Table 2 Adverse events related to vaccine and IL-2
Vaccine-related AEs | Maximum Grade | Patients | ||
|---|---|---|---|---|
System | Adverse Events | Â | N = 25 | % |
Constitutional | Fever | 1 | 8 | 32 |
| Â | Pain at injection site | 1 | 4 | 16 |
| Â | Injection site reaction | 1 | 3 | 12 |
| Â | Myalgia | 1 | 1 | 4 |
| Â | Chills | 1 | 1 | 4 |
IL-2-related AEs | Â | Â | Â | |
Cardiovascular | Cardiopulmonary arrest | 4 | 1 | 4 |
| Â | Elevated troponin | 4 | 1 | 4 |
| Â | Hypotension | 4 | 9 | 36 |
| Â | Ventricular tachycardia | 3 | 1 | 4 |
| Â | Acidosis | 4 | 1 | 4 |
Electrolyte | Hyperglycemia | 3 | 4 | 16 |
| Â | Hypocalcemia | 3 | 1 | 4 |
| Â | Hyponatremia | 3 | 11 | 44 |
| Â | Hypophosphatemia | 3 | 3 | 12 |
Gastro-intestinal | Ischemic bowel | 4 | 1 | 4 |
Hematologic | Anemia | 3 | 2 | 8 |
| Â | Neutropenia | 3 | 1 | 4 |
| Â | Thrombocytopenia | 3 | 4 | 16 |
Hepatic | Elevated transaminases | 3 | 1 | 4 |
| Â | Hyperbilirubinemia | 3 | 3 | 12 |
Neurologic | Confusion | 3 | 3 | 12 |
| Â | Syncope | 3 | 2 | 8 |
Pulmonary | Dyspnea | 3 | 1 | 4 |
Renal | Elevated creatinine | 3 | 22 | 88 |
| Â | Oliguria | 3 | 2 | 8 |
Systemic | Fatigue | 3 | 1 | 4 |