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Page 94 of 109

  1. The aim of this proteomic study was to look for changes taking place in plasma proteomes of patients with acute myocardial infarction (AMI), unstable angina pectoris (UAP), and stable angina pectoris (SAP).

    Authors: Pavel Májek, Zuzana Reicheltová, Jiří Suttnar, Martin Malý, Milan Oravec, Klára Pečánková and Jan E Dyr
    Citation: Journal of Translational Medicine 2011 9:84
  2. Preliminary experimental studies have suggested that the in situ destruction of tumor tissue by local laser ablation (LA) may also stimulate host immunity against cancer. We investigated local and systemic ind...

    Authors: Wen Xu Lin, Theodora Fifis, Caterina Malcontenti-Wilson, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Linh Nguyen and Christopher Christophi
    Citation: Journal of Translational Medicine 2011 9:83
  3. Colorectal cancer (CRC) is the predominant gastrointestinal malignancy and the leading cause of cancer death. The identification of genes related to CRC is important for the development of successful therapies...

    Authors: Chi-Jung Huang, Shung-Haur Yang, Shih-Ming Huang, Chih-Ming Lin, Chih-Cheng Chien, Yan-Chu Chen, Chia-Long Lee, Hao-Han Wu and Chun-Chao Chang
    Citation: Journal of Translational Medicine 2011 9:82
  4. Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is characterised by severe prolonged fatigue, and decreases in cognition and other physiological functions, resulting in severe loss of quality of li...

    Authors: Ekua W Brenu, Mieke L van Driel, Don R Staines, Kevin J Ashton, Sandra B Ramos, James Keane, Nancy G Klimas and Sonya M Marshall-Gradisnik
    Citation: Journal of Translational Medicine 2011 9:81
  5. Variability of plasma sample collection and of proteomics technology platforms has been detrimental to generation of large proteomic profile datasets from human biospecimens.

    Authors: Catherine P Riley, Xiang Zhang, Harikrishna Nakshatri, Bryan Schneider, Fred E Regnier, Jiri Adamec and Charles Buck
    Citation: Journal of Translational Medicine 2011 9:80
  6. Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, se...

    Authors: Thomas GP Grunewald, Saskia M Herbst, Jürgen Heinze and Stefan Burdach
    Citation: Journal of Translational Medicine 2011 9:79
  7. The prognosis of cutaneous melanoma (CM) differs for patients with identical clinico-pathological stage, and no molecular markers discriminating the prognosis of stage III individuals have been established. Ge...

    Authors: Luca Sigalotti, Elisabetta Fratta, Ettore Bidoli, Alessia Covre, Giulia Parisi, Francesca Colizzi, Sandra Coral, Samuele Massarut, John M Kirkwood and Michele Maio
    Citation: Journal of Translational Medicine 2011 9:78
  8. Time-dependent chemotherapeutic agents can selectively target tumor cells in susceptible phases of the cell cycle however a fraction of tumor cells in non-vulnerable cell cycle phases remain drug-resistant. Im...

    Authors: Ioannis Alagkiozidis, Andrea Facciabene, Marinos Tsiatas, Carmine Carpenito, Fabian Benencia, Sarah Adams, Zdenka Jonak, Carl H June, Daniel J Powell Jr and George Coukos
    Citation: Journal of Translational Medicine 2011 9:77
  9. A molecular linkage between the MAPK and the LKB1-AMPK energy sensor pathways suggests that combined MAPK oncogene inhibition and metabolic modulation of AMPK would be more effective than either manipulation a...

    Authors: Franziska Niehr, Erika von Euw, Narsis Attar, Deliang Guo, Doug Matsunaga, Hooman Sazegar, Charles Ng, John A Glaspy, Juan A Recio, Roger S Lo, Paul S Mischel, Begonya Comin-Anduix and Antoni Ribas
    Citation: Journal of Translational Medicine 2011 9:76
  10. Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Most GIST harbor a mutation affecting either the KIT or PDGFRA genes, whereas a small subgroup of tu...

    Authors: Alessandra Maleddu, Maria A Pantaleo, Margherita Nannini and Guido Biasco
    Citation: Journal of Translational Medicine 2011 9:75
  11. Aurora kinase ensures accurate chromosome segregation during cell cycle, maintaining genetic integrity in cell division. VX-680, a small-molecule Aurora kinase inhibitor, interferes with mitotic entry and form...

    Authors: Duo-Rong Xu, Shan Huang, Zi-Jie Long, Jia-Jie Chen, Zheng-Zhi Zou, Juan Li, Dong-Jun Lin and Quentin Liu
    Citation: Journal of Translational Medicine 2011 9:74
  12. Our previous studies indicate that either PEP-1-superoxide dismutase 1 (SOD1) or PEP-1-catalase (CAT) fusion proteins protects myocardium from ischemia-reperfusion-induced injury in rats. The aim of this study...

    Authors: Guang-Qing Huang, Jia-Ning Wang, Jun-Ming Tang, Lei Zhang, Fei Zheng, Jian-Ye Yang, Ling-Yun Guo, Xia Kong, Yong-Zhang Huang, Yong Liu and Shi-You Chen
    Citation: Journal of Translational Medicine 2011 9:73
  13. The sulfation pattern of heparan sulfate chains influences signaling events mediated by heparan sulfate proteoglycans located on cell surface. SULF1 and SULF2 are two endosulfatases able to cleave specific 6-O...

    Authors: Caroline Bret, Jérôme Moreaux, Jean-François Schved, Dirk Hose and Bernard Klein
    Citation: Journal of Translational Medicine 2011 9:72
  14. Acute myeloid leukemia (AML) is an immunophenotypically heterogenous malignant disease, in which CD34 positivity is associated with poor prognosis. CD34+ AML cells are 10-15-fold more resistant to daunorubicin (D...

    Authors: Jia Rao, Duo-Rong Xu, Fei-Meng Zheng, Zi-Jie Long, Sheng-Shan Huang, Xing Wu, Wei-Hua Zhou, Ren-Wei Huang and Quentin Liu
    Citation: Journal of Translational Medicine 2011 9:71
  15. A limitation of positive selection strategies to enrich for circulating tumor cells (CTCs) is that there might be CTCs with insufficient expression of the surface target marker which may be missed by the proce...

    Authors: Zhian Liu, Alberto Fusi, Eva Klopocki, Alexander Schmittel, Ingeborg Tinhofer, Anika Nonnenmacher and Ulrich Keilholz
    Citation: Journal of Translational Medicine 2011 9:70
  16. The HPV16 E7 protein is both a tumour-specific and a tumour-rejection antigen, the ideal target for developing therapeutic vaccines for the treatment of HPV16-associated cancer and its precursor lesions. E7, w...

    Authors: Linda Petrone, Maria G Ammendolia, Armando Cesolini, Stefano Caimi, Fabiana Superti, Colomba Giorgi and Paola Di Bonito
    Citation: Journal of Translational Medicine 2011 9:69
  17. Duchenne muscular dystrophy (DMD) is an inherited and progressive disease causing striated muscle deterioration. Patients in their twenties generally die from either respiratory or cardiac failure. In order to...

    Authors: Dawn A Delfín, Ying Xu, Jennifer M Peterson, Denis C Guttridge, Jill A Rafael-Fortney and Paul ML Janssen
    Citation: Journal of Translational Medicine 2011 9:68
  18. Interferons alpha (IFNα) are the cytokines most widely used in clinical medicine for the treatment of cancer and viral infections. Among the immunomodulatory activities possibly involved in their therapeutic e...

    Authors: Eleonora Aricò, Luciano Castiello, Francesca Urbani, Paola Rizza, Monica C Panelli, Ena Wang, Francesco M Marincola and Filippo Belardelli
    Citation: Journal of Translational Medicine 2011 9:67
  19. The differential diagnosis for hereditary ataxia encompasses a variety of diseases characterized by both autosomal dominant and recessive inheritance. There are no curative treatments available for these neuro...

    Authors: Wan-Zhang Yang, Yun Zhang, Fang Wu, Min Zhang, SC Cho, Chun-Zhen Li, Shao-Hui Li, Guo-Jian Shu, You-Xiang Sheng, Ning Zhao, Ying Tang, Shu Jiang, Shan Jiang, Matthew Gandjian, Thomas E Ichim and Xiang Hu
    Citation: Journal of Translational Medicine 2011 9:65
  20. c-Met is a receptor tyrosine kinase (RTK) that is over-expressed in a variety of cancers and involved in cell growth, invasion, metastasis and angiogenesis. In this study, we investigated the role of c-Met in ...

    Authors: Jinxuan Hou, Jixin Dong, Lijun Sun, Liying Geng, Jing Wang, Jialin Zheng, Yan Li, Julia Bridge, Steven H Hinrichs and Shi-Jian Ding
    Citation: Journal of Translational Medicine 2011 9:64
  21. Adoptive cell therapy (ACT) has emerged as an effective treatment for patients with metastatic melanoma. However, there are several logistical and safety concerns associated with large-scale ex vivo expansion of ...

    Authors: Thomas Zuliani, Julien David, Sylvain Bercegeay, Marie-Christine Pandolfino, Isabelle Rodde-Astier, Amir Khammari, Cécile Coissac, Bruno Delorme, Soraya Saïagh and Brigitte Dréno
    Citation: Journal of Translational Medicine 2011 9:63
  22. Berberine (BBR) is a drug with multiple effects on cellular energy metabolism. The present study explored answers to the question of which CYP450 (Cytochrome P450) isoenzymes execute the phase-I transformation...

    Authors: Yi Li, Gang Ren, Yan-Xiang Wang, Wei-Jia Kong, Peng Yang, Yue-Ming Wang, Ying-Hong Li, Hong Yi, Zhuo-Rong Li, Dan-Qing Song and Jian-Dong Jiang
    Citation: Journal of Translational Medicine 2011 9:62
  23. Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is an early characteristic of multiple organ dysfunction, responsible for high mortality and poor prognosis in patients. The present study...

    Authors: Meitang Wang, Tao Liu, Dian Wang, Yonghua Zheng, Xiangdong Wang and Jian He
    Citation: Journal of Translational Medicine 2011 9:61
  24. Led by key opinion leaders in the field, the 25th Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC) provided a...

    Authors: James M Balwit, Pawel Kalinski, Vernon K Sondak, Pierre G Coulie, Elizabeth M Jaffee, Thomas F Gajewski and Francesco M Marincola
    Citation: Journal of Translational Medicine 2011 9:60
  25. Implantation and growth of metastatic cancer cells at distant organs is promoted by inflammation-dependent mechanisms. A hepatic melanoma metastasis model where a majority of metastases are generated via inter...

    Authors: Clarisa Salado, Elvira Olaso, Natalia Gallot, Maria Valcarcel, Eider Egilegor, Lorea Mendoza and Fernando Vidal-Vanaclocha
    Citation: Journal of Translational Medicine 2011 9:59
  26. Neuroserpin has shown neuroprotective effects in animal models of cerebral ischemia and has been associated with functional outcome after ischemic stroke. Our aim was to study whether neuroserpin serum levels ...

    Authors: Raquel Rodríguez-González, Tomás Sobrino, Manuel Rodríguez-Yáñez, Mónica Millán, David Brea, Elena Miranda, Octavio Moldes, Juan Pérez, David A Lomas, Rogelio Leira, Antoni Dávalos and José Castillo
    Citation: Journal of Translational Medicine 2011 9:58
  27. Pharmaceutical industry consolidation and overall research downsizing threatens the ability of companies to benefit from their previous investments in translational research as key leaders with the most knowle...

    Authors: Bruce H Littman and Francesco M Marincola
    Citation: Journal of Translational Medicine 2011 9:56
  28. Hepatocyte growth factor (HGF) stimulates hepatocyte proliferation, and also acts as an anti-apoptotic factor. Therefore, HGF is a potential therapeutic agent for treatment of fatal liver diseases. We performe...

    Authors: Akio Ido, Akihiro Moriuchi, Masatsugu Numata, Toshinori Murayama, Satoshi Teramukai, Hiroyuki Marusawa, Naohisa Yamaji, Hitoshi Setoyama, Il-Deok Kim, Tsutomu Chiba, Shuji Higuchi, Masayuki Yokode, Masanori Fukushima, Akira Shimizu and Hirohito Tsubouchi
    Citation: Journal of Translational Medicine 2011 9:55
  29. In 2009 the NIH publicly announced five strategic goals for the institutes that included the critical need to translate research discoveries into public benefit at an accelerated pace, with a commitment to fin...

    Authors: Michael R Emmert-Buck
    Citation: Journal of Translational Medicine 2011 9:54
  30. Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has been considered as a promising treatment modality for gastric cancer with peritoneal carcinomatosis (PC). However, there h...

    Authors: Li Tang, Lie-Jun Mei, Xiao-Jun Yang, Chao-Qun Huang, Yun-Feng Zhou, Yutaka Yonemura and Yan Li
    Citation: Journal of Translational Medicine 2011 9:53
  31. High-dose Interferon (HDI) therapy produces a clinical response and achieves relapse-free survival in 20-33% of patients with operable high risk or metastatic melanoma. However, patients may develop significan...

    Authors: Diana L Simons, Gerald Lee, John M Kirkwood and Peter P Lee
    Citation: Journal of Translational Medicine 2011 9:52
  32. Reactive oxygen species are important mediators exerting toxic effects on various organs during ischemia-reperfusion (IR) injury. We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) protect th...

    Authors: Yen-Ta Chen, Cheuk-Kwan Sun, Yu-Chun Lin, Li-Teh Chang, Yung-Lung Chen, Tzu-Hsien Tsai, Sheng-Ying Chung, Sarah Chua, Ying-Hsien Kao, Chia-Hung Yen, Pei-Lin Shao, Kuan-Cheng Chang, Steve Leu and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2011 9:51
  33. Emerging evidence suggests that cancer stem cells account for the initiation and progression of cancer. While many types of cancer stem cells with specific markers have been isolated and identified, a variety ...

    Authors: Hai-Guang Liu, Chong Chen, Han Yang, Yi-Fei Pan and Xiao-Hua Zhang
    Citation: Journal of Translational Medicine 2011 9:50
  34. Transglutamiase-4 (TGase-4), also known as prostate transglutaminase, belongs to the TGase family and is uniquely expressed in the prostate gland. The functions of this interesting protein are not clearly defi...

    Authors: Richard J Ablin, Howard G Kynaston, Malcolm D Mason and Wen G Jiang
    Citation: Journal of Translational Medicine 2011 9:49
  35. siRNA technology is a promising tool for gene therapy of vascular disease. Due to the multitude of reagents and cell types, RNAi experiment optimization can be time-consuming. In this study adherent cell cytom...

    Authors: Christoph S Nabzdyk, Maggie Chun, Leena Pradhan and Frank W LoGerfo
    Citation: Journal of Translational Medicine 2011 9:48
  36. Exosomes or secreted bi-lipid vesicles from human ESC-derived mesenchymal stem cells (hESC-MSCs) have been shown to reduce myocardial ischemia/reperfusion injury in animal models. However, as hESC-MSCs are not...

    Authors: Tian Sheng Chen, Fatih Arslan, Yijun Yin, Soon Sim Tan, Ruenn Chai Lai, Andre Boon Hwa Choo, Jayanthi Padmanabhan, Chuen Neng Lee, Dominique PV de Kleijn and Sai Kiang Lim
    Citation: Journal of Translational Medicine 2011 9:47
  37. Polyethyleneimine (PEI), which can interact with negatively charged DNA through electrostatic interaction to form nanocomplexes, has been widely attempted to use as a gene delivery system. However, PEI has som...

    Authors: Zhizhong Xu, Guobo Shen, Xiangying Xia, Xinyu Zhao, Peng Zhang, Huanhuan Wu, Qingfa Guo, Zhiyong Qian, Yuquan Wei and Shufang Liang
    Citation: Journal of Translational Medicine 2011 9:46
  38. We previously demonstrated that the plant-derived agent α-bisabolol enters cells via lipid rafts, binds to the pro-apoptotic Bcl-2 family protein BID, and may induce apoptosis. Here we studied the activity of α-b...

    Authors: Elisabetta Cavalieri, Antonella Rigo, Massimiliano Bonifacio, Alessandra Carcereri de Prati, Emanuele Guardalben, Christian Bergamini, Romana Fato, Giovanni Pizzolo, Hisanori Suzuki and Fabrizio Vinante
    Citation: Journal of Translational Medicine 2011 9:45
  39. The differentiation of CD8+ T lymphocytes following priming of naïve cells is central in the establishment of the adaptive immune response. Yet, the molecular events underlying this process are not fully understo...

    Authors: Bruno Salaun, Takuya Yamamoto, Bassam Badran, Yasuko Tsunetsugu-Yokota, Antoine Roux, Lukas Baitsch, Redouane Rouas, Hussein Fayyad-Kazan, Petra Baumgaertner, Estelle Devevre, Anirudh Ramesh, Marion Braun, Daniel Speiser, Brigitte Autran, Philippe Martiat, Victor Appay…
    Citation: Journal of Translational Medicine 2011 9:44
  40. The lack of sufficient specificity and sensitivity among conventional cancer biomarkers, such as prostate specific antigen (PSA) for prostate cancer has been widely recognized after several decades of clinical...

    Authors: Chong Xie, Hyun J Kim, Jonathan G Haw, Anusha Kalbasi, Brian K Gardner, Gang Li, Jianyu Rao, David Chia, Monty Liong, Rubio R Punzalan, Leonard S Marks, Allan J Pantuck, Alexandre de la Taille, Guomin Wang, Hideki Mukouyama and Gang Zeng
    Citation: Journal of Translational Medicine 2011 9:43
  41. Increased synthesis of neopterin and degradation of tryptophan to kynurenine, measured as kynurenine/tryptophan ratio (kyn/trp ratio), are considered in vitro markers of interferon beta-1a (IFNβ-1a) activity. The...

    Authors: Valentina Durastanti, Alessandra Lugaresi, Placido Bramanti, Mariapia Amato, Paolo Bellantonio, Giovanna De Luca, Orietta Picconi, Roberta Fantozzi, Laura Locatelli, Annalisa Solda', Edoardo Sessa, Rocco Totaro, Silvia Marino, Valentina Zipoli, Marino Zorzon and Enrico Millefiorini
    Citation: Journal of Translational Medicine 2011 9:42
  42. Granulysin is an antimicrobial and proinflammatory protein with several isoforms. While the 9 kDa isoform is a well described cytolytic molecule with pro-inflammatory activity, the functions of the 15 kDa isof...

    Authors: Luciano Castiello, David F Stroncek, Michael W Finn, Ena Wang, Francesco M Marincola, Carol Clayberger, Alan M Krensky and Marianna Sabatino
    Citation: Journal of Translational Medicine 2011 9:41
  43. Novel, exciting intervention strategies to prevent infection with HIV have been tested in the past year, and the field is rapidly evolving. EUROPRISE is a network of excellence sponsored by the European Commis...

    Authors: Sarah Brinckmann, Kelly da Costa, Marit J van Gils, David Hallengärd, Katja Klein, Luisa Madeira, Lara Mainetti, Paolo Palma, Katharina Raue, David Reinhart, Marc Reudelsterz, Nicolas Ruffin, Janna Seifried, Katrein Schäfer, Enas Sheik-Khalil, Annette Sköld…
    Citation: Journal of Translational Medicine 2011 9:40
  44. Gene therapy is a promising therapeutic approach for cancer. Targeted expression of desired therapeutic proteins within the tumor is the best approach to reduce toxicity and improve survival. This study is to ...

    Authors: Yu Xu, Jinxuan Hou, Zhengchun Liu, Haijun Yu, Wenjie Sun, Jie Xiong, Zhengkai Liao, Fuxiang Zhou, Conghua Xie and Yunfeng Zhou
    Citation: Journal of Translational Medicine 2011 9:39
  45. The aim of the present study was to analyze the expression of Cyclin-dependent kinase 4 (CDK4) in lung cancer and its correlation with clinicopathologic features. Furthermore, the involvement of CDK4-mediated cel...

    Authors: Aibing Wu, Bin Wu, Jinsong Guo, Weiren Luo, Dong Wu, Huiling Yang, Yan Zhen, Xiaoli Yu, Hao Wang, Ying Zhou, Zhen Liu, Weiyi Fang and Zhixiong Yang
    Citation: Journal of Translational Medicine 2011 9:38
  46. Interleukin-13 Receptor α2 (IL-13Rα2) is a tumor-associated antigen and target for cancer therapy. Since IL-13Rα2 is heterogeneously overexpressed in a variety of human cancers, it would be highly desirable to...

    Authors: Toshio Fujisawa, Bharat H Joshi and Raj K Puri
    Citation: Journal of Translational Medicine 2011 9:37
  47. Emerging data from pre-clinical and clinical studies suggest that HER-2/neu-specific T cell responses could induce HER-2/neu antigen loss in the tumor cells. These data suggest that patients with HER-2/neu neg...

    Authors: Maciej Kmieciak, Kyle K Payne, Michael O Idowu, Margaret M Grimes, Laura Graham, Maria-Libera Ascierto, Ena Wang, Xiang-Yang Wang, Harry D Bear and Masoud H Manjili
    Citation: Journal of Translational Medicine 2011 9:35
  48. Many peptide-based cancer vaccines have been tested in clinical trials with a limited success, mostly due to difficulties associated with peptide stability and delivery, resulting in inefficient antigen presen...

    Authors: Wenxue Ma, Trevor Smith, Vladimir Bogin, Yu Zhang, Cengiz Ozkan, Mihri Ozkan, Melanie Hayden, Stephanie Schroter, Ewa Carrier, Davorka Messmer, Vipin Kumar and Boris Minev
    Citation: Journal of Translational Medicine 2011 9:34

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