The aim of the present study was to analyse the expression of Secreted protein acidic and rich in cysteine (SPARC) in nasopharyngeal carcinoma (NPC) specimens, and to evaluate its correlation with clinicopatho...

    Authors: Hai-Yun Wang, Yang-Yang Li, Qiong Shao, Jing-Hui Hou, Fang Wang, Man-Bo Cai, Yi-Xin Zeng and Jian-Yong Shao
    Citation: Journal of Translational Medicine 2012 10:27
  44. Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex natur...

    Authors: Qiong-Lin Liang, Xiao-Ping Liang, Yi-Ming Wang, Yuan-Yuan Xie, Rong-Li Zhang, Xi Chen, Rong Gao, Yi-Jun Cheng, Jun Wu, Qing-Bo Xu, Qing-Zhong Xiao, Xue Li, Shu-Feng Lv, Xue-Mei Fan, Hong-Yang Zhang, Qing-Li Zhang…
    Citation: Journal of Translational Medicine 2012 10:26
  45. Recent studies of CH-C patients have demonstrated a strong association between IL28B CC genotype and sustained virologic response (SVR) after PEG-IFN/RBV treatment. We aimed to assess whether IL28B alleles rs1...

    Authors: Zobair M Younossi, Aybike Birerdinc, Mike Estep, Maria Stepanova, Arian Afendy and Ancha Baranova
    Citation: Journal of Translational Medicine 2012 10:25
  46. High-sensitivity C-reactive protein (hs-CRP) assay is of great clinical importance in predicting risks associated with coronary heart disease. Existing hs-CRP assays either require complex operation or have lo...

    Authors: Yang Luo, Bo Zhang, Ming Chen, Tianlun Jiang, Daiyang Zhou, Junfu Huang and Weiling Fu
    Citation: Journal of Translational Medicine 2012 10:24
  47. Bone marrow stromal cells (BMSCs) are being used to treat a variety of conditions. For many applications a supply of cryopreserved products that can be used for acute therapy is needed. The establishment of a ...

    Authors: Marianna Sabatino, Jiaqiang Ren, Virginia David-Ocampo, Lee England, Michael McGann, Minh Tran, Sergei A Kuznetsov, Hanh Khuu, Arun Balakumaran, Harvey G Klein, Pamela G Robey and David F Stroncek
    Citation: Journal of Translational Medicine 2012 10:23
  48. A mobile health unit may be useful to follow up adult and pediatric patients on antiretroviral treatment and living in remote areas devoid of laboratory facilities. The study evaluated the use of the simplifie...

    Authors: François-Xavier Mbopi-Kéou, Bertrand Sagnia, Jeanne Ngogang, Fru F Angwafo III, Vittorio Colizzi, Luc Montagnier and Laurent Bélec
    Citation: Journal of Translational Medicine 2012 10:22

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