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  1. A sizeable number of HIV-infected patients receiving HAART do not maintain prolonged virologic suppression. We evaluated long-term HIV viral load (VL) responses to HAART as a risk factor for AIDS events (AE) t...

    Authors: Powel Kazanjian, Wei Wei, Morton Brown, Tejal Gandhi and Kamal Amin
    Citation: Journal of Translational Medicine 2005 3:40
  2. Targeted inhibition of protein kinases is now acknowledged as an effective approach for cancer therapy. However, targeted therapies probably have limited success because cancer cells have alternate pathways fo...

    Authors: Kerrington R Molhoek, David L Brautigan and Craig L Slingluff Jr
    Citation: Journal of Translational Medicine 2005 3:39
  3. The epidermal growth factor receptor (EGFR) is over expressed in approximately 50–60% of glioblastoma (GBM) tumors, and the most common EGFR mutant, EGFRvIII, is expressed in 24–67% of cases. This study was de...

    Authors: Amy B Heimberger, Dima Suki, David Yang, Weiming Shi and Kenneth Aldape
    Citation: Journal of Translational Medicine 2005 3:38
  4. IL-1β is a pleotropic cytokine that may mediate increased procoagulant activity and permeability in endothelial tissue during inflammatory conditions. The procoagulant effects of IL-1β are mediated through ind...

    Authors: Markus Puhlmann, David M Weinreich, Jeffrey M Farma, Nancy M Carroll, Ewa M Turner and H Richard Alexander Jr
    Citation: Journal of Translational Medicine 2005 3:37
  5. Myeloid-related protein 8 (MRP8) and MRP14 are S100 family calcium binding proteins that form a heterodimer known as calprotectin or MRP8/14 that is present in the cytosol of neutrophils and monocytes. MRP8/14...

    Authors: David F Stroncek, Raji A Shankar and Keith M Skubitz
    Citation: Journal of Translational Medicine 2005 3:36
  6. Ovarian cancer represents the fifth leading cause of death from all cancers for women. During the last decades overall survival has improved due to the use of new chemotherapy schedules. Still, the majority of...

    Authors: HW Nijman, A Lambeck, SH van der Burg, AGJ van der Zee and T Daemen
    Citation: Journal of Translational Medicine 2005 3:34
  7. New developments in science are rapidly influencing and shaping basic and clinical research and medicine. This has led to the emergence of multiple opportunities and challenges on many levels in the bio-medica...

    Authors: Kai-Christian Sonntag
    Citation: Journal of Translational Medicine 2005 3:33
  8. Our goal was to identify gene signatures predictive of response to preoperative systemic chemotherapy (PST) with epirubicin/cyclophosphamide (EC) in patients with primary breast cancer.

    Authors: Olga Modlich, Hans-Bernd Prisack, Marc Munnes, Werner Audretsch and Hans Bojar
    Citation: Journal of Translational Medicine 2005 3:32
  9. Over the past three decades, there have been remarkable advances in the treatment of bone and soft tissue sarcomas. These include the introduction of adjuvant chemotherapy, establishment of guidelines for adeq...

    Authors: Satoshi Kawaguchi, Takuro Wada, Tomohide Tsukahara, Kazunori Ida, Toshihiko Torigoe, Noriyuki Sato and Toshihiko Yamashita
    Citation: Journal of Translational Medicine 2005 3:31
  10. Previous studies have shown that in platelets of mild Alzheimer Disease (AD) patients there are alterations of specific APP forms, paralleled by alteration in expression level of both ADAM 10 and BACE when com...

    Authors: Monica Di Luca, Enzo Grossi, Barbara Borroni, Martina Zimmermann, Elena Marcello, Francesca Colciaghi, Fabrizio Gardoni, Marco Intraligi, Alessandro Padovani and Massimo Buscema
    Citation: Journal of Translational Medicine 2005 3:30
  11. We present a generic dendritic cell (DC) vaccine strategy for patients with renal cell carcinoma (RCC) based on the use of RNA as a source of multiplex tumor-associated antigens (TAAs). Instead of preparing RN...

    Authors: Christiane Geiger, Sybille Regn, Andreas Weinzierl, Elfriede Noessner and Dolores J Schendel
    Citation: Journal of Translational Medicine 2005 3:29
  12. The study of clinical samples is often limited by the amount of material available to study. While proteins cannot be multiplied in their natural form, DNA and RNA can be amplified from small specimens and use...

    Authors: Ena Wang
    Citation: Journal of Translational Medicine 2005 3:28
  13. The purpose of the present investigation was to determine if the salivary counts of 40 common oral bacteria in subjects with an oral squamous cell carcinoma (OSCC) lesion would differ from those found in cance...

    Authors: DL Mager, AD Haffajee, PM Devlin, CM Norris, MR Posner and JM Goodson
    Citation: Journal of Translational Medicine 2005 3:27
  14. Nasopharyngeal carcinoma (NPC) is a tumor derived from epithelial cells and Epstein-Barr virus infection has been reported to be a cause of this disease. Chemokine receptor CXCR4 was found to be involved in HI...

    Authors: Na Wang, Qiu-Liang Wu, Yan Fang, Hai-Qiang Mai, Mu-Sheng Zeng, Guo-Ping Shen, Jing-Hui Hou and Yi-Xin Zeng
    Citation: Journal of Translational Medicine 2005 3:26
  15. Epithelial ovarian cancer (EOC) represents the most frequent cause of death in the United States from a cancer involving the female genital tract. Contributing to the overall poor outcome in EOC patients, are ...

    Authors: Xipeng Wang, Ena Wang, John J Kavanagh and Ralph S Freedman
    Citation: Journal of Translational Medicine 2005 3:25
  16. Interferon (IFN)-α is considered a key modulator of immunopathological processes through a signature-specific activation of mononuclear phagocytes (MPs). This study utilized global transcript analysis to chara...

    Authors: David F Stroncek, Christopher Basil, Dirk Nagorsen, Sara Deola, Eleonora Aricó, Kina Smith, Ena Wang, Francesco M Marincola and Monica C Panelli
    Citation: Journal of Translational Medicine 2005 3:24
  17. The continuous efforts aimed at the identification of new immune epitopes across the MHC system has led to the discovery that more than one peptide may be restricted to the same HLA antigen and function as an ...

    Authors: Monica Ghei, David F Stroncek and Maurizio Provenzano
    Citation: Journal of Translational Medicine 2005 3:23
  18. Apo2L/TRAIL has considerable promise for cancer therapy based on the fact that this member of the tumor necrosis factor family induces apoptosis in the majority of malignant cells, while normal cells are more ...

    Authors: Bonnie L Hylander, Rose Pitoniak, Remedios B Penetrante, John F Gibbs, Dilek Oktay, Jinrong Cheng and Elizabeth A Repasky
    Citation: Journal of Translational Medicine 2005 3:22
  19. Local myogenesis, neoangiogenesis and homing of progenitor cells from the bone marrow appear to contribute to repair of the infarcted myocardium. Implantation into heart tissues of autologous skeletal myoblast...

    Authors: Andreina Baj, Alessia A Bettaccini, Rosario Casalone, Andrea Sala, Paolo Cherubino and Antonio Q Toniolo
    Citation: Journal of Translational Medicine 2005 3:21
  20. The assessment of cellular anti-viral immunity is often hampered by the limited availability of adequate samples, especially when attempting simultaneous, high-resolution determination of T cell responses agai...

    Authors: Florian K Bihl, Elisabetta Loggi, John V Chisholm III, Hannah S Hewitt, Leah M Henry, Caitlyn Linde, Todd J Suscovich, Johnson T Wong, Nicole Frahm, Pietro Andreone and Christian Brander
    Citation: Journal of Translational Medicine 2005 3:20
  21. Immunotherapy has become a standard approach for cancer management, through the use of cytokines (eg: interleukin-2) and monoclonal antibodies. Cancer vaccines hold promise as another form of immunotherapy, an...

    Authors: Craig L Slingluff Jr and Daniel E Speiser
    Citation: Journal of Translational Medicine 2005 3:18
  22. In vitro stimulation of CD34+ cells with IL-2 induces NK cell differentiation. In order to define the stages of NK cell development, which influence their generation from CD34 cells, we cultured G-CSF mobilize...

    Authors: Giuseppe Sconocchia, Maurizio Provenzano, Katayoun Rezvani, Jongming Li, Jos Melenhorst, Nancy Hensel and A John Barrett
    Citation: Journal of Translational Medicine 2005 3:15
  23. Although several genes and proteins have been implicated in the development of melanomas, the molecular mechanisms involved in the development of these tumors are not well understood. To gain a better understa...

    Authors: Suraiya Rasheed, Zisu Mao, Jane MC Chan and Linda S Chan
    Citation: Journal of Translational Medicine 2005 3:14
  24. The aim of this study was to determine the basis for anti-tumor immune reactivity observed in patients with human epidermal growth factor receptor-2 (HER-2) (3+) breast carcinoma using an in vitro model in which ...

    Authors: Zorica D Juranic, Zora Neskovic-Konstantinovic, Tatjana P Stanojkovic, Zeljko Zizak, Tatjana Srdic, Nevenka Stanojevic-Bakic, Dusanka Milosevic and Danica Jovanovic
    Citation: Journal of Translational Medicine 2005 3:13
  25. Sixty cancer cell lines have been extensively characterized and used by the National Cancer Institute's Developmental Therapeutics Program (NCI-60) since the early 90's as screening tools for anti-cancer drug ...

    Authors: Sharon Adams, Fu-Meei Robbins, Deborah Chen, Devika Wagage, Susan L Holbeck, Herbert C Morse III, David Stroncek and Francesco M Marincola
    Citation: Journal of Translational Medicine 2005 3:11
  26. DC derived-exosomes are nanomeric vesicles harboring functional MHC/peptide complexes capable of promoting T cell immune responses and tumor rejection. Here we report the feasability and safety of the first Ph...

    Authors: Bernard Escudier, Thierry Dorval, Nathalie Chaput, Fabrice André, Marie-Pierre Caby, Sophie Novault, Caroline Flament, Christophe Leboulaire, Christophe Borg, Sebastian Amigorena, Catherine Boccaccio, Christian Bonnerot, Olivier Dhellin, Mojgan Movassagh, Sophie Piperno, Caroline Robert…
    Citation: Journal of Translational Medicine 2005 3:10
  27. There is a continued need to develop more effective cancer immunotherapy strategies. Exosomes, cell-derived lipid vesicles that express high levels of a narrow spectrum of cell proteins represent a novel platf...

    Authors: Michael A Morse, Jennifer Garst, Takuya Osada, Shubi Khan, Amy Hobeika, Timothy M Clay, Nancy Valente, Revati Shreeniwas, Mary Ann Sutton, Alain Delcayre, Di-Hwei Hsu, Jean-Bernard Le Pecq and H Kim Lyerly
    Citation: Journal of Translational Medicine 2005 3:9
  28. Nitric oxide-releasing nonsteroidal antiinflammatory drugs (NO-NSAIDs) are reported to be safer than NSAIDs because of their lower gastric toxicity. We compared the effect of a novel NO-releasing derivate, NCX...

    Authors: Anna Tesei, Paola Ulivi, Francesco Fabbri, Marco Rosetti, Carlo Leonetti, Marco Scarsella, Gabriella Zupi, Dino Amadori, Manlio Bolla and Wainer Zoli
    Citation: Journal of Translational Medicine 2005 3:7
  29. Serologic tests for HIV infection in infants less than 18 months do not differentiate exposure and infection since maternally acquired IgG antibodies may be detected in infants. Thus, the gold standard for dia...

    Authors: Lynn S Zijenah, David A Katzenstein, Kusum J Nathoo, Simbarashe Rusakaniko, Ocean Tobaiwa, Christine Gwanzura, Arsene Bikoue, Margaret Nhembe, Petronella Matibe and George Janossy
    Citation: Journal of Translational Medicine 2005 3:6
  30. CD4+CD25+ regulatory T lymphocytes (TR) constitute 5–10% of peripheral CD4+ T cells in naive mice and humans, and play an important role in controlling immune responses. Accumulating evidences show that TR cells ...

    Authors: Ji-Yan Liu, Xiao-Shi Zhang, Ya Ding, Rui-Qing Peng, Xia Cheng, Nian-Hua Zhang, Jian-Chuan Xia and Yi-Xin Zeng
    Citation: Journal of Translational Medicine 2005 3:5
  31. Metastatic, chemotherapy-resistant melanoma is an intractable cancer with a very poor prognosis. As to immunotherapy targeting metastatic melanoma, HLA-A2+ patients were mainly enrolled in the study in Western co...

    Authors: Yasuto Akiyama, Ryuji Tanosaki, Naoki Inoue, Makiko Shimada, Yukie Hotate, Akifumi Yamamoto, Naoya Yamazaki, Ichiro Kawashima, Ikuei Nukaya, Kazutoh Takesako, Kouji Maruyama, Yoichi Takaue and Ken Yamaguchi
    Citation: Journal of Translational Medicine 2005 3:4
  32. Spontaneous T cell responses against specific tumor-associated antigens (TAA) are frequently detected in peripheral blood of tumor patients of various histiotypes. However, little is known about whether these ...

    Authors: Dirk Nagorsen, Carmen Scheibenbogen, Anne Letsch, Christoph-Thomas Germer, Heinz-Johannes Buhr, Susanna Hegewisch-Becker, Licia Rivoltini, Eckhard Thiel and Ulrich Keilholz
    Citation: Journal of Translational Medicine 2005 3:3
  33. Synovial sarcoma is a high-grade malignant tumor of soft tissue, characterized by the specific chromosomal translocation t(X;18), and its resultant SYT-SSX fusion gene. Despite intensive multimodality therapy,...

    Authors: Satoshi Kawaguchi, Takuro Wada, Kazunori Ida, Yuriko Sato, Satoshi Nagoya, Tomohide Tsukahara, Sigeharu Kimura, Hiroeki Sahara, Hideyuki Ikeda, Kumiko Shimozawa, Hiroko Asanuma, Toshihiko Torigoe, Hiroaki Hiraga, Takeshi Ishii, Shin-ichiro Tatezaki, Noriyuki Sato…
    Citation: Journal of Translational Medicine 2005 3:1
  34. Forty to eighty percent of melanoma tumors have activating mutations in BRAF although the clinical importance of these mutations is not clear. We previously reported an analysis of BRAF mutations in metastatic me...

    Authors: David Z Chang, Katherine S Panageas, Iman Osman, David Polsky, Klaus Busam and Paul B Chapman
    Citation: Journal of Translational Medicine 2004 2:46
  35. Immunosuppression is documented in several malignant diseases, including breast cancer. Subsequently, future therapeutic concepts might include immunological approaches. However, detailed knowledge about tumor...

    Authors: Jana M Schüle, Leif Bergkvist, Leif Håkansson, Bertil Gustafsson and Annika Håkansson
    Citation: Journal of Translational Medicine 2004 2:45
  36. Walking along disease-associated protein sequences in the search for specific segments able to induce cellular immune response may direct clinical research towards effective peptide-based vaccines. To this aim...

    Authors: Alberta Lucchese, Abraham Mittelman, Mong-Shang Lin, Darja Kanduc and Animesh A Sinha
    Citation: Journal of Translational Medicine 2004 2:43
  37. Tumors and viruses have developed many mechanisms to evade the immune system, including down-regulation of target antigens and MHC molecules. These immune escape mechanisms may be able to be circumvented by ad...

    Authors: Alexander Langerman, Glenda G Callender and Michael I Nishimura
    Citation: Journal of Translational Medicine 2004 2:42
  38. T cell-mediated cancer immunotherapy is dose dependent and optimally requires participation of antigen-specific CD4+ and CD8+ T cells. Here, we isolated tumor-sensitized T cells and activated them in vitro using ...

    Authors: Li-Xin Wang, Wen-Xin Huang, Hallie Graor, Peter A Cohen, Julian A Kim, Suyu Shu and Gregory E Plautz
    Citation: Journal of Translational Medicine 2004 2:41
  39. A novel tyrosine kinase receptor EphA2 is expressed at high levels in advanced and metastatic cancers. We examined whether vaccinations with synthetic mouse EphA2 (mEphA2)-derived peptides that serve as T cell...

    Authors: Manabu Hatano, Naruo Kuwashima, Tomohide Tatsumi, Jill E Dusak, Fumihiko Nishimura, Karlyne M Reilly, Walter J Storkus and Hideho Okada
    Citation: Journal of Translational Medicine 2004 2:40
  40. Over the past decade RNA interference (RNAi) has emerged as a natural mechanism for silencing gene expression. This ancient cellular antiviral response can be exploited to allow specific inhibition of the func...

    Authors: Simone Mocellin and Maurizio Provenzano
    Citation: Journal of Translational Medicine 2004 2:39
  41. D-dimer is considered a marker of hypercoagulable state and of endogenous fibrinolysis, so increased d-dimer is detectable in patients affected by thrombosis. Yet, several studies showed that also infertility,...

    Authors: Pierpaolo Di Micco, Maristella D'Uva, Ida Strina, Antonio Mollo, Valeria Amato, Alferio Niglio and Giuseppe De Placido
    Citation: Journal of Translational Medicine 2004 2:38

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