Systems medicine in chronic diseases: COPD as a use case

Brief introduction to Synergy-COPD

Authors: Adina Ratoi

Synergy-COPD: a systems approach for understanding and managing chronic diseases

Chronic diseases (CD) are generating a dramatic societal burden worldwide that is expected to persist over the next decades. The challenges posed by the epidemics of CD have triggered a novel health paradigm w...

Authors: David Gomez-Cabrero, Magi Lluch-Ariet, Jesper Tegnér, Marta Cascante, Felip Miralles and Josep Roca

Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management

Heterogeneity in clinical manifestations and disease progression in Chronic Obstructive Pulmonary Disease (COPD) lead to consequences for patient health risk assessment, stratification and management. Implicit...

Authors: Josep Roca, Claudia Vargas, Isaac Cano, Vitaly Selivanov, Esther Barreiro, Dieter Maier, Francesco Falciani, Peter Wagner, Marta Cascante, Judith Garcia-Aymerich, Susana Kalko, Igor Marin De Mas, Jesper Tegnér, Joan Escarrabill, Alvar Agustí and David Gomez-Cabrero

Systems Medicine: from molecular features and models to the clinic in COPD

Chronic Obstructive Pulmonary Disease (COPD) patients are characterized by heterogeneous clinical manifestations and patterns of disease progression. Two major factors that can be used to identify COPD subtypes a...

Authors: David Gomez-Cabrero, Jörg Menche, Isaac Cano, Imad Abugessaisa, Mercedes Huertas-Migueláñez, Akos Tenyi, Igor Marin de Mas, Narsis A Kiani, Francesco Marabita, Francesco Falciani, Kelly Burrowes, Dieter Maier, Peter Wagner, Vitaly Selivanov, Marta Cascante, Josep Roca…

Computational modeling of the obstructive lung diseases asthma and COPD

Asthma and chronic obstructive pulmonary disease (COPD) are characterized by airway obstruction and airflow limitation and pose a huge burden to society. These obstructive lung diseases impact the lung physiol...

Authors: Kelly Suzanne Burrowes, Tom Doel and Chris Brightling

The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research

Previously we generated a chronic obstructive pulmonary disease (COPD) specific knowledge base (http://​www.​copdknowledgebas​e.​eu) from clinical and expe...

Authors: Isaac Cano, Ákos Tényi, Christine Schueller, Martin Wolff, M Mercedes Huertas Migueláñez, David Gomez-Cabrero, Philipp Antczak, Josep Roca, Marta Cascante, Francesco Falciani and Dieter Maier

Simulation environment and graphical visualization environment: a COPD use-case

Today, many different tools are developed to execute and visualize physiological models that represent the human physiology. Most of these tools run models written in very specific programming languages which ...

Authors: Mercedes Huertas-Migueláñez, Daniel Mora, Isaac Cano, Dieter Maier, David Gomez-Cabrero, Magí Lluch-Ariet and Felip Miralles

Knowledge sharing in the health scenario

The understanding of certain data often requires the collection of similar data from different places to be analysed and interpreted. Interoperability standards and ontologies, are facilitating data interchang...

Authors: Magí Lluch-Ariet, Albert Brugués de la Torre, Francesc Vallverdú and Josep Pegueroles-Vallés

Clinical Decision Support Systems (CDSS) for preventive management of COPD patients

The use of information and communication technologies to manage chronic diseases allows the application of integrated care pathways, and the optimization and standardization of care processes. Decision support...

Authors: Filip Velickovski, Luigi Ceccaroni, Josep Roca, Felip Burgos, Juan B Galdiz, Nuria Marina and Magí Lluch-Ariet

Workforce preparation: the Biohealth computing model for Master and PhD students

The article addresses the strategic role of workforce preparation in the process of adoption of Systems Medicine as a driver of biomedical research in the new health paradigm. It reports on relevant initiative...

Authors: Marta Cascante, Pedro de Atauri, David Gomez-Cabrero, Peter Wagner, Josep Joan Centelles, Silvia Marin, Isaac Cano, Filip Velickovski, Igor Marin de Mas, Dieter Maier, Josep Roca and Philippe Sabatier

Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD project

Chronic Obstructive Pulmonary Disease (COPD) is a major challenge for healthcare. Heterogeneities in clinical manifestations and in disease progression are relevant traits in COPD with impact on patient manage...

Authors: Felip Miralles, David Gomez-Cabrero, Magí Lluch-Ariet, Jesper Tegnér, Marta Cascante and Josep Roca

Biomedical research in a Digital Health Framework

This article describes a Digital Health Framework (DHF), benefitting from the lessons learnt during the three-year life span of the FP7 Synergy-COPD project. The DHF aims to embrace the emerging requirements -...

Authors: Isaac Cano, Magí Lluch-Ariet, David Gomez-Cabrero, Dieter Maier, Susana Kalko, Marta Cascante, Jesper Tegnér, Felip Miralles, Diego Herrera and Josep Roca