|
Patient Number
|
Peak 5T4 polyclonal precursor frequencies
|
ORR (month)
|
|---|
| |
Time point (week)
|
Peptides alone
|
Time Point (week)
|
Protein + Peptides
| |
|
1
|
-
|
< 1/200,000
|
-
|
< 1/200,000
|
PD
|
|
2
|
-
|
< 1/200,000
|
3
|
1/19,231
|
PD
|
|
3
|
-
|
< 1/200,000
|
-
|
< 1/200,000
|
PD
|
|
5
|
55
|
1/12,048
|
55
|
1/1,701
|
Surgical CR(50+)
|
|
6
|
26
|
1/21,277
|
26
|
1/21,277
|
SD (13)
|
|
7
|
29
|
1/2,113
|
29
|
1/2,113
|
SD (9)
|
|
8
|
-
|
< 1/200,000
|
-
|
< 1/200,000
|
PD
|
|
9
|
105
|
1/993
|
105
|
1/993
|
Surgical CR(54+)
|
|
10
|
-
|
< 1/200,000
|
-
|
< 1/200,000
|
PD
|
|
11
|
-
|
< 1/200,000
|
9
|
1/12,500
|
SD (2)
|
|
12
|
-
|
< 1/200,000
|
-
|
< 1/200,000
|
PD
|
|
13
|
15
|
1/11,765
|
15
|
1/11,765
|
SD (1)
|
|
14
|
-
|
< 1/200,000
|
-
|
< 1/200,000
|
PD
|
|
15
|
-
|
< 1/200,000
|
92
|
1/19,231
|
SD (18)
|
|
16
|
-
|
< 1/200,000
|
-
|
< 1/200,000
|
SD (2)
|
|
17
|
78
|
1/7,042
|
78
|
1/4,132
|
SD (16)
|
|
19
|
-
|
< 1/200,000
|
20
|
1/20,833
|
SD (5)
|
|
20
|
-
|
< 1/200,000
|
-
|
< 1/200,000
|
PD
|
|
21
|
-
|
< 1/200,000
|
-
|
< 1/200,000
|
PD
|
|
22
|
9
|
1/12,821
|
9
|
1/12,821
|
PD
|
|
23
|
-
|
< 1/200,000
|
-
|
< 1/200,000
|
Surgical CR (13+)
|
|
24
|
-
|
< 1/200,000
|
6
|
1/12,048
|
SD (3.5)
|
|
25
|
-
|
< 1/200,000
|
3
|
1/18,868
|
PD
|
- The peak 5T4 specific responses detected at any time point to 5T4 peptides or 5T4 peptide plus protein. *; no detection of 5T4 responses. Positive responses are indicated as bold type.
