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Table 4 T cell responses to CEF and MVA antigens by IFN-γ ELISPOT

From: Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma

Patient Number Antigen Peak Ag Specific T cell Precursor Frequencies
   Pre Post
1 CEF ND 1/1,299
  MVA ND 1/11,364
2 CEF ND 1/10,929
  MVA ND 1/4,926
3 CEF ND ND
  MVA 1/18,182 1/10,341
5 CEF ND 1/1,658
  MVA ND 1/3,993
6 CEF < 1/200,000 < 1/200,000
  MVA 1/4,411 1/2,629
7 CEF ND 1/2,084
  MVA ND 1/1,935
8 CEF 1/1,613 1/1,126
  MVA < 1/200,000 1/1770
9 CEF 1/1,040 1/956
  MVA 1/5,263 1/1,452
10 CEF < 1/200,000 < 1/200,000
  MVA < 1/200,000 1/3,442
11 CEF 1/5,882 1/2,362
  MVA 1/3,030 1/2,135
12 CEF ND < 1/200,000
  MVA < 1/200,000 1/45455
13 CEF < 1/200,000 < 1/200,000
  MVA < 1/200,000 1/29,630
14 CEF 1/631 1/619
  MVA 1/928 1/2,112
15 CEF 1/1,357 1/1,445
  MVA 1/3,731 1/2,901
16 CEF 1/2,070 1/2,316
  MVA 1/2,618 1/2,685
17 CEF ND 1/10,216
  MVA ND 1/5,405
19 CEF 1/1,543 1/2,335
  MVA 1/5,618 1/2,273
20 CEF < 1/200,000 < 1/200,000
  MVA 1/868 1/984
21 CEF < 1/200,000 < 1/200,000
  MVA 1/1,230 1/945
22 CEF ND 1/1,789
  MVA ND 1/1,988
23 CEF 1/629 1/1,056
  MVA 1/5,208 1/4,561
24 CEF 1/870 1/1,078
  MVA 1/1,923 1/23,256
25 CEF 1/1,538 1/1,161
  MVA 1/7,143 1/3,697
  1. Abbreviation: ND, not detected
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Journal of Translational Medicine

ISSN: 1479-5876

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