Atkins MB: Interleukin-2: clinical applications. Semin Oncol. 2002, 29: 12-17. 10.1053/sonc.2002.33077.
Article
CAS
PubMed
Google Scholar
Yang JC, Sherry RM, Steinberg SM, Topalian SL, Schwartzentruber DJ, Hwu P, Seipp CA, Rogers-Freezer L, Morton KE, White DE, Liewehr DJ, Merino MJ, Rosenberg SA: Randomized Study of High-Dose and Low-Dose Interleukin-2 in Patients With Metastatic Renal Cancer. J Clin Oncol. 2003, 21: 3127-3132. 10.1200/JCO.2003.02.122.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rosenberg SA, Yang JC, White DE, Steinberg SM: Durability of complete responses in patients with metastatic cancer treated with high-dose interleukin-2: identification of the antigens mediating response. Ann Surg. 1998, 228: 307-319. 10.1097/00000658-199809000-00004.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rosenberg SA, Yang JC, Schwartzentruber DJ, Hwu P, Marincola FM, Topalian SL, Restifo NP, Dudley ME, Schwarz SL, Spiess PJ, Wunderlich JR, Parkhurst MR, Kawakami Y, Seipp CA, Einhorn JH, White DE: Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat Med. 1998, 4: 321-327. 10.1038/nm0398-321.
Article
PubMed Central
CAS
PubMed
Google Scholar
Neumann E, Engelsberg A, Decker J, Storkel S, Jaeger E, Huber C, Seliger B: Heterogeneous Expression of the Tumor-associated Antigens RAGE-1, PRAME, and Glycoprotein 75 in Human Renal Cell Carcinoma: Candidates for T-Cell-based Immunotherapies?. Cancer Res. 1998, 58: 4090-4095.
CAS
PubMed
Google Scholar
Griffiths RW, Gilham DE, Dangoor A, Ramani V, Clarke NW, Stern PL, Hawkins RE: Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: a potential target for T-cell-based immunotherapy. Br J Cancer. 2005, 93: 670-677. 10.1038/sj.bjc.6602776.
Article
PubMed Central
CAS
PubMed
Google Scholar
Starzynska T, Rahi V, Stern PL: The expression of 5T4 antigen in colorectal and gastric carcinoma. Br J Cancer. 1992, 66: 867-869.
Article
PubMed Central
CAS
PubMed
Google Scholar
Starzynska T, Marsh PJ, Schofield PF, Roberts SA, Myers KA, Stern PL: Prognostic significance of 5T4 oncofetal antigen expression in colorectal carcinoma. Br J Cancer. 1994, 69: 899-902.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wrigley E, McGown AT, Rennison J, Swindell R, Crowther D, Starzynska T, Stern PL: 5T4 oncofetal antigen expression in ovarian carcinoma. Int J Gynecol Cancer. 1995, 5: 269-274. 10.1046/j.1525-1438.1995.05040269.x.
Article
PubMed
Google Scholar
Woods AM, Wang WW, Shaw DM, Ward CM, Carroll MW, Rees BR, Stern PL: Characterization of the murine 5T4 oncofoetal antigen: a target for immunotherapy in cancer. Biochem J. 2002, 366: 353-365.
Article
PubMed Central
CAS
PubMed
Google Scholar
Harrop R, Connolly N, Redchenko I, Valle J, Saunders M, Ryan MG, Myers KA, Drury N, Kingsman SM, Hawkins RE, Carroll MW: Vaccination of colorectal cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: a phase I/II trial. Clin Cancer Res. 2006, 12: 3416-3424. 10.1158/1078-0432.CCR-05-2732.
Article
CAS
PubMed
Google Scholar
Harrop R, Ryan MG, Myers KA, Redchenko I, Kingsman SM, Carroll MW: Active treatment of murine tumors with a highly attenuated vaccinia virus expressing the tumor associated antigen 5T4 (TroVax) is CD4+ T cell dependent and antibody mediated. Cancer Immunol Immunother. 2006, 55: 1081-1090. 10.1007/s00262-005-0096-4.
Article
CAS
PubMed
Google Scholar
Schlom J, Gulley JL, Arlen PM: Paradigm Shifts in Cancer Vaccine Therapy. Experimental Biology and Medicine. 2008, 233: 522-534. 10.3181/0708-MR-226.
Article
CAS
PubMed
Google Scholar
Harrop R, Drury N, Shingler W, Chikoti P, Redchenko I, Carroll MW, Kingsman SM, Naylor S, Melcher A, Nicholls J, Wassan H, Habib N, Anthoney A: Vaccination of colorectal cancer patients with modified vaccinia ankara encoding the tumor antigen 5T4 (TroVax) given alongside chemotherapy induces potent immune responses. Clin Cancer Res. 2007, 13: 4487-4494. 10.1158/1078-0432.CCR-07-0704.
Article
CAS
PubMed
Google Scholar
Cesana GC, DeRaffele G, Cohen S, Moroziewicz D, Mitcham J, Stoutenburg J, Cheung K, Hesdorffer C, Kim-Schulze S, Kaufman HL: Characterization of CD4+CD25+ regulatory T cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma. J Clin Oncol. 2006, 24: 1169-1177. 10.1200/JCO.2005.03.6830.
Article
CAS
PubMed
Google Scholar
Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer M, Koup RA: Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods. 2003, 281: 65-78. 10.1016/S0022-1759(03)00265-5.
Article
CAS
PubMed
Google Scholar
Mittendorf EA, Storrer CE, Shriver CD, Ponniah S, Peoples GE: Evaluation of the CD107 cytotoxicity assay for the detection of cytolytic CD8+ cells recognizing HER2/neu vaccine peptides. Breast Cancer Res Treat. 2005, 92: 85-93. 10.1007/s10549-005-0988-1.
Article
CAS
PubMed
Google Scholar
Saenger YM, Wolchok JD: The heterogeneity of the kinetics of response to ipilimumab in metastatic melanoma: patient cases. Cancer Immun. 2008, 8: 1-
PubMed Central
PubMed
Google Scholar
Schlom J, Arlen PM, Gulley JL: Cancer vaccines: moving beyond current paradigms. Clin Cancer Res. 2007, 13: 3776-3782. 10.1158/1078-0432.CCR-07-0588.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pantuck AJ, Belldegrun AS, Figlin RA: Nephrectomy and interleukin-2 for metastatic renal-cell carcinoma. N Engl J Med. 2001, 345: 1711-1712. 10.1056/NEJM200112063452317.
Article
CAS
PubMed
Google Scholar
Diner EK, Linehan M, Walther M: Response of papillary renal cell carcinoma in a solitary kidney to high dose interleukin therapy. International Journal of Urology. 2005, 12: 996-997. 10.1111/j.1442-2042.2005.01193.x.
Article
PubMed
Google Scholar
Rochlitz C, Figlin R, Squiban P, Salzberg M, Pless M, Herrmann R, Tartour E, Zhao Y, Bizouarne N, Baudin M, Acres B: Phase I immunotherapy with a modified vaccinia virus (MVA) expressing human MUC1 as antigen-specific immunotherapy in patients with MUC1-positive advanced cancer. J Gene Med. 2003, 5: 690-699. 10.1002/jgm.397.
Article
CAS
PubMed
Google Scholar
Bromwich EJ, McArdle PA, Canna K, McMillan DC, McNicol A-M, Brown M, M A: The relationship between T-lymphocyte infiltration, stage, tumour grade and survival in patients undergoing curative surgery for renal cell cancer. British Journal of Cancer. 2003, 89: 1906-1908. 10.1038/sj.bjc.6601400.
Article
PubMed Central
CAS
PubMed
Google Scholar
Siddiqui SA, Frigola X, Bonne-Annee S, Mercader M, Kuntz SM, Krambeck AE, Sengupta S, Dong H, Cheville JC, Lohse CM, Krco , Christopher J, Webster WS, Leibovich BC, Blute ML, Knutson KL, Kwon ED: Tumor-Infiltrating Foxp3-CD4+CD25+ T Cells Predict Poor Survival in Renal Cell Carcinoma. Clin Cancer Res. 2007, 13: 2075-2081. 10.1158/1078-0432.CCR-06-2139.
Article
CAS
PubMed
Google Scholar
Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM: BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003, 4: 670-679. 10.1038/ni944.
Article
CAS
PubMed
Google Scholar
Chen L: Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol. 2004, 4: 336-347. 10.1038/nri1349.
Article
CAS
PubMed
Google Scholar
Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, Mackey EW, Miller JD, Leslie AJ, DePierres C, Mncube Z, Duraiswamy J, Zhu B, Eichbaum Q, Altfeld M, Wherry EJ, Coovadia HM, Goulder PJ, Klenerman P, Ahmed R, Freeman GJ, Walker BD: PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 2006, 443: 350-354. 10.1038/nature05115.
Article
CAS
PubMed
Google Scholar
Bui JD, Uppaluri R, Hsieh CS, Schreiber RD: Comparative analysis of regulatory and effector T cells in progressively growing versus rejecting tumors of similar origins. Cancer Res. 2006, 66: 7301-7309. 10.1158/0008-5472.CAN-06-0556.
Article
CAS
PubMed
Google Scholar