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  1. The role of body composition (lean mass and fat mass) on urine chemistries and bone quality is still debated. Our aim was therefore to determine the effect of lean mass and fat mass on urine composition and bo...

    Authors: Antonio Nouvenne, Andrea Ticinesi, Angela Guerra, Giuseppina Folesani, Franca Allegri, Silvana Pinelli, Paolo Baroni, Mario Pedrazzoni, Giuseppe Lippi, Annalisa Terranegra, Elena Dogliotti, Laura Soldati, Loris Borghi and Tiziana Meschi
    Citation: Journal of Translational Medicine 2013 11:248
  2. HLA abnormalities on tumour cells for immune escape have been widely described. In addition, cellular components of the tumour microenvironment, in particular myeloid derived suppressor cells (MDSC) and altern...

    Authors: Maddalena Marchesi, Emilia Andersson, Lisa Villabona, Barbara Seliger, Andreas Lundqvist, Rolf Kiessling and Giuseppe V Masucci
    Citation: Journal of Translational Medicine 2013 11:247
  3. Cholesteryl pullulan (CHP) is a novel antigen delivery system for cancer vaccines. This study evaluated the safety, immune responses and clinical outcomes of patients who received the CHP-NY-ESO-1 complex vacc...

    Authors: Shinichi Kageyama, Hisashi Wada, Kei Muro, Yasumasa Niwa, Shugo Ueda, Hiroshi Miyata, Shuji Takiguchi, Sahoko H Sugino, Yoshihiro Miyahara, Hiroaki Ikeda, Naoko Imai, Eiichi Sato, Tomomi Yamada, Masaharu Osako, Mami Ohnishi, Naozumi Harada…
    Citation: Journal of Translational Medicine 2013 11:246
  4. Protein Tyrosine Phosphatase Receptor-type O (PTPRO) has recently been in the spotlight as a tumor suppressor, whose encoding gene is frequently methylated in cancers. We examined the methylation status of the...

    Authors: Yi-Teng Huang, Fei-Fei Li, Chen Ke, Zhou Li, Zong-Tai Li, Xiao-Fang Zou, Xiao-Xuan Zheng, Yu-Ping Chen and Hao Zhang
    Citation: Journal of Translational Medicine 2013 11:245
  5. As organ shortage is increasing, the acceptance of marginal donors increases, which might result in poor organ function and patient survival. Mostly, organ damage is caused during brain death (BD), cold ischem...

    Authors: Philipp Stiegler, Michael Sereinigg, Andreas Puntschart, Andrea Bradatsch, Thomas Seifert-Held, Iris Wiederstein-Grasser, Bettina Leber, Elke Stadelmeyer, Nadia Dandachi, Siglinde Zelzer, Florian Iberer and Vanessa Stadlbauer
    Citation: Journal of Translational Medicine 2013 11:244
  6. Chronic Fatigue Syndrome (CFS) is a severe, systemic illness characterized by persistent, debilitating and medically unexplained fatigue. The etiology and pathophysiology of CFS remains obscure, and diagnosis ...

    Authors: Federica Ciregia, Laura Giusti, Ylenia Da Valle, Elena Donadio, Arianna Consensi, Camillo Giacomelli, Francesca Sernissi, Pietro Scarpellini, Fabrizio Maggi, Antonio Lucacchini and Laura Bazzichi
    Citation: Journal of Translational Medicine 2013 11:243
  7. Dendritic cells (DCs) are important mediators of anti-tumor immune responses. We hypothesized that an in-depth analysis of dendritic cells and their spatial relationships to each other as well as to other immu...

    Authors: Andrew Y Chang, Nupur Bhattacharya, Jian Mu, A Francesca Setiadi, Valeria Carcamo-Cavazos, Gerald H Lee, Diana L Simons, Sina Yadegarynia, Kaveh Hemati, Adam Kapelner, Zheng Ming, David N Krag, Erich J Schwartz, Danny Z Chen and Peter P Lee
    Citation: Journal of Translational Medicine 2013 11:242
  8. Activation of the PI3K/AKT pathway is a common phenomenon in cancer due to multiple mechanisms, including mutation of PI3KCA, loss or mutation of PTEN, or over-expression of receptor tyrosine kinases. We recen...

    Authors: Jing Li, Barry R Davies, Sufang Han, Minhua Zhou, Yu Bai, Jingchuan Zhang, Yan Xu, Lily Tang, Huiying Wang, Yuan Jie Liu, Xiaolu Yin, Qunsheng Ji and De-Hua Yu
    Citation: Journal of Translational Medicine 2013 11:241
  9. In this study, we developed a pharmacokinetic (PK)- pharmacodynamic (PD) model of a new sustained release formulation of interferon-α-2a (SR-IFN-α) using the blood concentration of IFN-α and neopterin in order...

    Authors: Sangil Jeon, Jae-Hyeon Juhn, Seunghoon Han, Jongtae Lee, Taegon Hong, Jeongki Paek and Dong-Seok Yim
    Citation: Journal of Translational Medicine 2013 11:240
  10. The incidence and mortality of hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) is higher in African Americans (AA) than other racial/ethnic groups in the U.S., but the reasons for this disparity...

    Authors: Simon T Dillon, Manoj K Bhasin, Xiaoxing Feng, David W Koh and Sayed S Daoud
    Citation: Journal of Translational Medicine 2013 11:239
  11. The chemokine CXCL12 and its receptor CXCR4 play a major role in tumor invasion, proliferation and metastasis in different malignant diseases, including esophageal carcinoma, amongst others. CXCR7 was recently...

    Authors: Michael Tachezy, Hilke Zander, Florian Gebauer, Katharina von Loga, Klaus Pantel, Jakob R Izbicki and Maximilian Bockhorn
    Citation: Journal of Translational Medicine 2013 11:238
  12. Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma and the clinical management of patients with unresectable, metastatic disease is still challenging. ASPS expresses an array of potentially therap...

    Authors: Chiara Castelli, Marcella Tazzari, Tiziana Negri, Barbara Vergani, Licia Rivoltini, Silvia Stacchiotti and Silvana Pilotti
    Citation: Journal of Translational Medicine 2013 11:237
  13. Clinical cardiac cell therapy using autologous somatic stem cells is restricted by age and disease-associated impairment of stem cell function. Juvenile cells possibly represent a more potent alternative, but ...

    Authors: Kristin Klose, Rajika Roy, Andreja Brodarac, Andreas Kurtz, Andrea Ode, Kyung-Sun Kang, Karen Bieback, Yeong-Hoon Choi and Christof Stamm
    Citation: Journal of Translational Medicine 2013 11:236
  14. Azathiopurine (AZA) is efficacious for maintenance remission of Crohn’s disease (CD) at the standard dose of 2.0-2.5 mg/kg for Caucasian. It has been reported that the lower dose (1.0-2.0 mg/kg) in some Asian ...

    Authors: Jianghong Wu, Yan Gao, Chuanhua Yang, Xueqing Yang, Xuhang Li and Shudong Xiao
    Citation: Journal of Translational Medicine 2013 11:235
  15. Due to known limitations of liver biopsy, reliable non-invasive serum biomarkers for chronic liver diseases are needed. We performed serum peptidomics for such investigation in compensated chronic hepatitis B ...

    Authors: Ming-Yi Xu, Xiao-Fang Jia, Ying Qu, Rui-Dan Zheng, Zheng-Hong Yuan, Hong-Lei Weng, Steven Dooley, Xing-Peng Wang, Li-Jun Zhang and Lun-Gen Lu
    Citation: Journal of Translational Medicine 2013 11:234
  16. Resistin increases during several inflammatory diseases and after intracerebral bleeding or head trauma. Resistin activates the endothelium and may initiate an inflammatory response. No data are available on r...

    Authors: Simona Oltean, Rille Pullerits, Anne Flodén, Michael Olausson and Mihai Oltean
    Citation: Journal of Translational Medicine 2013 11:233
  17. Oct4 is a major transcription factor related to stem cell self-renewal and differentiation. To fulfill its functions, it must be able to enter the nucleus and remain there to affect transcription. KPNA2, a mem...

    Authors: Xiao-Lei Li, Lan-Ling Jia, Mu-Mu Shi, Xin Li, Zhong-Hua Li, Hui-Feng Li, En-Hua Wang and Xin-Shan Jia
    Citation: Journal of Translational Medicine 2013 11:232
  18. 5-fluorouracil (5-FU) and cisplatin (CDDP) are used to enhance radiotherapy (RT) effect for head and neck (HN) cancers. However, the effect of local RT on systemic chemotherapeutics remains unclear. Here, we e...

    Authors: Chen-Hsi Hsieh, Mei-Ling Hou, Meng-Hsuan Chiang, Hung-Chi Tai, Hui-Ju Tien, Li-Ying Wang, Tung-Hu Tsai and Yu-Jen Chen
    Citation: Journal of Translational Medicine 2013 11:231
  19. Peripheral arterial disease (PAD), a manifestation of systemic atherosclerosis that produces blockages in arteries supplying the legs, affects an estimated 27 million people in Europe and North America. Increa...

    Authors: Dustin J Weiss, George P Casale, Panagiotis Koutakis, Aikaterini A Nella, Stanley A Swanson, Zhen Zhu, Dimitrios Miserlis, Jason M Johanning and Iraklis I Pipinos
    Citation: Journal of Translational Medicine 2013 11:230
  20. Angiotensin-converting enzyme 2 (ACE2), a monocarboxypeptidase which metabolizes angiotensin II (Ang II) to generate Ang-(1–7), has been shown to prevent cardiac hypertrophy and injury but the mechanism remain...

    Authors: Zhen-Zhou Zhang, Qian-Hui Shang, Hai-Yan Jin, Bei Song, Gavin Y Oudit, Lin Lu, Tong Zhou, Ying-Le Xu, Ping-Jin Gao, Ding-Liang Zhu, Josef M Penninger and Jiu-Chang Zhong
    Citation: Journal of Translational Medicine 2013 11:229
  21. To determine whether the functional effects of oral supplementation with Saffron, a natural compound that proved to be neuroprotective in early age-related macular degeneration, are influenced by complement fa...

    Authors: Dario Marangoni, Benedetto Falsini, Marco Piccardi, Lucia Ambrosio, Angelo Maria Minnella, Maria Cristina Savastano, Silvia Bisti, Rita Maccarone, Antonello Fadda, Enrica Mello, Paola Concolino and Ettore Capoluongo
    Citation: Journal of Translational Medicine 2013 11:228
  22. The presence of endothelial dysfunction (ED) constitutes an early risk factor for cardiovascular disease (CVD) in children. Nitric oxide (NO) and endothelin (EDN) are generated in endothelial cells and are cri...

    Authors: Siriporn Chatsuriyawong, David Gozal, Leila Kheirandish-Gozal, Rakesh Bhattacharjee, Ahamed A Khalyfa, Yang Wang, Hakon Hakonarson, Brendan Keating, Wasana Sukhumsirichart and Abdelnaby Khalyfa
    Citation: Journal of Translational Medicine 2013 11:227
  23. Primary cutaneous lymphomas (CLs), characterized by an accumulation of clonal T or B lymphocytes preferentially localized in the skin, have been successfully treated with interferons (IFNs) which counterbalanc...

    Authors: Nathalie Accart, Mirjana Urosevic-Maiwald, Reinhard Dummer, Vincent Bataille, Nadine Kehrer, Cristina Niculescu, Jean-Marc Limacher, Marie-Pierre Chenard, Jean-Yves Bonnefoy and Ronald Rooke
    Citation: Journal of Translational Medicine 2013 11:226
  24. Long non-coding RNAs (lncRNAs) are prevalently transcribed in the genome yet their potential roles in human cancers are not well understood. The aim of the present study was to determine the lncRNA expression ...

    Authors: Haojun Song, Weiliang Sun, Guoliang Ye, Xiaoyun Ding, Zhong Liu, Sijie Zhang, Tian Xia, Bingxiu Xiao, Yang Xi and Junming Guo
    Citation: Journal of Translational Medicine 2013 11:225
  25. Antibodies binding to citrullinated proteins are a frequent finding in rheumatoid arthritis patients and may precede the onset of clinical symptoms several years. The antibodies are a predisposing factor for b...

    Authors: Sanna Turunen, Marja-Kaisa Koivula, Jukka Melkko, Eeva Alasaarela, Petri Lehenkari and Juha Risteli
    Citation: Journal of Translational Medicine 2013 11:224
  26. Clinical studies have shown that radiotherapy increases the risk of cardiovascular disease at irradiated sites years after exposure. However, there is a lack of biological explanations in humans. We therefore ...

    Authors: Tinna Christersdottir Björklund, Sarah-Jayne Reilly, Caroline Gahm, Barbara Bottazzi, Alberto Mantovani, Per Tornvall and Martin Halle
    Citation: Journal of Translational Medicine 2013 11:223
  27. Previous study demonstrated that miR-133a was released into blood from injured myocardium in cardiovascular diseases. However, the dynamic change of circulating miR-133a level in the early phase of acute myoca...

    Authors: Feng Wang, Guangwen Long, Chunxia Zhao, Huaping Li, Sandip Chaugai, Yan Wang, Chen Chen and Dao Wen Wang
    Citation: Journal of Translational Medicine 2013 11:222
  28. Piezosurgery is an osteotomy system used in medical and dental surgery. Manystudies have proven clinical advantages of piezosurgery in terms of quality ofcut, maneuverability, ease of use, and safety. However,...

    Authors: Jônatas Caldeira Esteves, Elcio Marcantonio Jr, Ana Paula de Souza Faloni, Fernanda Regina Godoy Rocha, Rosemary Adriana Marcantonio, Katarzyna Wilk and Giuseppe Intini
    Citation: Journal of Translational Medicine 2013 11:221
  29. The control of Mycobacterium tuberculosis (Mtb) infection begins with the recognition of mycobacterial structural components by toll like receptors (TLRs) and other pattern recognition receptors. Our objective wa...

    Authors: Diana Torres-García, Alfredo Cruz-Lagunas, Ma Cecilia García-Sancho Figueroa, Rosario Fernández-Plata, Renata Baez-Saldaña, Criselda Mendoza-Milla, Rodrigo Barquera, Aida Carrera-Eusebio, Salomón Ramírez-Bravo, Lizeth Campos, Javier Angeles, Gilberto Vargas-Alarcón, Julio Granados, Radha Gopal, Shabaana A Khader, Edmond J Yunis…
    Citation: Journal of Translational Medicine 2013 11:220
  30. Adipose-derived stromal cells (ASCs) stimulated with vascular endothelial growth factor (VEGF) and serum-deprived, are applied in the first in-man double-blind placebo-controlled MyStromalCell Trial, as a nove...

    Authors: Bjarke Follin, Josefine Tratwal, Mandana Haack-Sørensen, Jens Jørgen Elberg, Jens Kastrup and Annette Ekblond
    Citation: Journal of Translational Medicine 2013 11:219
  31. Targeted therapies directed at commonly overexpressed pathways in melanoma have clinical activity in numerous trials. Little is known about how these therapies influence microRNA (miRNA) expression, particular...

    Authors: Aubrey G Wagenseller, Amber Shada, Kevin M D’Auria, Cheryl Murphy, Dandan Sun, Kerrington R Molhoek, Jason A Papin, Anindya Dutta and Craig L Slingluff Jr
    Citation: Journal of Translational Medicine 2013 11:218
  32. Special AT rich sequence binding protein 1 (SATB1) plays a crucial role in the biology of various types of human cancer. However, the role of SATB1 in human nasopharyngeal carcinoma (NPC) remains unknown. In t...

    Authors: Zhihua Shen, Yumei Zeng, Junli Guo, Yanxia Wu, Xiaofan Jiang, Ranran Ding, Changli Wu, Rujia Li, Botao Luo, Chao Zeng, Hanguo Jiang and Wei Jie
    Citation: Journal of Translational Medicine 2013 11:217
  33. The brain cancer stem cell (CSC) model describes a small subset of glioma cells as being responsible for tumor initiation, conferring therapy resistance and tumor recurrence. In brain CSC, the PI3-K/AKT and the R...

    Authors: Klaus Mantwill, Ulrike Naumann, Janina Seznec, Vroni Girbinger, Hermann Lage, Pawel Surowiak, Dagmar Beier, Michel Mittelbronn, Jürgen Schlegel and Per Sonne Holm
    Citation: Journal of Translational Medicine 2013 11:216
  34. T-cell immunoglobulin and mucin domain 3 (TIM-3) is known as a negative immune regulator and emerging data have implicated TIM-3 a pivotal role in suppressing antitumor immunity. The co-stimulatory receptor CD...

    Authors: Zhiqiang Guo, Dali Cheng, Zhijun Xia, Meng Luan, Liangliang Wu, Gang Wang and Shulan Zhang
    Citation: Journal of Translational Medicine 2013 11:215
  35. Single circulating tumor cells (CTCs) or circulating tumor microemboli (CTMs) are potential biomarkers of renal cell cancer (RCC), however studies of CTCs/CTMs in RCC are limited. In this pilot study we aimed ...

    Authors: Amin El-Heliebi, Thomas Kroneis, Evelyn Zöhrer, Johannes Haybaeck, Katja Fischereder, Karin Kampel-Kettner, Richard Zigeuner, Hannelore Pock, Regina Riedl, Rudolf Stauber, Jochen Bernd Geigl, Berthold Huppertz, Peter Sedlmayr and Carolin Lackner
    Citation: Journal of Translational Medicine 2013 11:214
  36. Malignant peripheral nerve sheath tumors (MPNST) are rare highly aggressive sarcomas that affect 8-13% of people with neurofibromatosis type 1. The prognosis for patients with MPNST is very poor. Despite TOP2A...

    Authors: Jacqueline D Peacock, David Cherba, Kevin Kampfschulte, Mallory K Smith, Noel R Monks, Craig P Webb and Matthew Steensma
    Citation: Journal of Translational Medicine 2013 11:213
  37. Gastric cancer is highly aggressive disease. Despite advances in diagnosis and therapy, the prognosis is still poor. Various genetic and molecular alterations are found in gastric cancer that underlies the mal...

    Authors: Javed Akhtar, Zhou Wang, Zhi Ping Zhang and Ming Ming Bi
    Citation: Journal of Translational Medicine 2013 11:212
  38. Therapeutic gene transfer is of significant value to elaborate efficient, durable treatments against human osteoarthritis (OA), a slow, progressive, and irreversible disorder for which there is no cure to date.

    Authors: Jagadeesh K Venkatesan, Ana Rey-Rico, Gertrud Schmitt, Anna Wezel, Henning Madry and Magali Cucchiarini
    Citation: Journal of Translational Medicine 2013 11:211
  39. The naked caspase-3 small interfering RNA (siRNA) infused into the renal artery during cold preservation was effective, but did not protect auto-transplant porcine kidneys with increased inflammation and apopt...

    Authors: Cheng Yang, Long Li, Yinjia Xue, Zitong Zhao, Tian Zhao, Yichen Jia, Ruiming Rong, Ming Xu, Michael L Nicholson, Tongyu Zhu and Bin Yang
    Citation: Journal of Translational Medicine 2013 11:210
  40. M3 muscarinic acetylcholine receptor (M3-mAChR) is stably expressed in the myocardium, but its pathophysiological role remains largely undefined. This study aimed to investigate the role of M3-mAChR in cardiac hy...

    Authors: Yan Liu, Shu Wang, Chao Wang, Haoxin Song, Hongmei Han, Pengzhou Hang, Yanan Jiang, Lanlan Wei, Rong Huo, Lihua Sun, Xu Gao, Yanjie Lu and Zhimin Du
    Citation: Journal of Translational Medicine 2013 11:209
  41. Vascular smooth muscle cells (SMC) are central to arterial structure and function yet their involvement in the progression of abdominal aortic aneurysm (AAA) disease is not well studied. The progressive and si...

    Authors: Kirsten Riches, Timothy G Angelini, Gurprit S Mudhar, Jean Kaye, Emily Clark, Marc A Bailey, Soroush Sohrabi, Sotirios Korossis, Peter G Walker, D Julian A Scott and Karen E Porter
    Citation: Journal of Translational Medicine 2013 11:208
  42. Ulcerative colitis (UC) is the most common form of inflammatory bowel disease in the USA. A key component of UC is the increase in inflammatory angiogenesis of the colon during active disease. This increase is...

    Authors: Walter E Cromer, Chaitanya V Ganta, Mihir Patel, James Traylor, Christopher G Kevil, J Steven Alexander and J Michael Mathis
    Citation: Journal of Translational Medicine 2013 11:207
  43. The prevalence of vitamin D deficiency among patients with cancer has been previously reported. Because vitamin D is fat soluble, patients with pancreatic adenocarcinoma may have an especially high risk of vit...

    Authors: May Cho, Parvin F Peddi, Kevin Ding, Ling Chen, Denise Thomas, Jian Wang, Albert C Lockhart, Benjamin Tan and Andrea Wang-Gillam
    Citation: Journal of Translational Medicine 2013 11:206
  44. Ultraviolet-inactivated, replication-defective Sendai virus particles (Z strain) have displayed antitumor effect through enhancing the immune responses or inducing apoptosis in a variety of carcinomas. Sendai ...

    Authors: Liying Shi, Jun Chen, Qiping Zhong, Mei Li, Peng Geng, Jianmin He, Zhe Han, Mingwei Sheng and Hua Tang
    Citation: Journal of Translational Medicine 2013 11:205
  45. Forkhead box transcription factor 1 (FOXM1) has been reported to overexpress and correlate with pathogenesis in a variety of human malignancies. However, little research has been done to investigate its clinic...

    Authors: Xiaoxiao Li, Wensheng Qiu, Bin Liu, Ruyong Yao, Shihai Liu, Yasai Yao and Jun Liang
    Citation: Journal of Translational Medicine 2013 11:204
  46. Recent studies have indicated that the expression of endothelin A receptor (ETAR) and chemokine receptor 4 (CXCR4) could be used as an indicator of the metastatic potential of nasopharyngeal carcinoma (NPC). T...

    Authors: Dong-Hua Luo, Qiu-Yan Chen, Huai Liu, Li-Hua Xu, Hui-Zhong Zhang, Lu Zhang, Lin-Quan Tang, Hao-Yuan Mo, Pei-Yu Huang, Xiang Guo and Hai-Qiang Mai
    Citation: Journal of Translational Medicine 2013 11:203
  47. Prevalence and distribution of pathogenetic mutations in BRAF and NRAS genes were evaluated in multiple melanoma lesions from patients with different geographical origin within the same Italian population.

    Authors: Maria Colombino, Amelia Lissia, Mariaelena Capone, Vincenzo De Giorgi, Daniela Massi, Ignazio Stanganelli, Ester Fonsatti, Michele Maio, Gerardo Botti, Corrado Caracò, Nicola Mozzillo, Paolo A Ascierto, Antonio Cossu and Giuseppe Palmieri
    Citation: Journal of Translational Medicine 2013 11:202
  48. Osteoporosis is characterised by low bone mass and structural deterioration of bone tissue, resulting in increased fragility and susceptibility to fracture. Osteoporotic fractures are a significant cause of mo...

    Authors: Gillian Wheater, Mohsen Elshahaly, Stephen P Tuck, Harish K Datta and Jacob M van Laar
    Citation: Journal of Translational Medicine 2013 11:201
  49. Longikaurin A is a natural ent-kaurene diterpenoid isolated from Isodon genus. The ent-kaurene diterpenoids isolated from medicinal plants have been shown to have anti-disease effects. The present study was desig...

    Authors: Qing-Feng Zou, Ji-Ke Du, Hua Zhang, Hong-Bo Wang, Ze-Dong Hu, Shu-Peng Chen, Yong Du, Man-Zhi Li, Dan Xie, Juan Zou, Han-Dong Sun, Jian-Xin Pu and Mu-Sheng Zeng
    Citation: Journal of Translational Medicine 2013 11:200
  50. Effective eradication of high-risk primary prostate cancer (HRPCa) could significantly decrease mortality from prostate cancer. However, the discovery of curative therapies for HRPCa is hampered by the lack of...

    Authors: Hongjuan Zhao, Alan Thong, Rosalie Nolley, Stephen W Reese, Jennifer Santos, Alexandre Ingels and Donna M Peehl
    Citation: Journal of Translational Medicine 2013 11:199

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