Table 3 Antigen specific T cell responses
Patient Number | Peak 5T4 polyclonal precursor frequencies | ORR (month) | |||
|---|---|---|---|---|---|
| Â | Time point (week) | Peptides alone | Time Point (week) | Protein + Peptides | Â |
1 | - | < 1/200,000 | - | < 1/200,000 | PD |
2 | - | < 1/200,000 | 3 | 1/19,231 | PD |
3 | - | < 1/200,000 | - | < 1/200,000 | PD |
5 | 55 | 1/12,048 | 55 | 1/1,701 | Surgical CR(50+) |
6 | 26 | 1/21,277 | 26 | 1/21,277 | SD (13) |
7 | 29 | 1/2,113 | 29 | 1/2,113 | SD (9) |
8 | - | < 1/200,000 | - | < 1/200,000 | PD |
9 | 105 | 1/993 | 105 | 1/993 | Surgical CR(54+) |
10 | - | < 1/200,000 | - | < 1/200,000 | PD |
11 | - | < 1/200,000 | 9 | 1/12,500 | SD (2) |
12 | - | < 1/200,000 | - | < 1/200,000 | PD |
13 | 15 | 1/11,765 | 15 | 1/11,765 | SD (1) |
14 | - | < 1/200,000 | - | < 1/200,000 | PD |
15 | - | < 1/200,000 | 92 | 1/19,231 | SD (18) |
16 | - | < 1/200,000 | - | < 1/200,000 | SD (2) |
17 | 78 | 1/7,042 | 78 | 1/4,132 | SD (16) |
19 | - | < 1/200,000 | 20 | 1/20,833 | SD (5) |
20 | - | < 1/200,000 | - | < 1/200,000 | PD |
21 | - | < 1/200,000 | - | < 1/200,000 | PD |
22 | 9 | 1/12,821 | 9 | 1/12,821 | PD |
23 | - | < 1/200,000 | - | < 1/200,000 | Surgical CR (13+) |
24 | - | < 1/200,000 | 6 | 1/12,048 | SD (3.5) |
25 | - | < 1/200,000 | 3 | 1/18,868 | PD |