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Low serum mannose-binding lectin are associated with inflammation, new-onset diabetes mellitus and subclinical rejection after renal transplantation
Journal of Translational Medicine volume 9, Article number: P30 (2011)
Infections, new onset diabetes mellitus (NODAT) and rejection are frequent complications after renal transplantation and may be related to innate immunity alterations. We evaluate the relationship between serum mannose-binding lectin (MBL) levels, chronic inflammation, infection, NODAT and subclinical rejection after renal transplantation.
Patients and methods
Between March 2005 and October 2006 consecutive non-diabetic renal transplant recipients were recruited. Serum levels of MBL, soluble tumor necrosis factor receptor 2 (sTNFR2) and neutrophil gelatinase associated lipocalin (NGAL) were determined before transplant and at 1 and 3 months. An oral glucose tolerance test was performed at 3 months. A surveillance 3-month renal biopsy was performed in a subset of 60 patients with stable renal function.
A total of 125 patients were recruited and 111 had a functioning graft at 3 months. MBL serum levels remained unchanged following transplantation. Subjects with low MBL (lower tertile) had higher pretransplant sTNFR2 (40 ± 13 vs. 35 ± 11 ng/ml, p=0.05) and NGAL (638 ± 114 vs. 553 ± 185 ng/ml, p=0.03), an increased incidence of bacterial/fungal infection (p=0.021) and an increased prevalence of NODAT at 3 months (44.4 vs 22.6%, p=0.01). Multivariate analysis confirmed that MBL was a risk factor for NODAT (relative risk: 3.04, 95% confidence interval: 1.18-7.81; p=0.021) adjusting for age, pre-transplant impaired fasting glucose and body mass index. Subclinical rejection in the 3-month surveillance biopsy was observed in 7 of 18 (38.9%) low MBL patients and in 3 of 42 (7.1%) high MBL patients (p=0.005). Induction and maintenance immunosuppression was not different in patients with low and high MBL levels.
Low MBL serum levels in renal transplants are associated with major outcome variable after renal transplantation such as bacterial/fungal infections, NODAT and subclinical rejection. These results suggest that alterations of the innate immunity may play an important role in renal transplantation.
This work was supported by a Fondo Investigaciones Sanitarias (PI040086) and a Sociedad Española Nefrología 2004 grants. Meritxell Ibernon was supported by a Fundació Catalana Trasplantament grant.
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Moreso, F., Ibernon, M., Fernández-Real, J.M. et al. Low serum mannose-binding lectin are associated with inflammation, new-onset diabetes mellitus and subclinical rejection after renal transplantation. J Transl Med 9, P30 (2011). https://doi.org/10.1186/1479-5876-9-S2-P30
- Renal Transplantation
- Neutrophil Gelatinase Associate Lipocalin
- Soluble Tumor Necrosis Factor Receptor
- Stable Renal Function
- Onset Diabetes Mellitus