Jin K, Li T, van Dam H, Zhou F, Zhang L. Molecular insights into tumour metastasis: tracing the dominant events. J Pathol. 2017;241:567–77.
Article
CAS
PubMed
Google Scholar
Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007;449:557–63.
Article
CAS
PubMed
Google Scholar
Cotanche DA, Sepulveda R, Rogers RA. Effect of pericytes on melanoma development. J Clin Oncol. 2012;30:83.
Google Scholar
Dou YN, Chaudary N, Chang MC, Dunne M, Huang H, Jaffray DA, et al. Tumor microenvironment determines response to a heat-activated thermosensitive liposome formulation of cisplatin in cervical carcinoma. J Control Release. 2017;262:182–91.
Article
CAS
PubMed
Google Scholar
Yan XL, Jia YL, Chen L, Zeng Q, Zhou JN, Fu CJ, et al. Hepatocellular carcinoma-associated mesenchymal stem cells promote hepatocarcinoma progression: role of the S100A4-miR155-SOCS1-MMP9 axis. Hepatology. 2013;57:2274–86.
Article
CAS
PubMed
Google Scholar
Shi Y, Du L, Lin L, Wang Y. Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets. Nat Rev Drug Discov. 2017;16:35–52.
Article
CAS
PubMed
Google Scholar
Fan W, Li J, Wang Y, Pan J, Li S, Zhu L, et al. CD105 promotes chondrogenesis of synovium-derived mesenchymal stem cells through Smad2 signaling. Biochem Biophys Res Commun. 2016;474:338–44.
Article
CAS
PubMed
Google Scholar
Ridge SM, Sullivan FJ, Glynn SA. Mesenchymal stem cells: key players in cancer progression. Mol Cancer. 2017;16:31.
Article
PubMed
PubMed Central
Google Scholar
Chaturvedi P, Gilkes DM, Wong CC, Luo W, Zhang H, Wei H, et al. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest. 2013;123:189–205.
Article
CAS
PubMed
Google Scholar
Luo J, Ok LS, Liang L, Huang CK, Li L, Wen S, et al. Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling. Oncogene. 2014;33:2768–78.
Article
CAS
PubMed
Google Scholar
Xu WT, Bian ZY, Fan QM, Li G, Tang TT. Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis. Cancer Lett. 2009;281:32–41.
Article
CAS
PubMed
Google Scholar
Meleshina AV, Cherkasova EI, Shirmanova MV, Klementieva NV, Kiseleva EV, Snopova LB, et al. Influence of mesenchymal stem cells on metastasis development in mice in vivo. Stem Cell Res Ther. 2015;6:15.
Article
PubMed
PubMed Central
Google Scholar
Li GC, Ye QH, Dong QZ, Ren N, Jia HL, Qin LX. Mesenchymal stem cells seldomly fuse with hepatocellular carcinoma cells and are mainly distributed in the tumor stroma in mouse models. Oncol Rep. 2013;29:713–9.
Article
CAS
PubMed
Google Scholar
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8:336–41.
Article
PubMed
Google Scholar
Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14:43.
Article
PubMed
PubMed Central
Google Scholar
Zhang Y, Yang P, Sun T, Li D, Xu X, Rui Y, et al. miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol. 2013;15:284–94.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang XH, Jin X, Malladi S, Zou Y, Wen YH, Brogi E, et al. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell. 2013;154:1060–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Goldstein RH, Reagan MR, Anderson K, Kaplan DL, Rosenblatt M. Human bone marrow-derived MSCs can home to orthotopic breast cancer tumors and promote bone metastasis. Cancer Res. 2010;70:10044–50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang P, Dong L, Yan K, Long H, Yang TT, Dong MQ, et al. CXCR4-mediated osteosarcoma growth and pulmonary metastasis is promoted by mesenchymal stem cells through VEGF. Oncol Rep. 2013;30:1753–61.
Article
CAS
PubMed
Google Scholar
Souza LE, Almeida DC, Yaochite JN, Covas DT, Fontes AM. Intravenous administration of bone marrow-derived multipotent mesenchymal stromal cells enhances the recruitment of CD11b(+) myeloid cells to the lungs and facilitates B16-F10 melanoma colonization. Exp Cell Res. 2016;345:141–9.
Article
CAS
PubMed
Google Scholar
Shangguan L, Ti X, Krause U, Hai B, Zhao Y, Yang Z, et al. Inhibition of TGF-beta/Smad signaling by BAMBI blocks differentiation of human mesenchymal stem cells to carcinoma-associated fibroblasts and abolishes their protumor effects. Stem Cells. 2012;30:2810–9.
Article
PubMed
Google Scholar
Mi Z, Bhattacharya SD, Kim VM, Guo H, Talbot LJ, Kuo PC. Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis. Carcinogenesis. 2011;32:477–87.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273:408–12.
Article
CAS
PubMed
Google Scholar
Hooijmans CR, Geessink FJ, Ritskes-Hoitinga M, Scheffer GJ. A systematic review and meta-analysis of the ability of analgesic drugs to reduce metastasis in experimental cancer models. Pain. 2015;156:1835–44.
Article
PubMed
PubMed Central
Google Scholar
Vu Q, Xie K, Eckert M, Zhao W, Cramer SC. Meta-analysis of preclinical studies of mesenchymal stromal cells for ischemic stroke. Neurology. 2014;82:1277–86.
Article
PubMed
PubMed Central
Google Scholar
McIntyre LA, Moher D, Fergusson DA, Sullivan KJ, Mei SH, Lalu M, et al. Efficacy of mesenchymal stromal cell therapy for acute lung injury in preclinical animal models: a systematic review. PLoS ONE. 2016;11:e147170.
Google Scholar
Chen Y, Ling L, Su G, Han M, Fan X, Xun P, et al. Effect of intermittent versus chronic calorie restriction on tumor incidence: a systematic review and meta-analysis of animal studies. Sci Rep. 2016;6:33739.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lv M, Zhu X, Wang H, Wang F, Guan W. Roles of caloric restriction, ketogenic diet and intermittent fasting during initiation, progression and metastasis of cancer in animal models: a systematic review and meta-analysis. PLoS ONE. 2014;9:e115147.
Article
PubMed
PubMed Central
Google Scholar
Hooijmans CR, Geessink FJ, Ritskes-Hoitinga M, Scheffer GJ. A systematic review of the modifying effect of anaesthetic drugs on metastasis in animal models for cancer. PLoS ONE. 2016;11:e156152.
Article
Google Scholar
Rolandsson ES, Andersson SA, Skog I, Hansson L, Larsson H, Le Blanc K, et al. MSC from fetal and adult lungs possess lung-specific properties compared to bone marrow-derived MSC. Sci Rep. 2016;6:29160.
Article
Google Scholar
Lin HR, Heish CW, Liu CH, Muduli S, Li HF, Higuchi A, et al. Purification and differentiation of human adipose-derived stem cells by membrane filtration and membrane migration methods. Sci Rep. 2017;7:40069.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gonzalez ME, Martin EE, Anwar T, Arellano-Garcia C, Medhora N, Lama A, et al. Mesenchymal stem cell-induced DDR2 mediates stromal-breast cancer interactions and metastasis growth. Cell Rep. 2017;18:1215–28.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ljujic B, Milovanovic M, Volarevic V, Murray B, Bugarski D, Przyborski S, et al. Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice. Sci Rep. 2013;3:2298.
Article
PubMed
PubMed Central
Google Scholar
Lacerda L, Debeb BG, Smith D, Larson R, Solley T, Xu W, et al. Mesenchymal stem cells mediate the clinical phenotype of inflammatory breast cancer in a preclinical model. Breast Cancer Res. 2015;17:42.
Article
PubMed
PubMed Central
Google Scholar
Albarenque SM, Zwacka RM, Mohr A. Both human and mouse mesenchymal stem cells promote breast cancer metastasis. Stem Cell Res. 2011;7:163–71.
Article
CAS
PubMed
Google Scholar
Sun B, Roh KH, Park JR, Lee SR, Park SB, Jung JW, et al. Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model. Cytotherapy. 2009;11(289–298):1–298.
Google Scholar
Ma F, Chen D, Chen F, Chi Y, Han Z, Feng X, et al. Human umbilical cord mesenchymal stem cells promote breast cancer metastasis by interleukin-8- and interleukin-6-dependent induction of CD44(+)/CD24(−) cells. Cell Transplant. 2015;24:2585–99.
Article
PubMed
Google Scholar
Kamat P, Schweizer R, Kaenel P, Salemi S, Calcagni M, Giovanoli P, et al. Human adipose-derived mesenchymal stromal cells may promote breast cancer progression and metastatic spread. Plast Reconstr Surg. 2015;136:76–84.
Article
CAS
PubMed
Google Scholar
Szebeni GJ, Kriston-Pal E, Blazso P, Katona RL, Novak J, Szabo E, et al. Identification of galectin-1 as a critical factor in function of mouse mesenchymal stromal cell-mediated tumor promotion. PLoS ONE. 2012;7:e41372.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ke CC, Liu RS, Suetsugu A, Kimura H, Ho JH, Lee OK, et al. In vivo fluorescence imaging reveals the promotion of mammary tumorigenesis by mesenchymal stromal cells. PLoS ONE. 2013;8:e69658.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tsukamoto S, Honoki K, Fujii H, Tohma Y, Kido A, Mori T, et al. Mesenchymal stem cells promote tumor engraftment and metastatic colonization in rat osteosarcoma model. Int J Oncol. 2012;40:163–9.
CAS
PubMed
Google Scholar
Zhang P, Dong L, Long H, Yang TT, Zhou Y, Fan QY, et al. Homologous mesenchymal stem cells promote the emergence and growth of pulmonary metastases of the rat osteosarcoma cell line UMR-106. Oncol Lett. 2014;8:127–32.
Article
PubMed
PubMed Central
Google Scholar
Avril P, Le Nail LR, Brennan MA, Rosset P, De Pinieux G, Layrolle P, et al. Mesenchymal stem cells increase proliferation but do not change quiescent state of osteosarcoma cells: potential implications according to the tumor resection status. J Bone Oncol. 2016;5:5–14.
Article
PubMed
Google Scholar
Li GC, Ye QH, Xue YH, Sun HJ, Zhou HJ, Ren N, et al. Human mesenchymal stem cells inhibit metastasis of a hepatocellular carcinoma model using the MHCC97-H cell line. Cancer Sci. 2010;101:2546–53.
Article
CAS
PubMed
Google Scholar
Lin JT, Wang JY, Chen MK, Chen HC, Chang TH, Su BW, et al. Colon cancer mesenchymal stem cells modulate the tumorigenicity of colon cancer through interleukin 6. Exp Cell Res. 2013;319:2216–29.
Article
CAS
PubMed
Google Scholar
Shinagawa K, Kitadai Y, Tanaka M, Sumida T, Onoyama M, Ohnishi M, et al. Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer. Int J Cancer. 2013;132:813–23.
Article
CAS
PubMed
Google Scholar
Shinagawa K, Kitadai Y, Tanaka M, Sumida T, Kodama M, Higashi Y, et al. Mesenchymal stem cells enhance growth and metastasis of colon cancer. Int J Cancer. 2010;127:2323–33.
Article
CAS
PubMed
Google Scholar
Akay I, Oxmann D, Helfenstein A, Mentlein R, Schunke M, Hassenpflug J, et al. Tumor risk by tissue engineering: cartilaginous differentiation of mesenchymal stem cells reduces tumor growth. Osteoarthritis Cartilage. 2010;18:389–96.
Article
CAS
PubMed
Google Scholar
Zhang L, Su XS, Ye JS, Wang YY, Guan Z, Yin YF. Bone marrow mesenchymal stem cells suppress metastatic tumor development in mouse by modulating immune system. Stem Cell Res Ther. 2015;6:45.
Article
PubMed
PubMed Central
Google Scholar
Yang X, Li Z, Ma Y, Gao J, Liu S, Gao Y, et al. Human umbilical cord mesenchymal stem cells promote carcinoma growth and lymph node metastasis when co-injected with esophageal carcinoma cells in nude mice. Cancer Cell Int. 2014;14:93.
Article
PubMed
PubMed Central
Google Scholar
Hayes-Jordan A, Wang YX, Walker P, Cox CS. Mesenchymal stromal cell dependent regression of pulmonary metastasis from Ewing’s. Front Pediatr. 2014;2:44.
Article
PubMed
PubMed Central
Google Scholar
Xue Z, Wu X, Chen X, Liu Y, Wang X, Wu K, et al. Mesenchymal stem cells promote epithelial to mesenchymal transition and metastasis in gastric cancer though paracrine cues and close physical contact. J Cell Biochem. 2015;116:618–27.
Article
CAS
PubMed
Google Scholar
Kitayama J, Emoto S, Yamaguchi H, Ishigami H, Watanabe T. CD90+ mesothelial-like cells in peritoneal fluid promote peritoneal metastasis by forming a tumor permissive microenvironment. PLoS ONE. 2014;9:e86516.
Article
PubMed
PubMed Central
Google Scholar
Wang ML, Pan CM, Chiou SH, Chen WH, Chang HY, Lee OK, et al. Oncostatin m modulates the mesenchymal-epithelial transition of lung adenocarcinoma cells by a mesenchymal stem cell-mediated paracrine effect. Cancer Res. 2012;72:6051–64.
Article
CAS
PubMed
Google Scholar
Carnet O, Lecomte J, Masset A, Primac I, Durre T, Maertens L, et al. Mesenchymal stem cells shed amphiregulin at the surface of lung carcinoma cells in a juxtacrine manner. Neoplasia. 2015;17:552–63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Keramidas M, de Fraipont F, Karageorgis A, Moisan A, Persoons V, Richard MJ, et al. The dual effect of mesenchymal stem cells on tumour growth and tumour angiogenesis. Stem Cell Res Ther. 2013;4:41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Waghray M, Yalamanchili M, Dziubinski M, Zeinali M, Erkkinen M, Yang H, et al. GM-CSF mediates mesenchymal-epithelial cross-talk in pancreatic cancer. Cancer Discov. 2016;6:886–99.
Article
CAS
PubMed
PubMed Central
Google Scholar
Djouad F, Bony C, Apparailly F, Louis-Plence P, Jorgensen C, Noel D. Earlier onset of syngeneic tumors in the presence of mesenchymal stem cells. Transplantation. 2006;82:1060–6.
Article
PubMed
Google Scholar