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  1. Authors: JCA Broen, P Dieude, M C Vonk, L Beretta, B Rueda, A Herrick, J Worthington, N Hunzelmann, G Riemekasten, H Kiener, R Scorza, C P Simeon, V Fonollosa, P Carreira, N Ortego-Centeno, M A Gonzalez-Gay…
    Citation: Journal of Translational Medicine 2010 8(Suppl 1):P47

    This article is part of a Supplement: Volume 8 Supplement 1

  2. Authors: L Bossini-Castillo, JCA Broen, C P Simeon, L Beretta, M C Vonk, N Ortego-Centeno, G Espinosa, P Carreira, M T Camps, N Navarrete, M F González-Escribano, E Vicente-Rabaneda, L Rodríguez, C Tolosa, J A Román-Ivorra, I Gómez-Gracia…
    Citation: Journal of Translational Medicine 2010 8(Suppl 1):P5

    This article is part of a Supplement: Volume 8 Supplement 1

  3. Most colorectal carcinomas are driven by an activation of the canonical Wnt signalling pathway, which promotes the expression of multiple target genes mediating proliferation inavasion and invasion. Upon activ...

    Authors: Lydia Kriegl, David Horst, Jana A Reiche, Jutta Engel, Thomas Kirchner and Andreas Jung
    Citation: Journal of Translational Medicine 2010 8:123
  4. To evaluate fluorescence cystoscopy with hexaminolevulinate (HAL) in the early detection of dysplasia (DYS) and carcinoma in situ (CIS) in select high risk patients.

    Authors: Salvatore Blanco, Marco Raber, Biagio Eugenio Leone, Luca Nespoli and Marco Grasso
    Citation: Journal of Translational Medicine 2010 8:122
  5. Recent preclinical adoptive immunotherapy studies in murine models prompt to employ "proper" rather than "as many as possible" antigen-specific T cells to gain better therapeutic results. Ideally, "proper" T c...

    Authors: Anna Merlo, Riccardo Turrini, Cristina Trento, Paola Zanovello, Riccardo Dolcetti and Antonio Rosato
    Citation: Journal of Translational Medicine 2010 8:121
  6. Growth hormone (GH) is an essential regulator of intrahepatic lipid metabolism by activating multiple complex hepatic signaling cascades. Here, we examined whether chronic exogenous GH administration (via gene...

    Authors: Ying Qin and Ya-ping Tian
    Citation: Journal of Translational Medicine 2010 8:120
  7. Culturing otospheres from dissociated organ of Corti is an appropriate starting point aiming at the development of cell therapy for hair cell loss. Although guinea pigs have been widely used as an excellent ex...

    Authors: Jeanne Oiticica, Luiz Carlos M Barboza-Junior, Ana Carla Batissoco, Karina Lezirovitz, Regina C Mingroni-Netto, Luciana A Haddad and Ricardo F Bento
    Citation: Journal of Translational Medicine 2010 8:119
  8. Zinc is important. It is the second most abundant trace metal with 2-4 grams in humans. It is an essential trace element, critical for cell growth, development and differentiation, DNA synthesis, RNA transcrip...

    Authors: Erica John, Thomas C Laskow, William J Buchser, Bruce R Pitt, Per H Basse, Lisa H Butterfield, Pawel Kalinski and Michael T Lotze
    Citation: Journal of Translational Medicine 2010 8:118
  9. Recent years have seen a growing interest in insulin-like growth factor 1 receptor (IGF1R) in medical oncology. Interesting data have been reported also on IGF1r in gastrointestinal stromal tumors (GISTs) espe...

    Authors: Maria A Pantaleo, Annalisa Astolfi, Margherita Nannini and Guido Biasco
    Citation: Journal of Translational Medicine 2010 8:117
  10. DNA vaccines represent an attractive approach for cancer treatment by inducing active T cell and B cell immune responses to tumor antigens. Previous studies have shown that interleukin-13 receptor α2 chain (IL...

    Authors: Hideyuki Nakashima, Toshio Fujisawa, Syed R Husain and Raj K Puri
    Citation: Journal of Translational Medicine 2010 8:116
  11. Pegylated granulocyte colony-stimulating factor (G-CSF; pegfilgrastim) is a longer-acting form of G-CSF, whose effects on dendritic cell (DC) and regulatory T cell (Treg) mobilization, and on the in vivo and ex v...

    Authors: Giuseppina Bonanno, Annabella Procoli, Andrea Mariotti, Maria Corallo, Alessandro Perillo, Silvio Danese, Raimondo De Cristofaro, Giovanni Scambia and Sergio Rutella
    Citation: Journal of Translational Medicine 2010 8:114
  12. Peripheral immune tolerance requires a finely controlled balance between tolerance to self-antigens and protective immunity against enteric and invading pathogens. Self-reactive T cells sometimes escape thymic...

    Authors: Eva d'Hennezel, Mara Kornete and Ciriaco A Piccirillo
    Citation: Journal of Translational Medicine 2010 8:113
  13. Colorectal cancer can be efficiently treated when found at early stages, thus the search for novel markers is of paramount importance. Since inflammation is associated with cancer progression and angiogenesis,...

    Authors: Rosaria Cammarota, Valentina Bertolini, Giuseppina Pennesi, Eraldo O Bucci, Ornella Gottardi, Cecilia Garlanda, Luigi Laghi, Massimo C Barberis, Fausto Sessa, Douglas M Noonan and Adriana Albini
    Citation: Journal of Translational Medicine 2010 8:112
  14. The immune defects occurring in chronic lymphocytic leukemia are responsible for the frequent occurrence of infections and autoimmune phenomena, and may be involved in the initiation and maintenance of the mal...

    Authors: Marina Motta, Marco Chiarini, Claudia Ghidini, Cinzia Zanotti, Cinzia Lamorgese, Luigi Caimi, Giuseppe Rossi and Luisa Imberti
    Citation: Journal of Translational Medicine 2010 8:111
  15. Epidemiological, preclinical and clinical studies demonstrated that chronic inflammation induced by hepatitis C virus (HCV) is crucial in hepatocellular carcinogenesis. The interaction between hepatocytes and ...

    Authors: Giuseppe Castello, Susan Costantini and Stefania Scala
    Citation: Journal of Translational Medicine 2010 8:109
  16. Interferon is approved for adjuvant treatment of patients with stage IIb/III melanoma. The toxicity and uncertainty regarding survival benefits of interferon have qualified its acceptance, despite significant ...

    Authors: Helen Gogas, Urania Dafni, Henry Koon, Maria Spyropoulou-Vlachou, Yannis Metaxas, Elizabeth Buchbinder, Eirini Pectasides, Dimosthenis Tsoutsos, Aristidis Polyzos, Alexandros Stratigos, Christos Markopoulos, Petros Panagiotou, George Fountzilas, Ourania Castana, Pantelis Skarlos, Michael B Atkins…
    Citation: Journal of Translational Medicine 2010 8:108
  17. The existence of circulating tumor cells (CTCs) in peripheral blood as an indicator of tumor recurrence has not been clearly established, particularly for gastric cancer patients. We conducted a retrospective ...

    Authors: Miao-zhen Qiu, Zhuang-hua Li, Zhi-wei Zhou, Yu-hong Li, Zhi-qiang Wang, Feng-hua Wang, Peng Huang, Fahad Aziz, Dao-yuan Wang and Rui-hua Xu
    Citation: Journal of Translational Medicine 2010 8:107
  18. The complex data sets generated by higher-order polychromatic flow cytometry experiments are a challenge to analyze. Here we describe Exhaustive Expansion, a data analysis approach for deriving hundreds to tho...

    Authors: Janet C Siebert, Lian Wang, Daniel P Haley, Ann Romer, Bo Zheng, Wes Munsil, Kenton W Gregory and Edwin B Walker
    Citation: Journal of Translational Medicine 2010 8:106
  19. The ability to expand virus- or tumor-specific T cells without damaging their functional capabilities is critical for success adoptive transfer immunotherapy of patients with opportunistic infection or tumor. ...

    Authors: Yixin Li and Roger J Kurlander
    Citation: Journal of Translational Medicine 2010 8:104
  20. We previously reported that measuring circulating serum mRNAs using quantitative one-step real-time RT-PCR was clinically useful for detecting malignancies and determining prognosis. The aim of our study was t...

    Authors: Shunsaku Takahashi, Norimasa Miura, Tomomi Harada, ZhongZhi Wang, Xinhui Wang, Hideyuki Tsubokura, Yoshiaki Oshima, Junichi Hasegawa, Yoshimi Inagaki and Goshi Shiota
    Citation: Journal of Translational Medicine 2010 8:103
  21. Cancer invasion results from constant interactions between cancer cells and their microenvironment. Major components of the cancer microenvironment are stromal cells, infiltrating inflammatory cells, collagens...

    Authors: Chun-Wei Peng, Xiu-Li Liu, Xiong Liu and Yan Li
    Citation: Journal of Translational Medicine 2010 8:101
  22. Despite new additions to the standard of care therapy for high grade primary malignant brain tumors, the prognosis for patients with this disease is still poor. A small contingent of clinical researchers are f...

    Authors: Michelle J Hickey, Colin C Malone, Kate L Erickson, Martin R Jadus, Robert M Prins, Linda M Liau and Carol A Kruse
    Citation: Journal of Translational Medicine 2010 8:100
  23. Esophageal adenocarcinomas (EACs) arise due to gastroesophageal reflux, with Barrett's esophagus (BE) regarded as precancerous lesion. Matrix metalloproteinases (MMPs) might play a role during the multistep ca...

    Authors: Martin Grimm, Maria Lazariotou, Stefan Kircher, Luisa Stuermer, Christoph Reiber, Andreas Höfelmayr, Stefan Gattenlöhner, Christoph Otto, Christoph T Germer and Burkhard HA von Rahden
    Citation: Journal of Translational Medicine 2010 8:99
  24. Tumor immune responses are first generated and metastases often begin in tumor sentinel lymph nodes (TSLN). Therefore, it is important to promote tumor immunity within this microenvironment. Mifepristone (RU48...

    Authors: Claudia Raja Gabaglia, Alexandra DeLaney, Jennifer Gee, Ramesh Halder, Frank L Graham, Jack Gauldie, Eli E Sercarz and Todd A Braciak
    Citation: Journal of Translational Medicine 2010 8:98
  25. Little is known about the induction of humoral responses directed against human autoantigens during acute inflammation. We utilized a highly sensitive antibody profiling technology to study autoantibodies in p...

    Authors: Peter D Burbelo, Nitin Seam, Sandra Groot, Kathryn H Ching, Brian L Han, G Umberto Meduri, Michael J Iadarola and Anthony F Suffredini
    Citation: Journal of Translational Medicine 2010 8:97
  26. Bone-destructive disease treatments include bisphosphonates and antibodies against the osteoclast differentiator, RANKL (aRANKL); however, osteonecrosis of the jaw (ONJ) is a frequent side-effect. Current mode...

    Authors: Falk Wehrhan, Peter Hyckel, Jutta Ries, Phillip Stockmann, Emeka Nkenke, Karl A Schlegel, Friedrich W Neukam and Kerstin Amann
    Citation: Journal of Translational Medicine 2010 8:96
  27. Oct4 and Sox2 are two major transcription factors related to the stem cell self-renewal and differentiation. The aim of this study was to examine the association between Oct4 and Sox2 expression levels with bo...

    Authors: Nan Ge, Huan-Xin Lin, Xiang-Sheng Xiao, Ling Guo, Hui-Min Xu, Xin Wang, Ting Jin, Xiu-Yu Cai, Yi Liang, Wei-Han Hu and Tiebang Kang
    Citation: Journal of Translational Medicine 2010 8:94
  28. The aim of this study was to investigate the possibility that a decreased mitochondrial ATP synthesis causes muscular and mental fatigue and plays a role in the pathophysiology of the chronic fatigue syndrome ...

    Authors: Ruud CW Vermeulen, Ruud M Kurk, Frans C Visser, Wim Sluiter and Hans R Scholte
    Citation: Journal of Translational Medicine 2010 8:93
  29. S110 is a novel dinucleoside analog that could have advantages over existing DNA methyltransferase (DNMT) inhibitors such as decitabine. A potential therapeutic role for S110 is to increase fetal hemoglobin (H...

    Authors: Donald Lavelle, Yogen Saunthararajah, Kestis Vaitkus, Mahipal Singh, Virryan Banzon, Pasit Phiasivongsva, Sanjeev Redkar, Sarath Kanekal, David Bearss, Chongtie Shi, Roger Inloes and Joseph DeSimone
    Citation: Journal of Translational Medicine 2010 8:92
  30. Esophageal squamous cell carcinomas (ESCC) are usually asymptomatic and go undetected until they are incurable. Cytological screening is one strategy to detect ESCC at an early stage and has shown promise in p...

    Authors: Sumana Mukherjee, Mark J Roth, Sanford M Dawsey, Wusheng Yan, Jaime Rodriguez-Canales, Heidi S Erickson, Nan Hu, Alisa M Goldstein, Philip R Taylor, Annely M Richardson, Michael A Tangrea, Rodrigo F Chuaqui and Michael R Emmert-Buck
    Citation: Journal of Translational Medicine 2010 8:91
  31. Antigen-loaded dendritic cells (DC) are capable of priming naïve T cells and therefore represent an attractive adjuvant for vaccine development in anti-tumor immunotherapy. Numerous protocols have been describ...

    Authors: Maja Bürdek, Stefani Spranger, Susanne Wilde, Bernhard Frankenberger, Dolores J Schendel and Christiane Geiger
    Citation: Journal of Translational Medicine 2010 8:90
  32. Several single center studies have provided evidence of immune activation and antitumor activity of therapeutic vaccination with dendritic cells (DC) in patients with metastatic melanoma. The efficacy of this ...

    Authors: Antoni Ribas, Luis H Camacho, Sun Min Lee, Evan M Hersh, Charles K Brown, Jon M Richards, Maria Jovie Rodriguez, Victor G Prieto, John A Glaspy, Denise K Oseguera, Jackie Hernandez, Arturo Villanueva, Bartosz Chmielowski, Peggie Mitsky, Nadège Bercovici, Ernesto Wasserman…
    Citation: Journal of Translational Medicine 2010 8:89
  33. We investigated whether early combined autologous adipose-derived mesenchymal stem cell (ADMSC) and sildenafil therapy offers an additive benefit in preserving heart function in rat dilated cardiomyopathy (DCM).

    Authors: Yu-Chun Lin, Steve Leu, Cheuk-Kwan Sun, Chia-Hung Yen, Ying-Hsien Kao, Li-Teh Chang, Tzu-Hsien Tsai, Sarah Chua, Morgan Fu, Sheung-Fat Ko, Chiung-Jen Wu, Fan-Yen Lee and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2010 8:88
  34. Genome-wide gene expression profiling of whole blood is an attractive method for discovery of biomarkers due to its non-invasiveness, simple clinical site processing and rich biological content. Except for a f...

    Authors: Mark L Parrish, Chris Wright, Yarek Rivers, David Argilla, Heather Collins, Brendan Leeson, Andrey Loboda, Michael Nebozhyn, Matthew J Marton and Serguei Lejnine
    Citation: Journal of Translational Medicine 2010 8:87
  35. Changes in DNA methylation of crucial cancer genes including tumor suppressors can occur early in carcinogenesis, being potentially important early indicators of cancer. The objective of this study was to exam...

    Authors: Mónica Castro, Laura Grau, Patricia Puerta, Liliana Gimenez, Julio Venditti, Silvia Quadrelli and Marta Sánchez-Carbayo
    Citation: Journal of Translational Medicine 2010 8:86
  36. Helicobacter pylori (H. pylori) infection is associated with chronic gastritis, peptic ulceration and gastric carcinoma. Protease-activated receptor-2 (PAR-2), which is activated by trypsin, induced the activatio...

    Authors: Joo Weon Lim and Hyeyoung Kim
    Citation: Journal of Translational Medicine 2010 8:85
  37. The tumor associated antigen (TAA) gp100 was one of the first identified and has been used in clinical trials to treat melanoma patients. However, the gp100 epitope peptide restricted to HLA-A*2402 has not bee...

    Authors: Toshiyuki Baba, Marimo Sato-Matsushita, Akira Kanamoto, Akihiko Itoh, Naoki Oyaizu, Yusuke Inoue, Yutaka Kawakami and Hideaki Tahara
    Citation: Journal of Translational Medicine 2010 8:84
  38. Accurate histopathological evaluation of resected lymph nodes (LN) is essential for the reliable staging of colorectal carcinomas (CRC). With conventional sectioning and staining techniques usually only parts ...

    Authors: Roland S Croner, Vera Schellerer, Helene Demund, Claus Schildberg, Thomas Papadopulos, Elisabeth Naschberger, Michael Stürzl, Klaus E Matzel, Werner Hohenberger and Anne Schlabrakowski
    Citation: Journal of Translational Medicine 2010 8:83
  39. Authors: Britta Wahren, Priscilla Biswas, Marie Borggren, Adam Coleman, Kelly Da Costa, Winni De Haes, Tessa Dieltjens, Stefania Dispinseri, Katrijn Grupping, David Hallengärd, Julia Hornig, Katja Klein, Lara Mainetti, Paolo Palma, Marc Reudelsterz, Janna Seifried…
    Citation: Journal of Translational Medicine 2010 8:82

    The original article was published in Journal of Translational Medicine 2010 8:72

  40. The oncogene CDC25B phosphatase plays an important role in cancer cell growth. We have recently reported that patients with esophageal squamous cell carcinoma (ESCC) have significantly higher serum levels of C...

    Authors: Jun Dong, Bo-hang Zeng, Li-hua Xu, Jun-ye Wang, Man-Zhi Li, Mu-sheng Zeng and Wan-li Liu
    Citation: Journal of Translational Medicine 2010 8:81
  41. Colorectal cancer is often a deadly disease and cannot be cured at metastatic stage. Oncolytic adenoviruses have been considered as a new therapeutic option for treatment of refractory disseminated cancers, in...

    Authors: Sergio Lavilla-Alonso, Gerd Bauerschmitz, Usama Abo-Ramadan, Juha Halavaara, Sophie Escutenaire, Iulia Diaconu, Turgut Tatlisumak, Anna Kanerva, Akseli Hemminki and Sari Pesonen
    Citation: Journal of Translational Medicine 2010 8:80
  42. Melanoma vaccines have not been optimized. Adjuvants are added to activate dendritic cells (DCs) and to induce a favourable immunologic milieu, however, little is known about their cellular and molecular effec...

    Authors: Jochen T Schaefer, James W Patterson, Donna H Deacon, Mark E Smolkin, Gina R Petroni, Emily M Jackson and Craig L Slingluff Jr
    Citation: Journal of Translational Medicine 2010 8:79
  43. We recently demonstrated that increased expression of the RNA-binding protein RBM3 is associated with a favourable prognosis in breast cancer. The aim of this study was to examine the prognostic value of RBM3 ...

    Authors: Åsa Ehlén, Donal J Brennan, Björn Nodin, Darran P O'Connor, Jakob Eberhard, Maria Alvarado-Kristensson, Ian B Jeffrey, Jonas Manjer, Jenny Brändstedt, Mathias Uhlén, Fredrik Pontén and Karin Jirström
    Citation: Journal of Translational Medicine 2010 8:78
  44. The relationship between functional improvements in ischemic rats given a neural stem cell (NSC) transplant and the modulation of the class I major histocompatibility complex (MHC) mediated by NSC-derived neur...

    Authors: Chongran Sun, Han Zhang, Jin Li, Hua Huang, Hongbin Cheng, Yajie Wang, Ping Li and Yihua An
    Citation: Journal of Translational Medicine 2010 8:77

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