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Table 3 Effect size and subgroup analyses for MSC administration in preclinical studies of solid tumor metastasis number

From: Effects of mesenchymal stem cells on solid tumor metastasis in experimental cancer models: a systematic review and meta-analysis

Group

Weight

Effect size

I2a

P

I2b

(%)

SMD

95% CI

(%)

(%)

All experiments

100.0

1.23

0.43, 2.03

89

  

Cancer type

 Breast cancer

48.6

2.04

0.87, 3.21

90

0.060

71.8

 Other cancer

51.4

0.48

− 0.65, 1.61

89

  

Animal species/strain

 Nude mice

82.3

1.12

0.26, 1.97

89

0.690

0

 Other mice/rat

17.7

1.67

− 0.9, 4.23

92

  

Source of MSC

 Human bone marrow

40.7

1.96

0.59, 3.33

87

0.330

12.4

 Other human tissue

18.2

0.09

− 1.94, 2.13

94

  

 Mice/rat bone marrow

31.0

0.73

− 0.72, 2.17

89

  

 Unclear

10.0

2.15

− 0.14, 4.34

85

  

Metastasis estimation

 Fluorescence microscopy

42.0

1.11

− 0.3, 2.35

90

0.170

44.2

 Histological evaluation

40.1

2.02

0.76, 3.29

88

  

 Bioluminescence

17.9

− 0.54

− 2.95, 1.87

89

  

Cancer cell/MSC dose ratio

 = 1

62.6

1.11

0.1, 2.12

90

0.030

72.7

 > 1

7.2

− 0.20

− 1.08, 0.67

0

  

 < 1

30.2

1.85

0.45, 3.24

80

  

Timing of MSC administration

 Co-administration

68.5

2.18

1.38, 2.99

82

0.001

94

 Follow-administration

31.5

− 1.13

− 2.50, 0.23

88

  

Study length (days)

 ≤ 42

59.1

0.32

− 0.70, 1.35

91

0.006

86.7

 > 42

40.9

2.44

1.32, 3.56

78

  

Metastasis site

 Lung

81.6

1.80

0.28, 2.07

89

0.570

0

 Other tissue

18.4

1.66

0.26, 3.07

73

  

Study quality category

 Meet 9–12 criteria

0

–

–

–

0.07

70.5

 Meet 5–8 criteria

20.3

2.92

0.90, 4.94

90

  

 Meet 0–4 criteria

79.7

0.85

− 0.04, 1.74

89

  

Impact factor of journal

 ≤ 5

56.8

0.30

− 0.73, 1.32

89

0.004

87.7

 > 5

43.2

2.30

1.38, 3.22

74

  
  1. SMD standard mean difference; CI confidence interval; I2a, I2 for heterogeneity within each subgroup; P P value for heterogeneity between subgroups; I2b, I2 for heterogeneity between subgroups