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  1. To evaluate embryonic stem cell (ESC) harvesting methods with an emphasis on derivation of ESC lines without feeder cells or sera. Using a murine model, laser-assisted blastocyst dissection was performed and c...

    Authors: Noriko Tanaka, Takumi Takeuchi, Queenie V Neri, Eric Scott Sills and Gianpiero D Palermo

    Citation: Journal of Translational Medicine 2006 4:20

    Content type: Methodology

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  2. Enumeration of circulating peripheral blood dendritic cells (DCs) is complicated by the absence of a unique cell surface marker expressed on all DC subsets and by the use of various biological adjuvants to mod...

    Authors: Kehui Wang, Kevin P Nishimoto, Rita S Mehta and Edward L Nelson

    Citation: Journal of Translational Medicine 2006 4:18

    Content type: Methodology

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  3. Monocyte/macrophages (MO/MA), a polymorphic population of innate immune cells, have the potential to mediate antitumor effects, and may also contribute to protumor effects. A priming and post-chemotherapy sche...

    Authors: Sachin M Apte, Saroj Vadhan-Raj, Lorenzo Cohen, Roland L Bassett, Ilyssa O Gordon, Charles F Levenback, Pedro T Ramirez, Stacie T Gallardo, Rebecca S Patenia, Michael E Garcia, Revathy B Iyer and Ralph S Freedman

    Citation: Journal of Translational Medicine 2006 4:16

    Content type: Research

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  4. Innate immunity is considered the first line of host defense and microglia presumably play a critical role in mediating potent innate immune responses to traumatic and infectious challenges in the human brain....

    Authors: S Farzana Hussain, David Yang, Dima Suki, Elizabeth Grimm and Amy B Heimberger

    Citation: Journal of Translational Medicine 2006 4:15

    Content type: Research

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  5. Research has found that certain bacteria are associated with human cancers. Their role, however, is still unclear. Convincing evidence links some species to carcinogenesis while others appear promising in the ...

    Authors: DL Mager

    Citation: Journal of Translational Medicine 2006 4:14

    Content type: Review

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  6. A functional blood supply is essential for tumor growth and proliferation. However, the mechanism of blood vessel recruitment to the tumor is still poorly understood. Ideally, a thorough molecular assessment o...

    Authors: Amelia C Grover, Michael A Tangrea, Karen G Woodson, Benjamin S Wallis, Jeffrey C Hanson, Rodrigo F Chuaqui, John W Gillespie, Heidi S Erickson, Robert F Bonner, Thomas J Pohida, Michael R Emmert-Buck and Steven K Libutti

    Citation: Journal of Translational Medicine 2006 4:13

    Content type: Research

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  7. Multicellular spheroids, an appropriate in vitro system for simulating 3-D tumor micro-milieu can be used for evaluating and predicting tumor response to therapeutic agents including metabolic inhibitors. However...

    Authors: Divya Khaitan, Sudhir Chandna, MB Arya and BS Dwarakanath

    Citation: Journal of Translational Medicine 2006 4:12

    Content type: Research

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  8. Studies of gene expression profiling have been successfully used for the identification of molecules to be employed as potential prognosticators. In analogy with gene expression profiling, we have recently pro...

    Authors: Antonella Zucchetto, Paolo Sonego, Massimo Degan, Riccardo Bomben, Michele Dal Bo, Pietro Bulian, Dania Benedetti, Maurizio Rupolo, Giovanni Del Poeta, Renato Campanini and Valter Gattei

    Citation: Journal of Translational Medicine 2006 4:11

    Content type: Review

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  9. Hydralazine was one of the first orally active antihypertensive drugs developed. Currently, it is used principally to treat pregnancy-associated hypertension. Hydralazine causes two types of side effects. The ...

    Authors: Claudia Arce, Blanca Segura-Pacheco, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Myrna Candelaria and Alfonso Dueñnas-Gonzalez

    Citation: Journal of Translational Medicine 2006 4:10

    Content type: Review

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  10. Thrombopoietin (TPO), the primary cytokine regulating megakaryocyte proliferation and differentiation, exerts significant influence on other hematopoietic lineages as well, including erythroid, granulocytic an...

    Authors: John M Ninos, Leigh C Jefferies, Christopher R Cogle and William G Kerr

    Citation: Journal of Translational Medicine 2006 4:9

    Content type: Research

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  11. Malignant ascites often develops in advanced stages of ovarian carcinoma, consisting of single and aggregated tumor cells, or spheroids. Spheroids have commonly been used as tumor models to study drug efficacy...

    Authors: Kathryn M Burleson, Matthew P Boente, Stefan E Pambuccian and Amy PN Skubitz

    Citation: Journal of Translational Medicine 2006 4:6

    Content type: Research

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  12. Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. Recent evidence d...

    Authors: Leonardo Rossi, Ramy Moharram, Brian M Martin, Richard L White and Monica C Panelli

    Citation: Journal of Translational Medicine 2006 4:5

    Content type: Methodology

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  13. Nasopharyngeal carcinoma (NPC) is a highly prevalent disease in Southeast Asia and its prevalence is clearly affected by genetic background. Various theories have been suggested for its high incidence in this ...

    Authors: Xin Li, Ena Wang, Ying-dong Zhao, Jia-Qiang Ren, Ping Jin, Kai-Tai Yao and Francesco M Marincola

    Citation: Journal of Translational Medicine 2006 4:4

    Content type: Research

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  14. The dendritic cell (DC) possesses the ability to stimulate both T helper 1 (Th1) and Th2 responses depending on activation stimuli. Although it is known that chemically or genetically modified DC can be used t...

    Authors: Thomas E Ichim, Igor A Popov, Neil H Riordan, Hamid Izadi, Zaohui Zhong, Li Yijian, Salman Sher and Eugenia K Oleinik

    Citation: Journal of Translational Medicine 2006 4:2

    Content type: Research

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  15. Based on previous studies that demonstrated the safety profile and preliminary clinical activity of prostate specific antigen (PSA) targeted therapeutic vaccines, as well as recent laboratory data supporting t...

    Authors: RS DiPaola, M Plante, H Kaufman, DP Petrylak, R Israeli, E Lattime, K Manson and T Schuetz

    Citation: Journal of Translational Medicine 2006 4:1

    Content type: Research

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  16. We have recently developed a candidate HIV-1 vaccine model based on HIV-1 Pr55gag Virus-Like Particles (HIV-VLPs), produced in a baculovirus expression system and presenting a gp120 molecule from an Ugandan HI...

    Authors: Eleonora Aricò, Ena Wang, Maria Lina Tornesello, Maria Tagliamonte, George K Lewis, Francesco M Marincola, Franco M Buonaguro and Luigi Buonaguro

    Citation: Journal of Translational Medicine 2005 3:45

    Content type: Research

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  17. The goal of this study was to evaluate changes in gene expression in SW-620 cells in response to SN-38 in order to further elucidate the mechanisms by which SN-38 causes apoptosis and cell cycle arrest.

    Authors: Vinicius Souza, Yan Bin Dong, H Sam Zhou, Wolfgang Zacharias and Kelly M McMasters

    Citation: Journal of Translational Medicine 2005 3:44

    Content type: Research

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  18. Antiphospholipid syndrome (APS) has been often associated to RPL since 1980 and some reports in the Literature rarely described antibodies to factor XII in patients with APS.

    Authors: Maristella D'Uva, Ida Strina, Antonio Mollo, Antonio Ranieri, Giuseppe De Placido and Pierpaolo Di Micco

    Citation: Journal of Translational Medicine 2005 3:43

    Content type: Methodology

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  19. The tetraspan protein CD63, originally described as a stage-specific melanoma antigen but also present in a number of normal cells, regulates melanoma cell growth in nude mice, motility in serum containing med...

    Authors: Joji Iida, Amy PN Skubitz, James B McCarthy and Keith M Skubitz

    Citation: Journal of Translational Medicine 2005 3:42

    Content type: Research

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  20. A CD8+ cytotoxic T lymphocyte (CTL) line was derived from the peripheral blood mononuclear cells of a patient with primary melanoma. The CD8+ CTL line specifically lysed the autologous primary melanoma cells and ...

    Authors: Rajasekharan Somasundaram, Laura Caputo, DuPont Guerry and Dorothee Herlyn

    Citation: Journal of Translational Medicine 2005 3:41

    Content type: Research

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  21. A sizeable number of HIV-infected patients receiving HAART do not maintain prolonged virologic suppression. We evaluated long-term HIV viral load (VL) responses to HAART as a risk factor for AIDS events (AE) t...

    Authors: Powel Kazanjian, Wei Wei, Morton Brown, Tejal Gandhi and Kamal Amin

    Citation: Journal of Translational Medicine 2005 3:40

    Content type: Research

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  22. Targeted inhibition of protein kinases is now acknowledged as an effective approach for cancer therapy. However, targeted therapies probably have limited success because cancer cells have alternate pathways fo...

    Authors: Kerrington R Molhoek, David L Brautigan and Craig L Slingluff Jr

    Citation: Journal of Translational Medicine 2005 3:39

    Content type: Research

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  23. The epidermal growth factor receptor (EGFR) is over expressed in approximately 50–60% of glioblastoma (GBM) tumors, and the most common EGFR mutant, EGFRvIII, is expressed in 24–67% of cases. This study was de...

    Authors: Amy B Heimberger, Dima Suki, David Yang, Weiming Shi and Kenneth Aldape

    Citation: Journal of Translational Medicine 2005 3:38

    Content type: Research

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  24. IL-1β is a pleotropic cytokine that may mediate increased procoagulant activity and permeability in endothelial tissue during inflammatory conditions. The procoagulant effects of IL-1β are mediated through ind...

    Authors: Markus Puhlmann, David M Weinreich, Jeffrey M Farma, Nancy M Carroll, Ewa M Turner and H Richard Alexander Jr

    Citation: Journal of Translational Medicine 2005 3:37

    Content type: Research

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  25. Myeloid-related protein 8 (MRP8) and MRP14 are S100 family calcium binding proteins that form a heterodimer known as calprotectin or MRP8/14 that is present in the cytosol of neutrophils and monocytes. MRP8/14...

    Authors: David F Stroncek, Raji A Shankar and Keith M Skubitz

    Citation: Journal of Translational Medicine 2005 3:36

    Content type: Research

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  26. Ovarian cancer represents the fifth leading cause of death from all cancers for women. During the last decades overall survival has improved due to the use of new chemotherapy schedules. Still, the majority of...

    Authors: HW Nijman, A Lambeck, SH van der Burg, AGJ van der Zee and T Daemen

    Citation: Journal of Translational Medicine 2005 3:34

    Content type: Review

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  27. New developments in science are rapidly influencing and shaping basic and clinical research and medicine. This has led to the emergence of multiple opportunities and challenges on many levels in the bio-medica...

    Authors: Kai-Christian Sonntag

    Citation: Journal of Translational Medicine 2005 3:33

    Content type: Commentary

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  28. Our goal was to identify gene signatures predictive of response to preoperative systemic chemotherapy (PST) with epirubicin/cyclophosphamide (EC) in patients with primary breast cancer.

    Authors: Olga Modlich, Hans-Bernd Prisack, Marc Munnes, Werner Audretsch and Hans Bojar

    Citation: Journal of Translational Medicine 2005 3:32

    Content type: Research

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  29. Over the past three decades, there have been remarkable advances in the treatment of bone and soft tissue sarcomas. These include the introduction of adjuvant chemotherapy, establishment of guidelines for adeq...

    Authors: Satoshi Kawaguchi, Takuro Wada, Tomohide Tsukahara, Kazunori Ida, Toshihiko Torigoe, Noriyuki Sato and Toshihiko Yamashita

    Citation: Journal of Translational Medicine 2005 3:31

    Content type: Review

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  30. Previous studies have shown that in platelets of mild Alzheimer Disease (AD) patients there are alterations of specific APP forms, paralleled by alteration in expression level of both ADAM 10 and BACE when com...

    Authors: Monica Di Luca, Enzo Grossi, Barbara Borroni, Martina Zimmermann, Elena Marcello, Francesca Colciaghi, Fabrizio Gardoni, Marco Intraligi, Alessandro Padovani and Massimo Buscema

    Citation: Journal of Translational Medicine 2005 3:30

    Content type: Research

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  31. We present a generic dendritic cell (DC) vaccine strategy for patients with renal cell carcinoma (RCC) based on the use of RNA as a source of multiplex tumor-associated antigens (TAAs). Instead of preparing RN...

    Authors: Christiane Geiger, Sybille Regn, Andreas Weinzierl, Elfriede Noessner and Dolores J Schendel

    Citation: Journal of Translational Medicine 2005 3:29

    Content type: Research

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  32. The study of clinical samples is often limited by the amount of material available to study. While proteins cannot be multiplied in their natural form, DNA and RNA can be amplified from small specimens and use...

    Authors: Ena Wang

    Citation: Journal of Translational Medicine 2005 3:28

    Content type: Review

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  33. The purpose of the present investigation was to determine if the salivary counts of 40 common oral bacteria in subjects with an oral squamous cell carcinoma (OSCC) lesion would differ from those found in cance...

    Authors: DL Mager, AD Haffajee, PM Devlin, CM Norris, MR Posner and JM Goodson

    Citation: Journal of Translational Medicine 2005 3:27

    Content type: Research

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  34. Nasopharyngeal carcinoma (NPC) is a tumor derived from epithelial cells and Epstein-Barr virus infection has been reported to be a cause of this disease. Chemokine receptor CXCR4 was found to be involved in HI...

    Authors: Na Wang, Qiu-Liang Wu, Yan Fang, Hai-Qiang Mai, Mu-Sheng Zeng, Guo-Ping Shen, Jing-Hui Hou and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2005 3:26

    Content type: Research

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  35. Epithelial ovarian cancer (EOC) represents the most frequent cause of death in the United States from a cancer involving the female genital tract. Contributing to the overall poor outcome in EOC patients, are ...

    Authors: Xipeng Wang, Ena Wang, John J Kavanagh and Ralph S Freedman

    Citation: Journal of Translational Medicine 2005 3:25

    Content type: Review

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  36. Interferon (IFN)-α is considered a key modulator of immunopathological processes through a signature-specific activation of mononuclear phagocytes (MPs). This study utilized global transcript analysis to chara...

    Authors: David F Stroncek, Christopher Basil, Dirk Nagorsen, Sara Deola, Eleonora Aricó, Kina Smith, Ena Wang, Francesco M Marincola and Monica C Panelli

    Citation: Journal of Translational Medicine 2005 3:24

    Content type: Research

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  37. The continuous efforts aimed at the identification of new immune epitopes across the MHC system has led to the discovery that more than one peptide may be restricted to the same HLA antigen and function as an ...

    Authors: Monica Ghei, David F Stroncek and Maurizio Provenzano

    Citation: Journal of Translational Medicine 2005 3:23

    Content type: Research

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  38. Apo2L/TRAIL has considerable promise for cancer therapy based on the fact that this member of the tumor necrosis factor family induces apoptosis in the majority of malignant cells, while normal cells are more ...

    Authors: Bonnie L Hylander, Rose Pitoniak, Remedios B Penetrante, John F Gibbs, Dilek Oktay, Jinrong Cheng and Elizabeth A Repasky

    Citation: Journal of Translational Medicine 2005 3:22

    Content type: Research

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  39. Local myogenesis, neoangiogenesis and homing of progenitor cells from the bone marrow appear to contribute to repair of the infarcted myocardium. Implantation into heart tissues of autologous skeletal myoblast...

    Authors: Andreina Baj, Alessia A Bettaccini, Rosario Casalone, Andrea Sala, Paolo Cherubino and Antonio Q Toniolo

    Citation: Journal of Translational Medicine 2005 3:21

    Content type: Research

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  40. The assessment of cellular anti-viral immunity is often hampered by the limited availability of adequate samples, especially when attempting simultaneous, high-resolution determination of T cell responses agai...

    Authors: Florian K Bihl, Elisabetta Loggi, John V Chisholm III, Hannah S Hewitt, Leah M Henry, Caitlyn Linde, Todd J Suscovich, Johnson T Wong, Nicole Frahm, Pietro Andreone and Christian Brander

    Citation: Journal of Translational Medicine 2005 3:20

    Content type: Methodology

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  41. Immunotherapy has become a standard approach for cancer management, through the use of cytokines (eg: interleukin-2) and monoclonal antibodies. Cancer vaccines hold promise as another form of immunotherapy, an...

    Authors: Craig L Slingluff Jr and Daniel E Speiser

    Citation: Journal of Translational Medicine 2005 3:18

    Content type: Commentary

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